#=GF ID V_ATPase_I_N
#=GF AC PF18670.5
#=GF DE V-type ATPase subunit I, N-terminal domain
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE ECOD:EUF08374
#=GF GA 25.00 25.00;
#=GF TC 25.70 28.20;
#=GF NC 23.50 23.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF WK V-ATPase
#=GF RN [1]
#=GF RM 21787787
#=GF RT Crystal structure of the cytoplasmic N-terminal domain of
#=GF RT subunit I, a homolog of subunit a, of V-ATPase.
#=GF RA Srinivasan S, Vyas NK, Baker ML, Quiocho FA;
#=GF RL J Mol Biol. 2011;412:14-21.
#=GF DR INTERPRO; IPR040574;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Vacuolar H+-ATPase (V-ATPase) is a ubiquitous multi-subunit
#=GF CC proton pump that acidifies a wide variety of intracellular
#=GF CC compartments, which in turn affects many biological processes,
#=GF CC including membrane trafficking, protein degradation and coupled
#=GF CC transport of small molecules and pH homeostasis. Subunit 'a' of
#=GF CC V0 (the functional domain responsible for proton transport)
#=GF CC sector is highly conserved across eukaryotic species and exists
#=GF CC in multiple isoforms. It is the largest subunit of V-ATPases and
#=GF CC partitioned almost equally into an N-terminal cytosolic domain
#=GF CC and a C-terminal integral membrane. Structure analysis of the
#=GF CC N-terminal cytosolic domain from the Meiothermus ruber subunit
#=GF CC 'I' homolog of subunit a shows that it is composed of a curved
#=GF CC long central alpha-helix bundle capped on both ends by two lobes
#=GF CC with similar alpha/beta architecture [1].
#=GF SQ 32
#=GS A0A511MZ16_DEIC1/115-204 AC A0A511MZ16.1
#=GS A0A0X8D7T0_9DEIN/116-204 AC A0A0X8D7T0.1
#=GS H8GU69_DEIGI/115-204 AC H8GU69.1
#=GS A0A177R5S4_9ACTN/120-219 AC A0A177R5S4.1
#=GS A0A2H5ZZ56_9BACT/117-209 AC A0A2H5ZZ56.1
#=GS C1CXT8_DEIDV/115-204 AC C1CXT8.1
#=GS E4U991_OCEP5/116-205 AC E4U991.1
#=GS F2NK91_MARHT/116-205 AC F2NK91.1
#=GS E8UBF2_DEIML/114-204 AC E8UBF2.1
#=GS A0A318S830_9DEIO/111-208 AC A0A318S830.1
#=GS VATI_DEIRA/115-204 AC Q9RWH3.1
#=GS A0A399EQL9_9DEIN/112-201 AC A0A399EQL9.1
#=GS A0A221SSW3_9DEIO/115-204 AC A0A221SSW3.1
#=GS L0A1V8_DEIPD/112-201 AC L0A1V8.1
#=GS A0A072NC09_9DEIO/115-204 AC A0A072NC09.1
#=GS A0A2Z3JBB4_9DEIO/116-206 AC A0A2Z3JBB4.1
#=GS A0A2H5ZS09_9BACT/121-213 AC A0A2H5ZS09.1
#=GS D7BEY8_MEISD/112-201 AC D7BEY8.1
#=GS A0A418V8Z4_9DEIO/115-204 AC A0A418V8Z4.1
#=GS A0A841I1S6_9DEIO/111-199 AC A0A841I1S6.1
#=GS A0A172TCF7_9DEIO/111-200 AC A0A172TCF7.1
#=GS Q1IWN8_DEIGD/115-204 AC Q1IWN8.1
#=GS D7CR03_TRURR/115-204 AC D7CR03.1
#=GS A0A1W1VQV8_9DEIO/111-200 AC A0A1W1VQV8.1
#=GS A0A399EGI5_9DEIN/113-202 AC A0A399EGI5.1
#=GS A0A2K3UXA5_9DEIO/115-204 AC A0A2K3UXA5.1
#=GS A0A0F7JRT9_9DEIO/111-200 AC A0A0F7JRT9.1
#=GS A0A7C9MAL7_9DEIO/111-201 AC A0A7C9MAL7.1
#=GS F0RIZ2_DEIPM/114-203 AC F0RIZ2.1
#=GS A0A399FAD7_9DEIN/117-206 AC A0A399FAD7.1
#=GS Q5SIT6_THET8/116-204 AC Q5SIT6.1
#=GS A0A1U7NXH1_9DEIO/116-206 AC A0A1U7NXH1.1
A0A511MZ16_DEIC1/115-204 .q-SFADVVKALAEVA...QGLDASR....RLSVIPFTLDAK..Q..D..AGLLQQTLQS....DLKDRFAM.DFKNV.GNL....R.AG.VVVV.KNQDRDVARQALSRARVGELRL....
