GenomeNet

Database: Pfam
Entry: Pox_ATPase-GT
LinkDB: Pox_ATPase-GT
Original site: Pox_ATPase-GT 
#=GF ID   Pox_ATPase-GT
#=GF AC   PF10640.12
#=GF DE   mRNA capping enzyme N-terminal, ATPase and guanylyltransferase
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   Karlin D
#=GF GA   25.00 25.00;
#=GF TC   29.70 100.80;
#=GF NC   20.90 20.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0273
#=GF RN   [1]
#=GF RM   8227060
#=GF RT   Identification of the vaccinia virus mRNA guanyltransferase
#=GF RT   active site lysine. 
#=GF RA   Niles EG, Christen L; 
#=GF RL   J Biol Chem. 1993;268:24986-24989.
#=GF RN   [2]
#=GF RM   8662635
#=GF RT   Domain structure of the vaccinia virus mRNA capping enzyme.
#=GF RT   Expression in Escherichia coli of a subdomain possessing the RNA
#=GF RT   5'-triphosphatase and guanylyltransferase activities and a
#=GF RT   kinetic comparison to the full-size enzyme. 
#=GF RA   Myette JR, Niles EG; 
#=GF RL   J Biol Chem. 1996;271:11936-11944.
#=GF RN   [3]
#=GF RM   17989694
#=GF RT   Structural insights into the mechanism and evolution of the
#=GF RT   vaccinia virus mRNA cap N7 methyl-transferase. 
#=GF RA   De la Pena M, Kyrieleis OJ, Cusack S; 
#=GF RL   EMBO J. 2007;26:4913-4925.
#=GF DR   INTERPRO; IPR019602;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain is the N-terminus of the large subunit viral mRNA
#=GF CC   capping enzyme, and carries both the ATPase and the
#=GF CC   guanylyltransferase activities of the enzyme. The
#=GF CC   guanylyltransferase enzymatic region runs from residues 242
#=GF CC   (leucine)-273(arginine) [1], the core of the acitve site being
#=GF CC   the lysine residue at 260 [2]. The ATPase activity is at the
#=GF CC   very N-terminal part of the domain [3].
#=GF SQ   45
#=GS G3EIG4_9POXV/26-336      AC G3EIG4.1
#=GS Q08FR4_DPV83/26-337      AC Q08FR4.1
#=GS R4JNM0_9POXV/26-340      AC R4JNM0.1
#=GS MCEL_RFVKA/25-333        AC P25950.1
#=GS A0A068EH17_9POXV/28-343  AC A0A068EH17.1
#=GS MCEL_VACCT/27-338        AC Q9JFA8.1
#=GS MCEL_CAMPS/27-338        AC Q775U0.1
#=GS A0A2C9DT55_9POXV/38-356  AC A0A2C9DT55.1
#=GS R4ZFK7_9POXV/20-373      AC R4ZFK7.1
#=GS A0A2U9QHS7_9POXV/27-342  AC A0A2U9QHS7.1
#=GS A0A223FMV0_9POXV/26-336  AC A0A223FMV0.1
#=GS A0A0H4Y1K2_9POXV/20-327  AC A0A0H4Y1K2.1
#=GS MCEL_FOWPN/28-343        AC Q9J584.1
#=GS A0A1B1MRC8_9POXV/27-341  AC A0A1B1MRC8.1
#=GS R4ZF74_9POXV/20-341      AC R4ZF74.1
#=GS Q6TVC4_9POXV/22-336      AC Q6TVC4.1
#=GS Q070E2_CPRVZ/26-341      AC Q070E2.1
#=GS A0A1L3IZK0_9POXV/28-337  AC A0A1L3IZK0.1
#=GS MCEL_CWPXB/27-338        AC Q8QMV9.1
#=GS F1AX59_ORFV/22-335       AC F1AX59.1
#=GS Q3I8R6_MONPV/27-338      AC Q3I8R6.1
#=GS MCEL_VACCW/27-338        AC P04298.1
#=GS MCEL_VACCW/27-338        DR PDB; 4CKB A; 34-338;
#=GS MCEL_VACCW/27-338        DR PDB; 4CKC D; 27-338;
#=GS MCEL_VACCW/27-338        DR PDB; 4CKE D; 27-338;
#=GS MCEL_VACCW/27-338        DR PDB; 6RIE O; 27-338;
#=GS MCEL_VACCW/27-338        DR PDB; 4CKE A; 34-338;
#=GS MCEL_VACCW/27-338        DR PDB; 4CKC A; 27-338;
#=GS MCEL_VACCW/27-338        DR PDB; 4CKB D; 27-338;
#=GS A0A068ELN3_9POXV/28-343  AC A0A068ELN3.1
#=GS Q6TUT6_YMTV5/27-336      AC Q6TUT6.1
#=GS A0A097IVV1_9POXV/39-350  AC A0A097IVV1.1
#=GS U3UBK1_9POXV/26-337      AC U3UBK1.1
#=GS A0A6B9R1L8_9POXV/27-340  AC A0A6B9R1L8.1
#=GS R4ZEP7_9POXV/20-347      AC R4ZEP7.1
#=GS D3IZL1_9POXV/22-335      AC D3IZL1.1
#=GS Q9Q8M4_MYXVL/24-332      AC Q9Q8M4.1
#=GS Q98257_MCV1/128-443      AC Q98257.1
#=GS A0A3F2YKN2_SHEVT/26-337  AC A0A3F2YKN2.1
#=GS Q6VZF5_CNPV/28-341       AC Q6VZF5.1
#=GS MCEL_VAR67/27-338        AC P0DSX5.1
#=GS Q0NPA3_9POXV/27-338      AC Q0NPA3.1
#=GS Q9DHN4_YLDV/26-336       AC Q9DHN4.1
#=GS Q8V3L9_SWPV1/26-336      AC Q8V3L9.1
#=GS A0A1V0S7Z3_CNPV/28-343   AC A0A1V0S7Z3.1
#=GS W6JL07_9POXV/21-375      AC W6JL07.1
#=GS Q9YW26_MSEPV/18-376      AC Q9YW26.1
#=GS Q9EMR4_AMEPV/20-336      AC Q9EMR4.1
#=GS A0A3S7SVX5_9POXV/26-337  AC A0A3S7SVX5.1
#=GS A0A0M3ZRQ5_9POXV/27-342  AC A0A0M3ZRQ5.1
#=GS Q6TVQ6_ORFSA/22-335      AC Q6TVQ6.1
#=GS MCEL_VARV/27-338         AC P0DSX6.1
G3EIG4_9POXV/26-336                 ........n-QSATYDVNNELELIFTNPPLITLTNVF...NI.STLQESFIRFTVTN...-KDGVKIRTKIPLSKVHGLDIKNSQLVDVIENIV.WEKKTLINEIV......Y..N..KEVILRLSTEEKYIFLDY....KK..YGSSIKLELVNLIQSRTK.N.............FIIDFKIKYFLGSGAQ..S..KCSLLHSINHPKS.KPNMSLEIEFISMDN....KNVQYDKLLNELTTISRNIFMA.SPENVYLSP..IIKIPVNTFMLHK.QDIPALELENLYAVSKTD....................................GIPVTVKLKS....TGIY...CYFGHIGYIIRYPIKKNLD.T.DIILFGEAIK..DKNQWIIYLIKLLEP..VIHDRLDERNYIESRL.................................
