#=GF ID   SET1_RBD
#=GF AC   PF21569.1
#=GF DE   Histone-lysine N-methyltransferase, RNA-binding domain
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF AU   Lazaro Pinto Beatriz;0000-0001-6837-2941
#=GF SE   ECOD:EF20997
#=GF GA   27.00 27.00;
#=GF TC   27.20 27.30;
#=GF NC   26.70 26.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0221
#=GF RN   [1]
#=GF RM   31922488
#=GF RT   Structural basis for COMPASS recognition of an H2B-ubiquitinated
#=GF RT   nucleosome.
#=GF RA   Worden EJ, Zhang X, Wolberger C;
#=GF RL   Elife. 2020; [Epub ahead of print]
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain is found in Histone-lysine N-methyltransferase, H3
#=GF CC   lysine -4 specific from Saccharomyces cerevisiae (SET1) and
#=GF CC   similar proteins predominantly from yeast. SET1 is the
#=GF CC   methyltransferase subunit of the COMPASS (Set1C) complex that
#=GF CC   plays a role in telomere length maintenance and transcription
#=GF CC   elongation regulation [1]. This entry represents the RNA-binding
#=GF CC   domain (RBD), which shows an alpha-beta structure.
#=GF SQ   49
#=GS SET1_DEBHA/250-351        AC Q6BKL7.2
#=GS C5DCR8_LACTC/185-294      AC C5DCR8.1
#=GS A0A1S7HYF7_9SACH/194-301  AC A0A1S7HYF7.1
#=GS A0A1E4SZX2_9ASCO/235-337  AC A0A1E4SZX2.1
#=GS G3BF36_CANTC/221-318      AC G3BF36.1
#=GS J8LMY9_SACAR/257-366      AC J8LMY9.1
#=GS A0A1S7HLI5_9SACH/194-301  AC A0A1S7HLI5.1
#=GS A0A875RWD2_EENNA/234-335  AC A0A875RWD2.1
#=GS K0KFE8_WICCF/245-346      AC K0KFE8.1
#=GS A0A1G4IUF2_9SACH/193-302  AC A0A1G4IUF2.1
#=GS A0A8E2K046_9PEZI/177-287  AC A0A8E2K046.1
#=GS A0A7H9HQU7_9SACH/227-334  AC A0A7H9HQU7.1
#=GS J4U319_SACK1/253-362      AC J4U319.1
#=GS G3AEH0_SPAPN/232-332      AC G3AEH0.1
#=GS G8BXM6_TETPH/214-321      AC G8BXM6.1
#=GS A0A074YCD9_AURSE/97-184   AC A0A074YCD9.1
#=GS A0A2U9RA58_PICKU/265-367  AC A0A2U9RA58.1
#=GS A0A1G4MER2_LACFM/186-295  AC A0A1G4MER2.1
#=GS A0A376B1C8_9ASCO/256-369  AC A0A376B1C8.1
#=GS A7TGI1_VANPO/251-358      AC A7TGI1.1
#=GS SET1_YEAST/248-357        AC P38827.1
#=GS A0A1E5RPL7_9ASCO/280-396  AC A0A1E5RPL7.1
#=GS A0A1Q2YEC5_9ASCO/260-362  AC A0A1Q2YEC5.1
#=GS A0A4C2EDJ3_9SACH/206-313  AC A0A4C2EDJ3.1
#=GS A5DVI3_LODEL/265-370      AC A5DVI3.1
#=GS A0A7H9AVW3_ZYGMR/225-332  AC A0A7H9AVW3.1
#=GS A3LX95_PICST/211-311      AC A3LX95.2
#=GS SET1_KLULA/202-314        AC Q6CIT4.1
#=GS A0A074XF58_AURPU/171-257  AC A0A074XF58.1
#=GS SET1_CANGA/296-407        AC Q6FKB1.1
