#=GF ID   Trp_leader1
#=GF AC   PF08055.14
#=GF DE   Tryptophan leader peptide
#=GF AU   Lee SC;0000-0002-0504-0859
#=GF SE   Short protein clustering
#=GF GA   25.00 25.00;
#=GF TC   25.00 25.10;
#=GF NC   20.20 24.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   15262409
#=GF RT   The different roles of tryptophan transfer RNA in regulating trp
#=GF RT   operon expression in E. coli versus B. subtilis. 
#=GF RA   Yanofsky C; 
#=GF RL   Trends Genet 2004;20:367-374.
#=GF DR   INTERPRO; IPR012638;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of the tryptophan (trp) leader peptides.
#=GF CC   Tryptophan accumulation is the principal event resulting in
#=GF CC   downregulation of transcription of the structural genes of the
#=GF CC   trp operon. The leader peptide of the trp operon forms mutually
#=GF CC   exclusive secondary structures that would either result in the
#=GF CC   termination of transcription of the trp operon when tryptophan
#=GF CC   is in plentiful supply or vice versa [1].
#=GF SQ   57
#=GS A0A6B3GTN4_9ACTN/25-38    AC A0A6B3GTN4.1
#=GS A0A5Q4SFU3_9ACTN/1-18     AC A0A5Q4SFU3.1
#=GS A0A6B2XDX0_9ACTN/1-18     AC A0A6B2XDX0.1
#=GS A0A4Q9HW98_STRKA/291-310  AC A0A4Q9HW98.1
#=GS A0A2U3A8J6_9ACTN/1-18     AC A0A2U3A8J6.1
#=GS A0A5J6FE92_9ACTN/17-34    AC A0A5J6FE92.1
#=GS A0A6G4UC64_9ACTN/1-18     AC A0A6G4UC64.1
#=GS A0A2T7SRW8_9ACTN/43-60    AC A0A2T7SRW8.1
#=GS A0A2G5IVI9_9ACTN/1-18     AC A0A2G5IVI9.1
#=GS A0A6B2S0S6_9ACTN/19-36    AC A0A6B2S0S6.1
#=GS A0A2G9DVR4_9ACTN/39-56    AC A0A2G9DVR4.1
#=GS A0A652L0G9_9ACTN/30-47    AC A0A652L0G9.1
#=GS A0A5J6HV48_STRAD/1-19     AC A0A5J6HV48.1
#=GS A0A370B2W7_9ACTN/1-18     AC A0A370B2W7.1
#=GS A0A5N8WBN5_9ACTN/1-20     AC A0A5N8WBN5.1
#=GS A0A2U9NZS3_STRAS/9-26     AC A0A2U9NZS3.1
#=GS A0A372LXZ5_9ACTN/17-34    AC A0A372LXZ5.1
#=GS A0A4R9F302_9ACTN/1-19     AC A0A4R9F302.1
#=GS A0A2M9J9R5_9ACTN/15-32    AC A0A2M9J9R5.1
#=GS A0A5N8VFH2_9ACTN/1-18     AC A0A5N8VFH2.1
#=GS A0A553ZJ80_9ACTN/77-94    AC A0A553ZJ80.1
#=GS A0A4V2XPB8_9ACTN/1-18     AC A0A4V2XPB8.1
#=GS A0A1V6MRX4_9ACTN/1-18     AC A0A1V6MRX4.1
#=GS A0A2S1Z8I6_9ACTN/5-22     AC A0A2S1Z8I6.1
#=GS A0A4R9E914_9ACTN/1-18     AC A0A4R9E914.1
#=GS A0A5Q0LIF2_9ACTN/35-52    AC A0A5Q0LIF2.1
#=GS A0A4Q6IT53_9ACTN/1-18     AC A0A4Q6IT53.1
#=GS A0A6G2UF11_9ACTN/7-22     AC A0A6G2UF11.1
#=GS A0A429UM11_9ACTN/8-22     AC A0A429UM11.1
#=GS A0A504BL39_9RHIZ/28-45    AC A0A504BL39.1
#=GS A0A3G2JQ48_9ACTN/1-18     AC A0A3G2JQ48.1
#=GS A0A6I5FDY0_9ACTN/19-36    AC A0A6I5FDY0.1
