GenomeNet

Database: Pfam
Entry: Pox_ATPase-GT
LinkDB: Pox_ATPase-GT
Original site: Pox_ATPase-GT 
#=GF ID   Pox_ATPase-GT
#=GF AC   PF10640.9
#=GF DE   mRNA capping enzyme N-terminal, ATPase and guanylyltransferase
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   Karlin D
#=GF GA   25.00 25.00;
#=GF TC   101.80 100.80;
#=GF NC   22.10 22.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   8227060
#=GF RT   Identification of the vaccinia virus mRNA guanyltransferase
#=GF RT   active site lysine. 
#=GF RA   Niles EG, Christen L; 
#=GF RL   J Biol Chem. 1993;268:24986-24989.
#=GF RN   [2]
#=GF RM   8662635
#=GF RT   Domain structure of the vaccinia virus mRNA capping enzyme.
#=GF RT   Expression in Escherichia coli of a subdomain possessing the RNA
#=GF RT   5'-triphosphatase and guanylyltransferase activities and a
#=GF RT   kinetic comparison to the full-size enzyme. 
#=GF RA   Myette JR, Niles EG; 
#=GF RL   J Biol Chem. 1996;271:11936-11944.
#=GF RN   [3]
#=GF RM   17989694
#=GF RT   Structural insights into the mechanism and evolution of the
#=GF RT   vaccinia virus mRNA cap N7 methyl-transferase. 
#=GF RA   De la Pena M, Kyrieleis OJ, Cusack S; 
#=GF RL   EMBO J. 2007;26:4913-4925.
#=GF DR   INTERPRO; IPR019602;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain is the N-terminus of the large subunit viral mRNA
#=GF CC   capping enzyme, and carries both the ATPase and the
#=GF CC   guanylyltransferase activities of the enzyme. The
#=GF CC   guanylyltransferase enzymatic region runs from residues 242
#=GF CC   (leucine)-273(arginine) [1], the core of the acitve site being
#=GF CC   the lysine residue at 260 [2]. The ATPase activity is at the
#=GF CC   very N-terminal part of the domain [3].
#=GF SQ   38
#=GS G3EIG4_9POXV/26-336      AC G3EIG4.1
#=GS Q08FR4_DPV83/26-337      AC Q08FR4.1
#=GS R4JNM0_9POXV/26-340      AC R4JNM0.1
#=GS MCEL_RFVKA/25-333        AC P25950.1
#=GS R4ZFK7_9POXV/20-373      AC R4ZFK7.1
#=GS A0A223FMV0_9POXV/26-336  AC A0A223FMV0.1
#=GS MCEL_VACCC/27-338        AC P20979.1
#=GS A0A0H4Y1K2_9POXV/20-327  AC A0A0H4Y1K2.1
#=GS MCEL_FOWPN/28-343        AC Q9J584.1
#=GS MCEL_VAR67/27-338        AC P33057.1
#=GS D5FLE8_RACVI/27-336      AC D5FLE8.1
#=GS A0A1B1MRC8_9POXV/27-341  AC A0A1B1MRC8.1
#=GS A0A0K1LDX7_9POXV/27-338  AC A0A0K1LDX7.1
#=GS Q6TVC4_9POXV/22-336      AC Q6TVC4.1
#=GS Q070E2_CPRVZ/26-341      AC Q070E2.1
#=GS A0A1L3IZK0_9POXV/28-337  AC A0A1L3IZK0.1
#=GS MCEL_VACCW/27-338        AC P04298.1
#=GS MCEL_VACCW/27-338        DR PDB; 4CKB A; 34-338;
#=GS MCEL_VACCW/27-338        DR PDB; 4CKC D; 27-338;
#=GS MCEL_VACCW/27-338        DR PDB; 4CKE D; 27-338;
#=GS MCEL_VACCW/27-338        DR PDB; 4CKE A; 34-338;
#=GS MCEL_VACCW/27-338        DR PDB; 4CKC A; 27-338;
#=GS MCEL_VACCW/27-338        DR PDB; 4CKB D; 27-338;
#=GS A0A068ELN3_9POXV/28-343  AC A0A068ELN3.1
#=GS Q6TUT6_YMTV5/27-336      AC Q6TUT6.1
#=GS A0A097IVV1_9POXV/39-350  AC A0A097IVV1.1
#=GS U3UBK1_9POXV/26-337      AC U3UBK1.1
#=GS R4ZEP7_9POXV/20-347      AC R4ZEP7.1
#=GS D3IZL1_9POXV/22-335      AC D3IZL1.1
#=GS Q9Q8M4_MYXVL/24-332      AC Q9Q8M4.1
#=GS Q98257_MCV1/128-443      AC Q98257.1
#=GS A0A1Z3GCT8_9POXV/22-339  AC A0A1Z3GCT8.1
#=GS Q6VZF5_CNPV/28-341       AC Q6VZF5.1
#=GS Q0NPA3_9POXV/27-338      AC Q0NPA3.1
#=GS Q8JJP2_LSDVN/26-337      AC Q8JJP2.1
#=GS Q8V3L9_SWPV1/26-336      AC Q8V3L9.1
#=GS W6JL07_9POXV/21-375      AC W6JL07.1
#=GS A0A0A7M9R9_9POXV/30-343  AC A0A0A7M9R9.1
#=GS Q9YW26_MSEPV/18-376      AC Q9YW26.1
#=GS Q9EMR4_AMEPV/20-336      AC Q9EMR4.1
#=GS R4ZFB3_CBEPV/20-341      AC R4ZFB3.1
#=GS A9J1T1_VACCA/27-338      AC A9J1T1.1
#=GS A0A0M3ZRQ5_9POXV/27-342  AC A0A0M3ZRQ5.1
#=GS Q6TVQ6_ORFSA/22-335      AC Q6TVQ6.1
G3EIG4_9POXV/26-336                 ........n-QSATYDVNNELELIFTNPPLITLTNVF...NI.STLQESFIRFTVTN...-KDGVKIRTKIPLSKVHGLDIKNSQLVDVIENIV.WEKKTLINEIV......Y..N.KEVILRLSTEEKYIFLDY....KK..YGSSIKLELVNLIQSRTK.N.............FIIDFKIKYFLGSGAQS..KCSLLHSINHPKS.KPNMSLEIEFISMDN....KNVQYDKLLNELTTISRNIFMA.SPENVYLSP..IIKIPVNTFMLHK.QDIPALELENLYAVSKTD....................................GIPVTVKLKS....TGIY...CYFGHIGYIIRYPIKKNLDT.DIILFGEAIK..DKNQWIIYLIKLLEP..VIHDRLDERNYIESRL.................................
