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Database: Pfam
Entry: ptaRNA1_toxin
LinkDB: ptaRNA1_toxin
Original site: ptaRNA1_toxin 
#=GF ID   ptaRNA1_toxin
#=GF AC   PF12703.7
#=GF DE   Toxin of toxin-antitoxin type 1 system
#=GF PI   plasmid_Toxin; PtaRNA1-toxin;
#=GF AU   Gardner P;0000-0002-7808-1213
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   Gardner P [1])
#=GF GA   19.40 19.00;
#=GF TC   20.60 19.10;
#=GF NC   18.70 16.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   PtaRNA1
#=GF RN   [1]
#=GF RM   20220307
#=GF RT   A novel family of plasmid-transferred anti-sense ncRNAs.
#=GF RA   Findeiss S, Schmidtke C, Stadler PF, Bonas U;
#=GF RL   RNA Biol. 2010;7:120-124.
#=GF DR   INTERPRO; IPR024640;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family is the toxin of a type 1 toxin-antitoxin system
#=GF CC   which is found in a relatively widespread range of bacterial
#=GF CC   species. The species distribution suggests frequent horizontal
#=GF CC   gene transfer.  In a type 1 system, as characterised for the
#=GF CC   plasmid-encoded E coli hok/sok system, the toxin-encoding stable
#=GF CC   mRNA encodes a protein which rapidly leads to cell death unless
#=GF CC   the translation is suppressed by a short-lived small RNA. The
#=GF CC   plasmid-encoded module prevents the growth of plasmid-free
#=GF CC   offspring, thus ensuring the persistence of the plasmid in the
#=GF CC   population. Plasmid-free cells arising after cell-division will
#=GF CC   be killed because the stable mRNA toxin is present while the
#=GF CC   comparably unstable anti-toxin is rapidly degraded. Where the
#=GF CC   system is transcribed chromosomally, the mechanism is poorly
#=GF CC   understood [1].
#=GF SQ   21
#=GS B4EEA0_BURCJ/1-73         AC B4EEA0.1
#=GS A1U1D1_MARHV/1-73         AC A1U1D1.1
#=GS A0A2G1UPA0_9ALTE/1-73     AC A0A2G1UPA0.1
#=GS A0A0K1XD00_9GAMM/1-73     AC A0A0K1XD00.1
#=GS A0A1I2GJK7_9BURK/1-73     AC A0A1I2GJK7.1
#=GS A0A1M5SD01_9PSED/1-73     AC A0A1M5SD01.1
#=GS Q63PW1_BURPS/1-73         AC Q63PW1.1
#=GS Q0ADV5_NITEC/1-73         AC Q0ADV5.1
#=GS A0A103EHI8_9BURK/1-73     AC A0A103EHI8.1
#=GS A0A1V4A5C8_9ACTN/256-308  AC A0A1V4A5C8.1
#=GS A0A231HKU6_9BURK/1-73     AC A0A231HKU6.1
#=GS A0A256CTH6_9GAMM/1-73     AC A0A256CTH6.1
#=GS A0A220ST46_9GAMM/1-73     AC A0A220ST46.1
#=GS A0A242P799_9GAMM/1-73     AC A0A242P799.1
#=GS D2UDH0_XANAP/1-73         AC D2UDH0.1
#=GS U1ZUI8_9BURK/1-73         AC U1ZUI8.1
#=GS A0A1G6CCN9_9GAMM/1-73     AC A0A1G6CCN9.1
#=GS A0A261TM66_9BORD/1-73     AC A0A261TM66.1
#=GS W8WY27_CASDE/1-75         AC W8WY27.1
#=GS F6ENA2_HOYSD/149-217      AC F6ENA2.1
#=GS A1W8W7_ACISJ/1-73         AC A1W8W7.1
B4EEA0_BURCJ/1-73                    ......MATMHDTEA..REVIHHTAMRLAALEFIDRHAAKDLSQM.AEAVANLFVVVFYQAETGRATRSDFREAMTAVRQAL...................
A1U1D1_MARHV/1-73                    ......MTATHNIEV..QQAIHQAATKLSALKFIDQETARQISPV.AEAVANMFTILYYQAETGRATQEDFQEALATIRQAT...................
A0A2G1UPA0_9ALTE/1-73                ......MTTTHNIEV..QQAIHQAATKLAALEFIDQETARQISPV.AEAVANMFTILYYQAETGRATPEDFQEALDTIRQV-t..................
