#=GF ID zf-NPL4
#=GF AC PF05020.19
#=GF DE NPL4 family, putative zinc binding region
#=GF AU Wood V;0000-0001-6330-7526
#=GF SE Pfam-B_13681 (release 7.6)
#=GF GA 25.00 25.00;
#=GF TC 25.00 25.10;
#=GF NC 24.90 24.50;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 11739805
#=GF RT HRD4/NPL4 is required for the proteasomal processing of
#=GF RT ubiquitinated ER proteins.
#=GF RA Bays NW, Wilhovsky SK, Goradia A, Hodgkiss-Harlow K, Hampton RY;
#=GF RL Mol Biol Cell 2001;12:4114-4128.
#=GF RN [2]
#=GF RM 11574150
#=GF RT Cloning and characterization of the gene encoding human NPL4, a
#=GF RT protein interacting with the ubiquitin fusion-degradation
#=GF RT protein (UFD1L).
#=GF RA Botta A, Tandoi C, Fini G, Calabrese G, Dallapiccola B, Novelli
#=GF RA G;
#=GF RL Gene 2001;275:39-46.
#=GF DR INTERPRO; IPR007716;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC The HRD4 gene was identical to NPL4, a gene previously
#=GF CC implicated in nuclear transport. Using a diverse set of
#=GF CC substrates and direct ubiquitination assays, analysis revealed
#=GF CC that HRD4/NPL4 is required for a poorly characterised step in
#=GF CC ER-associated degradation after ubiquitination of target
#=GF CC proteins but before their recognition by the 26S proteasome [1].
#=GF CC This region of the protein contains possibly two zinc binding
#=GF CC motifs (Bateman A pers. obs.). Npl4p physically associates with
#=GF CC Cdc48p via Ufd1p to form a Cdc48p-Ufd1p-Npl4p complex. The
#=GF CC Cdc48-Ufd1-Npl4 complex functions in the recognition of several
#=GF CC polyubiquitin-tagged proteins and facilitates their presentation
#=GF CC to the 26S proteasome for processive degradation or even more
#=GF CC specific processing.
#=GF SQ 2274
#=GS A0A8C7XDX5_9TELE/117-257 AC A0A8C7XDX5.1
#=GS A0A6P8XBK2_DROAB/111-249 AC A0A6P8XBK2.1
#=GS A0A8H4AD14_GIGMA/5-146 AC A0A8H4AD14.1
#=GS I3L829_PIG/262-402 AC I3L829.3
#=GS A0A673K1K9_9TELE/105-217 AC A0A673K1K9.1
#=GS A0A4S2MEZ2_OPIFE/111-251 AC A0A4S2MEZ2.1
#=GS A0A8H5DGW6_9HYPO/126-269 AC A0A8H5DGW6.1
#=GS A0A8C4BGA4_9TELE/121-261 AC A0A8C4BGA4.1
#=GS A0A0N0RYA4_9EURO/136-280 AC A0A0N0RYA4.1
#=GS A0A151GEA0_9HYPO/132-275 AC A0A151GEA0.1
#=GS A0A8J5ZMP4_GALPY/535-675 AC A0A8J5ZMP4.1
#=GS B0WJW8_CULQU/136-274 AC B0WJW8.1
