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Database: Pfam
Entry: Polo_box_2
LinkDB: Polo_box_2
Original site: Polo_box_2 
#=GF ID   Polo_box_2
#=GF AC   PF18531.1
#=GF DE   Polo box domain
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF01983
#=GF GA   31.90 31.90;
#=GF TC   36.00 49.90;
#=GF NC   27.80 26.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   24980795
#=GF RT   Structure of the C. elegans ZYG-1 cryptic polo box suggests a
#=GF RT   conserved mechanism for centriolar docking of Plk4 kinases.
#=GF RA   Shimanovskaya E, Viscardi V, Lesigang J, Lettman MM, Qiao R,
#=GF RA   Svergun DI, Round A, Oegema K, Dong G;
#=GF RL   Structure. 2014;22:1090-1104.
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   In metazoans, Plk4 kinases control daughter centriole assembly.
#=GF CC   Plk4 homologs have an N-terminal kinase domain, a C-terminal
#=GF CC   polo box, and a central domain termed the 'cryptic polo box'
#=GF CC   (CPB) that has been shown to dimerize, to be sufficient for
#=GF CC   centriole localization and to be required for Plk4 to promote
#=GF CC   centriole assembly. Probable serine/threonine-protein kinase
#=GF CC   zyg-1 (EC:2.7.11.1) (ZYG-1) is a Plk4 homlog found in C.
#=GF CC   elegans. Crystal structure for the CPB of C. elegans ZYG-1,
#=GF CC   reveals that it forms a Z-shaped dimer containing an
#=GF CC   intermolecular beta-sheet with an extended basic surface patch.
#=GF CC   Electrostatic interactions between the basic patch on the ZYG-1
#=GF CC   CPB dimer and the SPD-2 acidic region dock ZYG-1 onto centrioles
#=GF CC   to promote new centriole assembly.  ZYG-1 CPB contains two
#=GF CC   tandem polo boxes (PB1 and PB2), each containing a six-stranded
#=GF CC   beta-sheet with an alpha-helix packed against one side [1].
#=GF SQ   21
#=GS ZYG1_CAEBR/350-461        AC Q621J7.1
#=GS A0A016TU94_9BILA/363-452  AC A0A016TU94.1
#=GS W6NG95_HAECO/361-450      AC W6NG95.1
#=GS A0A0D8XFY7_DICVI/365-477  AC A0A0D8XFY7.1
#=GS A0A2A2JBR1_9BILA/270-380  AC A0A2A2JBR1.1
#=GS A0A2H2IJX7_CAEJA/282-370  AC A0A2H2IJX7.1
#=GS A0A0N4WBL6_HAEPC/361-450  AC A0A0N4WBL6.1
#=GS U6NQW1_HAECO/288-400      AC U6NQW1.1
#=GS A0A2H2ITU7_CAEJA/98-207   AC A0A2H2ITU7.1
#=GS W2SUZ2_NECAM/337-432      AC W2SUZ2.1
#=GS A0A1I7WWC8_HETBA/170-241  AC A0A1I7WWC8.1
#=GS A0A2A2JC52_9BILA/274-384  AC A0A2A2JC52.1
#=GS A0A1I7TSL5_9PELO/350-391  AC A0A1I7TSL5.1
#=GS A0A261CF72_9PELO/362-472  AC A0A261CF72.1
#=GS E3M4S5_CAERE/362-450      AC E3M4S5.1
#=GS A0A2G5V5D0_9PELO/357-445  AC A0A2G5V5D0.1
#=GS ZYG1_CAEEL/351-460        AC Q9GT24.1
#=GS ZYG1_CAEEL/351-460        DR PDB; 4NKB A; 351-460;
#=GS ZYG1_CAEEL/351-460        DR PDB; 4NKB B; 351-460;
#=GS A0A0N4XIG4_NIPBR/273-355  AC A0A0N4XIG4.1
#=GS G0PJX6_CAEBE/85-173       AC G0PJX6.1
#=GS A0A183FKK4_HELBK/65-162   AC A0A183FKK4.1
#=GS W6NB67_HAECO/361-473      AC W6NB67.1
ZYG1_CAEBR/350-461                   .....QIWPIRMERLVGQRVRTPGGRYIVEMNTRCRFEVVSKGNIVLRILVVEYDPHLLI.QTVYVHKMSNRVEHARNETDDLIELTR..SPISYTS.LSQLPKEVMNDYMRLEKMMVSTI...............
A0A016TU94_9BILA/363-452             ...pp--WPLPIHRCGGTKLVTAAGRYVIVDDHTMVFEVANKSGFITKIVEISVGTRGRQ.QVIFGKPLHLDVKRPL-EHDPLISMTRerD------.-----------------------taaltr.........
W6NG95_HAECO/361-450                 .....PIWPLPIRRCGGTKLLSAAGRYIIVDDNLVVFEVANKSGFIAKIVTVSIDDHGKQ.QVTFGRPMHSEVRRPL-ENDNLIAVDRrhESLPLT-.-----------------------r..............
A0A0D8XFY7_DICVI/365-477             .....PVWPLPIYRCGGTRMVTAAGRYIILDDNLLIFEVANKSGLITKIVTVTIDIRGKQ.QVIFDKPLHMDVKQPK-EHDSLVVPAEgyDSKPFTS.YSAMNRYERDLYAQMANAVEAMR...............
A0A2A2JBR1_9BILA/270-380             ...en--WPLKLTRLGNNTAVLKTSRVFVENDSRAIMEIASSKGVVTDIMIVTIRY-GVQ.TVTLYKPVQNNVQKANDSTTPRVEIGQ..SGMRYKN.FSDLERRLQQHYDNLYKCVEN--fr.............
