GenomeNet

Database: Pfam
Entry: PRD_Mga
LinkDB: PRD_Mga
Original site: PRD_Mga 
#=GF ID   PRD_Mga
#=GF AC   PF08270.14
#=GF DE   M protein trans-acting positive regulator (MGA) PRD domain
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_5126 (release 7.7)
#=GF GA   23.00 23.00;
#=GF TC   24.10 23.00;
#=GF NC   22.20 22.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0166
#=GF RN   [1]
#=GF RM   11952907
#=GF RT   Two DNA-binding domains of Mga are required for virulence gene
#=GF RT   activation in the group A streptococcus. 
#=GF RA   McIver KS, Myles RL; 
#=GF RL   Mol Microbiol 2002;43:1591-1601.
#=GF DR   INTERPRO; IPR013236;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Mga is a DNA-binding protein that activates the expression of
#=GF CC   several important virulence genes in group A streptococcus in
#=GF CC   response to changing environmental conditions [1]. This
#=GF CC   corresponds to the PRD like region.
#=GF SQ   52
#=GS Q99XU9_STRP1/179-397      AC Q99XU9.1
#=GS K1LPL9_9LACT/172-390      AC K1LPL9.1
#=GS H3NE90_9LACT/179-400      AC H3NE90.1
#=GS A0A3L8GIT3_STRIN/177-381  AC A0A3L8GIT3.1
#=GS B1P5D6_STRIN/177-393      AC B1P5D6.1
#=GS A0A0C2HPI0_9STAP/173-387  AC A0A0C2HPI0.1
#=GS A0A4R9BZX7_9FIRM/171-391  AC A0A4R9BZX7.1
#=GS A0A0F2CGM5_STRCR/1-74     AC A0A0F2CGM5.1
#=GS D0BJK3_9LACT/173-391      AC D0BJK3.1
#=GS J0UWS9_STREE/173-391      AC J0UWS9.1
#=GS K8E1E3_CARML/172-386      AC K8E1E3.1
#=GS Q9A1S4_STRP1/172-382      AC Q9A1S4.1
#=GS H3NIL0_9LACT/173-388      AC H3NIL0.1
#=GS A0A347WJL7_9LACT/172-390  AC A0A347WJL7.1
#=GS A0A429ZHR0_9ENTE/177-387  AC A0A429ZHR0.1
#=GS W1Q4A6_ABIDE/132-350      AC W1Q4A6.1
#=GS A0A4R9C3B8_9FIRM/179-396  AC A0A4R9C3B8.1
#=GS A8AZ88_STRGC/173-392      AC A8AZ88.1
#=GS A0A0U3MC74_9LACT/177-384  AC A0A0U3MC74.1
#=GS A5M648_STREE/173-392      AC A5M648.1
#=GS A0A0X8FBX0_9LACT/173-394  AC A0A0X8FBX0.1
#=GS A0A662Z1T8_9STAP/175-391  AC A0A662Z1T8.1
#=GS C8NG86_9LACT/173-392      AC C8NG86.1
#=GS G5JZP2_9STRE/178-374      AC G5JZP2.1
#=GS A0A6I2GF92_9LACT/173-390  AC A0A6I2GF92.1
#=GS A0A1M4VE17_9LACT/172-389  AC A0A1M4VE17.1
#=GS A0A6G8AMQ0_9ENTE/175-391  AC A0A6G8AMQ0.1
#=GS A0A347WJV4_9LACT/173-392  AC A0A347WJV4.1
#=GS U5SA20_9LACT/173-392      AC U5SA20.1
#=GS W7CLY3_9LIST/180-385      AC W7CLY3.1
#=GS A0A347WNV7_9LACT/157-348  AC A0A347WNV7.1
#=GS H3NI02_9LACT/175-390      AC H3NI02.1
#=GS A0A347WJT6_9LACT/175-392  AC A0A347WJT6.1
#=GS F9PZN6_9STRE/174-392      AC F9PZN6.1
#=GS Q8DP24_STRR6/181-399      AC Q8DP24.1
#=GS A0A1D2LU82_BROTH/180-381  AC A0A1D2LU82.1
#=GS J1NWF4_STREE/173-365      AC J1NWF4.1
#=GS Q8DYW7_STRA5/169-385      AC Q8DYW7.1
#=GS F9HJB6_9STRE/173-392      AC F9HJB6.1
#=GS F3AN62_9FIRM/2-199        AC F3AN62.1
#=GS A0A1H9AUM2_9LACT/173-393  AC A0A1H9AUM2.1
#=GS A0A0X8FM36_9LACT/173-363  AC A0A0X8FM36.1
#=GS A0A4R9BZY2_9FIRM/176-392  AC A0A4R9BZY2.1
#=GS H3NDN7_9LACT/175-400      AC H3NDN7.1
#=GS B9DT24_STRU0/177-394      AC B9DT24.1
#=GS E1M6G3_9STRE/173-390      AC E1M6G3.1
#=GS S0KQC2_9ENTE/175-392      AC S0KQC2.1
#=GS Q8DNN5_STRR6/192-411      AC Q8DNN5.1
#=GS A0A2N6SQ50_9LACT/19-238   AC A0A2N6SQ50.1
#=GS A0A1X7KM69_9BACL/173-359  AC A0A1X7KM69.1
#=GS A3CQR4_STRSV/173-392      AC A3CQR4.1
#=GS A5M974_STREE/173-391      AC A5M974.1
Q99XU9_STRP1/179-397                 ........................lknce------RLL...SLMIKEVDVRVNFTLFQ.HLKIL...SSVNLIRYYKGHSA..V...YDNK..KTS.Q.RFS.QLIQS.S...LEFQ.DLSRLFHLKFGLYLDETTIAEMFSNHVNDQ..LEIG--.YAFDS.IK.QD.SP..T-.GC.RKVTNw.vHLLDEL..E..IRLNLSVTNKYEVAVILHNT...TVLKE.EDITA.NYLFFDYKKSYLNFYKQEHPHLYKAFV...AGV.EKLMRSEK..EP..I..STELTNQLIYAFFIT----wensf................................................