#=GS A0A6J1MID7_BICAN/125-259 AC A0A6J1MID7.1
#=GS A0A8C7GTG6_ONCKI/14-153 AC A0A8C7GTG6.1
#=GS C9SHW0_VERA1/141-240 AC C9SHW0.1
#=GS A0A0Q9X5W2_DROWI/120-258 AC A0A0Q9X5W2.1
#=GS W9WZX6_9EURO/137-281 AC W9WZX6.1
#=GS A0A8C9LB28_PAVCR/107-247 AC A0A8C9LB28.1
#=GS A0A7L0Z6T8_9PASE/101-241 AC A0A7L0Z6T8.1
#=GS A0A8H5LZA9_9AGAR/112-255 AC A0A8H5LZA9.1
#=GS A0A8B9D3C4_ANSCY/125-265 AC A0A8B9D3C4.1
#=GS A0A6J2TJ58_DROLE/149-287 AC A0A6J2TJ58.1
#=GS A0A1B9GB28_9TREE/133-278 AC A0A1B9GB28.1
#=GS A0A0V0WJ90_9BILA/459-560 AC A0A0V0WJ90.1
#=GS G8BMS7_TETPH/118-261 AC G8BMS7.1
#=GS A0A226P7P6_COLVI/106-246 AC A0A226P7P6.1
#=GS C4JW14_UNCRE/154-298 AC C4JW14.1
#=GS A0A1D3U905_9APIC/202-241 AC A0A1D3U905.1
#=GS A0A167UYE9_9EURO/93-237 AC A0A167UYE9.1
#=GS A0A8C4T7Y5_ERPCA/107-247 AC A0A8C4T7Y5.1
#=GS A0A0L7LC42_OPEBR/145-182 AC A0A0L7LC42.1
#=GS A0A668SRG8_OREAU/103-243 AC A0A668SRG8.1
#=GS I7LTY6_TETTS/157-293 AC I7LTY6.2
#=GS A0A7L4BJK1_9CHAR/106-246 AC A0A7L4BJK1.1
#=GS A0A6P3FKM4_OCTDE/83-223 AC A0A6P3FKM4.1
#=GS A0A0V1LH96_9BILA/531-671 AC A0A0V1LH96.1
#=GS A0A8R2R3K6_BOMMO/133-267 AC A0A8R2R3K6.1
#=GS A0A2S7QKU4_9HELO/142-286 AC A0A2S7QKU4.1
#=GS A0A7L0L876_9SYLV/106-246 AC A0A7L0L876.1
#=GS A0A672KR39_SINGR/99-213 AC A0A672KR39.1
#=GS A0A7K9T1I4_9AVES/101-241 AC A0A7K9T1I4.1
#=GS A0A1B8CEX5_9PEZI/141-285 AC A0A1B8CEX5.1
#=GS A0A3Q1I6Y6_ANATE/124-264 AC A0A3Q1I6Y6.1
#=GS A0A671N8G7_9TELE/90-230 AC A0A671N8G7.1
#=GS A0A671N8C1_9TELE/91-231 AC A0A671N8C1.1
#=GS A0A8H6DVV9_COCSA/128-272 AC A0A8H6DVV9.1
#=GS A0A2G4SWB1_RHIZD/109-248 AC A0A2G4SWB1.1
#=GS A0A165MDS0_9APHY/110-255 AC A0A165MDS0.1
#=GS A0A5N6TVL3_9EURO/140-284 AC A0A5N6TVL3.1
#=GS A0A1S7HA87_9SACH/112-254 AC A0A1S7HA87.1
#=GS A0A8C3V8J3_CATUS/193-333 AC A0A8C3V8J3.1
#=GS A0A672ZZX9_9TELE/89-214 AC A0A672ZZX9.1
#=GS A0A074VXG4_9PEZI/129-273 AC A0A074VXG4.1
#=GS A0A6J0YKA2_ODOVR/105-245 AC A0A6J0YKA2.1
#=GS I3KNQ4_ORENI/121-261 AC I3KNQ4.1
#=GS A0A452H0U5_9SAUR/34-174 AC A0A452H0U5.1
#=GS A0A7K8B5Z6_9CORV/101-241 AC A0A7K8B5Z6.1
#=GS A0A8U0SEV6_MUSPF/105-245 AC A0A8U0SEV6.1
#=GS A0A8K0DFD8_9COLE/135-273 AC A0A8K0DFD8.1
#=GS A0A7K4JYH9_9AVES/106-246 AC A0A7K4JYH9.1
#=GS A0A1V6Z1A0_PENNA/136-280 AC A0A1V6Z1A0.1
#=GS A0A8C5BJZ8_GADMO/108-248 AC A0A8C5BJZ8.1
#=GS A0A1X2H773_SYNRA/108-255 AC A0A1X2H773.1
