GenomeNet

Database: Pfam
Entry: SAM_DrpA
LinkDB: SAM_DrpA
Original site: SAM_DrpA 
#=GF ID   SAM_DrpA
#=GF AC   PF18255.2
#=GF DE   DNA processing protein A sterile alpha motif domain
#=GF PI   DrpA_SAM;
#=GF AU   Smart A;0000-0002-6965-5633
#=GF SE   ECOD:EUF04873
#=GF GA   26.20 26.20;
#=GF TC   27.10 27.10;
#=GF NC   25.90 25.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   22904190
#=GF RT   Structure-function analysis of pneumococcal DprA protein reveals
#=GF RT   that dimerization is crucial for loading RecA recombinase onto
#=GF RT   DNA during transformation.
#=GF RA   Quevillon-Cheruel S, Campo N, Mirouze N, Mortier-Barriere I,
#=GF RA   Brooks MA, Boudes M, Durand D, Soulet AL, Lisboa J, Noirot P,
#=GF RA   Martin B, van Tilbeurgh H, Noirot-Gros MF, Claverys JP, Polard
#=GF RA   P;
#=GF RL   Proc Natl Acad Sci U S A. 2012;109:E2466-E2475.
#=GF DR   INTERPRO; IPR041104;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is the N-terminal domain found in DNA processing protein A
#=GF CC   (DprA) present in Streptococcus pneumoniae. DprA has recently
#=GF CC   been discovered to be a transformation-dedicated RecA loader.
#=GF CC   Transformation is believed to play a major role in genetic
#=GF CC   plasticity. This domain is known as the sterile alpha motif
#=GF CC   (SAM) domain. DprAs are able to form a type of dimer through
#=GF CC   SAM-SAM interactions, also known as N/N interactions [1].
#=GF SQ   50
#=GS A0A139NJU5_9STRE/1-62  AC A0A139NJU5.1
#=GS A0A0D6DXN4_9LACT/1-69  AC A0A0D6DXN4.1
#=GS A0A2X3VYZ8_9STRE/1-62  AC A0A2X3VYZ8.1
#=GS A0A0P6SP10_9STRE/1-62  AC A0A0P6SP10.1
#=GS A0A095ZCB4_9FIRM/3-64  AC A0A095ZCB4.1
#=GS A0A387BH02_9LACT/2-63  AC A0A387BH02.1
#=GS A0A172Q7E2_9STRE/1-62  AC A0A172Q7E2.1
#=GS A0A1G6CC08_9STRE/1-62  AC A0A1G6CC08.1
#=GS A0A2R5HKQ8_9LACT/2-63  AC A0A2R5HKQ8.1
#=GS A0A1Q8E9J9_9STRE/1-62  AC A0A1Q8E9J9.1
#=GS A0A1N1PPW9_9MYCO/5-66  AC A0A1N1PPW9.1
#=GS A0A139NRW2_9STRE/1-62  AC A0A139NRW2.1
#=GS A8AXH5_STRGC/1-62      AC A8AXH5.1
#=GS A0A3P1VFR9_9STRE/1-62  AC A0A3P1VFR9.1
#=GS A0A1E8GS26_9LACT/4-60  AC A0A1E8GS26.1
#=GS A0A139NMB2_9STRE/1-62  AC A0A139NMB2.1
#=GS F5X6H9_STRPX/1-62      AC F5X6H9.1
#=GS A0A2N8LCS8_9STRE/1-62  AC A0A2N8LCS8.1
#=GS A5M7M0_STREE/3-64      AC A5M7M0.1
#=GS F9VDX8_LACGL/2-63      AC F9VDX8.1
#=GS A0A224X0N9_9LACT/1-65  AC A0A224X0N9.1
