GenomeNet

Database: Pfam
Entry: XAF1_C
LinkDB: XAF1_C
Original site: XAF1_C 
#=GF ID   XAF1_C
#=GF AC   PF18608.1
#=GF DE   XIAP-associated factor 1 C-terminal domain
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF08690
#=GF GA   25.80 25.80;
#=GF TC   26.10 26.60;
#=GF NC   25.60 25.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   XIAP-associated factor 1 (XAF1) is a 301-amino acids interferon
#=GF CC   (INF)-inducible pro-apoptotic protein. The XIAP binding region
#=GF CC   within XAF1, XIAP RING binding site, is located at the
#=GF CC   C-terminal portion of XAF1. This entry represents the C-terminal
#=GF CC   region which is functionally identified as XIAP RING-binding
#=GF CC   domain of XAF1 [1].
#=GF SQ   90
#=GS H0XWK1_OTOGA/251-297      AC H0XWK1.1
#=GS L5MB26_MYODS/245-288      AC L5MB26.1
#=GS A0A091U9B0_PHORB/253-290  AC A0A091U9B0.1
#=GS A0A093DTS6_9AVES/240-277  AC A0A093DTS6.1
#=GS F7FLB6_ORNAN/243-293      AC F7FLB6.2
#=GS A0A287DAE0_ICTTR/229-269  AC A0A287DAE0.1
#=GS H0VZB1_CAVPO/237-285      AC H0VZB1.2
#=GS A0A091GUJ1_BUCRH/249-286  AC A0A091GUJ1.1
#=GS H9KX91_CALJA/79-126       AC H9KX91.1
#=GS XAF1_BOVIN/248-297        AC Q58DH1.2
#=GS Z4YN17_MOUSE/127-168      AC Z4YN17.1
#=GS W5NRX9_SHEEP/248-300      AC W5NRX9.1
#=GS A0A140T8C1_BOVIN/248-297  AC A0A140T8C1.1
#=GS A0A091CQG1_FUKDA/218-272  AC A0A091CQG1.1
#=GS U3IES3_ANAPL/106-143      AC U3IES3.1
#=GS U3KKM7_FICAL/12-47        AC U3KKM7.1
#=GS I3MGS8_ICTTR/229-282      AC I3MGS8.2
#=GS A0A1S3W911_ERIEU/239-287  AC A0A1S3W911.1
#=GS M0R7W3_RAT/127-174        AC M0R7W3.1
#=GS A0A286XMZ9_CAVPO/125-173  AC A0A286XMZ9.1
#=GS A0A1A6GU52_NEOLE/257-305  AC A0A1A6GU52.1
#=GS G1P611_MYOLU/245-297      AC G1P611.1
#=GS A0A093FT15_GAVST/242-295  AC A0A093FT15.1
#=GS H2QC14_PANTR/248-301      AC H2QC14.1
#=GS A0A2I3M658_PAPAN/229-282  AC A0A2I3M658.1
#=GS A0A2K5MKK4_CERAT/229-282  AC A0A2K5MKK4.1
#=GS A0A094KVR4_ANTCR/240-277  AC A0A094KVR4.1
#=GS A0A091FXX9_9AVES/238-266  AC A0A091FXX9.1
#=GS A0A1D5Q0P0_MACMU/248-301  AC A0A1D5Q0P0.1
#=GS A0A1U8BM14_MESAU/221-262  AC A0A1U8BM14.1
#=GS G1LKU7_AILME/173-226      AC G1LKU7.1
#=GS A0A091KL13_9GRUI/229-266  AC A0A091KL13.1
#=GS A0A093FYG1_DRYPU/253-290  AC A0A093FYG1.1
#=GS D3ZPQ3_RAT/221-268        AC D3ZPQ3.3
#=GS A0A1U8DML0_ALLSI/270-323  AC A0A1U8DML0.1
#=GS A0A099YXX8_TINGU/207-260  AC A0A099YXX8.1
#=GS W5NRX7_SHEEP/248-296      AC W5NRX7.1
#=GS A0A151N5M2_ALLMI/246-299  AC A0A151N5M2.1
#=GS A0A091Q0U2_LEPDC/245-282  AC A0A091Q0U2.1
