#=GF ID   Pep_M12B_propep
#=GF AC   PF01562.20
#=GF DE   Reprolysin family propeptide
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_117 (release 4.0)
#=GF GA   22.70 22.70;
#=GF TC   22.70 22.70;
#=GF NC   22.60 22.60;
#=GF BM   hmmbuild --amino HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RC   See pages 196-198
#=GF RN   [1]
#=GF RM   7674922
#=GF RT   Evolutionary families of metallopeptidases. 
#=GF RA   Rawlings ND, Barrett AJ; 
#=GF RL   Meth Enzymol 1995;248:183-228.
#=GF DR   INTERPRO; IPR002870;
#=GF DR   MEROPS; M12;
#=GF DR   SCOP; 1fvl; fa;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This region is the propeptide for members of peptidase family
#=GF CC   M12B.  The propeptide contains a sequence motif similar to the
#=GF CC   "cysteine switch" of the matrixins. This motif is found at the C
#=GF CC   terminus of the alignment but is not well aligned.
#=GF SQ   8932
#=GS A0A287AJR1_PIG/34-164       AC A0A287AJR1.1
#=GS A0A3Q4I046_NEOBR/41-186     AC A0A3Q4I046.1
#=GS A0A2Y9P673_DELLE/67-208     AC A0A2Y9P673.1
#=GS A0A3P8WHZ1_CYNSE/39-187     AC A0A3P8WHZ1.1
#=GS A0A452GAL8_CAPHI/41-186     AC A0A452GAL8.1
#=GS A0A3P9ANJ0_ESOLU/57-198     AC A0A3P9ANJ0.1
#=GS A0A3P8UJB1_CYNSE/38-167     AC A0A3P8UJB1.1
#=GS H2SWL3_TAKRU/41-194         AC H2SWL3.2
#=GS A0A1A6H8D8_NEOLE/1-49       AC A0A1A6H8D8.1
#=GS A0A452E2H3_CAPHI/129-250    AC A0A452E2H3.1
#=GS W5NVP8_SHEEP/1-112          AC W5NVP8.1
#=GS G1T2M2_RABIT/24-156         AC G1T2M2.1
#=GS A0A3Q2L973_HORSE/21-144     AC A0A3Q2L973.1
#=GS A0A2R8ZWA8_PANPA/14-141     AC A0A2R8ZWA8.1
#=GS A0A3Q7SCY8_VULVU/20-156     AC A0A3Q7SCY8.1
#=GS A0A1U7Q7C8_MESAU/14-140     AC A0A1U7Q7C8.1
#=GS A0A1Y2REL3_9BACT/28-162     AC A0A1Y2REL3.1
#=GS A0A096NVV4_PAPAN/50-132     AC A0A096NVV4.2
#=GS A0A2R9A9H5_PANPA/20-94      AC A0A2R9A9H5.1
#=GS A0A2K5CWF2_AOTNA/47-166     AC A0A2K5CWF2.1
#=GS A0A2K5NTW7_CERAT/48-188     AC A0A2K5NTW7.1
#=GS A0A2P8YZ70_BLAGE/32-169     AC A0A2P8YZ70.1
#=GS A0A384BWZ5_URSMA/72-197     AC A0A384BWZ5.1
#=GS A0A0D9RUJ7_CHLSB/1-96       AC A0A0D9RUJ7.1
#=GS A0A2K5L5P3_CERAT/55-210     AC A0A2K5L5P3.1