#=GS A3CN35_STRSV/1-62      AC A3CN35.1
#=GS C0MFR6_STRS7/1-62      AC C0MFR6.1
#=GS F9HEL6_9STRE/1-62      AC F9HEL6.1
#=GS Q8DZU1_STRA5/1-63      AC Q8DZU1.1
#=GS B9DS67_STRU0/1-64      AC B9DS67.1
#=GS A0A1Q8RI11_9STRE/1-62  AC A0A1Q8RI11.1
#=GS DPRA_STRR6/3-64        AC Q8DPI7.2
#=GS A0A2A5RJC4_9LACT/2-63  AC A0A2A5RJC4.1
#=GS A0A0E4H474_9STRE/1-62  AC A0A0E4H474.1
#=GS A0A239SSK8_9STRE/1-62  AC A0A239SSK8.1
#=GS G5K366_9STRE/1-25      AC G5K366.1
#=GS T1ZFA2_STRIT/1-62      AC T1ZFA2.1
#=GS A0A139NKT1_9STRE/1-62  AC A0A139NKT1.1
#=GS Q8DUD4_STRMU/1-62      AC Q8DUD4.1
#=GS J0UZG3_STREE/1-49      AC J0UZG3.1
#=GS G5JMZ9_STRCG/1-62      AC G5JMZ9.1
#=GS A0A380KBA3_9STRE/1-62  AC A0A380KBA3.1
#=GS A0A2L0D4I4_9STRE/1-62  AC A0A2L0D4I4.1
#=GS G5JU84_9STRE/1-62      AC G5JU84.1
#=GS Q5M4N4_STRT2/1-62      AC Q5M4N4.1
#=GS V4SLH9_STRIN/1-62      AC V4SLH9.1
#=GS F9PVG6_9STRE/5-66      AC F9PVG6.1
#=GS A0A3L9DV38_9STRE/1-62  AC A0A3L9DV38.1
#=GS A4VV15_STRSY/30-91     AC A4VV15.1
#=GS A0A380KX97_9STRE/1-62  AC A0A380KX97.1
#=GS U5P323_9STRE/1-62      AC U5P323.1
#=GS Q99ZM5_STRP1/1-62      AC Q99ZM5.1
#=GS G5KFZ9_9STRE/1-62      AC G5KFZ9.1
#=GS T0URD5_9STRE/1-62      AC T0URD5.1
A0A139NJU5_9STRE/1-62             .MDNFDIYKLKKAGLSNKHILNILHHVKSTK.E.......K...LSLRNLAIISECRNPAIFIENYRQLDE---dvm.
A0A0D6DXN4_9LACT/1-69             .MTNFDLYRLKKAGMSNLVLNQFLDFISNVT.AddrqhpvL...LLLPKFIRQATMKHKGLFWERFKQLDIK--gk..
A0A2X3VYZ8_9STRE/1-62             .MNHFDIYKLKKAGLNNLNVINILNYQEKHQ.K.......S...LSLRDIAVVSDCKNPLQFIENYKNLDSKTL....
A0A0P6SP10_9STRE/1-62             .MNNFELYKLKRAGLTNLNILNIIDYQKSNQ.K.......S...LSLRDMAVVSGCRKPAQFIENYKQLNLKTL....
A0A095ZCB4_9FIRM/3-64             .IDNFEIYKLKQAGLSNQQVLKVLQYGEIYD.Q.......E...LSLETIAEASECRNPVVFMERYHKLT----fesm
A0A387BH02_9LACT/2-63             .ITNFDLFRWKNAGMTNLGVNKLLKFYRRYE.K.......K...ISLRQMGQVAQIKSIPNFIESYKNQNVKEL....
A0A172Q7E2_9STRE/1-62             .MNNFELFKLKQAGLSNLNVINILTYQKQKQ.K.......S...LSLRDMAVVSQCKDPLLFIEAYKNLNSKEL....
A0A1G6CC08_9STRE/1-62             .MNNFELFKLKKAGLSNLNILNILDYQKRVG.K.......S...LSLRDMAIVSKTKNPVLFMEAYKNLDIKEL....
A0A2R5HKQ8_9LACT/2-63             t-NNFDIFRWKMAGLSNRSVNRILDFLAESP.Q.......K...LPLRRLAEIGQPKSTVNFIEGYKSQDVKDL....
A0A1Q8E9J9_9STRE/1-62             .MNNFELFKLKKAGLTNLHIHKVLAHQERAG.K.......S...LSIKSIALVSTCPNPVLFIEQYKQLDIKA-c...
