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Database: Pfam
Entry: Vpu
LinkDB: Vpu
Original site: Vpu 
#=GF ID   Vpu
#=GF AC   PF00558.21
#=GF DE   Vpu protein
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Swiss-Prot
#=GF GA   24.00 24.00;
#=GF TC   24.00 24.30;
#=GF NC   23.90 23.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   9338017
#=GF RT   Enhancement of retroviral production from packaging cell lines
#=GF RT   expressing the human immunodeficiency type 1 VPU gene. 
#=GF RA   Kobinger GP, Mouland AJ, Lalonde JP, Forget J, Cohen EA; 
#=GF RL   Gene Ther 1997;4:868-874.
#=GF RN   [2]
#=GF RM   7853484
#=GF RT   The human immunodeficiency virus type 1 Vpu protein specifically
#=GF RT   binds to the cytoplasmic domain of CD4: implications for the
#=GF RT   mechanism of degradation. 
#=GF RA   Bour S, Schubert U, Strebel K; 
#=GF RL   J Virol 1995;69:1510-1520.
#=GF RN   [3]
#=GF RM   9182993
#=GF RT   Secondary structure and tertiary fold of the human
#=GF RT   immunodeficiency virus protein U (Vpu) cytoplasmic domain in
#=GF RT   solution. 
#=GF RA   Willbold D, Hoffmann S, Rosch P; 
#=GF RL   Eur J Biochem 1997;245:581-588.
#=GF DR   INTERPRO; IPR008187;
#=GF DR   SCOP; 1vpu; fa;
#=GF DR   TC; 1.A.40;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   The Vpu protein contains an N-terminal transmembrane spanning
#=GF CC   region and a C-terminal cytoplasmic region. The HIV-1 Vpu
#=GF CC   protein stimulates virus production by enhancing  the release of
#=GF CC   viral particles from infected cells. The VPU protein binds
#=GF CC   specifically to CD4.
#=GF SQ   28
#=GS VPU_HV1MA/1-80            AC P05924.1
#=GS C7TQ78_9HIV1/1-81         AC C7TQ78.1
#=GS VPU_SIVEK/1-76            AC Q1A244.1
#=GS Q9YX50_9HIV1/1-78         AC Q9YX50.1
#=GS Q9Q6V9_9HIV1/1-76         AC Q9Q6V9.1
#=GS K4ITD9_9PLVG/1-80         AC K4ITD9.1
#=GS VPU_HV1VI/1-79            AC Q9QSQ8.1
#=GS A0A1I7FJF7_9CLOT/5-86     AC A0A1I7FJF7.1
#=GS VPU_HV1ET/1-84            AC Q75007.1
#=GS VPU_HV1B1/1-81            AC P69699.1
#=GS VPU_HV1B1/1-81            DR PDB; 2JPX A; 5-27;
#=GS VPU_HV1B1/1-81            DR PDB; 2N28 A; 1-81;
#=GS A0A4S2DGY4_9CLOT/6-88     AC A0A4S2DGY4.1
#=GS VPU_HV1YF/1-81            AC O91085.1
#=GS VPU_SIVCZ/1-88            AC P17286.1
#=GS VPU_HV190/1-78            AC O70901.1
#=GS VPU_HV1B9/1-79            AC Q89843.1
#=GS VPU_SIVMB/1-80            AC Q1A262.1
#=GS K1QEQ8_CRAGI/25-101       AC K1QEQ8.1
#=GS VPU_HV1JR/1-79            AC P20882.1
#=GS C7TQ96_9HIV1/1-79         AC C7TQ96.1
#=GS VPU_HV192/3-83            AC O12163.1
#=GS VPU_HV1H2/1-81            AC P05919.1
#=GS VPU_HV1H2/1-81            DR PDB; 2N29 A; 1-54;
#=GS VPU_HV1A2/1-81            AC P05949.2
#=GS VPU_HV1AN/1-85            AC Q77376.1
#=GS A0A430A1H8_9ENTE/1-79     AC A0A430A1H8.1
#=GS A0A1S3HY80_LINUN/236-299  AC A0A1S3HY80.1
#=GS Q90VU8_9HIV1/1-80         AC Q90VU8.1
#=GS VPU_HV1EL/1-80            AC P05925.1
#=GS VPU_HV1MV/1-85            AC Q79669.1
VPU_HV1MA/1-80                       ........qpl----VILA.IVALVVTLII.AIVVWTI....VFIEIRKIRRQ.....RKIDRLIDRIRERAE..DSGNESEGDTEE-LSKLVE-....MGHDAPWD--vddl..................