K1LPL9_9LACT/172-390                 .........................dida----LKEFL...ISSYSIAGAQLNYPTLR.FLLFS...LSVNIVRLRQGHRI..F...VETN..AF-.D.IVY.QEFLK.M...PDQV.DRMQELAQQLGFELTLNNIKQLFIAYAKEA..FELP-S.IKETI.NE.TAiES..VR.QS.TEYLA...QIIHQL..S..DKYHVPIEDVAELAGYLHNT...AHLFK.WETET.FNILYPYLPNFIDRAYYYIGDFVTEAQ...QSL.HDYIEAME..LD..S..SEMMHNLLVYDLITHWPNL.....................................................
H3NE90_9LACT/179-400                 .................lekslldlislm---------...-------DITVEFMTFA.SFKFL...TYVGLRRYKQGNLV..NsdtLNTA..FYL.D.HLY.QSLNYdS...DKIK.QFKQHTEKIFGIPYSDELIGQIFYVYVQNN..YAIN--.-YDHL.IQ.MN.QH..DL.KS.TQLQLdigGMLYRL..S..HEFKIDLPNKFDLLLEIHNS...IHLFN.IDLGS.NYLYVRRNHYACKHLQQLIPEFYERAEgllREL.VSSLEIKH..L-..D..DPNYMEYLMYILLINWH--dl...................................................
A0A3L8GIT3_STRIN/177-381             ..........eedlvdqlleksplgqlae---------...----------QDFSLYH.HLKIL...TAINLLRLQKGYRT..-...---G..RFF.D.KSL.DWFLG.Q...D---.--FAELENTLGLTLSAETLSEIFGDYLQEG..-WLFEE.T--DI.-E.EA.SQ..N-.-K.LTVAL...EALGHL..E..ETFGLAITNQKQVAAMFHNA...LLLGP.WDQHQ.AFLIYDYRQDYLDYFKSDYPKLYQEIE...KRL.KTVFEAYC..HP..F..SDKDFEHLAYILLISWDNL.....................................................
B1P5D6_STRIN/177-393                 .............................SESALEDLI...HLSAKQLDAPIDYSLLH.HLKIM...AGVHLVRFSQGYRV..N...-DVY..PLA.Q.DLC.HQLED.E...SAFT.DLHDKFETDFLEPLNCLALSEMFSAFFLED..VMVN--.-FQKIpLA.DE.DN..QK.VD.FHDWS...QLMLTI..E..KGLPLEIANKDEICRHLHNA...TILGD.YDIYE.NFLIYDYRKPFLDYFKSNYPDLWQSLC...DSI.EATYDKKG..VD..M..QDKDLNHMLYVLLINWDNL.....................................................
A0A0C2HPI0_9STAP/173-387             ...........................de--RAFSDFL...ECVIEESGVYMDFAIFR.YVKIV...SAVNFIRYSRGHLV..D...HRSD..MD-.D.IYS.RLMKD.A...HRFE.AAE----KRLGIRLTRSAFEQIFTAFVQPH..FHYTYT.SLAAS.AD.HD.DY..TA.AS.IDALN...RLMDQL..S..IDNDIPCPDRRPIILNMHNT...ALLEK.HDIYL.RPILSDRKQAFMKRLEHEYPDFCRQLH...EAV.IEYRRVLG..RS..T..DTFILNQLIYTWFVN----wegl.................................................
A0A4R9BZX7_9FIRM/171-391             ...............keierssfhnmiie---------...--FYNINNAKFVYSFLE.IMSLI...CAVNFTRIKNKGFImnN...IDKN..NI-.-.-NL.NSLQN.Y...INSN.PFKE-FFNKFNIVLNEDNLIELFYNYLNKD..FI-F--.SFKEM.IE.KS.KY..VNlIS.SSLLKi.lSETDRI..R..KKFKLNLENLDELIIRIHNG...AILYN.TNTNI.NYIAYNRNDFYVTQIKQVFPKFTKDVE...LFI.QDLLIEIK..GV..A..KPFEINHLTYILISTWN--dl...................................................
