#=GF ID Mlp
#=GF AC PF03304.16
#=GF DE Mlp lipoprotein family
#=GF PI Lipoprotein_12;
#=GF AU Mifsud W;0000-0002-9805-6461
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Pfam-B_1663 (release 6.5)
#=GF GA 21.00 21.00;
#=GF TC 21.30 21.00;
#=GF NC 20.60 20.50;
#=GF BM hmmbuild --amino HMM.ann SEED.ann
#=GF SM hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 9488385
#=GF RT A monoclonal antibody generated by antigen inoculation via tick
#=GF RT bite is reactive to the Borrelia burgdorferi Rev protein, a
#=GF RT member of the 2.9 gene family locus.
#=GF RA Gilmore RD Jr, Mbow ML;
#=GF RL Infect Immun 1998;66:980-986.
#=GF RN [2]
#=GF RM 10531261
#=GF RT Identification, characterization, and expression of three new
#=GF RT members of the Borrelia burgdorferi Mlp (2.9) lipoprotein gene
#=GF RT family.
#=GF RA Yang X, Popova TG, Hagman KE, Wikel SK, Schoeler GB, Caimano MJ,
#=GF RA Radolf JD, Norgard MV;
#=GF RL Infect Immun 1999;67:6008-6018.
#=GF DR INTERPRO; IPR004983;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC The Mlp (for Multicopy Lipoprotein) family of lipoproteins is
#=GF CC found in Borrelia species [1]. This family were previously known
#=GF CC as 2.9 lipoprotein genes [2]. These surface expressed genes may
#=GF CC represent new candidate vaccinogens for Lyme disease [1].
#=GF CC Members of this family generally are downstream of four ORFs
#=GF CC called A,B,C and D that are involved in hemolytic activity.
#=GF SQ 26
#=GS MLPC_BORBU/30-145 AC Q9S0H7.1
#=GS W6TGV6_9SPIR/43-185 AC W6TGV6.1
#=GS W6TH47_9SPIR/35-183 AC W6TH47.1
#=GS W6TK50_9SPIR/24-139 AC W6TK50.1
#=GS MLPF_BORBU/30-145 AC Q9S0B7.1
#=GS A0A0B4R957_9BACL/2-55 AC A0A0B4R957.1
#=GS W6TJV9_9SPIR/23-113 AC W6TJV9.1
#=GS W6TGA1_9SPIR/29-143 AC W6TGA1.1
#=GS W6THB1_9SPIR/32-179 AC W6THB1.1
#=GS W6TFP2_9SPIR/29-142 AC W6TFP2.1
#=GS MLPH_BORBU/30-146 AC Q9S069.1
#=GS MLPG_BORBU/25-140 AC Q9S083.1
#=GS W6TKF0_9SPIR/210-373 AC W6TKF0.1
#=GS O50929_BORBU/40-205 AC O50929.2
#=GS MLPD_BORBU/25-138 AC Q9S0E8.1
#=GS W6TGP4_9SPIR/18-174 AC W6TGP4.1
#=GS MLPA_BORBU/30-145 AC H7C7P1.1
#=GS MLPA_BORBU/30-145 DR PDB; 6QBI A; 5-99;
#=GS W6TH67_9SPIR/29-140 AC W6TH67.1
#=GS W6TG16_9SPIR/1-47 AC W6TG16.1
#=GS MLPJ_BORBU/30-183 AC Q9RZZ0.1
#=GS W6TG38_9SPIR/29-140 AC W6TG38.1
#=GS W6TWD7_9SPIR/29-140 AC W6TWD7.1
#=GS W6TGZ2_9SPIR/18-173 AC W6TGZ2.1
#=GS MLPI_BORBU/25-140 AC Q9S043.1
#=GS W6TEQ3_9SPIR/151-277 AC W6TEQ3.1
#=GS W6TXH2_9SPIR/39-195 AC W6TXH2.1
MLPC_BORBU/30-145 ..........................AQQTKRRGKRDLTQKETTQE-KPKSK--EELLREKLS------------.....-.--..---DDQ.KT..............----HLDWLK...-------PALTGAGEFDKFLEND..........DDKIKSALDHIKTQLDSCNG-..............DQAEQQKTTF.KTVVTEFFKNG.DIDNF---ATGAVSNCN.......................................................
