#=GF ID SOR
#=GF AC PF07682.14
#=GF DE Sulphur oxygenase reductase
#=GF AU Kletzin A;
#=GF AU Studholme DJ;0000-0002-3010-6637
#=GF SE [4]
#=GF GA 25.00 25.00;
#=GF TC 25.00 27.30;
#=GF NC 24.40 24.30;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF CL CL0032
#=GF RN [1]
#=GF RM 2493451
#=GF RT Coupled enzymatic production of sulfite, thiosulfate, and
#=GF RT hydrogen sulfide from sulfur: purification and properties of a
#=GF RT sulfur oxygenase reductase from the facultatively anaerobic
#=GF RT archaebacterium Desulfurolobus ambivalens.
#=GF RA Kletzin A;
#=GF RL J Bacteriol 1989;171:1638-1643.
#=GF RN [2]
#=GF RM 11111027
#=GF RT Cloning and heterologous expression of a sulfur
#=GF RT oxygenase/reductase gene from the thermoacidophilic archaeon
#=GF RT Acidianus sp. S5 in Escherichia coli.
#=GF RA He Z, Li Y, Zhou P, Liu S;
#=GF RL FEMS Microbiol Lett 2000;193:217-221.
#=GF RN [3]
#=GF RM 12664265
#=GF RT Purification and properties of the sulfur oxygenase/reductase
#=GF RT from the acidothermophilic archaeon, Acidianus strain S5.
#=GF RA Sun CW, Chen ZW, He ZG, Zhou PJ, Liu SJ;
#=GF RL Extremophiles 2003;7:131-134.
#=GF RN [4]
#=GF RM 15030315
#=GF RT The sulphur oxygenase reductase from Acidianus ambivalens is a
#=GF RT multimeric protein containing a low-potential mononuclear
#=GF RT non-haem iron centre.
#=GF RA Urich T, Bandeiras TM, Leal SS, Rachel R, Albrecht T, Zimmermann
#=GF RA P, Scholz C, Teixeira M, Gomes CM, Kletzin A;
#=GF RL Biochem J 2004; [Epub ahead of print]
#=GF DR INTERPRO; IPR011661;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC The sulphur oxygenase/reductase (SOR) of the thermo-acidophilic
#=GF CC archaeon Acidianus ambivalens is an unusual enzyme consisting of
#=GF CC 24 identical subunits arranged in a perfectly symmetrical hollow
#=GF CC sphere and containing a mononuclear non-heme iron centre
#=GF CC (personal communication: A. Kletzin). At 85 degrees C in vitro,
#=GF CC elemental sulphur is oxidised to sulphite, thiosulphate and
#=GF CC hydrogen sulphide with no external cofactors needed. The
#=GF CC proposed equation is: 4S + O2 + 4 H2O ---> 2 HSO3- + 2 H2S + 2
#=GF CC H+.
#=GF SQ 31
#=GS A0A6F8ZGR9_9FIRM/3-301 AC A0A6F8ZGR9.1
#=GS W7KXF0_9CREN/3-303 AC W7KXF0.1
#=GS A0A510DRE6_9CREN/3-303 AC A0A510DRE6.1
#=GS L0DXR4_THIND/8-328 AC L0DXR4.1
#=GS A0A1W1WDM4_SULTA/3-301 AC A0A1W1WDM4.1
#=GS A0A031LS77_9CREN/3-303 AC A0A031LS77.1
#=GS A0A191ZEW9_9GAMM/5-309 AC A0A191ZEW9.1
#=GS A0A6F8ZDC7_9FIRM/3-301 AC A0A6F8ZDC7.1