#=GS G8ZPU5_TORDC/210-317      AC G8ZPU5.1
#=GS W1QAA1_OGAPD/146-246      AC W1QAA1.1
#=GS A0A2P7Z6B5_9PEZI/221-310  AC A0A2P7Z6B5.1
#=GS G8YIW4_PICSO/234-336      AC G8YIW4.1
#=GS I2H1U6_TETBL/316-444      AC I2H1U6.1
#=GS A0A1E4SJ32_9ASCO/223-324  AC A0A1E4SJ32.1
#=GS A0A1G4J7K4_9SACH/193-302  AC A0A1G4J7K4.1
#=GS A0A1X7QZV7_9SACH/207-314  AC A0A1X7QZV7.1
#=GS J7S8V8_KAZNA/253-364      AC J7S8V8.1
#=GS C4R217_KOMPG/206-307      AC C4R217.1
#=GS A0A074W145_9PEZI/98-202   AC A0A074W145.1
#=GS H2AWB7_KAZAF/245-358      AC H2AWB7.1
#=GS A0A0C7N5C9_9SACH/196-305  AC A0A0C7N5C9.1
#=GS G8JXB0_ERECY/180-289      AC G8JXB0.1
#=GS A0A1E3NI34_9ASCO/258-360  AC A0A1E3NI34.1
#=GS A0A421JPD2_9ASCO/228-330  AC A0A421JPD2.1
#=GS SET1_ASHGO/170-279        AC Q75D88.2
#=GS G0VA57_NAUCC/256-368      AC G0VA57.1
#=GS G0W6Q9_NAUDC/265-377      AC G0W6Q9.1
SET1_DEBHA/250-351                   ............n-EIVVWDLPS--...-..-T.......TSEVYLSNFFKS..YGdS.IKDLKFINDPLNAVPLGIATCKFQ-...-..-GNPDK...S...........MRIAKKFIANVRI.NHT..KIDGA.ELKIALN.DN.D.N-.--------------kllddkikvaqdk.........
C5DCR8_LACTC/185-294                 .............NEIVVYPVFRDH...S..SA.......VQDIAIKNYFST..FG.E.ISHFQSFNDPISALPLYVYVVRYTG...P..PGNLDA...P...........FRAAYKAAKTFEN.SHY..FVSGF.KFAVSIN.RA.N.YS.QKIVDGFIQDNIKQ......................
A0A1S7HYF7_9SACH/194-301             ......nelilsl---------TSN...V..SS.......VQDVSIKNYFKK..YG.E.ISHFEAFNDPNSALPLHIYLIRYGS...L..SGKFDD...A...........AKAAYTAFKEYEE.KGC..SILGT.KFNCSLN.KS.N.ML.DRIISKTVAENLKK......................
A0A1E4SZX2_9ASCO/235-337             ............n-EIVIWNFPSTT...-..--.......-SLLIIRNNFTR..FG.K.ISEIHGTDDPDTAVPLGICKLSFDG...-..--DAEL...A...........HVAASNAAKKS-H.KQI..RINGA.VIQCGLN.TN.N.VL.YETVYK--------ktleikrme.............
G3BF36_CANTC/221-318                 ...........te--IVIWEL----...P..TT.......VSEIYMSNYFKT..YG.NaIKDLKFINDSVNGVPLGIATFEF--...-..QGKLEK...S...........ARLADKVIKDSKE.SGI..KMDGV.QVKVGLN.DH.D.--.--------------snflngkira............
J8LMY9_SACAR/257-366                 .............CEVVVYPAQSST...T..TN.......IQGISIKNYFKK..YG.E.ISHFEAFNDPNSALPLHVYLIKYTS...P..DGKIND...A...........AKSAFNAVRKHEA.SGC..FIMGF.SFDVILN.KY.S.IL.NNIISKFVEINVK-n.....................
A0A1S7HLI5_9SACH/194-301             .......nelvls------L--TSN...V..SS.......VQDVSIKNYFKK..YG.E.ISHFEAFNDPNSALPLHIYLIRYGS...L..SGKFDD...A...........AKAAYTAFKEYEE.KGC..SILGT.KFNCSLN.KS.N.ML.DRIITKTVAENLKK......................