#=GR G3EIG4_9POXV/26-336      pAS   ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
Q08FR4_DPV83/26-337                 ........k-PKSLDDINHEVEIVFIQPPLITLNNVL...NI.SSKQESYILFSLTN...KEDRVKIRSYLPMSKVYGLDLKNIQLVDSIDNII.WEKKTLITEHI......V..D.KHCMVRYSTEEKHIFLDY....RK..YISAIRLELVNLIQLKIK.N.............ILIDFKIKYFLGSGAQA..KSSLLHVLNHPKS.KPNVSLEFEIISEND....YKIDKDIIFNEISTLFRNIFMG.NPKNIFMTP..EQKNPIKTRMIKK.QDLTGLELDNLYITTKTD....................................GVGSLIKINK....NGIF...CYFSHLNYSIRYNLLKPIDK.QIVLYGEALK..HGKMWNIFLIKLIEP..ILDDRIKEKDFINDEL.................................
#=GR Q08FR4_DPV83/26-337      pAS   ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
R4JNM0_9POXV/26-340                 .....kppl----KDDINHEFEIIFIDPPLIALSNIY...KI.STKHESFILFTVTD...KENSVKYRTTIPLSNIHGLDIKNVQLVESINNIV.WEKKTLISENK......L..S.SKCILKHSTEERHIFLDF....IK..YISAIKLELVNLIQVRAK.N.............FNIDFKFKYFLGSGAQS..KSSLLHVLNHPKS.KPNPTIEFEYVYNDI...gEKPSKKLLQNELKTLFRSVFMA.LPENIFIPQ.qILHMPIKTIMLKK.QDIINLDVEDLYATTKTD....................................GVPTIVNIIN....NNIY...CYFSHLNYIIKYESIHNFDK.SITLFGEAIK.nSNKQWIIYLIKLLTP..TFNTRFEEKEFIDKTL.................................
#=GR R4JNM0_9POXV/26-340      pAS   ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
MCEL_RFVKA/25-333                   ........n-PVQTDDMNHEVELTFIQPPVITLSTLL...PF.ATSQESYILFTVTN...--KGVKIRNRINLSKIHGLDLKNIQLVDSIDNII.WEKKTLVKEHK......I..D.SVALVKYSTEEKYIFLDY....KK..YLSAIKLELVNVVQVKVK.H.............VTVDFKFKYFLGSGAQA..KSSLLHVLNHPKS.KPNPSLEFEIIT-TD....EKIDSASLRKELIALFKLVFMA.SPSNIILDV..VFKNPVQTILLKK.NELPGIDLTNLYVTTKTD....................................GVGVLITVTN....KGIY...CFFTHLQYTIRYDTTFESNE.SVTLYGEAVK..QNNVWQIYLIKLITP..KVSDRFKEKEYVEERL.................................
#=GR MCEL_RFVKA/25-333        AS    ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
R4ZFK7_9POXV/20-373                 .......kl--DTNENIKNEVELTLINPDLMLLSNIYt.eNN.ESKKKTYLEYNLKF...SKKKSKLRQRHEY-DYSTYEIPNSHLTDRLTN-N.WETKTVIDEEKi....dI.nKhEHVLMRHNIEYI------....--..-DNNIELPLINDIFDRIS.VifvsqvyiiidsvLKIEFKIKSYIGPLSSN..KLSLSTHFNDIDTsRKNISYYLEIEILPN....IKLENNILQEKLEKAFSYIYKStNISNLSLVT.iKEPSRIKTFTIQY.NKLNTIDKDSYVMAIKIDgnvvnftvknsicsviiynviyknykcnidknieikGMGEYIKVNN...vKKIY..pFYFTEIKYVNR-KATNIIEN.RY--------..---------------..----------------dqiqfynsiitsfkepmqikfenkltlkfnenn
#=GR R4ZFK7_9POXV/20-373      pAS   ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
A0A223FMV0_9POXV/26-336             .......qk--STAYEVNNELELVFTNPPLITLTNVV...NI.STAQESFIRFTVTN...-KEGTKIRTKIPLSKVHGLDIKNSQLVDLVENIV.WEKKTLIKETK......L..H.KEVVLRLSTEERHIFLDY....KK..YGSSIKLELVNLIQSRTK.N.............FVIDFKLKYFLGSGAQA..KCSLLHSINHPKS.KPNISLEFEFISRDN....EKVPYDELLSELNTISRNIFMA.SPENVFLSP..IMKIPVNTYMLHK.QDIPGLELENLYAVTKTD....................................GIPVTVKINS....TGIY...CYFTHIGYIIRYPAKKILDT.TVVLFGEAIK..DKNQWSIYLIKLLEP..VINDRLEERSYIESKL.................................