#=GS A0A1C2FZF0_9GAMM/15-316 AC A0A1C2FZF0.1
#=GS Q972K4_SULTO/3-303 AC Q972K4.1
#=GS Q972K4_SULTO/3-303 DR PDB; 6M3X O; 3-303;
#=GS Q972K4_SULTO/3-303 DR PDB; 6M35 B; 3-303;
#=GS Q972K4_SULTO/3-303 DR PDB; 6M3X F; 3-303;
#=GS Q972K4_SULTO/3-303 DR PDB; 6M3X T; 3-303;
#=GS Q972K4_SULTO/3-303 DR PDB; 6M3X U; 3-303;
#=GS Q972K4_SULTO/3-303 DR PDB; 6M35 D; 3-303;
#=GS Q972K4_SULTO/3-303 DR PDB; 6M3X X; 3-303;
#=GS Q972K4_SULTO/3-303 DR PDB; 6M3X N; 3-303;
#=GS Q972K4_SULTO/3-303 DR PDB; 6M3X E; 3-303;
#=GS Q972K4_SULTO/3-303 DR PDB; 6M35 E; 3-303;
#=GS Q972K4_SULTO/3-303 DR PDB; 6M3X J; 3-303;
#=GS Q972K4_SULTO/3-303 DR PDB; 6M3X I; 3-303;
#=GS Q972K4_SULTO/3-303 DR PDB; 6M3X L; 3-303;
#=GS Q972K4_SULTO/3-303 DR PDB; 6M35 C; 3-303;
#=GS Q972K4_SULTO/3-303 DR PDB; 6M3X K; 3-303;
#=GS Q972K4_SULTO/3-303 DR PDB; 6M3X Q; 3-303;
#=GS Q972K4_SULTO/3-303 DR PDB; 6M3X M; 3-303;
#=GS Q972K4_SULTO/3-303 DR PDB; 6M35 H; 3-303;
#=GS Q972K4_SULTO/3-303 DR PDB; 6M35 G; 3-303;
#=GS Q972K4_SULTO/3-303 DR PDB; 6M3X P; 3-303;
#=GS Q972K4_SULTO/3-303 DR PDB; 6M3X G; 3-303;
#=GS Q972K4_SULTO/3-303 DR PDB; 6M3X S; 3-303;
#=GS Q972K4_SULTO/3-303 DR PDB; 6M3X H; 3-303;
#=GS Q972K4_SULTO/3-303 DR PDB; 6M3X V; 3-303;
#=GS Q972K4_SULTO/3-303 DR PDB; 6M3X B; 3-303;
#=GS Q972K4_SULTO/3-303 DR PDB; 6M3X C; 3-303;
#=GS Q972K4_SULTO/3-303 DR PDB; 6M3X R; 3-303;
#=GS Q972K4_SULTO/3-303 DR PDB; 6M35 A; 3-303;
#=GS Q972K4_SULTO/3-303 DR PDB; 6M35 F; 3-303;
#=GS Q972K4_SULTO/3-303 DR PDB; 6M3X W; 3-303;
#=GS Q972K4_SULTO/3-303 DR PDB; 6M3X A; 3-303;
#=GS Q972K4_SULTO/3-303 DR PDB; 6M3X D; 3-303;
#=GS A0A4R1F918_9GAMM/14-304 AC A0A4R1F918.1
#=GS A0A2U9IE15_9CREN/3-303 AC A0A2U9IE15.1
#=GS S0ATP9_FERAC/3-301 AC S0ATP9.1
#=GS Q6L0W6_PICTO/3-301 AC Q6L0W6.1
#=GS A0A179BLA1_ACIFR/4-306 AC A0A179BLA1.1
#=GS G8TY32_SULAD/3-301 AC G8TY32.1
#=GS S7U334_DESML/1-56 AC S7U334.1
#=GS A0A1A6C2F7_9GAMM/5-307 AC A0A1A6C2F7.1
#=GS L0DTB9_THIND/24-315 AC L0DTB9.1
#=GS A0A2I1DKN4_9PROT/4-306 AC A0A2I1DKN4.1
#=GS A0A2S3QF68_9FIRM/3-301 AC A0A2S3QF68.1
#=GS A0A1W1WET7_SULTA/3-301 AC A0A1W1WET7.1
#=GS A0A2U3D831_9BACL/3-301 AC A0A2U3D831.1
#=GS F4B4D5_ACIHW/1-294 AC F4B4D5.1
#=GS C7LRC9_DESBD/10-306 AC C7LRC9.1
#=GS O66762_AQUAE/8-332 AC O66762.1
#=GS A0A0Q1B5C6_9ARCH/3-301 AC A0A0Q1B5C6.1
#=GS A0A1P8UIF1_9GAMM/5-307 AC A0A1P8UIF1.1
#=GS A0A656HKX2_THINJ/1-77 AC A0A656HKX2.1
#=GS A0A094JY80_9DELT/3-305 AC A0A094JY80.1
#=GS D0L035_HALNC/5-309 AC D0L035.1
#=GS D0L035_HALNC/5-309 DR PDB; 6QPA N; 5-309;
#=GS D0L035_HALNC/5-309 DR PDB; 6QPA P; 5-309;
