#=GF ID SH3_4
#=GF AC PF06347.14
#=GF DE Bacterial SH3 domain
#=GF AU Moxon SJ;0000-0003-4644-1816
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Pfam-B_13248 (release 9.0)
#=GF GA 24.10 21.10;
#=GF TC 24.10 21.10;
#=GF NC 24.00 21.00;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 15335710
#=GF RT SH2 and SH3 domains.
#=GF RA Pawson T, Schlessingert J;
#=GF RL Curr Biol. 1993;3:434-442.
#=GF RN [2]
#=GF RM 11256992
#=GF RT SH3 domains: complexity in moderation.
#=GF RA Mayer BJ;
#=GF RL J Cell Sci. 2001;114:1253-1263.
#=GF RN [3]
#=GF RM 1639195
#=GF RT SH3--an abundant protein domain in search of a function.
#=GF RA Musacchio A, Gibson T, Lehto VP, Saraste M;
#=GF RL FEBS Lett. 1992;307:55-61.
#=GF RN [4]
#=GF RM 14731533
#=GF RT Signalling through SH2 and SH3 domains.
#=GF RA Mayer BJ, Baltimore D;
#=GF RL Trends Cell Biol. 1993;3:8-13.
#=GF RN [5]
#=GF RM 7531822
#=GF RT Protein modules and signalling networks.
#=GF RA Pawson T;
#=GF RL Nature. 1995;373:573-580.
#=GF RN [6]
#=GF RM 7953536
#=GF RT SH3 domains. Molecular 'Velcro'.
#=GF RA Morton CJ, Campbell ID;
#=GF RL Curr Biol. 1994;4:615-617.
#=GF RN [7]
#=GF RM 16597942
#=GF RT Discovery of natural atypical nonhemolytic Listeria seeligeri
#=GF RT isolates.
#=GF RA Volokhov D, George J, Anderson C, Duvall RE, Hitchins AD;
#=GF RL Appl Environ Microbiol. 2006;72:2439-2448.
#=GF DR INTERPRO; IPR010466;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC SH3 (src Homology-3) domains are small protein modules
#=GF CC containing approximately 50 amino acid residues [1, 2]. They are
#=GF CC found in a great variety of intracellular or membrane-associated
#=GF CC proteins [3, 4, 5] for example, in a variety of proteins with
#=GF CC enzymatic activity, in adaptor proteins, such as fodrin and
#=GF CC yeast actin binding protein ABP-1. The SH3 domain has a
#=GF CC characteristic fold which consists of five or six beta-strands
#=GF CC arranged as two tightly packed anti-parallel beta sheets. The
#=GF CC linker regions may contain short helices. The surface of the
#=GF CC SH3-domain bears a flat, hydrophobic ligand-binding pocket which
#=GF CC consists of three shallow grooves defined by conservative
#=GF CC aromatic residues in which the ligand adopts an extended
#=GF CC left-handed helical arrangement. The ligand binds with low
#=GF CC affinity but this may be enhanced by multiple interactions. The
#=GF CC region bound by the SH3 domain is in all cases proline-rich and
#=GF CC contains PXXP as a core-conserved binding motif. The function of
#=GF CC the SH3 domain is not well understood but they may mediate many
#=GF CC diverse processes such as increasing local concentration of
#=GF CC proteins, altering their subcellular location and mediating the
#=GF CC assembly of large multiprotein complexes [6]. This family
#=GF CC consists of several hypothetical bacterial proteins of unknown
#=GF CC function, but that contain an SH-3 region. Family members
#=GF CC include probable invasion-associated protein p60 that are
#=GF CC conceptually translated from iap genes. The iap gene, which is
#=GF CC regarded as a virulence-associated gene in L. monocytogenes,
#=GF CC codes for a gene product that has murein-lytic activity and is
#=GF CC involved in cell division [7].