#=GS A0A151MEA8_ALLMI/19-144     AC A0A151MEA8.1
#=GS A0A0R3WZ11_HYDTA/1-59       AC A0A0R3WZ11.1
#=GS A0A0V0ZLX5_9BILA/2-115      AC A0A0V0ZLX5.1
#=GS A0A2S4N9Z8_9FLAO/46-178     AC A0A2S4N9Z8.1
#=GS H3B4Z2_LATCH/53-169         AC H3B4Z2.1
#=GS I3J166_ORENI/1-116          AC I3J166.1
#=GS A0A093HCS1_STRCA/20-167     AC A0A093HCS1.1
#=GS K7D2R9_PANTR/39-167         AC K7D2R9.1
#=GS H2T9T4_TAKRU/24-152         AC H2T9T4.2
#=GS G1ND70_MELGA/1-141          AC G1ND70.2
#=GS A0A287DEC8_ICTTR/26-153     AC A0A287DEC8.1
#=GS A0A2I3TM46_PANTR/29-160     AC A0A2I3TM46.1
#=GS A0A493TAE4_ANAPP/50-197     AC A0A493TAE4.1
#=GS F6SJB8_CALJA/30-158         AC F6SJB8.2
#=GS F1PS22_CANLF/43-174         AC F1PS22.2
#=GS G3X3A4_SARHA/31-164         AC G3X3A4.1
#=GS A2RSG8_MOUSE/34-159         AC A2RSG8.1
#=GS A0A1W4UCG4_DROFC/52-191     AC A0A1W4UCG4.1
#=GS G1KNW2_ANOCA/44-198         AC G1KNW2.1
#=GS A0A091H101_9AVES/11-153     AC A0A091H101.1
#=GS I3K9K3_ORENI/6-173          AC I3K9K3.1
#=GS A0A0V0UVJ0_9BILA/57-201     AC A0A0V0UVJ0.1
#=GS A0A2U3WRZ3_ODORO/32-153     AC A0A2U3WRZ3.1
#=GS A0A384AWE3_BALAS/139-283    AC A0A384AWE3.1
#=GS A0A452FAF5_CAPHI/34-163     AC A0A452FAF5.1
#=GS A0A0V0TXA4_9BILA/36-171     AC A0A0V0TXA4.1
#=GS A0A3P8Z7I3_ESOLU/17-171     AC A0A3P8Z7I3.1
#=GS A0A452CPR3_BALAS/34-159     AC A0A452CPR3.1
#=GS B3LZT1_DROAN/256-427        AC B3LZT1.2
#=GS A0A2R8MX54_CALJA/35-162     AC A0A2R8MX54.1
#=GS A0A267F7W0_9PLAT/55-186     AC A0A267F7W0.1
#=GS A0A2K6U5A2_SAIBB/25-168     AC A0A2K6U5A2.1
#=GS A0A2Y9JEB8_ENHLU/46-186     AC A0A2Y9JEB8.1
#=GS H3DA49_TETNG/1-56           AC H3DA49.1
#=GS A0A455CAH3_PHYMC/40-181     AC A0A455CAH3.1
#=GS F1PGL0_CANLF/43-176         AC F1PGL0.2
#=GS A0A0K0JSE2_BRUMA/39-175     AC A0A0K0JSE2.2
#=GS A0A2C9LI42_BIOGL/10-136     AC A0A2C9LI42.1
#=GS A0A3Q1G499_9TELE/45-190     AC A0A3Q1G499.1
#=GS A0A384CZW4_URSMA/79-207     AC A0A384CZW4.1
#=GS A0A2I3THI7_PANTR/22-158     AC A0A2I3THI7.1
#=GS F7ECZ8_MACMU/30-161         AC F7ECZ8.2
#=GS A0A0N4XJB1_NIPBR/43-147     AC A0A0N4XJB1.1
#=GS A0A3Q2CFB5_CYPVA/2-63       AC A0A3Q2CFB5.1