A0A1N1PPW9_9MYCO/5-66             .IDNFEIYKLKQAGLSNQQVLKVLQYGEIYD.Q.......E...LSLEKIAEASECRNPVVFMERYHKLT----fesm
A0A139NRW2_9STRE/1-62             .MNNFELYKLQRAGLQNHQILKVIHYAKMHK.K.......S...LSLRDVAVVSECRKPVLFMENYRSLDLLA-l...
A8AXH5_STRGC/1-62                 .MKNYDIYKMKHAGLTNGQVLNVLRYVENKE.K.......E...LSLRDIAVVSECRNPALFMERYKQIDDD--fl..
A0A3P1VFR9_9STRE/1-62             .MNNFEIFKLKKAGLTNLQVNKVLAYRKQTG.K.......S...LSLRNIAVASETSNPTFFMEQYKALDVKA-c...
A0A1E8GS26_9LACT/4-60             s-NGFDIYKLKRAGMTNLSILRVLENNENQ-.-.......-...-SLSQIAQLAGIKNQEIFIEKYKSLDIKN-....
A0A139NMB2_9STRE/1-62             .MNNFEIYKMKKAGLTNHQVLNVLRYAESRD.K.......E...LSLRDKAVVSECRNPALFMEKYKRLDLPA-l...
F5X6H9_STRPX/1-62                 .MNNFELFKLKKAGLTNLNILAILDYQEKQE.K.......S...LSLRNMAVVSKCKNPILFMEKYKALDIKEL....
A0A2N8LCS8_9STRE/1-62             .MNNFECYKLRKAGLKNHQVLNIIQYFKVNK.T.......S...MSLRNMAVASECTDPIKFMESYKQLNTKAL....
A5M7M0_STREE/3-64                 .ITNYEIYKLKKSGLTNQQILKVLEYGENVD.Q.......E...LLLGDIADISGCRNPAVFMERYFQIDDAHL....
F9VDX8_LACGL/2-63                 .IRNFEILRLKKAGMSNLGILKLIDYQERHE.A.......K...LTLRQLARIAEVKAVPNFIESYKSQDVKRL....
A0A224X0N9_9LACT/1-65             .MINFDIYRLKKAGMSNLMINQFLTLTRDSQ.E.......KnplVYLPAFVRQTRMKQPALFWEKFRSFDLKVL....
A3CN35_STRSV/1-62                 .MNNFEIYKMKKAGLTNHQVLNVLRYAESKD.G.......K...LSLRDKAVVSECRNPALFIEKYKRLDLPA-l...
C0MFR6_STRS7/1-62                 .MNNFELYKLKKAGLTNLNILNLIDYQQRNN.K.......S...LSLRDIAVVSCCKNPVLFIETYKQLNVALL....
F9HEL6_9STRE/1-62                 .MNNYEIYKMKQAGLTNAQVLNVLRYAETKD.K.......E...IPLRDIAVVSECRNPALFMERYNQIDDD--fl..
Q8DZU1_STRA5/1-63                 .MNHFELFKLKKAGLTNLNIHNIINYLKKNSlT.......S...LSVRNMAVVSKCKNPTFFIENYKQLDLKKL....
B9DS67_STRU0/1-64                 .MNNFDIFKLKCAGLKNHHILNIIAYMKHST.Qs.....lS...LSLRNMAVVSKCSDPITFIENYKALKSKEL....
A0A1Q8RI11_9STRE/1-62             .MDNFQLFKLKKAGLTNLNVLHILAYQKKKG.K.......S...LSLRDMAVVSKCRDPLIFIENYKNLNSKEL....
DPRA_STRR6/3-64                   .ITNYEIYKLKKSGLTNQQILKVLEYGENVD.Q.......E...LLLGDIADISGCRNPAVFMERYFQIDDAHL....
A0A2A5RJC4_9LACT/2-63             y-TNFDLFRLKDAGMTNLGLNKLLRFAETNP.V.......K...LSLRKMAQISGTKSIPDFIERYKSQDCKIL....
A0A0E4H474_9STRE/1-62             .MNNFEIFKLKKAGLSNLQVHKVLTYREKTG.K.......S...LSLRTVALVSETTKASLFMENYKALDIKT-c...