#=GS D0L035_HALNC/5-309 DR PDB; 6QPA M; 5-309;
#=GS D0L035_HALNC/5-309 DR PDB; 6QPA T; 5-309;
#=GS D0L035_HALNC/5-309 DR PDB; 6QPA Y; 5-309;
#=GS D0L035_HALNC/5-309 DR PDB; 6QPA D; 5-309;
#=GS D0L035_HALNC/5-309 DR PDB; 6QPA J; 5-309;
#=GS D0L035_HALNC/5-309 DR PDB; 6QPA V; 5-309;
#=GS D0L035_HALNC/5-309 DR PDB; 6QPA W; 5-309;
#=GS D0L035_HALNC/5-309 DR PDB; 6QPA I; 5-309;
#=GS D0L035_HALNC/5-309 DR PDB; 6QPA G; 5-309;
#=GS D0L035_HALNC/5-309 DR PDB; 6QPA L; 5-309;
#=GS D0L035_HALNC/5-309 DR PDB; 6QPA E; 5-309;
#=GS D0L035_HALNC/5-309 DR PDB; 6QPA B; 5-309;
#=GS D0L035_HALNC/5-309 DR PDB; 6QPA C; 5-309;
#=GS D0L035_HALNC/5-309 DR PDB; 6QPA F; 5-309;
#=GS D0L035_HALNC/5-309 DR PDB; 6QPA H; 5-309;
#=GS D0L035_HALNC/5-309 DR PDB; 6QPA K; 5-309;
#=GS D0L035_HALNC/5-309 DR PDB; 6QPA U; 5-309;
#=GS D0L035_HALNC/5-309 DR PDB; 6QPA O; 5-309;
#=GS D0L035_HALNC/5-309 DR PDB; 6QPA Z; 5-309;
#=GS D0L035_HALNC/5-309 DR PDB; 6QPA R; 5-309;
#=GS D0L035_HALNC/5-309 DR PDB; 6QPA Q; 5-309;
#=GS D0L035_HALNC/5-309 DR PDB; 6QPA A; 5-309;
A0A6F8ZGR9_9FIRM/3-301 ...n-PYIAVNTAKVCNRPESFEAFQRVGPKVCMVTANNSGFLGFQNHVQVGVFPMGGRYGGAQMDMHDK...L.............NPLGIMQYTMWKRWEDHEQMHVDQFDSIFRLCSQCLGMVVEGPWEPVYEIVAHKMPDTVGMTDVPAALGAAFAAGQPV..--PPVALPYGQRIIAHSEHLIIPGLEKEFEDAIVPVMEAFEK.APGFLGYMVMKQIGASAIGSMQLVPEGLHQALQTLGDYP.PRVKEGNF........QLVQAKSTPAEYVVHMEWADLNAAMFGISRVAINHEVRTLHD-RALKTVLR.GPYVTLWNPMMEDTSWR...............
W7KXF0_9CREN/3-303 ...r-PYVAINMADLKNEPKTFEMFASIGPKVCMVTARHPGFVGFQNHIQIGVVPFGQRYGGAKPDMTKE...S.............STVRVLQYTFWRHWKDHEEMHRQNWSYLFRLCYSCASQMVWGPWEPIYEIVYADMPINTEMTDFTAVVGKKFAEGKPL..EIPVISQPYGKRVVAFSEHSVIPGKEKQFEEAVVKTLKLLKK.APGFLGAMVLKEIGVSGIGSFQFGAKGFHELLESPGSIE.PDPNNVQY........QVTEAKPTPQQYVVHVEWANADALQFGMGRVLLEPETRRTHD-EALDTLVY.GPYIRILSPVMEGTFWR...............
A0A510DRE6_9CREN/3-303 ...k-PYVAINQVIVKNEPKTFEMFQSVGPKVCMTTARHKGFVGFQNHIEIGVVPMGTRYGAAKMDMLKE...N.............TTMGLFQYTMWKDWKDHEEMHKQNWSSLFRLCYSCMSQVVWGPWEPLYEVTMADMPLNTEMTDFTVMVGQKFASGDAL..SLPPISQPYGKRVVTYGEHVVKEGMEKEFEETLGKLLPMFKR.APGFLGYMVLKEIGASALGSLQLSAKSWHQMLESANGMD.VPDPNGNF........APEQARNKPQRYVVHMEWSSTDAAMFGLGRVFLSPEYREIHD-QIVDTLVY.GPYIRVLNPVMEGSFWR...............
L0DXR4_THIND/8-328 ...g-AALAINQAAVANDPQTFEKMGHIGPKVCLTTANEPGFLGFHAFLQTGTHPLGGRFGAAQVVTADS...Leavies.phnlrlNPLNLWQYTLWEDAESHERMHYEQYDRIFELCAGCLDMVVDGPWEPVYTIAEANMPPIIGMTDVPRVMGQAFARQQEP..--PKVRLAM-RRLVALGEHHVREGHEQAFLEGAVKTLELLQEhAPGMIGWMILEKQGEAALSTFQLEPPAFWESLQTLGANP.PKSRRTNFgefgkdytSPPIPIGGPKEYQVHMEWESPDALTFGLALTGVNPKLRRIHDEGVLAHLAKlPPYYRVFAPAMEDMIFF...............