A0A0X8D7T0_9DEIN/116-204 ..QAYLEPLERLAALA...HGLDKSP....FLRVIPFLLTEK..E..-..LPLVEEALKK....ALEDRYLL.VHEAY.GGG....V.AA.LVVV.HRKEVDQAKAALSRAGVAELRL....
H8GU69_DEIGI/115-204 .s-AYGDAVRALARMV...GNLSGSR....RLGLVPFLMQAT..D..N..PADLEAALRE....VLPERYAL.ATEAV.GGN....R.VG.VIVT.LRGERDAARAALSRVRLGELRL....
A0A177R5S4_9ACTN/120-219 pr--YIEPLRQLLPLVpelAELDESEiqalQLNAVALVLNTI..E..EtvVDVLRDALHT....ELGDRFVLvAVRVV.PDA....I.GC.VIVT.PASAAEGVQAVLGRERVR----plpl
A0A2H5ZZ56_9BACT/117-209 .r-SYEGAVRVLSPLL...AALQGSR....HLETYGFVLRGKpqA..A..VAALHQELRR....ITGGRVEV.VAHQI.DEK....T.TG.VVVAfHRRDAEAVRAFLQRAGITELRL....
C1CXT8_DEIDV/115-204 ..RAYGDVVRALARMV...GGLSRSR....RVALVPFLLSPA..D..N..ASELDAALRE....ALADRYEM.AMESV.GAN....R.VG.VIAT.LRGERDAARAALSRVRLGELRL....
E4U991_OCEP5/116-205 .d-LYQQPVETLAEMA...HGLDTSR....WLAVLPFLLEKE..S..E..LEVAAEALGE....ALEDRYVL.AHQPL.DGR....V.AA.LAVV.LQGDLETARGALSRKGIGELRL....
F2NK91_MARHT/116-205 .d-QFQKPVEALAELA...HGLDESR....WLAVIPFQLEKE..E..E..LGAVERALEE....ALEGRAVV.AAEPV.AGR....L.AV.VVVV.LKRDLEAARSALSRLGIGELRL....
E8UBF2_DEIML/114-204 .g-TYGQVTQALATLA...GGVDRSR....RLAVIPFTMQVG..D.aG..LNDLNAALNA....DLKDRYAL.DTRTV.GNN....V.VG.LVVV.PLADRDRARAALGKARVGELRL....
A0A318S830_9DEIO/111-208 .l-TFGEVVRTLANLA...GVLDRSR....RIALLPFTARED..D..D..LKALDAVLSDqqsgNLAGRYAL.ETRKV.NTGktevY.AG.LLAV.LREDRDKARAALGKARLGELRL....
VATI_DEIRA/115-204 ..RTYGDAVRALARMV...GTLDRSR....RVALVPFLIGAT..E..N..LGELDGALRE....SLGDRYTV.ASEVV.GAN....R.VG.VIAT.LSADRDAARAALSKARLGELRL....
A0A399EQL9_9DEIN/112-201 .q-LFGAAAQALAGLT...YGIDQSP....RFGVVPFLVGKP..E..E..LLPVRSALDS....ALQDRYLL.ESAPM.DKQ....V.AA.VVVV.MRRDLEAARSALSRLGLAELRF....
A0A221SSW3_9DEIO/115-204 .r-SYGDAIRALARMV...GGLDRSR....RVALVPFVLAPT..D..D..AATLDAALRE....TLAERYTL.ATETV.GNN....R.VG.VIAT.LRGDRDAARAALSKARLGELRL....
L0A1V8_DEIPD/112-201 ..RTYGDVVRALAELA...SGLDRSR....RMAVLPFVLPKN..E..G..VGELERVLRQ....DLEERFAL.DTRVV.GNV....T.AG.VVVA.LARERDKARAALGKARIGELRL....
A0A072NC09_9DEIO/115-204 .a-AYGDAVRTLARLA...GGVDRSR....RLAVVPFVLQLN..D..S..LAELEAALRS....TLEDRYAL.ATDVA.GPN....R.VG.LIAT.LRGDRDAARAALSRVRLGELRL....
A0A2Z3JBB4_9DEIO/116-206 ..RTYGPAVKALSDLS...GGLDRSR....RVSLVPFIYQKP..E..E..LAALQAALQA....SLEGRFEL.ATRPLsGSD....F.VG.AVAT.LTIDRDAARAALGKARLGELRL....
A0A2H5ZS09_9BACT/121-213 .r-SYEGAVRVLSPLL...AALRGSR....HFETYGFVLRGK..AmpA..VAALQRELER....ITGGRVEV.VARQI.DEK....N.IG.VVVAfHRRDGEAVRSFLQRAGITELRL....
