#=GF ID Mga
#=GF AC PF05043.19
#=GF DE Mga helix-turn-helix domain
#=GF AU Moxon SJ;0000-0003-4644-1816
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Pfam-B_5126 (release 7.7)
#=GF GA 21.10 21.10;
#=GF TC 21.10 21.10;
#=GF NC 21.00 21.00;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 81514348 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF WK Mga_(protein)
#=GF CL CL0123
#=GF RN [1]
#=GF RM 11952907
#=GF RT Two DNA-binding domains of Mga are required for virulence gene
#=GF RT activation in the group A streptococcus.
#=GF RA McIver KS, Myles RL;
#=GF RL Mol Microbiol 2002;43:1591-1601.
#=GF RN [2]
#=GF RM 11988525
#=GF RT Group A streptococcal RofA-type global regulators exhibit a
#=GF RT strain-specific genomic presence and regulation pattern.
#=GF RA Kreikemeyer B, Beckert S, Braun-Kiewnick A, Podbielski A;
#=GF RL Microbiology 2002;148:1501-1511.
#=GF DR INTERPRO; IPR007737;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC M regulator protein trans-acting positive regulator (Mga) is a
#=GF CC DNA-binding protein that activates the expression of several
#=GF CC important virulence genes in group A streptococcus in response
#=GF CC to changing environmental conditions [1]. This domain is found
#=GF CC in the centre of the Mga proteins. This family also contains a
#=GF CC number of bacterial RofA transcriptional regulators that seem to
#=GF CC be largely restricted to streptococci. These proteins have been
#=GF CC shown to regulate the expression of important bacterial adhesins
#=GF CC [2]. This is presumably a DNA-binding domain.
#=GF SQ 3171
#=GS A0A1B7JXU6_9GAMM/78-167 AC A0A1B7JXU6.1
#=GS A0A0R2C8G9_9LACO/86-165 AC A0A0R2C8G9.1
#=GS A0A099W3I0_9LIST/74-160 AC A0A099W3I0.1
#=GS A0A317KU58_9BACI/83-166 AC A0A317KU58.1
#=GS A0A2N5G9B4_9BACI/81-170 AC A0A2N5G9B4.1
#=GS A0A224XC65_9LACT/79-167 AC A0A224XC65.1
#=GS Q03T91_LEVBA/72-158 AC Q03T91.1
#=GS A0A949K780_9FIRM/83-167 AC A0A949K780.1
#=GS D4GNN8_PANAM/148-225 AC D4GNN8.1
#=GS F3YAN2_MELPT/52-139 AC F3YAN2.1
#=GS R3WP72_9ENTE/73-159 AC R3WP72.1
#=GS U2N1V4_9CLOT/77-163 AC U2N1V4.1
#=GS W0HNL0_9GAMM/86-171 AC W0HNL0.1
#=GS A0A0U3FFV2_EUBLI/74-157 AC A0A0U3FFV2.1
