#=GF ID Vac_Fusion
#=GF AC PF02346.20
#=GF DE Chordopoxvirus multifunctional envelope protein A27
#=GF AU Bashton M;0000-0002-6847-1525
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Pfam-B_822 (release 5.2)
#=GF GA 24.00 24.00;
#=GF TC 24.00 24.00;
#=GF NC 23.90 23.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 2389560
#=GF RT Vaccinia virus induces cell fusion at acid pH and this activity
#=GF RT is mediated by the N-terminus of the 14-kDa virus envelope
#=GF RT protein.
#=GF RA Gong SC, Lai CF, Esteban M;
#=GF RL Virology 1990;178:81-91.
#=GF RN [2]
#=GF RM 23990784
#=GF RT Crystal structure of vaccinia viral A27 protein reveals a novel
#=GF RT structure critical for its function and complex formation with
#=GF RT A26 protein.
#=GF RA Chang TH, Chang SJ, Hsieh FL, Ko TP, Lin CT, Ho MR, Wang I, Hsu
#=GF RA ST, Guo RT, Chang W, Wang AH;
#=GF RL PLoS Pathog. 2013;9:e1003563.
#=GF DR INTERPRO; IPR003436;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This is a family of viral fusion proteins from the
#=GF CC chordopoxviruses. Swiss:P26312 a 14-kDa Vaccinia Virus protein
#=GF CC has been demonstrated to function as a viral fusion protein
#=GF CC mediating cell fusion at endosmomal (low) pH [1]. More recently
#=GF CC it has been shown that A27 forms disulfide-linked protein
#=GF CC complexes with A26 protein providing an anchor for A26 protein
#=GF CC packaging into mature virions. A27 regulates virion-membrane
#=GF CC fusion rather than inducing it and is critical for the
#=GF CC successful egress of mature virus particles [2].
#=GF SQ 53
#=GS A27_VAR67/50-105 AC P33816.1
#=GS B2CWM2_9POXV/131-186 AC B2CWM2.1
#=GS A0A3F2YKS2_SHEVT/88-143 AC A0A3F2YKS2.1
#=GS Q9J542_FOWPN/412-467 AC Q9J542.1
#=GS Q98299_MCV1/478-533 AC Q98299.1
#=GS Q9DHJ6_YLDV/84-139 AC Q9DHJ6.1
#=GS D3IZQ2_9POXV/32-87 AC D3IZQ2.1
#=GS Q08FM6_DPV83/75-130 AC Q08FM6.1
#=GS Q1HTS0_9POXV/571-625 AC Q1HTS0.1
#=GS Q9JF68_VACCT/50-105 AC Q9JF68.1
#=GS Q90188_MONPV/50-105 AC Q90188.1
#=GS A0A0M3ZJQ6_9POXV/397-452 AC A0A0M3ZJQ6.1
#=GS Q98297_MCV1/423-478 AC Q98297.1
#=GS A0A220T6I9_9POXV/52-107 AC A0A220T6I9.1
#=GS A0A6B9R212_9POXV/393-450 AC A0A6B9R212.1
#=GS G3EI23_9POXV/39-94 AC G3EI23.1
#=GS A27_VACCW/50-105 AC P11258.3
#=GS Q08F56_DPV84/74-129 AC Q08F56.1
#=GS A0A223FNJ0_9POXV/55-110 AC A0A223FNJ0.1
#=GS Q9Q8I5_MYXVL/131-186 AC Q9Q8I5.1
#=GS A0A1L3IZP0_9POXV/193-232 AC A0A1L3IZP0.1
