GenomeNet

Database: Pfam
Entry: zf_C2H2_13
LinkDB: zf_C2H2_13
Original site: zf_C2H2_13 
#=GF ID   zf_C2H2_13
#=GF AC   PF18508.2
#=GF DE   Zinc finger domain
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF02228
#=GF GA   26.50 26.50;
#=GF TC   26.50 26.50;
#=GF NC   26.40 26.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   20434206
#=GF RT   Structural basis for assembly and activation of the
#=GF RT   heterotetrameric SAGA histone H2B deubiquitinase module.
#=GF RA   Kohler A, Zimmerman E, Schneider M, Hurt E, Zheng N;
#=GF RL   Cell. 2010;141:606-617.
#=GF RN   [2]
#=GF RM   20395473
#=GF RT   Structural insights into the assembly and function of the SAGA
#=GF RT   deubiquitinating module.
#=GF RA   Samara NL, Datta AB, Berndsen CE, Zhang X, Yao T, Cohen RE,
#=GF RA   Wolberger C;
#=GF RL   Science. 2010;328:1025-1029.
#=GF RN   [3]
#=GF RM   22771212
#=GF RT   A role for intersubunit interactions in maintaining SAGA
#=GF RT   deubiquitinating module  structure and activity.
#=GF RA   Samara NL, Ringel AE, Wolberger C;
#=GF RL   Structure. 2012;20:1414-1424.
#=GF RN   [4]
#=GF RM   25526805
#=GF RT   Uncovering the role of Sgf73 in maintaining SAGA
#=GF RT   deubiquitinating module structure and activity.
#=GF RA   Yan M, Wolberger C;
#=GF RL   J Mol Biol. 2015;427:1765-1778.
#=GF DR   INTERPRO; IPR041251;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   The SAGA (Spt-Ada-Gcn5-acetyltransferase) complex performs
#=GF CC   multiple functions in transcription activation including
#=GF CC   deubiquitinating histone H2B, which is mediated by a subcomplex
#=GF CC   called the deubiquitinating module (DUBm). The yeast DUBm
#=GF CC   comprises a catalytic subunit, Ubp8, and three additional
#=GF CC   subunits, Sgf11, Sus1 and Sgf73, all of which are required for
#=GF CC   DUBm activity. A portion of the non-globular Sgf73 subunit lies
#=GF CC   between the Ubp8 catalytic domain and the zinc finger (ZnF)-UBP
#=GF CC   domain and has been proposed to contribute to deubiquitinating
#=GF CC   activity by maintaining the catalytic domain in an active
#=GF CC   conformation. Sgf73 contributes to maintaining both the
#=GF CC   organization and ubiquitin-binding conformation of Ubp8, thereby
#=GF CC   contributing to overall DUBm activity. This domain is a Sgf73
#=GF CC   fragment in the DUB module. It is a zinc finger (ZnF) domain
#=GF CC   whose integrity is essential for the incorporation of this
#=GF CC   subunit into DUBm as well as for the catalytic activity of Ubp8,
#=GF CC   as either a short deletion or point mutations in Sgf73
#=GF CC   zinc-coordinating residues disrupt the association of Sgf73 with
#=GF CC   the rest of the DUBm [1 -4].
