#=GF ID Vpu
#=GF AC PF00558.24
#=GF DE Vpu protein
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Swiss-Prot
#=GF GA 24.00 24.00;
#=GF TC 24.00 24.20;
#=GF NC 23.90 23.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -Z 81514348 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 9338017
#=GF RT Enhancement of retroviral production from packaging cell lines
#=GF RT expressing the human immunodeficiency type 1 VPU gene.
#=GF RA Kobinger GP, Mouland AJ, Lalonde JP, Forget J, Cohen EA;
#=GF RL Gene Ther 1997;4:868-874.
#=GF RN [2]
#=GF RM 7853484
#=GF RT The human immunodeficiency virus type 1 Vpu protein specifically
#=GF RT binds to the cytoplasmic domain of CD4: implications for the
#=GF RT mechanism of degradation.
#=GF RA Bour S, Schubert U, Strebel K;
#=GF RL J Virol 1995;69:1510-1520.
#=GF RN [3]
#=GF RM 9182993
#=GF RT Secondary structure and tertiary fold of the human
#=GF RT immunodeficiency virus protein U (Vpu) cytoplasmic domain in
#=GF RT solution.
#=GF RA Willbold D, Hoffmann S, Rosch P;
#=GF RL Eur J Biochem 1997;245:581-588.
#=GF DR INTERPRO; IPR008187;
#=GF DR SCOP; 1vpu; fa;
#=GF DR TC; 1.A.40;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC The Vpu protein contains an N-terminal transmembrane spanning
#=GF CC region and a C-terminal cytoplasmic region. The HIV-1 Vpu
#=GF CC protein stimulates virus production by enhancing the release of
#=GF CC viral particles from infected cells. The VPU protein binds
#=GF CC specifically to CD4.
#=GF SQ 39
#=GS C7TQ72_9HIV1/1-79 AC C7TQ72.1
#=GS VPU_HV1VI/1-79 AC Q9QSQ8.1
#=GS Q77Y20_9PLVG/1-81 AC Q77Y20.1
#=GS VPU_HV1BR/1-80 AC P05923.1
#=GS VPU_HV1A2/1-81 AC P05949.2
#=GS VPU_SIVEK/1-76 AC Q1A244.1
#=GS A0A3Q0CAM7_MESAU/35-102 AC A0A3Q0CAM7.1
#=GS VPU_HV1EL/1-80 AC P05925.1
#=GS A0A8K1C2R2_PYTOL/1-60 AC A0A8K1C2R2.1
#=GS VPU_HV1B1/1-81 AC P69699.1
#=GS VPU_HV1B1/1-81 DR PDB; 2JPX A; 5-27;
#=GS VPU_HV1B1/1-81 DR PDB; 2N28 A; 1-81;
#=GS C7TQA8_9HIV1/1-78 AC C7TQA8.1
#=GS VPU_HV1AN/1-85 AC Q77376.1
#=GS Q9Q6V9_9HIV1/1-76 AC Q9Q6V9.1
#=GS A0A4S2DGY4_9CLOT/6-88 AC A0A4S2DGY4.1
#=GS A0A8X6KZ43_TRICU/103-161 AC A0A8X6KZ43.1
#=GS Q9YX50_9HIV1/1-78 AC Q9YX50.1
#=GS K4ITD9_9PLVG/1-80 AC K4ITD9.1
#=GS A0A1I7FJF7_9CLOT/6-86 AC A0A1I7FJF7.1
#=GS VPU_HV1RH/1-81 AC P12518.2
#=GS VPU_HV192/6-83 AC O12163.1
#=GS C7TQ96_9HIV1/1-79 AC C7TQ96.1
#=GS VPU_HV193/1-79 AC O70891.1
#=GS C7TQ78_9HIV1/1-81 AC C7TQ78.1
#=GS VPU_HV1B9/1-80 AC Q89843.1
#=GS VPU_SIVMB/1-80 AC Q1A262.1
#=GS VPU_HV1JR/1-80 AC P20882.1
#=GS VPU_HV1H2/1-82 AC P05919.2
#=GS VPU_HV1H2/1-82 DR PDB; 2N29 A; 1-54;
#=GS VPU_SIVCZ/1-88 AC P17286.1
#=GS VPU_HV1ET/4-84 AC Q75007.1
#=GS A0A6H1WRT3_9BACT/348-401 AC A0A6H1WRT3.1
#=GS VPU_HV1MA/1-81 AC P05924.2
#=GS C7TQ90_9HIV1/1-78 AC C7TQ90.1
#=GS A0A430A1H8_9ENTE/1-79 AC A0A430A1H8.1
#=GS VPU_HV190/1-78 AC O70901.1
#=GS VPU_HV1YF/1-81 AC O91085.1
#=GS A0A975GEE6_9BACT/349-422 AC A0A975GEE6.1
#=GS A8E121_9HIV1/1-81 AC A8E121.1
#=GS E4RLB2_HALHG/19-91 AC E4RLB2.1
#=GS A0A6J4X3B1_9DELT/350-417 AC A0A6J4X3B1.1
C7TQ72_9HIV1/1-79 ..........MSPLEI..SAITGLVVALII.AIVVWSI....VIIEYRKILKQ.....RKIDRL...LDRIRDR.AE..DSGNESDGDAEE-LSALVE-....MGDHNPW---gyn...................