A0A0F2CGM5_STRCR/1-74                ............................m---------...-----------------.-----...--------------..-...----..---.-.---.-----.-...----.------------------------------..------.-----.--.--.--..--.--.-----...------..-..-----------------HNT...AHLHR.QELST.EFILFDQKGNTIKNFQNIFPQFVSDIK...KGI.EHYLETLG..ID..N..NSMKVNHLSYTFITHSKHL.....................................................
D0BJK3_9LACT/173-391                 ............................n-EEDLDEFA...KYFYTPTNYPMGFAIFH.MYKWM...VMIGIYRVKNKHFV..P...IPDN..FF-.D.EVF.PPFAQ.L...PDIE.EKLVYFSEKFQISMTPEVLAQIFISFIQDT..IFLSPE.EFYAS.LE.ED.EY..AK.NS.CRLLD...EMLLKL..E..FKLNIHFNNRNDLIWYMHNT...VHLER.QETFT.DPLLFNQKQRTMNNFQKHFSSAFEIVK...SEI.MNYLKLMN..RT..H..TPEHIHHLIYTLFTHGED-m....................................................
J0UWS9_STREE/173-391                 .............................PEEDLTEFA...DFFYKITNYPMRFSIYR.MYKLM...IAISIHRVKNGHFI..D...LPNH..FY-.K.EYY.PLLKS.I...PNFQ.ETLAYFSKHFGLEMTPDTIAQIFISFLQND..IFLDPQ.EFFNS.LE.DN.SQ..AR.YS.YQLLS...QILERL..S..KQYKITFTNHDELIWHLHNT...AFFER.QEIFS.TPILFEQKALTIKKFEVYFPDFMGSAR...QEL.AQYRQAIG..QH..D..HPEQLEHLMYTILTHAENL.....................................................
K8E1E3_CARML/172-386                 ........................kelgl----INTIL...DFFLKYYQDDSGFSNKK.KLLFS...AMTALTRLKNGHVR..K...IGKI..SK-.-.ENE.EIIHE.I...LSHT.NLVQSFRQLMGIELTKNMLIQLFYVFFHDD..YILS-T.NIFPE.KL.HN.PK..VE.ED.FAIID...QFLESL..S..IKLGIELQNKELLVLKI---...-YNAR.NFLFGkNYILHNKKIGFSQHIEQEYPLFSKILK...KEIkAASFSTIE..K-..E..NPSFFNEVLYELIIHWTNL.....................................................
Q9A1S4_STRP1/172-382                 ...........kntihsflshssthlkts---------...---------PWLSESFS.FYDIL...LALSWKR--HQFSV..T...IPQT..RIF.Q.QLK.KLFVY.D...SLKK.SSHDIIETYCQLNFSAGDLDYLYLIYITAN.nSFASLQ.WTPEH.IR.QY.CQ..LF.EE.NDTFR...LLLNPI..I..TLLPNLKEQKASLVKAL---...MFFSK.SFLFNlQHFIPET--------------------...---.--------..--..-..-------------------nlfvspyykgnqklytslkliveewmaklpgkrdlnhkhfhlfchyv......
H3NIL0_9LACT/173-388                 .........................dvhq----VHQVM...RLGAKAFDFHLSFDKVH.KWMTR...TAINLVRNHYGYYL..D...LEED..LL-.N.YVH.QQIQQ.S...PDWP.AFQAAYQAATHLTCTPRLLIECFYPHIHEA..FCMD--.--QPK.SK.QE.EA..NQ.NT.YQAIQ...DFLAGF..T..DHFKIELEDTHDLVQDLYET...IQLNQ.QNLLR.PL-FVSRRDQFIQGFRMDFPLIYDYLT...QEI.TSIANHLNlkPC..E..EDSLIHQLVYTAIIKLS--pl...................................................
A0A347WJL7_9LACT/172-390             ...........................de--RVLETFI...QYFTRELNIGMNFSYYY.FVKIL...TAISLIRTIQGFFI..E...TDNS..HI-.E.PVY.NVIKD.Q...HTFK.EMKKYIREHYDRELDIDFIGQMFISFLSPN..YFFTID.SFYLE.TR.LN.DQ..IN.SS.ITYLD...WMISRL..M..RDFDLELDNKQELIYELHNT...NVLNK.ADLNV.TPILYDQKGGFVREFSAKYPEFYEAAF...KAM.QGYRNHML..EK..P..DYYMERHLTYTLIVQWR--yl...................................................
A0A429ZHR0_9ENTE/177-387             ................fqnllltqleplg---------...--------LKLKFSEIE.LLTFM...FLTICTRVKFGMLL..S...FPND..DV-.-.KNH.PWIDL.F...LSDK.TFSLLFKKEFKRSWNAVIIEQIFYPFLKDT..FFFSIT.ELDLA.AD.LS.KD..IQ.QR.LDRIK...SLIHSL..S..TKIATPIPNKKELVLILYNY...HLF--.-FIGN.NHVLFDKRKNYVLTLSEEYPQIVSLMK...QTL.LDFQFHDH..FE..W..SEAALNEAIYLLTTNWEN-f....................................................
