#=GF ID   Ste5_C
#=GF AC   PF12194.14
#=GF DE   Protein kinase Fus3-binding
#=GF PI   ste5minscaffold;
#=GF AU   Mistry J;0000-0003-2479-5322
#=GF AU   Gavin OL;
#=GF SE   pdb_3fze
#=GF GA   25.00 25.00;
#=GF TC   25.00 25.00;
#=GF NC   24.90 24.20;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 81514348 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0128
#=GF RN   [1]
#=GF RM   8943027
#=GF RT   Dimerization of Ste5, a mitogen-activated protein kinase cascade
#=GF RT   scaffold protein, is required for signal transduction.
#=GF RA   Yablonski D, Marbach I, Levitzki A;
#=GF RL   Proc Natl Acad Sci U S A. 1996;93:13864-13869.
#=GF DR   INTERPRO; IPR021106;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain family is found in eukaryotes, and is approximately
#=GF CC   190 amino acids in length. This domain is the penultimate C
#=GF CC   terminal domain from the protein ste5 which co-catalyses the
#=GF CC   phosphorylation of fus3 by ste7. It is involved in the MAPK
#=GF CC   pathways. This domain is the minimal scaffold domain of ste5. It
#=GF CC   binds to the mitogen activated protein kinase fus3 before it is
#=GF CC   phosphorylated.
#=GF SQ   30
#=GS A0A1E5RVE3_9ASCO/499-649   AC A0A1E5RVE3.1
#=GS G0V9Z2_NAUCC/615-804       AC G0V9Z2.1
#=GS A7TJH8_VANPO/599-787       AC A7TJH8.1
#=GS A0A1G4MK69_LACFM/558-746   AC A0A1G4MK69.1
#=GS A0A1X7R6A5_9SACH/583-771   AC A0A1X7R6A5.1
#=GS G8JS69_ERECY/510-700       AC G8JS69.1
#=GS STE5_YEAST/594-785         AC P32917.2
#=GS STE5_YEAST/594-785         DR PDB; 4F2H A; 594-774;
#=GS STE5_YEAST/594-785         DR PDB; 3FZE A; 594-780;
#=GS I2H533_TETBL/650-838       AC I2H533.1
#=GS Q6FL43_CANGA/371-561       AC Q6FL43.1
#=GS A0A0C7N9Q7_9SACH/565-756   AC A0A0C7N9Q7.1
#=GS G0WGW1_NAUDC/642-832       AC G0WGW1.1
#=GS Q6CKB4_KLULA/499-686       AC Q6CKB4.1
#=GS J7S1Y2_KAZNA/648-844       AC J7S1Y2.1
#=GS G8BPS0_TETPH/605-793       AC G8BPS0.1
#=GS H2AR28_KAZAF/586-775       AC H2AR28.1
#=GS G8ZX41_TORDE/421-611       AC G8ZX41.1
#=GS A0A1G4JIU1_9SACH/568-756   AC A0A1G4JIU1.1
#=GS Q74ZU4_EREGS/514-703       AC Q74ZU4.1
#=GS A0A4C2E720_9SACH/566-755   AC A0A4C2E720.1
#=GS A0A7H9B767_ZYGMR/606-793   AC A0A7H9B767.1
#=GS C5DN46_LACTC/557-744       AC C5DN46.1
#=GS C5DSP8_ZYGRC/566-755       AC C5DSP8.1
#=GS A0A7H9I0P1_9SACH/582-770   AC A0A7H9I0P1.1
#=GS A0A376B763_9ASCO/731-927   AC A0A376B763.1
#=GS W0T953_KLUMD/513-699       AC W0T953.1
#=GS A0A1D2VLF9_9ASCO/861-1051  AC A0A1D2VLF9.1
#=GS A0A1E5R6X5_HANUV/780-972   AC A0A1E5R6X5.1
#=GS A0A1G4KIP3_9SACH/560-742   AC A0A1G4KIP3.1
#=GS J8Q9F9_SACAR/603-793       AC J8Q9F9.1
#=GS A0A1B7TIF5_9ASCO/490-681   AC A0A1B7TIF5.1
A0A1E5RVE3_9ASCO/499-649              pws-----------..-.-------------.-----........-------------....--..----....VKLC..CIDETGKVLSSGQISDVLKQLG...STP...GLQFSQIR..gKMLTSDYWDQT.LiqxY..YQDS....DTPIEVCIISNCGVXNSTGILsnpstntktnIMMWNNFFTLTKET--..LCKIHIGY..LNEDIGD---ELIEINNWTEIMELLCVYYGFEFGQDFE---dl.