#=GS S3BYE4_OPHP1/151-295 AC S3BYE4.1
#=GS A0A653DX38_CALMS/122-260 AC A0A653DX38.1
#=GS A0A7K7W4A5_9AVES/106-246 AC A0A7K7W4A5.1
#=GS A0A3S5AQY6_9PLAT/11-87 AC A0A3S5AQY6.1
#=GS A0A8C1DTD6_CYPCA/121-261 AC A0A8C1DTD6.1
#=GS A0A0D2DIL0_9EURO/137-281 AC A0A0D2DIL0.1
#=GS A0A668SRV3_OREAU/103-243 AC A0A668SRV3.1
#=GS A0A094FUR3_9PEZI/141-285 AC A0A094FUR3.1
#=GS A0A8C2WPQ0_CYCLU/131-271 AC A0A8C2WPQ0.1
#=GS A0A093YBP3_9PEZI/141-285 AC A0A093YBP3.1
#=GS A0A1J8QZI5_9AGAM/110-253 AC A0A1J8QZI5.1
#=GS A0A395SSI5_9HYPO/125-268 AC A0A395SSI5.1
#=GS A0A2T4C9I5_TRILO/128-271 AC A0A2T4C9I5.1
#=GS A0A1Q5T810_9EURO/163-307 AC A0A1Q5T810.1
#=GS A0A3Q4ARA7_MOLML/92-232 AC A0A3Q4ARA7.1
#=GS A0A485NG77_LYNPA/105-245 AC A0A485NG77.1
#=GS A0A672K9G8_SINGR/59-158 AC A0A672K9G8.1
#=GS A0A8C9Q0Z2_SPEDA/100-240 AC A0A8C9Q0Z2.1
#=GS A0A653DPY5_CALMS/122-260 AC A0A653DPY5.1
#=GS A0A5J4N6U7_9TREM/113-253 AC A0A5J4N6U7.1
#=GS M4AJF3_XIPMA/127-267 AC M4AJF3.1
#=GS B4QVC0_DROSI/141-279 AC B4QVC0.1
#=GS A0A673WNM9_SALTR/88-228 AC A0A673WNM9.1
#=GS A0A6P8XQL3_DROAB/115-253 AC A0A6P8XQL3.1
#=GS A0A1Y2HF32_9FUNG/105-248 AC A0A1Y2HF32.1
#=GS A0A158NRV9_ATTCE/155-293 AC A0A158NRV9.1
#=GS A0A8U0V8D6_MUSPF/105-245 AC A0A8U0V8D6.1
#=GS A0A1B8GD24_9PEZI/141-285 AC A0A1B8GD24.2
#=GS A0A4Q4VGI3_9PEZI/139-282 AC A0A4Q4VGI3.1
#=GS A0A8C8BYC1_ONCTS/126-266 AC A0A8C8BYC1.1
#=GS V5IPA1_NEUCR/138-282 AC V5IPA1.1
#=GS A0A1L7WCN4_9HELO/141-285 AC A0A1L7WCN4.1
#=GS A0A6P8XKX2_DROAB/144-282 AC A0A6P8XKX2.1
#=GS A0A2K6NHC0_RHIRO/105-245 AC A0A2K6NHC0.1
#=GS A0A0L0BWD6_LUCCU/138-276 AC A0A0L0BWD6.1
#=GS A0A0J8TW49_COCIT/133-277 AC A0A0J8TW49.1
#=GS A0A8E0V410_9EURO/140-284 AC A0A8E0V410.1
#=GS A0A8P4KFA1_DICLA/78-218 AC A0A8P4KFA1.1
#=GS A0A4W5KZY0_9TELE/65-205 AC A0A4W5KZY0.1
#=GS A0A1X7R262_9SACH/126-269 AC A0A1X7R262.1
#=GS A0A4C1XLU4_EUMVA/57-192 AC A0A4C1XLU4.1
#=GS A0A287B880_PIG/262-408 AC A0A287B880.3
#=GS A0A0V1NSA9_9BILA/520-661 AC A0A0V1NSA9.1
#=GS A0A673A0L3_9TELE/110-235 AC A0A673A0L3.1
#=GS G0VBE5_NAUCC/110-253 AC G0VBE5.1
#=GS A0A6P5LL36_PHACI/231-371 AC A0A6P5LL36.1
#=GS A0A8H7V820_9FUNG/101-247 AC A0A8H7V820.1
#=GS A0A8H5H6K7_9AGAR/137-280 AC A0A8H5H6K7.1
#=GS A0A026W133_OOCBI/52-190 AC A0A026W133.1
#=GS A0A851WRG1_CORMO/106-246 AC A0A851WRG1.1
#=GS L5KN67_PTEAL/62-202 AC L5KN67.1