#=GS A0A345XZY6_9ACTN/1-18     AC A0A345XZY6.1
#=GS A0A6I4MXR7_9ACTN/1-18     AC A0A6I4MXR7.1
#=GS A0A1V4A7V9_9ACTN/1-18     AC A0A1V4A7V9.1
#=GS A0A4S2UNP2_9ACTN/1-18     AC A0A4S2UNP2.1
#=GS A0A4Z0HAC9_9ACTN/21-38    AC A0A4Z0HAC9.1
#=GS A0A4P6TRZ8_STRSO/18-35    AC A0A4P6TRZ8.1
#=GS A0A6B3G091_9ACTN/25-42    AC A0A6B3G091.1
#=GS A0A4R4SIP9_9ACTN/1-18     AC A0A4R4SIP9.1
#=GS A0A6H9UYC5_9ACTN/1-18     AC A0A6H9UYC5.1
#=GS L1KMD2_9ACTN/1-20         AC L1KMD2.1
#=GS A0A6B3HXW4_9ACTN/25-42    AC A0A6B3HXW4.1
#=GS A0A505DKE1_9ACTN/63-80    AC A0A505DKE1.1
#=GS A0A514K1C2_9ACTN/1-18     AC A0A514K1C2.1
#=GS A0A498E316_9ACTN/1-18     AC A0A498E316.1
#=GS A0A6H0CK72_9ACTN/17-34    AC A0A6H0CK72.1
#=GS A0A3S8X6N1_9ACTN/1-18     AC A0A3S8X6N1.1
#=GS A0A5N8XW70_9ACTN/1-20     AC A0A5N8XW70.1
#=GS A0A550HYJ6_9ACTN/24-37    AC A0A550HYJ6.1
#=GS A0A2M9K0D6_9ACTN/11-28    AC A0A2M9K0D6.1
#=GS A0A3A9Z578_9ACTN/1-18     AC A0A3A9Z578.1
#=GS A0A6N2I835_9ACTN/1-18     AC A0A6N2I835.1
#=GS A0A7H8IZ21_9ACTN/1-18     AC A0A7H8IZ21.1
#=GS A0A2R4TDZ7_9ACTN/1-18     AC A0A2R4TDZ7.1
#=GS A0A6G4VFT4_9ACTN/1-20     AC A0A6G4VFT4.1
#=GS A0A371PWC6_9ACTN/19-34    AC A0A371PWC6.1
A0A6B3GTN4_9ACTN/25-38               .......i----.SI..Q..NWWWTAHPAA-.
A0A5Q4SFU3_9ACTN/1-18                ........MFAQ.TT..Q..NWWWTAHPAA-r
A0A6B2XDX0_9ACTN/1-18                ........MFAH.ST..Q..NWWWTAHPAAH.
A0A4Q9HW98_STRKA/291-310             myaqpvms----.--..M..NWWWTAHPAAH.
A0A2U3A8J6_9ACTN/1-18                ........MFAH.ST..Q..NWWWTAHPAAH.
A0A5J6FE92_9ACTN/17-34               ........MFAQ.TT..Q..NWWWTAHPAA-r
A0A6G4UC64_9ACTN/1-18                ........MHAP.TC..R..NWWWPAHPAA-t
A0A2T7SRW8_9ACTN/43-60               ........MFAH.SN..Q..TWWWTARSAAH.
A0A2G5IVI9_9ACTN/1-18                ........MFAH.ST..Q..NWWWPAHPAAH.
A0A6B2S0S6_9ACTN/19-36               ........MFAT.TT..R..NWWWTAHPAAH.
A0A2G9DVR4_9ACTN/39-56               ........MFAH.SN..Q..NWWWTAHPAAH.
A0A652L0G9_9ACTN/30-47               ........MFAQ.TT..R..NWWWTAHPAAH.
A0A5J6HV48_STRAD/1-19                ...mhaqt----.TT..R..NWWWPAHPAAH.
A0A370B2W7_9ACTN/1-18                ........MFAL.SY..Q..TWWWTARPAAH.
A0A5N8WBN5_9ACTN/1-20                ........MFAH.ST..QnqNWWWTAHPAAH.
A0A2U9NZS3_STRAS/9-26                ........MFAL.ST..Q..NWWWTAHPAAH.
A0A372LXZ5_9ACTN/17-34               ........MFAH.TT..R..DWWWTARPAAH.
A0A4R9F302_9ACTN/1-19                ........MFAHaSI..Q..NWWWTALPAAH.
A0A2M9J9R5_9ACTN/15-32               ........MFAH.SI..Q..NWWWTAHPAA-r
A0A5N8VFH2_9ACTN/1-18                ........MYAL.ST..Q..NWWWTAHPAAH.
