#=GF ID Mga
#=GF AC PF05043.16
#=GF DE Mga helix-turn-helix domain
#=GF AU Moxon SJ;0000-0003-4644-1816
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Pfam-B_5126 (release 7.7)
#=GF GA 21.10 21.10;
#=GF TC 21.10 21.10;
#=GF NC 21.00 21.00;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF WK Mga_(protein)
#=GF CL CL0123
#=GF RN [1]
#=GF RM 11952907
#=GF RT Two DNA-binding domains of Mga are required for virulence gene
#=GF RT activation in the group A streptococcus.
#=GF RA McIver KS, Myles RL;
#=GF RL Mol Microbiol 2002;43:1591-1601.
#=GF RN [2]
#=GF RM 11988525
#=GF RT Group A streptococcal RofA-type global regulators exhibit a
#=GF RT strain-specific genomic presence and regulation pattern.
#=GF RA Kreikemeyer B, Beckert S, Braun-Kiewnick A, Podbielski A;
#=GF RL Microbiology 2002;148:1501-1511.
#=GF DR INTERPRO; IPR007737;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC M regulator protein trans-acting positive regulator (Mga) is a
#=GF CC DNA-binding protein that activates the expression of several
#=GF CC important virulence genes in group A streptococcus in response
#=GF CC to changing environmental conditions [1]. This domain is found
#=GF CC in the centre of the Mga proteins. This family also contains a
#=GF CC number of bacterial RofA transcriptional regulators that seem to
#=GF CC be largely restricted to streptococci. These proteins have been
#=GF CC shown to regulate the expression of important bacterial adhesins
#=GF CC [2]. This is presumably a DNA-binding domain.
#=GF SQ 3303
#=GS A0A174FF50_9CLOT/70-169 AC A0A174FF50.1
#=GS C9A9Q9_ENTCA/81-164 AC C9A9Q9.2
#=GS A0A0H3GHH1_KLEPH/80-166 AC A0A0H3GHH1.1
#=GS A0A1D2KV04_BROTH/7-83 AC A0A1D2KV04.1
#=GS A0A1X7DP04_9BACI/75-164 AC A0A1X7DP04.1
#=GS A0A318KXX3_9FIRM/71-155 AC A0A318KXX3.1
#=GS A0A347WL21_9LACT/76-163 AC A0A347WL21.1
#=GS A0A068LQQ0_BACMM/77-164 AC A0A068LQQ0.1
#=GS F2NAZ5_CORGP/75-162 AC F2NAZ5.1
#=GS A0A062XE97_9LACO/73-157 AC A0A062XE97.1
#=GS A0A1L8RJA3_9ENTE/60-146 AC A0A1L8RJA3.1