#=GF SQ 2807
#=GS B0T7B5_CAUSK/119-173 AC B0T7B5.1
#=GS A0A165NRP4_9SPHN/33-89 AC A0A165NRP4.1
#=GS A0A285S0X7_9RHOB/80-136 AC A0A285S0X7.1
#=GS F6EV91_SPHCR/34-90 AC F6EV91.1
#=GS A0A3S8UBU1_9RHOB/153-206 AC A0A3S8UBU1.1
#=GS A0A1H3M1M9_9RHOB/40-96 AC A0A1H3M1M9.1
#=GS A0A239PP83_9RHOB/138-192 AC A0A239PP83.1
#=GS A0A1I7EE52_9RHIZ/322-373 AC A0A1I7EE52.1
#=GS G0AE33_COLFT/96-151 AC G0AE33.1
#=GS A0A3D9FDA7_9SPHN/84-138 AC A0A3D9FDA7.1
#=GS T0HIP9_9SPHN/88-142 AC T0HIP9.1
#=GS A0A3N5CP79_9SPHN/34-90 AC A0A3N5CP79.1
#=GS J3HTP1_9RHIZ/53-109 AC J3HTP1.1
#=GS Q11BB6_CHESB/52-108 AC Q11BB6.1
#=GS A0A196QPE0_9RHOB/44-100 AC A0A196QPE0.1
#=GS A0A370G9A2_GLULI/305-360 AC A0A370G9A2.1
#=GS A0A2A8CXI8_9BACT/201-270 AC A0A2A8CXI8.1
#=GS A0A432C7G9_9FLAO/191-245 AC A0A432C7G9.1
#=GS A0A085U193_9RHOB/147-201 AC A0A085U193.1
#=GS A0A431TCJ4_9BURK/28-82 AC A0A431TCJ4.1
#=GS A0A2Z4UNP6_9RHIZ/124-178 AC A0A2Z4UNP6.1
#=GS A0A1I3AH07_9PROT/219-273 AC A0A1I3AH07.1
#=GS A0A1G7U250_9PROT/40-96 AC A0A1G7U250.1
#=GS B1ZJ96_METPB/129-189 AC B1ZJ96.1
#=GS A0A218KNA4_9RICK/27-83 AC A0A218KNA4.1
#=GS A0A437MHN9_9PROT/75-131 AC A0A437MHN9.1
#=GS A0A2T6ASM6_9RHOB/143-197 AC A0A2T6ASM6.1
#=GS E8TLT4_MESCW/123-177 AC E8TLT4.1
#=GS Q1GJF4_RUEST/75-131 AC Q1GJF4.1
#=GS A0A178MV06_9PROT/39-95 AC A0A178MV06.1
#=GS K2GNF4_9RHOB/107-161 AC K2GNF4.1
#=GS A0A0S9CJZ5_9SPHN/40-96 AC A0A0S9CJZ5.1
#=GS A0A0N9UWL7_SPHMC/34-90 AC A0A0N9UWL7.1
#=GS A0A147ECR8_9SPHN/100-154 AC A0A147ECR8.1
#=GS A0A1C6LLH1_9NEIS/90-146 AC A0A1C6LLH1.1
#=GS B8EM25_METSB/48-104 AC B8EM25.1
#=GS Q2KDX5_RHIEC/46-102 AC Q2KDX5.1
#=GS A0A243WH08_9BACT/331-384 AC A0A243WH08.1
#=GS A0A4U6BXU8_9RHIZ/231-283 AC A0A4U6BXU8.1
#=GS A0A074JP28_9RHOB/175-229 AC A0A074JP28.1
#=GS A0A2P2EB42_9PROT/117-171 AC A0A2P2EB42.1
#=GS A0A1M6R8E7_9RHOB/45-101 AC A0A1M6R8E7.1
#=GS A0A0Q5CKH4_9BURK/28-83 AC A0A0Q5CKH4.1
#=GS A0A126ZH09_9BURK/33-86 AC A0A126ZH09.1
#=GS A0A419A040_9RHOB/63-119 AC A0A419A040.1
