#=GF ID Mlp
#=GF AC PF03304.18
#=GF DE Mlp lipoprotein family
#=GF PI Lipoprotein_12;
#=GF AU Mifsud W;0000-0002-9805-6461
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Pfam-B_1663 (release 6.5)
#=GF GA 21.00 21.00;
#=GF TC 21.00 21.10;
#=GF NC 20.90 20.90;
#=GF BM hmmbuild --aminoHMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 81514348 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 9488385
#=GF RT A monoclonal antibody generated by antigen inoculation via tick
#=GF RT bite is reactive to the Borrelia burgdorferi Rev protein, a
#=GF RT member of the 2.9 gene family locus.
#=GF RA Gilmore RD Jr, Mbow ML;
#=GF RL Infect Immun 1998;66:980-986.
#=GF RN [2]
#=GF RM 10531261
#=GF RT Identification, characterization, and expression of three new
#=GF RT members of the Borrelia burgdorferi Mlp (2.9) lipoprotein gene
#=GF RT family.
#=GF RA Yang X, Popova TG, Hagman KE, Wikel SK, Schoeler GB, Caimano MJ,
#=GF RA Radolf JD, Norgard MV;
#=GF RL Infect Immun 1999;67:6008-6018.
#=GF DR INTERPRO; IPR004983;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC The Mlp (for Multicopy Lipoprotein) family of lipoproteins is
#=GF CC found in Borrelia species [1]. This family were previously known
#=GF CC as 2.9 lipoprotein genes [2]. These surface expressed genes may
#=GF CC represent new candidate vaccinogens for Lyme disease [1].
#=GF CC Members of this family generally are downstream of four ORFs
#=GF CC called A,B,C and D that are involved in hemolytic activity.
#=GF SQ 22
#=GS W6TH47_9SPIR/35-183 AC W6TH47.1
#=GS W6TG38_9SPIR/29-140 AC W6TG38.1
#=GS MLPH_BORBU/30-146 AC Q9S069.1
#=GS W6TEQ3_9SPIR/78-277 AC W6TEQ3.1
#=GS W6TWD7_9SPIR/29-140 AC W6TWD7.1
#=GS MLPG_BORBU/25-140 AC Q9S083.1
#=GS W6TFP2_9SPIR/29-140 AC W6TFP2.1
#=GS L0K6W6_HALHC/18-125 AC L0K6W6.1
#=GS MLPC_BORBU/30-145 AC Q9S0H7.1
#=GS W6TJV9_9SPIR/24-113 AC W6TJV9.1
#=GS E5XV17_SEGRC/17-141 AC E5XV17.1
#=GS MLPI_BORBU/25-139 AC Q9S043.1
#=GS F2KRY5_ARCVS/45-154 AC F2KRY5.1
#=GS W6TH67_9SPIR/29-140 AC W6TH67.1
#=GS MLPA_BORBU/30-145 AC H7C7P1.1
#=GS MLPA_BORBU/30-145 DR PDB; 6QBI A; 5-99;
#=GS W6THB1_9SPIR/32-177 AC W6THB1.1
#=GS W6TGA1_9SPIR/22-141 AC W6TGA1.1
#=GS W6TG16_9SPIR/1-47 AC W6TG16.1
#=GS MLPD_BORBU/25-138 AC Q9S0E8.1
#=GS MLPJ_BORBU/30-183 AC Q9RZZ0.1
#=GS MLPF_BORBU/30-145 AC Q9S0B7.1
#=GS W6TK50_9SPIR/24-139 AC W6TK50.1
W6TH47_9SPIR/35-183 ...................................vkge----TSRVTRSIDQHDS-QN---TLTTEEKNRFESLQyamnteikaheqtlkr........................rktnpseplgelsagiiKTYKR......FIKWISddsniekqrELSDA.FKNIYNFLEQKrkklaSKQHPDMKRYIQGAFYDIQDN..............---EYKKNTNTTL--------------..---------iymvvqkikni................
W6TG38_9SPIR/29-140 ......................................n-KGIKSRNKRDLEQQVEAQK------TPEEALREKLN.........................................................DNQKK......GLDFLK.........DALSS.ESDFNNFLNED.....ESKIKDALDHIQSELAKCTG-..............DEAADKKNTFKQVVEGALKEG-LDNFK..-GQSNST--cg.........................