#=GR A0A223FMV0_9POXV/26-336  pAS   ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
MCEL_VACCC/27-338                   .......qr--STAYEINNELELVFIKPPLITLTNVV...NI.STIQESFIRFTVTN...-KEGVKIRTKIPLSKVHGLDVKNVQLVDAIDNIV.WEKKSLVTENR......L..H.KECLLRLSTEERHIFLDY....KK..YGSSIRLELVNLIQAKTK.N.............FTIDFKLKYFLGSGAQS..KSSLLHAINHPKS.RPNTSLEIEFTPRDN....EKVPYDELIKELTTLSRHIFMA.SPENVILSP..PINAPIKTFMLPK.QDIVGLDLENLYAVTKTD....................................GIPITIRVTS....NGLY...CYFTHLGYIIRYPVKRIIDS.EVVVFGEAVK..-DKNWTVYLIKLIEPvnAINDRLEESKYVESKL.................................
#=GR MCEL_VACCC/27-338        AS    ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
A0A0H4Y1K2_9POXV/20-327             resnmdlei---------TELEFTQFDPSLLSLSKMFsnpNI.KPLTDSYLEYILNKtsdEGNNIKIRIRIDFAVVGGLELNNKQLLDYVEHGC.WESKETKD-IW......LspD.EFGRITSATEKQGTYINK....VI..QSGKINMIFVNRARVKFS.D.............FVVDFKLKRKLGNCRQG.nISNLYKSVNNAMY.PPNPSLEIEHTG--Q....FKKPWKDVKLEFTKVISWIIGH.PIEEILTTT.tPLFKIIPTSVITPaYLMNSIDPTQHKLTPKIN....................................GVGVMFKIDK....KHVLvqqMLGPKVISIWRYKHLLTVTE.DIYGSGEFIF..---------------..----------------dsdhskciypymilgh.................
#=GR A0A0H4Y1K2_9POXV/20-327  pAS   ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
MCEL_FOWPN/28-343                   ........i-NKVDESKHHEVELILFKPPIITLTNLY...NM.ATTTESYIEFTMLP..vDKPNTKFRNRIPLSKIHGLDVKNNQLVESLDGFI.WEEKSLLLKKD......I.sDnSSAIIKYSIEEKTLFVDY....KR..RNASIKLELVSVVRAKLR.N.............IVIDFKMKYFLGSGAQSanSSSLLCALNHPKN.KPSLYIEFEIMM-QD....KNISKKKLLEELNMSASALFLS.HPKYIRLCP..SINPILRTHLLKK.QDIININTDDLYITSKTD....................................GIFSHVYIEK....KSIF...CYFSHLGYIKEYTASREIEE.TIYLYAEMRK..EESILYLTVIKVLKP..CMEDRLSELAFVKNHL.................................
#=GR MCEL_FOWPN/28-343        AS    ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
MCEL_VAR67/27-338                   ......qgs---TAYEINNELELVFIKPPLITLTNVV...NI.STIQESFIRFTVTN...-KEGVKIRTKIPLSKVHGLDVKNVQLVDAIDNIV.WEKKSLVTENR......L..H.KACLLRLSTEERHIFLDY....KK..YGSSIRLELVNLIQAKTK.N.............FTIDFKLKYFLGSGAQS..KSSLLHAINHPKS.RPNTSLEIEFTPRDN....ETVPYDELIKELTTFSRHIFMA.SPENVILSP..PINAPIKTFMLPK.QDIVGMDLENLYAVTKTD....................................GIPITIRVTS....KGLY...CYFTHLGYIIRYPVKRIIDS.EVVVFGEAVK..-DKNWTVYLIKLIEPvnAISDRLEESKYVESKL.................................
#=GR MCEL_VAR67/27-338        AS    ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
D5FLE8_RACVI/27-336                 .......nh--STAYEINNELELVFIKPPLIALTNVV...SI.STIQESFIRFTVTN...-REGVKIRTKIPLSKVHGLDVKNVQLVEAIDNIV.WEKKTLVTETR......L..H.KECLLRLSTEERHIFLDY....KK..YGSSIRLELVNLIQAKTK.N.............FTIDFKLKYFLGSGAQS..KSSLLHAINHPKS.RPNTSLEIEFTPRED....EKVPYDELIKELTTVTRHIFMA.SPENVILSP..PISSPIKTFMLPK.QDIVGLDLENLYAVTKTD....................................GVPVTIRITS....KGLY...CYFTHLGYIIKYPVKRAIDT.DVVVFGEAIK..-DKNWTVYLIKLIEP..VIDDRLEESNYVDSKL.................................
#=GR D5FLE8_RACVI/27-336      pAS   ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
A0A1B1MRC8_9POXV/27-341             .......hn---PKEDKHHELELVFIHPPLITLSNIL...NI.STLVDSYVQFTVTM...SEDNSKIRTRTPMTNVHGLDIKNNQLVDNIQRIV.WEKKSLISQKE......F.cY.KECILRHATEENYVFVDF....RK..FNSSIKIELVNRVRAKLK.N.............VMAEFKIKYFLGSGSQS..KSSMLHALNHPKS.KPNTTLEIEILSTED....ERPSKEELRDEVFKLSKLLFMG.HPDNIFFYY.qSPKMYPKTIMLKK.QELLTLQLENLYIVGKTD....................................GVTTHVLVDQ....SGIL...CYFKHLGYAIKYKCNKKLTG.VIELVCEAVKnqSNNTWTLYVIKVIKP..SMNDRLSELEFVNEEL.................................
