GenomeNet

Database: Pfam
Entry: OATP
LinkDB: OATP
Original site: OATP 
#=GF ID   OATP
#=GF AC   PF03137.22
#=GF DE   Organic Anion Transporter Polypeptide (OATP) family
#=GF PI   OATP_C;
#=GF AU   Mifsud W;0000-0002-9805-6461
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_626 (release 6.5)
#=GF GA   25.80 25.80;
#=GF TC   25.80 25.80;
#=GF NC   25.70 25.70;
#=GF BM   hmmbuild  --handHMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Organo_anion_transporter_family
#=GF CL   CL0015
#=GF NE   PF07648;
#=GF NL   Q9W269.1/546-588
#=GF RN   [1]
#=GF RM   10873595
#=GF RT   Molecular identification and characterization of novel members
#=GF RT   of the human organic anion transporter (OATP) family. 
#=GF RA   Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, Tsuji A; 
#=GF RL   Biochem Biophys Res Commun 2000;273:251-260.
#=GF DR   INTERPRO; IPR004156;
#=GF DR   TC; 2.A.60;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of several eukaryotic
#=GF CC   Organic-Anion-Transporting Polypeptides (OATPs). Several have
#=GF CC   been identified mostly in human and rat. Different OATPs vary in
#=GF CC   tissue distribution and substrate specificity. Since the
#=GF CC   numbering of different OATPs in particular species was based
#=GF CC   originally on the order of discovery, similarly numbered OATPs
#=GF CC   in humans and rats did not necessarily correspond in function,
#=GF CC   tissue distribution and substrate specificity (in spite of the
#=GF CC   name, some OATPs also transport organic cations and neutral
#=GF CC   molecules). Thus, Tamai et al. [1] initiated the current scheme
#=GF CC   of using digits for rat OATPs and letters for human ones.
#=GF CC   Prostaglandin transporter (PGT) proteins (e.g. Swiss:Q92959) are
#=GF CC   also considered to be OATP family members. In addition, the
#=GF CC   methotrexate transporter OATK (Swiss:P70502) is closely related
#=GF CC   to OATPs. This family also includes several predicted proteins
#=GF CC   from Caenorhabditis elegans and Drosophila melanogaster. This
#=GF CC   similarity was not previously noted.  Note: Members of this
#=GF CC   family are described (in the Swiss-Prot database) as belonging