Q08FR4_DPV83/26-337                 ........k-PKSLDDINHEVEIVFIQPPLITLNNVL...NI.SSKQESYILFSLTN...KEDRVKIRSYLPMSKVYGLDLKNIQLVDSIDNII.WEKKTLITEHI......V..D..KHCMVRYSTEEKHIFLDY....RK..YISAIRLELVNLIQLKIK.N.............ILIDFKIKYFLGSGAQ..A..KSSLLHVLNHPKS.KPNVSLEFEIISEND....YKIDKDIIFNEISTLFRNIFMG.NPKNIFMTP..EQKNPIKTRMIKK.QDLTGLELDNLYITTKTD....................................GVGSLIKINK....NGIF...CYFSHLNYSIRYNLLKPID.K.QIVLYGEALK..HGKMWNIFLIKLIEP..ILDDRIKEKDFINDEL.................................
R4JNM0_9POXV/26-340                 .....kppl----KDDINHEFEIIFIDPPLIALSNIY...KI.STKHESFILFTVTD...KENSVKYRTTIPLSNIHGLDIKNVQLVESINNIV.WEKKTLISENK......L..S..SKCILKHSTEERHIFLDF....IK..YISAIKLELVNLIQVRAK.N.............FNIDFKFKYFLGSGAQ..S..KSSLLHVLNHPKS.KPNPTIEFEYVYNDI...gEKPSKKLLQNELKTLFRSVFMA.LPENIFIPQ.qILHMPIKTIMLKK.QDIINLDVEDLYATTKTD....................................GVPTIVNIIN....NNIY...CYFSHLNYIIKYESIHNFD.K.SITLFGEAIK.nSNKQWIIYLIKLLTP..TFNTRFEEKEFIDKTL.................................
MCEL_RFVKA/25-333                   ........n-PVQTDDMNHEVELTFIQPPVITLSTLL...PF.ATSQESYILFTVTN...--KGVKIRNRINLSKIHGLDLKNIQLVDSIDNII.WEKKTLVKEHK......I..D..SVALVKYSTEEKYIFLDY....KK..YLSAIKLELVNVVQVKVK.H.............VTVDFKFKYFLGSGAQ..A..KSSLLHVLNHPKS.KPNPSLEFEIIT-TD....EKIDSASLRKELIALFKLVFMA.SPSNIILDV..VFKNPVQTILLKK.NELPGIDLTNLYVTTKTD....................................GVGVLITVTN....KGIY...CFFTHLQYTIRYDTTFESN.E.SVTLYGEAVK..QNNVWQIYLIKLITP..KVSDRFKEKEYVEERL.................................
A0A068EH17_9POXV/28-343             .......id--KVNESKHHEVELILFKPPIITLTNLY...NI.ATATESYIEFTMLP..vDKPNTKFRNRIPLSKIHGLDVKNNQLVESLDGFI.WEEKSLLLKKD......I.sD.nSSAVIRHSVEEKTLFVDY....KR..RNASIKLELVSLVRAKLR.N.............IVIDFKMKYFLGSGAQ..SanSSSLLCALNHPKN.KPSLYIEFEIMT-QD....KNISKKKLLEELNMSASALFLS.QPKYIRLCP..SINPILRTYLLKK.QDIINLCTEDLYITSKTD....................................GIFSYIYIEK....KSIF...CYFGHLGYIKEYTASREVE.E.AIYLYAEMRK..EESILYLTVIKVVKP..CMEDRLSELEFVKNNL.................................
MCEL_VACCT/27-338                   .......qr--STAYEINNELELVFIKPPLITLTNVV...NI.STIQESFIRFTVTN...-KEGVKIRTKIPLSKVHGLDVKNVQLVDAIDNIV.WEKKSLVTENR......L..H..KECLLRLSTEERHIFLDY....KK..YGSSIRLELVNLIQAKTK.N.............FTIDFKLKYFLGSGAQ..S..KSSLLHAINHPKS.RPNTSLEIEFTPRDN....EKVPYDELIKELTTLSRHIFMA.SPENVILSP..PINAPIKTFMLPK.QDIVGLDLENLYAVTKTD....................................GIPITIRVTS....NGLY...CYFTHLGYIIRYPVKRIID.S.EVVVFGEAVK..-DKNWTVYLIKLIEPvnAINDRLEESKYVESKL.................................
