#=GF ID SH3_4
#=GF AC PF06347.19
#=GF DE Bacterial SH3 domain
#=GF AU Moxon SJ;0000-0003-4644-1816
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Pfam-B_13248 (release 9.0)
#=GF GA 24.10 21.10;
#=GF TC 24.10 21.10;
#=GF NC 24.00 21.00;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 81514348 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF CL CL0010
#=GF RN [1]
#=GF RM 15335710
#=GF RT SH2 and SH3 domains.
#=GF RA Pawson T, Schlessingert J;
#=GF RL Curr Biol. 1993;3:434-442.
#=GF RN [2]
#=GF RM 11256992
#=GF RT SH3 domains: complexity in moderation.
#=GF RA Mayer BJ;
#=GF RL J Cell Sci. 2001;114:1253-1263.
#=GF RN [3]
#=GF RM 1639195
#=GF RT SH3--an abundant protein domain in search of a function.
#=GF RA Musacchio A, Gibson T, Lehto VP, Saraste M;
#=GF RL FEBS Lett. 1992;307:55-61.
#=GF RN [4]
#=GF RM 14731533
#=GF RT Signalling through SH2 and SH3 domains.
#=GF RA Mayer BJ, Baltimore D;
#=GF RL Trends Cell Biol. 1993;3:8-13.
#=GF RN [5]
#=GF RM 7531822
#=GF RT Protein modules and signalling networks.
#=GF RA Pawson T;
#=GF RL Nature. 1995;373:573-580.
#=GF RN [6]
#=GF RM 7953536
#=GF RT SH3 domains. Molecular 'Velcro'.
#=GF RA Morton CJ, Campbell ID;
#=GF RL Curr Biol. 1994;4:615-617.
#=GF RN [7]
#=GF RM 16597942
#=GF RT Discovery of natural atypical nonhemolytic Listeria seeligeri
#=GF RT isolates.
#=GF RA Volokhov D, George J, Anderson C, Duvall RE, Hitchins AD;
#=GF RL Appl Environ Microbiol. 2006;72:2439-2448.
#=GF DR INTERPRO; IPR010466;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC SH3 (src Homology-3) domains are small protein modules
#=GF CC containing approximately 50 amino acid residues [1, 2]. They are
#=GF CC found in a great variety of intracellular or membrane-associated
#=GF CC proteins [3, 4, 5] for example, in a variety of proteins with
#=GF CC enzymatic activity, in adaptor proteins, such as fodrin and
#=GF CC yeast actin binding protein ABP-1. The SH3 domain has a
#=GF CC characteristic fold which consists of five or six beta-strands
#=GF CC arranged as two tightly packed anti-parallel beta sheets. The
#=GF CC linker regions may contain short helices. The surface of the
#=GF CC SH3-domain bears a flat, hydrophobic ligand-binding pocket which
#=GF CC consists of three shallow grooves defined by conservative
#=GF CC aromatic residues in which the ligand adopts an extended
#=GF CC left-handed helical arrangement. The ligand binds with low
#=GF CC affinity but this may be enhanced by multiple interactions. The
#=GF CC region bound by the SH3 domain is in all cases proline-rich and
#=GF CC contains PXXP as a core-conserved binding motif. The function of
#=GF CC the SH3 domain is not well understood but they may mediate many
#=GF CC diverse processes such as increasing local concentration of
#=GF CC proteins, altering their subcellular location and mediating the
#=GF CC assembly of large multiprotein complexes [6]. This family
#=GF CC consists of several hypothetical bacterial proteins of unknown
#=GF CC function, but that contain an SH-3 region. Family members
#=GF CC include probable invasion-associated protein p60 that are
#=GF CC conceptually translated from iap genes. The iap gene, which is
#=GF CC regarded as a virulence-associated gene in L. monocytogenes,
#=GF CC codes for a gene product that has murein-lytic activity and is
#=GF CC involved in cell division [7].