VPU_HV1VI/1-79 ..........MSYLLA..IGIAALIVALII.AIVVWTI....VYIEYKKLVRQ.....RKINKL...YKRIRER.AE..DSGNESEGDAEE-LAALGE-....MGPFIPGD--in....................
Q77Y20_9PLVG/1-81 ........mq--PI-Q..IAIVALVVAIII.AIVVWSI....VIIEYRKILRQ.....RKIDRL...IDRLIER.AE..DSGNESEGEISA-LVEMGVE....MGHHAPWD--vddl..................
VPU_HV1BR/1-80 ........mq--PI-Q..IAIAALVVAIII.AIVVWSI....VIIEYRKILRQ.....RKIDRL...IDRLIER.AE..DSGNESEGEISA-LVEMGVE....MGHHAPWD--idd...................
VPU_HV1A2/1-81 ..........MQSLQI..LAIVSLVVVAII.AIVVWTI....VLIEYRKILRQ.....RKIDRL...FDRIREK.AE..DSGNESERDQEE-LSALVE-....MGHLAPWD--vddl..................
VPU_SIVEK/1-76 ..........MLLLIK..LGFIGLAIETLI.VIVVWAI....VYRIYREVKVE.....EKISQL...RQRIRDR.AE..DSGNESDGDAEE-LANLL--....----------ppdridqd..............
A0A3Q0CAM7_MESAU/35-102 ......vghk------..VPLAVLCLLLMM.AISVWLV....YIFQYRQEKHNq...eKIINNL...YQKYYSI.KN..DS------------------....----------ylkeqnfnnkstecd.......
VPU_HV1EL/1-80 ..........MQPLGI..IAIAALVVAIIL.AIVVWTI....VFIEYRRIKKQ.....RRIDCL...LDRITER.AE..DSGNESEGDREK-LSKLVE-....MGHHAPWD--idd...................
A0A8K1C2R2_PYTOL/1-60 ..........MHELVLvkMMVTMLCIAILV.TIIIWTY....RYIQYRRAVRL.....SQMRWLhfeADKIFDD.TE..RS------------------....----------ln....................
VPU_HV1B1/1-81 ........mq--PI-Q..IAIVALVVAIII.AIVVWSI....VIIEYRKILRQ.....RKIDRL...IDRLIER.AE..DSGNESEGEISA-LVEMGVE....MGHHAPWD--vddl..................
#=GR VPU_HV1B1/1-81 SS ........--------..SHCHHHHHHHHH.HHHHHHH....HHHS-SS---H.....HHHHTH...HHHHHHH.-S..S--S---SHHHH-HHHHHHH....HSS--SS---S---..................
C7TQA8_9HIV1/1-78 ..........MNILQI..ASIVGLVVVSII.AIIVWAI....VFIEYKKLLKQ.....RKIDWL...VNRIKER.AE..DSGNESEGDTEE-LSTLVE-....MG--------dpdfwdv...............