#=GS A0A2K5RL55_CEBCA/139-279    AC A0A2K5RL55.1
#=GS A0A3R7MLV1_PENVA/106-183    AC A0A3R7MLV1.1
#=GS Q400M8_DROME/40-188         AC Q400M8.2
#=GS A0A2K5CU39_AOTNA/27-156     AC A0A2K5CU39.1
#=GS A0A3Q2HXD0_HORSE/44-188     AC A0A3Q2HXD0.1
#=GS L5KCQ7_PTEAL/18-93          AC L5KCQ7.1
#=GS A0A2R9AGK0_PANPA/14-141     AC A0A2R9AGK0.1
#=GS A0A2Y9PSQ6_DELLE/38-168     AC A0A2Y9PSQ6.1
#=GS F6SG12_MACMU/35-163         AC F6SG12.2
#=GS A0A2B4RGB5_STYPI/268-405    AC A0A2B4RGB5.1
#=GS A0A088A5V6_APIME/30-163     AC A0A088A5V6.1
#=GS F7ED03_MACMU/29-158         AC F7ED03.2
#=GS A0A286XGU2_CAVPO/42-181     AC A0A286XGU2.1
#=GS A0A337S7N7_FELCA/148-274    AC A0A337S7N7.1
#=GS A0A401NH58_SCYTO/3-125      AC A0A401NH58.1
#=GS F6PN78_CALJA/41-186         AC F6PN78.2
#=GS M7BGT4_CHEMY/27-159         AC M7BGT4.1
#=GS F6R235_ORNAN/2-107          AC F6R235.2
#=GS A0A151WUP5_9HYME/15-152     AC A0A151WUP5.1
#=GS A0A2K5VEY7_MACFA/23-148     AC A0A2K5VEY7.1
#=GS A0A0V1BE18_TRISP/63-194     AC A0A0V1BE18.1
#=GS T1FFB6_HELRO/4-135          AC T1FFB6.1
#=GS A0A226P6L6_COLVI/665-813    AC A0A226P6L6.1
#=GS A0A151MEE5_ALLMI/5-144      AC A0A151MEE5.1
#=GS A0A3P8NW71_ASTCA/42-173     AC A0A3P8NW71.1
#=GS A0A452I6G3_9SAUR/1-80       AC A0A452I6G3.1
#=GS A0A3Q3NIR8_9TELE/25-163     AC A0A3Q3NIR8.1
#=GS A0A3B4YEK2_SERLL/1-82       AC A0A3B4YEK2.1
#=GS A0A2K5CYC5_AOTNA/24-157     AC A0A2K5CYC5.1
#=GS A0A3B4EVX6_9CICH/1-53       AC A0A3B4EVX6.1
#=GS A0A1S3LDJ2_SALSA/44-201     AC A0A1S3LDJ2.1
#=GS F4X616_ACREC/44-183         AC F4X616.1
#=GS A0A1I7W0P6_LOALO/82-178     AC A0A1I7W0P6.1
#=GS A0A2Y9DHD1_TRIMA/43-191     AC A0A2Y9DHD1.1
#=GS G3VJA9_SARHA/1-33           AC G3VJA9.1
#=GS ADAM2_RAT/20-147            AC Q63202.2
#=GS A0A182TLB6_9DIPT/77-228     AC A0A182TLB6.1
#=GS M3XDF4_FELCA/19-141         AC M3XDF4.1
#=GS G1NR58_MELGA/70-192         AC G1NR58.1
#=GS A0A3L8S0Z3_CHLGU/84-208     AC A0A3L8S0Z3.1
#=GS A0A2K6UUX4_SAIBB/24-69      AC A0A2K6UUX4.1
#=GS A0A452HLR6_9SAUR/47-186     AC A0A452HLR6.1
#=GS A0A2Y9KBC1_ENHLU/24-157     AC A0A2Y9KBC1.1
#=GS F7G3W7_CALJA/61-205         AC F7G3W7.1
#=GS A0A3Q2DP76_CYPVA/39-204     AC A0A3Q2DP76.1