#=GF SQ 3837
#=GS A0A418XQH3_9BURK/90-146 AC A0A418XQH3.1
#=GS A0A0S2EIG0_9HYPH/132-186 AC A0A0S2EIG0.1
#=GS A0A8J2XV13_9BURK/102-158 AC A0A8J2XV13.1
#=GS A0A0Q4KX78_9SPHN/100-154 AC A0A0Q4KX78.1
#=GS Q3SG94_THIDA/36-91 AC Q3SG94.1
#=GS A0A512HA63_9PROT/53-109 AC A0A512HA63.1
#=GS A0A839Z253_9SPHN/33-89 AC A0A839Z253.1
#=GS A0A0M2R630_9PROT/65-121 AC A0A0M2R630.1
#=GS A0A4R6R8V3_9HYPH/47-103 AC A0A4R6R8V3.1
#=GS A0A0Q9HTQ3_9HYPH/121-175 AC A0A0Q9HTQ3.1
#=GS D3NR23_AZOS1/101-155 AC D3NR23.1
#=GS A0A0V7YYB8_9HYPH/32-82 AC A0A0V7YYB8.1
#=GS A0A1B1AIJ0_9PROT/44-98 AC A0A1B1AIJ0.1
#=GS A0A1E5Q3T5_9PROT/56-112 AC A0A1E5Q3T5.1
#=GS A0A178MW27_9PROT/31-87 AC A0A178MW27.1
#=GS N6YG11_THAL4/97-153 AC N6YG11.1
#=GS A0A2N4YDN3_9RHOB/76-132 AC A0A2N4YDN3.1
#=GS A0A0D6TEK2_9RHOB/31-87 AC A0A0D6TEK2.1
#=GS A0A0G3BPB1_9BURK/29-82 AC A0A0G3BPB1.1
#=GS A0A1Y5SYA9_9RHOB/55-111 AC A0A1Y5SYA9.1
#=GS A0A6S6QXZ8_9HYPH/144-198 AC A0A6S6QXZ8.1
#=GS A0A0Q8QLU0_9SPHN/47-103 AC A0A0Q8QLU0.1
#=GS A0A516H7F2_9PROT/41-97 AC A0A516H7F2.1
#=GS A0A1W2D859_9HYPH/171-227 AC A0A1W2D859.1
#=GS A0A0P0IIH4_BLAVI/51-107 AC A0A0P0IIH4.1
#=GS D5AMZ9_RHOCB/81-137 AC D5AMZ9.1
#=GS A0A7Y0HGW5_9PROT/108-162 AC A0A7Y0HGW5.1
#=GS A0A6M8ST71_9NEIS/81-137 AC A0A6M8ST71.1
#=GS A0A222E088_9RHOB/103-157 AC A0A222E088.1
#=GS A0A0U1NNA6_9RHOB/40-96 AC A0A0U1NNA6.1
#=GS A0A074JP28_9RHOB/112-168 AC A0A074JP28.1
#=GS V4Q8I5_9CAUL/78-133 AC V4Q8I5.1
#=GS A0A5B2TJN1_9PROT/21-77 AC A0A5B2TJN1.1
#=GS A0A2U8GVB0_9RHOO/29-84 AC A0A2U8GVB0.1
#=GS B9JZ95_ALLAM/118-171 AC B9JZ95.1
#=GS A0A1C2HBI5_9RHOB/44-100 AC A0A1C2HBI5.1
#=GS A0A1G7E8I0_9PROT/46-102 AC A0A1G7E8I0.1
#=GS A0A2A8CTJ2_9BACT/66-120 AC A0A2A8CTJ2.1
#=GS A0A838L4B3_9SPHN/97-151 AC A0A838L4B3.1
#=GS A0A5C6UN63_9SPHN/108-161 AC A0A5C6UN63.1
#=GS A0A840HWV8_9SPHN/38-94 AC A0A840HWV8.1
#=GS A0A397PIL5_9HYPH/51-107 AC A0A397PIL5.1
#=GS A0A0S3EZ36_9SPHN/98-152 AC A0A0S3EZ36.1
#=GS A0A1I4F5F8_9PROT/230-279 AC A0A1I4F5F8.1