A0A1W1WDM4_SULTA/3-301 ...r-PYIAINDAKVVNAESSFQAFQQVGPKVCMVTANHPGFVGFQNHVQIGVFPMGGRYGGAKMDMHEE...L.............NPIGIRQYTMWKRWEDHEEMHYQQFDSIFRLCSSCLGMVVEGPWEDVYEIVSSDLPEVIAMTDVPSKLGAAFMAGQQP..--APVAMPYGQRVIAGSDHYIIPGREQEFETAITDLMKMFQK.APGFLGYMVLKQIGASAIGSFQLQPEGIHQALQTLGDNP.PKNKEGNF........KLIEAKKTPTKYLVHMEWMDLNSAMFGISRVVINGRYRAQHD-KALATLVQ.GPYVTLWSPMMEDTSWR...............
A0A031LS77_9CREN/3-303 ...k-PYVAINMADLRNEPKTFEMFASVGPKVCMVTARHPGFVGFQNHIQIGVLPFGTRYGGAKMDMTKE...S.............STVRVLQYTFWKDWKDHEEMHRQNWSYLFRLCFSCASQMIWGPWEPLYEITYANMPINTEMTDFTEVVGRKFAEGKPM..EIPAISQPYGKRVVAYAEHTVKPGKEKQFEDAIIKTLEMFKR.APGFLGAMVLKEIGVSAIGSFQFGSKGLHELLETPGSLE.PDPNSTIF........EPPEAKPTPPNYIVHVEWADQDALQFGMGRVLLSPEYRAIHD-QALDTLIY.GPYIRIINPIMEGTFWR...............
A0A191ZEW9_9GAMM/5-309 ...n-PIIAINMTKIANRPDSYETMMKVGPKVCITTASHPGFLGFEQMLQTGIHPMAGRYGGGAIDMRET...L.............NPMGMFQYTVWKDVRAHEEMHHDNFKEIFELCGSCLDMVIEGPWEPYFEVIQSDLPQIMSITDVPQVLGDSFAQQKQV..--PKVALAS-QRAVVIGDHWVMHGHEEDFEKGAVETLQWMKEnVPGMIGWMVMKQFGVSAIGSFQLDPEGAMKAVSTLGANP.PEY-NTNYgne..ihdKPPIPGQTPVQYLVHIEWESPDHAHMGLGHAMVDYELRQIHNNGVLAHLDK.GPYYMIFAPMMEQGVWR...............
A0A6F8ZDC7_9FIRM/3-301 ...k-PYIAVNEVRLVNGPESFRRFEIIGPKMCMATANHGGFVGFQNHFPIGVFPMGGRYGGAKLDMRES...L.............NPLPVRQYTFWKDWRDHDQMHVDNFDTIFRLCSGCLDLMIDGPWEPIYEIVSHDLPENIGLTDVPAKLGAAFMAGQAV..--PSVALPYGQRVVATSDHTIIPGREQDFETAIEQLMQAFKE.APGFLGYMVLRQMGVSAIGSLQLKPAALHQALQTTGDYP.PRIKEGNF........ATPEGKATPAQYVVHMEWADMNTAVMGISRVVINTRFRALHD-PVLDTLLK.GPYIQLWSPQMEDTSWR...............
A0A1C2FZF0_9GAMM/15-316 ...n-PVIAINMARISNRPENHEIMHKVGPKVCITTATHPGFLGFDQLLQVGIHPMAGRYGGGALDMRET...L.............NPISMFQYTVWKDAKSHEEMHYLQFDTIYELCSHCLAMVVEGPWEPVYEIVASDLPPSIGLTDVPALMMARAASQQPV..--PKVALPM--RTIAVGDHSVMHGHETDFEQGVRDTMAWLMGhAPGMLGWMLLKQIGVSAIGSFQLDPAGMTKA--TLGANP.PRY-ATNYgdk..pldHPPIPAATPAQYFVHMEWEAPELAHQGLGKVLVNVEARRIHDHGVLAHINR.GPYYMLFASMMEEGTWR...............
Q972K4_SULTO/3-303 ...k-PYVAINMVEVRNDPKTLELFGKVGPKVCMVTARHPGFVGFQNHVQIGVVPLGTRWGGAKMEMSQE...M.............HSLMLMQYTFWKNWKDHEEMHKQNWANLFRLCLQCADQMIWGPYEPLYEIVYANMPLNTEMTDFTVMVGKKFAAGEAV..SIPPISQPYGKRVVAFGEHIVKEGLENQFEEYAIKTLEAFRS.APGFLGGMILKEIGVSPLGSLQLNAKGFHQILETANGMD.VPEPVTIY........EAPEFRNRPQRYIVHTEWSDTNALMFGLGRVLIYPEVRQIHD-KVLDTLVY.GPYIRVLNPMMEGTYWR...............
