#=GF ID Vpu
#=GF AC PF00558.21
#=GF DE Vpu protein
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Swiss-Prot
#=GF GA 24.00 24.00;
#=GF TC 24.00 24.30;
#=GF NC 23.90 23.50;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 9338017
#=GF RT Enhancement of retroviral production from packaging cell lines
#=GF RT expressing the human immunodeficiency type 1 VPU gene.
#=GF RA Kobinger GP, Mouland AJ, Lalonde JP, Forget J, Cohen EA;
#=GF RL Gene Ther 1997;4:868-874.
#=GF RN [2]
#=GF RM 7853484
#=GF RT The human immunodeficiency virus type 1 Vpu protein specifically
#=GF RT binds to the cytoplasmic domain of CD4: implications for the
#=GF RT mechanism of degradation.
#=GF RA Bour S, Schubert U, Strebel K;
#=GF RL J Virol 1995;69:1510-1520.
#=GF RN [3]
#=GF RM 9182993
#=GF RT Secondary structure and tertiary fold of the human
#=GF RT immunodeficiency virus protein U (Vpu) cytoplasmic domain in
#=GF RT solution.
#=GF RA Willbold D, Hoffmann S, Rosch P;
#=GF RL Eur J Biochem 1997;245:581-588.
#=GF DR INTERPRO; IPR008187;
#=GF DR SCOP; 1vpu; fa;
#=GF DR TC; 1.A.40;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC The Vpu protein contains an N-terminal transmembrane spanning
#=GF CC region and a C-terminal cytoplasmic region. The HIV-1 Vpu
#=GF CC protein stimulates virus production by enhancing the release of
#=GF CC viral particles from infected cells. The VPU protein binds
#=GF CC specifically to CD4.
#=GF SQ 28
#=GS VPU_HV1MA/1-80 AC P05924.1
#=GS C7TQ78_9HIV1/1-81 AC C7TQ78.1
#=GS VPU_SIVEK/1-76 AC Q1A244.1
#=GS Q9YX50_9HIV1/1-78 AC Q9YX50.1
#=GS Q9Q6V9_9HIV1/1-76 AC Q9Q6V9.1
#=GS K4ITD9_9PLVG/1-80 AC K4ITD9.1
#=GS VPU_HV1VI/1-79 AC Q9QSQ8.1
#=GS A0A1I7FJF7_9CLOT/5-86 AC A0A1I7FJF7.1
#=GS VPU_HV1ET/1-84 AC Q75007.1
#=GS VPU_HV1B1/1-81 AC P69699.1
#=GS VPU_HV1B1/1-81 DR PDB; 2JPX A; 5-27;
#=GS VPU_HV1B1/1-81 DR PDB; 2N28 A; 1-81;
#=GS A0A4S2DGY4_9CLOT/6-88 AC A0A4S2DGY4.1
#=GS VPU_HV1YF/1-81 AC O91085.1
#=GS VPU_SIVCZ/1-88 AC P17286.1
#=GS VPU_HV190/1-78 AC O70901.1
#=GS VPU_HV1B9/1-79 AC Q89843.1
#=GS VPU_SIVMB/1-80 AC Q1A262.1
#=GS K1QEQ8_CRAGI/25-101 AC K1QEQ8.1
#=GS VPU_HV1JR/1-79 AC P20882.1
#=GS C7TQ96_9HIV1/1-79 AC C7TQ96.1
#=GS VPU_HV192/3-83 AC O12163.1
#=GS VPU_HV1H2/1-81 AC P05919.1
#=GS VPU_HV1H2/1-81 DR PDB; 2N29 A; 1-54;
#=GS VPU_HV1A2/1-81 AC P05949.2
#=GS VPU_HV1AN/1-85 AC Q77376.1
#=GS A0A430A1H8_9ENTE/1-79 AC A0A430A1H8.1
#=GS A0A1S3HY80_LINUN/236-299 AC A0A1S3HY80.1
#=GS Q90VU8_9HIV1/1-80 AC Q90VU8.1
#=GS VPU_HV1EL/1-80 AC P05925.1
#=GS VPU_HV1MV/1-85 AC Q79669.1
VPU_HV1MA/1-80 ........qpl----VILA.IVALVVTLII.AIVVWTI....VFIEIRKIRRQ.....RKIDRLIDRIRERAE..DSGNESEGDTEE-LSKLVE-....MGHDAPWD--vddl..................