#=GF CC   to the SLC21 family of transporters.
#=GF SQ   5946
#=GS A0A091GHN2_9AVES/2-595      AC A0A091GHN2.1
#=GS A0A182YLQ7_ANOST/125-787    AC A0A182YLQ7.1
#=GS A0A4W2EKK3_BOBOX/412-677    AC A0A4W2EKK3.1
#=GS A0A671FWE5_RHIFE/165-589    AC A0A671FWE5.1
#=GS A0A2K5WY12_MACFA/108-206    AC A0A2K5WY12.1
#=GS A0A060XMP3_ONCMY/3-252      AC A0A060XMP3.1
#=GS A0A2P8YYS0_BLAGE/82-559     AC A0A2P8YYS0.1
#=GS A0A2K5N0T3_CERAT/1-574      AC A0A2K5N0T3.1
#=GS M3VVR6_FELCA/44-176         AC M3VVR6.3
#=GS A0A673BMJ2_9TELE/9-539      AC A0A673BMJ2.1
#=GS A0A484GL50_SOUCH/33-602     AC A0A484GL50.1
#=GS A0A2K6TFA4_SAIBB/29-586     AC A0A2K6TFA4.1
#=GS A0A4W2CI27_BOBOX/50-230     AC A0A4W2CI27.1
#=GS L5KIZ8_PTEAL/130-433        AC L5KIZ8.1
#=GS H2L5X8_ORYLA/21-580         AC H2L5X8.2
#=GS A0A671EG69_RHIFE/209-569    AC A0A671EG69.1
#=GS U4TZA6_DENPD/91-683         AC U4TZA6.1
#=GS T1ERC0_HELRO/32-215         AC T1ERC0.1
#=GS A0A668AI40_9TELE/16-553     AC A0A668AI40.1
#=GS V4AN07_LOTGI/1-265          AC V4AN07.1
#=GS A0A6A4KB16_APOLU/119-727    AC A0A6A4KB16.1
#=GS H2LXW0_ORYLA/18-382         AC H2LXW0.2
#=GS A0A158QEH2_HYMDI/544-723    AC A0A158QEH2.1
#=GS A0A0V1DGA4_TRIBR/9-680      AC A0A0V1DGA4.1
#=GS A0A556TXF3_BAGYA/186-563    AC A0A556TXF3.1
#=GS A0A091KJK7_9GRUI/1-61       AC A0A091KJK7.1
#=GS A0A4W3GHN5_CALMI/196-624    AC A0A4W3GHN5.1
#=GS S4RLL1_PETMA/1-220          AC S4RLL1.1
#=GS A0A674E665_SALTR/278-343    AC A0A674E665.1
#=GS A0A0D9RRP2_CHLSB/110-668    AC A0A0D9RRP2.1
#=GS A0A1D3CXG9_9EIME/175-675    AC A0A1D3CXG9.1
#=GS A0A5J5N028_MUNRE/8-581      AC A0A5J5N028.1
#=GS A0A0C2J210_THEKT/1-454      AC A0A0C2J210.1
#=GS A0A182EQS4_ONCOC/80-335     AC A0A182EQS4.1
#=GS A0A084WME8_ANOSI/105-704    AC A0A084WME8.1
#=GS M7AQC5_CHEMY/29-250         AC M7AQC5.1
#=GS A0A1S3LG82_SALSA/124-705    AC A0A1S3LG82.1
#=GS F7D880_XENTR/43-601         AC F7D880.3
#=GS A0A0V1N5Q5_9BILA/836-1002   AC A0A0V1N5Q5.1
#=GS H3B9X4_LATCH/84-266         AC H3B9X4.1
#=GS A0A2K5VDE1_MACFA/128-526    AC A0A2K5VDE1.1
#=GS A0A3Q4HBX6_NEOBR/39-592     AC A0A3Q4HBX6.1
#=GS A0A498NZN8_LABRO/1-74       AC A0A498NZN8.1
#=GS A0A672HNX4_SALFA/201-492    AC A0A672HNX4.1
#=GS A0A2I3H1X2_NOMLE/107-204    AC A0A2I3H1X2.1