#=GS A0A8J5ANT1_9DIPT/113-251 AC A0A8J5ANT1.1
#=GS I3MYM8_ICTTR/100-240 AC I3MYM8.2
#=GS A0A8R2QZ89_BOMMO/165-299 AC A0A8R2QZ89.1
#=GS A0A670YCX1_PSETE/106-246 AC A0A670YCX1.1
#=GS A0A210QSU2_MIZYE/124-264 AC A0A210QSU2.1
#=GS A0A059JG83_TRIIM/145-289 AC A0A059JG83.1
#=GS A0A3N4KHW4_9PEZI/137-280 AC A0A3N4KHW4.1
#=GS A0A5C3LNU7_9AGAR/112-255 AC A0A5C3LNU7.1
#=GS A0A8H6NU13_9PEZI/138-281 AC A0A8H6NU13.1
#=GS D8LZE8_BLAHO/48-150 AC D8LZE8.1
#=GS A0A8H4AD42_GIGMA/1-110 AC A0A8H4AD42.1
#=GS M7PMM1_PNEMU/101-240 AC M7PMM1.1
#=GS A0A7K6W2V9_STECA/104-244 AC A0A7K6W2V9.1
#=GS A0A674JR00_TERCA/124-264 AC A0A674JR00.1
#=GS A0A672K4D8_SINGR/121-261 AC A0A672K4D8.1
#=GS A0A8B9NJ27_9AVES/107-247 AC A0A8B9NJ27.1
#=GS A0A433PLX4_9FUNG/234-263 AC A0A433PLX4.1
#=GS A0A8H7DWZ6_PLEOS/113-257 AC A0A8H7DWZ6.1
#=GS A0A7K7Z435_THRLU/101-241 AC A0A7K7Z435.1
#=GS A0A836JLL7_9HYME/21-159 AC A0A836JLL7.1
#=GS A0A0D1ZRQ4_9EURO/139-283 AC A0A0D1ZRQ4.1
#=GS A0A1V8UXT0_9PEZI/128-272 AC A0A1V8UXT0.1
#=GS X0D3W8_FUSOX/126-269 AC X0D3W8.1
#=GS A0A2T9ZGA8_9FUNG/124-272 AC A0A2T9ZGA8.1
#=GS A0A7K4UD77_9SYLV/101-241 AC A0A7K4UD77.1
#=GS A0A5F7ZRG6_MACMU/105-245 AC A0A5F7ZRG6.1
#=GS A0A8C2WP38_CYCLU/138-278 AC A0A8C2WP38.1
#=GS W6UKU0_ECHGR/102-241 AC W6UKU0.1
#=GS A5KB05_PLAVS/210-250 AC A5KB05.1
#=GS A0A5N6FVD2_PETAA/140-284 AC A0A5N6FVD2.1
#=GS A0A673UPK3_SURSU/100-240 AC A0A673UPK3.1
#=GS A0A813R5V7_9BILA/115-258 AC A0A813R5V7.1
#=GS A0A674HKY5_TAEGU/106-246 AC A0A674HKY5.1
#=GS A0A1C7N4N0_9FUNG/101-247 AC A0A1C7N4N0.1
#=GS E3RPK7_PYRTT/128-272 AC E3RPK7.1
#=GS A0A7M7TGZ4_STRPU/119-259 AC A0A7M7TGZ4.1
#=GS A0A2A2LF34_9BILA/9-149 AC A0A2A2LF34.1
#=GS A0A8B9PHD7_APTOW/110-250 AC A0A8B9PHD7.1
#=GS A0A7L1UJV5_PHANI/106-246 AC A0A7L1UJV5.1
#=GS A0A0V1MYB7_9BILA/538-679 AC A0A0V1MYB7.1
#=GS A0A672KS23_SINGR/89-160 AC A0A672KS23.1
#=GS A0A899FZL0_9ASCO/101-240 AC A0A899FZL0.1
#=GS A7SZA1_NEMVE/29-169 AC A7SZA1.1
#=GS A0A3Q0JJ87_DIACI/129-170 AC A0A3Q0JJ87.1
#=GS A0A384J5U9_BOTFB/142-286 AC A0A384J5U9.1
#=GS A0A6P7KJQ0_9TELE/120-260 AC A0A6P7KJQ0.1
#=GS A0A7L1YIA8_9PASS/101-241 AC A0A7L1YIA8.1
#=GS A0A7L0MSQ3_9PSIT/101-241 AC A0A7L0MSQ3.1
#=GS S8G259_FOMPI/110-255 AC S8G259.1
#=GS A0A6I9YWF7_9SAUR/106-246 AC A0A6I9YWF7.1
#=GS A0A0V1ABR0_9BILA/534-675 AC A0A0V1ABR0.1
#=GS A0A671NG92_9TELE/34-174 AC A0A671NG92.1