#=GS R5GAI6_9FIRM/78-167 AC R5GAI6.1
#=GS K8E5Z5_CARML/80-165 AC K8E5Z5.2
#=GS A0A0D6A3C9_9LACO/74-163 AC A0A0D6A3C9.1
#=GS A0A0R2L672_9LACO/83-153 AC A0A0R2L672.1
#=GS A0A919S1N3_9CLOT/73-161 AC A0A919S1N3.1
#=GS C9A999_ENTCA/81-162 AC C9A999.2
#=GS A0A242K0N7_9ENTE/77-161 AC A0A242K0N7.1
#=GS A0A391PEY7_9FIRM/82-171 AC A0A391PEY7.1
#=GS R2STC8_9ENTE/86-161 AC R2STC8.1
#=GS A0A0R2CJN4_9LACO/82-164 AC A0A0R2CJN4.1
#=GS A0A0F4LWN1_9LACO/64-145 AC A0A0F4LWN1.1
#=GS U6Q2E4_9CLOT/74-155 AC U6Q2E4.1
#=GS A0A077PJM1_XENBV/83-172 AC A0A077PJM1.1
#=GS S1N8U3_9ENTE/73-159 AC S1N8U3.1
#=GS U2NJM4_9CLOT/82-168 AC U2NJM4.1
#=GS A0A978C5D0_9BACI/93-171 AC A0A978C5D0.1
#=GS A0A429Z821_9ENTE/90-177 AC A0A429Z821.1
#=GS A0A1I2K8I1_9CLOT/78-162 AC A0A1I2K8I1.1
#=GS A0A200J6W7_9ENTE/79-164 AC A0A200J6W7.1
#=GS A0A941ANM8_9BACI/77-166 AC A0A941ANM8.1
#=GS A0A140DX49_9FIRM/75-158 AC A0A140DX49.1
#=GS A0A3L7JUV3_9BACI/74-166 AC A0A3L7JUV3.1
#=GS A0A5B7TG08_9CLOT/82-171 AC A0A5B7TG08.1
#=GS A0A920C7U3_9BACI/85-165 AC A0A920C7U3.1
#=GS A0A437K9Q9_9BACI/92-169 AC A0A437K9Q9.1
#=GS I6L8Y6_STRMU/81-164 AC I6L8Y6.1
#=GS A0A916WF83_9BACI/82-170 AC A0A916WF83.1
#=GS A0A917A4B0_9STRE/89-170 AC A0A917A4B0.1
#=GS A0A174GEL5_9CLOT/94-176 AC A0A174GEL5.1
#=GS A0A4R6U031_9BACI/83-168 AC A0A4R6U031.1
#=GS A0A2U3ANR0_9BACL/70-156 AC A0A2U3ANR0.1
#=GS E5WGD3_9BACI/87-168 AC E5WGD3.1
#=GS A0A1H3SUR1_9BACI/75-158 AC A0A1H3SUR1.1
#=GS A0A2I7SSD7_LACSH/76-165 AC A0A2I7SSD7.1
#=GS A0A0X8H175_9FIRM/74-159 AC A0A0X8H175.1
#=GS A0A0R2I2T4_CARDV/82-169 AC A0A0R2I2T4.1
#=GS N9VD69_CLOIN/67-151 AC N9VD69.1
#=GS A0A2N5M1C7_9BACI/89-166 AC A0A2N5M1C7.1
#=GS E7FXA5_ERYRH/73-163 AC E7FXA5.1
#=GS A0A1L8TMB7_9ENTE/76-161 AC A0A1L8TMB7.1
#=GS A0A940SV28_9ENTE/78-165 AC A0A940SV28.1
#=GS A0A430A6D8_9ENTE/81-167 AC A0A430A6D8.1
#=GS A0A1V2M862_9FIRM/80-159 AC A0A1V2M862.1
#=GS A0A0M3DE13_9CLOT/73-161 AC A0A0M3DE13.1
#=GS A0A942U0T4_9BACI/87-165 AC A0A942U0T4.1
#=GS A0A4R1J9Z9_9GAMM/88-170 AC A0A4R1J9Z9.1
#=GS A0A091CCK9_9ENTE/50-134 AC A0A091CCK9.1
#=GS A0A3D8ZYY9_9ENTE/67-163 AC A0A3D8ZYY9.1
#=GS R3U159_9ENTE/74-162 AC R3U159.1
#=GS A0A412FQ36_9FIRM/80-156 AC A0A412FQ36.1