MLPH_BORBU/30-146 .......................................AQQTKSRRKRDLTQKEVTQE-KPKSK--EELLREKLN.........................................................DDQKT......QLDWLK.........TALTD.AGEFDKFLENN.....EDKIKSALDHIKSELDKCNGK..............ENGDVQKNTFKQVVQGALKGG-IDGFG..ASNATTTCN...........................
W6TEQ3_9SPIR/78-277 ................................tlqgaei------------VQEEDKQ-EKIVLTNEETLMLNSLLgafngiknaynhvlyypktiinvsrryskygdkfieqglallkeaydsncleytkivDNYGL......FVMWVNddp..syqkELVGA.FTKTYNFLIGKk..niHASNEDIDLYIKNAIQWYEKQfmflrdksnrikdlSRGGIYGENSKNYIYDFFSTVIRAGF-..---------rdidfskteakqsl.............
W6TWD7_9SPIR/29-140 ......................................n-KGIKSRNKRDLEQQVEAQK------TPEEALREKLN.........................................................NNQRK......GLDFLK.........EALSS.ESDFNNFLNAD.....ESKIKDALDHIQSELAKCTG-..............DEAADKKNTFKQVVEGALKEG-LDNFK..-GQSNST--cg.........................
MLPG_BORBU/25-140 .......................................TKQTKSRQKRDLTQKEATQE-KPKSKSKEDLLREKLS.........................................................DDQKT......QLDWLK.........TALTG.VGKFDKFLEND.....EGKIKSALEHIKTELDKCNG-..............--NDEGKNTFKTTVQGFFSGGNIDNF-..ADQATATCN...........................
W6TFP2_9SPIR/29-140 ......................................n-KGIKSRNKRDLEQQVEAQK------TPEEALREKLN.........................................................DSQKQ......GLDFLK.........DALSS.ESELNKFLNED.....ESKIKDALDHIQSELAKCTG-..............DNAADQKTTFKQVVKGALGGG-LDNF-..KDTASSAC-e..........................
L0K6W6_HALHC/18-125 ............................eqqgkefyqrc--------------------AKVNSKPKVKKLFTQLK.........................................................DDEEE......HYQYFK.........RLLNN.LNEEDKSLSKD.....YLYNEEVSGYLRSLVDSKVF-..............PEDEKVIDEIAHNLEEALKIG------..---------ikaeknslllyq...............
MLPC_BORBU/30-145 .......................................AQQTKRRGKRDLTQKETTQE-KPKSK--EELLREKLS.........................................................DDQKT......HLDWLK.........PALTG.AGEFDKFLEND.....DDKIKSALDHIKTQLDSCNG-..............DQAEQQKTTFKTVVTEFFKNGDIDNF-..ATGAVSNCN...........................
W6TJV9_9SPIR/24-113 ......................................n-KGIKSRNKRDLEQQVEAQK-----T-PEEDLREKLD.........................................................DNQKK......GLDFLK.........EALSN.ESDFNNFLNAD.....ESKIKEALDHIQSELVKCTGD..............NAANQKKH-------------------..---------lnk........................
E5XV17_SEGRC/17-141 ..............eqdmvavindmrgaidsgkklfddl------------------------------------Ksvddlvsakn....................................rgpadfegmlqENCKK......ALDWLC.........EHVSQ.VNQFKTWLVGD.....QEKIKASSDHWKTDLPKKLDS..............-NIWPSDDAV-KAVQDAWQGK------..---------tanavclvlka................
MLPI_BORBU/25-139 .......................................TSQTKSRQKRDLTQKEATQE-KPKSK--EDLLREKLS.........................................................EDQKT......HLDWLK.........TALTG.AGEFDKFLGYD.....EDKIKGALNHIKSELDKCTG-..............DNSEQQKSTFKEVVKGALGGG-IDSF-..ATSASSTC-q..........................
F2KRY5_ARCVS/45-154 ..................................nvira------VKERELTKKEAIQE----LNAMEQILMSDVSf.......................................................dDTLKS.....dFFDFVR.........EGLRV.VVNAAKYCVEG.....KISKKNFNTLIKEAVEKEKKG..............---------------------------..---------dfegafdtiarmgakvfkgeklpedid
W6TH67_9SPIR/29-140 ......................................n-KGIKSRNKRDLEQQVEAQK------TPEENLREKLS.........................................................DSQKQ......GLDFLK.........EALSS.GSDFNNFLNAE.....ESKIKEALDHIQSELAKCTG-..............ENAAQQKTTFKQTVKGALGGG-LDDFK..SN-VASTC-d..........................