#=GS N1RJG2_FUSC4/126-269 AC N1RJG2.1
#=GS A0A8C0H2K6_CHEAB/34-174 AC A0A8C0H2K6.1
#=GS A0A4W4DSS7_ELEEL/88-228 AC A0A4W4DSS7.1
#=GS A0A7K6B7J7_UPUEP/101-241 AC A0A7K6B7J7.1
#=GS A0A091MNC2_9PASS/101-241 AC A0A091MNC2.1
#=GS A0A1R1PK16_ZANCU/2-57 AC A0A1R1PK16.1
#=GS A0A0V0TQS1_9BILA/109-249 AC A0A0V0TQS1.1
#=GS A0A6G0USL9_9BILA/9-150 AC A0A6G0USL9.1
#=GS A0A179IJM1_CORDF/127-271 AC A0A179IJM1.1
#=GS A0A0J0XPA1_9TREE/129-272 AC A0A0J0XPA1.1
#=GS A0A2N5TQU0_9BASI/146-291 AC A0A2N5TQU0.1
#=GS A0A1J9S3I7_9PEZI/129-273 AC A0A1J9S3I7.1
#=GS A0A8J0TSD1_XENLA/104-244 AC A0A8J0TSD1.1
#=GS A0A7L2YBJ5_JACJC/101-241 AC A0A7L2YBJ5.1
#=GS A0A3M7N1S1_9EURO/138-282 AC A0A3M7N1S1.1
#=GS A0A7L1GKU8_9PICI/106-246 AC A0A7L1GKU8.1
#=GS NPL4_YEAST/113-256 AC P33755.1
#=GS Q8SRJ9_ENCCU/69-199 AC Q8SRJ9.1
#=GS A0A3M9YKS3_9PEZI/141-285 AC A0A3M9YKS3.1
#=GS A0A1Y2BD60_9FUNG/90-236 AC A0A1Y2BD60.1
#=GS A0A2X0MBZ1_9BASI/188-301 AC A0A2X0MBZ1.1
#=GS A0A2T9YBM1_9FUNG/96-245 AC A0A2T9YBM1.1
#=GS B4GF67_DROPE/147-221 AC B4GF67.1
#=GS A0A0V0UTC0_9BILA/534-675 AC A0A0V0UTC0.1
#=GS A0A662Z230_ACIRT/125-265 AC A0A662Z230.1
#=GS A0A3M0WCW1_9EURO/138-282 AC A0A3M0WCW1.1
#=GS A0A850W7M8_FREMA/101-241 AC A0A850W7M8.1
#=GS A0A667ZIS4_9TELE/93-233 AC A0A667ZIS4.1
#=GS A0A512UMQ1_9ASCO/121-264 AC A0A512UMQ1.1
#=GS A0A834PDB3_VESPE/133-271 AC A0A834PDB3.1
#=GS A0A4V3UQ21_9EURO/138-282 AC A0A4V3UQ21.1
#=GS M3JZF2_CANMX/120-260 AC M3JZF2.1
#=GS A0A5C3PTD3_9APHY/109-254 AC A0A5C3PTD3.1
#=GS A0A8C6R4J2_NANGA/105-245 AC A0A8C6R4J2.1
#=GS A0A433SYK5_ELYCH/111-251 AC A0A433SYK5.1
#=GS A0A8B9TZE8_9AVES/33-173 AC A0A8B9TZE8.1
#=GS A0A1Y2WID0_9PEZI/138-281 AC A0A1Y2WID0.1
#=GS A0A161VQY3_9PEZI/135-278 AC A0A161VQY3.1
#=GS A0A7R8CII3_LEPSM/151-290 AC A0A7R8CII3.1
#=GS A0A0G4MLB0_9PEZI/141-285 AC A0A0G4MLB0.1
#=GS A0A0V1CJ64_TRIBR/534-675 AC A0A0V1CJ64.1
#=GS A0A8H6TMW4_9AGAR/107-250 AC A0A8H6TMW4.1
#=GS A0A5N3X137_MUNRE/82-222 AC A0A5N3X137.1
#=GS A0A8B9YS20_BOSMU/105-245 AC A0A8B9YS20.1
#=GS A0A6P5DHY6_BOSIN/105-245 AC A0A6P5DHY6.1
#=GS A0A072PDI5_9EURO/140-284 AC A0A072PDI5.1
#=GS A0A3P8HIM7_TRIRE/1-63 AC A0A3P8HIM7.1
#=GS A0A168IMM0_CORDF/127-271 AC A0A168IMM0.1
#=GS A0A851SHU4_CERFA/106-246 AC A0A851SHU4.1
#=GS A0A2K6D7Q0_MACNE/78-218 AC A0A2K6D7Q0.1
#=GS A0A4Z2DQ07_SCHJA/115-255 AC A0A4Z2DQ07.1