VPU_HV1AN/1-85 ..........MHHRDL..LAIIIISALLFI.NVILWGF....ILRKYLEQKEQdr.keREILER...LRRIREI.RD..DSDYESNGEEEQEVMDLVLS....HGFDNPMFE-p.....................
Q9Q6V9_9HIV1/1-76 ..........MQSLAI..AAIVALVVVGII.AIVVGSI....VFIEYRKILRQ.....RKIDRL...IDRIRER.AE..DSGNESEGDQEA----LME-....MGHLVPW---dad...................
A0A4S2DGY4_9CLOT/6-88 ...kifqivf------..YSIGALFMLTFA.IIGVWAF...iIFNKYYKTKRIenyllEKIYQA...INQITYK.NN..SSLNENTDEDLLGLDNLLDE....N---------adne..................
A0A8X6KZ43_TRICU/103-161 ....viiggl------..--LGVILFILII.NIVIWAT....CFRKYKKRCEE.....SPTSTH...ERRIPEKiKA..DS------------------....----------detvmkd...............
Q9YX50_9HIV1/1-78 ..........MLFWEI..WAIVGLVVALII.VIVVWTL....VFIEYKKLRRQ.....RRIDSL...YNRIRER.AE..DSGNESDGDAEE-LSTLVG-....MGNFDPW---vg....................
K4ITD9_9PLVG/1-80 ....mlyidy-----R..VGIIALVVALIL.AIIVWTI....VYIEYRKLVRQ.....RKIDWL...IERIRER.AE..DSGNESEGDTEE-LSTMVD-....MGRLRLLD--vn....................
A0A1I7FJF7_9CLOT/6-86 ......gatc-----I..VGIICMIVFMFI.GIWLFIV....ALKAYNQFKYKny.ilEKINQN...LSKLSKN.ND..DSIDDFDFEYDEMLN-----....----------kkgdlassledi..........
VPU_HV1RH/1-81 ..........MQSLEI..LAIVALVVAAIL.AIVVWTI....VGIEIRKTLRQ.....KKIDRL...IDRIRER.AE..DSGNESDGDEEE-LSALVE-....MGHHAPWD--vddl..................
VPU_HV192/6-83 ....gridyr------..LGVGALIVALII.VIIVWTI....AYIEYRKLVRQ.....RRIDWL...VKRIKER.AE..DSGNESGGDTEE-LETMVD-....MGHLRLL---dg....................
C7TQ96_9HIV1/1-79 ..........MTPLQI..YAIVGLIVALIL.AIVVWSI....VLVEYKKILKQ.....RKIDRL...LDRIRDR.AE..DSGNESDGDTEE-LSALVE-....MGDHNPW---gyn...................
VPU_HV193/1-79 ..........MSNLLA..IGIAALIVALII.TIVVWTI....AYIEYKKLVRQ.....RKINRL...YKRISER.AE..DSGNESEGDAEE-LAALGE-....VGPFIPGD--in....................
C7TQ78_9HIV1/1-81 ....mkpplv------..FSTIVVIVAAIIpTIVVWFV....VIIDYRIIIQR.....RIIDWL...LKIINNT.AD..SSNNXSDGTTEE-LSA-VEK....RGHHHPGD--nnv...................
VPU_HV1B9/1-80 ..........MLSLQI..LAIVALVVAAII.AIVVWSI....VFIEYRKILRQ.....RKIDRL...IDRIRER.EE..DSGNESEGDQEE-LAALER-....-GHLAPWD--vddl..................
VPU_SIVMB/1-80 ...mdivqqv------..GLLVVLIIELVI.VIVIWVK....VYKLCKEDRRQ.....KKIDRL...IARIRER.AE..DSGNESDGDTEE-LQDLIT-....-EGDNLM---higi..................
VPU_HV1JR/1-80 ..........MQPLQI..LAIVALVVAGII.AIIVWSI....VLIEYRKILRQ.....RKIDRL...IDKIRER.AE..DSGNESEGDQEE-LSALVE-....RGHLAPWD--ind...................