G0V9Z2_NAUCC/615-804                  ...TTISSILSLKR..E.RPDDVVIVLQIDF.KKIKN.......eDDYTTIYNTLKAL....TF..KFPR....LKAC..IVDAERNTLAIEPVADFIKNKD...ELR...NLKDREIG...KTFNIPWLKET.L...Y..PSGI....RQNIGIVVISNSSMENDKSVL..........LMDFQPFTCAGRRRPN..ELKLKVGY..LNVDYSEKVNELVEIESWCSLLETLCYSLTLNFDDDGDTYD...
A7TJH8_VANPO/599-787                  ...TSVSSILSLKR..E.RPEGIVIILQLDF.RKLKD........DSYIIIYNSLQAL....VT..KYPN....LIYC..TVDADGFVVQYGQASKDILNLQ...SIY...KMNKPNAG...IKFSPTWLKNT.I...Y..PLGI....TSSLGIAILSNGSMEEARSCL..........LMDYKIFASPGRRHAN..ELKIKVGY..LNSDYSDKITELVEIGTWAFMLEALCYSFSLSFEDDDDDED...
A0A1G4MK69_LACFM/558-746              ..a-TITSILSLKR..E.RPESLIVVLQLSF.RYLND........SDTLIIRNSLKAL....TF..KFPG....ARMC..VVDALGRIVTYGAINDNLSEIG...KAQ...EDTNCSSR...AKFTPELLKS-.W...Q..NTDS....DERLAIAIFSNSPMEEGKSCL..........FMDYKVFANENRREAN..ELKVRVGC..LNFDYADKIHQLVEIASWSNLLEIACYSFNFSFDEEDSED-sd.
A0A1X7R6A5_9SACH/583-771              ...TSISSIISMRR..K.KPDNLIVIIQIDK.RYVIS.......eDIYSTIYNNLKAL....EI..LFPS....LYIC..LVDSKMSLVRQGPASEIIKTPE...DL-...--KISTPI...CSFNSKLLRET.V...L..NVTIs..sSRTVGIALISNTMMNKESCIL..........FQQIALLRKMGELRAN..ILKIKVGY..LNMNYTDQIDELVEIDNWTDMLELLCYTFAIDYDSEDDNSD...
G8JS69_ERECY/510-700                  ...TRISSILSLKR..K.IPNDLFIVFQIDP.IKLLD........GDVNTLVNICKAL....SW..KLET....AKLC..LVDKDGYLVTSCSLKLAIPKLK...GLN...SLLAEADR..sIKFSPADIYQQ.I...Y..GAWQ....RENIGVTIISNSSMETGRSAL..........LMDYSAFCNVGKRRPN..ELKIKVGY..LNADYSDKVYELVETDKWNDVFEVICYSFNMAFGQDALTD-ed.
STE5_YEAST/594-785                    ...TTISSILSLKR..E.KPDNLAIILQIDF.TKLKE.......eDSLIVVYNSLKAL....TI..KFAR....LQFC..FVDRNNYVLDYGSVLHKIDSLD...SIS...NLKSKSSS...TQFSPIWLKNT.L...Y..PENI....HEHLGIVAVSNSNMEAKKSIL..........FQDYRCFTSFGRRRPN..ELKIKVGY..LNVDYSDKIDELVEASSWTFVLETLCYSFGLSFDEHDDDD-eed
#=GR STE5_YEAST/594-785         SS    ...HHHHHHHHHHH..T.--SEEEEEEEE-C.CC-SS.......TCCHHHHHHHHHHH....CC..C-TT....-EEE..EEETTSBEEEEEEHHHH--SCH...HHH...HGGG----...-B--HHHHHHH.H...-..TT--....-S-EEEEEEE-S---TTT-CC..........CS-GGGG--TT-SS--..EEEEEES-..-SS--TTTSSSEEEES-HHHHHHHHHHCTT--SS----XX-XXX
I2H533_TETBL/650-838                  ...TNVSLMVSLKR..D.CPEKMVLVLQLKD.NTIPQ........ETSRLIFNTIFAV....RS..RLSK....MQIT..IVNEDAMVIYFGEFLDKLDEFN...KL-...LVKDSSNN...IKFSPSWLKKQ.L...N.lSAGS....TDNTAIAIVSEAAMKKGSSCL..........LMDYSPFAAKGKRIAN..EVKIKVGY..LNVDYTDQITELVEVGGWKFVLEMLCYSFSLNFEDDDDE--sy.