A0A875RWD2_EENNA/234-335             elviwnfppttsi------------...-..--.......---MIIKNYFIP..FG.D.VREVHGVDDPRTAVPLGVCLLLFDG...-..--DPTI...A...........HEAASKAVSST-N.NIL..SVGGQ.AIKCGVN.IG.NkLY.HEIFDRVMEDKK--ek....................
K0KFE8_WICCF/245-346                 .....neivisgl------------...A..RA.......FNEIYLRNEVKK..HG.E.VLEFENVMDPTTGIPLGILRIRYGG...S..H---DR...A...........YRSVRKAVSDLNE.--T..TIEGR.KIQAGMN.REgK.LL.QSLKTKAIQER---elk...................
A0A1G4IUF2_9SACH/193-302             .............NEIVVYPVMCEP...T..AA.......LQDVIIKNYFTT..FG.E.ISHFESFNDPNSALPLYVYLIRFTG...P..HGNLDA...P...........SRSAYKAAKAHEE.RNY..FVAGF.KFAVALN.KG.D.CL.KQAKDRIIKKNAKQ......................
A0A8E2K046_9PEZI/177-287             .patqvvvtgfdp------------...-..-L.......IQESQIKALFGS..YG.E.IAELSNKTDPNTGSFLGVCLVKYRD...S.rPVRGGT...P...........IKAADAAKRAEKE.GNN..QRIGLrEVKVQLD.REgR.KC.KRFIAAVVERNRK-e.....................
A0A7H9HQU7_9SACH/227-334             ............i-EIIIYPAS--E...A..GI.......VNEVSVKNYFRK..FG.E.ISHFEAFSDPNNALPLHAYLVRYNH...P..EEKINE...A...........VQAAYKAVKEHET.KGC..VILGS.KFLVVLN.KG.S.IL.EKIISDLVNKNIQK......................
J4U319_SACK1/253-362                 .............CEIVVYPAQDST...T..TG.......IQDVSIKNYFKK..YG.E.ISHFEAFNDPNSALPLHVYLIKYTG...S..DGKIND...A...........AKSAFNAVRKHES.SGC..FIMGF.RFEVILN.KN.S.IL.SNIISKFVEMNAK-n.....................
G3AEH0_SPAPN/232-332                 ....qlvvwdlpa------------...-..-T.......TSEIYLSNYFRS..YG.DpIEDMKFINDPENAVPLGIATFKFQG...-..--NPEK...A...........TRLAQKLVQSIKS.EMP..KIDGV.LLKIGLN.DN.E.D-.--------------ellnkkielardk.........
G8BXM6_TETPH/214-321                 .............SEIVVYPK--GA...V..NS.......ISEASVKNYFKS..FG.G.ISNFESFNDPNSAISLNIYLIKFDS...P..NGKIQD...A...........IKSANNAVDKHTK.NDC..IIMGS.GFNVTLN.KN.D.FL.KTIISKTIAKNE--lk....................
A0A074YCD9_AURSE/97-184              .kqvvvygfdpit------------...-..--.......-PENQIKSYFAM..FG.D.IAEFRNQTDPDTGSLLGICLIKYKDskpP..KGPSVS...A...........ANAAKRAEKEGH-.---..-----.-------.--.-.--.--------------narigltqvrverd........
A0A2U9RA58_PICKU/265-367             ............n-EIVIWNLH---...-..ST.......TSSLVIKNNLSV..YG.S.ILELKMVDDPLTAVPLGMCTVSFD-...-..-GKVEQ...A...........HKIALKVIETCN-.KKL..LIQGR.YIRCGLN.VR.N.MLyNEIYEKSINA----rneh..................
A0A1G4MER2_LACFM/186-295             .............NEVVVYPLVRDQ...S..NS.......IQDSVIKGYFSG..FG.E.ISHFESFNDPNSALPLYVYLIRFTG...P..QGILDA...P...........YRSVYKAVKAHET.KSC..FISGF.KFAVVAN.KN.G.HV.NKIINKLVDENAKQ......................