#=GR Q972K4_SULTO/3-303 SS ...---EEEEEEEEEE-SHHHHHHHHHTHHHHHHHHTTSTTEEEEEEEEEEEE--TTTTTTT--SS-TTT...-.............SEEEEEEEEEESSHHHHHHHHHHTHHHHHHHHGGGTTTEEEEEE-EEEEEEEEE---B--TTSHHHHHHHHHHTT-GG..G----B--SSSSEEEEEEEEE-TT-HHHHHHHHHHHHHHGGG.STTEEEEEEEEEEEE-TTTTT---HHHHHHHHH-STTSS.------S-........-GGGS--BSEEEEEEEEESSHHHHHHHHTHHHHSHHHHHHHH-HHHTTEEE.EEEEEEEEEEEEETTHH...............
A0A4R1F918_9GAMM/14-304 ...p-LYVAINKVLVKNDPNLMRMMKQASAKMCLATSLTPGFSGFDLMKQVGSCPMGMRWG-ASSDMSDE...L.............SHIWIDQITYWDSWQAHEDFHETFEDVVVDTCARCGDVLLEGPEEPVYRVVKSDLPSLISMTQWLR----KSAEGKAD..---GYAVDSGNSVTVMATHKIKPGAEAEFEEGEIATMEGLKA.TSGMVGYQILKRIGISTLGSGHATVESIMEDMKNS--SG.SKLKRTA-........EVWEGYTIPAEYLVMVEWDSLGAAQAGMPHVNVKPELLFQHGPKVLNNCLH.MPTVRMSDSMFREQS--nr.............
A0A2U9IE15_9CREN/3-303 ...k-PYIAINMADLKNEPKTFEMFSAVGPKVCMVTARHPGFVGFQNHVQIGVLPFGERFGGAKMDMTKE...S.............STVRVLQYTMWKDWKDHEEMHRQNWSYLFRLCYSCASQMVWGPWEPIYEIKYADMPINTEMTDFTAVVGKKFAEGKPL..EIPVISQPYGKRVVAFGEHTVIPGKEKQFEDAIIKTLEMFKR.APGFLGAMLLKEIGVSGIGSFQFGSKGFHQLLESPGSLE.PDPNNVMY........QVPEAKPTPPQYIVHVEWANLDALQFGMGRVLLSPEYREVHD-EALDTLIY.GPYIRIINPVMEGTFWR...............
S0ATP9_FERAC/3-301 ...k-PYVAINEVEMLNNDTTMQMFQQVGPKVCQVTARHPGFVGFQNHMQFGIIPMGTRWGGGSMDMTK-...M.............DTMNVYQYTMWKSIKDHEDMHRENFSSIFRLCSSCLSQVVYGPWEPLYEIVDASMPLNTEMADFTTMFGKKFAAGDPA..GVPPISMPYGQRTIALSEHTVKKDKEKEFESTIVEVMKDFEK.APGFLGYMILKEVGVSAVGSFQLKSKGIHETLESGGEVP.-TQQEGSF........KPEEARPTPPEYKVHMEWASPNDAMFGIGRVLFAHPAREIHD-KVLDTLIR.GPYIRLLNPMMEGTTWR...............
Q6L0W6_PICTO/3-301 ...k-PYVAINIVEMLNNETTMNMFQQVGPKVCMVTARHPGFVGFQNHVQFGVIPLGTRYGGASMDMTK-...M.............STMNVYQYTMWKNIKDHEDMHRENFSSIFRLCSSCLSQVVYGPWEPLFEIVDADMPLNTDMMDFTVMFGKKFAAGDPS..GVPPISQPYGRRTIALSEHTVKKGMEKDFESNIVEVMKDFRN.APGFLGYMILKEVGVSAVGSFQLKSQGIHEALESNGEV-.PQHQEGAF........SYEEARPTPPEYFVHMEWATPQDAQFGIARVLFKHETRVLHD-KVLDTLIK.GPYIRLLNPMMEGTSWR...............
A0A179BLA1_ACIFR/4-306 ...n-PIIAINQAKIFNRPESYEIMMKVGPKVCITTANHPGFLGFEQLIQTGIHPMAGRYGGGSIDMRET...L.............NPIAMYQYTVWKDVHSHEEMHHDNFDTIYELCGSCLDMVIEGPWEVYYEIIKSDLPPIMGITDVPTILGDAFAKQQPV..--PKVALAE-QRAITVGDHWVMKGHEQGFEEGVIKTLEWLKAsVPGMIGWMILKQTGASAIGSFQLDPEGMLKA--TLGANP.PKY-NTNYgsk..iptQPPIPAQTPAQYLIHMEWESPAHAHTGLGYVMVDYDLRQIHNNGVLQHLDK.GPYYMFFAPMMEQGMWR...............