#=GS F6ULE4_MACMU/44-184         AC F6ULE4.2
#=GS A0A2K6RUJ0_RHIRO/29-158     AC A0A2K6RUJ0.1
#=GS W5MM71_LEPOC/34-181         AC W5MM71.1
#=GS A0A1L8GI02_XENLA/1-131      AC A0A1L8GI02.1
#=GS F6X1B5_ORNAN/7-148          AC F6X1B5.1
#=GS A0A493SZG4_ANAPP/121-250    AC A0A493SZG4.1
#=GS A0A3M0KD32_HIRRU/54-128     AC A0A3M0KD32.1
#=GS A0A1W4WQD5_AGRPL/18-158     AC A0A1W4WQD5.1
#=GS A0A2Y9K358_ENHLU/27-156     AC A0A2Y9K358.1
#=GS E7FEN5_DANRE/41-197         AC E7FEN5.2
#=GS A0A2K5XPE0_MANLE/28-155     AC A0A2K5XPE0.1
#=GS A0A158NXT6_ATTCE/45-189     AC A0A158NXT6.1
#=GS A0A3B3QES9_9TELE/24-179     AC A0A3B3QES9.1
#=GS A0A3P8UNY4_CYNSE/16-155     AC A0A3P8UNY4.1
#=GS A0A2K6DC48_MACNE/15-137     AC A0A2K6DC48.1
#=GS G3X800_BOVIN/49-167         AC G3X800.2
#=GS H3DNF0_TETNG/5-131          AC H3DNF0.1
#=GS G3RE41_GORGO/30-158         AC G3RE41.2
#=GS A0A3B3V505_9TELE/13-167     AC A0A3B3V505.1
#=GS A0A3M0KZ91_HIRRU/1041-1177  AC A0A3M0KZ91.1
#=GS A0A3Q4HT74_NEOBR/1-119      AC A0A3Q4HT74.1
#=GS M4AL57_XIPMA/37-198         AC M4AL57.1
#=GS A0A3Q4GWA7_NEOBR/21-143     AC A0A3Q4GWA7.1
#=GS A0A182PPW9_9DIPT/66-218     AC A0A182PPW9.1
#=GS A0A1S3SUD9_SALSA/39-196     AC A0A1S3SUD9.1
#=GS A0A2Y9N1R6_DELLE/110-249    AC A0A2Y9N1R6.1
#=GS A0A2K6UNA7_SAIBB/28-157     AC A0A2K6UNA7.1
#=GS A0A182YLM6_ANOST/14-171     AC A0A182YLM6.1
#=GS A0A2K5K563_COLAP/69-208     AC A0A2K5K563.1
#=GS H2V0N1_TAKRU/34-178         AC H2V0N1.2
#=GS M3W8I1_FELCA/27-167         AC M3W8I1.1
#=GS G1TWM0_RABIT/38-161         AC G1TWM0.1
#=GS A0A452HLT7_9SAUR/47-186     AC A0A452HLT7.1
#=GS A0A1S2ZSJ2_ERIEU/27-149     AC A0A1S2ZSJ2.1
#=GS A0A286Y3F4_CAVPO/26-163     AC A0A286Y3F4.1
#=GS H0VH24_CAVPO/1-87           AC H0VH24.2
#=GS G1LAT3_AILME/43-184         AC G1LAT3.1
#=GS A0A226EZH3_FOLCA/342-509    AC A0A226EZH3.1
#=GS G3QFW5_GORGO/37-173         AC G3QFW5.1
#=GS A0A3B4UG44_SERDU/27-159     AC A0A3B4UG44.1
#=GS A0A2I3N5C4_PAPAN/36-180     AC A0A2I3N5C4.1
#=GS A0A3Q7T3L5_VULVU/24-157     AC A0A3Q7T3L5.1
#=GS F6ZXN7_HORSE/36-152         AC F6ZXN7.2
#=GS A0A2J7R4T8_9NEOP/47-178     AC A0A2J7R4T8.1