#=GS W5JXN4_ASTMX/212-247      AC W5JXN4.1
#=GS A0A093FNH5_TYTAL/225-262  AC A0A093FNH5.1
#=GS A0A2K5JFV4_COLAP/248-301  AC A0A2K5JFV4.1
#=GS A0A1S3EX16_DIPOR/227-267  AC A0A1S3EX16.1
#=GS A0A091J2R3_CALAN/215-251  AC A0A091J2R3.1
#=GS A0A091NZ95_HALAL/236-273  AC A0A091NZ95.1
#=GS A0A0A0A8W6_CHAVO/244-297  AC A0A0A0A8W6.1
#=GS A0A091QFQ4_MERNU/179-216  AC A0A091QFQ4.1
#=GS A0A091VP79_NIPNI/241-278  AC A0A091VP79.1
#=GS A0A093QNA9_PHACA/236-273  AC A0A093QNA9.1
#=GS A0A2I3RXU7_PANTR/229-282  AC A0A2I3RXU7.1
#=GS A0A093NH94_PYGAD/231-268  AC A0A093NH94.1
#=GS A0A093K1G3_STRCA/239-276  AC A0A093K1G3.1
#=GS XAF1_MOUSE/222-271        AC Q5NBU8.3
#=GS A0A2I3HQ89_NOMLE/248-301  AC A0A2I3HQ89.1
#=GS G1SR91_RABIT/227-280      AC G1SR91.2
#=GS F6S8R0_HORSE/248-301      AC F6S8R0.1
#=GS A0A094LE93_9AVES/238-275  AC A0A094LE93.1
#=GS M7BV66_CHEMY/170-208      AC M7BV66.1
#=GS A0A087R078_APTFO/239-276  AC A0A087R078.1
#=GS A0A091MB15_CATAU/240-277  AC A0A091MB15.1
#=GS H2NSG1_PONAB/247-300      AC H2NSG1.2
#=GS S7MGX6_MYOBR/232-276      AC S7MGX6.1
#=GS G5B914_HETGA/240-293      AC G5B914.1
#=GS L9KET4_TUPCH/201-254      AC L9KET4.1
#=GS K7G1T1_PELSI/238-291      AC K7G1T1.1
#=GS A0A091SV66_9AVES/236-273  AC A0A091SV66.1
#=GS A0A2K5JFL8_COLAP/229-282  AC A0A2K5JFL8.1
#=GS A0A2I2Y2M5_GORGO/248-301  AC A0A2I2Y2M5.1
#=GS F1MQJ9_BOVIN/248-299      AC F1MQJ9.2
#=GS G1LKU4_AILME/187-232      AC G1LKU4.1
#=GS G3R991_GORGO/229-282      AC G3R991.2
#=GS XAF1_HUMAN/248-301        AC Q6GPH4.1
#=GS XAF1_HUMAN/248-301        DR PDB; 2LXW A; 5-55;
#=GS A0A1U7QKD2_MESAU/221-268  AC A0A1U7QKD2.1
#=GS A0A093SS05_9PASS/232-285  AC A0A093SS05.1
#=GS M3ZJD0_XIPMA/225-268      AC M3ZJD0.1
#=GS J9PBD0_CANLF/178-230      AC J9PBD0.1
#=GS A0A096P2L4_PAPAN/248-301  AC A0A096P2L4.1
#=GS A0A091JF57_EGRGA/234-271  AC A0A091JF57.1
#=GS A0A087Y2Z9_POEFO/221-265  AC A0A087Y2Z9.1
#=GS A0A2I3GU08_NOMLE/229-282  AC A0A2I3GU08.1
#=GS A0A2I0LYE5_COLLI/263-315  AC A0A2I0LYE5.1
#=GS A0A1S3EZR1_DIPOR/227-280  AC A0A1S3EZR1.1
#=GS A0A2K5MKJ5_CERAT/248-301  AC A0A2K5MKJ5.1
#=GS A0A1L1RRJ2_CHICK/236-289  AC A0A1L1RRJ2.1
#=GS A0A1U7UPM4_TARSY/247-300  AC A0A1U7UPM4.1
#=GS F7AC39_MACMU/229-282      AC F7AC39.1
#=GS A0A0D9RIW3_CHLSB/248-301  AC A0A0D9RIW3.1
#=GS A0A0A0A8N6_CHAVO/255-308  AC A0A0A0A8N6.1
#=GS G7PTE5_MACFA/249-302      AC G7PTE5.1
#=GS G3VUF7_SARHA/212-258      AC G3VUF7.1
H0XWK1_OTOGA/251-297                 .......ktr--TPSSVEEN.ETAYDILRSCSQCGILLPLPTLNQHQEKCWRLASSK--------.........