#=GR A0A1B1MRC8_9POXV/27-341  pAS   ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
A0A0K1LDX7_9POXV/27-338             ......qgs---TAYEINNELELVFIKPPLITLTNVV...NI.STIQESFIRFTVTN...-KEGVKIRTKIPLSKVHGLDVKNVQLVDAIDNIV.WEKKSLVTENR......L..H.KECLLRLSTEERHIFLDY....KK..YGSSIRLELVNLIQAKTK.N.............FTIDFKLKYFLGSGAQS..KSSLLHAINHPKS.RPNTSLEIEFTPRDN....ETVPYDELIKELTTLSRHIFMA.SPENVILSP..PINAPINTFMLPK.QDIVGLDLENLYAVTKTD....................................GIPITIRVTS....KGLY...CYFTHLGYIIRYPVKRIIDS.EVVVFGEAVK..-DKNWTVYLIKLIEPvnAISDRLEESKYVESKL.................................
#=GR A0A0K1LDX7_9POXV/27-338  pAS   ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
Q6TVC4_9POXV/22-336                 ......rgs---PADEVHHEVELVLVHPPLATLATAL...RL.ASETESFILFTVTA..lAKEEGKLRARMPLSRVVGLDVKNVQLVNSIDTIV.WERKSLVEETE......L..H.PGCLLRHSTERRHLFVDF....KK..YLSAIRVELVNLVRVRSK.E.............VIADFKFKYFLGSGAQA..KSALLHALNHPKI.RPSATLEFEVVP-SG....ETLDEASVLAELRAMAKALFMA.GSDSVFLTP.aLSAPPVRTVMLQK.QEIPALELEGLYSVSKTD....................................GVLAAVAVTE....DGVR...CSFGHLGYTIRYPLAKAPKC.EYRLWCEAVRpvGERVWAMHVLFVEEP..QGSDRIADAAAAAEA-l................................
#=GR Q6TVC4_9POXV/22-336      pAS   ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
Q070E2_CPRVZ/26-341                 ........e-NRFDAARHNEVELILLNPPLSAVSVLH...TI.ATVEESYVQYVLKA...--KDAKIRNRLSVKDVHGLDVKNYQLVERLDDAN.WERKAPVWEKS......F..-.PGATIKHSTEESHPFTDY....RN..YSGNIKLEFVNLVRARAK.H.............LIVDAKFKYFIGNGSQN..YNSLLYALNDPAA.KPGVTLEFEIDVSREhlerEGFSFAELRASLYTVCQALFLA.PADSVFLVQggGPRPPVPTNMLKK.YQLQTLETADLYVTEKTD....................................GVLTYVLLRD....KDIF...CHFAHLGYFIRYRGRRKFAE.PVSLMGEMTR.aGSGEKVVHFIKLQTP..ALPDRLEERAFVEERL.................................
#=GR Q070E2_CPRVZ/26-341      pAS   ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
A0A1L3IZK0_9POXV/28-337             .....qlpi-----DDIYDEVEAIIINPPLITLTNVF...NI.STKVESYILFTVTN...KEDGLKLRSRLDMSNVNGLDIKNVQLVDSIESII.WEKKKLIYEQK......I..D.EFCIIRHSTEEKYIFLDF....KK..FNSSIKIEFVNLVQAKIK.N.............ILVDFKIKYFLGSGAQG..KSSLLHVLNYPKC.KPNMTLEFEIIQ-KD....TPIDEKELYNELITICRNIFMG.YPKNIFLKR..ECGYPIRTHMLKK.QDINSISLDDLYITNKTD....................................GIGTFISILK....DGIY...CYFSHLNYTIRYDVNKKVDN.PIKLYGEGLK..YDGKWSIYLIKLVTP..EFNDRFKEKEFVTNEL.................................
#=GR A0A1L3IZK0_9POXV/28-337  pAS   ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
MCEL_VACCW/27-338                   .......qr--STAYEINNELELVFIKPPLITLTNVV...NI.STIQESFIRFTVTN...-KEGVKIRTKIPLSKVHGLDVKNVQLVDAIDNIV.WEKKSLVTENR......L..H.KECLLRLSTEERHIFLDY....KK..YGSSIRLELVNLIQAKTK.N.............FTIDFKLKYFLGSGAQS..KSSLLHAINHPKS.RPNTSLEIEFTPRDN....ETVPYDELIKELTTLSRHIFMA.SPENVILSP..PINAPIKTFMLPK.QDIVGLDLENLYAVTKTD....................................GIPITIRVTS....NGLY...CYFTHLGYIIRYPVKRIIDS.EVVVFGEAVK..-DKNWTVYLIKLIEPvnAINDRLEESKYVESKL.................................
#=GR MCEL_VACCW/27-338        SS    .......-----------EEEEEEESS--SHHHHHHH...TT.-SEEEEEEEEEEE-...-SSSEEEEEEEEGGG--SSS--HHHHHHT----E.EEEEEEEEEEE......E..E.TTEEEEEEEEEEEE-TTS....GG..GGGG-EEEEEEEEEEE-S.S.............EEEEEEEEEEEEETT--..S-HHHHHHHSTTS.--EEEEEEEE--SSS....S---HHHHHHHHHHHHHHHHSS.-TTSEEE--..----SSEEEE--G.GGGSS---TTEEEEE--S....................................SEEEEEEEET....TEEE...EEETTTTEEEEE--SS--SS.-EEEEEEEEE..-SSSEEEEEEEEES------SHHHHHHHHHHHT.................................
