GenomeNet

Database: Pfam
Entry: SopE_GEF
LinkDB: SopE_GEF
Original site: SopE_GEF 
#=GF ID   SopE_GEF
#=GF AC   PF07487.15
#=GF DE   SopE GEF domain
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_18665 (release 7.8)
#=GF GA   40.90 40.90;
#=GF TC   50.20 49.80;
#=GF NC   24.90 24.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   12093730
#=GF RT   Structural basis for the reversible activation of a Rho protein
#=GF RT   by the bacterial toxin SopE. 
#=GF RA   Buchwald G, Friebel A, Galan JE, Hardt WD, Wittinghofer A,
#=GF RA   Scheffzek K; 
#=GF RL   EMBO J 2002;21:3286-3295.
#=GF DR   INTERPRO; IPR016019;
#=GF DR   SCOP; 1gzs; fa;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This family represents the C-terminal guanine nucleotide
#=GF CC   exchange factor (GEF) domain of SopE. Salmonella typhimurium
#=GF CC   employs a type III secretion system to inject bacterial toxins
#=GF CC   into the host cell cytosol. These toxins transiently activate
#=GF CC   Rho family GTP-binding protein-dependent signaling cascades to
#=GF CC   induce cytoskeletal rearrangements. SopE, can activate Cdc42, an
#=GF CC   essential component of the host cellular signaling cascade, in a
#=GF CC   Dbl-like fashion despite its lack of sequence similarity to
#=GF CC   Dbl-like proteins, the Rho-specific eukaryotic guanine
#=GF CC   nucleotide exchange factors [1].
#=GF SQ   14
#=GS A0A4R1NMY8_9GAMM/123-262  AC A0A4R1NMY8.1
#=GS C4K8Y0_HAMD5/331-475      AC C4K8Y0.1
#=GS A0A2G3K6S2_9BURK/148-294  AC A0A2G3K6S2.1
#=GS A9MNG9_SALAR/103-238      AC A9MNG9.1
#=GS A0A656YHN9_SALNE/27-162   AC A0A656YHN9.1
#=GS A0A447M3A7_SALBN/3-80     AC A0A447M3A7.1
#=GS A0A0N1J5N7_9PSED/89-226   AC A0A0N1J5N7.1
#=GS A0A509D3H2_9ENTR/11-80    AC A0A509D3H2.1
#=GS A0A4V5T6J0_9ENTR/123-263  AC A0A4V5T6J0.1
#=GS A0A2X4T8T3_SALER/103-238  AC A0A2X4T8T3.1
#=GS Q7P1B7_CHRVO/107-240      AC Q7P1B7.1
#=GS A0A4Z0PIE8_SALET/103-225  AC A0A4Z0PIE8.1
#=GS SOPE2_SALTY/103-238       AC Q7CQD4.3
#=GS SOPE2_SALTY/103-238       DR PDB; 1R9K A; 103-238;
#=GS SOPE2_SALTY/103-238       DR PDB; 1R6E A; 103-238;
#=GS BOPE_BURPS/107-243        AC Q63K41.1
#=GS BOPE_BURPS/107-243        DR PDB; 2JOL A; 107-243;
#=GS BOPE_BURPS/107-243        DR PDB; 2JOK A; 107-243;
A0A4R1NMY8_9GAMM/123-262             ................DEKY....KEQVIDAIFSAMYRDVKTSFKI.........HYfhnkpGvlgeNESSLPRE.YLKTMGQAAYDWGVACYE..K..EG....IYFPKGE..GANPLLNAVLSIL..QKNNPIATRDQ---KNIE....RI-NREINVMVDAYCTAHGLKSPVAFESALIDINKNW---ql
C4K8Y0_HAMD5/331-475                 ................EAKYnqttRNQLIDAGLASVYAQKIDDFKK.........KY.....G....ESSETGQK.FLFEIGKVCKENGVKCTQ.nK..NG....TWVVNGA..GAHPVIYPISQNI..FTKFKMHLKLSNNKTKMYdksiSYITNKVYKKTDELCKQENRITTSDLRSLLDDVEKKVLD-g.
A0A2G3K6S2_9BURK/148-294             ...........nenii----....-KQYYNAIYASIYSDVKDRIGK.........SY.....V...gTGMKTPNK.AWEEIGLVAKEIGLDGGEetKieNNvetiIFTPKAA..GANPLITQILTPVsmDKRYGPHMTRPEQQREYR....EYAKNLAIEQIRSFALQDGWPDPSEFEARLTEIEKKWQ--fn
A9MNG9_SALAR/103-238                 ................DPDY....ARQTCEAMLSSVYSNNKDQCCK.........LL.....V....SKGISITP.FLKEIGEAAQNAGLPGEI..K..NG....IFTPGGA..GTNPFVVPLIASA..SVEYPHMFINYSQQVSFK....AYAEKIIMKEVTPLFNEGTMPTPQQFQLTVENIANKYLQN..
A0A656YHN9_SALNE/27-162              ................DPAY....ASQTREAILSAVYSKNKDQCCN.........LL.....I....SKGINIAP.FLQEIGEAAENAGLPGTT..K..ND....VFTPSGA..GANPFITPLISSA..NSKYPRMFINQHQQASFK....IYAEKIIMTEVAPLFNECAMPTPQQFQLILENIANKYIQ-y.