VPU_HV1H2/1-82 ..........MQPIPI..VAIVALVVAIII.AIVVWSI....VIIEYRKILRQ.....RKIDRL...IDRLIER.AE..DSGNESEGEISA-LVEMGVE....MGHHAPWD--vddl..................
#=GR VPU_HV1H2/1-82 SS ..........XXXXXX..XXXXXXXXXXXX.XXXXXXX....XX-TTSS-SSG.....GGGGHH...HHHHHHH.HT..TSS--HHHHHHH-HHHHHHT....T-TTTTSS--S--X..................
VPU_SIVCZ/1-88 .......mtl-----L..VGLVLILVGLIAwNICIWGYiikwGYRRYKRHRLE.....TEIERL...NLILRER.AE..DSGNESNGEEEERLEQLIHNynhnNHFANPMFDL......................
VPU_HV1ET/4-84 ..llakvdyr------..IVIVAFIVALII.AIVVWTI....AYIEYRKLLRQ.....RRIDRL...IKRTRER.AE..DSGNESDGDTEE-LSTMVD-....MGNLRLLD--vn....................
A0A6H1WRT3_9BACT/348-401 .....ryvgn------..YGLAIILLTFLV.RIIFWPL....NHLSYKSMKKM.....QEIQPI...IQRLREK.YQ..D-------------------....----------dpq...................
VPU_HV1MA/1-81 ..........MQPLVI..LAIVALVVTLII.AIVVWTI....VFIEIRKIRRQ.....RKIDRL...IDRIRER.AE..DSGNESEGDTEE-LSKLVE-....MGHDAPWD--vddl..................
C7TQ90_9HIV1/1-78 ..........MPPLDI..AAIVGLIVALIL.AIIVWSI....VLIEYRKILKQ.....KKIDRL...LDRIRDR.AE..DSGNESDGDTEE-LSALVE-....MGNHNPW---gy....................
A0A430A1H8_9ENTE/1-79 ......mtpq------..-IMITFVVLLII.IYIIWKI....YTIFTENKKIN.....DNINQL...KQRNKER.RElfSPINEVDGLELDTINQLFHF....KGQFEL----fef...................
VPU_HV190/1-78 .....myilg------..LGIGALVVTFII.AVIVWTI....VYIEYKKLVRQ.....KKIDRL...IERIGER.AE..DSGNESDGDTEE-LSKLME-....MGHLNLGY--va....................
VPU_HV1YF/1-81 .......mls------..LGFIALGAAVSI.AVIVWAL....LYREYKKIKLQ.....EKIKHI...RQRIRER.EE..DSGNESDGDAE---------....----------wldgdeewlvtllssskldqgn
A0A975GEE6_9BACT/349-422 ....ytaipn------..YGLAIIILTIII.KIILWPL....GNKSYKSMNEM.....KKIQPL...MTEIREK.YK..DDKKKMN-------------....----------eelmglykiykinpmg......
A8E121_9HIV1/1-81 ..........MISLKT..ISIAALIVAFLI.VVVVWTI....VYIEYRKLLRQ.....KRIDRL...LERIRER.AE..DSGNESDGDTEE-LARLVE-....MGPHDLGN--dndl..................
E4RLB2_HALHG/19-91 ......ivgn------..YGLAIVIFTLII.KIVLYPL....TAKQTRSMREM.....QEIQPE...MKKIQNK.YE..DDK---EKQQEE-MMKLYKD....HGV-------npaag.................
A0A6J4X3B1_9DELT/350-417 mnklysvipn------..YGIAIIILTILI.KIVLWPL....GSKSYKSMSEM.....KKIQPL...MKEIREK.HK..H-------------------....----------dkkkmneevmgl..........
#=GC SS_cons ..........XXXXXX..SHCHHHHHHHHH.HHHHHHH....HHHTTSS-SSH.....HHHHCH...HHHHHHH.HT..TSSS-HHCHHHH-HHHHHHC....CSTTTTSS--S--X..................
#=GC seq_cons ..................huIsuLlVslII.sIlVWsI....lhIEY+Klh+Q.....+KI-pL...lcRI+ER.AE..DSGNES-G-tE-.Lsthhp.....hG.ht.h...sst...................
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