Q6FL43_CANGA/371-561                  ...TITSSVLSIKK..E.KPSDILLLIQIDE.QKITDq.....kdQIKQVIKNTLMAL....KL..KYPE....YFLV..ILSATGEVLLMDSI-DRLNLDN...QLL...SGEEPKNP...FRLEISSIRTH.V...Y..GTSI....LENLAIVAVSNSAMVETTSIL..........FKNFSPLISKGRLRPN..EIRIKVGY..SNNDYSDVVSELVEIESWDYLLEALCHTFSLDYDDDYTSY-e..
A0A0C7N9Q7_9SACH/565-756              ...TTITSLLSLQR..D.RPKNLAIVLQVDL.THLKD........TDFLALVNSLRAL....IM..NMKE....TQMC..LVDPSGRMINQGVAEEQIAQLK...ILKiasRTSDADNR...PKFSPTQFKVA.C...C..S-KM....TDDVGIVVFSNTSVEAGKSCL..........FMDYKAFSSSNRSRPH..ELKVHVGF..LNVDYTDQVSELVEVSSFQNILETVSYGFNLTFGEDNDDF-dd.
G0WGW1_NAUDC/642-832                  ...TTISSILSLKR..E.RPDDIIIVLQLDL.NKLKL.......gNNSTTLYNSLTAL....NM..KFPN....FKIC..IVDSNSNVLAYGDVMKAVINAA...DIL...KCEHKNAG..nQNFTPEWLKNV.F...Y..PNCM....DQNIGIIVISNTVMELDKSCL..........FMDYKPFTCLGRRRPN..ELKIKVGY..LNVDYSDEINELVEIESWNYLLETLCYSMSLNFDDEDDEND...
Q6CKB4_KLULA/499-686                  ...TSISSILSIKR..A.TPNELNLVLQLDK.RKTNE........DNIVSIKNVILAL....TW..KFST....FNCC..IVDVEGMVINCGTANDVL---N...SLA...GPIKSNGN...QPFSPDLLHQL.W...YrqKQKI....CKNVGVVVLSNSSMENGKSCL..........FSDYRIFADAGKRHPN..ELKIKVGF..LNVDYSDNIKELVEIQDWNELLEAVAYSFNLSFDDDLDSSD...
J7S1Y2_KAZNA/648-844                  ...TTASSILSLKR..E.RADELILVIQLDF.DKLKEksggiggvSDYTTIFNTFKAL....SL..KYAR....LPFC..VLNSAGYILKIGQVKQEFSNLK...CVE...EWIDLKPT...SKFDPKELKNI.L...H..PEGI....QKHIQLVIVSNSSMEEGMSSL..........LMDYRSFSAPKRRHAD..EIKIKVGY..LNVDYSDKIDELLEINSWEFMLEALCYNFSLNFDEDDDGVD...
G8BPS0_TETPH/605-793                  ...TSFSSIISMKM..K.KPENLLLVVQIDF.RKLNQ........GEELVIKNTIRAL....TL..NYSD....LHMC..FVDNHSKVIKIVPTKDIVNGTD...YFK...DLSQIKGS...TSFSPSWLLSE.L...Y..PDGV....KTSLGVSVISNTKMDETESIL..........FMDFDKFNGLGRKKVH..QLKVHVGF..LNIDYSEEIQELLEINNWNLLLESLCFTFDIVYGQDEDTVD...
H2AR28_KAZAF/586-775                  ...TTISSILSLKR..E.RPDDLVIIFQIDF.FKVKN.......nDDILNFYNILKAL....LL..KFPE....CKFC..AVNTAGFIIDYGLITEKVEGPD...YFQ...VINKVDGT...IKFEPTWLKSL.L...F..PQEI....RHNVAIVIVSNSSMEADKSCL..........LMDYNPFASNGRRRPN..ELKVKVGY..LNIDYSDKINELIEIDSWSVLLEALCYSFTLNFDEDEGS--ey.
G8ZX41_TORDE/421-611                  ...TTVSSILSLKR..D.RPDELIVVLQWNL.KETNN........GLALDIYNNVRAL....SL..TYRD....LKVC..IVNEEGRVANHALAKDFFTTSD...RVL...GLKDNNGT...VRFDPKWLKNT.F...Y..PGNI....TANIGIAVISDISLESDKSCL..........LMDYKPFARVGRRRPN..ELKVKIGYllLNVDYSKRIEELVEVGSWNQILEALSYSFSLAFGDDDEDDD...