#=GR MCEL_VACCW/27-338        AS    ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
A0A068ELN3_9POXV/28-343             .......id--KVNESKHHEVELILFKPPIITLTNLY...NM.ATATESYIEFTMLP..vDKPNTKFRNRIPLSKIHGLDVKNNQLVESLDGFI.WEEKSLLLKKD......I.sDnSSAVIRHSVEEKTLFVDY....KR..RNASIKLELVSLVRAKLR.N.............IVIDFKMKYFLGSGAQSanSSSLLCALNHPKN.KPSLYIEFEIMT-QD....KNISKKKLLEELNMSASALFLS.QPKYIRLCP..SINPILRTHLLKK.QDIINLCTEDLYITSKTD....................................GIFSHIYIEK....KSIF...CYFGHLGYIKEYTASRELEE.PIYLYAEMRK..EESILYLTVIKVVKP..CMEDRLSELEFVKNNL.................................
#=GR A0A068ELN3_9POXV/28-343  pAS   ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
Q6TUT6_YMTV5/27-336                 ......plp----TEDVNNEVELVFIRPPLITLGNVL...NI.SSVQESFIMFTVGN...KEKKEKIRTNVPLSKVHGLDIKNVQLVESVNNII.WEKKTLLSEYK......V..N.DNCLIRHSIEEKHVFLDY....KK..YISSIKLELVNLIQAKIK.N.............VKVDFKLKYFLGSGAQA..KSSLLHVLNHPRS.KPSPSLEFEIVN-TD....ININENELFNELHALFRSIFMN.LPENVFLVP..NFKNPLKTYMLKK.QDISGISLDNLYATTKTD....................................GIGAIVKIKQ....NKIY...CHFSHINYCIKYLANRTMEN.EIVIYGEALK..YNGKWNIYLIKLINP..NLENRIMEKDFVDEEL.................................
#=GR Q6TUT6_YMTV5/27-336      pAS   ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
A0A097IVV1_9POXV/39-350             ......phs---PTDDIYDEVEAVIINPPLITLTNVF...NI.STKIESYMLFTVTN...KEDGFKIRSRLNMSNIYGLDIKNVQLIDSIDNII.WEKKKLITEEK......V..D.ENCIIRHSTEEKHIFLDF....KK..YNSSIKIEFVNLIQSKIK.N.............ILVDFKLKYFLGSGAQG..KSSLLHVLNYPKC.KPNMSLEFEILH-KD....KPINETDLYNELVTIYRNIFMG.YPKNIFLKR..QLSYPIHTYMLKK.QDISGISLDDLYITNKTD....................................GVGTYITILD....SGIY...CYFSHLNYTIRYDINKKINTtTVKLYGEGLK..YDGKWSIYLIKLITP..SFDDRFKEKEFVSNEL.................................
#=GR A0A097IVV1_9POXV/39-350  pAS   ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
U3UBK1_9POXV/26-337                 .....epaa-----VDVHHELELVFIRPPLAALGAIV...GL.ATEQTSYVLFTVSS...-RDGVKLRVKLPMSRVHGLDAKNVQLVDAVDDII.WEKKTLVSQRE......L..AgGACLLRHSTEERHIFVDF....KK..FGSSIKLELVNLIRISAR.N.............IVTDFKFKYFLGSGTQA..KSSLLHALNHPKS.RPNATLEFEVLR-RD....ADATAEQLAEELTTVARAIFMA.HPDNVFLVP..PVRDPIRTHMLKK.QNILSLELQGLYATSKTD....................................GVAATVRVDA....SGVY...CFFNHLGYVIRYPALREVEE.PVVLFGEAVRsaEDRRWHVHLIKLVAP..TLESRLEEHEFVERR-m................................
#=GR U3UBK1_9POXV/26-337      pAS   ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
R4ZEP7_9POXV/20-347                 ........k-FDTSKNVNNEVELTYINPDLMLLSNIFt.dNN.ESKKKTYLEYNLKF...INKNSKLRQIHKY-NYSTFEIANSYFLDKLTN-N.WENKTVLSEEKi....dI.nKqEHILLRHNIEYQ------....--..-DDEVKLPLLNDLLDKIN.VifvshvyiiinsiIRVEFKIKSNIGPLSSN..KLLLSTHFNDIDTyRKNISYYLEIEVLPQ....AKVDSKILYENLIKAFEYVYKSkNISNISILK.tKEIPKIKTHMIQY.NKLNTIDKDSYILAVKIDgdvvefnvkngicnitiynniyknftcnidkniqmrGLGEYIKVNN...iKKIY..pFYFYEISYVDKNNIIDR---.----------..---------------..----------------yeqiqfynnnl......................
