#=GF ID   V_ATPase_prox
#=GF AC   PF18274.5
#=GF DE   Vacuolar ATPase Subunit I N-terminal proximal lobe
#=GF AU   Smart A;0000-0002-6965-5633
#=GF SE   ECOD:EUF05423
#=GF GA   27.00 27.00;
#=GF TC   45.20 62.20;
#=GF NC   25.50 23.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF WK   V-ATPase
#=GF RN   [1]
#=GF RM   21787787
#=GF RT   Crystal structure of the cytoplasmic N-terminal domain of
#=GF RT   subunit I, a homolog of subunit a, of V-ATPase.
#=GF RA   Srinivasan S, Vyas NK, Baker ML, Quiocho FA;
#=GF RL   J Mol Biol. 2011;412:14-21.
#=GF DR   INTERPRO; IPR041276;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain is found in the cytoplasmic N-terminal domain of
#=GF CC   vacuolar ATP synthase subunit I present in Meiothermus ruber.
#=GF CC   Subunit I is a homolog of subunit A which associates with the
#=GF CC   membrane-bound complex of eukaryotic vacuolar H+-ATPase
#=GF CC   (V-ATPase) acidification machinery. The domain forms the
#=GF CC   proximal lobe that caps one end of the alpha helix bundle, with
#=GF CC   the distal lobe capping the other end. Although the two lobes
#=GF CC   exhibit a similar motif, the molecular nature of the coupling
#=GF CC   with the identical stalks is thought to be dissimilar [1].
#=GF SQ   8
#=GS A0A399EQL9_9DEIN/1-52  AC A0A399EQL9.1
#=GS A0A0X8D7T0_9DEIN/5-56  AC A0A0X8D7T0.1
#=GS F2NK91_MARHT/5-56      AC F2NK91.1
#=GS A0A399EGI5_9DEIN/1-52  AC A0A399EGI5.1
#=GS D7BEY8_MEISD/1-52      AC D7BEY8.1
#=GS E4U991_OCEP5/5-56      AC E4U991.1
#=GS Q5SIT6_THET8/5-56      AC Q5SIT6.1
#=GS A0A399FAD7_9DEIN/5-56  AC A0A399FAD7.1
A0A399EQL9_9DEIN/1-52             MEKLVVAGPRRLARSLLAELQHAGVVHIDPLRPAELGEFRLSPQEESELRRW
A0A0X8D7T0_9DEIN/5-56             MEKLVLAGPKGRAKELLQSLQQAGVVHLETLRPEALSAYQLSPEERAELRRW
F2NK91_MARHT/5-56                 MEKLVVAGPKRLARELLAELQRVGVVHLDPLEVEELSAYRLSKDEEDQLRRW
A0A399EGI5_9DEIN/1-52             MEKLVVAGPKRLARALLAELQKAGVVHIDPLRPDELGEYRLSPTEEAELRRW
D7BEY8_MEISD/1-52                 MEKLMVAGPKRLAKELLAELQRAGVVHIEPLRTEELGEYRLSADEDGELRRW
E4U991_OCEP5/5-56                 MEKLIVAGPKRRVHELLGELQRIGVVQIDALRTEELPEYAYSPEEEDAAKRW
Q5SIT6_THET8/5-56                 MEKLVLAGPKGRAKELLQSLQQAGVVHLETLRPEALSAYQLSPEERAELRRW
A0A399FAD7_9DEIN/5-56             VEKLIVVGPKRLARELLAELQRAGVVHLDPLRPEELGEYRLSPAEEAELRRW
#=GC seq_cons                     MEKLVVAGPKRLA+ELLAELQ+AGVVHlDPLRPEELuEYRLSP-EEuELRRW
//