#=GS R2QGK8_9ENTE/25-111 AC R2QGK8.1
#=GS A0A2C9XRW3_9ENTE/78-164 AC A0A2C9XRW3.1
#=GS A0A942TSR0_9BACI/3-79 AC A0A942TSR0.1
#=GS A0A430B3J7_9ENTE/82-163 AC A0A430B3J7.1
#=GS A0A1M6K7Q5_9CLOT/96-186 AC A0A1M6K7Q5.1
#=GS A0A4R9C2Q1_9FIRM/70-159 AC A0A4R9C2Q1.1
#=GS A0A2V2FZG2_9FIRM/87-172 AC A0A2V2FZG2.1
#=GS A0A4Y9AFV9_9BACI/10-99 AC A0A4Y9AFV9.1
#=GS A0A0R2MXG2_9LACO/92-174 AC A0A0R2MXG2.1
#=GS F4BSI0_CARS1/73-159 AC F4BSI0.1
#=GS A0A172Q9M2_9STRE/67-163 AC A0A172Q9M2.1
#=GS A0A143YXR6_9LACT/80-164 AC A0A143YXR6.1
#=GS F7NGA1_9FIRM/95-165 AC F7NGA1.1
#=GS A0A071LTB3_9ENTR/91-170 AC A0A071LTB3.1
#=GS A0A1T4PYR0_9FIRM/66-162 AC A0A1T4PYR0.1
#=GS K8EWR0_CARML/77-162 AC K8EWR0.1
#=GS A0A1T4M0W5_9ENTE/94-166 AC A0A1T4M0W5.1
#=GS A0A024QD92_9BACI/69-168 AC A0A024QD92.1
#=GS A0A919VET1_9CLOT/83-167 AC A0A919VET1.1
#=GS A0A099VYN7_9LIST/4-72 AC A0A099VYN7.1
#=GS K8E534_CARML/75-161 AC K8E534.2
#=GS F4BPN5_CARS1/84-173 AC F4BPN5.1
#=GS Q185K7_CLOD6/84-173 AC Q185K7.2
#=GS A0A0R1HGK8_9LACO/63-147 AC A0A0R1HGK8.1
#=GS A0A429ZYU8_9ENTE/82-163 AC A0A429ZYU8.1
#=GS R3WIR0_9ENTE/85-161 AC R3WIR0.1
#=GS A0A396L9P3_9FIRM/94-171 AC A0A396L9P3.1
#=GS A0A917HIJ0_9BACI/83-172 AC A0A917HIJ0.1
#=GS A0A347ZVI9_9CHLR/79-160 AC A0A347ZVI9.1
#=GS K8EMU9_CARML/72-156 AC K8EMU9.2
#=GS A0A942TTG0_9BACI/63-172 AC A0A942TTG0.1
#=GS A0A014PTV9_9GAMM/83-166 AC A0A014PTV9.1
#=GS A0A0A6VFY2_9BACI/93-170 AC A0A0A6VFY2.1
#=GS A0A239SR57_9STRE/65-152 AC A0A239SR57.1
#=GS A0A1M4UXL7_9FIRM/74-169 AC A0A1M4UXL7.1
#=GS A0A1T4X886_9CLOT/80-170 AC A0A1T4X886.1
#=GS A0A1I4HWH2_9BACI/83-165 AC A0A1I4HWH2.1
#=GS U2DGH2_9FIRM/83-165 AC U2DGH2.1
#=GS A0A939HCN5_9CLOT/81-167 AC A0A939HCN5.1
#=GS Q038X8_LACP3/80-165 AC Q038X8.1
#=GS F4LS34_TEPAE/86-163 AC F4LS34.1
#=GS A0A430ADD0_9ENTE/73-160 AC A0A430ADD0.1
#=GS A0A7W2ATQ5_9BACL/85-172 AC A0A7W2ATQ5.1
#=GS B1CAC3_9FIRM/61-156 AC B1CAC3.1
#=GS A0A151ANR9_9CLOT/77-164 AC A0A151ANR9.1
#=GS U2PWH2_9CLOT/83-168 AC U2PWH2.1
#=GS R5LQ80_9CLOT/96-170 AC R5LQ80.1
#=GS A0A4Y3JNN1_9ENTE/77-161 AC A0A4Y3JNN1.1
#=GS A0A4Y9J5L8_9LACT/1-60 AC A0A4Y9J5L8.1
#=GS C9AAH6_ENTCA/80-168 AC C9AAH6.1
#=GS A0A4V3A318_9LACO/58-145 AC A0A4V3A318.1