D7BEY8_MEISD/112-201 ..QLFGSVAERLAGLT...HGLDQSQ....RLAVIPFLVSKI..E..E..LEPVRAALQA....SLEDRFLL.ESEAL.PNQ....I.AA.VVVV.LRRDLEAARTALSRQGLAELRF....
A0A418V8Z4_9DEIO/115-204 .r-SYGEAVRALSRMV...GGLDRSR....RLALLPFLLQPS..D..N..IAELDAALRE....ALPERYAI.ATEPV.GQN....R.VG.VIAA.LKSERDLARAALGRVRLGELRL....
A0A841I1S6_9DEIO/111-199 ..RAYADTVRVVGRLA...AGLDRSP....RFAVLPFTAPAE..D..-..LSRLRAALTE....ALGERYAF.EAAPA.GGN....Q.AG.VVAV.LRSDRDTARAALVRGGAGELRL....
A0A172TCF7_9DEIO/111-200 .a-AYGPAVRALSHIV...GGLDRSR....RVSLVPFLLQPT..D..N..VAELDAALQG....SLKDRYLL.ATEPV.GQN....R.VG.VIAT.LRGERDAARTALGKVRLGELRL....
Q1IWN8_DEIGD/115-204 .a-AYGDAVRALARLG...GGLDHSR....RLSLVPFVLQPS..D..Q..LDELEAALKT....ALPDRYAL.ATETV.GAN....R.VG.LIAV.LRADRDAARAALSRARLGELRL....
D7CR03_TRURR/115-204 ..NTYLPPFRELAPTL...AQLEGSR....YLRGAAFLVPSE..D..F..LSRVRAALKE....TFDNRFAL.ATRRY.GKG....F.LA.VVAV.LKGELSELQALLSRLGLAELQL....
A0A1W1VQV8_9DEIO/111-200 .a-AYGDAVRALARLA...GGLDRSR....RLALVPFVLQPT..D..N..LGELEAALRA....ALPDRYAL.TAETV.GNN....R.VG.LIAT.LRSERDLARSALGRVRLGELRL....
A0A399EGI5_9DEIN/113-202 .e-LFGKAAERLAEMV...QGLDQSR....WLAVLPFLVAKL..E..E..LEPVRAALQQ....GLSDRFVL.EAEPL.DNQ....V.LA.VLVV.RREELEAARSALSRLGLAELRF....
A0A2K3UXA5_9DEIO/115-204 .s-AYGGAVRALARLA...GGLDRSR....RLSVVPFLLQPS..D..A..PGDLEAALNS....ALEGRYAL.ATETV.GQN....R.VG.VIAT.LRNERDLARAALSKARLGELRL....
A0A0F7JRT9_9DEIO/111-200 .s-AYGDAVRALGRMA...GSLDRSQ....RVSLLPFVLQAT..D..N..SGELDAALKA....ELADRYVL.ATETV.GAN....R.VG.LIAT.RRSERDLARAALGKVRLGELRL....
A0A7C9MAL7_9DEIO/111-201 .r-SYGEVVSALARAA...GGLDRSA....RLSLLPLTVETA..A..E..LQAAQNALEA....ELPGRFAL.GTERV.SDR....L.TAvVVAV.LRTERDRARVALGKARLGELRL....
F0RIZ2_DEIPM/114-203 .a-AYAEPAATLARMV...GSLDRSR....RVAVIPFLLHAE..T..N..LGELQASLNE....ALGDRYEL.AVESS.GTG....R.VG.AVAT.LAGERDLARTALGRVRLAEMRL....
A0A399FAD7_9DEIN/117-206 .h-LFGKPAEKLAGLA...QGLDTSP....RLAVIPFLVSKA..E..E..LEAVREALQK....ALPDRFAL.DSDAL.DNQ....L.AV.VVVV.KRSDLELARSTLSRLGLAELR-y...
Q5SIT6_THET8/116-204 ..QAYLEPLERLAALA...HGLDKSP....FLRVIPFLLTEK..E..-..LPLVEEALRK....ALEDRYLL.AHEAY.AGG....V.AA.LVVV.HRKEVDQAKAALSRAGVAELRL....
A0A1U7NXH1_9DEIO/116-206 ..RTYGDTVTALSRAA...GTLDRST....RVTLIPLTVEKS..E..E..LAAAQDALKS....ELGDRFAI.GTERI.GQQ....StAV.VVAV.LRADRDRARAALGKARLGELRL....
#=GC seq_cons .t.sYGcsV+sLAcls...uGLD+SR....RlullPFllptp..-..p..LutLcuALcp....sLt-RasL.ss-sl.Gss....h.sG.Vlss.LRs-RDtARAALuRsRLGELRL....
//