#=GS Q1HTR9_9POXV/12-66 AC Q1HTR9.1
#=GS A0A6B9R4Q9_9POXV/28-88 AC A0A6B9R4Q9.1
#=GS Q6TUQ2_YMTV5/87-142 AC Q6TUQ2.1
#=GS Q9JF72_VACCT/103-140 AC Q9JF72.1
#=GS A0A2U9QHS6_9POXV/432-474 AC A0A2U9QHS6.1
#=GS A0A2C9DT96_9POXV/476-531 AC A0A2C9DT96.1
#=GS Q8V3I2_SWPV1/85-140 AC Q8V3I2.1
#=GS A0A2C9DT95_9POXV/402-452 AC A0A2C9DT95.1
#=GS A0A097IVZ7_9POXV/192-233 AC A0A097IVZ7.1
#=GS Q6TVL6_ORFSA/31-86 AC Q6TVL6.1
#=GS A0A1W6S9U8_LSDV/88-143 AC A0A1W6S9U8.1
#=GS A0A223FMX7_9POXV/57-112 AC A0A223FMX7.1
#=GS A0A1B1MRN8_9POXV/540-594 AC A0A1B1MRN8.1
#=GS Q0NP60_9POXV/50-105 AC Q0NP60.1
#=GS A0A2U9QHW2_9POXV/48-103 AC A0A2U9QHW2.1
#=GS Q6VZ82_CNPV/413-468 AC Q6VZ82.1
#=GS Q0GNT5_HSPV/426-473 AC Q0GNT5.1
#=GS Q70GW8_FOWPV/411-466 AC Q70GW8.1
#=GS I6SMR9_9CAUD/37-89 AC I6SMR9.1
#=GS A26_VACCW/435-472 AC P24758.2
#=GS Q070A3_CPRVZ/385-437 AC Q070A3.1
#=GS A0A1V0S845_CNPV/409-464 AC A0A1V0S845.1
#=GS A0A7H0DNC4_MONPV/430-481 AC A0A7H0DNC4.1
#=GS A0A0M1JEJ3_9GAMM/97-162 AC A0A0M1JEJ3.1
#=GS Q775Q1_CAMPS/50-105 AC Q775Q1.1
#=GS F1AXD7_ORFV/31-86 AC F1AXD7.1
#=GS A27_VACCC/50-105 AC P20535.1
#=GS A0A223FMY9_9POXV/432-486 AC A0A223FMY9.1
#=GS H6TAA4_9POXV/192-233 AC H6TAA4.1
#=GS Q0GNT4_HSPV/50-105 AC Q0GNT4.1
#=GS A0A1B1MRG5_9POXV/39-94 AC A0A1B1MRG5.1
#=GS Q9Q8W3_RFVKA/121-176 AC Q9Q8W3.1
A27_VAR67/50-105 ...........................RLTNLEKKITNVTTKFEQIEKCCKRNDDVLFRLENHAETLRAAMISLAKKIDVQTG..........
B2CWM2_9POXV/131-186 ...........................DFKDIIIRLMVLEKLVQLTIKRQKRHNKAIRRIENHLETVRKGMLMLSKKIDAQTG..........
A0A3F2YKS2_SHEVT/88-143 ..........................q-IKDFVLRLVVLEKLFQTSVKECNSLKNIIKRLENHIETIRKNMIVLTKKVDFQTG..........
Q9J542_FOWPN/412-467 ..........................a-LRRLERRLGRIEQDHVEVAKSCSIVAEAIDRLERHADTLRHSMVNLAKKIDYQTG..........
Q98299_MCV1/478-533 ..........................l-IRELEDRVTTLAKDHTDVVNCCSTVSEGLSRLERHAETLRKTMLALVRKINVQTG..........
Q9DHJ6_YLDV/84-139 ...........................DVKKIVLRLLVLEKLFTLLFDKWSDSNDVIKRLEHHTDTVRKNMIILNKKIDVQTG..........
D3IZQ2_9POXV/32-87 ..........................s-KESIEGRLVDLLESYRTITECCRETGARLDRLERHLETLREALLKLNTKIDVQT-r.........
Q08FM6_DPV83/75-130 ..........................e-IKDFVLRLMVMEKILKISIERCKVLENTVKRLETHTETVRRNMLTLGKKIDVQTG..........
Q1HTS0_9POXV/571-625 ..........................p--KEVREEIEKLEKSLAKYRAECAKRQARLARLEHHIETMRQLTVILSHKADIQT-n.........
Q9JF68_VACCT/50-105 ...........................RLTNLEKKITNVTTKFEQIEKCCKRNDEVLFRLENHAETLRAAMISLAKKIDVQTG..........