#=GS A0A848C0C0_9FUSO/86-160 AC A0A848C0C0.1
#=GS A0A1L8TPA1_9ENTE/59-145 AC A0A1L8TPA1.1
#=GS W0HMW3_9GAMM/76-164 AC W0HMW3.1
#=GS F2I6T5_AERUA/80-163 AC F2I6T5.1
#=GS A0A1Y4AJE7_9ACTN/97-182 AC A0A1Y4AJE7.1
#=GS A0A3P1VF75_9STRE/77-161 AC A0A3P1VF75.1
#=GS S3AQB0_9ACTN/79-164 AC S3AQB0.1
#=GS A0A240CBI8_SERFI/79-167 AC A0A240CBI8.1
#=GS A0A430ANA8_9ENTE/6-81 AC A0A430ANA8.1
#=GS A0A0X8F7Z0_9LACT/84-164 AC A0A0X8F7Z0.1
#=GS A0A179EQI7_ENTTH/79-163 AC A0A179EQI7.1
#=GS A0A8E2IAT5_9BACI/80-167 AC A0A8E2IAT5.1
#=GS A0A1Y4TAM0_9FIRM/75-146 AC A0A1Y4TAM0.1
#=GS A0A916VEN0_9FIRM/4-79 AC A0A916VEN0.1
#=GS H2IU74_RAHAC/84-168 AC H2IU74.1
#=GS A0A220U747_9BACI/88-188 AC A0A220U747.1
#=GS A0A0A1MMA5_9BACI/75-164 AC A0A0A1MMA5.1
#=GS F2I4P5_AERUA/72-148 AC F2I4P5.1
#=GS A0A6G7XXF2_9FIRM/80-155 AC A0A6G7XXF2.1
#=GS N9VD97_CLOIN/92-170 AC N9VD97.1
#=GS A0A370GP97_9BACI/85-166 AC A0A370GP97.1
#=GS H3NIL0_9LACT/72-158 AC H3NIL0.1
#=GS A0A1V2M6Z9_9FIRM/65-162 AC A0A1V2M6Z9.1
#=GS A0A0H3MVM9_STRS4/77-161 AC A0A0H3MVM9.1
#=GS A0A179ERW5_ENTTH/76-163 AC A0A179ERW5.1
#=GS A0A6V8SD75_9CLOT/81-171 AC A0A6V8SD75.1
#=GS A0A7V9Z5N3_9BACI/84-166 AC A0A7V9Z5N3.1
#=GS A0A1L8TN14_9ENTE/76-164 AC A0A1L8TN14.1
#=GS A0A200J040_9ENTE/77-161 AC A0A200J040.1
#=GS A0A1H8QH47_9BACI/70-155 AC A0A1H8QH47.1
#=GS A0A430B1T9_9ENTE/77-139 AC A0A430B1T9.1
#=GS A0A934WU30_9FIRM/1-53 AC A0A934WU30.1
#=GS A0A220U322_9BACI/75-165 AC A0A220U322.1
#=GS A0A096B1M4_FLAPL/1-50 AC A0A096B1M4.1
#=GS I9DE69_9FIRM/79-167 AC I9DE69.1
#=GS A0A923LF96_9FIRM/71-155 AC A0A923LF96.1
#=GS A0A242K677_9ENTE/76-162 AC A0A242K677.1
#=GS R9LNK2_9FIRM/66-160 AC R9LNK2.1
#=GS A0A224X4G5_9LACT/76-163 AC A0A224X4G5.1
#=GS U7VDU3_9FUSO/55-142 AC U7VDU3.1
#=GS A0A942YWQ6_9BACI/84-171 AC A0A942YWQ6.1
#=GS A0A920DAI0_9BACL/85-169 AC A0A920DAI0.1
#=GS A0A192H201_9LACO/81-165 AC A0A192H201.1
#=GS E7MN35_9FIRM/78-164 AC E7MN35.1
#=GS A0A200J791_9ENTE/85-172 AC A0A200J791.1
#=GS A0A0P6XSG2_9CHLR/89-168 AC A0A0P6XSG2.1
#=GS A0A242JVJ8_9ENTE/82-168 AC A0A242JVJ8.1
#=GS A0A200J0F0_9ENTE/81-165 AC A0A200J0F0.1
#=GS A0A1X6WKJ3_9ENTE/91-172 AC A0A1X6WKJ3.1
#=GS A0A2C6DL93_9GAMM/79-167 AC A0A2C6DL93.1