#=GS C8NG86_9LACT/71-158 AC C8NG86.1
#=GS A0A6G8AMS0_9ENTE/75-162 AC A0A6G8AMS0.1
#=GS A0A1H3UTT8_9BACI/68-154 AC A0A1H3UTT8.1
#=GS I8IZ25_9BACI/81-165 AC I8IZ25.1
#=GS W7ZH65_9BACI/73-158 AC W7ZH65.1
#=GS A0A0E3ZC50_9FUSO/82-169 AC A0A0E3ZC50.1
#=GS C6J1G7_9BACL/79-164 AC C6J1G7.1
#=GS A0A077ZBF5_TRITR/73-159 AC A0A077ZBF5.1
#=GS A0A1L8TLQ9_9ENTE/65-163 AC A0A1L8TLQ9.1
#=GS A0A1S8T9A1_9CLOT/72-170 AC A0A1S8T9A1.1
#=GS A0A2P2BQM8_9FIRM/79-161 AC A0A2P2BQM8.1
#=GS A0A430B981_9ENTE/77-161 AC A0A430B981.1
#=GS A0A143H8D3_9BACL/76-164 AC A0A143H8D3.1
#=GS A0A143WX38_9FIRM/71-171 AC A0A143WX38.1
#=GS Q99YJ1_STRP1/77-161 AC Q99YJ1.1
#=GS A0A242K1M5_9ENTE/67-156 AC A0A242K1M5.1
#=GS A0A5D0CUQ1_9BACL/96-173 AC A0A5D0CUQ1.1
#=GS A0A0R2CYD2_9LACO/69-160 AC A0A0R2CYD2.1
#=GS A0A3Q9B5B5_9FIRM/77-167 AC A0A3Q9B5B5.1
#=GS S4D6I4_ENTFL/79-169 AC S4D6I4.1
#=GS A0A0R1ZNT2_9LACO/87-165 AC A0A0R1ZNT2.1
#=GS C3WF15_FUSMR/64-155 AC C3WF15.1
#=GS A0A430AGA9_9ENTE/83-164 AC A0A430AGA9.1
#=GS A0A2N5G9B4_9BACI/69-170 AC A0A2N5G9B4.1
#=GS A0A1L8RGR7_9ENTE/73-161 AC A0A1L8RGR7.1
#=GS A5M8Q5_STREE/76-160 AC A5M8Q5.1
#=GS A0A024Q7T2_9BACI/99-165 AC A0A024Q7T2.1
#=GS U2PWH2_9CLOT/78-168 AC U2PWH2.1
#=GS A0A2Y9BBM7_9FIRM/82-171 AC A0A2Y9BBM7.1
#=GS R3TVC8_9ENTE/76-164 AC R3TVC8.1
#=GS Q837I4_ENTFA/79-163 AC Q837I4.1
#=GS F5X4Z2_STRPX/71-161 AC F5X4Z2.1
#=GS A0A4R2BIW4_9BACI/122-205 AC A0A4R2BIW4.1
#=GS A0A0R1RPW0_9LACO/82-166 AC A0A0R1RPW0.1
#=GS A0A089IT85_9BACL/87-167 AC A0A089IT85.1
#=GS C9A7F9_ENTCA/78-165 AC C9A7F9.1
#=GS A0A0M2VUD4_9BACL/70-158 AC A0A0M2VUD4.1
#=GS T0SDU1_LACLC/69-152 AC T0SDU1.1
#=GS J0USV7_STREE/76-160 AC J0USV7.1
#=GS A0A371AYL7_9FIRM/71-159 AC A0A371AYL7.1
#=GS A0A4P8YIW5_9ENTR/84-166 AC A0A4P8YIW5.1
#=GS N9WBG8_CLOIN/73-164 AC N9WBG8.1
#=GS A0A1H3UTN1_9BACI/68-171 AC A0A1H3UTN1.1
#=GS A0A1H2W800_9FIRM/109-189 AC A0A1H2W800.1
#=GS A0A2U3AM41_9BACL/76-169 AC A0A2U3AM41.1
#=GS A0A179EPA5_ENTTH/72-156 AC A0A179EPA5.1
#=GS A0A1B1MY37_9BACL/83-166 AC A0A1B1MY37.1