#=GF SQ   31
#=GS C5DU26_ZYGRC/63-106       AC C5DU26.1
#=GS A0A167S6B2_CALVF/19-52    AC A0A167S6B2.1
#=GS I2GZ14_TETBL/70-112       AC I2GZ14.1
#=GS C5E2D7_LACTC/55-96        AC C5E2D7.1
#=GS A0A1G4M9A6_LACFM/54-95    AC A0A1G4M9A6.1
#=GS A0A1E5RDM2_9ASCO/68-108   AC A0A1E5RDM2.1
#=GS A0A0C7NAE6_9SACH/55-96    AC A0A0C7NAE6.1
#=GS A0A1G4KAL7_9SACH/56-97    AC A0A1G4KAL7.1
#=GS M5G5Y7_DACPD/66-101       AC M5G5Y7.1
#=GS G0VEK5_NAUCC/54-95        AC G0VEK5.1
#=GS G8JP42_ERECY/69-107       AC G8JP42.1
#=GS G8ZVX5_TORDC/61-103       AC G8ZVX5.1
#=GS A0A1G4JRS0_9SACH/55-96    AC A0A1G4JRS0.1
#=GS G8BYW8_TETPH/70-113       AC G8BYW8.1
#=GS A0A1E4U3E1_PACTA/89-122   AC A0A1E4U3E1.1
#=GS SGF73_YEAST/59-100        AC P53165.1
#=GS SGF73_YEAST/59-100        DR PDB; 4ZUX n; 59-98;
#=GS SGF73_YEAST/59-100        DR PDB; 4ZUX i; 59-98;
#=GS SGF73_YEAST/59-100        DR PDB; 4FJC D; 59-96;
#=GS SGF73_YEAST/59-100        DR PDB; 6AQR E; 59-95;
#=GS SGF73_YEAST/59-100        DR PDB; 4FK5 E; 59-95;
#=GS SGF73_YEAST/59-100        DR PDB; 4ZUX Y; 59-98;
#=GS SGF73_YEAST/59-100        DR PDB; 3M99 D; 59-98;
#=GS SGF73_YEAST/59-100        DR PDB; 3MHH E; 59-96;
#=GS SGF73_YEAST/59-100        DR PDB; 2LO3 A; 1-42;
#=GS SGF73_YEAST/59-100        DR PDB; 3MHS E; 59-95;
#=GS SGF73_YEAST/59-100        DR PDB; 4ZUX d; 59-98;
#=GS SGF73_YEAST/59-100        DR PDB; 4FIP D; 59-95;
#=GS SGF73_YEAST/59-100        DR PDB; 4FJC H; 59-95;
#=GS SGF73_YEAST/59-100        DR PDB; 4FIP H; 59-96;
#=GS A7TE81_VANPO/66-109       AC A7TE81.1
#=GS W0TA98_KLUMD/51-92        AC W0TA98.1
#=GS H2B1T6_KAZAF/51-94        AC H2B1T6.1
#=GS A0A1E3QYW2_9ASCO/62-99    AC A0A1E3QYW2.1
#=GS Q755C0_ASHGO/70-105       AC Q755C0.1
#=GS A0A1D2VH95_9ASCO/149-190  AC A0A1D2VH95.1
#=GS Q6CWP9_KLULA/57-95        AC Q6CWP9.1
#=GS A0A1G4K355_9SACH/55-96    AC A0A1G4K355.1
#=GS K0KX27_WICCF/73-110       AC K0KX27.1
#=GS S6ECV9_ZYGB2/63-106       AC S6ECV9.1
#=GS A0A1X7R004_9SACH/51-91    AC A0A1X7R004.1
#=GS G0WFT5_NAUDC/53-94        AC G0WFT5.1
#=GS A0A0X8HTX9_9SACH/65-107   AC A0A0X8HTX9.1
#=GS Q6FJK0_CANGA/52-93        AC Q6FJK0.1
#=GS J7RMR6_KAZNA/56-94        AC J7RMR6.1
C5DU26_ZYGRC/63-106                  ............NSNT.RIIEN.PLETSasFQYRVCNSCGKPLALNAIVDHLENHCKG...
A0A167S6B2_CALVF/19-52               ..........aa----.-----.PMHDD..LDLRVCKDCGKPVLASAAAAHLEN-CK-k..
I2GZ14_TETBL/70-112                  ............NPNV.RLLEDsPLDLN..LKYRICNKCGKPLSSDSIIDHLEKFCKG...
C5E2D7_LACTC/55-96                   ..........rd--SA.SIIKN.PLDKP..LDYRICDGCGKPVSLSAIVEHLQTYCKG...
A0A1G4M9A6_LACFM/54-95               ...........n-TSG.TIIDN.PLGQP..LEYRVCNSCGKPISLSVIVEHLKSHCKG...
A0A1E5RDM2_9ASCO/68-108              ...........s-SNV.EILPN.PIQNR..INLRVCNNCNKPLTPTAIQKHV-AFCN-n..
A0A0C7NAE6_9SACH/55-96               ............NDPS.SILED.PLGSA..LEYRVCEKCGKPVSLSALVDHLQIHCKG...
A0A1G4KAL7_9SACH/56-97               ............NQNG.RLIRD.PIGEP..LNYRLCNNCDRPVSVSAIVQHLESDC--pa.