#=GS U5QFD2_9CYAN/233-283 AC U5QFD2.1
#=GS A0A1G7DJM1_9RHOB/138-194 AC A0A1G7DJM1.1
#=GS A0A0Q7D9A0_9CAUL/54-110 AC A0A0Q7D9A0.1
#=GS A0A095D3K5_9SPHN/36-92 AC A0A095D3K5.1
#=GS A9CWN8_HOEPD/54-110 AC A9CWN8.1
#=GS K2JUW7_9PROT/28-84 AC K2JUW7.1
#=GS A0A1B2AF27_9SPHN/72-126 AC A0A1B2AF27.1
#=GS E1QM68_DESB2/29-84 AC E1QM68.1
#=GS A0A444IX76_9DELT/125-179 AC A0A444IX76.1
#=GS A0A1N6F0S1_9SPHN/97-150 AC A0A1N6F0S1.1
#=GS A0A1K1MPW0_9PROT/24-79 AC A0A1K1MPW0.1
#=GS A0A086MGS9_9RHIZ/111-169 AC A0A086MGS9.1
#=GS A0A0C3NMD3_9PORP/195-250 AC A0A0C3NMD3.1
#=GS A0A031K8D4_9SPHN/100-154 AC A0A031K8D4.1
#=GS A0A3P3D769_9RHOB/78-134 AC A0A3P3D769.1
#=GS Q2S554_SALRD/102-146 AC Q2S554.1
#=GS A0A166TML6_9RHOB/43-99 AC A0A166TML6.1
#=GS A0A2K9EJG5_9RHOB/111-165 AC A0A2K9EJG5.1
#=GS A0A2H6BI88_9RHIZ/59-115 AC A0A2H6BI88.1
#=GS A0A075JSF5_9BACI/110-164 AC A0A075JSF5.1
#=GS A0A1X7A7E8_9RHOB/86-142 AC A0A1X7A7E8.1
#=GS A0A2Z3IDH5_9RHIZ/113-172 AC A0A2Z3IDH5.1
#=GS Q89WC4_BRADU/114-168 AC Q89WC4.1
#=GS A0A1H0H852_9BRAD/46-102 AC A0A1H0H852.1
#=GS N9WCZ6_9SPHN/97-151 AC N9WCZ6.1
#=GS A0A099F484_9RHOB/153-207 AC A0A099F484.1
#=GS A0A0P1GF82_9RHOB/30-86 AC A0A0P1GF82.1
#=GS A0A429VCN5_9SPHN/34-90 AC A0A429VCN5.1
#=GS S7TVQ0_DESML/29-84 AC S7TVQ0.1
#=GS A0A239DYX0_9SPHN/47-103 AC A0A239DYX0.1
#=GS A0A1I4F5F8_9PROT/230-279 AC A0A1I4F5F8.1
#=GS A0A0K6IVY8_9PROT/51-96 AC A0A0K6IVY8.1
#=GS B8FEY0_DESAL/89-143 AC B8FEY0.1
#=GS F6IQ19_9SPHN/35-91 AC F6IQ19.1
#=GS A0A2T6F5Q2_9BURK/87-143 AC A0A2T6F5Q2.1
#=GS A0A0Q6A392_9RHIZ/118-178 AC A0A0Q6A392.1
#=GS H0I3L9_9RHIZ/211-264 AC H0I3L9.1
#=GS A0A1G7E8I0_9PROT/111-163 AC A0A1G7E8I0.1
#=GS A0A0D0PH51_9RHOB/102-158 AC A0A0D0PH51.1
#=GS A0A1L9BUD3_9RHOB/88-142 AC A0A1L9BUD3.1
#=GS A0A1L3JB73_9SPHN/109-162 AC A0A1L3JB73.1
#=GS A0A1Z1FEM5_9SPHN/79-138 AC A0A1Z1FEM5.1
#=GS A0A1H3LQX2_9RHOB/104-157 AC A0A1H3LQX2.1
#=GS A0A1Y3G586_9PROT/150-206 AC A0A1Y3G586.1
#=GS A0A2V3U775_9RHIZ/85-141 AC A0A2V3U775.1