A0A447M3A7_SALBN/3-80                .............clp----....----------------------.........--.....-....--------.------------------..-..--....---PGGA..GANPFITPLVSSA..SIKYPYTFINHNQQTSFK....AYAEKLIMEEVTPLFKEQNLPTPQQFHLTLENIASKYIQN..
A0A0N1J5N7_9PSED/89-226              dpknreelvagcftli----....----------------HDNCEKl......vdKQ.....K....MPSDQALS.FKQQLGRLAWKVGLPGEA.nK..QG....VFVPRGAgsGANPLLNPLKDLI..LREHAHIFKHPVLREKIF....AMAEKKIIAFVSDHMNPEESKRLDCFQHERALLEKQWRN-d.
A0A509D3H2_9ENTR/11-80               ............ktri----....RSQTREAILSAVYSKNKDQCCK.........LL.....I....SKGINIAP.FLKEIGEAAQNAGLPGAT..K..ND....VFTPSGA..GANPL--------..------------------....----------------------------------------..
A0A4V5T6J0_9ENTR/123-263             ................DAIY....REQILDAMFSAVYQDVKLSFEKfcfyngqnrQD.....S....NGTDIPDG.YLQAIGQAAHDWGVACNL..K..ND....AYIPKGA..GANPLLTSVISIV..QKTHPAAMNTPENIEKVK....NDI----NAMVEGYCVDNGIKGPLQFKAVLLEITEQWQ--kt
A0A2X4T8T3_SALER/103-238             ................DPDY....ARQTCEAMLSSVYSNNKDQCCK.........LL.....V....SKGISITP.FLKEIGEAAQNAGLPGEI..K..NG....IFTPGGA..GTNPFVVPLIASA..SVEYPHMFINYSQQVSFK....AYAEKIIMKEVTPLFNEGTMPTPQQFQLTVENIANKYLQN..
Q7P1B7_CHRVO/107-240                 ................DPVY....RRQALESTYATIYSEAKQAFYR.........--.....A....NGGKMPEG.YLRELGEAARAAGLPGEN..K..HG....VFIPSGD..GASPFVNYLLIPV..QKEFGHRLRNESQQRLFR....DFARQLSMELVAPHAAERGWEPPAAFAARLEAVGRPWLAQ..
A0A4Z0PIE8_SALET/103-225             ................DPAY....ARQTCEAILAAVYSNNKDQCCK.........LL.....I....SKGISITP.FLKEIGEAAQNAGLPGEM..K..NG....VFTPGGA..GANPFVVPLIAAA..SIKYPHMFINHNQQVSFK....AHAEKIVMKEVTPLFNKGTMPTPQQFQ-------------..
SOPE2_SALTY/103-238                  ................DPAY....ARQTCEAILSAVYSNNKDQCCK.........LL.....I....SKGVSITP.FLKEIGEAAQNAGLPGEI..K..NG....VFTPGGA..GANPFVVPLIASA..SIKYPHMFINHNQQVSFK....AYAEKIVMKEVTPLFNKGTMPTPQQFQLTIENIANKYLQN..
#=GR SOPE2_SALTY/103-238       SS    ................-HHH....HHHHHHHHHHHHHHHHHHHHHH.........HH.....H....HHT--HHH.HHHHHHHHHHHTT--EEE..-..SS....-EEETT-..SS-TTHHHHHHHH..HHH-HHHHSSCCHHHHHH....HHHHHHHHHHHGGGGTSSS---HHHHHHHHHHHHHHHHHT..
BOPE_BURPS/107-243                   ................DAEF....GRQVYEATLCAIFSEAKDRFCM.........DP.....A....TRAGNVRPaFIEALGDAARATGLPGAD..K..QG....VFTPSGA..GTNPLYTEIRLRA..DTLMGAELAARPEYRELQ....PYARQQAIDLVANALPAERSNTLVEFRQTVQTLEATYRR-a.
#=GR BOPE_BURPS/107-243        SS    ................TTTH....HHHHHHHHHHHHHHHHHHHHHH.........SG.....G....GSSSSSHHHHHHHHHHHHHHCT-S-EE..E..TT....EEE--S-..-S-SCHHHHHHHH..HHHHTTHHHHSCHHCC-S....HHHHHHHHHHHHHTSTCHHHHHHHHHHHHHHHHHHHHHH-H.
#=GC SS_cons                         ................TCCH....HHHHHHHHHHHHHHHHHHHHHH.........CH.....H....HCTSSCHHHHHHHHHHHHHHCT-SEEE..E..TT....EEEETT-..SS-TCHHHHHHHH..HHHHCCHHCCCCHHCCHC....HHHHHHHHHHHHHCCTCCCHHHHHHHHHHHHHHHHHHHHTH.
#=GC seq_cons                        ................Ds.Y....tcQsh-AhhuulYSpsKDphpK.........hh.....h....spuhshps.FLcEIGcAApssGLPGp...K..NG....lFsPuGA..GANPhlssllsss..phcasthhhs.spptph+....saAcphlhc.Vsshhsppsh.oPppFphtlpsltppaht...
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