W1Q4A6_ABIDE/132-350                 ...........................ke--AHVDKFV...ATFIKILDRPLDFSLYY.LIKRA...TIINIKR--HHFKR..D...LPLH..KTNvS.TLF.AQALE.Q...KADQ.EFVRSLADYVGEPLGDIVLSNLLYPFLRDD..FFYTYE.DMLKA.SR.LQ.AA..IH.TS.LTQAQ...LMIEDI..R..QHFNLEINNPEVLTILFHNA...SSVEC.YEVFA.KSEIFRRRATWMSHLYEDFPDFYNYIE...KSV.IQYRQANK..LH..T..GTEIVRYLIYTIFSTWS--el...................................................
A0A4R9C3B8_9FIRM/179-396             ..kekiiklqntflksigvkkfpyidnei---------...-----------------.-MTIL...YPIHIERLKSGHCV..-...LPYL..--I.K.ENF.NTIKV.Q...EAYNcSELKNLFEEFELEFTKENIIDIFYYYLHKD..IAFSFL.DLIKK.TK.SN.TL..IN.FSiYQALE...S-TYKL..S..DKFNLKLNNPYELITYIHNA...NVFLY.DNFNS.NYIVFDKHNIYISKLQIVFPEFMKELS...KTI.KKYLLIIK..GE..V..KKCHIEYLIYTVISTWDNL.....................................................
A8AZ88_STRGC/173-392                 ...........................sv--EPLCKLL...ALVYKETAFPVNFATQR.MLKLL...LVTNLYRIKFGHFL..E...VEKN..SFN.N.QLL.ESFMQ.A...EGVE.DIIASFDSEYHISLNKEVIGQLFVSYFQKM..FFIDEE.VFLNY.AK.TD.SY..VK.KS.YQLLG...DLVDQV..S..REYNIQVDNKDNLIWHLHNT...AHLHR.QELST.EFILFDQKGNTIKNFQNIFPRFVSEVK...EGI.EHYLKALD..ME..R..NSMKVNHLSYTFITHSKHL.....................................................
A0A0U3MC74_9LACT/177-384             ........................dtaqt-------YI...ELLPKNVNTPNFSEIAQgKVALW...LVICLERIEQGYFI..D...HEYE..IF-.-.-PF.KVSKK.E...PLFD.LLQKDLSFTIPLE-DQNFMTYLY---QNKD..GPLD--.--KTY.LA.EN.SR..VV.GL.FQEIL...AFIEAL..K..KQTGYTLENQSCFITNL-IR...HYFYR.SLFKGpGHILIDRVERNGKALERNFDKFTKAVR...ETL.AASPSNNW..VE..K..MRENENDLIFTLIT-----fwtgl................................................
A5M648_STREE/173-392                 .............................SSEPLSQLL...ELVYKETSFPMNLSTHR.MLKLL...LVTNLYRIKFGHFM..E...VDKD..SFN.D.QSL.DFLMQ.A...EGIE.GVAQSFESEYNISLDEEVVCQLFVSYFQKM..FFIDES.LFMKC.VK.KD.SY..VE.KS.YHLLS...DFIDQI..S..VKYQIEMENKDNLIWHLHNT...AHLYR.QELFT.EFILFDQKGNTIRNFQNIFPKFVSDIK...KEL.SHYLETLE..VC..S..SSMMVNHLSYTFITHTKHL.....................................................
A0A0X8FBX0_9LACT/173-394             ....vnlqycelflstawkvtchqytnaw---------...---------------FQ.SGKIL...LAIGIIRTQKGHLI..Q...SKDI..PLF.K.GIY.QDLID.E...LEKN.DDLKNMEQSFNFKLNLTNAVQLFMPVLNQN..IYVDLR.NFQAE.IS.ER.PL..IQ.RS.VEYLN...QFLDTI..C..QEAHVHIEHRDRLILSLHNY...AFLTTvADIQK.DSLLIDRKADYIETMSHFYPDLYDLIV...KES.EHYFQSIG..LK..P..-------------------lpygltnfiyalytgwekl..................................
A0A662Z1T8_9STAP/175-391             ............................n-EKELESFM...YSFIKELPLDIDFAFFR.NMKFI...IAINIIRIKKGFKS..K...L---..SSN.N.DID.PFILE.V...LDKN.HTHSKFSKLINLELNLETIKDIFYGFVDEL..ISYSSN.ELIES.AT.RN.IT..IS.QS.YFQML...NIIKQL..T..TKFDLTIPNQEIVITNLHNT...VTLGQ.IEVTS.NFVSEDRIKSFLQSAKDISPHFLNEAK...YLF.TEYLEDVF..GI..K..DDVLLNTMLFNIYTHW---hgl..................................................