#=GS A0A1H4Q955_9RHOB/167-221 AC A0A1H4Q955.1
#=GS A0A9J7B0B7_9PROT/112-164 AC A0A9J7B0B7.1
#=GS A0A2U2C8Y4_9RHOB/141-195 AC A0A2U2C8Y4.1
#=GS A0A563UCM8_9SPHI/327-382 AC A0A563UCM8.1
#=GS A0A1M6EE79_9FLAO/197-251 AC A0A1M6EE79.1
#=GS A0A370L8J5_9HYPH/111-165 AC A0A370L8J5.1
#=GS A0A6H9Y7S1_9PROT/26-77 AC A0A6H9Y7S1.1
#=GS A0A1S8D5S6_9PROT/155-210 AC A0A1S8D5S6.1
#=GS A0A1I0YGW6_9RHOB/65-121 AC A0A1I0YGW6.1
#=GS A0A850T7S7_9BACT/98-151 AC A0A850T7S7.1
#=GS A0A1R0MFZ3_CHRVL/90-146 AC A0A1R0MFZ3.1
#=GS A0A6M0HSM5_9HYPH/57-113 AC A0A6M0HSM5.1
#=GS B7RJ03_ROSS0/106-160 AC B7RJ03.1
#=GS A0A1G7DJM1_9RHOB/138-194 AC A0A1G7DJM1.1
#=GS A0A0D7DXB3_RHOPL/45-101 AC A0A0D7DXB3.1
#=GS A0A849KTL6_9RHOB/49-105 AC A0A849KTL6.1
#=GS A0A916WDS0_9HYPH/59-115 AC A0A916WDS0.1
#=GS A0A2T4JGQ8_9RHOB/135-189 AC A0A2T4JGQ8.1
#=GS A0A5B8LJS4_9SPHN/105-158 AC A0A5B8LJS4.1
#=GS A0A0P1GF82_9RHOB/30-86 AC A0A0P1GF82.1
#=GS A0A2Z6AE16_9SPHN/107-161 AC A0A2Z6AE16.1
#=GS U4V0C4_9RHOB/41-97 AC U4V0C4.1
#=GS A0A3T1CJ26_9SPHN/97-151 AC A0A3T1CJ26.1
#=GS A0A401FQ49_9BACT/623-677 AC A0A401FQ49.1
#=GS D4Z3H7_SPHIU/99-153 AC D4Z3H7.1
#=GS A0A4R7C9F0_9HYPH/114-169 AC A0A4R7C9F0.1
#=GS D5CND9_SIDLE/87-143 AC D5CND9.1
#=GS A0A316C031_PSESE/122-176 AC A0A316C031.1
#=GS A0A6M4B2A2_9SPHN/60-113 AC A0A6M4B2A2.1
#=GS A0A120CV32_HYPSL/38-94 AC A0A120CV32.1
#=GS A0A1Y5SV25_9RHOB/41-97 AC A0A1Y5SV25.1
#=GS A0A1G6Y7D5_9PROT/34-89 AC A0A1G6Y7D5.1
#=GS A0A2G1QV30_9HYPH/49-105 AC A0A2G1QV30.1
#=GS A0A5R8QF25_9HYPH/143-187 AC A0A5R8QF25.1
#=GS A0A061QGY6_9PROT/101-157 AC A0A061QGY6.1
#=GS A0A942E118_9HYPH/124-178 AC A0A942E118.1
#=GS A0A924DBX0_9BACT/103-152 AC A0A924DBX0.1
#=GS A0A0Q8IG31_9HYPH/33-86 AC A0A0Q8IG31.1
#=GS E0TE06_PARBH/122-176 AC E0TE06.1
#=GS X7F300_9RHOB/43-99 AC X7F300.1
#=GS A0A1H9GFP1_9RHOB/103-156 AC A0A1H9GFP1.1
#=GS A0A7G5LQT7_9HYPH/117-177 AC A0A7G5LQT7.1
#=GS A0A238JSL4_9RHOB/104-158 AC A0A238JSL4.1