C7TQ78_9HIV1/1-81                    .....mkpplv------FS.TIVVIVAAIIpTIVVWFV....VIIDYRIIIQR.....RIIDWLLKIINNTAD..SSNNXSDGTTEE-LSA-VEK....RGHHHPGD--nnv...................
VPU_SIVEK/1-76                       ...........MLLLIKLG.FIGLAIETLI.VIVVWAI....VYRIYREVKVE.....EKISQLRQRIRDRAE..DSGNESDGDAEE-LANLL--....----------ppdridqd..............
Q9YX50_9HIV1/1-78                    ...........MLFWEIWA.IVGLVVALII.VIVVWTL....VFIEYKKLRRQ.....RRIDSLYNRIRERAE..DSGNESDGDAEE-LSTLVG-....MGNFDPW---vg....................
Q9Q6V9_9HIV1/1-76                    ...........MQSLAIAA.IVALVVVGII.AIVVGSI....VFIEYRKILRQ.....RKIDRLIDRIRERAE..DSGNESEGDQEA----LME-....MGHLVPW---dad...................
K4ITD9_9PLVG/1-80                    .....mlyidy-----RVG.IIALVVALIL.AIIVWTI....VYIEYRKLVRQ.....RKIDWLIERIRERAE..DSGNESEGDTEE-LSTMVD-....MGRLRLLD--vn....................
VPU_HV1VI/1-79                       ...........MSYLLAIG.IAALIVALII.AIVVWTI....VYIEYKKLVRQ.....RKINKLYKRIRERAE..DSGNESEGDAEE-LAALGE-....MGPFIPGD--in....................
A0A1I7FJF7_9CLOT/5-86                ......fgatc-----IVG.IICMIVFMFI.GIWLFIV....ALKAYNQFKYKny.ilEKINQNLSKLSKNND..DSIDDFDFEYDEMLNK----....----------kgdlassledi...........
VPU_HV1ET/1-84                       mvdllakvdyr------IV.IVAFIVALII.AIVVWTI....AYIEYRKLLRQ.....RRIDRLIKRTRERAE..DSGNESDGDTEE-LSTMVD-....MGNLRLLD--vn....................
VPU_HV1B1/1-81                       .........mq--PI-QIA.IVALVVAIII.AIVVWSI....VIIEYRKILRQ.....RKIDRLIDRLIERAE..DSGNESEGEISA-LVEMGVE....MGHHAPWD--vddl..................
#=GR VPU_HV1B1/1-81            SS    .........--------SH.CHHHHHHHHH.HHHHHHH....HHHS-SS---H.....HHHHTHHHHHHHH-S..S--S---SHHHH-HHHHHHH....HSS--SS---S---..................
A0A4S2DGY4_9CLOT/6-88                ....kifqivf------YS.IGALFMLTFA.IIGVWAF...iIFNKYYKTKRIenyllEKIYQAINQITYKNN..SSLNENTDEDLLGLDNLLDE....N---------adne..................
VPU_HV1YF/1-81                       ........mls------LG.FIALGAAVSI.AVIVWAL....LYREYKKIKLQ.....EKIKHIRQRIREREE..DSGNESDGDAE---------....----------wldgdeewlvtllssskldqgn
VPU_SIVCZ/1-88                       ........mtl-----LVG.LVLILVGLIAwNICIWGYiikwGYRRYKRHRLE.....TEIERLNLILRERAE..DSGNESNGEEEERLEQLIHNynhnNHFANPMFDL......................
VPU_HV190/1-78                       ......myilg------LG.IGALVVTFII.AVIVWTI....VYIEYKKLVRQ.....KKIDRLIERIGERAE..DSGNESDGDTEE-LSKLME-....MGHLNLGY--va....................
VPU_HV1B9/1-79                       ...........MLSLQILA.IVALVVAAII.AIVVWSI....VFIEYRKILRQ.....RKIDRLIDRIREREE..DSGNESEGDQEE-LAALER-....-GHLAPWD--vdd...................