A0A239SSK8_9STRE/1-62             .MKAYDIFKWKQAGLTNLQINRILDYEQKAG.K.......K...LSDRDIVIVSEVKNPAVILEHYRNLDEA--qc..
G5K366_9STRE/1-25                 .------------------------------.-.......-...-----MAVASCCKDPIAFVEAYKQLDIKK-i...
T1ZFA2_STRIT/1-62                 .MNNFDIYKLKEAGLTNQQVINVLEYAEIHE.K.......D...LSAKGMAVVSECRNPALFIEKYLQLDDD--ll..
A0A139NKT1_9STRE/1-62             .MNTFELFKLKEAGLSNLNINHLLAYQEREK.R.......H...LSLRDMAVVSRVKNPSLFIQSYKQLDLAEL....
Q8DUD4_STRMU/1-62                 .MDNFQLFKLKKAGLTNLNILNIIDYEERTQ.K.......S...LSLRDMAVVSKNKKPLIFMEHYKNLDSKAL....
J0UZG3_STREE/1-49                 .-------------MTNQQILKVLEYGENVD.Q.......E...LLLGDIADISGCRNPAVFMERYFQIDDAHL....
G5JMZ9_STRCG/1-62                 .MNNFELFKLKKAGLTNLQILNILDYQKKVG.K.......S...LSLRDMAVVSQTSKAGHFMESYKHLDLKAL....
A0A380KBA3_9STRE/1-62             .MNNFELFKLKKAGLTNLNIINILDYQERVG.K.......S...LSLRDMAVVSKCKNPVAFIENYRALDSKTL....
A0A2L0D4I4_9STRE/1-62             .MNNFELYKLKKAGLSNQHILNILDYEAKYQ.K.......S...LSLRDRAVVSKCSNPVVFMEHYKNLDSKTL....
G5JU84_9STRE/1-62                 .MDNFQLFKLKKAGLTNLNILKIIEYQKTKK.K.......S...LSLRDMAVVSGCREPLLFMEQYKNLNSSV-l...
Q5M4N4_STRT2/1-62                 .MNNFELFKLKAAGLTNLNILNILDYQKNQD.K.......K...LSLRDMAVVSKSKNAVLFMEKYKNLDVKQL....
V4SLH9_STRIN/1-62                 .MNNFELYKLKKAGLKNHHILNIIHYSQQTK.K.......S...LSLRNMAVVSGTSKPCLFLENYKLLNIKEL....
F9PVG6_9STRE/5-66                 .IDNFEIYKLKQAGLSNQQVLKVLQYGEIYD.Q.......E...LSLETIAEASECRNPVVFMERYHKLT----fesm
A0A3L9DV38_9STRE/1-62             .MNNFDLYKLRKAGLTNLNILNILDYQKRVG.K.......S...LSLRDMAVVSQCKNPVLFIETFKNLNSKEL....
A4VV15_STRSY/30-91                .MNNFELFKWKKAGLTYLNVNKVLAYQEKHG.K.......K...LTLRNVAVVSECKNPVLFMENYKNLDTK--ac..
A0A380KX97_9STRE/1-62             .MENFEIYKLKKAGLSNQQVLNALEYEKRKG.K.......K...LSLRDIAVVSETVKPAIFMENYNQLDTDKL....
U5P323_9STRE/1-62                 .MNKYELYKLKVAGLSNLQVFSIVNYWEMNG.E.......W...PSLELMAKIAGCRNQTLFMERYIRIDDKVL....
Q99ZM5_STRP1/1-62                 .MNHFELYKLKKAGLTNKNILNILDYQKHQE.K.......S...LSLRDMAVVSGCKHPSHFIEAYKQLDIQNL....
G5KFZ9_9STRE/1-62                 .MNNFELYKLKKSGLANKAILNVLSYQEKNQ.K.......S...LSIRDIAVVSQTKDPVSFIENYKKIDSKEL....
T0URD5_9STRE/1-62                 .MNNFELFKLKQAGLTNLNILALLDYQSKQG.K.......S...LSLRDMAVASKCKNPILFMEKYKSLDSKSL....
#=GC seq_cons                     .MNNFElaKLK+AGLoNhplLplLcYtcppp.K.......p...LSLRchAVVScC+sPslFhEpYKpLD.KtL....
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