W6TGV6_9SPIR/43-185 .......................fng------------------------LTSDEKLKLKTLMAGFRKIIKH---.....-.DD..QLIKAQ.KE..............QYEKFEEWLL...QDIQKQKDLADSFKYTYYFLEQDk.......pkQTKNLTIAQLVVNTIDCIVTDkcsdrn..dvydydNDNHHYKEQI.KNLFAIFLNKIlSIPNNTTNVNEKMFKC-l......................................................
W6TH47_9SPIR/35-183 ......................vkge----TSRVTRSIDQHDS-QN---TLTTEEKNRFESLQYAMNTEIKAHEQ.....T.LK..RRKTNP.SEplgel...sagiikTYKRFIKWISd.dSNIEKQRELSDAFKNIYNFLEQKrk.....klaSKQHPDMKRYIQGAFYDIQDN..............---EYKKNTN.TT---------.-----------------liymvvqkikni...........................................
W6TK50_9SPIR/24-139 .........................n-KGIKSRNKRDLEQQVEAQK-----T-PEENLREKLS------------.....-.--..---ESQ.KQ..............----GLDSLK...-------EALGSGSIFNNFLNAD..........ESKIKEALDHIQSELAKCTG-..............NNASEQKGTF.KTVINEYFSKM.DNETLKGIKENATSACN.......................................................
MLPF_BORBU/30-145 ..........................AQQTKSRGKRDLTQKEATPE-KPKSK--EELLREKLS------------.....-.--..---EDQ.KT..............----HLDWLK...-------EALGNDGEFDKFLGYD..........ESKIKSALNHIKSELDKCTG-..............DNSEQQKSTF.KQTVQGFFSGG.NIDNF---ANNAVSNCN.......................................................
A0A0B4R957_9BACL/2-55 .......................iak---------------------------------EELV-IFEYELAKLME.....E.YQ..KCVDQSlKK..............KIQEDVKWLK...TSIF-------------------..........---------------------..............----------.-----------.-----------------stgtyeqtie.............................................
W6TJV9_9SPIR/23-113 ........................tn-KGIKSRNKRDLEQQVEAQK-----T-PEEDLREKLD------------.....-.--..---DNQ.KK..............----GLDFLK...-------EALSNESDFNNFLNAD..........ESKIKEALDHIQSELVKCTGD..............NAANQKKH--.-----------.-----------------lnk....................................................
W6TGA1_9SPIR/29-143 .........................n-KGIKSRNKRDLEQQVEAQK-----T-PEEDLREKLS------------.....-.--..---DNQ.RK..............----GLDFLK...------EALSNSESEFNKFLNAD..........ESKIKDALDHIQSELAKCTG-..............DNAANQKNTF.KQVVEGALKEG.-LDNFKDQSNS------tcgqg..................................................
W6THB1_9SPIR/32-179 apttetpqanenkkynaiingfnkki-----------------------------EILRKRIK---NNSLDKIPT.....S.VQ..EHKDR-.IT..............AYEQFISWIE...KNPDKKKELDEAWTEAYNLLEQRr.......aeNAPEKTLAEYISDAIDCKENPs............cQDTKKYG-TQ.DNQINRLFGVN.SVSIFISNNSKEI----fvs....................................................
W6TFP2_9SPIR/29-142 .........................n-KGIKSRNKRDLEQQVEAQK-----T-PEEALREKLN------------.....-.--..---DSQ.KQ..............----GLDFLK...-------DALSSESELNKFLNED..........ESKIKDALDHIQSELAKCTG-..............DNAADQKTTF.KQVVKGALGGG.-LDNFKDTASS------acenn..................................................