#=GS A0A926R6F9_9PROT/92-144 AC A0A926R6F9.1
#=GS A0A1G9UKN5_9BURK/40-94 AC A0A1G9UKN5.1
#=GS N9WCZ6_9SPHN/34-90 AC N9WCZ6.1
#=GS A6ED94_9SPHI/395-444 AC A6ED94.1
#=GS A0A4T0UKK4_9NEIS/89-145 AC A0A4T0UKK4.1
#=GS A0A2S6N2L1_RHOGL/50-106 AC A0A2S6N2L1.1
#=GS A0A2M8QTR4_9SPHN/35-91 AC A0A2M8QTR4.1
#=GS A0A6G7ZMD5_9SPHN/97-151 AC A0A6G7ZMD5.1
#=GS A0A2N4YDN3_9RHOB/139-193 AC A0A2N4YDN3.1
#=GS A0A916Z630_9SPHN/101-159 AC A0A916Z630.1
#=GS A0A845M2Q4_9RHOB/108-161 AC A0A845M2Q4.1
#=GS A0A0S3PV86_9BRAD/51-107 AC A0A0S3PV86.1
#=GS A0A506UQ97_9PROT/119-175 AC A0A506UQ97.1
#=GS A0A5C1E4X2_9RHOO/106-162 AC A0A5C1E4X2.1
#=GS A0A8J7QLG2_9BACT/188-241 AC A0A8J7QLG2.1
#=GS A0A2Z2P4S0_9GAMM/190-237 AC A0A2Z2P4S0.1
#=GS A0A2M8MZ03_9RHOB/154-208 AC A0A2M8MZ03.1
#=GS A0A4T3F396_9SPHN/36-91 AC A0A4T3F396.1
#=GS A0A4R2NXT8_RHOAD/112-166 AC A0A4R2NXT8.1
#=GS A0A011MXJ3_9PROT/25-80 AC A0A011MXJ3.1
#=GS A0A368YGS7_9BACI/959-1011 AC A0A368YGS7.1
#=GS A0A1G6Y675_9SPHN/98-152 AC A0A1G6Y675.1
#=GS A0A2H6AYV5_UNCXX/116-170 AC A0A2H6AYV5.1
#=GS A0A7W9EUV0_9SPHN/100-154 AC A0A7W9EUV0.1
#=GS A0A1I4Z733_9NEIS/93-147 AC A0A1I4Z733.1
#=GS A0A1A6FKN7_9HYPH/54-110 AC A0A1A6FKN7.1
#=GS A0A3A3FQ19_9BURK/29-83 AC A0A3A3FQ19.1
#=GS A0A6B8LX12_9HYPH/122-168 AC A0A6B8LX12.1
#=GS A0A8J7IJH8_9RHOB/2-58 AC A0A8J7IJH8.1
#=GS A0A346YNA7_9HYPH/121-176 AC A0A346YNA7.1
#=GS A0A7W6BM99_9SPHN/49-105 AC A0A7W6BM99.1
#=GS A0A0C2BNY6_9BURK/29-84 AC A0A0C2BNY6.1
#=GS A0A846VQN1_9RHOB/138-192 AC A0A846VQN1.1
#=GS A0A1M5WJR4_9BACT/115-170 AC A0A1M5WJR4.1
#=GS A0A1L6J8Z3_9SPHN/99-153 AC A0A1L6J8Z3.1
#=GS A0A7W9A5R0_9CAUL/57-113 AC A0A7W9A5R0.1
#=GS A0A0N1B557_9HYPH/52-108 AC A0A0N1B557.1
#=GS A0A7W5ZVZ5_9SPHN/44-99 AC A0A7W5ZVZ5.1
#=GS A0A7W6J8C8_9HYPH/125-179 AC A0A7W6J8C8.1
#=GS A0A5J5GQ29_9RHOB/41-97 AC A0A5J5GQ29.1
#=GS A0A154WHB2_9PROT/49-105 AC A0A154WHB2.1
#=GS A0A7W6RE74_9PROT/77-133 AC A0A7W6RE74.1
#=GS A0A4Q7DH89_9PROT/138-195 AC A0A4Q7DH89.1