#=GS A0A2T7P0X3_POMCA/1-36       AC A0A2T7P0X3.1
#=GS H0ZMI1_TAEGU/13-621         AC H0ZMI1.2
#=GS A0A158NWN1_ATTCE/1-611      AC A0A158NWN1.1
#=GS A0A232FIW2_9HYME/76-645     AC A0A232FIW2.1
#=GS A0A671Y099_SPAAU/9-584      AC A0A671Y099.1
#=GS A8WRK7_CAEBR/18-596         AC A8WRK7.2
#=GS A0A3Q7TML2_VULVU/1-546      AC A0A3Q7TML2.1
#=GS A0A2I3MNY0_PAPAN/30-420     AC A0A2I3MNY0.1
#=GS A0A2U4BL27_TURTR/21-596     AC A0A2U4BL27.2
#=GS A0A369S516_9METZ/67-653     AC A0A369S516.1
#=GS A0A1S3MZ27_SALSA/51-649     AC A0A1S3MZ27.1
#=GS A0A2I2URI5_FELCA/132-422    AC A0A2I2URI5.1
#=GS G3I9N8_CRIGR/197-241        AC G3I9N8.1
#=GS A0A4E0R5T1_FASHE/265-1059   AC A0A4E0R5T1.1
#=GS A0A2I3LQ34_PAPAN/1-574      AC A0A2I3LQ34.1
#=GS A7S2I0_NEMVE/135-603        AC A7S2I0.1
#=GS A0A2Y9FPD9_PHYMC/44-638     AC A0A2Y9FPD9.1
#=GS A0A151M960_ALLMI/39-620     AC A0A151M960.1
#=GS A0A2G8KTQ6_STIJA/89-653     AC A0A2G8KTQ6.1
#=GS A0A0P7V5W2_SCLFO/128-700    AC A0A0P7V5W2.1
#=GS G3WWQ7_SARHA/43-640         AC G3WWQ7.1
#=GS E4XJT8_OIKDI/8-366          AC E4XJT8.1
#=GS A0A452FDL2_CAPHI/139-698    AC A0A452FDL2.1
#=GS U6MKX5_9EIME/1026-1258      AC U6MKX5.1
#=GS A0A3P8S6F5_AMPPE/18-578     AC A0A3P8S6F5.1
#=GS A0A6G0UVE9_9BILA/9-613      AC A0A6G0UVE9.1
#=GS A0A2I3SX16_PANTR/128-526    AC A0A2I3SX16.1
#=GS A0A3Q3AWI1_KRYMA/34-621     AC A0A3Q3AWI1.1
#=GS H2PQI7_PONAB/129-734        AC H2PQI7.1
#=GS A0A1D1VNL1_RAMVA/1-70       AC A0A1D1VNL1.1
#=GS A0A5C6PDQ3_9TELE/7-401      AC A0A5C6PDQ3.1
#=GS A0A060XD73_ONCMY/159-474    AC A0A060XD73.1
#=GS A0A0M3K4E1_ANISI/9-651      AC A0A0M3K4E1.1
#=GS V8NJ27_OPHHA/112-618        AC V8NJ27.1
#=GS A0A0G2K9W9_RAT/88-650       AC A0A0G2K9W9.1
#=GS B4LRE4_DROVI/89-673         AC B4LRE4.2
#=GS A0A1S3KRY7_SALSA/54-639     AC A0A1S3KRY7.1
#=GS A0A0N4TQL8_BRUPA/24-688     AC A0A0N4TQL8.1
#=GS A0A2A2LPN3_9BILA/29-274     AC A0A2A2LPN3.1
#=GS A0A4X2LAZ0_VOMUR/107-531    AC A0A4X2LAZ0.1
#=GS A0A2G9R3W9_LITCT/185-386    AC A0A2G9R3W9.1
#=GS A0A673ZWX0_SALTR/154-758    AC A0A673ZWX0.1
#=GS A0A452RQG3_URSAM/44-624     AC A0A452RQG3.1
#=GS A0A3P7J3D4_STRVU/25-269     AC A0A3P7J3D4.1
#=GS E2BWD3_HARSA/56-269         AC E2BWD3.1
#=GS A0A3Q3L876_9TELE/18-611     AC A0A3Q3L876.1