#=GS A0A6G1X4Z5_9BACI/87-166 AC A0A6G1X4Z5.1
#=GS A0A916Q8F4_9FIRM/100-173 AC A0A916Q8F4.1
#=GS E7MQV7_9FIRM/72-164 AC E7MQV7.1
#=GS A0A1A5XGJ3_9BACL/78-166 AC A0A1A5XGJ3.1
#=GS A0A1H2QRD1_9BACI/93-164 AC A0A1H2QRD1.1
#=GS Q99YJ1_STRP1/77-161 AC Q99YJ1.1
#=GS A0A2H6CTL6_TETHA/78-162 AC A0A2H6CTL6.1
#=GS R2SAC9_9ENTE/79-164 AC R2SAC9.1
#=GS A0A0B7GVE6_TREPH/7-84 AC A0A0B7GVE6.1
#=GS A0A412G4H2_9FIRM/72-164 AC A0A412G4H2.1
#=GS A0A940PG84_9ENTE/79-162 AC A0A940PG84.1
#=GS A0A2T4Z9A3_9BACL/78-164 AC A0A2T4Z9A3.1
#=GS A0A6A8D7G0_9BACI/78-164 AC A0A6A8D7G0.1
#=GS A0A250B2T6_9GAMM/78-166 AC A0A250B2T6.1
#=GS R2QLM8_9ENTE/79-165 AC R2QLM8.1
#=GS W9APS6_9BACI/83-170 AC W9APS6.1
#=GS A0A2N5H3C8_9BACI/81-170 AC A0A2N5H3C8.1
#=GS A0A7G9S1K5_9FIRM/80-167 AC A0A7G9S1K5.1
#=GS V6IYY8_9BACL/83-159 AC V6IYY8.1
#=GS A0A430B120_9ENTE/73-158 AC A0A430B120.1
#=GS A0A391P7V7_9FIRM/88-174 AC A0A391P7V7.1
#=GS A0A920C315_9BACI/67-171 AC A0A920C315.1
#=GS A0A084JAY6_9FIRM/75-154 AC A0A084JAY6.1
#=GS A0A1X7MQ57_9LACT/82-172 AC A0A1X7MQ57.1
#=GS A0A927QTA7_9BACL/77-165 AC A0A927QTA7.1
#=GS C8NF95_9LACT/83-167 AC C8NF95.1
#=GS A0A931F823_9ENTE/72-155 AC A0A931F823.1
#=GS A0A437KCJ5_9BACI/66-152 AC A0A437KCJ5.1
#=GS A0A0R1HMU2_9LACO/9-69 AC A0A0R1HMU2.1
#=GS A0A0R2I4Q0_CARDV/78-165 AC A0A0R2I4Q0.1
#=GS A0A2X3GKI6_9LIST/73-159 AC A0A2X3GKI6.1
#=GS A0A942YPS8_9BACI/81-163 AC A0A942YPS8.1
#=GS Q9A1L0_STRP1/71-157 AC Q9A1L0.1
#=GS G7MD94_9CLOT/64-168 AC G7MD94.1
#=GS A0A975KS39_9BACL/77-165 AC A0A975KS39.1
#=GS A0A1Q9PM46_9BACI/60-160 AC A0A1Q9PM46.1
#=GS H3S9I5_9BACL/1-55 AC H3S9I5.1
#=GS A0A1G4FP17_9FIRM/88-164 AC A0A1G4FP17.1
#=GS A0A2I1K5V9_9LACT/75-161 AC A0A2I1K5V9.1
#=GS E0NHD0_PEDAC/91-169 AC E0NHD0.1
#=GS K6CQX1_9BACI/77-166 AC K6CQX1.1
#=GS A0A143YTX7_9LACT/89-166 AC A0A143YTX7.1
#=GS E4RK49_HALHG/77-168 AC E4RK49.1
#=GS B0N368_9FIRM/79-169 AC B0N368.1
#=GS A0A416JIJ6_9FIRM/81-175 AC A0A416JIJ6.1
#=GS A0A0D0SBG3_9FIRM/70-165 AC A0A0D0SBG3.1
#=GS A0A1Y3XCF4_9FIRM/1-55 AC A0A1Y3XCF4.1
#=GS A0A2X3J623_9LIST/63-153 AC A0A2X3J623.1
#=GS A0A4Z0GMW4_9BACL/122-191 AC A0A4Z0GMW4.1
#=GS A0A0H2ZQ44_STRP2/71-158 AC A0A0H2ZQ44.1