#=GS A0A3S0KDY6_9BACI/74-166 AC A0A3S0KDY6.1
#=GS E1M6G3_9STRE/71-159 AC E1M6G3.1
#=GS T0VNZ9_9ENTE/67-157 AC T0VNZ9.1
#=GS C6JQT2_FUSVA/77-164 AC C6JQT2.1
#=GS A0A098M7X8_9BACL/77-166 AC A0A098M7X8.1
#=GS A0A4R3KVI4_9FIRM/82-169 AC A0A4R3KVI4.1
#=GS F3Y8I7_MELPT/75-166 AC F3Y8I7.1
#=GS A0A1W6B5H7_9GAMM/81-166 AC A0A1W6B5H7.1
#=GS A0A1T4KPS0_9ENTE/79-165 AC A0A1T4KPS0.1
#=GS A0A378E8I7_KLEPR/80-166 AC A0A378E8I7.1
#=GS B0N1X6_9FIRM/87-165 AC B0N1X6.1
#=GS A0A1Y4BV74_9FIRM/1-55 AC A0A1Y4BV74.1
#=GS A0A2C1YM21_9BACI/86-165 AC A0A2C1YM21.1
#=GS C9A679_ENTCA/5-82 AC C9A679.1
#=GS A0A3N0I098_9FIRM/68-167 AC A0A3N0I098.1
#=GS A0A0U3MEN2_9LACT/72-162 AC A0A0U3MEN2.1
#=GS S4D7B9_ENTFL/92-163 AC S4D7B9.1
#=GS A0A5R9DWL3_9LACT/70-159 AC A0A5R9DWL3.1
#=GS A0A4U0FDC3_9BACL/101-189 AC A0A4U0FDC3.1
#=GS B9Y2V8_9FIRM/79-168 AC B9Y2V8.1
#=GS A0A6G7XWJ2_9FIRM/68-156 AC A0A6G7XWJ2.1
#=GS R2PT95_9ENTE/78-161 AC R2PT95.1
#=GS A0A1N6ZCX0_9BACI/77-164 AC A0A1N6ZCX0.1
#=GS A0A0K8JKB1_9FIRM/86-169 AC A0A0K8JKB1.1
#=GS G5ICP5_9CLOT/82-168 AC G5ICP5.1
#=GS A0A542AQ96_9CLOT/90-171 AC A0A542AQ96.1
#=GS A0A1J7D1B1_9GAMM/94-167 AC A0A1J7D1B1.1
#=GS A0A1L8RE76_9ENTE/76-163 AC A0A1L8RE76.1
#=GS A0A433HPJ5_9BACI/1-58 AC A0A433HPJ5.1
#=GS A0A1T4N359_9FIRM/99-202 AC A0A1T4N359.1
#=GS A0A2C1YM37_9BACI/80-166 AC A0A2C1YM37.1
#=GS Q3XZP5_ENTFD/91-175 AC Q3XZP5.1
#=GS Q2G2B8_STAA8/69-167 AC Q2G2B8.1
#=GS A0A0F2C6U0_9MICO/81-155 AC A0A0F2C6U0.1
#=GS A0A0A2TDB7_9BACI/76-164 AC A0A0A2TDB7.1
#=GS A0A429ZQP9_9ENTE/71-157 AC A0A429ZQP9.1
#=GS A0A0R1H3K7_9LACO/32-117 AC A0A0R1H3K7.1
#=GS A0A1S6IQC9_9LACT/77-161 AC A0A1S6IQC9.1
#=GS G5JQR4_STRCG/5-77 AC G5JQR4.1
#=GS A0A1M5Y7P9_9CLOT/82-171 AC A0A1M5Y7P9.1
#=GS R2TCV4_9ENTE/83-165 AC R2TCV4.1
#=GS A0A430AXK9_9ENTE/77-161 AC A0A430AXK9.1
#=GS A0A0R2I0M3_CARDV/82-167 AC A0A0R2I0M3.1
#=GS A0A6G8APD3_9ENTE/83-167 AC A0A6G8APD3.1
#=GS D9QZD8_CLOSW/68-160 AC D9QZD8.1
#=GS D4MUJ7_ANAHA/57-138 AC D4MUJ7.1
#=GS A0A4P6YSQ4_9LACO/71-157 AC A0A4P6YSQ4.1