MLPA_BORBU/30-145 .......................................AQQTKSRGKRDLTQKEATPE-KPKSK--EELLREKLS.........................................................EDQKT......HLDWLK.........EALGN.DGEFDKFLGYD.....ESKIKTALDHIKSELDKCNG-..............NDADQQKTTFKQTVQGALSGG-IDGFG..SNNAVTTC-g..........................
#=GR MLPA_BORBU/30-145 SS .......................................XXXXXXXXXXXXXXXXXXXX-XS--H--HHHHHHHS-.........................................................HHHHH......HHHHHH.........HHH-S.HHHHHHHHTS-.....HHHHHHHHHHHHHHHHT--S-..............SSHHHHHHHHHHHHHTTSSS--STT-S..TTT---TT-T..........................
W6THB1_9SPIR/32-177 apttetpqanenkkynaiingfnkkieilrkriknnsld------------------------------KIPTSVQ.........................................................EHKDRitayeqFISWIEknp..dkkkELDEA.WTEAYNLLEQRr..aeNAPEKTLAEYISDAIDCKENP.............sCQDTKKYGTQDNQINRLFGVNSVSIFI..SNN------skeif......................
W6TGA1_9SPIR/22-141 ...............................cdqekntn-KGIKSRNKRDLEQQVEAQK-----T-PEEDLREKLS.........................................................DNQRK......GLDFLK.........EALSNsESEFNKFLNAD.....ESKIKDALDHIQSELAKCTG-..............DNAANQKNTFKQVVEGALKEG-LDNF-..KDQSNSTC-g..........................
W6TG16_9SPIR/1-47 .....................................ms-------------------------------------.........................................................-----......------.........----N.ESEINKFLNED.....ESKIKEALDHIQSELAKCTGRit..........qlT----KK--------------------..---------ehskk......................
MLPD_BORBU/25-138 ......................................n-SQTKSRQKRDLTQKEATQE-KPKSK--EELLREKLN.........................................................DNQKT......HLDWLK.........EALGN.DGEFNKFLGYD.....ESKIKSALDHIKSELDSCTG-..............DK-VENKNTFKQVVQEALKGG-IDGF-..ENTASSTCK...........................
MLPJ_BORBU/30-183 .......................................AQQTKSRKKRDLSQEELPQQEKITLTSDEEKMFTSLInvfkytiek.......................................lnneiqgcmNGNKSkc..ndFFDWLSedi..qkqkELAGA.FTKVYNFLKS-.....KAQNETFDTYIKGAIDCKKNTpq..........dcNKNNKYGDGD-NLIEQYFRGVANDMSNrnSNEEIYQY-l..........................
MLPF_BORBU/30-145 .......................................AQQTKSRGKRDLTQKEATPE-KPKSK--EELLREKLS.........................................................EDQKT......HLDWLK.........EALGN.DGEFDKFLGYD.....ESKIKSALNHIKSELDKCTG-..............DNSEQQKSTFKQTVQGFFSGGNIDNF-..ANNAVSNCN...........................
W6TK50_9SPIR/24-139 ......................................n-KGIKSRNKRDLEQQVEAQK------TPEENLREKLS.........................................................ESQKQ......GLDSLK.........EALGS.GSIFNNFLNAD.....ESKIKEALDHIQSELAKCTG-..............NNASEQKGTFKTVINEYFSKMDNETLKgiKENATSACN...........................
#=GC SS_cons .......................................XXXXXXXXXXXXXXXXXXXX-XS--H--HHHHHHHS-.........................................................HHHHH......HHHHHH.........HHH-S.HHHHHHHHTS-.....HHHHHHHHHHHHHHHHT--S-..............SSHHHHHHHHHHHHHTTSSS--STT-S..TTT---TT-T..........................
#=GC seq_cons ........................................pthKSRtKRDLpQp.tsQc.....p..E-hLREKLs.........................................................-sQKp......tLDaLK.........EALss.tu-FspFLstD.....EuKIKsAL-HIpSELsKCsG...............spssppKsThKpslpthhpts.h-sF....st...t.............................
//