#=GS A0A3Q3SHC0_9TELE/118-703    AC A0A3Q3SHC0.1
#=GS A0A2K5CTU9_AOTNA/198-408    AC A0A2K5CTU9.1
#=GS A0A2U9BHW5_SCOMX/144-753    AC A0A2U9BHW5.1
#=GS A0A026X1N1_OOCBI/74-674     AC A0A026X1N1.1
#=GS F6TIF0_CIOIN/25-583         AC F6TIF0.2
#=GS A0A287ASP2_PIG/41-622       AC A0A287ASP2.1
#=GS A0A498LHE8_LABRO/435-526    AC A0A498LHE8.1
#=GS G3UKL3_LOXAF/1-260          AC G3UKL3.1
#=GS A0A0V1DHZ5_TRIBR/15-209     AC A0A0V1DHZ5.1
#=GS A0A3M0JAH5_HIRRU/436-586    AC A0A3M0JAH5.1
#=GS G3NAV0_GASAC/31-610         AC G3NAV0.1
#=GS A0A5E4CLT1_MARMO/2-193      AC A0A5E4CLT1.1
#=GS H3APF3_LATCH/2-256          AC H3APF3.1
#=GS A0A4W2H9K6_BOBOX/31-624     AC A0A4W2H9K6.1
#=GS A0A3Q0CPR7_MESAU/5-561      AC A0A3Q0CPR7.1
#=GS A0A4W6D334_LATCA/41-624     AC A0A4W6D334.1
#=GS A0A4Z2GZT9_9TELE/4-170      AC A0A4Z2GZT9.1
#=GS A0A0L7LTU7_9NEOP/103-277    AC A0A0L7LTU7.1
#=GS A0A4V6A0P9_STECR/7-194      AC A0A4V6A0P9.1
#=GS A0A2Y9NH83_DELLE/21-596     AC A0A2Y9NH83.1
#=GS Q5RIX3_DANRE/48-631         AC Q5RIX3.2
#=GS A0A3Q2GXM8_HORSE/33-600     AC A0A3Q2GXM8.2
#=GS SO4A1_HUMAN/104-663         AC Q96BD0.2
#=GS A0A267DBH7_9PLAT/121-725    AC A0A267DBH7.1
#=GS A0A5E4CZU4_MARMO/132-313    AC A0A5E4CZU4.1
#=GS A0A1U7SNW4_ALLSI/21-606     AC A0A1U7SNW4.1
#=GS A0A093IIJ4_EURHL/3-593      AC A0A093IIJ4.1
#=GS A0A3Q2DK96_CYPVA/35-614     AC A0A3Q2DK96.1
#=GS A0A1A6FVN0_NEOLE/48-204     AC A0A1A6FVN0.1
#=GS U3K733_FICAL/1-558          AC U3K733.1
#=GS H2Y4M6_CIOSA/9-565          AC H2Y4M6.1
#=GS A0A2U9BWI7_SCOMX/33-627     AC A0A2U9BWI7.1
#=GS L9KDK7_TUPCH/49-179         AC L9KDK7.1
#=GS A0A482WG61_LAOST/77-662     AC A0A482WG61.1
#=GS A0A093FAE3_TYTAL/1-63       AC A0A093FAE3.1
#=GS B4N049_DROWI/76-655         AC B4N049.2
#=GS A0A672HNV0_SALFA/18-371     AC A0A672HNV0.1
#=GS A0A210Q3Z8_MIZYE/43-602     AC A0A210Q3Z8.1
#=GS A0A2I4BV72_9TELE/1-228      AC A0A2I4BV72.1
#=GS A0A668A1N4_9TELE/271-571    AC A0A668A1N4.1
#=GS A0A091UB09_PHORB/241-533    AC A0A091UB09.1
#=GS A0A2R9AV05_PANPA/32-601     AC A0A2R9AV05.1
#=GS T1HZ09_RHOPR/117-169        AC T1HZ09.1
#=GS A0A183NTQ8_9TREM/737-845    AC A0A183NTQ8.1
#=GS A0A643C7J4_BALPH/185-511    AC A0A643C7J4.1
#=GS F1MSP4_BOVIN/127-732        AC F1MSP4.2