A0A376B1C8_9ASCO/256-369             .............TEIVLHASNDTI...S..NNs.....lVQESTIKSYFKS.eFG.D.LSHFQSFIDPNSSLPLNIFLLKFAS...N.kTENVNI...P...........SKIAELAVRKYQN.KLY..SVNGV.KFKVSLN.KN.G.LC.AKLVEQLIAENLKQ......................
A7TGI1_VANPO/251-358                 .............TEIVIYPA--ST...I..NM.......ISELSVKNYFKE..FG.E.ISHFEVFNDPNSALSLNVYLVRYNS...P..DGKLKN...A...........IKAAKYAVQKHEE.KGC..SILGC.HFNVVLN.KD.N.VI.KSIISKFVQENLKK......................
SET1_YEAST/248-357                   .............CEIVVYPAQDST...T..TN.......IQDISIKNYFKK..YG.E.ISHFEAFNDPNSALPLHVYLIKYAS...S..DGKIND...A...........AKAAFSAVRKHES.SGC..FIMGF.KFEVILN.KH.S.IL.NNIISKFVEINVKK......................
A0A1E5RPL7_9ASCO/280-396             .............SEIVVHPIQTEL...S..KNmg...tiIPDSVIENHFKNefHL.P.ISQFQSFSDPNSLVPLNVFVLKFSS...P.kNEDLNL...P...........GKVAQKAVKKYEN.EPF..VTNGM.RFKVSLN.NN.A.LS.SKIVNEIVQHNLKE......................
A0A1Q2YEC5_9ASCO/260-362             ...neiliwnlhs------------...-..-T.......TTSLIIKNNFSQ..YG.P.ISEVKVIDDPSTAVPLGMCLLSFD-...-..-GKVEQ...A...........HTTALKTVE-LAN.KKL..VIQGR.YIRCGLNvKN.Q.LY.DEIYKKTMDVR---kek...................
A0A4C2EDJ3_9SACH/206-313             ............s-EIVLSLL--SN...V..VT.......VQDISIKNYFKR..YG.D.ISHFEAFSDPNSALPLHIYLIRYGS...Y..SGKLDD...A...........SKAAYMAFKDHEG.RGC..SILGT.KFNCSLN.KN.N.IL.EQTISRTVTENLN-r.....................
A5DVI3_LODEL/265-370                 .....viwdlpis------------...-..--.......VNMQYLKNYLGT..YG.L.IENIEIINDPNTAVPLGVATFRFKG...T..PEKSS-...-...........-DLATKFVERVKI.ELI..KINGI.ALKIGLN.DS.E.--.--------------dtllnqkvniargkiinqrlkr
A0A7H9AVW3_ZYGMR/225-332             .............NEVVIYFAS--D...V..NT.......IQDISVKNYFKK..YG.E.ISHFEPFYDPNNALPLHVYLIRYAS...S..HSGKSN...E...........FKAARLAVKEHEK.KGC..FILGV.KFNVILN.KD.D.SL.EKVISELVEKNIQK......................
A3LX95_PICST/211-311                 ...telvvwdlpa------------...-..-T.......TNEVYLTNYFKS..YG.DpIQDMKFVNDPINAVPLGIATFKFQG...P..PEK---...A...........MRLAKKLISIIRV.EGA..KVDGV.DLRIALN.DN.D.N-.--------------nllknkidlard..........
SET1_KLULA/202-314                   .............KEIIVYPSASNQqpiA..AA.......LSEAIIKNYFKS..FG.E.IAHFEQFMDPNSALPLYVYLIKFTG...P..VSQPDA...P...........YKAAYKASEKFKD.APY..TVSGI.KFNVILN.QN.T.VL.NSIKDKLIKQNAA-r.....................