G8TY32_SULAD/3-301 ...v-PYIAVNKARVLNAPSSFETFTSVGPKVCMVTANHEGFVGFQNHVQVGVFPMGGRYGAAKMDMHEE...L.............NPIGIVQYTMWRHWEDHEAMHYENFDSIFRLCSQCLNMVVEGPWEPLYEIVAHDLPENVSMTDVPAALGAAWMAGQPV..--PAVSLPYGQRIVAASDHTVIPGREKDFEQAIVDVMTAFKK.APGFLGYMVMKQIGASAIGAMQLTPQGIHQALQTRGDNP.PRDKEGNF........QPMQAHSSPQEYVVHMEWADMNSAMMGISRVVVNHKMRMIHD-RVLETVLK.GPYVTLWNPIMEDTSWR...............
S7U334_DESML/1-56 ....--------------------------------------------------------------MENA...L.............NPVRSYQYIMWKRWQDHDEFHEQQFSRIFELCTSCLGMVVEGPWEPVYR-----------------------------..------------------------------------------.---------------------------------------.--------........---------------------------------------------------.-----------------ah.............
A0A1A6C2F7_9GAMM/5-307 ...n-PIIAINMSKVSNTPDSFDTMMKVGPKVCITTASHPGFLGFEQLIQTGIHPMAGRYGGGSVDMRET...L.............NPIGMYQYTVWQDVRSHEEMHHDNFKEIYELCGSCLDMVIEGPWEPYFEVVRSDLPQIVSMTDVPQALGNAFAKEEQV..--PKVALAS-QRAVVVGDHWVMHGHETDFEKGAFQTLEWMKEnVPGMIGWMVLKQFGVSAIGSFQLDPEGMLKA--TLGANP.PDY-NTNYgda..ihdQPPIPPQTPTQYLVHMEWESPEHAHMGLGHAMVDYELRKIHNDGVLAHLDR.GPYYAFFAPMMEQGLWR...............
L0DTB9_THIND/24-315 ...p-LYVAINRVLVENNPNLMRMMRQASSEMCLATALTPGFRGFDLMRQTGSCPMGMRWG-ASTDMTQE...L.............SHIWIDQFTYWDTLDAHEEFHETFEDVVVTACDKCGNVLLDGPEEPVYRIVASHLPRLVSLNQFEQ------ARAQER..DIGHLAVDSGETVTVLATHIVRPGKEAEFEEGEIRTMELLRE.SNGMIGYQILKRVGISTLGSGHATVESIMERMK---DTPdAKLQRTA-........EVWEGYTIPAEYLVMVEWESLHAAQRGMPHVNVKPDILFVHGPKVFNNCVR.MPTVRMAVSMFAEQTYR...............
A0A2I1DKN4_9PROT/4-306 ...n-PIIAINQSKVANRPESYATMMKVGPKVCITTASHPGFLGFEQLLQTGIHPMAGRYGGGAVDMHET...L.............NPISMFQYTVWKDVKSHEEMHHENFKEIFELCGSCLDMVIEGPWEPYYEVVRSDLPLIMGMTDIPAALGQSFAEQKPV..--PKVALSA-KRSIAIGDHWVMDGHEEDFEKGAIETLSWMKEnVPGMIGWMIMKQFGVSAIGSFQFDPKGMLKA--TLGANP.PEY-NTNYgsq..vpdKPLIPGQKPTQYLVHMEWESPEHAHMGIAHAMLDYELRQIHNEGVLAHLDK.GPYYMLFGPMMEQGQWR...............
A0A2S3QF68_9FIRM/3-301 ...r-PIVAINDAKIVNQPSSFNMFESVGPKVCMVTANHSGFVGFQNHVQIGVFPMGGRYGAAKMDMHAE...L.............NPLGIRQYTMWKNWQDHEEMHYEQFDSIFRLCANCLGMIIEGPWENLYEITSSDLPDNMAMTDVPSRLGAAFMAGQTP..--DAVSMPYGQRVIAGSDHRIIPGREQEFETAIEDLMQMFKK.APGFLGYMVLKQIGASAIGSFQLNPEGLHQALQTTGEYP.PRNKEGNF........QLLDAKATPTEYIVHMEWQDLNSAMMGISRVVINTKYRAQHD-RVLATLVQ.GPYVTLWNPLMEDTSWR...............
A0A1W1WET7_SULTA/3-301 ...k-PYIAINSAKVANHPDSFRLFESVGPKVCMVTANHSGFVGFQNHVQIGVFPMGGRYGGAEMDMRQT...L.............NPLGIRQYTMWKRWEDHEEMHVQQFDSIFRLCSSCLGMVIEGPWEPIYEIVSSDLPDNMALTDVPATLGSQFMAGQPV..--PPVSMPYGQRVIAASEHTIIPGMENAFESAIEDLMQMFKK.APGFLGYMVLKQIGASAIGSLQLTPEGIHQALQTLGDYP.PRAQSGNF........ETLQAAPTPKEYVVHMEWQDLATAQFGISRVVVNTRYRAQHD-KVLKTLIR.GPYVTLWSPMMEDTSWR...............