#=GS B4KJ36_DROMO/34-688         AC B4KJ36.1
#=GS A0A2R9BY32_PANPA/104-663    AC A0A2R9BY32.1
#=GS A0A3Q1FND1_9TELE/33-629     AC A0A3Q1FND1.1
#=GS A0A154P055_DUFNO/49-615     AC A0A154P055.1
#=GS A0A194PWF4_PAPXU/747-1066   AC A0A194PWF4.1
#=GS A0A2K5V0W9_MACFA/44-171     AC A0A2K5V0W9.1
#=GS A0A060WS28_ONCMY/726-1322   AC A0A060WS28.1
#=GS B4I826_DROSE/112-731        AC B4I826.1
#=GS A0A094KGN4_ANTCR/1-86       AC A0A094KGN4.1
#=GS A0A182YT28_ANOST/1-112      AC A0A182YT28.1
#=GS A0A3Q1C6R7_AMPOC/35-579     AC A0A3Q1C6R7.1
#=GS A0A2K6BHE3_MACNE/108-206    AC A0A2K6BHE3.1
#=GS I3JU43_ORENI/18-613         AC I3JU43.1
#=GS A0A4E0RIW2_FASHE/44-589     AC A0A4E0RIW2.1
#=GS A0A5C6P4C7_9TELE/143-329    AC A0A5C6P4C7.1
#=GS H3DMV0_TETNG/12-567         AC H3DMV0.1
#=GS A0A452F8R0_CAPHI/45-616     AC A0A452F8R0.1
#=GS G3NKK4_GASAC/20-584         AC G3NKK4.1
#=GS A0A672TJJ2_STRHB/16-594     AC A0A672TJJ2.1
#=GS A0A1U7SLN0_CARSF/1-564      AC A0A1U7SLN0.2
#=GS A0A2K5J1T6_COLAP/21-597     AC A0A2K5J1T6.1
#=GS A0A2I3TJ22_PANTR/129-681    AC A0A2I3TJ22.1
#=GS A0A2G9TDG8_TELCI/49-111     AC A0A2G9TDG8.1
#=GS A0A5F5PN05_HORSE/132-684    AC A0A5F5PN05.1
#=GS L5LBX1_MYODS/67-212         AC L5LBX1.1
#=GS A0A6Q2Z833_ESOLU/18-612     AC A0A6Q2Z833.1
#=GS A0A2K5RJR1_CEBCA/29-621     AC A0A2K5RJR1.1
#=GS A0A087Y172_POEFO/161-767    AC A0A087Y172.2
#=GS C9JSB7_HUMAN/19-71          AC C9JSB7.1
#=GS A0A2K5W5F2_MACFA/1-574      AC A0A2K5W5F2.1
#=GS H2ZCF2_CIOSA/1-466          AC H2ZCF2.1
#=GS I3K284_ORENI/52-610         AC I3K284.2
#=GS W4XPJ4_STRPU/1-108          AC W4XPJ4.1
#=GS A0A6I8PW93_XENTR/37-618     AC A0A6I8PW93.1
#=GS A0A5S6P9Y1_BRUMA/9-706      AC A0A5S6P9Y1.1
#=GS A0A5N3XLC4_MUNRE/27-95      AC A0A5N3XLC4.1
#=GS A0A099ZL39_TINGU/1-156      AC A0A099ZL39.1
#=GS G1T960_RABIT/29-621         AC G1T960.2
#=GS A0A0V1A2J7_9BILA/65-641     AC A0A0V1A2J7.1
#=GS A0A0M8ZWE7_9HYME/23-631     AC A0A0M8ZWE7.1
#=GS A0A556U301_BAGYA/28-614     AC A0A556U301.1
#=GS A0A368GZF5_ANCCA/47-615     AC A0A368GZF5.1
#=GS A0A091E2F0_FUKDA/261-303    AC A0A091E2F0.1
#=GS A0A4D9E6Q3_9SAUR/173-758    AC A0A4D9E6Q3.1
#=GS L7TAY6_MACFA/29-621         AC L7TAY6.1
#=GS A0A2G8JI52_STIJA/36-474     AC A0A2G8JI52.1