C8NG86_9LACT/173-392                 ...........................sp--DPLSQLL...ELVYKATSFPMNLSTHR.MLKLL...LVTNLYRIKFGHFL..E...VEKD..SFN.N.QLL.EFLMQ.E...DEME.DIVKKFETEYNISLTKEVIGQLFVSYFQKM..FFIDEK.VFLKY.TK.TD.IY..VK.KS.YHLLG...DLVDQV..S..KEYNIKVDNKDNLIWHLHNT...AHLHR.QELST.EFILFDQKGNTIKNFQNIFPRFVSDLK...EGI.LHYLQTLD..ID..S..SSMKVNHLAYTFITHSKHL.....................................................
G5JZP2_9STRE/178-374                 .......................nkknhe------RLI...SLLVEKTSLNINFALFQ.HLKIV...SGVNLIRFQKGYRI..N...EYNN..NQG.K.LLL.NALEN.S...KEMK.DLSSLFRMKFNYYITEDVLTELFSNYLDKR..LELGIS.T-KTV.AF.SR.EV..TP.SP.YILSSw.iAVLDSF..E..QKLNLSISNKYNLAVHLHAT...VILGQ.EDIGV.NFLVYDYKQNYLTLLSSQY--------...---.--------..--..-..-------------------etiyscflnlvedlydk....................................
A0A6I2GF92_9LACT/173-390             ............................d-EKALTDLL...KITLNYIKLNVGHANFI.NFKFL...TAVSLSRLRNNYRI..D...LTLE..QT-.-.NLH.ELLIH.P...FDIT.PEFYATIKQLNIHITEDVLLQLFTLYIRQD..FSLTYE.GFLNK.SQ.YN.HE..LK.RS.IEALD...QLLEEL..S..ITYNIPLVNKEEIILTVQNT...TYNEG.YLPHT.AYILYNPNEELMTEIEKFSPEFIYDLT...VKV.QHYRQLVS..KP..I..GHFTIEHLVYQICVRWKHL.....................................................
A0A1M4VE17_9LACT/172-389             ..........................den---GLDLFL...NFFIKFTHMDADFAYYN.IFKTV...SAVNLIRYKQGHFV..N...ISNI..HV-.-.NFD.EIIPD.L...TVYQ.ETFSYFEETNQVKVDNMLIQQIFTPYISEE..FSLNYE.RLIEK.TK.TQ.QK..LS.TE.VAFLD...DMLEDL..S..KTHQLSLNNKETVLLNIMNA...AYLEY.KEPRS.GYILHNHNLEFASKIESEFPFFYKNLY...QAT.KNYRQLIG..KP..L..IDDGIFFMMYTI-------fifwedl..............................................
A0A6G8AMQ0_9ENTE/175-391             .........ktaktyfyyleentditlsy---------...-------------PDKK.LLTVV...FLTHLDRIAHGFR-..-...LTDR..PYS.N.DVE.PFIVS.FldnPDNP.IDKKAFYKTFNVTLSSDVIQEIFSAFLSND..FILTPA.DFDKR.LAlKE.EP..LY.SR.VGIIQ...TFLTNL..S..NRLKIDIPNYDKLVFELYN-...--IHK.LFIGK.NYILFNRREYFAQYAKKEYPYFVSVLI...EEL.DNFK----..--..-..-------------------fdssfewdqdsfnevlytllinwqdi...........................
A0A347WJV4_9LACT/173-392             ..........................dqq---VLDNFI...NFILDSFRIDINYEEFR.YVEYV...MSVTLLRMSLGFVL..E...VDTT..NPM.M.PIFeAFIQS.N...NQNV.EAFRVLVEALGIELTATNFSHMIAKFYETP..FLNYGI.QNIVN.ME.RS.NL..LE.ET.HRLIG...DIVDIL..T..EKYELQLNNRHHLMNNVNKL...LHMSS.SNLGS.NELFFRQQESFLRKIRAINPDFYKSIY...-E-.--------..--..-..-------------------lvdnklinayqndawssdylvaiillnweni......................
U5SA20_9LACT/173-392                 .......................nqnffe------QLL...LLLARVNHIPLDFSDFK.RLKLW...TAIPFLRAQQGNYT..A...IQSS..NY-.-.--T.DMIPD.F...SKFQ.PVTGMIEKKLAITLDKAFIEQVFSIFINNH..FSFSYE.SLMEE.AK.KN.SL..VK.KN.VFYHA...DLLHNL..S..SQIGIPIPNFNHLLKEMYNIsnfAFKSK.KGQYPpPFILFDQKKLFVHSIKELFPDFIKASY...TTL.KLYEKNIH..ET..F..SESAKYEIIYTLIIQWDHL.....................................................
W7CLY3_9LIST/180-385                 ...lyemmcetvnetpamqdrlrlrywfm---------...-----------------.-----...--ASIIRINNGHHL..T...LESN..EV-.P.QEV.KQLYQ.N...EQLQ.---IAFTFLLDCEFTPTILMELLVIFADIN..YFSNTS.ALKTH.LK.QT.TT..DN.LL.ARNIY...TFLTNL..S..ENTHIPLTNIDEVALQLYNK...HYLL-.--VGP.NYIIYNRKALFAKRIREVYPFFVASVQ...QEL.SKLSSAQD..FY..Y..KDYAVNEILYTLLIHWEN-f....................................................