A0A074XF58_AURPU/171-257             .kqivvhsfdpft------------...-..--.......-PESQLKSFFAS..FG.D.IAEFRNQTDPNTGSLLGICLIKYKD...S..KPVKGVsvsA...........ANAAKRAEKEAH-.---..-----.-------.--.-.--.--------------ngrigltqvkver.........
SET1_CANGA/296-407                   .............TEVVVFAENFSN...TqmAN.......IPDISIKNYFRK..FG.E.LAHFASYSDPKTALPLHLYLVKYTH...P..SGKIND...S...........AKAAYQAVKSCQE.QKC..CILGC.NFNVLLN.KN.N.EL.ENIMNKRITVLS--ke....................
G8ZPU5_TORDC/210-317                 ............i-EVVICPMS--D...V..GP.......VQDISIKNYFRK..YG.E.ISHFKAFNDPNNALPLHVYLVRYNS...S..ENKIND...A...........ANAAYRATKEHGE.RGC..IILGS.RFNVALN.KD.K.TL.DKVISELVEKNAEK......................
W1QAA1_OGAPD/146-246                 .lviwnfptttpl------------...-..--.......---VIIRNNFAQ..FG.K.ISDLKGIDDPLTAVPLGLCVLDYDG...D..---PDS...A...........HQAATKAVAAVH-.KKL..QIGGQ.YLRCGLN.NN.D.QLfNTIYNRILDTK---kqq...................
A0A2P7Z6B5_9PEZI/221-310             ..qivvtgfdpft------------...-..--.......-SEAQLKTFFSS..YG.E.VAEIQNQTDPNTASYLGICLIRYRD...SsrPSRGNA...T...........QAAATAAAKKAEK.E--..-----.-------.--.-.--.--------------atgeriglktikvecd......
G8YIW4_PICSO/234-336                 .telvvwdlpltt------------...-..--.......-SETYLINFFKS..FG.NsITDFKYINDPINAVPLGIATFKFSG...Y..PEK---...S...........MRIAKKFLNAVKA.ENI..KVDGV.ELKITFN.DR.D.--.SNILNSKIEE----anerl.................
I2H1U6_TETBL/316-444                 .............NEIIVYLSPDLT...S..NSisenfvsVQPLSIKNYFKT..FG.S.ISHFESLIDPNNALPLHLFLIRFDS..iS..DNAIDS...NnngqshnqmvgIRNAYKAYKAYQQ.SDC..YILGK.KFKVELN.EN.N.KL.LEMKQKIIEQNLR-s.....................
A0A1E4SJ32_9ASCO/223-324             ...telvvwdlpa------------...-..-T.......TSEVYLENYFRS..YG.DpIKDMKFINDPINAVPLGVGTFKFQG...N..P---EK...A...........QRLAKKLIQTLKA.ERA..KIDGV.EIRIGLN.DH.D.--.--------------gellqkridsanek........
A0A1G4J7K4_9SACH/193-302             .............SEIVVHAISRDP...K..NS.......VQDAIIKNYFST..FG.E.ISHFESFMDPNNALPLYVYVMRFTG...P..PGNLDA...P...........HRSAHKAFKTFEK.SCY..CVSGF.KFAVAIN.DN.N.QS.RKIIDAMIESNLKE......................
A0A1X7QZV7_9SACH/207-314             .............CEIIVYPV--SS...V..NS.......IQEILIKNHFRK..FG.E.ISHFESFNDPNNALPLHIYLIKYSS...P..EGKIND...A...........ARAAYMASKRYEN.ENC..SIIGS.NFKVVLN.KN.G.IL.ESTKIRFIAENKK-r.....................
J7S8V8_KAZNA/253-364                 .............CEIVVYPNGSATg.nV..IN.......VQDVMVKNYFKK..FG.E.ISHFESFSDPNNALPLHVFLIKYTS...P..NGKVND...A...........AKAAYMAMKRHEN.KTC..ILMGT.SFVVVLN.KD.D.RL.ASIKKQIMEEN---ppp...................