#=GS Q0FMQ4_PELBH/104-158 AC Q0FMQ4.1
#=GS A0A418XQH3_9BURK/28-83 AC A0A418XQH3.1
#=GS A0A0B5DYL2_9RHOB/66-122 AC A0A0B5DYL2.1
#=GS A0A127AYB1_9BACT/334-388 AC A0A127AYB1.1
#=GS A0A369Q5Q3_9SPHN/26-82 AC A0A369Q5Q3.1
#=GS A0A0C5KUT2_9SPHN/96-150 AC A0A0C5KUT2.1
#=GS A0A222DZW1_9RHOB/31-82 AC A0A222DZW1.1
#=GS A0A327JMC3_9RHIZ/90-144 AC A0A327JMC3.1
#=GS A0A495SIA7_9FLAO/191-245 AC A0A495SIA7.1
#=GS A0A2S6BKY5_9RHIZ/34-89 AC A0A2S6BKY5.1
#=GS H3SGF4_9BACL/196-250 AC H3SGF4.1
#=GS K9H489_9PROT/123-178 AC K9H489.1
#=GS A0A1G5I3Y6_9DELT/93-147 AC A0A1G5I3Y6.1
#=GS A0A2C9DAU9_9RHIZ/55-111 AC A0A2C9DAU9.1
#=GS A0A0Q5VGB0_9CAUL/84-138 AC A0A0Q5VGB0.1
#=GS A0A2T4JCX3_RHOBL/119-173 AC A0A2T4JCX3.1
#=GS A0A0P0IIH4_BLAVI/118-172 AC A0A0P0IIH4.1
#=GS A0A1I7N5M6_9RHIZ/32-85 AC A0A1I7N5M6.1
#=GS I3TRK0_TISMK/74-130 AC I3TRK0.1
#=GS A0A1H3FZ49_9PROT/109-164 AC A0A1H3FZ49.1
#=GS A0A0Q8QQL3_9BURK/91-147 AC A0A0Q8QQL3.1
#=GS A0A423PQU8_9GAMM/292-346 AC A0A423PQU8.1
#=GS A0A285PE32_9RHIZ/59-115 AC A0A285PE32.1
#=GS A0A074TEH2_9RHOB/172-226 AC A0A074TEH2.1
#=GS A0A1I1ZYQ9_9PROT/104-160 AC A0A1I1ZYQ9.1
#=GS A0A2Z6I547_9RHIZ/47-103 AC A0A2Z6I547.1
#=GS D7DN19_METV0/97-154 AC D7DN19.1
#=GS A0A0Q4BUG3_9SPHN/34-89 AC A0A0Q4BUG3.1
#=GS A8ZSZ2_DESOH/33-88 AC A8ZSZ2.1
#=GS J6UB33_9RHOB/129-183 AC J6UB33.1
#=GS A0A1D8UWP7_9PROT/248-303 AC A0A1D8UWP7.1
#=GS A0A316GG18_9RHOB/8-64 AC A0A316GG18.1
#=GS A0A370G572_9COXI/22-79 AC A0A370G572.1
#=GS A0A1Y5RWM4_9RHOB/111-165 AC A0A1Y5RWM4.1
#=GS A9B673_HERA2/113-167 AC A9B673.1
#=GS A0A269VXX2_9BACL/177-231 AC A0A269VXX2.1
#=GS C6XFT4_LIBAP/133-186 AC C6XFT4.1
#=GS A0A175RSW6_9RHIZ/150-204 AC A0A175RSW6.1
#=GS A0A345QD65_9RHOB/35-91 AC A0A345QD65.1
#=GS F4QLG8_9CAUL/63-119 AC F4QLG8.1
#=GS K2LNW5_9RHIZ/125-179 AC K2LNW5.1
#=GS A0A366JW13_9RHOB/56-112 AC A0A366JW13.1
#=GS E2CLX3_9RHOB/297-349 AC E2CLX3.1
#=GS A0A2Z5YXZ6_9SPHN/96-150 AC A0A2Z5YXZ6.1
#=GS A0A0D6MSN5_ACEAC/311-366 AC A0A0D6MSN5.1