Q90188_MONPV/50-105 ...........................RLTNLEKKITNITTKFEQIEKCCKRNDEVLFRLENHAETLRAAMISLAKKIDVQTG..........
A0A0M3ZJQ6_9POXV/397-452 ..........................q-LQALEDKINKVTSDHVEIAKSCNIVAETINRLERHADTLRLSMVNLARKIDIQTG..........
Q98297_MCV1/423-478 .......................rvqi----IQRQIRWLEHYLRNASKCCHENSRIESRLRHHLETMRQYSVLLSRKTDIQSG..........
A0A220T6I9_9POXV/52-107 ..........................r-LDKLEKRITDVINNFDELEKCCKRNSEVLSRLEEHAETLRKTMVALAIKIDLQTG..........
A0A6B9R212_9POXV/393-450 ikqinefikdlnddrvttnslflnild------------------------LQKERFYRLEHHLETMRQFSLILTRKVDRQ--s.........
G3EI23_9POXV/39-94 ...........................RLTNIEKKLNNITVKFSNIEKCCNKNEEVIYRLENHAETLRLTMLTLAKKIDIQTG..........
A27_VACCW/50-105 ...........................RLTNLEKKITNVTTKFEQIEKCCKRNDEVLFRLENHAETLRAAMISLAKKIDVQTG..........
Q08F56_DPV84/74-129 ..........................e-VKDFVLRLILMEKILKISIERCKVLENTVKRLETHTETVRRNMLTLGKKIDVQTG..........
A0A223FNJ0_9POXV/55-110 ...........................RLKNIETKLNNITTKFSQIEKCCKKNDEIIYRLENHAETLRLAMLALAKKIDVQTG..........
Q9Q8I5_MYXVL/131-186 ...........................DFKDIIIRLMVLEKLVQLTIKRQKRHNKAIRRIENHLETVRKGMLMLSKKIDAQTG..........
A0A1L3IZP0_9POXV/193-232 .......................dmdi--------------------KRLEVIDSDILRLENHFETIRRNMLTMAKKIDVQTG..........
Q1HTR9_9POXV/12-66 ......................tdrnr------ERLKRLLEEQERVIECCEHADDRLTRLEKHADTLRETMLKLARKIDVQTG..........
A0A6B9R4Q9_9POXV/28-88 .................cqevkqklsd----IDKIIDEIKSKYEELATLIGENEKTLTRLEDHGETLKNTLLQLAKKIDAQT-..........
Q6TUQ2_YMTV5/87-142 ...........................DVKKIVLRLLVLEKLFTLLFNKWSISNDIIKRLENHTDTIRKNMIILSKKIDVQTG..........
Q9JF72_VACCT/103-140 .................nfighyccdt---------------------------AAVDRLEHHIETLGQYAVILARKINMQT-..........
A0A2U9QHS6_9POXV/432-474 ......................plirh------------------LKDMCHRENNAAKKLEEHIETMRQYMIMTSQKVDHHT-c.........
A0A2C9DT96_9POXV/476-531 ..........................m-IKELETKIKKLIADHMRIGKCCSEVSDNLGRLEKHADTLRNTMLALVRKIDVQT-i.........
Q8V3I2_SWPV1/85-140 ...........................RIKDFILRLLVLEKIFQLSISNYKTLENSMKRVENHLETIRRNMITLTKKIDVQTG..........
A0A2C9DT95_9POXV/402-452 .............temqrvnrvmqsln-------------------SECCKGNRGKVSRLESHIETMRQYSVALSNKTDIQT-d.........
A0A097IVZ7_9POXV/192-233 ......................eidmd-------------------IKRLEVIDSDILRLENHFETIRRNMLTMAKKIDIQTG..........
Q6TVL6_ORFSA/31-86 .........................tk--ESVEERLVSLLDSYKTITDCCRETGNRLDRLEKHLETLRRALLDLNRKIDVQTG..........
A0A1W6S9U8_LSDV/88-143 ..........................q-IKDFVLRLLVLEKLFQTSVKECNSLKNIIKRLENHIETIRKNMIVLTKKVDFQTG..........