MCEL_CAMPS/27-338                   ......qgs---TAYEINNELELVFIKPPLITLTNVV...NI.STIQESFIRFTVTN...-KEGVKIRTKIPLSKVHGLDVKNVQLVDAIDNIV.WEKKSLVTENR......L..H..KECLLRLSTEERHIFLDY....KK..YGSSIRLELVNLIQAKTK.N.............FTIDFKLKYFLGSGAQ..S..KSSLLHAINHPKS.RPNTSLEIEFTPRDN....ETVPYDELIKELTTLSRHIFMA.SPENVILSP..PINAPINTFMLPK.QDIVGLDLENLYAVTKTD....................................GIPITIRVTS....KGLY...CYFTHLGYIIRYPVKRIID.S.EVVVFGEAVK..-DKNWTVYLIKLIEPvnAISDRLEESKYVESKL.................................
A0A2C9DT55_9POXV/38-356             ...edarvp------APHHEVELILIKPPIATLSALH...SI.ATHMESYILFTMSP...VDKEVKLRNRIPLSKVHGLDVKNNQLVDSIDSIV.WEKKSLISQTD......Y.eE..ASCMIKHSTEEKMLFVDY....KK..YSSSIKLELVNLVQSRVK.N.............VVVDFKMKYFLGSGSQvaN..SSSILCALNHPKY.KPSTTLEFEILMRDEd..iPHASKSLLLDELMTIGNVLFMA.RADNVFFVP..VPKPPVTTHLVRK.QDVLALEIEHLYLTEKTD....................................GVATFVYANG....SDLY...CYFSHLGYVIRYDTKRVLE.E.PIYLFGEMVRpvGAGMVTVSVIKLIQP..EVGDRLAGAEFADDT-m................................
R4ZFK7_9POXV/20-373                 .......kl--DTNENIKNEVELTLINPDLMLLSNIYt.eNN.ESKKKTYLEYNLKF...SKKKSKLRQRHEY-DYSTYEIPNSHLTDRLTN-N.WETKTVIDEEKi....dI.nK.hEHVLMRHNIEYI------....--..-DNNIELPLINDIFDRIS.VifvsqvyiiidsvLKIEFKIKSYIGPLSS..N..KLSLSTHFNDIDTsRKNISYYLEIEILPN....IKLENNILQEKLEKAFSYIYKStNISNLSLVT.iKEPSRIKTFTIQY.NKLNTIDKDSYVMAIKIDgnvvnftvknsicsviiynviyknykcnidknieikGMGEYIKVNN...vKKIY..pFYFTEIKYVNR-KATNIIE.N.RY--------..---------------..----------------dqiqfynsiitsfkepmqikfenkltlkfnenn
A0A2U9QHS7_9POXV/27-342             ........y--DHKNDTHHELELVFIKPPLVTLANIY...NI.ATLTDSYIQLTATM..lTKEGVKIRTRIPLSNIHGLDIKNTQLIDNLTNII.WEKKSVILQKE......F.aK..GMCILRHSIEERHVFSDF....KN..YSSSIKLEMVNRIRVNIR.N.............IMAEYKIKYFIGSGSQ..A..KSSLLHALNHPKS.KPNMTMEIEILSTES....YRPRRDEISDELSKLMRLIFMG.QPNNVFLYS.pYPKMIPNTIMLKK.QDITTLDLDELYIVGKTD....................................GVQVNIVIEH....TNIY...CFFNHLGYGIRYVCNVKKH.T.TIELVGEAVKnpDENIWTIYVIKVISP..CLSSRLDELDYVSKEL.................................
A0A223FMV0_9POXV/26-336             .......qk--STAYEVNNELELVFTNPPLITLTNVV...NI.STAQESFIRFTVTN...-KEGTKIRTKIPLSKVHGLDIKNSQLVDLVENIV.WEKKTLIKETK......L..H..KEVVLRLSTEERHIFLDY....KK..YGSSIKLELVNLIQSRTK.N.............FVIDFKLKYFLGSGAQ..A..KCSLLHSINHPKS.KPNISLEFEFISRDN....EKVPYDELLSELNTISRNIFMA.SPENVFLSP..IMKIPVNTYMLHK.QDIPGLELENLYAVTKTD....................................GIPVTVKINS....TGIY...CYFTHIGYIIRYPAKKILD.T.TVVLFGEAIK..DKNQWSIYLIKLLEP..VINDRLEERSYIESKL.................................
A0A0H4Y1K2_9POXV/20-327             resnmdlei---------TELEFTQFDPSLLSLSKMFsnpNI.KPLTDSYLEYILNKtsdEGNNIKIRIRIDFAVVGGLELNNKQLLDYVEHGC.WESKETKD-IW......LspD..EFGRITSATEKQGTYINK....VI..QSGKINMIFVNRARVKFS.D.............FVVDFKLKRKLGNCRQ..G.nISNLYKSVNNAMY.PPNPSLEIEHTG--Q....FKKPWKDVKLEFTKVISWIIGH.PIEEILTTT.tPLFKIIPTSVITPaYLMNSIDPTQHKLTPKIN....................................GVGVMFKIDK....KHVLvqqMLGPKVISIWRYKHLLTVT.E.DIYGSGEFIF..---------------..----------------dsdhskciypymilgh.................
MCEL_FOWPN/28-343                   ........i-NKVDESKHHEVELILFKPPIITLTNLY...NM.ATTTESYIEFTMLP..vDKPNTKFRNRIPLSKIHGLDVKNNQLVESLDGFI.WEEKSLLLKKD......I.sD.nSSAIIKYSIEEKTLFVDY....KR..RNASIKLELVSVVRAKLR.N.............IVIDFKMKYFLGSGAQ..SanSSSLLCALNHPKN.KPSLYIEFEIMM-QD....KNISKKKLLEELNMSASALFLS.HPKYIRLCP..SINPILRTHLLKK.QDIININTDDLYITSKTD....................................GIFSHVYIEK....KSIF...CYFSHLGYIKEYTASREIE.E.TIYLYAEMRK..EESILYLTVIKVLKP..CMEDRLSELAFVKNHL.................................