C7TQ78_9HIV1/1-81 .....mkpplv------FS.TIVVIVAAIIpTIVVWFV....VIIDYRIIIQR.....RIIDWLLKIINNTAD..SSNNXSDGTTEE-LSA-VEK....RGHHHPGD--nnv...................
VPU_SIVEK/1-76 ...........MLLLIKLG.FIGLAIETLI.VIVVWAI....VYRIYREVKVE.....EKISQLRQRIRDRAE..DSGNESDGDAEE-LANLL--....----------ppdridqd..............
Q9YX50_9HIV1/1-78 ...........MLFWEIWA.IVGLVVALII.VIVVWTL....VFIEYKKLRRQ.....RRIDSLYNRIRERAE..DSGNESDGDAEE-LSTLVG-....MGNFDPW---vg....................
Q9Q6V9_9HIV1/1-76 ...........MQSLAIAA.IVALVVVGII.AIVVGSI....VFIEYRKILRQ.....RKIDRLIDRIRERAE..DSGNESEGDQEA----LME-....MGHLVPW---dad...................
K4ITD9_9PLVG/1-80 .....mlyidy-----RVG.IIALVVALIL.AIIVWTI....VYIEYRKLVRQ.....RKIDWLIERIRERAE..DSGNESEGDTEE-LSTMVD-....MGRLRLLD--vn....................
VPU_HV1VI/1-79 ...........MSYLLAIG.IAALIVALII.AIVVWTI....VYIEYKKLVRQ.....RKINKLYKRIRERAE..DSGNESEGDAEE-LAALGE-....MGPFIPGD--in....................
A0A1I7FJF7_9CLOT/5-86 ......fgatc-----IVG.IICMIVFMFI.GIWLFIV....ALKAYNQFKYKny.ilEKINQNLSKLSKNND..DSIDDFDFEYDEMLNK----....----------kgdlassledi...........
VPU_HV1ET/1-84 mvdllakvdyr------IV.IVAFIVALII.AIVVWTI....AYIEYRKLLRQ.....RRIDRLIKRTRERAE..DSGNESDGDTEE-LSTMVD-....MGNLRLLD--vn....................
VPU_HV1B1/1-81 .........mq--PI-QIA.IVALVVAIII.AIVVWSI....VIIEYRKILRQ.....RKIDRLIDRLIERAE..DSGNESEGEISA-LVEMGVE....MGHHAPWD--vddl..................
#=GR VPU_HV1B1/1-81 SS .........--------SH.CHHHHHHHHH.HHHHHHH....HHHS-SS---H.....HHHHTHHHHHHHH-S..S--S---SHHHH-HHHHHHH....HSS--SS---S---..................
A0A4S2DGY4_9CLOT/6-88 ....kifqivf------YS.IGALFMLTFA.IIGVWAF...iIFNKYYKTKRIenyllEKIYQAINQITYKNN..SSLNENTDEDLLGLDNLLDE....N---------adne..................
VPU_HV1YF/1-81 ........mls------LG.FIALGAAVSI.AVIVWAL....LYREYKKIKLQ.....EKIKHIRQRIREREE..DSGNESDGDAE---------....----------wldgdeewlvtllssskldqgn
VPU_SIVCZ/1-88 ........mtl-----LVG.LVLILVGLIAwNICIWGYiikwGYRRYKRHRLE.....TEIERLNLILRERAE..DSGNESNGEEEERLEQLIHNynhnNHFANPMFDL......................
VPU_HV190/1-78 ......myilg------LG.IGALVVTFII.AVIVWTI....VYIEYKKLVRQ.....KKIDRLIERIGERAE..DSGNESDGDTEE-LSKLME-....MGHLNLGY--va....................
VPU_HV1B9/1-79 ...........MLSLQILA.IVALVVAAII.AIVVWSI....VFIEYRKILRQ.....RKIDRLIDRIREREE..DSGNESEGDQEE-LAALER-....-GHLAPWD--vdd...................