A0A223FMX7_9POXV/57-112 ...........................RLKNIETKLNNITAKFSQIEKCCKKNDEIIYRLENHAETLRVAMLALAKKIDIQTG..........
A0A1B1MRN8_9POXV/540-594 .............lnilkekiagyipl---------------IKHLKDTCKKENDAAKKLEHHIETMRQYMVMASNKVDYHT-c.........
Q0NP60_9POXV/50-105 ...........................RLTNLEKKITNVTIKFEQIEKCCKRNDEVLFRLENHAETLRAAMISLAKKIDVQTG..........
A0A2U9QHW2_9POXV/48-103 ..........................r-ISMLEKTVNDLLDTHTELIRCCSEAEDRMRRLETHASTLRSSILNLTTKIDVQTG..........
Q6VZ82_CNPV/413-468 ..........................a-LKRLERRLARVEQDHVEVAKSCSIVAETLDRLERHADTLRQSMVNLAKKIDYQTG..........
Q0GNT5_HSPV/426-473 ........hilntldhnlnsighyccd--------------------------TAAVDRLEHHIETLGQYAVILARKINMQT-..........
Q70GW8_FOWPV/411-466 ..........................a-LRRLERRLGRIEQDHVEVAKSCSILAEAIDRLERHADTLRHSMVNLAKKIDYQTG..........
I6SMR9_9CAUD/37-89 .........................gy--EDMCDRYFELRKDFRKAIESCKTQSETIKVMERTIDMLRKGVIGIER-------nsdi......
A26_VACCW/435-472 .................nfighyccdt---------------------------AAVDRLEHHIETLGQYAVILARKINMQT-..........
Q070A3_CPRVZ/385-437 .....................yqsfde-------DINEVLDKVVQVADTHENSTNANVRQDGHLETIRKILVALNNKID----rv........
A0A1V0S845_CNPV/409-464 ..........................a-LKRLERRLNRIEQDHVEVAKSCSIVAEAIDRLERHADTLRQSMVNLAKKIDYQTG..........
A0A7H0DNC4_MONPV/430-481 ...rldnhilntldhnlnsighyccdt---------------------------VAVDRLEHHIETLGQYTVILARKINMQT-..........
A0A0M1JEJ3_9GAMM/97-162 .........ldslkerlnvlqsdpent-----RNKLINLQAEHQNLQRQCTQNNESRQRLERELETIRRT-------------aadavkinnd
Q775Q1_CAMPS/50-105 ...........................RLTNLEKKITNVTTKFEQIEKCCKRNDEVLFRLENHAETLRAAMISLAKKIDVQTG..........
F1AXD7_ORFV/31-86 .........................tk--ESVEERLVSLLDGYKNITDCCRETGNRLDRLERHLESLRKALLDLNRKIDVQTG..........
A27_VACCC/50-105 ...........................RLTNLEKKITNVTTKFEQIEKCCKRNDEVLFRLENHAETLRAAMISLAKKIDVQTG..........
A0A223FMY9_9POXV/432-486 .......................drma----LNNRIINILDKNLNTLGSYCCDSESVKRLQYHIETLGQYALILTRKINIQ--s.........
H6TAA4_9POXV/192-233 ......................eidmd-------------------IKRLEVIDSDILRLENHFETIRRNMLTMAKKIDIQTG..........
Q0GNT4_HSPV/50-105 ...........................RLTNLEKKITNVTTKFEQIEKCCKRNDEVLFRLENHAETLRAAMISLAKKIDVQTG..........
A0A1B1MRG5_9POXV/39-94 ........................rls---LLEKTVTDLLDTYKDLIKCTGAAEERMRRLEGHAASLRASILHLTHKIDVQTG..........
Q9Q8W3_RFVKA/121-176 ..........................s-LKDLILRLMVLEKLVRLTVKRQKKNNKSIHRIENHLETVRKGMLMLSKKIDAQTG..........
#=GC seq_cons .............................ppl.h+lh.ltp.applhcsCppsscslpRLEpHhETLRpsMlsLu+KIDlQTG..........
//