#=GS A0A6J0BSC2_NEOLC/130-268 AC A0A6J0BSC2.1
#=GS A0A6P8YRY7_THRPL/133-271 AC A0A6P8YRY7.1
#=GS A0A2K5YRU2_MANLE/100-240 AC A0A2K5YRU2.1
#=GS A0A151IS93_9HYME/309-447 AC A0A151IS93.1
#=GS A0A814CID2_ADIRI/104-245 AC A0A814CID2.1
#=GS A0A420S711_FUSOX/126-269 AC A0A420S711.1
#=GS A0A0Q9X1K3_DROMO/115-253 AC A0A0Q9X1K3.1
#=GS A0A1I7SWB7_BURXY/12-152 AC A0A1I7SWB7.1
#=GS A0A7L1UVT5_SITEU/101-241 AC A0A7L1UVT5.1
#=GS F4WXE3_ACREC/140-278 AC F4WXE3.1
#=GS A0A821QH91_9NEOP/126-260 AC A0A821QH91.1
#=GS A0A0R3T8T9_RODNA/99-238 AC A0A0R3T8T9.1
#=GS A0A1G4BC22_9PEZI/138-282 AC A0A1G4BC22.1
#=GS A0A507DAZ1_9FUNG/107-253 AC A0A507DAZ1.1
#=GS M9LPD7_PSEA3/133-276 AC M9LPD7.1
#=GS A0A6V7U8M3_9BILA/1-86 AC A0A6V7U8M3.1
#=GS A0A177CMP8_9PLEO/128-272 AC A0A177CMP8.1
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A0A0D2DQ00_9EURO/137-281 ..........................................................................................VKQSPLDDRLDKRD..GKISRPR.DA.........K.M............CRH...G.P..K.GMC......D.YCQ.P...L.....E...............PYDK.KYL..D..ERK........IKHLSFHSYLRKINLA...T...N...KP.......E.................L...K..S............SYM.......PP.L...TEPYYR..VKKE..CPSG.HPPWP...EGICTKCQ.PS.AITLQP.....QEFRMVD......HVEFSSADMVDRLIDFWRKSG...................................
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A0A0F7ZLQ6_9HYPO/129-272 ..........................................................................................VKQSALDDRLDKLD..GKIPRGR.D-.........R.M............CRH...G.P..K.GMC......D.YCQ.P...M.....D...............PFDI.GYL..A..EKK........IKYTSFHSHLRKVNAS...T...N...KP.......E.................L...G..S............SYI.......PP.L...VEPFYR..VRRD..CPTG.HPPWP...EGVCTKCQ.PS.AITLNP.....QSFRMVD......HVEFASPAIVDTFIDPWRKTG...................................
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A0A7K5JL87_9TYRA/106-246 .........................................................................................v-VEDEIDQYLIKQD..GKIYRNR.DQ.........Q.L............CRH...G.P..L.GKC......V.HCV.P...L.....E...............PFDE.DYL..N..HLEp......pVKHMSFHAYIRKLTGG...A...D...K-.......-.................-...-..-............GKF.......VA.L...ENISCK..IKSG..CEG-.HPPWP...EGICTKCQ.PS.AITLNR.....QKYRHVD......NIMFENHTIADRFLDFWRKTG...................................