A0A347WNV7_9LACT/157-348             ................deqsltncltnia---------...----LALNIPLDYKKLR.YLKLA...TCVSWLRLRQGHKF..H...LGNRreRII.D.EAR.-DILG.M...PRFH.SCLRTSSIMNALSFDEDLLSQTFAIFMNQA..HLID--.--LNS.YS.DD.VF..IE.ES.RVFFQ...DKVEEL..I..ERFSLKLEDTEA--------...-----.-----.---------------------------...---.--------..--..-..-------------------yyrqivsnirlipasleartlfvdritpfneciqafnpdfyqalsamtqeyld
H3NI02_9LACT/175-390                 .............qplmlefvqipfsyie---------...--------PSQSFASFR.NFLLE...TTVNLFRIQQGYNS..Q...LSTV..DQK.KiNAC.SIILS.D...THFH.TIKQDVEQFFAIRIDTTQIYQIFFNYLHES..FALS--.-TMDL.ME.TP.DH..-H.RS.FQLLR...QMIHSL..C..DEFNITTENSRDLIIYLHNL...VHSEN.FYIGN.QPLLINRNQSFSQMARFLQPAFYDRIK...SML.DHYLAEMN..IQ..I..SENGKEFMIVCIYTQWKEL.....................................................
A0A347WJT6_9LACT/175-392             ...........................de--AFITDLL...VFLTDLLNVPMTFASMQ.MVKMN...ISVAMTRTLQGFRI..E...SNHS..KI-.Q.AMY.QIALD.M...HDFR.RFQAEFKKHYDIELNMDFLEQLFSEYTGEY..YYFNHD.DFYMA.QQ.AN.TY..VN.QS.VTYLN...LMLTNI..S..SMHRLEIPNRKELIYHLHNT...AHLDQ.FDTYV.TPILFPRKRRFVEEVESMYPAFYQDIY...RGL.VGYRDFLE..RP..V..DENMLNHLIYTLCI-----fwet.................................................
F9PZN6_9STRE/174-392                 ............................k-ETDIDNFV...SFFLKLTKFPAKYQNLY.QIKTQ...ATVDLHRMKRGYFI..Q...LSEQ..AT-.S.WLN.PIFNK.L...PKYQ.NQLLTLEKQLNITITPETLSQIFSPFAEPG..LFFTVE.EFLDA.RQ.IY.EE..VN.RS.YHAAR...DILDNL..T..RKFGVQFSNADALIWNLHNT...ALLER.REINS.ESIISKNKDYTLGKIKKFFPKFYDAAV...FEM.VRYKNIIG..QK..K..KSLALSHLIYTLFTHADSL.....................................................
Q8DP24_STRR6/181-399                 .............................PEEDLTEFA...DFFYKITNYPMRFSIYR.MYKLM...IAISIHRVKNGHFI..D...LPNH..FY-.K.EYY.PLLKS.I...PNFQ.ETLAYFSKHFGLEMTPDTIAQIFISFLQND..IFLDPQ.EFFNS.LE.DN.SQ..AR.YS.YQLLS...QILEGL..S..KQYKITFTNHDELIWHLHNT...AFFER.QEIFS.TPILFEQKALTIKKFEVYFPDFMGSAR...QEL.AQYRQAIG..QH..D..HPEQLEHLMYTILTHAENL.....................................................
A0A1D2LU82_BROTH/180-381             ............fisatksnghtvnfpqi---------...----------------E.KLRIW...IMVIIIRLQNGNHT..D...VYTP..FS-.E.DVD.LSALE.N...PLFK.N---LFKLTFKVELTDEVIFRLFYPFINEN..FAVNQE.TLTSM.VQ.KK.SE..VA.EK.VTALR...TLLDNI..A..LKMNIPQPNQNEVLLNLYNI...SIFQY.---GK.PYILYNRYQYFVDSIEKDYPEFIAVFK...EEL.SKS-NLGE..L-..-..ETHTINSFAYTIFTNWQNL.....................................................
J1NWF4_STREE/173-365                 .............................SSEPLSQLL...ELVYKETSFPMNLSTHR.MLKLL...LVTNLYRIKFGHFM..E...VDKD..SFN.D.QSL.DFLMQ.A...EGIE.GVAQSFESEYNISLDEEVVCQLFVSYFQKM..FFIDES.LFMKC.VK.KD.SY..VE.KS.YHLLS...DFIDQI..S..VKYQIEMENKDNLIWHLHNT...AHLYR.QELFT.EFILFDQKGNTIRNFQNIFPKFVSDIK...KS-.--------..--..-..-------------------flti.................................................
Q8DYW7_STRA5/169-385                 .............................SEVMIRDFIeysNFKGCDYDLKDLSEEYY.YFYIL...VNLVWKR--KEYKV..E...IPQT..ESF.N.QLK.KSILY.M...ELSK.AAQKSIAIHLGIELNEGLLDYLYLVFCISD..GPLF-S.NRDDI.NI.NE.EF..IF.AS.YKISKs.kAFKNFC..G..RLLGREFIDSQHFKDIN---...AYFLR.HFICYcYYFIPDFYFLNTSRLSYSK-DLYHLLD...KGL.ADIFNLKG..G-..-..NLTFSKHETVLLTMQLSNL.....................................................