#=GS U5SDI8_9LACT/77-161 AC U5SDI8.1
#=GS S4DA91_ENTFL/85-169 AC S4DA91.1
#=GS A0A0R2MX12_9LACO/47-132 AC A0A0R2MX12.1
#=GS A0A1T4PYR0_9FIRM/82-162 AC A0A1T4PYR0.1
#=GS A0A430AKU9_9ENTE/86-165 AC A0A430AKU9.1
#=GS E3EB07_PAEPS/84-167 AC E3EB07.1
#=GS A0A1Q9PIS1_9BACI/77-166 AC A0A1Q9PIS1.1
#=GS A0A380LRD2_9FIRM/68-166 AC A0A380LRD2.1
#=GS A0A3S2X7D0_9BACI/118-206 AC A0A3S2X7D0.1
#=GS A0A1H3VTK8_9BACI/85-167 AC A0A1H3VTK8.1
#=GS A0A024P7U9_9BACI/79-167 AC A0A024P7U9.1
#=GS A0A090IX30_9BACI/71-173 AC A0A090IX30.1
#=GS R3WSA3_9ENTE/77-161 AC R3WSA3.1
#=GS A0A267MLB5_9CLOT/101-193 AC A0A267MLB5.1
#=GS F2I7T9_AERUA/89-171 AC F2I7T9.1
#=GS W7BYW2_9LIST/78-159 AC W7BYW2.1
#=GS A0A345PJU9_9BACI/66-171 AC A0A345PJU9.1
#=GS A0A511A9G0_9MICO/82-155 AC A0A511A9G0.1
#=GS A0A1E5KX99_9ENTE/79-164 AC A0A1E5KX99.1
#=GS A0A4R9BCI4_9MICO/80-163 AC A0A4R9BCI4.1
#=GS A0A430A8G0_9ENTE/88-174 AC A0A430A8G0.1
#=GS A0A150LG06_9BACI/82-166 AC A0A150LG06.1
#=GS W9ALJ7_9BACI/77-164 AC W9ALJ7.1
#=GS A0A1Q9JZM3_9FIRM/1-54 AC A0A1Q9JZM3.1
#=GS A0A443IAA0_9GAMM/79-166 AC A0A443IAA0.1
#=GS N4WC59_9BACI/67-165 AC N4WC59.1
#=GS A0A1W1Z4N1_9FIRM/3-49 AC A0A1W1Z4N1.1
#=GS A0A2I8QA87_9ENTR/85-166 AC A0A2I8QA87.1
#=GS A0A3Q8SCM9_9BACL/79-163 AC A0A3Q8SCM9.1
#=GS A0A1L8TMT3_9ENTE/79-166 AC A0A1L8TMT3.1
#=GS A0A1M4VE17_9LACT/71-157 AC A0A1M4VE17.1
#=GS A0A1U7NDF5_9FIRM/77-170 AC A0A1U7NDF5.1
#=GS K8E5F2_CARML/76-163 AC K8E5F2.1
#=GS A0A1L8TPJ7_9ENTE/85-172 AC A0A1L8TPJ7.1
#=GS D1AHL2_SEBTE/63-160 AC D1AHL2.1
#=GS A0A4Y9ADL3_9BACI/75-162 AC A0A4Y9ADL3.1
#=GS A0A2P8VMX4_9ENTR/85-166 AC A0A2P8VMX4.1
#=GS A0A252F212_9CLOT/31-119 AC A0A252F212.1
#=GS A0A1H8QUU4_9BACI/85-165 AC A0A1H8QUU4.1
#=GS T0U2H0_9ENTE/85-170 AC T0U2H0.1
#=GS A0A1L8QXP1_9ENTE/88-175 AC A0A1L8QXP1.1
#=GS A0A1E5KU99_9ENTE/72-157 AC A0A1E5KU99.1
#=GS A0A542AQB6_9CLOT/92-171 AC A0A542AQB6.1
#=GS A0A0U4H9L2_9MICO/81-155 AC A0A0U4H9L2.1
#=GS A0A1E5KS46_9ENTE/81-168 AC A0A1E5KS46.1
#=GS A0A1Y3U7H9_9ACTN/109-190 AC A0A1Y3U7H9.1