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A0A3P7JQ72_STRVU/9-63 ........................................................................................ek--LDEVDLILAAED..GQIKRSR.DP.........K.M............CHH...N.A..R.QKC......A.HCL.P...I.....D...............----.---..-..---........----------------...-...-...--.......-.................-...-..-............---.......--.-...------..----..----.-----...--------.--.------.....-------......---------------------vsiflyhpsrssil.....................
A0A218ULE4_9PASE/106-246 .........................................................................................v-VEDEIDQYLIKQD..GKIYRNR.DQ.........Q.L............CRH...G.P..L.GKC......V.HCV.P...L.....E...............PFDE.DYL..N..HLEp......pVKHMSFHAYIRKLTGG...A...D...K-.......-.................-...-..-............GKF.......VA.L...ENISCK..IKSG..CEG-.HPPWP...EGICTKCQ.PS.AITLNR.....QKYRHVD......NIMFENHTIADRFLDFWRKTG...................................
A0A8E2DJ27_9APHY/108-252 ..........................................................................................VQEDPVDTYWRSQD..GKLPRGR.DS.........R.F............CKH...G.A..N.AMC......D.YCM.P...L.....E...............PYDI.EYH..T..KHN........IKHLSYHAYLRKLLPK...N...T...-P.......T.................T...S..S............TLL.......PP.L...DPLSYK..VKVP..CPSGsHPPWP...AAICSGCQ.PS.AITLQS.....QPFRMVD......HLEIASTDVIDRFLQAWRKTG...................................
A0A4Q1BDY7_TREME/135-278 .........................................................................................v-VEPEIDQYWEKQS..GKIERKF.DP.........Q.F............CRH...G.E..K.GMC......D.YCM.P...L.....E...............PYDM.KYQ..A..ENQ........IKHLSYHSYLKKLLSS...R...P...P-.......-.................N...S..T............SDI.......PP.L...TPLSLS..VQTP..CPTGsHAPFP...AGICSTCQ.PS.ALTLSS.....QTFRMVD......HVEFSTPTLIDELLFAWRKTG...................................
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NPL4_CANGA/114-257 ........................................................................................ad--ELEVDKELEKLD..GLIPRQK.T-.........K.L............CKH...G.D..R.GMC......E.YCS.P...L.....P...............PWDA.NYA..N..ENN........IKHISFHAYLKKLNES...T...N...KR.......E.................S...G..S............SYI.......AP.L...SQPNFK..INKH..CTNG.HEPWP...KGICSKCQ.PS.AITLQQ.....QEFRMVD......HVEFQSSELINQFIEFWRASG...................................
A0A8C9ZUC1_SANLU/106-245 ..........................................................................................VQEDEIDQYLTKQD..GKIYRNK.DP.........Q.L............CHH...G.S..L.GKC......V.HCV.P...L.....E...............VREF.IFV..F..LIS.......yRDHMSFHAYLRKLTGG...A...D...K-.......-.................-...-..-............GKF.......AA.L...ENISCK..IKSG..CEG-.HPPWP...EGICTKCQ.PS.AITLNR.....QKYRHVD......NIMFENHTIADRFLDFWRKTG...................................
A0A2I1BWF0_ASPN1/140-284 ..........................................................................................VQQSQLDDMLDKKD..GKIYRPH.DP.........K.M............CKH...G.P..K.GMC......D.YCM.P...L.....E...............PYDP.KYL..A..EKK........IKHLSFHSYMRKVNAT...T...N...KT.......E.................L...K..S............SFM.......PP.L...NEPYYR..VRRD..CPSG.HPPWP...EGICTKCQ.PS.AISLQP.....QEFRMVD......HVEFASPDLINSLLDFWRKSG...................................
A0A7K9F3Z9_STEPR/106-246 .........................................................................................v-VEDEIDQYLIKQD..GKIYRNR.DQ.........Q.L............CRH...G.P..L.GKC......V.HCV.P...L.....E...............PFDE.DYL..N..HLEp......pVKHMSFHAYIRKLTGG...A...D...K-.......-.................-...-..-............GKF.......VA.L...ENISCK..IKSG..CEG-.HPPWP...EGICTKCQ.PS.AITLNR.....QKYRHVD......NIMFENHTIADRFLDFWRKTG...................................