A0A2U3D831_9BACL/3-301 ...n-PYIAISKAKVVNAPESFAAFESVGPKVCMVTANHNGFLGFQNHVQVGVFPMGGRFGGAKMDMHHE...L.............NPIGIAQYTMWKRWEDHEEMHMEQFDSIFRLCSRCLGMVVEGPWEDVYEIVAHDMPENVGMTDVPAVLGASFMAGEEM..--PPVSLPYGQRVIAAGEHAVIPGKEEEFEQAVGQVMKQFKK.APGFLGYMIMRQIGASAVGSFQLEPDGIHQALQTLGDNP.PSSRAGNF........QLMQAEKKPTAYIVHMEWADMKSAMFGISRVVVNHKVKAIHD-KALATLVQ.GPYITLWNPLMEDTSWR...............
F4B4D5_ACIHW/1-294 ....-------MAELKNEPKTFEMFASVGPKVCMVTARHPGFVGFQNHIQIGILPFGNRYGGAKMDMTKE...S.............SSVRVLQYTFWKDWKDHEEMHRQNWSYLFRLCYSCASQMIWGPWEPIYEIIYANMPINTEMTDFTAVVGKKFAEGKPL..DIPVISQPYGKRVVAFAEHSVIPGKEKQFEDAIVRTLEMLKK.APGFLGAMVLKEIGVSGIGSMQFGAKGFHQVLENPGSLE.PDPNNVMY........SVPEAKNTPQQYIVHVEWANTDALMFGMGRVLLYPELRQVHD-EVLDTLVY.GPYIRILNPMMEGTFWR...............
C7LRC9_DESBD/10-306 ...p-IYVALNMSKVVNNEESFDLMHKVGPRVCITTATHPGFLGFMANIQTGILPLAGRYGGGSTHMENA...L.............NPVRNYQYTMWKHWKDHDEFHEKQFSRIFELCTSCLEMVVEGPWEPVYSVIHAKMPTVRSMGQIAD-LGKDFVQQKDF..----IRFATPQRCVAIGEHTVAPGKEKAFEKGAIETMEALSD.ATGFLGYMILKQIGVCALGSFMLDPTSMAETLQTLGANP.PKKPRPLF........KTLDAMPRPPEYLIHSEWDATEMAQMGFAKVLVNHAIRKIHDDGVMAHLIR.GPYIMFFQPMMEEPGWR...............
O66762_AQUAE/8-332 ...g-VAVAINKAKVNNTPRFQELMYQVGPKVCITTAMHEGFLGFHAFIQVGAHPLGGRFGAAKVINADS...LeaiqregltaikyNPLELWQYTVWEKWEDHEEMHYQQFDRIFELCVGCFTEVVEGPNEPIYVVREANMPPVIDFTDVPKVLGESMMQAMQGkgGIPKVRLLT-QRIAVVGIHKVKEGMEEKFIEGAVETLELLNKySAGMIGWMILEKIGESPYGTFQIKPPEFWEVVASRGAVP.PKTRETIWgey.gkpeFQLEPAGHPKEFIVHMEWSRPESAMFGPALTAVNPKIKKVHDEKVMTTLAHiPPYYKVFMPLMEDLIL-f..............
A0A0Q1B5C6_9ARCH/3-301 ...k-PYVAINEVEMLNDETTMKMFQQVGPKVCQVTARHPGFVGFQNHMQFGIIPLGTRYGGGSMDMTK-...M.............STMNVYQYTMWKNIKDHEDMHRDNFTSIFRLCSACLSQVVYGPWEPLYEIVDANMPVNTEMTDFTVMFGKKFAAGDPS..GVPPISMPYGKRTIALSEHTVKKDMQKEFESNIMEVMKDFEH.APGFLGYMILKEIGVSAVGSFQLKAKGIHETLESNGEV-.PKDQEGAF........KPEEAVPTPPEYRVHMEWSSPEDAMFGIGRVLFAHPARELHD-KVLDTLIR.GPYIRLLNPMMEGTTWR...............