M5G5Y7_DACPD/66-101                  ........fgaa----.-----.PMHDE..LDVRVCKDCGKPVLASAVAAHLEN-CK-k..
G0VEK5_NAUCC/54-95                   ..........rr--DA.HIIEA.PLESL..SEFRVCKKCGKPIKLTALVDHLENNCS-i..
G8JP42_ERECY/69-107                  .lsntvpvinlp----.-----.-----..IEYRTCNDCGRPIAYSALIDHLQNHCRG...
G8ZVX5_TORDC/61-103                  ............NSNA.KIIED.PLEES.aFNYRICNSCGAPLALNSIMDHLENHCKG...
A0A1G4JRS0_9SACH/55-96               ............NDSA.SILEN.PLGQS..LEYRVCESCGKPVSLGAIVEHLQIHCKG...
G8BYW8_TETPH/70-113                  ............NSNT.HFIDN.GLATNnyTNYRLCNACGKPISIEVIMDHLKTYCSK...
A0A1E4U3E1_PACTA/89-122              ..........cg----.----N.PLGAP..INYRICNHCDRPILETFLADHIKS----cv.
SGF73_YEAST/59-100                   ............NPNA.QLIED.PLDKP..IQYRVCEKCGKPLALTAIVDHLENHCAG...
#=GR SGF73_YEAST/59-100        SS    ............-TTS.---SS.TTSSS..--EEEETTT--EEEGGGHHHHHHHTXTT...
A7TE81_VANPO/66-109                  ............NANT.HLLEN.TVESNssSNYRICNSCGRPISLETIVDHLNNHCNS...
W0TA98_KLUMD/51-92                   ..........sr--PS.EILPS.VLKED..IRYRECIACHQPVLVSGIVEHLEKYC--ia.
H2B1T6_KAZAF/51-94                   ............NPNTkRLLVD.NLDFN.sLTFKVCNNCKIPISANAIDDHLRSCCT-s..
A0A1E3QYW2_9ASCO/62-99               ......pqdelg----.---TN.PLAAP..LNYRVCNHCNRPILASHIAKHIT-----dc.
Q755C0_ASHGO/70-105                  .........tva----.-----.PLEPP..VDYRVCNDCGRPIAYSALLVHLQEHCR-r..
A0A1D2VH95_9ASCO/149-190             ...........k--NP.NLITNnPLSKP..FKYRICNICQRPILESVLIDHLNNC---ikn
Q6CWP9_KLULA/57-95                   ...sevlsgvsk----.-----.----E.dIRYRNCTACHQPVLVSAIIDHLENHC--id.
A0A1G4K355_9SACH/55-96               ............NESA.SILEN.PLGQP..LEYRVCEGCGKPVNLGAIVDHLQVHCKG...
K0KX27_WICCF/73-110                  .......knnln----.--LKN.PLNQI..VNYRVCNLCDRPILIDHLTKHIKT----c..
S6ECV9_ZYGB2/63-106                  ............NSNT.HIIEN.PLEPSasFQYRVCNSCGKPLALNAIMEHLEDHCKG...
A0A1X7R004_9SACH/51-91               ............NPNA.NII--.PTENA.fAGYRICKSCGKPILLNSIIDHIQNHCP-g..
G0WFT5_NAUDC/53-94                   ...........s-ENA.TIIED.SLDTL..SEYRVCNQCGKPIKLYALIAHLENGCKS...
A0A0X8HTX9_9SACH/65-107              ksqylsnniqis----.-----.---SS.pIEYRTCNDCGRPISYAALIDHLHNYCV-g..
Q6FJK0_CANGA/52-93                   ............EPNT.RIIID.ALDKQ..TNFRVCKGCGKPILLEAIVDHIENHCSN...
J7RMR6_KAZNA/56-94                   .....vaedsyf----.-----.-VDTD..FNFRVCRGCGRPIALRALEAHLASGCA-a..
#=GC SS_cons                         ............-TTS.---SS.TTSSS..--EEEETTT--EEEGGGHHHHHHHTXTT...
#=GC seq_cons                        ..............ss.pll.s.PLpps..lpYRlCssCG+PlslsAIl-HLcsaCp....
//
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