L5MB26_MYODS/245-288                 .........p-ERQPWVVDD.-PAYNILRRCPQCDILLPLPTLNQHQVPASALS-----------sp.......
A0A091U9B0_PHORB/253-290             .........l-STSPQALKD.TQSFDMLVTCAHCNILLPLPTLRKHEVR----------------.........
A0A093DTS6_9AVES/240-277             ........ly--TSPQAPKD.TQSFDMLVTCAHCNILLPLPTLQKHEVR----------------.........
F7FLB6_ORNAN/243-293                 .........q-SWGPPAPRD.ESEFDVLDSCPQCRILLPKPTLHLHQKKCLFLASLKNRK-----ln.......
A0A287DAE0_ICTTR/229-269             ..........KPRTAFPTED.EAAYDILRRCSQCGILLPLPTLCQHQ------------------qvkia....
H0VZB1_CAVPO/237-285                 .......gsg---AASPAEN.EPPYDILKRCLQCGILLPLPILNQHEVKCRQLAFSRES------r........
A0A091GUJ1_BUCRH/249-286             .........l-STSPQALED.TQSFDTLLTCAHCNILLPLPTLQKHEVR----------------.........
H9KX91_CALJA/79-126                  ..........KPRTTSPIED.EAAYDILKRCSQCGILLPLPILNQHQEKCCWLASSKGK------.........
XAF1_BOVIN/248-297                   ........kl--RASSPVED.ETAYDILRRCSQCDILLPLPTLNHHQEKCRRLASSKGKQV----.........
Z4YN17_MOUSE/127-168                 .........q-QRADLPTGD.ETAYDTLQNCCQCRILLPLPILNEHQVLC---------------spc......
W5NRX9_SHEEP/248-300                 ........kl--RASSPVED.ETAYDILRRCSQCGILLPLPTLKHHQEKCRRLASSKGNNAR---gf.......
A0A140T8C1_BOVIN/248-297             ........kl--RASSPVED.ETAYDILRRCSQCDILLPLPTLNHHQEKCRRLASSKGKQV----.........
A0A091CQG1_FUKDA/218-272             ..........KSRTASPTENeEAAYDILRRCSQCGILLPLPTLMQHQVKCKWLASSKGEQVRKAS.........
U3IES3_ANAPL/106-143                 .........l-STSPQALKD.AWSYDLLVTCAHCNVILPLPTLQKHEVR----------------.........
U3KKM7_FICAL/12-47                   .........g-STSPQALRD.TQSFDMLVTCDYCNILLPLPTLQKR-------------------e........
I3MGS8_ICTTR/229-282                 ..........KPRTAFPTED.EAAYDILRRCSQCGILLPLPTLCQHQEKCLRLASWKGKQVRKSS.........
A0A1S3W911_ERIEU/239-287             ......gyqp--------KD.EAAYNILKRCSQCGILLPLPTLNQHQGKCRLLASTKRN------asekf....
M0R7W3_RAT/127-174                   .........q-QRTALPKGE.ETAYDILRKCRQCRILLPLPILNEHQEKCLRLAQQK--------kl.......
A0A286XMZ9_CAVPO/125-173             .......gsg---AASPAEN.EPPYDILKRCLQCGILLPLPILNQHEVKCRQLAFSRES------r........
A0A1A6GU52_NEOLE/257-305             .........q-QRAALPTAD.EAAYDILRRCXQCGILLPLPVLNQHQEKCLRLAHQKK-------nt.......
G1P611_MYOLU/245-297                 ........pe--HQPWVADD.-PAYDILRRCPQCDILLPLPTLNQHQEKCWWLASWRGKQGRNSS.........