MLPH_BORBU/30-146 ..........................AQQTKSRRKRDLTQKEVTQE-KPKSK--EELLREKLN------------.....-.--..---DDQ.KT..............----QLDWLK...-------TALTDAGEFDKFLENN..........EDKIKSALDHIKSELDKCNGK..............ENGDVQKNTF.KQVVQGALKGG.-IDGFG--ASNATTTCN.......................................................
MLPG_BORBU/25-140 ..........................TKQTKSRQKRDLTQKEATQE-KPKSKSKEDLLREKLS------------.....-.--..---DDQ.KT..............----QLDWLK...-------TALTGVGKFDKFLEND..........EGKIKSALEHIKTELDKCNGN..............---DEGKNTF.KTTVQGFFSGG.NIDNF---ADQATATCN.......................................................
W6TKF0_9SPIR/210-373 ......................eaii---------------EKTKNEVTSITEDEQKKFEILQQIFHKTNQKLKT.....T.TEyyEKEEEN.KYhagsdyhyyknmneKATEFITYLN...KSKQSQKKLANAFNTVYDLLEKKr.......kqHASDITFEQYIDNAFKCTIEKv............tCSPDKYGHHDlGSSIPDFFESI.-----------------lteclyskdhnrkrvnyl.....................................
O50929_BORBU/40-205 .................dvvkdlipk---------------------EISLTPEEAEKLESLK-VFLKDAMSVNG.....R.EE..ALKAEY.EK..............SYKEFFDWLS...KDVNRQKEFISSFDNISSIVSKAvdaskkrrptEQQSLGFKEYVCYKIKNSKGE..............----------.-----------.-----------------alslffqkvvdafgadpykkdndesvqkpvkcneeifkvikkvltesesnnelkn
MLPD_BORBU/25-138 .........................n-SQTKSRQKRDLTQKEATQE-KPKSK--EELLREKLN------------.....-.--..---DNQ.KT..............----HLDWLK...-------EALGNDGEFNKFLGYD..........ESKIKSALDHIKSELDSCTG-..............D-KVENKNTF.KQVVQEALKGG.-IDGF---ENTASSTC-k......................................................
W6TGP4_9SPIR/18-174 ..............kehsktpkktqn-----------FTDNSTTHN-ELTKIDDTNIKFNVLHKALQNTIEYLKR.....TrSN..ELQNNQ.EN..............RYNQFFEWIL...KHPNKQKELANSFTAVYNFLKDKq.......kkNANNSDLNTYINNALICQEHNsnptl....nkklpE---------.-----------.-----------------kchkqynsdstyntinfdliayffknmi...........................
MLPA_BORBU/30-145 ..........................AQQTKSRGKRDLTQKEATPE-KPKSK--EELLREKLS------------.....-.--..---EDQ.KT..............----HLDWLK...-------EALGNDGEFDKFLGYD..........ESKIKTALDHIKSELDKCNG-..............NDADQQKTTF.KQTVQGALSGG.-IDGFG--SNNAVTTC-g......................................................
#=GR MLPA_BORBU/30-145 SS ..........................XXXXXXXXXXXXXXXXXXXX-XS--H--HHHHHHHS-------------.....-.--..---HHH.HH..............----HHHHHH...-------HHH-SHHHHHHHHTS-..........HHHHHHHHHHHHHHHHT--S-..............SSHHHHHHHH.HHHHHTTSSS-.-STT-S--TTT---TT-T......................................................
W6TH67_9SPIR/29-140 .........................n-KGIKSRNKRDLEQQVEAQK-----T-PEENLREKLS------------.....-.--..---DSQ.KQ..............----GLDFLK...-------EALSSGSDFNNFLNAE..........ESKIKEALDHIQSELAKCTG-..............ENAAQQKTTF.KQTVKGALGGG.-LDDFKSN---------vastcd.................................................