A0A1B1MRC8_9POXV/27-341             .......hn---PKEDKHHELELVFIHPPLITLSNIL...NI.STLVDSYVQFTVTM...SEDNSKIRTRTPMTNVHGLDIKNNQLVDNIQRIV.WEKKSLISQKE......F.cY..KECILRHATEENYVFVDF....RK..FNSSIKIELVNRVRAKLK.N.............VMAEFKIKYFLGSGSQ..S..KSSMLHALNHPKS.KPNTTLEIEILSTED....ERPSKEELRDEVFKLSKLLFMG.HPDNIFFYY.qSPKMYPKTIMLKK.QELLTLQLENLYIVGKTD....................................GVTTHVLVDQ....SGIL...CYFKHLGYAIKYKCNKKLT.G.VIELVCEAVKnqSNNTWTLYVIKVIKP..SMNDRLSELEFVNEEL.................................
R4ZF74_9POXV/20-341                 .......nl--DNNPNINNEVELTYINPDLMLLSNIFt.dNN.ESKKRTYLEYNLRF...TNKKSKLRQRHKY-DYPTFEIANSYFLDNLTN-N.WEKKTIIYEEKi....dI.nK.nEHILLRHNTEYQ------....--..-DNDIELPLLKDILDKIN.VifvsqvyiiinniIRVEFKIKSNIGPLAS..N..KLLLSTHFNDMETyRKNISYYMEIEILSN....IKLDNTTLRDNLIKAFEYIYKSkNILNLSLVT.iKNSPKLKTHMVQY.NKLNSIDKDAYIMTIKIDgdvvefnvkngicniiiyniiyknftcnidkniqmrGLGEYIKINN...iRKIY..pFYFFELSYTNK-KIITN--.-.----------..---------------..----------------isdryq...........................
Q6TVC4_9POXV/22-336                 ......rgs---PADEVHHEVELVLVHPPLATLATAL...RL.ASETESFILFTVTA..lAKEEGKLRARMPLSRVVGLDVKNVQLVNSIDTIV.WERKSLVEETE......L..H..PGCLLRHSTERRHLFVDF....KK..YLSAIRVELVNLVRVRSK.E.............VIADFKFKYFLGSGAQ..A..KSALLHALNHPKI.RPSATLEFEVVP-SG....ETLDEASVLAELRAMAKALFMA.GSDSVFLTP.aLSAPPVRTVMLQK.QEIPALELEGLYSVSKTD....................................GVLAAVAVTE....DGVR...CSFGHLGYTIRYPLAKAPK.C.EYRLWCEAVRpvGERVWAMHVLFVEEP..QGSDRIADAAAAAEA-l................................
Q070E2_CPRVZ/26-341                 ........e-NRFDAARHNEVELILLNPPLSAVSVLH...TI.ATVEESYVQYVLKA...--KDAKIRNRLSVKDVHGLDVKNYQLVERLDDAN.WERKAPVWEKS......F..-..PGATIKHSTEESHPFTDY....RN..YSGNIKLEFVNLVRARAK.H.............LIVDAKFKYFIGNGSQ..N..YNSLLYALNDPAA.KPGVTLEFEIDVSREhlerEGFSFAELRASLYTVCQALFLA.PADSVFLVQggGPRPPVPTNMLKK.YQLQTLETADLYVTEKTD....................................GVLTYVLLRD....KDIF...CHFAHLGYFIRYRGRRKFA.E.PVSLMGEMTR.aGSGEKVVHFIKLQTP..ALPDRLEERAFVEERL.................................
A0A1L3IZK0_9POXV/28-337             .....qlpi-----DDIYDEVEAIIINPPLITLTNVF...NI.STKVESYILFTVTN...KEDGLKLRSRLDMSNVNGLDIKNVQLVDSIESII.WEKKKLIYEQK......I..D..EFCIIRHSTEEKYIFLDF....KK..FNSSIKIEFVNLVQAKIK.N.............ILVDFKIKYFLGSGAQ..G..KSSLLHVLNYPKC.KPNMTLEFEIIQ-KD....TPIDEKELYNELITICRNIFMG.YPKNIFLKR..ECGYPIRTHMLKK.QDINSISLDDLYITNKTD....................................GIGTFISILK....DGIY...CYFSHLNYTIRYDVNKKVD.N.PIKLYGEGLK..YDGKWSIYLIKLVTP..EFNDRFKEKEFVTNEL.................................
MCEL_CWPXB/27-338                   ......qgs---TAYEINNELELVFIKPPLITLTNVV...NI.STIQESFIRFTVTN...-KEGVKIRTKIPLSKVHGLDVKNVQLVDAIDNIV.WEKKSLVTENR......L..H..KECLLRLSTEERHIFLDY....KK..YGSSIRLELVNLIQAKTK.N.............FTIDFKLKYFLGSGAQ..S..KSSLLHAINHPKS.RPNTSLEIEFTPRDN....EKVPYDELIKELTTLSRHIFMA.SPENVILSP..PINPPIKTFMLPK.QDIVGLDLENLYAVTKTD....................................GIPITIRVTS....KGLY...CYFTHLGYIIRYPVKRIID.S.EVVVFGEAVK..-DKNWTVYLIKLIEPvnAISDRLEESKYVESKL.................................
F1AX59_ORFV/22-335                  ......rga---PEDEVHHEVELVLVDPPLSTLAATL...RL.ASETESFILFTVTA..lAKEEGKLRARVPMSRVVGLDVKNVQLVNAIDSIV.WERKALVEETA......L..Q..EGCLLRHSTERRHLFVDY....KK..YLSAIRVELVNRVRVRSK.E.............VVADFKFKYFLGSGAQ..A..KSSLLHALNHPKV.RPSPTLEFEVVP-AG....EAVDEAAVLAELRAVAKALFMA.PTDAVFLAP..PAEMPVRTLMLQK.QEIPALDLDGLFAVSKTD....................................GVSASVRVDE....DGVF...CAFSHLAYTIRYPLAREVQ.G.RYRLWCEAVRpvGERVWSMFVLVVEEP..AGDDRVAAVAGAVEA-l................................