#=GS A0A0B2BYX4_9SPHN/26-82 AC A0A0B2BYX4.1
#=GS A0A1A9NIF5_9PROT/94-150 AC A0A1A9NIF5.1
#=GS A9CWN8_HOEPD/125-179 AC A9CWN8.1
#=GS A0A1G7SQL3_9RHIZ/53-109 AC A0A1G7SQL3.1
#=GS A0A2W7N7R4_9RHOB/112-166 AC A0A2W7N7R4.1
#=GS A0A1X7NDV1_9RHIZ/123-177 AC A0A1X7NDV1.1
#=GS A0A1X7I9V8_9BURK/30-86 AC A0A1X7I9V8.1
#=GS A0A1I1L714_9RHOB/27-82 AC A0A1I1L714.1
#=GS A0A1Y5T825_9RHOB/41-97 AC A0A1Y5T825.1
#=GS A0A1A9G4Z7_9RHIZ/117-171 AC A0A1A9G4Z7.1
#=GS K2GNF4_9RHOB/44-100 AC K2GNF4.1
#=GS A0A398BAU7_9BACI/97-153 AC A0A398BAU7.1
#=GS A0A1B6YSB6_9RHOB/55-111 AC A0A1B6YSB6.1
#=GS A0A0Q6BQ88_9RHIZ/128-182 AC A0A0Q6BQ88.1
#=GS A0A0K1K718_9BURK/30-85 AC A0A0K1K718.1
#=GS A0A2A7UUW6_COMTR/149-204 AC A0A2A7UUW6.1
#=GS A0A2R8B309_9RHOB/113-167 AC A0A2R8B309.1
#=GS A0A098UD11_9BURK/94-150 AC A0A098UD11.1
#=GS A0A418WEW1_9PROT/56-112 AC A0A418WEW1.1
#=GS Q9ZCE7_RICPR/105-159 AC Q9ZCE7.1
#=GS A0A085EQ66_9RHIZ/137-198 AC A0A085EQ66.1
#=GS A0A0L6CQB0_9RHOB/41-97 AC A0A0L6CQB0.1
#=GS R5K546_9CLOT/74-127 AC R5K546.1
#=GS A0A1V4CI67_9BURK/36-90 AC A0A1V4CI67.1
#=GS A0A0D6JFQ4_9RHIZ/63-119 AC A0A0D6JFQ4.1
#=GS X4ZHM3_9BACL/176-231 AC X4ZHM3.1
#=GS A0A1Y3VG93_9BACT/230-279 AC A0A1Y3VG93.1
#=GS A0A370L8J5_9BRAD/111-165 AC A0A370L8J5.1
#=GS A0A370QJY0_9FLAO/196-247 AC A0A370QJY0.1
#=GS A0A1G9I8N8_9RHOB/101-157 AC A0A1G9I8N8.1
#=GS A0A1W6NWV0_9RHOB/86-142 AC A0A1W6NWV0.1
#=GS C7JDX1_ACEP3/165-221 AC C7JDX1.1
#=GS J4VTD6_9PORP/193-249 AC J4VTD6.1
#=GS A0A0Q6SBA9_9RHIZ/29-84 AC A0A0Q6SBA9.1
#=GS A0A1W6MW24_9RHIZ/54-110 AC A0A1W6MW24.1
#=GS A0A0Q6EPB9_9RHIZ/88-141 AC A0A0Q6EPB9.1
#=GS A0A1B3NM08_9BRAD/115-169 AC A0A1B3NM08.1
#=GS A0A3M9MXR5_9BACT/336-390 AC A0A3M9MXR5.1
#=GS A0A061QGY6_9PROT/101-157 AC A0A061QGY6.1
#=GS A0A0D8CJ13_9PROT/43-99 AC A0A0D8CJ13.1
#=GS V7EPL9_9RHOB/90-146 AC V7EPL9.1
#=GS A0A1B6ZE07_9SPHN/33-89 AC A0A1B6ZE07.1
#=GS W4HM38_9RHOB/44-100 AC W4HM38.1
#=GS A0A1G4U3C1_9SPHN/35-91 AC A0A1G4U3C1.1
#=GS A0A090DES7_9RHIZ/248-298 AC A0A090DES7.1