A0A093FT15_GAVST/242-295             .........l-STSLQALED.TQSFDMLETCAHCNILLPLPTLWKHEIKCLRLTSLKNARMKQKS.........
H2QC14_PANTR/248-301                 ..........KPRTSSPRGD.KAAYDILRRCSQCGILLPLPILNQHQEKCWWLASSKGKQVRNFS.........
A0A2I3M658_PAPAN/229-282             ..........KPRTSSPRGA.RTAYDILRRCSQCGILLPLPILNQHQEKCRWLASSKGKQVRNFS.........
A0A2K5MKK4_CERAT/229-282             ..........KPRTSSPRGN.RTAYDILRRCSQCGILLPLPILNQHQEKCRWLASSKGKQVRNFS.........
A0A094KVR4_ANTCR/240-277             .........v-STSPQALKD.TECFDMLVTCAHCNILLPLPTFQKHEVR----------------.........
A0A091FXX9_9AVES/238-266             .........l-STSPQALED.TQSFDILVACAQCDILLPL-------------------------.........
A0A1D5Q0P0_MACMU/248-301             ..........KPRTSSPRGD.RTAYDILRRCSQCGILLPLPILNQHQEKCRWLASSKGKQVRNFS.........
A0A1U8BM14_MESAU/221-262             .........q-PRAALPKGD.ETAYDIFRKCCWCSILLPLPILNQHQ------------------gtrdci...
G1LKU7_AILME/173-226                 ..........KRRGPSAARH.EAAYDVLRRCSLCGILLPLPILNQHQERCWWLASRKGNHARNSS.........
A0A091KL13_9GRUI/229-266             .........l-SISPEALKD.TQSFDMLVTCVHCNILLPLPTLWKHEVR----------------.........
A0A093FYG1_DRYPU/253-290             .........i-PTSPQALED.IQSFDMLKTCAHCNILLPLPTLQKHEVR----------------.........
D3ZPQ3_RAT/221-268                   .........q-QRTALPKGE.ETAYDILRKCRQCRILLPLPILNEHQEKCLRLAQQK--------kl.......
A0A1U8DML0_ALLSI/270-323             ......dpvl----PQALED.TGNYDILVTCARCNILLPLPTLKKHEIKCLHSASLQNVRRKSKS.........
A0A099YXX8_TINGU/207-260             .........l-STSAQALKD.TLCYDMMVACAHCNTFLPLSTLRKHEIKCLHLTTLQNTKMKPKS.........
W5NRX7_SHEEP/248-296                 ........kl--RASSPVED.ETAYDILRRCSQCGILLPLPTLKHHQEKCRRLASSKGNK-----.........
A0A151N5M2_ALLMI/246-299             ......dpvl----PQALED.TGNYDILVTCARCNILLPLPTLKKHEIKCLRSASLQNVRRKSKS.........
A0A091Q0U2_LEPDC/245-282             .........l-STSPQALTD.IQSFDTLVTCAHCNILLPFPTLQKHEVR----------------.........
W5JXN4_ASTMX/212-247                 .......gdl----------.----DQIRTCPNCHLALPLQTLQWHEEKCKIFESLK--------l........
A0A093FNH5_TYTAL/225-262             .........l-STSPQALKD.TQSFDTLVTCAHCNILLPLPTLWKHEVR----------------.........
A0A2K5JFV4_COLAP/248-301             .........k-PRTSSLRGD.RTAYDILRRCSQCGILLPLPILNQHQEKCRWLASSKGKQVRNFS.........
A0A1S3EX16_DIPOR/227-267             ........kl--RAASPTEE.QSAYDVLRRCSECAILLPLPTLNKHQA-----------------sayp.....
A0A091J2R3_CALAN/215-251             .........l-STSPEALKD.SQSFDMLVTCTHCNILLPLPALQKHEV-----------------.........
A0A091NZ95_HALAL/236-273             .........l-STSPQALKD.TQSFDVMVTCAHCNILLPLPTLQKHEVR----------------.........
A0A0A0A8W6_CHAVO/244-297             .........l-STSPQDLKD.TQSFDVLVTCAHCNILLPLPTLRKHEIKCLRLTSLKNARMKQKS.........