#=GS A0A0V1P068_9BILA/53-195     AC A0A0V1P068.1
#=GS A0A140TAH8_RAT/14-142       AC A0A140TAH8.1
#=GS R0K6G7_ANAPL/4-135          AC R0K6G7.1
#=GS A0A2U3W4P0_ODORO/33-159     AC A0A2U3W4P0.1
#=GS A0A096NMW5_PAPAN/44-184     AC A0A096NMW5.1
#=GS H3BZB9_TETNG/1-105          AC H3BZB9.1
#=GS A0A2Y9E106_TRIMA/151-279    AC A0A2Y9E106.1
#=GS A0A3B3CN99_ORYME/61-201     AC A0A3B3CN99.1
#=GS A0A087XUK0_POEFO/41-193     AC A0A087XUK0.2
#=GS A0A498SMU7_ACAVI/49-186     AC A0A498SMU7.1
#=GS A0A3Q0DCL3_MESAU/47-186     AC A0A3Q0DCL3.1
#=GS W5P3S1_SHEEP/76-196         AC W5P3S1.1
#=GS A0A3Q0ILD4_DIACI/98-219     AC A0A3Q0ILD4.1
#=GS H0XWN7_OTOGA/53-163         AC H0XWN7.1
#=GS A0A3B4A5S5_9GOBI/80-160     AC A0A3B4A5S5.1
#=GS A0A2U9AY63_SCOMX/51-193     AC A0A2U9AY63.1
#=GS A0A384AU50_BALAS/4-143      AC A0A384AU50.1
#=GS A0A2K5XKM3_MANLE/57-181     AC A0A2K5XKM3.1
#=GS A0A3P8P571_ASTCA/64-203     AC A0A3P8P571.1
#=GS A0A2K6C5F5_MACNE/31-182     AC A0A2K6C5F5.1
#=GS G3RHP4_GORGO/49-207         AC G3RHP4.2
#=GS A0A484AZ98_DRONA/5-85       AC A0A484AZ98.1
#=GS M3XN11_MUSPF/4-143          AC M3XN11.1
#=GS A0A1V4KHH0_PATFA/534-634    AC A0A1V4KHH0.1
#=GS A0A3Q4N4Q3_NEOBR/22-150     AC A0A3Q4N4Q3.1
#=GS A0A3B4EMJ4_PYGNA/39-195     AC A0A3B4EMJ4.1
#=GS A0A1W4V3G5_DROFC/66-214     AC A0A1W4V3G5.1
#=GS A0A2K5JLK3_COLAP/1-107      AC A0A2K5JLK3.1
#=GS ATS10_HUMAN/40-180          AC Q9H324.2
#=GS A0A182H6P8_AEDAL/1-77       AC A0A182H6P8.1
#=GS A0A1S3A2H2_ERIEU/29-158     AC A0A1S3A2H2.1
#=GS A0A182M2U8_9DIPT/12-95      AC A0A182M2U8.1
#=GS A0A3Q2GZU5_HORSE/2-117      AC A0A3Q2GZU5.1
#=GS G1K9M0_ANOCA/34-166         AC G1K9M0.1
#=GS A0A3Q1MVL8_BOVIN/34-189     AC A0A3Q1MVL8.1
#=GS A0A2U3VK86_ODORO/46-167     AC A0A2U3VK86.1
#=GS A0A2K5NWY4_CERAT/110-249    AC A0A2K5NWY4.1
#=GS A0A1S3RWC9_SALSA/79-240     AC A0A1S3RWC9.1
#=GS A0A2K5UET7_MACFA/37-158     AC A0A2K5UET7.1
#=GS A0A0C9LRV5_9FUNG/12-126     AC A0A0C9LRV5.1
#=GS A0A1B0AVD5_9MUSC/27-164     AC A0A1B0AVD5.1
#=GS A0A3B4GH54_9CICH/79-131     AC A0A3B4GH54.1
#=GS F7FU21_MONDO/4-116          AC F7FU21.1
#=GS A0A3Q4G0M0_NEOBR/1-126      AC A0A3Q4G0M0.1