C4R217_KOMPG/206-307                 ...ieiiihglsp------------...-..-S.......TAQTVLKNNYKR..YG.P.IADCRAVVDPVTAVPLGLFVLSFS-...-..-GKIDE...A...........HTSCLKALNAA-K.DGV..RVNGG.VPRTTLF.SE.S.RL.NEIKHKIIKQNEN-k.....................
A0A074W145_9PEZI/98-202              .kqivvhsfdpft------------...-..--.......-PESQLKFFFAS..FG.D.IAEFRNQTDPNTGSFLGICLIRYKD...S..K-PIKG...V...........SVSATNAAKRAEK.EGHneRIGLT.KVKVELD.R-.-.--.--------------egrkcrkyveytlkka......
H2AWB7_KAZAF/245-358                 .............CEIVVYPAPNSV...N..LNi....mnLQDISIKNYFKK..YG.E.ISHFESFDDPNNALPLHLYLIKYTS...L..SSNINV...A...........SKSAYDAFKSHDNgKNC..FILGS.SFNISLN.KN.N.EV.EKIKQKIVDENLS-k.....................
A0A0C7N5C9_9SACH/196-305             .............NEIVVYPMGSDA...H..NS.......VADALIKSYFSS..FG.E.ISHFESFSDPSNALPLYVYVIRYTG...P..PGNFDA...P...........YKAAYKAAKNFEN.THY..FVSGL.KFAVALN.IN.H.KS.KNIVDAIIEENAKQ......................
G8JXB0_ERECY/180-289                 .............KEIIIFPVQKVN...A..AS.......IQDSIIKNFFGT..FG.E.IAHFESFNDPNSALPLNVYLIRYTD...L..EGNIDG...P...........YRHAYKAVKQFAK.QNY..LVSGI.RFAVKLN.KN.G.ML.KKTIDKFVNENVQ-r.....................
A0A1E3NI34_9ASCO/258-360             ...neiliwnlhs------------...-..-T.......TTSLIIKNNFSQ..YG.P.VSEVKVIDDPSTAVPLGMCLLSFD-...-..-GKVEQ...A...........HSTALKTVE-MAN.KRL..VIQGR.YIRCGLNvKN.Q.LY.DEIYNKTMDVR---kek...................
A0A421JPD2_9ASCO/228-330             ....qlvvwdlpa------------...-..-T.......TSEIYLSNYFRS..YG.DpIEDMKFINDPENAVPLGIATFKFQG...-..--NPEK...A...........TRLAQKLVQSIKS.EMP..KIDGV.PLKIALN.DN.E.N-.--------------ellnkktelardklk.......
SET1_ASHGO/170-279                   .............KEVVVFPKQREQ...A..LS.......VQDPIIKNFFGT..FG.E.VAHFESFNDPNNALPLNIYLVRYIN...V..EGNPDS...P...........YKAAYKAVKQFAK.QDY..LVSGA.RFAVRLN.MN.G.FL.QKTIDKFVTENLQ-r.....................
G0VA57_NAUCC/256-368                 .............CAIIVSPTSIIN...N..TM.......IQDISIKNYFKK..FG.V.ISHFESFNDPNSALPLHIYLIKYTA...P..NGKLSNldiP...........VKSAYQAVKEFKE.KGC..FIMGS.NFNVALN.KE.K.LL.EDIKTTLVEENIKK......................
G0W6Q9_NAUDC/265-377                 .............CELVIYPADDTN...I..TT.......IQDISIKNYFRK..FG.T.ISHFESFSDPNSALPLHIYLIKYTS...P..NDKLNNldlP...........GKSAYEAVKDFNK.KEC..LILGH.HFNVILN.KG.K.IL.QTIKDKTIDENLKK......................
#=GC seq_cons                        ...............lll..............s.......lp-l.IKNYF+p..aG.-.IucFcshsDPNoAlPLtlhLl+asu...s...uphss...u...........t+uAhcAl+phcp.cth..hI.Gh.phplsLN.cs.s.hh.pplhpchlppp...t.....................
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