Q3I8R6_MONPV/27-338                 .......qr--STAYEINNELELVFIKPPLITLTNVV...NI.STIQESFIRFTVTN...-KEGIKIRTKIPLSKVHGLDVKNVQLVDAIDNIV.WEKKSLVTENR......L..H..KECLLRLSTEERHIFLDY....KK..YGSSIRLELVNLIQAKTK.N.............FTIDFKLKYFLGSGAQ..S..KSSLLHAINHPKS.RPNTSLEIEFTPRDN....ETVPYDELIKELTTLSRHIFMA.SPENVILSP..PINAPIKTFMLPK.QDIVGLDLENLYAVTKTD....................................GIPITIRVTS....KGLY...CYFTHLGYIIRYPVKRTID.S.EVVVFGEAVK..-DKNWTVYLIKLIEPvnAISDRLEESKYVESKL.................................
MCEL_VACCW/27-338                   .......qr--STAYEINNELELVFIKPPLITLTNVV...NI.STIQESFIRFTVTN...-KEGVKIRTKIPLSKVHGLDVKNVQLVDAIDNIV.WEKKSLVTENR......L..H..KECLLRLSTEERHIFLDY....KK..YGSSIRLELVNLIQAKTK.N.............FTIDFKLKYFLGSGAQ..S..KSSLLHAINHPKS.RPNTSLEIEFTPRDN....ETVPYDELIKELTTLSRHIFMA.SPENVILSP..PINAPIKTFMLPK.QDIVGLDLENLYAVTKTD....................................GIPITIRVTS....NGLY...CYFTHLGYIIRYPVKRIID.S.EVVVFGEAVK..-DKNWTVYLIKLIEPvnAINDRLEESKYVESKL.................................
#=GR MCEL_VACCW/27-338        SS    .......-----TTSSEEEEEEEEESS--SHHHHHHH...TT.-SEEEEEEEEEEE-...-SSSEEEEEEEEGGGS-SSS--HHHHHHT---SE.EEEEEEEEEEE......E..E..TTEEEEEEEEEEEE-TTS....GG..GGGG-EEEEEEEEEEE-S.S.............EEEEEEEEEEEEETT-..-..S-HHHHHHHSTTS.--EEEEEEEE--SSS....S---HHHHHHHHHHHHHHHHSS.-TTSEEE--..----SSEEEE--G.GGGSSS--TTEEEEE--S....................................SEEEEEEEET....TEEE...EEETTTTEEEEEEBSS--S.S.-EEEEEEEEE..-SSSEEEEEEEEES------SHHHHHHHHHHHT.................................
A0A068ELN3_9POXV/28-343             .......id--KVNESKHHEVELILFKPPIITLTNLY...NM.ATATESYIEFTMLP..vDKPNTKFRNRIPLSKIHGLDVKNNQLVESLDGFI.WEEKSLLLKKD......I.sD.nSSAVIRHSVEEKTLFVDY....KR..RNASIKLELVSLVRAKLR.N.............IVIDFKMKYFLGSGAQ..SanSSSLLCALNHPKN.KPSLYIEFEIMT-QD....KNISKKKLLEELNMSASALFLS.QPKYIRLCP..SINPILRTHLLKK.QDIINLCTEDLYITSKTD....................................GIFSHIYIEK....KSIF...CYFGHLGYIKEYTASRELE.E.PIYLYAEMRK..EESILYLTVIKVVKP..CMEDRLSELEFVKNNL.................................
Q6TUT6_YMTV5/27-336                 ......plp----TEDVNNEVELVFIRPPLITLGNVL...NI.SSVQESFIMFTVGN...KEKKEKIRTNVPLSKVHGLDIKNVQLVESVNNII.WEKKTLLSEYK......V..N..DNCLIRHSIEEKHVFLDY....KK..YISSIKLELVNLIQAKIK.N.............VKVDFKLKYFLGSGAQ..A..KSSLLHVLNHPRS.KPSPSLEFEIVN-TD....ININENELFNELHALFRSIFMN.LPENVFLVP..NFKNPLKTYMLKK.QDISGISLDNLYATTKTD....................................GIGAIVKIKQ....NKIY...CHFSHINYCIKYLANRTME.N.EIVIYGEALK..YNGKWNIYLIKLINP..NLENRIMEKDFVDEEL.................................
A0A097IVV1_9POXV/39-350             ......phs---PTDDIYDEVEAVIINPPLITLTNVF...NI.STKIESYMLFTVTN...KEDGFKIRSRLNMSNIYGLDIKNVQLIDSIDNII.WEKKKLITEEK......V..D..ENCIIRHSTEEKHIFLDF....KK..YNSSIKIEFVNLIQSKIK.N.............ILVDFKLKYFLGSGAQ..G..KSSLLHVLNYPKC.KPNMSLEFEILH-KD....KPINETDLYNELVTIYRNIFMG.YPKNIFLKR..QLSYPIHTYMLKK.QDISGISLDDLYITNKTD....................................GVGTYITILD....SGIY...CYFSHLNYTIRYDINKKIN.TtTVKLYGEGLK..YDGKWSIYLIKLITP..SFDDRFKEKEFVSNEL.................................
U3UBK1_9POXV/26-337                 .....epaa-----VDVHHELELVFIRPPLAALGAIV...GL.ATEQTSYVLFTVSS...-RDGVKLRVKLPMSRVHGLDAKNVQLVDAVDDII.WEKKTLVSQRE......L..A.gGACLLRHSTEERHIFVDF....KK..FGSSIKLELVNLIRISAR.N.............IVTDFKFKYFLGSGTQ..A..KSSLLHALNHPKS.RPNATLEFEVLR-RD....ADATAEQLAEELTTVARAIFMA.HPDNVFLVP..PVRDPIRTHMLKK.QNILSLELQGLYATSKTD....................................GVAATVRVDA....SGVY...CFFNHLGYVIRYPALREVE.E.PVVLFGEAVRsaEDRRWHVHLIKLVAP..TLESRLEEHEFVERR-m................................