#=GR R4ZEP7_9POXV/20-347      pAS   ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
D3IZL1_9POXV/22-335                 ......rga---PEDEVHHEVELVLVNPPLSTLAATL...RL.ASETESFILFTVTA..lAKEEGKLRARVPMSRVVGLDVKNVQLVNAIDSIV.WERKALVEETA......L..Q.EGCLLRHSTERRHLFVDY....KK..YLSAIRVELVNRVRVRSK.E.............VVADFKFKYFLGSGAQA..KSSLLHALNHPKV.RPAATLEFEVVP-AG....EAVDEAAVLAELRAVAKALFMA.PTDAVFLTP..PADMPVRTLMLQK.QEIPALELEGLFAVSKTD....................................GVSASVRVDA....GGVF...CAFSHLGYTIRYPLAREVKG.VFRLWCEAVRpvGERVWSLFVLFVEEP..AGEDRVAAVAAAVE--al...............................
#=GR D3IZL1_9POXV/22-335      pAS   ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
Q9Q8M4_MYXVL/24-332                 ........n-PVQTDDINHEVELTFIHPPIIALSTLI...HV.ATSQESYILFTVTN...--KGVKIRNRINLSKIHGLDLKNIQLVDSIDNII.WEKKTLVKEHK......V..D.PAAVVKYSTEEKYIFLDY....KK..YLSSIKLELVNVVQAKVK.H.............VTVDFKFKYFLGSGAQA..KSSLLHVLNHPKS.KPNPSLEFEIVT-TD....EKIDSVSLRKELVALFKLVFMT.SPDNIILDG..ILKPPVQTVMLKK.NDLPGIDLTNLYVTTKTD....................................GVGVLITVTN....KGIY...CFFTHLQYTIRYDTTFKSDN.PVTLYGEAIK..QNNVWHVYLIKLMTP..KLSDRFKEKDYVEEHL.................................
#=GR Q9Q8M4_MYXVL/24-332      pAS   ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
Q98257_MCV1/128-443                 .......aa--DTTSDVHHEVELIFVRPPLVTLSHLL...GI.ATRQESYVLFSLTS..lEREGVKLRTRLPLARVHGLDMKNNQLVEAIDSIL.WEKKTRVAQRD......F.pE.AHCLLRHSTEEQYVFLDF....RN..FNSAIRLELVNHVQARVR.N.............IVVDFKLKYFLGSGAQT..RNSLLAVLNYPKF.RPSVTLEFEVLLRDP....AAFSPRELLRELLVLGNLLFMA.PAEHVFLMP..APKEPLTTHMLKK.QDLLTLELRDLYVTGKTD....................................GVPTFVHVAG....ASVY...CFFSHLGYAIRYPARVTLPA.PVALFGEAVRdaQSKQLTVYLIKLMAP..ALEDRLEEREFVLRRL.................................
#=GR Q98257_MCV1/128-443      pAS   ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
A0A1Z3GCT8_9POXV/22-339             .....rglp----DDEVHHEVELVLVSPPLSTLASAL...KL.ASETESFILFTVTS..lAKEDGKLRTRVPLSRVVGLDVKNVQLVNSINSIV.WERKSLVEETE......V..C.PGCLVRHSTERRHLFVDF....KK..YLSAIRVELVNLVRVRSK.E.............VCADFKFKYFLGSGAQS..KSSLLHALNHPKS.RPSPTLEFEVVPYSHs.epRALDEAAVLKELRSMAKALFMA.SAESVFLEI..LPPPPIKTLMLQK.QEIPGMNLEGLYAVSKTD....................................GVPAKVLVHE....SGVY...CAFSHLGYTIRYPVKQPPRC.AYKLWCEAVRpvGERVWSLFVLFVEDQ..EPQDRVSSVA------aavaal...........................
#=GR A0A1Z3GCT8_9POXV/22-339  pAS   ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
Q6VZF5_CNPV/28-341                  ......vse---VDKSKHHEVEMQIFKPSIITLSNLY...NI.STTTESYIEFSMMP..iDKKNTKYRNRIPLSKIHGLDIKNSQLVENLDGFI.WEEKTLISEKR......V.sEcTNIRIRHSVEQKTLFVDY....KR..RNGSIRLELVSVVRATLR.N.............IVVDFKIKYFLGSGAQS..ASSLLYALNNPKN.KPNLYLEFEIST-SD....KNISKQLLLNELNTIGNALFLS.KVDKIRLCP..RIKLVLKTYLLKK.QEIINLNIENLYITSKTD....................................GVFTYVLLQN....KSIY...CYFSHLGYIKEYTANREIDE.KVYLYAEMRK..ENGILYFTVIKVLNP..RMKNRLDELKFVNKNL.................................
#=GR Q6VZF5_CNPV/28-341       pAS   ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
Q0NPA3_9POXV/27-338                 ......qgs---TAYEINNELELVFIKPPLITLTNVV...NI.STIQESFIRFTVTN...-KEGVKIRTKIPLSKVHGLDVKNVQLVDAIDNIV.WEKKSLVTENR......L..H.KECLLRLSTEERHIFLDY....KK..YGSSIRLELVNLIQAKTK.N.............FTIDFKLKYFLGSGAQS..KSSLLHAINHPKS.RPNTSLEIEFTPRNN....ETVPYDELIKELTTLSRHIFMA.SPENVILSP..PINAPINTFMLPK.QDIVGLDLENLYAVTKTD....................................GIPITIRVTS....KGLY...CYFTHLGYIIRYPVKRIIDS.EVVVFGEAVK..-DKNWTVYLIKLIEPvnAISDRLEESKYVESKL.................................