F9HJB6_9STRE/173-392                 ...........................sp--EPLSQLL...ELVYKVTSFPMNLSTHR.MLKLL...LVTNLYRIKFGHFL..E...VEKD..SFN.N.QLL.ESFMQ.A...EEIE.DIVVSFDSEYHISLNKEVIGQLFVSYFQKM..FFIDEN.LFMSC.AK.TD.NY..VK.NS.YQLLS...DLIDQI..E..SKYNLKIDNKDNLIWHLHNT...AHLHR.QELST.EFILFDQKGNTIKNFQNIFPQFVSDIK...KGI.EHYLVTLD..IN..N..NSMKVNHLSYTFITHSKHL.....................................................
F3AN62_9FIRM/2-199                   ........................nflec---------...-----------TSAEYG.YFEYL...LILAWKR--KKYPL..T...FEKS..EEL.E.SLK.QLFVF.P...ELKK.YLQENLENKLNISFSDRDYDYIFLVYCCTNscVFADKW.KREDI.EL.VH.KI..IF.AN.GKV-K...HLIKKF..E..NKFCLDVTQSHAFKSSI---...IYFYK.KCFFNlHCIIPDKHFYLDSKKDSSK-LM---VR...QCV.SE------..--..-..-------------------midtwkkenhipypvdaghlqylslqif.........................
A0A1H9AUM2_9LACT/173-393             ...........................de--HFLEEFL...IFLSHHCQIKLTFADLR.ALKLS...TAVYLYRHFDQHIAnwH...IDQD..KS-.D.DYY.HSLMM.D...YRFR.NLQVEFEQRYQITFNQKTFEDLFGPYLHPL..YFLSFR.DWQQE.RK.YS.PL..AE.KS.YQFLS...HWLTDL..A..RQFEIPLENKDLIMLKLHNT...LQTEG.IETRA.IFLMSNRKQQFCQLIKDKDIEFYHKIH...QGI.LEYRQLFH..KN..D..NIQIVYHMIYLVYITWTNL.....................................................
A0A0X8FM36_9LACT/173-363             .........................nlqd----FDDLI...QDVALEINYNDYFIDYR.HLRFY...IAVNFFRYQAGHLT..E...----..DFT.D.KAE.QVIEQ.-...-LSP.QVLDRLQQFFGQAMTPALAKQIFGRHVARD..FYYTIA.EMHEK.LP.QN.NY..YS.QL.NAMFV...QQMDLV..C..QEFNMTLANRDLVILEMHNS...YFLNT.NPGNR.KYILHNHSAIIISDLRQHYPKVIDLL-...---.--------..--..-..-------------------itsyqnvpask..........................................
A0A4R9BZY2_9FIRM/176-392             ...........ntikkaiteyfkinnink---------...-------------FEYS.YLEIMswtCAVNLHRTKLNFPV..-...ISQM..ETN.K.INY.DIIKN.L...LKSN.-ILQNIFRTFYIPLTENNLINIFYNYVHVD..LVHTFK.EFTDK.AD.YS.PN..IA.IS.LH--R...GFSDTF..SikNKYNLQLNNIENLIISVHNS...AVLYN.SDIKS.NCVIYNRRKMYIDQIYKQFPELVTDIK...TYL.SNYLTSLK..GS..I..KKNEVEHLTYVAVS-----twkgl................................................
H3NDN7_9LACT/175-400                 ............................n-EAELDDFL...WYFVKALDVSIQFISFT.SFKIY...TYVNIQRYKQGNIV..DpqtMNTE..NYL.N.QLF.DNLNN.D..pDKIQ.ELKDMISHVLNIPFSTEMIGQIFHNYMQSE..YCLNYDdLISNI.QS.NE.KY..SS.--.-LLLNl.dSMLYKL..K..KEFEIELPNKFDVILELHNA...THSHN.IDLGS.NYLLIRHNHYFCNHMEKIIPFFYERAK...ELI.RLFINQYH..SS..KkmDTTLHSYLMYTLIVNWQNL.....................................................
B9DT24_STRU0/177-394                 ............................n-EIALTSLV...DMTASKFSHRVTHSLFA.YLKIM...SAVNLIRFSKGYRV..N..eVYPR..SC-.-.SLY.EKLKE.D...PTFL.HLSELFWRDFGKPLDQVALSEMFSTYFRQD..LILN-A.ELDRQ.NT.DK.EV..EG.VT.YEDML...ETLEGI..E..NRFGMPIANKSEISLLIYNA...LILKE.HDIYE.NFLVYDYREPYIAYFNDSYPKLLEAFQ...EAL.LAPFKAKG..VE..L..AKERQNHLLYILLVNWDNL.....................................................