A0A6B9R1L8_9POXV/27-340             .......qa--SSVEDIYNEVELVFINPPLITLTNVF...NI.STTQESFILFTLIK...KNENVKIRTRFPLCKIHGLDIKNVQLVENINNII.WEKKTLISQTD......I.vK..DASILRHSTEERYVFLDY....KK..YSSGIKLELVNLIQVKVK.N.............IIVDFKFKYFLGSGAQ..S..KSSLLHVLNHPKS.RPSSSLEIEICQQDA...hHVFTYESLIEELNIIVRAIFMG.HPENVLLNI..SKTDIIKTHMLRK.QDILGLDVNNLYATSKTD....................................GVPSIIKINK....SGVY...CFFKHLNYTIKYPVKN-FC.N.NIVIYGEAVRhvNDKQWKIYLIKLIEP..VVHDRLEEIKYVEK--i................................
R4ZEP7_9POXV/20-347                 ........k-FDTSKNVNNEVELTYINPDLMLLSNIFt.dNN.ESKKKTYLEYNLKF...INKNSKLRQIHKY-NYSTFEIANSYFLDKLTN-N.WENKTVLSEEKi....dI.nK.qEHILLRHNIEYQ------....--..-DDEVKLPLLNDLLDKIN.VifvshvyiiinsiIRVEFKIKSNIGPLSS..N..KLLLSTHFNDIDTyRKNISYYLEIEVLPQ....AKVDSKILYENLIKAFEYVYKSkNISNISILK.tKEIPKIKTHMIQY.NKLNTIDKDSYILAVKIDgdvvefnvkngicnitiynniyknftcnidkniqmrGLGEYIKVNN...iKKIY..pFYFYEISYVDKNNIIDR--.-.----------..---------------..----------------yeqiqfynnnl......................
D3IZL1_9POXV/22-335                 ......rga---PEDEVHHEVELVLVNPPLSTLAATL...RL.ASETESFILFTVTA..lAKEEGKLRARVPMSRVVGLDVKNVQLVNAIDSIV.WERKALVEETA......L..Q..EGCLLRHSTERRHLFVDY....KK..YLSAIRVELVNRVRVRSK.E.............VVADFKFKYFLGSGAQ..A..KSSLLHALNHPKV.RPAATLEFEVVP-AG....EAVDEAAVLAELRAVAKALFMA.PTDAVFLTP..PADMPVRTLMLQK.QEIPALELEGLFAVSKTD....................................GVSASVRVDA....GGVF...CAFSHLGYTIRYPLAREVK.G.VFRLWCEAVRpvGERVWSLFVLFVEEP..AGEDRVAAVAAAVE--al...............................
Q9Q8M4_MYXVL/24-332                 ........n-PVQTDDINHEVELTFIHPPIIALSTLI...HV.ATSQESYILFTVTN...--KGVKIRNRINLSKIHGLDLKNIQLVDSIDNII.WEKKTLVKEHK......V..D..PAAVVKYSTEEKYIFLDY....KK..YLSSIKLELVNVVQAKVK.H.............VTVDFKFKYFLGSGAQ..A..KSSLLHVLNHPKS.KPNPSLEFEIVT-TD....EKIDSVSLRKELVALFKLVFMT.SPDNIILDG..ILKPPVQTVMLKK.NDLPGIDLTNLYVTTKTD....................................GVGVLITVTN....KGIY...CFFTHLQYTIRYDTTFKSD.N.PVTLYGEAIK..QNNVWHVYLIKLMTP..KLSDRFKEKDYVEEHL.................................
Q98257_MCV1/128-443                 .......aa--DTTSDVHHEVELIFVRPPLVTLSHLL...GI.ATRQESYVLFSLTS..lEREGVKLRTRLPLARVHGLDMKNNQLVEAIDSIL.WEKKTRVAQRD......F.pE..AHCLLRHSTEEQYVFLDF....RN..FNSAIRLELVNHVQARVR.N.............IVVDFKLKYFLGSGAQ..T..RNSLLAVLNYPKF.RPSVTLEFEVLLRDP....AAFSPRELLRELLVLGNLLFMA.PAEHVFLMP..APKEPLTTHMLKK.QDLLTLELRDLYVTGKTD....................................GVPTFVHVAG....ASVY...CFFSHLGYAIRYPARVTLP.A.PVALFGEAVRdaQSKQLTVYLIKLMAP..ALEDRLEEREFVLRRL.................................
A0A3F2YKN2_SHEVT/26-337             .....npil----SNDVNHEVELVFIQPPIITLSNVY...NI.SSVTESYILFTVTN...KGECIKIRTKVPMSKIHGLDLKNLQLVDLIDDII.WEKKTLIKEKK......I..D..KHCIIRYSSEERHVFLDY....KR..YTSSIKLELVNLVQTKVK.N.............IVVDFKIKYFLGSGAQ..A..KSSLLHVLNHPKS.KPTPTLEFEIIT-RE....KKNSSDMLLNELHILFKNIFMA.DPKNVFLPT.vIFTSPVKTIMLKK.QEIHNIELDKLYITTKTD....................................GVGTLIKINK....NGIF...CYFTHLNYIIKYNLSRKFD.D.TVILYGEAIK..QNQKWFIYLIKLLKP..ELSNRFKERDFLIEKL.................................
Q6VZF5_CNPV/28-341                  ......vse---VDKSKHHEVEMQIFKPSIITLSNLY...NI.STTTESYIEFSMMP..iDKKNTKYRNRIPLSKIHGLDIKNSQLVENLDGFI.WEEKTLISEKR......V.sE.cTNIRIRHSVEQKTLFVDY....KR..RNGSIRLELVSVVRATLR.N.............IVVDFKIKYFLGSGAQ..S..ASSLLYALNNPKN.KPNLYLEFEIST-SD....KNISKQLLLNELNTIGNALFLS.KVDKIRLCP..RIKLVLKTYLLKK.QEIINLNIENLYITSKTD....................................GVFTYVLLQN....KSIY...CYFSHLGYIKEYTANREID.E.KVYLYAEMRK..ENGILYFTVIKVLNP..RMKNRLDELKFVNKNL.................................