A0A091QFQ4_MERNU/179-216             .........l-STSSQALKD.TQSFDMLVTCAHCNILLPLPTLQKHEVR----------------.........
A0A091VP79_NIPNI/241-278             .........l-PTSPQALKD.TQSFDMLVTCAHCNILLPLPTLQKHEVR----------------.........
A0A093QNA9_PHACA/236-273             .........l-STLPQALKD.TQSFDMLVACDHCNILLPLPTLQKHEVR----------------.........
A0A2I3RXU7_PANTR/229-282             ..........KPRTSSPRGD.KAAYDILRRCSQCGILLPLPILNQHQEKCWWLASSKGKQVRNFS.........
A0A093NH94_PYGAD/231-268             .........l-STSPQALKD.TQSFDMLVTCAHCNILLPLPTLQKHEVR----------------.........
A0A093K1G3_STRCA/239-276             .........l-SKSPQALKD.TLSYDMMVTCAHCNILLPLPTLRKHEVR----------------.........
XAF1_MOUSE/222-271                   .........q-QRADLPTGD.ETAYDTLQNCCQCRILLPLPILNEHQEKCQRLAHQKK-------lqw......
A0A2I3HQ89_NOMLE/248-301             ..........KPRTSSPRGD.KAAYDILRRCSQCGILLPLPILNQHQEKCRWLASSKGKQVRNF-t........
G1SR91_RABIT/227-280                 .........e-SRATPTSAG.EVAYDILRRCPQCGILLPLPTLIHHQERCQRLASLRGGQVRTS-r........
F6S8R0_HORSE/248-301                 ........ka--RITSPIED.EAAYDILRRCSQCGILLPLPTLNQHQEKCLRLASSKGKQVRNSS.........
A0A094LE93_9AVES/238-275             .........l-STSPQALED.TQSFDMLVTCAYCNILLPLPTLRKHEVR----------------.........
M7BV66_CHEMY/170-208                 .......pvl----PKALED.PMTYDVLVTCSQCNILLPGPTLRKHEE-----------------ltv......
A0A087R078_APTFO/239-276             .........l-STSPQALKD.TQSFDMLVTCAHCNILLPLPTLQKHEVR----------------.........
A0A091MB15_CATAU/240-277             .........l-STSPQALKD.TQSFDMLVTCAHCNILLPLPTFQKHEVR----------------.........
H2NSG1_PONAB/247-300                 ..........KPRTSSPRGD.KAAYDILRRCSQCGILLPLPILNQHQEKCRWLASSKGKQVRNFS.........
S7MGX6_MYOBR/232-276                 .........p-EHQPWVVDD.-PAYDILRRCPQCDILLPLPTLNQHQVPASALS-----------spg......
G5B914_HETGA/240-293                 ..........KSRTASPTGN.KTAYDILRKCSQCGILLPLPTLMQHQVKCRWLASSKGEQVRKSS.........
L9KET4_TUPCH/201-254                 .........n-PWARSPTED.EAAYNILRRCSQCGILLPLPTLTQHQEKCQRLASSKAKQVKNLS.........
K7G1T1_PELSI/238-291                 ..aftsvldp--------ED.SMTYDVLAACSQCNILLPGPTLRKHETKCLRLASLQSIRRRPKS.........
A0A091SV66_9AVES/236-273             .......lct---PPQAFKD.TQSFDMLVTCAHCNILLPLPTLRKHEVR----------------.........
A0A2K5JFL8_COLAP/229-282             .........k-PRTSSLRGD.RTAYDILRRCSQCGILLPLPILNQHQEKCRWLASSKGKQVRNFS.........
A0A2I2Y2M5_GORGO/248-301             ..........KPRTSSPRGD.KAAYDILRTCSQCGILLPLPILNQHQEKCRWLASSKGKQVRNFS.........
F1MQJ9_BOVIN/248-299                 ........kl--RASSPVED.ETAYDILRRCSQCDILLPLPTLNHHQ-RCWFAQELQ--------lnqeekr..
G1LKU4_AILME/187-232                 ..........KRRGPSAARH.EAAYDVLRRCSLCGILLPLPILNQHQV-----------------pslcslltq
G3R991_GORGO/229-282                 ..........KPRTSSPRGD.KAAYDILRTCSQCGILLPLPILNQHQEKCRWLASSKGKQVRNFS.........