#=GR Q0NPA3_9POXV/27-338      pAS   ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
Q8JJP2_LSDVN/26-337                 ......npt---LSNDVNHEVELVFIQPPIITLSNVY...NI.SSVTESYILFTVTN...KGECIKIRTKVPMSKIHGLDLKNLQLVDLIDDII.WEKKTLIKEKK......I..D.KHCIIRYSSEERHVFLDY....KR..YTSSIKLELVNLVQTKVK.N.............IVVDFKIKYFLGSGAQA..KSSLLHVLNHPKS.KPTPTLEFEIIT-RE....KKNSRDTLLDELHILFKNIFMA.DPKNVFLPT.vIFTSPVKTIMLKK.QEIHNIELDKLYITTKTD....................................GVGTLIKINK....NGIF...CYFTHLNYIIKYNLLRKFND.TVILYGEAIK..QNQKWFIYLIKLLKP..ELSNRFKERDFLIEKL.................................
#=GR Q8JJP2_LSDVN/26-337      pAS   ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
Q8V3L9_SWPV1/26-336                 .......qp--VHLDDVNHEVEMIFTNPSIVTLSNLI...NI.SSTQESYILFTLTR...KDEHTKIRTKIPMSKIHGIDIKNIQLVNCIDNII.WEKKIRVKENI......I..D.DWCIVQYSTEEKYIFLDY....KK..FTSSIKLELVNLIQARIK.N.............IVIDFKIKYFLGSGAQS..KSSLLHVLNHPKS.KPKTSLEIEIVT-RD....IKIDTSVLSNEIHTICKILFMS.DTKNIYLYS..RFKNPIKTHMLKK.QDITSIDLENLYITTKTD....................................GVGVLVKINK....NGIY...CYFQHLMYTIRYTLIKVLDN.DVTIYGEAIK..QNNVWNIYLIKMIQP..VLVDRFNERDYVVSYL.................................
#=GR Q8V3L9_SWPV1/26-336      pAS   ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
W6JL07_9POXV/21-375                 ......yid----DDKLHNEVEITYLFPNLILLSNLY...QYdECKKTTYLEFSLSYt.dNKKRIKFRQIVPYTTQDKFEIKNSYLANKLFNVNkLDIKSEISNKNillnesN..K.EKIIFRHSTEKKIIDSDItlpsKQelLKNQVRLTFVNSIRIMID.N............lIKIEFKYKANLGSASSN..SLALSTYLNNIDTaRILTTYYLEIELLSN....TKIDNDILINVLNKSFGYIFSIrNLDNFSLSI.sNEYVPIKTFMITY.DKLHIIDKSAYVMTPKIN....................................GESVSFYVENgicnITIY..nFIYKNINCNINKNVIMSGEG.ELII-IDNIK..HIFPFYFNLIKDNKI..SYTDRYKQIEFYNT--siinfksnmkihfrnknifkfe...........
#=GR W6JL07_9POXV/21-375      pAS   ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
A0A0A7M9R9_9POXV/30-343             .....rgpa----EDEVHHEVELVLVNPPLSTLAVAL...RL.ASETESFILFTVTA..lAKEEGKLRARMPLSRVVGLDVKNVQLVNAIDSIV.WERKALVEETE......L..R.AECLLRHSTERRHLFVDF....KK..YMSAIRVELVNRVRVRSR.E.............VQADFKFKYFLGSGAQS..KSSLLHALNHPKM.RPSPTLEFEVVP-SE....AAVDEAAVLAELRAMAKALFMA.PAEAVFLEP..PPRMPVKTHMLPK.QEIPSLDLQGLYAVSKTD....................................GVPAAVTVDE....SGVY...CAFAHLGYTIRYAAARAPAK.QYRLRCEAVRhvGERVWSMYIILVEEP..AGVDRVAAAEAAAEE-l................................
#=GR A0A0A7M9R9_9POXV/30-343  pAS   ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
Q9YW26_MSEPV/18-376                 .....thnp----VDNVHNEIELTYLFDNLLLLSNIA..sYT.ETKKKLQLEYIIKY...VDKSIKLRQRHEY-DYPNFEITNTYMIQKLTN-Q.WTIKKLINKIEe....nI.gN.EKFIIAHNTEEDNIKNNMiippKK.lIMSNVTIHILSSIYFIINgN.............VRVEFKLKGTLGAADNN..KMMLQTYLNNVLTyKQFTSYYIEIEI--L....NKLSKDEFYRDITNAFRYIYSInNLNNFALST.kNISPSVKTFMLPF.DSLYLMDKSKYFLTSKIDgevvqftvkngicdivlynfifknkqtnipnhivmkGFGEYKKIDN...vKTIY..pFVFTEIYSTDSKQKYNTRYE.MIKFYNDNIK..NKEFDITFKHKPIIP..IEKDIV----------neaiayyksl.......................
#=GR Q9YW26_MSEPV/18-376      pAS   ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
Q9EMR4_AMEPV/20-336                 .........NFDSNPNVNNEIEFTYINPDLRILSNIYt.dNN.ESKKKTYLEYVLKF...ANKKSKLRQKYKY-DYPTFEIANSYFLDKLTN-N.WERKTIISEDKi....nI.nKnEYILLRHNTEYQ------....--..-DNDIELPLLNDILDKIN.VlfvsqlyiiindlIKVEFKIKSNIGPLSSN..KLLLSTHFNDIETyRKNITYYLEIEVLSK....TKLDNNVLYDNLVKSFEYIYKSkNISNISLVT.iKNKPKIKTHMIQY.NKLNTIDKESYIMAIKIDgdvvefnvmngicniiiydmvyknfscnidkniqmiGMGEYIKVDN...vKKIY..pFYFSKLSYNNK---------.----------..---------------..----------------kiinni...........................