#=GS A0A4V1W6Y2_9BACL/86-165 AC A0A4V1W6Y2.1
#=GS K8E1P1_CARML/76-162 AC K8E1P1.1
#=GS A0A075LUC7_9BACI/68-171 AC A0A075LUC7.1
#=GS A0A224WWD6_9LACT/73-161 AC A0A224WWD6.1
#=GS A0A1E5L0I3_9ENTE/78-165 AC A0A1E5L0I3.1
#=GS A0A224X4G5_9LACT/76-163 AC A0A224X4G5.1
#=GS D6XZQ1_BACIE/81-165 AC D6XZQ1.1
#=GS ATXA_BACAN/75-160 AC Q44636.2
#=GS ATXA_BACAN/75-160 DR PDB; 4R6I B; 75-160;
#=GS ATXA_BACAN/75-160 DR PDB; 4R6I A; 75-160;
#=GS A0A098F515_9BACI/98-167 AC A0A098F515.1
#=GS A0A0R1ZNX6_9LACO/122-208 AC A0A0R1ZNX6.1
#=GS A0A6S6QUA3_9FIRM/72-167 AC A0A6S6QUA3.1
#=GS Q04H56_OENOB/79-160 AC Q04H56.1
#=GS Q8Y410_LISMO/87-163 AC Q8Y410.1
#=GS E3EAA6_PAEPS/67-167 AC E3EAA6.1
#=GS W9APS6_9BACI/68-170 AC W9APS6.1
#=GS A0A1E5KXR1_9ENTE/81-164 AC A0A1E5KXR1.1
#=GS I4D6N2_DESAJ/2-74 AC I4D6N2.1
#=GS A0A4R6N4K4_9BACL/67-167 AC A0A4R6N4K4.1
#=GS A0A1B8WHQ9_9BACI/78-164 AC A0A1B8WHQ9.1
#=GS A0A0A7FX30_9CLOT/73-164 AC A0A0A7FX30.1
#=GS Q65DG1_BACLD/68-167 AC Q65DG1.1
#=GS A0A1S8TNL0_9CLOT/74-170 AC A0A1S8TNL0.1
#=GS W4U583_CUTAC/67-145 AC W4U583.1
#=GS S0KNF5_ENTAV/72-168 AC S0KNF5.1
#=GS A0A1T4PYA1_9FIRM/66-163 AC A0A1T4PYA1.1
#=GS A0A2P6MLE9_9BACI/71-164 AC A0A2P6MLE9.1
#=GS C0CTD3_9FIRM/115-190 AC C0CTD3.1
#=GS A0A0F4LP91_9LACO/98-167 AC A0A0F4LP91.1
#=GS A0A0R2BXY2_9LACO/66-162 AC A0A0R2BXY2.1
#=GS A0A4R9C2Q1_9FIRM/70-159 AC A0A4R9C2Q1.1
#=GS A0A6L9XVX1_9MICO/88-165 AC A0A6L9XVX1.1
#=GS S4E0K0_ENTFL/38-118 AC S4E0K0.1
#=GS Q62YQ4_BACLD/67-155 AC Q62YQ4.1
#=GS A0A0R1NA43_9LACO/80-151 AC A0A0R1NA43.1
#=GS A0A1S8T9V1_9CLOT/97-182 AC A0A1S8T9V1.1
#=GS B0N8A6_9FIRM/70-160 AC B0N8A6.1
#=GS A0A6G1X4Z5_9BACI/85-166 AC A0A6G1X4Z5.1
#=GS S0SEJ2_ENTAV/87-172 AC S0SEJ2.1
#=GS A0A4R7L0E1_9FUSO/76-165 AC A0A4R7L0E1.1
#=GS S4DAT6_ENTFL/76-162 AC S4DAT6.1
#=GS C9AAG6_ENTCA/79-165 AC C9AAG6.2
#=GS A0A097QZM1_HAFAL/67-166 AC A0A097QZM1.1
#=GS A0A1M4YKT4_9FIRM/84-166 AC A0A1M4YKT4.1
#=GS A0A0A5GJ24_9BACI/78-167 AC A0A0A5GJ24.1
#=GS E4KN50_9LACT/1-74 AC E4KN50.1
#=GS A0A0B0CZ51_9BACI/70-170 AC A0A0B0CZ51.1
