GenomeNet

Database: Pfam
Entry: Pneumo_NS1
LinkDB: Pneumo_NS1
Original site: Pneumo_NS1 
#=GF ID   Pneumo_NS1
#=GF AC   PF03438.16
#=GF DE   Pneumovirus NS1 protein
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_3221 (release 6.6)
#=GF GA   27.00 27.00;
#=GF TC   34.20 220.70;
#=GF NC   24.00 17.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   10982380
#=GF RT   Recombinant respiratory syncytial virus that does not express
#=GF RT   the NS1 or M2-2 protein is highly attenuated and immunogenic in
#=GF RT   chimpanzees. 
#=GF RA   Teng MN, Whitehead SS, Bermingham A, St Claire M, Elkins WR,
#=GF RA   Murphy BR, Collins PL; 
#=GF RL   J Virol 2000;74:9317-9321.
#=GF RN   [2]
#=GF RM   10949949
#=GF RT   Domains of human respiratory syncytial virus P protein essential
#=GF RT   for homodimerization and for binding to N and NS1 protein. 
#=GF RA   Hengst U, Kiefer P; 
#=GF RL   Virus Genes 2000;20:221-225.
#=GF RN   [3]
#=GF RM   9445048
#=GF RT   The NS1 protein of human respiratory syncytial virus is a potent
#=GF RT   inhibitor of minigenome transcription and RNA replication. 
#=GF RA   Atreya PL, Peeples ME, Collins PL; 
#=GF RL   J Virol 1998;72:1452-1461.
#=GF DR   INTERPRO; IPR005099;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This non-structural protein is one of two found in
#=GF CC   pneumoviruses. The protein is about 140 amino acids in length.
#=GF CC   The NS1 protein appears to be important for efficient
#=GF CC   replication but not essential [1]. The NS1 protein has been
#=GF CC   shown by yeast two-hybrid to interact with the viral P protein
#=GF CC   [2]. This protein is also known as the 1C protein. It has also
#=GF CC   been shown that NS1 can potently inhibit transcription and RNA
#=GF CC   replication [3].
#=GF SQ   3
#=GS NS1_HRSVB/1-136  AC O42083.1
#=GS NS1_HRSVA/1-136  AC P0DOE9.1
#=GS NS1_BRSVA/1-136  AC Q65694.1
NS1_HRSVB/1-136             MGCNSLSMIKVRLQNLFDNDEVALLKITCYTDKLILLTNALAKAAIHTIKLNGIVFIHVITSSEVCPDNNIVVKSNFTTMPILQNGGYIWELIELTHCSQLNGLMDDNCEIKFSKRLSDSVMTNYMNQISDLLGLD
NS1_HRSVA/1-136             MGSNSLSMIKVRLQNLFDNDEVALLKITCYTDKLIHLTNALAKAVIHTIKLNGIVFVHVITSSDICPNNNIVVKSNFTTMPVLQNGGYIWEMMELTHCSQPNGLLDDNCEIKFSKKLSDSTMTNYMNQLSELLGFD
NS1_BRSVA/1-136             MGSETLSVIQVRLRNIYDNDKVALLKITCHTNRLILLTHTLAKSVIHTIKLSGIVFIHIITSSDYCPTSDIINSANFTSMPILQNGGYIWELMELTHCFQTNGLIDDNCEITFSKRLSDSELAKYSNQLSTLLGLN
#=GC seq_cons               MGSNSLSMIKVRLQNLFDNDEVALLKITCYTDKLILLTNALAKAVIHTIKLNGIVFIHVITSSDlCPsNNIVVKSNFTTMPILQNGGYIWELMELTHCSQsNGLlDDNCEIKFSKRLSDSsMTNYMNQLS-LLGLD
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