#=GR Q9EMR4_AMEPV/20-336      pAS   ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
R4ZFB3_CBEPV/20-341                 .......nl--DNNPNINNEVELTYINPDLMLLSNIFt.dNN.ESKKRTYLEYNLRF...TNKKSKLRQRHKY-DYPTFEIANSYFLDNLTN-N.WEKKTIIYEEKi....dI.nKnEHILLRHNTEYQ------....--..-DNDIELPLLKDILDKIN.VifvsqvyiiinniIRVEFKIKSNIGPLASN..KLLLSTHFNDMETyRKNISYYMEIEILSN....IKLDNTTLRDNLIKAFEYIYKSkNISNLSLVT.iKNSPKLKTHMIQY.NKLNIIDKDAYIMTVKIDgdvvefnvkngicniiiyniiyknftcnidkniqmrGLGEYIKVNN...iRKIY..pFYFFELSYTNK-KIITN---.----------..---------------..----------------isdryq...........................
#=GR R4ZFB3_CBEPV/20-341      pAS   ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
A9J1T1_VACCA/27-338                 .......qr--STAYEINNELELVFIKPPLITLTNVV...NI.STIQESFIRFTVTN...-KEGVKIRTKIPLSKVHGLDVKNVQLVDAIDNIV.WEKKSLVTENR......L..H.KECLLRLSTEERHIFLDY....KK..YGSSIRLELVNLIQAKTK.N.............FTIDFKLKYFLGSGAQS..KSSLLHAINHPKS.RPNTSLEIEFTPRDN....EKVPYDELIKELTTLSRHIFMA.SPENVILSP..PINAPIKTFMLPK.QDIVGLDLENLYAVTKTD....................................GIPITIRVTS....KGLY...CYFTHLGYIIRYPVKRIIDS.EVVVFGEAVK..-DKNWTVYLIKLIEPvnAISDRLEESKYVESKL.................................
#=GR A9J1T1_VACCA/27-338      pAS   ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
A0A0M3ZRQ5_9POXV/27-342             .......na--EIDDSKHHEIELILFKPPIITLTNLY...YI.ASSMESYIEFTMLP..iNKPNTKFRNRMSLSKIHGLDVKNNQLVENIDNII.WEQKTLIKKKD......I.aDnSSCVIRYSIEEKTLFVDY....KK..YNSSIKLELVNLIRTRLR.N.............IVIDFKMKYFLGSGAQSasSSSLLCALNHPKN.KPSLILEFEIMI-QD....KTVTRNMLLDELCMVANALFLS.EPRHVRLCP..YLQPKLKTYLLKK.QELINIDTDNLYITGKTD....................................GIFSYVYIYH....RSIF...CYFNHLGYIKDYDISVDVEE.PIYLYAEMRK..ENNIIYFTVIKVLLP..ELDDRLAELEFVNSNL.................................
#=GR A0A0M3ZRQ5_9POXV/27-342  pAS   ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
Q6TVQ6_ORFSA/22-335                 ......rga---PEDEVHHEVELVLVDPPLSTLAATL...RL.ASETESFILFTVTA..lAKEEGKLRARVPMSRVVGLDVKNVQLVNAIDSIV.WERKALVEETA......L..Q.EGCLLRHSTERRHLFVDY....KK..YLSAIRVELVNRVRVRSK.E.............VVVDFKFKYFLGSGAQA..KSSLLHALNHPKV.RPSPTLEFEVVP-AG....EAVDEAAVLTELRAVAKALFMA.PTDAVFLLP..PAEMPVRTLMLQK.QEIPALDLDGLFAVSKTD....................................GVSASVRVDE....NGVF...CAFSHLAYTIRYPLAREVQG.RYRLWCEAVRpvGERVWSMFVLVVEEP..AGDDRVAAVAGAVEA-l................................
#=GR Q6TVQ6_ORFSA/22-335      pAS   ...................................................................................................................................................................................................................................................................................................*..............................................................................................................................................................
#=GC SS_cons                        .......-----------EEEEEEESS--SHHHHHHH...TT.-SEEEEEEEEEEE-...-SSSEEEEEEEEGGG--SSS--HHHHHHT----E.EEEEEEEEEEE......E..E.TTEEEEEEEEEEEE-TTS....GG..GGGG-EEEEEEEEEEE-S.S.............EEEEEEEEEEEEETT--..S-HHHHHHHSTTS.--EEEEEEEE--SSS....S---HHHHHHHHHHHHHHHHSS.-TTSEEE--..----SSEEEE--G.GGGSS---TTEEEEE--S....................................SEEEEEEEET....TEEE...EEETTTTEEEEE--SS--SS.-EEEEEEEEE..-SSSEEEEEEEEES------SHHHHHHHHHHHT.................................
#=GC seq_cons                       ........t...ssp-lppElELlalpPPLITLoNlh...Nl.uoppESaIhFTVTs...tccssKlRs+lPhS+lHGLDlKNsQLV-uIDNIl.WE+KoLlpEpc......l..c.cpCllRaSTEE+alFlDa....KK..YsSuI+LELVNllps+hK.N.............lslDFKlKYFLGSGAQu..KSSLLHsLNHPKo.+PNsoLEhElhs.ss....cplspspLhpELpsls+tlFMu.ss-NlhLss...hpsPl+TaMLpK.Q-Isul-L-sLYhsoKTD....................................Glsshl+lss....pGIY...CYFoHLuYhIRYssp+plcs.plhlauEAlK..tpp.WtlalIKllpP..shsDRlpEtcalpppL.................................
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