A0A2H2IJX7_CAEJA/282-370             ....n-MWPIRMERLAGQRIRTQGGRYVAELNTRCRFEVATRGDIITRILITEYDPYRRI.QTVFVHRIAERKERGREEGDDLIELTR..NPMVYT-.-----------------------a..............
A0A0N4WBL6_HAEPC/361-450             .....PIWPLPIRRCGGTKLLSAAGRYVIVDDNLVVFEVANKSGFIAKIVTVSIDDHGKQ.QVTFGRPMHPEIRRPL-ENDNLIAKDRrhESLPLT-.-----------------------r..............
U6NQW1_HAECO/288-400                 .....PIWPLPIRRCGGTKLLSAAGRYIIVDDNLVVFEVANKSGFIAKIVTVSIDDHGKQ.QVTFGRPMHSEVRRPL-ENDNLIAVDRrhESLPLTS.YASMSRHERDLYAQLANAVEAMR...............
A0A2H2ITU7_CAEJA/98-207              ....d-MWPIRMERLAGQRIRTQGGRYVAELNTRCRFEVATRGDITTRILITEYDPYRRI.QTVFVHRIADRRERGREEGDDLIELTR..NPMVYTAeFSAFH------------------teynktnnrkaavdq
W2SUZ2_NECAM/337-432                 .idva---------------------YVIVDDHKLVFEVANKNGFITKIVEVLIGTRGRQ.QVAFGKPAHSNVGLPL-EHDGLIPLARerNTVALTS.FSSMNRHERDVYAQIANAVEAMR...............
A0A1I7WWC8_HETBA/170-241             ....p--WPIDFKRCGGAKLVSAGGRYVVVNNQKVVFEMVNKNGFISKIVIVTLSENNCQ.QV--EKRMV------------------..-------.-----------------------qkletkgvqii....
A0A2A2JC52_9BILA/274-384             ...en--WPLKLTRLGNNTAVLKTSRVFVENDSRAIMEIASSKGVVTDIMIVTIRY-GVQ.TVTLYKPVQNNVQKANDSTTPRVEIGQ..SGMRYKN.FSDLERRLQQHYDNLYKCVEN--fr.............
A0A1I7TSL5_9PELO/350-391             .....QTWPIRMERLAGQRIRTAGGRYIVEMDTRCRFEVASQGNVI--------------.---------------------------..-------.-----------------------e..............
A0A261CF72_9PELO/362-472             .....QIWPIRMERLAGQRLRTAGGRYIIESDSRCRFEVAATGDVVKRILIVEYNRYQQK.QTVYVHKITDRVK-SRNERDELIDVPG..MPVVYTT.LSQLTKEVLNDYLRLQKMIVSN-i..............
E3M4S5_CAERE/362-450                 .....QIWPIRMERLAGQRLHTAGGRYIIESDSRCRFEVAGQHEVVLRILIVEYNRYQQK.QTVYVHKIKNRGEKCRNERDELIDVSE..PLAVYT-.-----------------------t..............
A0A2G5V5D0_9PELO/357-445             .....QIWPIRMERLVGQRVRTPGGRYIVEMNTRCRFEVVSKGNIVLRILVVEYDPHLLI.QTVYVHKMSNRVEHARNETDDLIELTR..SPISYTS.-----------------------...............
ZYG1_CAEEL/351-460                   .....QLWPIRMDRLEGQRVCTAGGRYIVELDTRCRFEVAAQGNFVKRILIVEVDE--MV.QTVYVHRIPDRTVRGRNGEEELITLTN..NPFVYTS.YSQMPKEVQNDYMRLQKMVAVTI...............
#=GR ZYG1_CAEEL/351-460        SS    .....--SS---TT-TT-EEE-SSEEEEEEETTEEEEEEE-TTSBEEEEEEEEEET--TE.EEEEEEE--TTSSB---TTS------S..S-EEESS.GGGS-HHHHHHHHHHHHHHHTCC...............
A0A0N4XIG4_NIPBR/273-355             glgsr-----------------SGGEYIIVDDNLLVFEVANKNGLITKIITVSIDSHSRQ.EIVFGRPLQANISRPL-ERDPLLQTDKsyD------.-----------------------applsryfyid....
G0PJX6_CAEBE/85-173                  .....QLWPLRMERLNGQRIRTTAGRYIVEMDTRCRFEIASTGDIVRRIMIVELDDHNQQsQTVYVHRISDRIVQGRNEKDELIELSK..KPSVY--.-----------------------r..............
A0A183FKK4_HELBK/65-162              .....PLWPLPLHRCGGTRLLSAAGRYVIVDDSLMVFEVANKSGFIAKIVTISIDSHGRQ.QVTFDRPMNADVRRPL-EQDALIPVDRtyQSTPLTS.LT---------------------gsmlis.........
W6NB67_HAECO/361-473                 .....PIWPLPIRRCGGTKLLSAAGRYIIVDDNLVVFEVANKSGFIAKIVTVSIDDHGKQ.QVTFGRPMHSEVRRPL-ENDNLIAVDRrhESLPLTS.YASMSRHERDLYAQLANAVEAMR...............
#=GC SS_cons                         .....--SS---TT-TT-EEE-SSEEEEEEETTEEEEEEE-TTSBEEEEEEEEEET--TE.EEEEEEE--TTSSB---TTS------S..S-EEESS.GGGS-HHHHHHHHHHHHHHHTCC...............
#=GC seq_cons                        ......hWPl.hcRhuGp+lhouuGRYll.sDs+shFEVAs+ushls+IlhVplDsaspQ.Qssas+.hpsclc+sh.EpDsLItls+..pshshT........................................
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