A0A0K1XD00_9GAMM/1-73                ......MTTQHIIEP..GQAVHQAAAILSSLEYINQAEARSLGPL.AEAVANAFMVVYYQAETGRATQADFQEAMNALRQA-c..................
A0A1I2GJK7_9BURK/1-73                ......MATLNPTNA..TQAVHHAAAQLASLDWIDQDAARQLRPL.AEAVANAFMVVFYQAETGQATPADFRDALDAVRQSL...................
A0A1M5SD01_9PSED/1-73                ......MATVNFNNV..TQAVHHAAVQLAALDWIDQEEAQQLGPM.AEAVANAFMVVFYQAETGQATPADFREALDAVRQSL...................
Q63PW1_BURPS/1-73                    ......MATMHDTEA..REVIHHTAMQLAALEFIDPHAAKDLSEM.TEAMVNLFVVVFYQAETGRATRSDFREAMTAVRQAL...................
Q0ADV5_NITEC/1-73                    ......MTTQHIIEP..GQAVHQAAAILSSLEYINQAEARSLGPL.AEAVANAFMVVYYQAETGRATQADFQEAMNALRQA-c..................
A0A103EHI8_9BURK/1-73                ......MATMHDTEA..REVIHLTAMKLAALEFIDPLTAKDLSEM.AEAVANLFVVVFYQAETGRATRSDFREARTAVRQAL...................
A0A1V4A5C8_9ACTN/256-308             ..tall----APPDA..STVVFQARVGLTALELVPDHTARPVVPL.REAIANM-----------------------------asrdayaar..........
A0A231HKU6_9BURK/1-73                ......MTTQHIIEP..GQAVHQAAAILSSLEYINQAEARSLGPL.AEAVANAFMVVYYQAETGRATQADFQEAMNALRQA-c..................
A0A256CTH6_9GAMM/1-73                ......MTTQHIIEP..GQAVHQAAAILSSLEYINQAEARSLGPL.AEAVANAFMVVYYQAETGRATQADFQEAMNALRQA-c..................
A0A220ST46_9GAMM/1-73                ......MTTQHLIEP..GQVVHQAAAIIASLEYIDQGAAQRLGPL.AEVVTNAFMVVYYQAETGRATRNDFCEALEAIRRSL...................
A0A242P799_9GAMM/1-73                ......MTTQHIIEP..GQAVHQAAAILSSLEYINQAEARSLGPL.AEAVANAFMVVYYQAETGRATQADFQEAMNALRQA-c..................
D2UDH0_XANAP/1-73                    ......MATTHDIEA..RQVIHHAATQLADLDFMDQRTAQELSTM.AEAVANLFMVVFYQAETGRATHGDFSEAMAAVRQTL...................
U1ZUI8_9BURK/1-73                    ......MTTQHLIEP..DQVVHQAAAILASLEYIDQGAAQRLGPL.AEAVTNAFMVVYYQAETGRATRNDFCEALEAIRRSL...................
A0A1G6CCN9_9GAMM/1-73                ......MTTQHIIEP..GQAVHQAAAILSSLEYINQAEARSLGPL.AEAVANAFMVVYYQAETGRATQADFQEAMNALRQA-c..................
A0A261TM66_9BORD/1-73                ......MATIHPNEF..SQAVQHAATELNAIGWLGQDAARELGPL.AEATANLFMVLFYQAETGLATRGDFSQARAQIQ---hvl................
W8WY27_CASDE/1-75                    ......MATLNPTNAtaTQAVHHAAAQLAALDWIDQEAARQLSPM.AEAVANMFMVLYYQAETGLASRDDFREALDAVRQSL...................
F6ENA2_HOYSD/149-217                 gdaelm--------L..REATREAATALAKLEFIDTSGGQDVRPMiVEALADLSAVRYPD----------------------sippraarvfdaaneidai
A1W8W7_ACISJ/1-73                    ......MATLNPTNA..TQAVHHAAVQLAALDWLDQDAARQLGPL.AEAVANAFMVVFYQAETGQATPADFREALDAVRQSL...................
#=GC seq_cons                        ......MsT.H.hEs..sQAVHpAAstLuuLEaIDQtsARpLuPl.AEAVANhFMVVaYQAETGRATpuDFpEAhsAlRQu....................
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