XAF1_HUMAN/248-301                   ..........KPRTSSPRGD.KAAYDILRRCSQCGILLPLPILNQHQEKCRWLASSKGKQVRNFS.........
#=GR XAF1_HUMAN/248-301        SS    ..........XXXS-S----.-S-TTTSEE-TTT--EE-STTHHHHHHHHHHHHHH---S-----.........
A0A1U7QKD2_MESAU/221-268             .........q-PRAALPKGD.ETAYDIFRKCCWCSILLPLPILNQHQEKCLKLAHRENK------.........
A0A093SS05_9PASS/232-285             ..........CSTSPQALKD.TQSFDMLVTCDHCDILLPLPTLRKHEIKCLHWTTLQNARMKQKS.........
M3ZJD0_XIPMA/225-268                 .rglwvnddq----------.----DQISTCPHCHLALPVPTLKWHEAKCRVH------------vvlkdre..
J9PBD0_CANLF/178-230                 .......dpr---LTFPAED.EAAYSTLGGCSCCGILLPQPILSQHQERCWWLASSRGTH-----rtgs.....
A0A096P2L4_PAPAN/248-301             ..........KPRTSSPRGA.RTAYDILRRCSQCGILLPLPILNQHQEKCRWLASSKGKQVRNFS.........
A0A091JF57_EGRGA/234-271             .........l-STSPQALKD.TQSFDMLVTCAHCNILLPLPTLRKHEVR----------------.........
A0A087Y2Z9_POEFO/221-265             rqgpwvsgdq----------.----DQISTCPHCHLALPLPTLKWHEAKCRV-------------nvvlkare.
A0A2I3GU08_NOMLE/229-282             ..........KPRTSSPRGD.KAAYDILRRCSQCGILLPLPILNQHQEKCRWLASSKGKQVRNF-t........
A0A2I0LYE5_COLLI/263-315             .........l-STPPQALKD.TQSFDMLVACAHCNILLPLPTLQKHEIKCLHLTSLKNAGMKKK-.........
A0A1S3EZR1_DIPOR/227-280             ........kl--RAASPTEE.QSAYDVLRRCSECAILLPLPTLNKHQVKCQHLASLREKQVKNQ-l........
A0A2K5MKJ5_CERAT/248-301             ..........KPRTSSPRGN.RTAYDILRRCSQCGILLPLPILNQHQEKCRWLASSKGKQVRNFS.........
A0A1L1RRJ2_CHICK/236-289             .........l-STSSQVLKD.TQSYDMLVTCAHCNTPLPLSALQKHEIKCLHFISLKNVKMNQK-p........
A0A1U7UPM4_TARSY/247-300             .........n-PRTTSLIED.EAAYDILRRCSQCGILLPLPTLNRHQEKCWWLASSKGKQVRNSS.........
F7AC39_MACMU/229-282                 ..........KPRTSSPRGD.RTAYDILRRCSQCGILLPLPILNQHQEKCRWLASSKGKQVRNFS.........
A0A0D9RIW3_CHLSB/248-301             ..........KPRTSSPRGD.RAAYDILRRCSQCGILLPLPILNQHQEKCRWLASSKGKQVRN--fi.......
A0A0A0A8N6_CHAVO/255-308             .........l-STSPQDLKD.TQSFDVLVTCAHCNILLPLPTLRKHEIKCLRLTSLKNARMKQKS.........
G7PTE5_MACFA/249-302                 ..........KPRTSSPRGD.RTAYDILRRCSQCGILLPLPILNQHQEKCRWLASSKGKQVRNFS.........
G3VUF7_SARHA/212-258                 .......lss--RATQIKK-.-EEYDVLESCSFCHILLPLPVLKQHEEKCQLLASQQ--------wk.......
#=GC SS_cons                         ..........XXXS-S----.-S-TTTSEE-TTT--EE-STTHHHHHHHHHHHHHH---S-----.........
#=GC seq_cons                        ...........spsspshcD.psuYDlLppCupCsILLPLPTLppHp.KChhhsp.p.................
//
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