W6TG16_9SPIR/1-47 ........................ms-------------------------------------------------.....-.--..------.--..............----------...-----------NESEINKFLNED..........ESKIKEALDHIQSELAKCTGRit..........qlTK--------.-----------.-----------------kehskk.................................................
MLPJ_BORBU/30-183 ..........................AQQTKSRKKRDLSQEELPQQEKITLTSDEEKMFTSLINVFKYTIEKLNN.....E.IQ..GCMNGN.KS..............KCNDFFDWLS...EDIQKQKELAGAFTKVYNFLKS-..........KAQNETFDTYIKGAIDCKKNTpq..........dcNKNNKYGDGD.-NLIEQYFRGV.ANDMSNRNSNEEIYQYL.......................................................
W6TG38_9SPIR/29-140 .........................n-KGIKSRNKRDLEQQVEAQK-----T-PEEALREKLN------------.....-.--..---DNQ.KK..............----GLDFLK...-------DALSSESDFNNFLNED..........ESKIKDALDHIQSELAKCTG-..............DEAADKKNTF.KQVVEGALKEG.-LDNFKGQSN-------stcg...................................................
W6TWD7_9SPIR/29-140 .........................n-KGIKSRNKRDLEQQVEAQK-----T-PEEALREKLN------------.....-.--..---NNQ.RK..............----GLDFLK...-------EALSSESDFNNFLNAD..........ESKIKDALDHIQSELAKCTG-..............DEAADKKNTF.KQVVEGALKEG.-LDNFKGQSN-------stcg...................................................
W6TGZ2_9SPIR/18-173 .............sctdkvkeptsaq-------------------------QANDNKNFNTIINGFNTAIEILRK.....N.VK..KSKKGE.IQlqnpdn..yktvidRYEQFISWIE...KNPDKKKELDTDLTEAYNWLEKRr.......seNAYEKTLAEYINNALDCKNSL..............CKDLKKYGTY.TNQIDTFFGIN.SHEIFFAHN--------npedqfvkf..............................................
MLPI_BORBU/25-140 ..........................TSQTKSRQKRDLTQKEATQE-KPKSK--EDLLREKLS------------.....-.--..---EDQ.KT..............----HLDWLK...-------TALTGAGEFDKFLGYD..........EDKIKGALNHIKSELDKCTG-..............DNSEQQKSTF.KEVVKGALGGG.-IDSF---ATSASSTC-qa.....................................................
W6TEQ3_9SPIR/151-277 ......keaydsncleytkivdnygl-------------------------------------------------.....-.--..------.--..............----FVMWVN...DDPSYQKELVGAFTKTYNFLIGKk.......niHASNEDIDLYIKNAIQWYEKQfmflrdksnrikdlSRGGIYGENS.KNYIYDFFSTV.IR---------------agfrdidfskteakqsl......................................
W6TXH2_9SPIR/39-195 ...................kpsvsim------------------------STEEKNKL-NALIYGLNMTIKRYDNiykakD.TQ..TVANDI.KR..............-YNKFHNWIFndpAQIQKQKELIDAFSYAYDFIDDKrk.....klaSHKYKSTEQYIKDSFHFFHNEeyrks....htydpSWYGRTKNDF.ANYINVYFLGI.IMQSISRTNEH------atseeif................................................
#=GC SS_cons ..........................XXXXXXXXXXXXXXXXXXXX-XS--H--HHHHHHHS-------------.....-.--..---HHH.HH..............----HHHHHH...-------HHH-SHHHHHHHHTS-..........HHHHHHHHHHHHHHHHT--S-..............SSHHHHHHHH.HHHHHTTSSS-.-STT-S--TTT---TT-T......................................................
#=GC seq_cons ..............................ppR.pRslpQp.tspp.....p..E-hLhEcLp..........................-sQ.Kp..................hlDWLc..........-hlsuhuchspFLptc..........-uKhKssh-aIpspLspssG...............spstppKsTh.cphlpthhtts..hp.h...tp..............................................................
//