MCEL_VAR67/27-338                   ......qgs---TAYEINNELELVFIKPPLITLTNVV...NI.STIQESFIRFTVTN...-KEGVKIRTKIPLSKVHGLDVKNVQLVDAIDNIV.WEKKSLVTENR......L..H..KACLLRLSTEERHIFLDY....KK..YGSSIRLELVNLIQAKTK.N.............FTIDFKLKYFLGSGAQ..S..KSSLLHAINHPKS.RPNTSLEIEFTPRDN....ETVPYDELIKELTTFSRHIFMA.SPENVILSP..PINAPIKTFMLPK.QDIVGMDLENLYAVTKTD....................................GIPITIRVTS....KGLY...CYFTHLGYIIRYPVKRIID.S.EVVVFGEAVK..-DKNWTVYLIKLIEPvnAISDRLEESKYVESKL.................................
Q0NPA3_9POXV/27-338                 ......qgs---TAYEINNELELVFIKPPLITLTNVV...NI.STIQESFIRFTVTN...-KEGVKIRTKIPLSKVHGLDVKNVQLVDAIDNIV.WEKKSLVTENR......L..H..KECLLRLSTEERHIFLDY....KK..YGSSIRLELVNLIQAKTK.N.............FTIDFKLKYFLGSGAQ..S..KSSLLHAINHPKS.RPNTSLEIEFTPRNN....ETVPYDELIKELTTLSRHIFMA.SPENVILSP..PINAPINTFMLPK.QDIVGLDLENLYAVTKTD....................................GIPITIRVTS....KGLY...CYFTHLGYIIRYPVKRIID.S.EVVVFGEAVK..-DKNWTVYLIKLIEPvnAISDRLEESKYVESKL.................................
Q9DHN4_YLDV/26-336                  ......npl---PTEDVNNEVELIFIQPPLITLGNLL...NI.SSVQESFIMFTVGN...KGKKVKIRTKVPLSKVHGLDIKNIQLVDSVDNII.WEKKTLVYEDV......I..N..DYCLIRHSTEEKHVFLDY....KK..YISSIKLELVNLIQTRIK.H.............IQVDFKLKYFLGSGAQ..A..KSSLLHVLNHPKS.KPTPSLEFEIVN-TD....IKIDENELLNEMYTLFRSIFMN.LPENVFLVP..SFKNPLKTYMLKK.QDIAGLHLENLYATTKTD....................................GIGTIVKIKQ....NEIY...CHFSHINYCIKYLANRTIE.N.EILLYGEALK..HKGKWSIYLIKLMKP..KLENRIKEKDFVDENL.................................
Q8V3L9_SWPV1/26-336                 .......qp--VHLDDVNHEVEMIFTNPSIVTLSNLI...NI.SSTQESYILFTLTR...KDEHTKIRTKIPMSKIHGIDIKNIQLVNCIDNII.WEKKIRVKENI......I..D..DWCIVQYSTEEKYIFLDY....KK..FTSSIKLELVNLIQARIK.N.............IVIDFKIKYFLGSGAQ..S..KSSLLHVLNHPKS.KPKTSLEIEIVT-RD....IKIDTSVLSNEIHTICKILFMS.DTKNIYLYS..RFKNPIKTHMLKK.QDITSIDLENLYITTKTD....................................GVGVLVKINK....NGIY...CYFQHLMYTIRYTLIKVLD.N.DVTIYGEAIK..QNNVWNIYLIKMIQP..VLVDRFNERDYVVSYL.................................
A0A1V0S7Z3_CNPV/28-343              ......vse---VDTSKHHEVEMQILKPSIITLNNLY...DM.ATTTESYVEFTMIP..iDKKNTKYRNRIPLSRIHGLDIKNSQLVENLDGFI.WEEKTLIYEKK......L.sEcsSNIKIRHSIEQKTLFVDY....KR..RNGSIRLELVSVVRAVLR.N.............IVIDFKIKYFLGSGAQ..S..ASSLLYALNNPKN.KPNLYLEFEIST-SD....KNISKQTLLKELNTAGNALFLS.SVDKIRLCP..RIKLVLQTHLIKK.QEIINLNTDNLYVTSKTD....................................GVFTYVLIKD....KSIF...CYFSHLGYIKEYTANRKLEiD.EVYLYAEMRK..DDNILYFIVIKVLTP..EIEDRLDELKFVNDNL.................................
W6JL07_9POXV/21-375                 ......yid----DDKLHNEVEITYLFPNLILLSNLY...QYdECKKTTYLEFSLSYt.dNKKRIKFRQIVPYTTQDKFEIKNSYLANKLFNVNkLDIKSEISNKNillnesN..K..EKIIFRHSTEKKIIDSDItlpsKQelLKNQVRLTFVNSIRIMID.N............lIKIEFKYKANLGSASS..N..SLALSTYLNNIDTaRILTTYYLEIELLSN....TKIDNDILINVLNKSFGYIFSIrNLDNFSLSI.sNEYVPIKTFMITY.DKLHIIDKSAYVMTPKIN....................................GESVSFYVENgicnITIY..nFIYKNINCNINKNVIMSGE.G.ELII-IDNIK..HIFPFYFNLIKDNKI..SYTDRYKQIEFYNT--siinfksnmkihfrnknifkfe...........
Q9YW26_MSEPV/18-376                 .....thnp----VDNVHNEIELTYLFDNLLLLSNIA..sYT.ETKKKLQLEYIIKY...VDKSIKLRQRHEY-DYPNFEITNTYMIQKLTN-Q.WTIKKLINKIEe....nI.gN..EKFIIAHNTEEDNIKNNMiippKK.lIMSNVTIHILSSIYFIINgN.............VRVEFKLKGTLGAADN..N..KMMLQTYLNNVLTyKQFTSYYIEIEI--L....NKLSKDEFYRDITNAFRYIYSInNLNNFALST.kNISPSVKTFMLPF.DSLYLMDKSKYFLTSKIDgevvqftvkngicdivlynfifknkqtnipnhivmkGFGEYKKIDN...vKTIY..pFVFTEIYSTDSKQKYNTRY.E.MIKFYNDNIK..NKEFDITFKHKPIIP..IEKDIV----------neaiayyksl.......................