#=GS A0A665UKQ4_ECHNA/19-572     AC A0A665UKQ4.1
#=GS A0A2K6D4G7_MACNE/106-657    AC A0A2K6D4G7.1
#=GS A0A3Q3F263_9LABR/12-522     AC A0A3Q3F263.1
#=GS A0A384B5F9_BALAS/21-596     AC A0A384B5F9.1
#=GS A0A337S8J0_FELCA/103-662    AC A0A337S8J0.2
#=GS A0A0V0TQL8_9BILA/2277-2881  AC A0A0V0TQL8.1
#=GS A0A2K5U5Q8_MACFA/50-647     AC A0A2K5U5Q8.1
#=GS A0A3M0JP17_HIRRU/811-871    AC A0A3M0JP17.1
#=GS A0A1V4JF16_PATFA/21-605     AC A0A1V4JF16.1
#=GS M7AQC5_CHEMY/244-286        AC M7AQC5.1
#=GS A0A2K6MQU5_RHIBE/298-536    AC A0A2K6MQU5.1
#=GS B4I824_DROSE/1-382          AC B4I824.1
#=GS A0A0R3UP33_9CEST/52-368     AC A0A0R3UP33.1
#=GS A0A2I3LFK0_PAPAN/207-412    AC A0A2I3LFK0.1
#=GS A0A3P9NMT5_POERE/18-374     AC A0A3P9NMT5.1
#=GS B3MKU7_DROAN/71-659         AC B3MKU7.1
#=GS A0A2K5L5L3_CERAT/1-506      AC A0A2K5L5L3.1
#=GS A0A2K5RS96_CEBCA/41-622     AC A0A2K5RS96.1
#=GS A0A158NTA5_ATTCE/74-672     AC A0A158NTA5.1
#=GS A0A482X9Z0_LAOST/199-459    AC A0A482X9Z0.1
#=GS A0A3Q7SB94_VULVU/41-622     AC A0A3Q7SB94.1
#=GS A0A1U7Q3V9_MESAU/132-737    AC A0A1U7Q3V9.1
#=GS H3AKT7_LATCH/11-169         AC H3AKT7.1
#=GS A0A2I4BB77_9TELE/120-705    AC A0A2I4BB77.1
#=GS A0A3P8XYA5_ESOLU/103-666    AC A0A3P8XYA5.2
#=GS A0A2U3Z4S1_LEPWE/2-299      AC A0A2U3Z4S1.1
#=GS A0A0V1H6P5_9BILA/82-712     AC A0A0V1H6P5.1
#=GS G1RFQ6_NOMLE/104-650        AC G1RFQ6.3
#=GS A0A5F9D1K8_RABIT/413-491    AC A0A5F9D1K8.1
#=GS A0A2K5IG62_COLAP/95-654     AC A0A2K5IG62.1
#=GS A0A673SRH2_SURSU/95-633     AC A0A673SRH2.1
#=GS A0A4U1ECY1_MONMO/48-633     AC A0A4U1ECY1.1
#=GS A0A158PLF7_ANGCS/1-238      AC A0A158PLF7.1
#=GS F1R5Q0_DANRE/1-313          AC F1R5Q0.1
#=GS A0A2R9AUQ4_PANPA/32-132     AC A0A2R9AUQ4.1
#=GS A0A672I3Y1_SALFA/351-521    AC A0A672I3Y1.1
#=GS A0A1J1IFS3_9DIPT/101-705    AC A0A1J1IFS3.1
#=GS A0A0V0TRS0_9BILA/31-623     AC A0A0V0TRS0.1
#=GS A0A3Q1B3V2_AMPOC/112-458    AC A0A3Q1B3V2.1
#=GS A0A099Z8G2_TINGU/13-376     AC A0A099Z8G2.1
#=GS A0A402FTU9_9SAUR/486-551    AC A0A402FTU9.1
#=GS A0A091SLL6_NESNO/3-593      AC A0A091SLL6.1
#=GS A0A4Z2FSU0_9TELE/38-78      AC A0A4Z2FSU0.1
#=GS A0A3S3QDE8_9ACAR/30-576     AC A0A3S3QDE8.1
#=GS T1ERC4_HELRO/4-402          AC T1ERC4.1
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