E1M6G3_9STRE/173-390                 ............................s-KKDIEEFV...AFFLKMTGFPANYANSF.QLETQ...IAVNLHRFKIGTTI..Q...TTSA..ST-.-.NDL.PLYDQ.L...PEFQ.DQLEPLAKRLNIEVNRHTLEQIFDSYTQKG..IFFTVE.EFLAA.RS.ED.KQ..VD.QS.YHAAR...DVLDNL..T..REFGIHFTNTDELVWHLHNT...ALLER.QEINS.ESIISHNKSYTLNKIKKFFPEFYEAAV...FEM.MRYKSSLG..QK..E..HAYAVVHLVYTLFTHASDL.....................................................
S0KQC2_9ENTE/175-392                 ...........................sd--NALSTLV...TALLKENKLPQNYRQHE.QLYFS...GAVSIWRQNNGHLLpqE...IEKS..GFL.KaESS.STTNA.V...VQLK.ETLMSINWHFNFLETFWTVCHDYVL-----..--LSFA.HFQQA.QK.RN.PR..IK.RL.AQRTN...HYLDALlsS..TKQNIASLEKEELIWHFCNE...NYIHL.RNCDF.IAILSNCRREFVLNYEKKFPNVITGLK...KFI.NNYHNKYQ..IH..I..TSDQVYQQLYLIITL----lpqi.................................................
Q8DNN5_STRR6/192-411                 .............................SSEPLSQLL...ELVYKETSFPMNLSTHR.MLKLL...LVTNLYRIKFGHFM..E...VDKD..SFN.D.QSL.DFLMQ.A...EGIE.GVAQSFESEYNISLDEEVVCQLFVSYFQKM..FFIDES.LFMKC.VK.KD.SY..VE.KS.YHLLS...DFIDQI..S..VKYQIEIENKDNLIWHLHNT...AHLYR.QELFT.EFILFDQKGNTIRNFQNIFPKFVSDVK...KEL.SHYLETLE..VC..S..SSMMVNHLSYTFITHTKHL.....................................................
A0A2N6SQ50_9LACT/19-238              .......................aeapfd------QIA...QVYLDHFETQINVGSYR.TLKLS...LLINLMRFKQGFFA..Q...MNDE..GA-.K.RFV.E-TMS.A...ERKK.KLKNIIEKDLGVPYSISFVTQFLGPIANTC..YFLSQK.DILNI.FE.QL.PD..MI.GP.QTYLF...HFFEKI..E..SNFDLEIPNRTEIIDALHVA...SYHSF.LEIGN.KGIAYEPSFCFNQSVKTMYPKFYQMIQ...EGL.ATYVEMMP..YKseN..NSHIIDDLTMVL-------fvtwkgl..............................................
A0A1X7KM69_9BACL/173-359             .......................eqefar------QLL...AEFTAENEIDSSFFHQK.FLEIT...ILLCLIRMRNGHVR..P...VDES..FPT.D.IST.AFLDN.S...EMAS.A----CSQLFGISLNESELQQLFFMFLRPE..AARSEK.HLMEL.VR.RK.QCnaHH.RV.YQI-E...GFLDRL..S..ERLGIPIPNKRTLLLKLYNV...-----.-----.---------------------------...---.--------..--..-..-------------------qtlfeydkkydleadseffyehavktfpyfveavkevlke.............
A3CQR4_STRSV/173-392                 ...........................sv--EPLCKLL...ALVYKETAFPVNFATQR.MLKLL...LVTNLYRIKFGHFL..E...VEKD..SFN.N.QLL.ESFMQ.A...EGIE.DIVASFDSEYHISLNKEVIGQLFVSYFQKM..FFIDEN.LFMSC.AK.TD.SY..VK.NS.YQLLS...DLIDQI..E..SKYNLKIDNNDNLIWHLHNT...AHLHR.QELST.EFILFDQKGNTIKNFQNIFPQFVSDIK...KGI.EYYLETLD..IH..S..TPMKVNHLSYTFITHSKHL.....................................................
A5M974_STREE/173-391                 .............................PEEDLTEFA...DFFYKITNYPMRFSIYR.MYKLM...IAISIHRVKNGHFI..D...LPNH..FY-.K.EYY.PLLKS.I...PNFQ.ETLAYFSKHLGLEMTPDTIAQIFISFLQND..IFLDPQ.EFFNS.LE.DN.SQ..AR.YS.YQLLS...QILERL..S..KQYKITFTNHDELIWHLHNT...AFFER.QEIFS.TPILFEQKALTIKKFEVYFPDFMGSAR...QEL.AQYRQAIG..QH..D..HPEQLEHLMYTILTHAENL.....................................................
#=GC seq_cons                        ............................t......phh....hhhp.hphshsas.ap.hl+lh...hslslhRhppGahl..p...lspp..ph..p.phh.phlhp......php.phht.hppphslplsppsltplFhsahpps..hhls.p.phhpt.hc.ps.sh..lp.po.hphlp...phlcpl..s..pcaslplsNpcpLlhpLHNs...shlpp.p-lts.phllacp+t.hlpphpphaPcFhptlp...ptl.tpahphht..h......p..hhpplhYshhhp.p.......................................................
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