Q9EMR4_AMEPV/20-336                 .........NFDSNPNVNNEIEFTYINPDLRILSNIYt.dNN.ESKKKTYLEYVLKF...ANKKSKLRQKYKY-DYPTFEIANSYFLDKLTN-N.WERKTIISEDKi....nI.nK.nEYILLRHNTEYQ------....--..-DNDIELPLLNDILDKIN.VlfvsqlyiiindlIKVEFKIKSNIGPLSS..N..KLLLSTHFNDIETyRKNITYYLEIEVLSK....TKLDNNVLYDNLVKSFEYIYKSkNISNISLVT.iKNKPKIKTHMIQY.NKLNTIDKESYIMAIKIDgdvvefnvmngicniiiydmvyknfscnidkniqmiGMGEYIKVDN...vKKIY..pFYFSKLSYNNK--------.-.----------..---------------..----------------kiinni...........................
A0A3S7SVX5_9POXV/26-337             ........k-PKSLDDINHEVEIVFIQPPLITLNNVL...NI.SSKQESYILFSLTN...KEDRVKIRSYLPMSKVYGLDLKNIQLVDSIDNII.WEKKTLITEHI......V..D..KHCMVRYSTEEKHIFLDY....RK..YISAIRLELVNLIQLKIK.N.............ILIDFKIKYFLGSGAQ..A..KSSLLHVLNHPKS.KPNVSLEFEIISGND....YKIDKDIIFNEISTLFRNIFMG.NPKNIFMTP..EQKNPIKTRMIKK.QDITGLELDNLYITTKTD....................................GVGSLIKINK....NGIF...CYFSHLNYSIRYNLLKPID.K.QIVLYGEALK..HGKMWNIFLIKLIEP..ILDDRLKEKDFINDEL.................................
A0A0M3ZRQ5_9POXV/27-342             .......na--EIDDSKHHEIELILFKPPIITLTNLY...YI.ASSMESYIEFTMLP..iNKPNTKFRNRMSLSKIHGLDVKNNQLVENIDNII.WEQKTLIKKKD......I.aD.nSSCVIRYSIEEKTLFVDY....KK..YNSSIKLELVNLIRTRLR.N.............IVIDFKMKYFLGSGAQ..SasSSSLLCALNHPKN.KPSLILEFEIMI-QD....KTVTRNMLLDELCMVANALFLS.EPRHVRLCP..YLQPKLKTYLLKK.QELINIDTDNLYITGKTD....................................GIFSYVYIYH....RSIF...CYFNHLGYIKDYDISVDVE.E.PIYLYAEMRK..ENNIIYFTVIKVLLP..ELDDRLAELEFVNSNL.................................
Q6TVQ6_ORFSA/22-335                 ......rga---PEDEVHHEVELVLVDPPLSTLAATL...RL.ASETESFILFTVTA..lAKEEGKLRARVPMSRVVGLDVKNVQLVNAIDSIV.WERKALVEETA......L..Q..EGCLLRHSTERRHLFVDY....KK..YLSAIRVELVNRVRVRSK.E.............VVVDFKFKYFLGSGAQ..A..KSSLLHALNHPKV.RPSPTLEFEVVP-AG....EAVDEAAVLTELRAVAKALFMA.PTDAVFLLP..PAEMPVRTLMLQK.QEIPALDLDGLFAVSKTD....................................GVSASVRVDE....NGVF...CAFSHLAYTIRYPLAREVQ.G.RYRLWCEAVRpvGERVWSMFVLVVEEP..AGDDRVAAVAGAVEA-l................................
MCEL_VARV/27-338                    ......qgs---TAYEINNELELVFIKPPLITLTNVV...NI.STIQESFIRFTVTN...-KEGVKIRTKIPLSKVHGLDVKNVQLVDAIDNIV.WEKKSLVTENR......L..H..KECLLRLSTEERHIFLDY....KK..YGSSIRLELVNLIQAKTK.N.............FTIDFKLKYFLGSGAQ..S..KSSLLHAINHPKS.RPNTSLEIEFTPRDN....ETVPYDELIKELTTFSRHIFMA.SPENVILSP..PINAPIKTFMLPK.QDIVGMDLENLYAVTKTD....................................GIPITIRVTS....KGLY...CYFTHLGYIIRYPVKRIID.S.EVVVFGEAVK..-DKNWTVYLIKLIEPvnAISDRLEESKYVESKL.................................
#=GC SS_cons                        .......-----TTSSEEEEEEEEESS--SHHHHHHH...TT.-SEEEEEEEEEEE-...-SSSEEEEEEEEGGGS-SSS--HHHHHHT---SE.EEEEEEEEEEE......E..E..TTEEEEEEEEEEEE-TTS....GG..GGGG-EEEEEEEEEEE-S.S.............EEEEEEEEEEEEETT-..-..S-HHHHHHHSTTS.--EEEEEEEE--SSS....S---HHHHHHHHHHHHHHHHSS.-TTSEEE--..----SSEEEE--G.GGGSSS--TTEEEEE--S....................................SEEEEEEEET....TEEE...EEETTTTEEEEEEBSS--S.S.-EEEEEEEEE..-SSSEEEEEEEEES------SHHHHHHHHHHHT.................................
#=GC seq_cons                       ........t...ssp-lppEVELlaIpPPLITLoNlh...NI.uTtpESaIhFTlos...tccssKlRs+lPlS+lHGLDlKNsQLVDuIDNIl.WEKKoLlpEpc......l..c..cpCllRaSTEE+alFlDY....KK..YsSSI+LELVNLlps+lK.N.............lslDFKlKYFLGSGAQ..u..KSSLLHsLNHPKo.+PNsoLEhEIhs.ss....cplspcpLhpELssls+tlFMu.sP-NlhLsP...hpsPl+TaMLpK.Q-IsuL-L-sLYhsoKTD....................................Glsshl+lss....puIY...CYFoHLuYhIRYssp+pl-.s.plhLaGEAlK..tsp.WplalIKllpP..shsDRlcEhcaVpppL.................................
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