VPU_SIVMB/1-80                       .......mdiv----QQVGlLVVLIIELVI.VIVIWVK....VYKLCKEDRRQ.....KKIDRLIARIRERAE..DSGNESDGDTEE-LQDLIT-....-EGDNLM---higi..................
K1QEQ8_CRAGI/25-101                  .......ntav-----IVG.VVAAVVLAI-.LVVVFII....VFKRTRTTKPK.....DEMQGSEKRIQEREE..NAH-LRNGSENTGLTNIYEN....KE--------tddkpvl...............
VPU_HV1JR/1-79                       ...........MQPLQILA.IVALVVAGII.AIIVWSI....VLIEYRKILRQ.....RKIDRLIDKIRERAE..DSGNESEGDQEE-LSALVE-....RGHLAPWD--in....................
C7TQ96_9HIV1/1-79                    ...........MTPLQIYA.IVGLIVALIL.AIVVWSI....VLVEYKKILKQ.....RKIDRLLDRIRDRAE..DSGNESDGDTEE-LSALVE-....MGDHNPW---gyn...................
VPU_HV192/3-83                       ..eligridyr------LG.VGALIVALII.VIIVWTI....AYIEYRKLVRQ.....RRIDWLVKRIKERAE..DSGNESGGDTEE-LETMVD-....MGHLRLL---dg....................
VPU_HV1H2/1-81                       .......qpip-----IVA.IVALVVAIII.AIVVWSI....VIIEYRKILRQ.....RKIDRLIDRLIERAE..DSGNESEGEISA-LVEMGVE....MGHHAPWD--vddl..................
#=GR VPU_HV1H2/1-81            SS    .......XXXX-----XXX.XXXXXXXXXX.XXXXXXX....XXX-TTSS-SS.....GGGGGHHHHHHHHHH..TTSS--HHHHHH-HHHHHHH....TT-TTTTS--SS--..................
VPU_HV1A2/1-81                       ...........MQSLQILA.IVSLVVVAII.AIVVWTI....VLIEYRKILRQ.....RKIDRLFDRIREKAE..DSGNESERDQEE-LSALVE-....MGHLAPWD--vddl..................
VPU_HV1AN/1-85                       ...........MHHRDLLA.IIIISALLFI.NVILWGF....ILRKYLEQKEQdr.keREILERLRRIREIRD..DSDYESNGEEEQEVMDLVLS....HGFDNPMFE-p.....................
A0A430A1H8_9ENTE/1-79                .......mtpq-------I.MITFVVLLII.IYIIWKI....YTIFTENKKIN.....DNINQLKQRNKERRElfSPINEVDGLELDTINQLFHF....KGQFEL----fef...................
A0A1S3HY80_LINUN/236-299             .....vvavti------TL.AVAVVVLLVV.IVVVWRRa..aRIKETLQEKLQ.....QEISQLQEQIANIEP..AT-HNSDGDS----------....----------si....................
Q90VU8_9HIV1/1-80                    .......mqpi-----IVA.IVALVVAIII.AIVVWSI....VIIEYRKILRQ.....RKIDRLIDRLIERAE..DSGNESEGEVSA-LVEMGVE....MGHHAPWD--idd...................
VPU_HV1EL/1-80                       ...........MQPLGIIA.IAALVVAIIL.AIVVWTI....VFIEYRRIKKQ.....RRIDCLLDRITERAE..DSGNESEGDREK-LSKLVE-....MGHHAPWD--idd...................
VPU_HV1MV/1-85                       ...........MHQENLLA.LIALSALCLI.NVLIWLF....NLRIYLVQRKQdr.reQEILERLRRIKEIRD..DSDYESNEEEQQEVMELIHS....HGFANPMFEL......................
#=GC SS_cons                         .......XXXX-----XSH.CHHHHHHHHH.HHHHHHH....HHHSTTSS-SC.....HHHHCHHHHHHHHHC..TTSS--HCHHHH-HHHHHHH....CTSTTTTS--SS--..................
#=GC seq_cons                        ................hlu.IlALlVslII.sIVVWsI....VhIEY+Klh+Q.....RKIDcLlcRI+ERAE..DSGNES-GDpE-.LspLhc.....hGpht.h...ss....................
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