G9NW97_HYPAI/127-270 ..........................................................................................VKQSALDDRLDKLD..GKIPRGR.D-.........R.M............CRH...G.P..K.GMC......D.YCQ.P...L.....D...............PFNP.GYL..A..DNG........IKYPSFHAHLRKINSA...T...N...KP.......E.................S...G..T............SYI.......PP.L...VEPYFR..VKRD..CPSG.HPAWP...EGICTKCQ.PS.AITLNP.....QTFRMVD......HVEFSSPSIIDGFIDTWRKTG...................................
A0A2J6QFW8_9HELO/139-283 ..........................................................................................VKQSALDDRLDKLN..GKIPRKR.DV.........K.M............CRH...G.E..K.GMC......D.YCM.P...L.....E...............PFNV.EYL..K..EKK........IKNLSFHSHLRKINSA...T...N...KP.......E.................L...G..S............SFM.......PP.L...TEPYYR..VKRD..CPSG.HPQWP...EGICTKCQ.PS.AITLQP.....QPFRMVD......HVEFANATVIDNLLQFWRASG...................................
A0A7L4CB36_9AVES/77-217 .........................................................................................v-VEDEIDQYLIKQD..GKIYRSR.DQ.........Q.L............CRH...G.P..L.GKC......V.HCV.P...L.....E...............PFDE.DYL..N..HLEp......pVKHMSFHAYIRKLTGG...A...D...K-.......-.................-...-..-............GKF.......VA.L...ENISCK..IKSG..CEG-.HPPWP...EGICTKCQ.PS.AITLNR.....QKYRHVD......NIMFENHTIADRFLDFWRKTG...................................
NPL4_VANPO/102-245 .........................................................................................i-SELPVDVLLEKED..GLIKRTR.S-.........S.L............CKH...G.D..K.GMC......E.YCS.P...L.....P...............PWDK.EYH..A..ENK........LKHISFHSYLKKLNEA...T...N...KK.......S.................S...G..S............SYI.......PP.L...SQPDYK..INKR..CNNG.HEPWP...RGICSKCQ.PS.AITLQQ.....QEFRMVD......HVEIQQSDLINQFIESWRATG...................................
A0A2V1AQG5_9ASCO/113-256 ..........................................................................................VKQHPVDDLLDKSE..GLIKRPK.S-.........S.F............CSH...G.D..K.GMC......E.YCS.P...L.....P...............PWDK.NYL..K..EQG........IKHKSFHAYLKEMNEQ...Q...N...NK.......S.................K...A..S............SYI.......AP.L...QDLNYA..INLH..CPGG.HAPYP...GGICSKCQ.PA.PITLQQ.....QPFRMVD......HVEFSDHSLLNTFIDVWRQSG...................................
A0A1V9XBA3_9ACAR/118-255 ..........................................................................................VEDDEVDRVLAKMD..GKIARPR.G-.........A.L............CRH...N.E..S.SRC......V.HCI.P...L.....E...............PFDE.AYL..A..ERK........IKHLSFHSYLKKLTSG...A...D...K-.......-.................-...-..-............GKF.......AN.L...ENISCK..IKPN..CSG-.HPPWP...KGICSKCQ.PT.ALTLNL.....QKYRHVD......CIMFENRHIVDRFLDFWRRS-s..................................
A0A7L4MH72_GLAPT/106-246 .........................................................................................v-VEDEIDQYLIKQD..GKIYRNR.DQ.........Q.L............CRH...G.P..L.GKC......V.HCV.P...L.....E...............PFDE.DYL..N..HLEp......pVKHMSFHAYIRKLTGG...A...D...K-.......-.................-...-..-............GKF.......VA.L...ENISCK..IKSG..CEG-.HPPWP...EGICTKCQ.PS.AITLNR.....QKYRHVD......NIMFENHTIADRFLDFWRKTG...................................
#=GC seq_cons ............................................................................................pDtlDphLtKpD..GKI.RsR.D..........p.h............CRH...G.s..h.GhC......s.aCh.P...L.....E...............PaDc.cYL..s..chc........lKHhSFHAYlRKLsuu...s...s...K..............................................uth.......ss.L...-slsh+..lKss..Cpu..HPPWP...cGICTKCQ.PS.AITLpp.....QpYRtVD......pl.Fpstsls-+FLDaWRKTG...................................
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