#=GS C3ZPX4_BRAFL/45-210         AC C3ZPX4.1
#=GS A0A3Q4M3W5_NEOBR/20-136     AC A0A3Q4M3W5.1
#=GS A0A3B5BL94_9TELE/41-186     AC A0A3B5BL94.1
#=GS A0A1D5R8V6_MACMU/19-136     AC A0A1D5R8V6.1
#=GS A0A3P9NG52_POERE/64-203     AC A0A3P9NG52.1
#=GS A0A3B1IK77_ASTMX/39-198     AC A0A3B1IK77.1
#=GS K7JNF7_NASVI/15-154         AC K7JNF7.1
#=GS A0A452IPQ1_9SAUR/11-146     AC A0A452IPQ1.1
#=GS A0A401Q858_SCYTO/1-45       AC A0A401Q858.1
#=GS A0A3Q7T3J2_VULVU/35-163     AC A0A3Q7T3J2.1
#=GS A0A3B4YF53_SERLL/3-101      AC A0A3B4YF53.1
#=GS G3P523_GASAC/1-81           AC G3P523.1
#=GS F1S046_PIG/73-217           AC F1S046.2
#=GS A0A3Q2W1C2_HAPBU/64-203     AC A0A3Q2W1C2.1
#=GS A0A3B3UGS1_9TELE/28-193     AC A0A3B3UGS1.1
#=GS A0A401T4M3_CHIPU/110-245    AC A0A401T4M3.1
#=GS A0A091ETG9_CORBR/42-181     AC A0A091ETG9.1
#=GS H3CD70_TETNG/21-155         AC H3CD70.1
#=GS H2PQ52_PONAB/13-141         AC H2PQ52.1
#=GS A0A3Q3GH80_9LABR/44-182     AC A0A3Q3GH80.1
#=GS A0A068RMI3_9FUNG/24-170     AC A0A068RMI3.1
#=GS A0A1U7TAQ0_TARSY/19-157     AC A0A1U7TAQ0.1
#=GS A0A1S3N5R4_SALSA/41-216     AC A0A1S3N5R4.1
#=GS A0A369S277_9METZ/8-108      AC A0A369S277.1
#=GS F6SF07_MACMU/40-185         AC F6SF07.2
#=GS F7E7S0_CALJA/1-97           AC F7E7S0.2
#=GS A0A3B4VJ60_SERDU/24-185     AC A0A3B4VJ60.1
#=GS A0A455BE33_PHYMC/41-186     AC A0A455BE33.1
#=GS A0A3B3W190_9TELE/10-96      AC A0A3B3W190.1
#=GS M3XAZ6_FELCA/38-156         AC M3XAZ6.3
#=GS A0A093G9L9_DRYPU/9-138      AC A0A093G9L9.1
#=GS A0A2K5Q9W6_CEBCA/42-178     AC A0A2K5Q9W6.1
#=GS A0A2R9CI30_PANPA/54-181     AC A0A2R9CI30.1
#=GS A0A2K5ZFN8_MANLE/10-165     AC A0A2K5ZFN8.1
#=GS A0A1S2ZB84_ERIEU/338-482    AC A0A1S2ZB84.1
#=GS A0A3B3TSV9_9TELE/41-190     AC A0A3B3TSV9.1
#=GS A0A452J322_9SAUR/25-165     AC A0A452J322.1
#=GS A0A3B4ZY40_9TELE/64-203     AC A0A3B4ZY40.1
#=GS A0A2G5UPD4_9PELO/28-173     AC A0A2G5UPD4.1
#=GS Q5JRP2_HUMAN/39-165         AC Q5JRP2.1
#=GS A0A2U3W4K4_ODORO/32-159     AC A0A2U3W4K4.1
#=GS W5JMW2_ANODA/17-164         AC W5JMW2.1
#=GS H3DIW0_TETNG/38-170         AC H3DIW0.1
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