A0A553ZJ80_9ACTN/77-94               ........MYAP.HV..T..NWWWTAHPAA-r
A0A4V2XPB8_9ACTN/1-18                ........MFAQ.QT..N..SWWWTASPAAH.
A0A1V6MRX4_9ACTN/1-18                ........MFAP.SI..Q..NWWWTAHPAAH.
A0A2S1Z8I6_9ACTN/5-22                ........MFAQ.TT..Q..NRWWTAHPAAH.
A0A4R9E914_9ACTN/1-18                ........MFAH.SN..Q..NWWWTARPAAH.
A0A5Q0LIF2_9ACTN/35-52               ........MFAH.SH..Q..TWWWTAHPAAH.
A0A4Q6IT53_9ACTN/1-18                ........MFAH.SH..Q..TWWWTASPAAH.
A0A6G2UF11_9ACTN/7-22                ......qi----.SI..Q..NWWWTAHPAA-r
A0A429UM11_9ACTN/8-22                .......l----.SI..Q..NWWWTAHPAA-r
A0A504BL39_9RHIZ/28-45               ........MFAQ.TT..Q..NWWWTAHPAA-r
A0A3G2JQ48_9ACTN/1-18                ........MFAP.SI..Q..NWWWTASPAA-r
A0A6I5FDY0_9ACTN/19-36               ........MFAH.ST..R..DWWWTAHPAAH.
A0A345XZY6_9ACTN/1-18                ........MFAQ.TT..R..NWWWPAHPAAH.
A0A6I4MXR7_9ACTN/1-18                ........MHAQ.TI..R..NWWWPAHPAAH.
A0A1V4A7V9_9ACTN/1-18                ........MFAH.ST..R..NWWWTAPPAA-r
A0A4S2UNP2_9ACTN/1-18                ........MFAH.ST..R..NWWWTAHPAAH.
A0A4Z0HAC9_9ACTN/21-38               ........MFAR.LT..M..DWWWTAHPAA-c
A0A4P6TRZ8_STRSO/18-35               ........MFAQ.QI..Q..NWWWTALPAAH.
A0A6B3G091_9ACTN/25-42               ........MIAQ.QT..R..NWWWTAHPAAH.
A0A4R4SIP9_9ACTN/1-18                ........MFAT.RI..S..SWWWTASPAAH.
A0A6H9UYC5_9ACTN/1-18                ........MFAH.SI..Q..NWWWTAHPAAH.
L1KMD2_9ACTN/1-20                    ........MFAH.ST..QnqNWWWTVLPAAH.
A0A6B3HXW4_9ACTN/25-42               ........MIAQ.QT..R..NWWWTAHPAAH.
A0A505DKE1_9ACTN/63-80               ........MFAH.SN..Q..TWWWTARPAAH.
A0A514K1C2_9ACTN/1-18                ........MFAH.SI..Q..NWWWTASPAAH.
A0A498E316_9ACTN/1-18                ........MFAQ.TT..R..DWWWTAHPAAH.
A0A6H0CK72_9ACTN/17-34               ........MFAP.SI..Q..NWWWTASPAAH.
A0A3S8X6N1_9ACTN/1-18                ........MFAH.ST..R..TWWWTALPAAH.
A0A5N8XW70_9ACTN/1-20                ........MFAH.PTqnQ..NWWWTAHPAAH.
A0A550HYJ6_9ACTN/24-37               .......p----.-I..Q..NWWWTAHPAAH.
A0A2M9K0D6_9ACTN/11-28               ........MFAH.TT..R..NWWWTAHPAAH.
A0A3A9Z578_9ACTN/1-18                ........MFAQ.HL..S..SWWWTAFPAAH.
A0A6N2I835_9ACTN/1-18                ........MFAQ.KN..Q..NWWWTAHPAAH.
A0A7H8IZ21_9ACTN/1-18                ........MHAR.QN..M..NWWWTAHPAAH.
A0A2R4TDZ7_9ACTN/1-18                ........MLAH.SI..Q..NWWWTAHPAA-r
A0A6G4VFT4_9ACTN/1-20                ........MFAH.ST..QnqNWWWTAHPAAH.
A0A371PWC6_9ACTN/19-34               ...pamnm----.--..-..NWWWTAHPAAH.
#=GC seq_cons                        ........MFAp.os..p..NWWWTAHPAAH.
//