A0A1P8UIF1_9GAMM/5-307 ...n-PIIAINQTRVANRPETYATMMKVGPKVCITTASHPGFLGFEQLIQTGIHPMAGRFGGGAVDMRKT...L.............NPMGMYQYTVWKDVHSHEEMHHDNFKEIYELCGACMDMVVEGPWEPYYEVIKSDLPQIMSMTDVPQILGDSFAKQEQV..--PKVALSA-QRTVLIGDHWIMHGHEDDFEKGAIETLTWMKEnVPGMIGWMIMKQFGVSAIGSFQLDPEGALK--QTLGANP.PPY-NSNYgdk..vhdTPPIPPQTPTQYLVHMEWESPDHAHMGLAHAMVDYELRQIHNKGVLAHLDR.GPYYMIFAPMMEQGIWR...............
A0A656HKX2_THINJ/1-77 ....--------------------MMKVVPKVCITTASHPGFLGFEQLLQIVIHPMAGRFGGGAMDMRNSdppL.............NPMGMYQYTVWKDVHSHEEMHQ--------------------------------------------------------..------------------------------------------.---------------------------------------.--------........---------------------------------------------------.-----------------frrvq..........
A0A094JY80_9DELT/3-305 ...n-PIIAINMSKVVNRPESYETMHKIGPKVCITTATHPGFLGFEQLLQTGIHPMAGRYGGGALDMHET...L.............NPLGMFQYTIWKDVKSHEEMHYEQFNTIYELCGHCLNMVVEGPWEPFYEIIASDLPPVIGMIDVPNKLGESFSQQKPI..--SKVALAS-QRIILIGDHWIMDGHETAFEKGAEETLRWLNAkAPGMIGWMILKQIGVSAVGSFQLGPEGMIKA--TLGANP.PKY-NTNYgdk..pldKPPIPPQKPTQYFVHMEWESPEHAHQGLGKVLINYELRQIHNKGVLAHLAR.GPYYMLFQPMMEDGCWR...............
D0L035_HALNC/5-309 ...n-PIIAINMAKIANKPDSYETMMKVGPKVCITTASHPGFLGFEQLLQTGIHPMAGRYGGGAVDMRET...L.............NPMGMFQYTVWKDVHSHEEMHHDNFKEIFELCSGCLGMVIEGPWEPYFEVVKSDLPQIMSMTDVPQVLGDSFAKQERV..--PKVALSS-QRTVVIGDHWVMDGHEKAFEQGATETLEWMKAnVPGMVGWMIMKQFGVSAIGSFQLDPEGAMKAVSTLGANP.PEY-NTNYgnk..vhdKPPIPGQTPTQYLVHIEWESPEHAHQGLGHVMVDYELRQIHNNGVLAHLDK.GPYYMFFSPMMEQGLWR...............
#=GR D0L035_HALNC/5-309 SS ...---EEEEEEEEE--SHHHHHHHHHTHHHHHHHHTTSTTEEEEEEEEEEEE--TTTTTTT--S--TTT...-.............BSEEEEEEEEESSHHHHHHHHHHTHHHHHHHHHHHGGGEEEEEEEEEEEEEEEE---EE-GGGHHHHHHHHHHTT---..-----EETT-SSEEEEEEEEE-TT-HHHHHHHHHHHHHHHHHHSTTEEEEEEEEEEEEETTTTT---HHHHHHHTSSSSSS-.--S--BTTBSS..--SS-SEE--BSEEEEEEEEESSHHHHHHHHTHHHHSHHHHHHHHHHTGGGEEE.EEEEEEEEEEEEEGGGG...............
#=GC SS_cons ...---EEEEEEEEEE-SHHHHHHHHHTHHHHHHHHTTSTTEEEEEEEEEEEE--TTTTTTT--SS-TTT...-.............CCEEEEEEEEESSHHHHHHHHHHTHHHHHHHHHHHCCCEEEEEEEEEEEEEEEE---EE-CCCHHHHHHHHHHTT-GG..G----EETTSSSEEEEEEEEE-TT-HHHHHHHHHHHHHHHHHHSTTEEEEEEEEEEEEETTTTT---HHHHHHHCCSSTTSS.--S--BTTBSS..--SSGCCC--BSEEEEEEEEESSHHHHHHHHTHHHHSHHHHHHHHHHCHCCEEE.EEEEEEEEEEEEECCHH...............
#=GC seq_cons ...p.PhlAIN.uclhNpPcoachhtpVGPKVChsTApHPGFlGFpshlQhGlhPMGGRYGGuphDMpcp...L.............NPlslhQYThWKch+DHEEMHcppFspIFcLCuuCLshVl-GPWEPlYEIltuDhP.shuMTDhsshlGppFAtupss....P.luhshspRslAhu-HhVh.G+EppFEpuhhcshchh+c.APGhlGaMlLKplGlSAlGSFQLsscGhhpslpThGssP.Pc..pssa........ps.pstsoPspYlVHMEWts.psAhhGlu+VhlshchRplHD.tVLssLl+.GPYlplhsPMMEsshWR...............
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