#=GS A0A3P5WCG8_9RHOB/114-168 AC A0A3P5WCG8.1
#=GS A0A922P0M6_9HYPH/126-181 AC A0A922P0M6.1
#=GS A0A846VQN1_9RHOB/75-131 AC A0A846VQN1.1
#=GS A0A323UWD8_9RHOO/30-84 AC A0A323UWD8.1
#=GS A0A239JF05_9SPHN/58-114 AC A0A239JF05.1
#=GS A0A562R206_9BURK/83-138 AC A0A562R206.1
#=GS A0A6L8VEI2_9RHOB/138-192 AC A0A6L8VEI2.1
#=GS A0A0D0PH51_9RHOB/165-219 AC A0A0D0PH51.1
#=GS A0A6P1YUV6_9HYPH/417-469 AC A0A6P1YUV6.1
#=GS A0A7H0LM46_9SPHN/106-159 AC A0A7H0LM46.1
#=GS A0A1L7I3R7_9FLAO/194-248 AC A0A1L7I3R7.1
#=GS A0A327M440_9PROT/258-314 AC A0A327M440.1
#=GS A0A220W3T3_9SPHN/33-89 AC A0A220W3T3.1
#=GS A0A2S1LL60_9FLAO/192-246 AC A0A2S1LL60.1
#=GS A0A964TJ61_9RHOB/75-131 AC A0A964TJ61.1
#=GS A0A564WD70_9PROT/73-129 AC A0A564WD70.1
#=GS A0A4P6MN62_9RHOB/120-174 AC A0A4P6MN62.1
#=GS A0A545B967_9RHOB/70-126 AC A0A545B967.1
#=GS A0A7X6FX24_9RHOB/41-97 AC A0A7X6FX24.1
#=GS A0A0M7B634_9RHOB/172-227 AC A0A0M7B634.1
#=GS A0A7W7YV71_9HYPH/117-171 AC A0A7W7YV71.1
#=GS A0A2V4MR19_9RHOB/38-94 AC A0A2V4MR19.1
#=GS A0A2T1HQG2_9HYPH/115-169 AC A0A2T1HQG2.1
#=GS A0A4Y6UC28_9PROT/245-295 AC A0A4Y6UC28.1
#=GS A0A3N1WQM1_9BURK/39-94 AC A0A3N1WQM1.1
#=GS A0A975IX61_9CAUL/10-66 AC A0A975IX61.1
#=GS A0A1H4CNP2_9RHOB/76-132 AC A0A1H4CNP2.1
#=GS A0A2T0WC99_9RHOB/108-161 AC A0A2T0WC99.1
#=GS A0A7W8EMD3_9HYPH/85-141 AC A0A7W8EMD3.1
#=GS A0A8J3DMB8_9HYPH/121-175 AC A0A8J3DMB8.1
#=GS A0A075R9G4_BRELA/100-155 AC A0A075R9G4.1
#=GS A0A1M5ITQ3_9HYPH/134-188 AC A0A1M5ITQ3.1
#=GS A0A0W7Z1Q1_9BURK/18-73 AC A0A0W7Z1Q1.1
#=GS H6SRN1_PARPM/98-154 AC H6SRN1.1
#=GS A0A2T5G077_9SPHN/98-152 AC A0A2T5G077.1
#=GS A0A7X9ZMN8_9SPHN/100-154 AC A0A7X9ZMN8.1
#=GS A0A845AWX9_9SPHN/108-162 AC A0A845AWX9.1
#=GS A0A371XAI2_9HYPH/169-225 AC A0A371XAI2.1
#=GS A0A6L6J893_9RHOB/75-131 AC A0A6L6J893.1
#=GS A0A251X1T6_9RHOB/48-104 AC A0A251X1T6.1
#=GS A0A1Y5T825_9RHOB/41-97 AC A0A1Y5T825.1
#=GS A0A1B3LMI8_9PROT/90-147 AC A0A1B3LMI8.1
#=GS Q21ES5_SACD2/44-98 AC Q21ES5.1
#=GS A9BZM5_DELAS/40-94 AC A9BZM5.1