A0A1G4JIU1_9SACH/568-756              ...TTITSLLSLKR..D.RPSNLAIVLQLEI.SRLKH........DELTTAVNSMRAL....VM..KMQE....TNIC..IVDQNARIVSQGPAQEQIAILA...NLS...SEMPNSPY...PQFTPELFKE-.I...S..CINM....RATVGIAVFSNTSVEEGKSCL..........FMDFGCFANPKRTRPN..ELKAHIGY..LNFDYMDLVEELVEVSSFNDILETLCYCFNITFDEDDGD--cdd
Q74ZU4_EREGS/514-703                  ..a-SINSILSLKR..R.HPDELCLFFQIDT.AKVQA........VDYKILANTCKAI....LW..KFNT....AKVA..LADSNGGIVTMSLLKDFIPIFS...SID...HILRRHET..rRKLSPNLVYRH.F...Y..GKER....LKNVGVCIISNSAMQYGKSLL..........LMDYSAFCNIGKKRPN..ELKVKVGY..LNTDYSDQVFELVETGGWGDVLEVVCYSFNMAFGQDDYSDD...
A0A4C2E720_9SACH/566-755              ...TNISSILSLKR..G.KPDDLVVVLQLDF.DKIDV.......kIDSLVIFNSLKAL....VL..KFPD....LKIC..IVDSRGIVKTHGRVRELITTVK...DLE...NMQKPSGS...NRFEPIWLKNL.L...Y..PNTP....LTNLGIAVISNTPMDTQKSCL..........LKDYSCFTNEGRRRPK..ELKIKVGY..LNSDYSDKISELLELESWNDFLEALSYSFSLAFGDDDDDND...
A0A7H9B767_ZYGMR/606-793              ...TSISRILSLKR..E.TPDDLVIVLQLDY.EKLKK.......dNGFKIIDNSLRAL....NS..KFLS....LKLC..LVDSDGFLIDSFLLGS--HHFT...SVM...EMASCNSD...RKFEPQWLKNK.Y...Y..PGGL....TQNVGIAVISNSSMQNGKSSL..........LLDYDSFTCGGRRRPN..ELKVKIGY..LNADYSDRVNDLVEVESWNDLLEAVSYSFSIYFGDDDDDN-i..
C5DN46_LACTC/557-744                  ...TTITSLLSLKR..G.RPTLLALVLQLDP.SRLKD........AELIGLVNSLMAL....TF..KIRD....ARLC..LVDLEGGIVSQGLVREQLSVVK...DLK...STVKDHNR...ARFNPADFKNE.F...I..WENV....DK-IGIAVISNTLVESGKSCL..........FMDYNSFAGINRTRPH..ELKIHIGF..LNVDYTDCISELVEVASAHDLLETLCYGFNLSFEEEDDNND...
C5DSP8_ZYGRC/566-755                  ...TNISSILSLKR..E.RPDELVVVLQLDF.EKIRT.......kNNSLVIFNSLKAL....VL..KFPD....MKIC..IVDSGGFVRTLGRTKDVISTVE...DLE...DAQKLSEG...NRFEPIWLKNS.L...Y..PDTT....LKGLGIAIVSNTPMDTQKSCL..........LKDYSCFTNEGRRRPR..ELKIKVGY..LNLDYSDKVGELVELESWNNFLEALSYSFGLAFGDDDDDD-v..
A0A7H9I0P1_9SACH/582-770              ...TSISSILSLKR..E.KPDDLVVVLQFNF.EDPNF.......fNSLPIIHNNIKAL....NI..KFRD....LKIC..VVNEKGYVIQHGHVDKITFDPD...SIT...SLQKTSGT...NKFNPEWLRNT.F...Y..PNGV....LGNVGVAVVSASSMEEGKSCL..........LMNYKPFTCPGRRRPN..ELKVKVGY..LNVDYSDSIEELVEVAAWANVLEALSYSFSLVFGDDEDE--e..
A0A376B763_9ASCO/731-927              ...TIITFYLTLKK..R.EPTELIIVLQLDSeKKITQ........IQNNNLINAIKAL....NTypKLKK....LHLC..CISEDLKILCFGSTTHVLSQMS...SGL...NFKQF-RG...ATFTPEDLFYK.I...Y..PHGAsndfLNDVGLVVISNSSMNESKSCL..........FMNYNIFGSNPTQFENfsGIKIHVGF..LNVDYSNKISELLEIDTWNDLLEVISFTFNIKFGEDSEE--vv.
