#=GF ID Reovirus_L2_4th
#=GF AC PF21062.1
#=GF DE Reovirus core-spike protein lambda-2 (L2), ferredoxin-like domain
#=GF AU Moxon SJ;0000-0003-4644-1816
#=GF AU Chuguransky S;0000-0002-0520-0736
#=GF SE Pfam-B_7350 (release 9.0)
#=GF GA 27.00 27.00;
#=GF TC 28.80 37.60;
#=GF NC 25.60 24.10;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 11531411
#=GF RT Mammalian reovirus L2 gene and lambda2 core spike protein
#=GF RT sequences and whole-genome comparisons of reoviruses type 1
#=GF RT Lang, type 2 Jones, and type 3 Dearing.
#=GF RA Breun LA, Broering TJ, McCutcheon AM, Harrison SJ, Luongo CL,
#=GF RA Nibert ML;
#=GF RL Virology 2001;287:333-348.
#=GF RN [2]
#=GF RM 10801118
#=GF RT Structure of the reovirus core at 3.6 A resolution.
#=GF RA Reinisch KM, Nibert ML, Harrison SC;
#=GF RL Nature. 2000;404:960-967.
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Reovirus core-spike protein VP1/lambda-2 (VP1/L2) forms a
#=GF CC pentamer that mediates enzymatic reactions in 5' capping of the
#=GF CC viral plus-strand transcripts [1]. It forms a hollow cylinder
#=GF CC with projecting turrets. Each VP1/L2 monomer consists of eight
#=GF CC domains with the most N-terminal domain at the base of the
#=GF CC turret and the most C-terminal domain at the top. This entry
#=GF CC represents the fourth domain, which adopts a ferredoxin-like
#=GF CC fold consisting of four beta-strands protected by alpha-helices
#=GF CC that probably functions as a structural support for the three
#=GF CC enzyme domains (two methyltransferase and GTase domains) [2].
#=GF SQ 12
#=GS LMBD2_REOVL/687-795 AC Q91RA6.1
#=GS LMBD2_REOVJ/686-794 AC Q91RA4.1
#=GS A0A1S6PCV8_9VIRU/691-800 AC A0A1S6PCV8.1
#=GS LMBD2_REOVD/687-795 AC P11079.2
#=GS A0A193BJ69_9VIRU/691-800 AC A0A193BJ69.1
#=GS E7DDK3_9VIRU/691-801 AC E7DDK3.1
#=GS A0A3G1DHK4_9VIRU/689-797 AC A0A3G1DHK4.1
#=GS W8P1A7_9VIRU/680-788 AC W8P1A7.1
#=GS VP1_AQRVG/692-801 AC B2BND9.1
#=GS A0A0B5CUT9_9VIRU/687-795 AC A0A0B5CUT9.1
#=GS A0A0B4ULB8_9REOV/691-800 AC A0A0B4ULB8.1
#=GS VP1_AQRVC/691-800 AC Q8JU62.1
LMBD2_REOVL/687-795 ..ISRQLPSFGYVDDGSSVTGIEMISLENPGFSN-MTQAARVGISGLCANVGNARKLISIHESHGARVLTITSRRSPASARRKARLRYLPLVDPRSLEVQARTILPSNPVLF........
LMBD2_REOVJ/686-794 ..ISRQLPSYGYVDDGSSVTGLEVISIENPGFST-MTQASRVAISALCANTGNSRKTISIYESHGARVLMLVSRRSPASAKRKARLRYLPLIDPRSLEVQSRTIMPSTPVLF........
A0A1S6PCV8_9VIRU/691-800 .v-MVHVPLLGESDDGQSSLGINACRQYSPDLPVAGVTTDLQSLAYQLATVVPSTSFLARQAFDGTTAVTFFGKRTFLSNRRMERLQDIPLPITTAIGHQSRFTGPPSYQLF........
LMBD2_REOVD/687-795 ..ISRQLPSFGYVDDGSSVTGIETISIENPGFSN-MTQAARIGISGLCANVGNARKSIAIYESHGARVLTITSRRSPASARRKSRLRYLPLIDPRSLEVQARTILPADPVLF........
A0A193BJ69_9VIRU/691-800 .l-MAHVPLLGDVDDGTTSLGFNACRLYGPDLPAVNVTPEVQTLAYQLATIVPSTSFIAREDYDGATAVTFYGKRTFLSRRRLDRLVSVPVPATNAINHQTRFTGSPTYQLF........
E7DDK3_9VIRU/691-801 .v-MQAIPTPNQSDSDTALIGMSTIQLFGTEAVVKTCNRGNRAITVLANRTGGTQLTFGIENFGGSSSLTLCGRRSLLSDRRLRRLKELPMTDLSSLSFQHRTAP-------fvtpsflf
A0A3G1DHK4_9VIRU/689-797 .a-LTDVPKRGVTDDGTNLSGILQINLLDTNFTG-DQSLNVMALAGLARRNDSAVITYATRNHFGSQMVTITGIRSKFGETRQERMMYTPVPILDAYQMQSRSIPYKTPVIF........
W8P1A7_9VIRU/680-788 ac--DRLPLRGITDRGDYDSGITQINIINPRLSVRWAD-DVAAISGLAMISDGHRAVMSRRKHHGAEMLTLTGVRSRYSLNRNRRMRVAPSPRLDAIVNQVRDIAYVDPQVF........
VP1_AQRVG/692-801 ..TMTHVPMLGQADDGTSALGMEAIRLFDPLFVEGNPNAATSALATLMANVVPSSIHMSRLPVNGPVSTTIFGKRTFLSTRRRDRLLEYPLPMVTAINHQRRFTAPPSFSIY........
A0A0B5CUT9_9VIRU/687-795 ..ISRQLPSFGYVDDGSSVTGIETISIENPGFSN-MTQAARIGISGLCANVGNARKSIAIYESHGARVLTITSRRSPASARRKSRLRYLPLIDPRSLEVQARTILPADPVLF........
A0A0B4ULB8_9REOV/691-800 .l-MAHVPLLGDVDTGATSLGFNACRLYSPDLPTVNITPEIQTLAYQLATIVPSTSFIAREDYDGATAVTFYGKRTFLSRNRLDRLVDVPVPATSAINHQTRFTGSPVYQLF........
VP1_AQRVC/691-800 ..AVTHIPFFGVPDDGTSDLGIDAVRLFDPMFSDAVANLPSNALASLVSRVVPSSIMFTRVPSNGPVSTTIYGKRTFLSNRRRARLRDVPMLITTTLVHQRRFTTPPTFTLF........
#=GC seq_cons ....pplPhhG.sDDGooshGlpsIplhsPshss.hssssh.ulusLsAslssupthhuhhp.cGupslTlhG+RohhSsRRpsRLp.lPlstssulphQsRhhssss..LF........
//