VPU_SIVMB/1-80 .......mdiv----QQVGlLVVLIIELVI.VIVIWVK....VYKLCKEDRRQ.....KKIDRLIARIRERAE..DSGNESDGDTEE-LQDLIT-....-EGDNLM---higi..................
K1QEQ8_CRAGI/25-101 .......ntav-----IVG.VVAAVVLAI-.LVVVFII....VFKRTRTTKPK.....DEMQGSEKRIQEREE..NAH-LRNGSENTGLTNIYEN....KE--------tddkpvl...............
VPU_HV1JR/1-79 ...........MQPLQILA.IVALVVAGII.AIIVWSI....VLIEYRKILRQ.....RKIDRLIDKIRERAE..DSGNESEGDQEE-LSALVE-....RGHLAPWD--in....................
C7TQ96_9HIV1/1-79 ...........MTPLQIYA.IVGLIVALIL.AIVVWSI....VLVEYKKILKQ.....RKIDRLLDRIRDRAE..DSGNESDGDTEE-LSALVE-....MGDHNPW---gyn...................
VPU_HV192/3-83 ..eligridyr------LG.VGALIVALII.VIIVWTI....AYIEYRKLVRQ.....RRIDWLVKRIKERAE..DSGNESGGDTEE-LETMVD-....MGHLRLL---dg....................
VPU_HV1H2/1-81 .......qpip-----IVA.IVALVVAIII.AIVVWSI....VIIEYRKILRQ.....RKIDRLIDRLIERAE..DSGNESEGEISA-LVEMGVE....MGHHAPWD--vddl..................
#=GR VPU_HV1H2/1-81 SS .......XXXX-----XXX.XXXXXXXXXX.XXXXXXX....XXX-TTSS-SS.....GGGGGHHHHHHHHHH..TTSS--HHHHHH-HHHHHHH....TT-TTTTS--SS--..................
VPU_HV1A2/1-81 ...........MQSLQILA.IVSLVVVAII.AIVVWTI....VLIEYRKILRQ.....RKIDRLFDRIREKAE..DSGNESERDQEE-LSALVE-....MGHLAPWD--vddl..................
VPU_HV1AN/1-85 ...........MHHRDLLA.IIIISALLFI.NVILWGF....ILRKYLEQKEQdr.keREILERLRRIREIRD..DSDYESNGEEEQEVMDLVLS....HGFDNPMFE-p.....................
A0A430A1H8_9ENTE/1-79 .......mtpq-------I.MITFVVLLII.IYIIWKI....YTIFTENKKIN.....DNINQLKQRNKERRElfSPINEVDGLELDTINQLFHF....KGQFEL----fef...................
A0A1S3HY80_LINUN/236-299 .....vvavti------TL.AVAVVVLLVV.IVVVWRRa..aRIKETLQEKLQ.....QEISQLQEQIANIEP..AT-HNSDGDS----------....----------si....................
Q90VU8_9HIV1/1-80 .......mqpi-----IVA.IVALVVAIII.AIVVWSI....VIIEYRKILRQ.....RKIDRLIDRLIERAE..DSGNESEGEVSA-LVEMGVE....MGHHAPWD--idd...................
VPU_HV1EL/1-80 ...........MQPLGIIA.IAALVVAIIL.AIVVWTI....VFIEYRRIKKQ.....RRIDCLLDRITERAE..DSGNESEGDREK-LSKLVE-....MGHHAPWD--idd...................
VPU_HV1MV/1-85 ...........MHQENLLA.LIALSALCLI.NVLIWLF....NLRIYLVQRKQdr.reQEILERLRRIKEIRD..DSDYESNEEEQQEVMELIHS....HGFANPMFEL......................
#=GC SS_cons .......XXXX-----XSH.CHHHHHHHHH.HHHHHHH....HHHSTTSS-SC.....HHHHCHHHHHHHHHC..TTSS--HCHHHH-HHHHHHH....CTSTTTTS--SS--..................
#=GC seq_cons ................hlu.IlALlVslII.sIVVWsI....VhIEY+Klh+Q.....RKIDcLlcRI+ERAE..DSGNES-GDpE-.LspLhc.....hGpht.h...ss....................
//