#=GS A0A420ERG5_9SPHN/101-155 AC A0A420ERG5.1
#=GS A0A1H0J409_9RHIZ/53-109 AC A0A1H0J409.1
#=GS A0A2M8ZTJ5_9BRAD/55-107 AC A0A2M8ZTJ5.1
#=GS A0A1Y5T825_9RHOB/104-158 AC A0A1Y5T825.1
#=GS A0A0T2YGN2_9BURK/35-89 AC A0A0T2YGN2.1
#=GS A0A1E2RW41_9RHIZ/119-173 AC A0A1E2RW41.1
#=GS A0A1P8USZ1_9RHOB/104-158 AC A0A1P8USZ1.1
#=GS A0A0N1LEH4_9SPHN/91-145 AC A0A0N1LEH4.1
#=GS A0A3B0M5U4_9RHOB/98-152 AC A0A3B0M5U4.1
#=GS A0A2T5BEG2_MYCDI/115-169 AC A0A2T5BEG2.1
#=GS A0A212PYQ4_9PROT/129-182 AC A0A212PYQ4.1
#=GS D8EYW0_9DELT/201-254 AC D8EYW0.1
#=GS A0A2L0EXE0_SORCE/28-82 AC A0A2L0EXE0.1
#=GS A0A3P3WAX9_9FLAO/191-245 AC A0A3P3WAX9.1
#=GS A0A1L9P107_9RHOB/103-157 AC A0A1L9P107.1
#=GS A0A3D9BSH9_9RHOB/43-99 AC A0A3D9BSH9.1
#=GS A0A257ERQ8_9PROT/110-163 AC A0A257ERQ8.1
#=GS A0A0T1WR34_9RHIZ/117-171 AC A0A0T1WR34.1
#=GS Q1YFI3_AURMS/50-106 AC Q1YFI3.1
#=GS J3HTP1_9RHIZ/123-177 AC J3HTP1.1
#=GS A0A1Q9AUD6_9RHIZ/101-155 AC A0A1Q9AUD6.1
#=GS A0A164B934_9MICO/549-603 AC A0A164B934.1
#=GS A0A097EKG5_9SPHN/100-154 AC A0A097EKG5.1
#=GS Q1QS52_NITHX/56-112 AC Q1QS52.1
#=GS A0A2T7FYB5_9RHOB/117-171 AC A0A2T7FYB5.1
#=GS A0A2H5F3K0_9RHOB/67-123 AC A0A2H5F3K0.1
#=GS A0A0M2R630_9PROT/131-183 AC A0A0M2R630.1
#=GS E3EY61_KETVY/109-165 AC E3EY61.1
#=GS A0A2S5JES9_9RHOB/64-120 AC A0A2S5JES9.1
#=GS A0A1S8D5S6_9PROT/219-275 AC A0A1S8D5S6.1
#=GS A0A1W2AFH6_9RHIZ/132-186 AC A0A1W2AFH6.1
#=GS A0A3T0N958_9RHOB/114-168 AC A0A3T0N958.1
#=GS A0A2L0WDJ9_9RHIZ/54-110 AC A0A2L0WDJ9.1
#=GS A0A1H9GFP1_9RHOB/39-95 AC A0A1H9GFP1.1
#=GS A0A0X8GQA6_9BURK/30-85 AC A0A0X8GQA6.1
#=GS A0A2T6BE61_9RHOB/39-95 AC A0A2T6BE61.1
#=GS A0A1G5G5V9_9RHIZ/112-170 AC A0A1G5G5V9.1
#=GS V7FKV3_9RHIZ/53-109 AC V7FKV3.1
#=GS Q0BQ90_GRABC/216-272 AC Q0BQ90.1
#=GS A0A0D6AZR2_RHOSU/101-155 AC A0A0D6AZR2.1
#=GS A0A2A8HWN8_9SPHN/33-89 AC A0A2A8HWN8.1
#=GS A0A0P6VX19_9RHIZ/39-95 AC A0A0P6VX19.1
#=GS A0A2R7LBC7_9CAUL/52-108 AC A0A2R7LBC7.1
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