W0T953_KLUMD/513-699                  ...TSISSILSIKR..S.TPRELNVILQVDR.RKLKS........ENLITIKNVLSAL....TW..KYHD....FNCC..IVGVDGLIVKIGGAREILDSWA...EI-...---SDAGT...QPFSPALLYKT.W...YkeRGKV....CNNAGVLVISNASMETGKTCL..........FHDYRMFANVGKRHVN..ELKIKVGF..LNVDYTSKIKELVEIQDWNELLEAVSYSFNINFDDDDDDDD...
A0A1D2VLF9_9ASCO/861-1051             .fk--INSITNVNKatK.KPSNLIFIFNTEI.-DLSK........DLQISLLNILRAL....SL..KIKN....IYIIetFNDFNSYYCDGPLLVNNNINNK...FLD...NLGIINHSi.lKKFDINTLYNQeI...V..SNEA....SSDLNILYLSTQQIHSLP-NF..........NKDHQELVLELPSIKN..ESEMSSIK..RNTDLAKRV---VFVHSWDSLMEVICSSFSISFDDDDSDED...
A0A1E5R6X5_HANUV/780-972              .ne--VSTTLPIKS.yS.EVEDLILILQLDSeKKIKI........SENFNLVNSIKSLndyfTK..KXKT....LKFV..ILDQKLKVLCVGSSKDVLNQLNgrmKFE...QIRGKKFT...ESFWSNSVLQK.Y...F..XSTE....DSKLNIVVMSNTEMNVEQNCL..........FKDFYASS-----FED..VLKVHVGF..LNIDYSEEINDLVEINTWFDLMEILCFSLNLEFGQDDLDND...
A0A1G4KIP3_9SACH/560-742              ..g-TISSTLSLKK..S.KPSDLLVIFQLDL.RTVSQ........HDMRTLKNSLQAL....TL..QDEN....CKVC..LVDIAGDVLSFGLIKEQLPNFG...QHK...K-----SQ...TPSNIQELVKS.T...-..AESV....TSTFGIAVFSSTPMDKSKSYL..........FKDFKAFSQLERKKVK..ELKVHIGY..LNVDHSDEISELAEISSWENMIEMMCFAFNMTFDDDDDDDD...
J8Q9F9_SACAR/603-793                  ...TTISSILSLKR..E.RPDNLVVILQVDF.RKVEK.......hGNLIVIYNSLKAL....MI..KFSL....LQFC..FVDRNNNVLDYGLVSRKIDTVD...DIS...KLISKSLS...TQFSSRWLKDI.L...Y..PGKI....HEHLGIIAVSDSNMEAGKSVL..........FQDYKCFTSLGRRRPN..ELKVKVGY..LNVDYSDRIGELVEVGSWNFVLETLCYSFSLSFDEDDEEE-ed.
A0A1B7TIF5_9ASCO/490-681              ..l-QISNLMPIKN..NlKPKDLIVVLQIDS.QKLIK.......kSENHNLINSIKAL....KN..YYELkkgiFRIV..VLDETLKILSIGTANDILCQLN...GLI...SFTQIRGKklnGNLWSSLVMQK.-...Y..YSET....ENDIGIVVLSNSEMKENTNCL..........FKDF--FGS----QEN..LLKVHIGY..LNVDYSDFITDLVEINTWMDLMEIICYSFDIEFGQDDCDD-ee.
#=GC SS_cons                          ...HHHHHHHHHHH..T.--SEEEEEEEE-C.CC-SS.......TCCHHHHHHHHHHH....CC..C-TT....-EEE..EEETTSBEEEEEEHHHH--SCH...HHH...HGGG----...-B--HHHHHHH.H...-..TT--....-S-EEEEEEE-S---TTT-CC..........CS-GGGG--TT-SS--..EEEEEES-..-SS--TTTSSSEEEES-HHHHHHHHHHCTT--SS----XX-XXX
#=GC seq_cons                         ...ToISSILSLKR..c.+P--LllVLQlDh.pKlpp........sshhslhNol+AL....sh..Kats....h+lC..lVDpsGhllshG.sp-hlsphs...slp...phpppsss...ppFsPphL+pp.h...Y..sssh....ppslGIsllSNosM-psKSsL..........hhDYpsFss.GR++sN..ELKlKVGY..LNlDYSDcIsELVElsoWsslLEsLCYSFslsFs-DD--s....
//