#=GS R7RPZ8_9CLOT/68-168 AC R7RPZ8.1
#=GS A0A3L8GI98_STRIN/77-172 AC A0A3L8GI98.1
#=GS B5CR43_9FIRM/77-165 AC B5CR43.1
#=GS A0A221M9G7_9BACI/71-163 AC A0A221M9G7.1
#=GS K6TYJ5_9CLOT/7-75 AC K6TYJ5.1
#=GS B1C6X4_9FIRM/84-153 AC B1C6X4.1
#=GS A0A421BG38_9LACT/85-160 AC A0A421BG38.1
#=GS A0A075K8M0_9FIRM/86-170 AC A0A075K8M0.1
#=GS A0A1L8ZF06_9BACI/63-152 AC A0A1L8ZF06.1
#=GS Q5WJH1_BACSK/66-164 AC Q5WJH1.1
#=GS Q03T91_LACBA/72-158 AC Q03T91.1
#=GS A0A2X3HHW7_9LIST/82-168 AC A0A2X3HHW7.1
#=GS Q8ZK41_SALTY/87-167 AC Q8ZK41.1
#=GS A0A179ER80_ENTTH/86-170 AC A0A179ER80.1
#=GS A0A1Q9PM46_9BACI/60-160 AC A0A1Q9PM46.1
#=GS R3U5V4_9ENTE/81-168 AC R3U5V4.1
#=GS A8AVC7_STRGC/73-163 AC A8AVC7.1
#=GS A0A419T9V9_9CLOT/69-168 AC A0A419T9V9.1
#=GS A0A1G5KPA8_9CLOT/75-161 AC A0A1G5KPA8.1
#=GS A0A0G3CSE3_9GAMM/80-167 AC A0A0G3CSE3.1
#=GS A0A4D7CSH3_9ENTE/78-166 AC A0A4D7CSH3.1
#=GS A0A377KM66_9ENTE/73-156 AC A0A377KM66.1
#=GS R6GSR4_9FIRM/4-74 AC R6GSR4.1
#=GS A0A0R2HYI9_CARDV/78-163 AC A0A0R2HYI9.1
#=GS B9YDF9_9FIRM/96-172 AC B9YDF9.1
#=GS A0A1Q9K2K7_9FIRM/8-79 AC A0A1Q9K2K7.1
#=GS A0A2C1Z1Q5_9BACI/69-168 AC A0A2C1Z1Q5.1
#=GS Q831K2_ENTFA/79-164 AC Q831K2.1
#=GS A0A0R1QXN2_9LACO/95-180 AC A0A0R1QXN2.1
#=GS A0A6A7K8Q8_9FIRM/82-171 AC A0A6A7K8Q8.1
#=GS A0A430B938_9ENTE/83-168 AC A0A430B938.1
#=GS A0A1I1N7K8_9CLOT/84-165 AC A0A1I1N7K8.1
#=GS S0LHE8_ENTAV/63-165 AC S0LHE8.1
#=GS A0A0U9HFK9_9FIRM/87-163 AC A0A0U9HFK9.1
#=GS S0L410_ENTAV/80-167 AC S0L410.1
#=GS E7MQ67_9FIRM/80-166 AC E7MQ67.1
#=GS K8E6C0_CARML/79-164 AC K8E6C0.2
#=GS A0A1H2XRL6_9BACI/86-165 AC A0A1H2XRL6.1
#=GS A0A429ZVB5_9ENTE/81-168 AC A0A429ZVB5.1
#=GS A0A0X8H175_9FIRM/74-159 AC A0A0X8H175.1
#=GS H3NQ78_9FIRM/3-73 AC H3NQ78.1
#=GS A0A0R2CFN9_9LACO/8-83 AC A0A0R2CFN9.1
#=GS A0A3R7DI77_9MICO/81-154 AC A0A3R7DI77.1
#=GS A0A1L8WPE6_9ENTE/80-163 AC A0A1L8WPE6.1
#=GS A0A0R1QE13_9LACO/78-159 AC A0A0R1QE13.1
#=GS V9HFS8_9CLOT/66-161 AC V9HFS8.1
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