#=GS C9A9A3_ENTCA/78-162 AC C9A9A3.1
#=GS R3TSH1_9ENTE/76-162 AC R3TSH1.1
#=GS A0A1L8WQK0_9ENTE/77-161 AC A0A1L8WQK0.1
#=GS A0A4Y9A9N2_9BACI/84-171 AC A0A4Y9A9N2.1
#=GS A0A0M3DCZ3_9CLOT/83-163 AC A0A0M3DCZ3.1
#=GS A0A3E2WAF2_9FIRM/84-163 AC A0A3E2WAF2.1
#=GS A0A075R5N4_BRELA/74-149 AC A0A075R5N4.1
#=GS A0A0R1RLM1_9LACO/109-189 AC A0A0R1RLM1.1
#=GS I6SVF2_ENTHA/81-160 AC I6SVF2.1
#=GS A0A267MG31_9CLOT/76-164 AC A0A267MG31.1
#=GS A0A917W1C3_9BACL/74-159 AC A0A917W1C3.1
#=GS A0A917XTG6_9BACI/82-171 AC A0A917XTG6.1
#=GS A0A420VIY1_9BACI/80-167 AC A0A420VIY1.1
#=GS A0A1H8U9L6_9FIRM/85-170 AC A0A1H8U9L6.1
#=GS A0A917HQL6_9BACI/68-171 AC A0A917HQL6.1
#=GS A0A1G4FMV2_9FIRM/68-163 AC A0A1G4FMV2.1
#=GS A0A0R2HXX5_CARDV/72-157 AC A0A0R2HXX5.1
#=GS A0A2I0FVQ0_9GAMM/85-166 AC A0A2I0FVQ0.1
#=GS A0A1Y3XPS4_9ACTN/95-172 AC A0A1Y3XPS4.1
#=GS A0A0F4LP91_9LACO/98-166 AC A0A0F4LP91.1
#=GS A0A1E5KXC7_9ENTE/92-180 AC A0A1E5KXC7.1
#=GS A0A7W2IZG7_9CLOT/7-78 AC A0A7W2IZG7.1
#=GS A0A6G7Y112_9FIRM/76-173 AC A0A6G7Y112.1
#=GS A0A6N4TJI4_9FIRM/91-166 AC A0A6N4TJI4.1
#=GS A0A3D8ZY39_9ENTE/73-159 AC A0A3D8ZY39.1
#=GS I6SB47_ENTHA/85-170 AC I6SB47.1
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A0A1E8GLB0_9LACT/76-160 ......................................a-NLNLDIIITHYI..LN................S..I.E...F.K....M..........L..N.Y..L.L............Y..N....Q..K..F..S..T..I.Q..L.TR..............EL.SISES..SV.FR.K.IK.RI..N.F..F..L..D...E..F...D...I...S..I.....--K...N...G...R...I..I...G.D.E..L.Q.VR.YF.YFLLY..............................
#=GC SS_cons ......................................C-CS-THHHHHHHH..HC................S..H.H...H.H....H..........H..H.H..H.H............H..H....S..C..E..E..H..H.H..H.HH..............HH.T--HH..HH.HH.H.HH.HH..H.H..H..H..H..TC..C...T...E...E..EE...EETT...T...T...E...E..E...S.-.H..H.H.HH.HH.HHHHCH.............................
#=GC seq_cons .....................................tt................t................p........h......l..........h..p.h..l.h............p..p....p.....h..s..l..p.c..l.uc..............ch.hlScu..Tl.tp.c.lc.pl..c.p..h..L..p...p..a...s...L...p..l....pppp...s...h...p...l..p...G.s.E..h.p.lR.hh.h....h.............................
//