#=GS A0A1Q8YAF5_9BURK/37-92 AC A0A1Q8YAF5.1
#=GS A0A165F256_9NEIS/90-146 AC A0A165F256.1
#=GS A0A4S2HAT9_9PROT/103-156 AC A0A4S2HAT9.1
#=GS A0A934HQ80_9RHOB/111-165 AC A0A934HQ80.1
#=GS A0A6N7LHC9_SINTE/121-175 AC A0A6N7LHC9.1
#=GS A0A5M6ZIL5_9PROT/103-156 AC A0A5M6ZIL5.1
#=GS A0A7X2FSQ1_9PROT/54-110 AC A0A7X2FSQ1.1
#=GS A0A2T7FYB5_9RHOB/54-110 AC A0A2T7FYB5.1
#=GS A0A1I6YXU8_9RHOB/111-165 AC A0A1I6YXU8.1
#=GS A0A0P6VX19_9HYPH/39-95 AC A0A0P6VX19.1
#=GS A0A318T571_9HYPH/62-118 AC A0A318T571.1
#=GS A0A0Q5W9Z8_9HYPH/42-98 AC A0A0Q5W9Z8.1
#=GS A0A6I4T6F9_9SPHN/96-150 AC A0A6I4T6F9.1
#=GS A0A327KRP9_9HYPH/96-150 AC A0A327KRP9.1
#=GS A0A4U8V4H3_9BURK/41-95 AC A0A4U8V4H3.1
#=GS A0A254R3Z9_9RHOB/29-85 AC A0A254R3Z9.1
#=GS A0A2S9JCW1_9HYPH/48-104 AC A0A2S9JCW1.1
#=GS L0ERE9_LIBCB/77-133 AC L0ERE9.1
#=GS A0A1L9BUD3_9RHOB/25-81 AC A0A1L9BUD3.1
#=GS A0A0Q7ENJ1_9HYPH/126-189 AC A0A0Q7ENJ1.1
#=GS S0FTF4_9BACT/38-92 AC S0FTF4.1
#=GS A0A0Q6ERB7_9HYPH/60-116 AC A0A0Q6ERB7.1
#=GS A0A1L3GM57_9BACT/82-143 AC A0A1L3GM57.1
#=GS A0A0M4LSH6_9HYPH/121-175 AC A0A0M4LSH6.1
#=GS A0A1Q9CRR5_SYMMI/1029-1078 AC A0A1Q9CRR5.1
#=GS A0A516IT19_9SPHN/101-150 AC A0A516IT19.1
#=GS A0A2R8BXS4_9RHOB/40-96 AC A0A2R8BXS4.1
#=GS A0A2T4JCX3_FUSBL/120-173 AC A0A2T4JCX3.1
#=GS A0A1H8EWU3_9SPHN/37-93 AC A0A1H8EWU3.1
#=GS A9HEH6_GLUDA/236-291 AC A9HEH6.1
#=GS Q2NA56_ERYLH/34-90 AC Q2NA56.1
#=GS A0A5B8S0K0_9BURK/19-73 AC A0A5B8S0K0.1
#=GS A0A1M5ITQ3_9HYPH/67-122 AC A0A1M5ITQ3.1
#=GS A0A1V1PEP3_9BACT/24-79 AC A0A1V1PEP3.1
#=GS A0A518UAJ9_9PROT/30-85 AC A0A518UAJ9.1
#=GS A0A1H8PRF7_9BURK/90-146 AC A0A1H8PRF7.1
#=GS A0A4U1L262_9SPHN/34-90 AC A0A4U1L262.1
#=GS A0A4Y9ENJ1_9SPHN/100-153 AC A0A4Y9ENJ1.1
#=GS A0A3S2XML0_9RHOB/42-98 AC A0A3S2XML0.1
#=GS A0A0D5LN21_MAREN/129-176 AC A0A0D5LN21.1
#=GS A0A0H3CDB6_CAUVN/117-171 AC A0A0H3CDB6.1
#=GS A0A558QZE6_9SPHN/96-150 AC A0A558QZE6.1
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//
