GenomeNet

Database: Pfam
Entry: zf_C2H2_13
LinkDB: zf_C2H2_13
Original site: zf_C2H2_13 
#=GF ID   zf_C2H2_13
#=GF AC   PF18508.1
#=GF DE   Zinc finger domain
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF02228
#=GF GA   26.50 26.50;
#=GF TC   26.50 26.90;
#=GF NC   26.30 26.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   20434206
#=GF RT   Structural basis for assembly and activation of the
#=GF RT   heterotetrameric SAGA histone H2B deubiquitinase module.
#=GF RA   Kohler A, Zimmerman E, Schneider M, Hurt E, Zheng N;
#=GF RL   Cell. 2010;141:606-617.
#=GF RN   [2]
#=GF RM   20395473
#=GF RT   Structural insights into the assembly and function of the SAGA
#=GF RT   deubiquitinating module.
#=GF RA   Samara NL, Datta AB, Berndsen CE, Zhang X, Yao T, Cohen RE,
#=GF RA   Wolberger C;
#=GF RL   Science. 2010;328:1025-1029.
#=GF RN   [3]
#=GF RM   22771212
#=GF RT   A role for intersubunit interactions in maintaining SAGA
#=GF RT   deubiquitinating module  structure and activity.
#=GF RA   Samara NL, Ringel AE, Wolberger C;
#=GF RL   Structure. 2012;20:1414-1424.
#=GF RN   [4]
#=GF RM   25526805
#=GF RT   Uncovering the role of Sgf73 in maintaining SAGA
#=GF RT   deubiquitinating module structure and activity.
#=GF RA   Yan M, Wolberger C;
#=GF RL   J Mol Biol. 2015;427:1765-1778.
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   The SAGA (Spt-Ada-Gcn5-acetyltransferase) complex performs
#=GF CC   multiple functions in transcription activation including
#=GF CC   deubiquitinating histone H2B, which is mediated by a subcomplex
#=GF CC   called the deubiquitinating module (DUBm). The yeast DUBm
#=GF CC   comprises a catalytic subunit, Ubp8, and three additional
#=GF CC   subunits, Sgf11, Sus1 and Sgf73, all of which are required for
#=GF CC   DUBm activity. A portion of the non-globular Sgf73 subunit lies
#=GF CC   between the Ubp8 catalytic domain and the zinc finger (ZnF)-UBP
#=GF CC   domain and has been proposed to contribute to deubiquitinating
#=GF CC   activity by maintaining the catalytic domain in an active
#=GF CC   conformation. Sgf73 contributes to maintaining both the
#=GF CC   organization and ubiquitin-binding conformation of Ubp8, thereby
#=GF CC   contributing to overall DUBm activity. This domain is a Sgf73
#=GF CC   fragment in the DUB module. It is a zinc finger (ZnF) domain
#=GF CC   whose integrity is essential for the incorporation of this
#=GF CC   subunit into DUBm as well as for the catalytic activity of Ubp8,
#=GF CC   as either a short deletion or point mutations in Sgf73
#=GF CC   zinc-coordinating residues disrupt the association of Sgf73 with
#=GF CC   the rest of the DUBm [1 -4].
#=GF SQ   36
#=GS C5DU26_ZYGRC/63-106       AC C5DU26.1
#=GS J8Q556_SACAR/59-100       AC J8Q556.1
#=GS A0A167S6B2_9BASI/19-52    AC A0A167S6B2.1
#=GS I2GZ14_TETBL/70-112       AC I2GZ14.1
#=GS W1QJ00_OGAPD/65-105       AC W1QJ00.1
#=GS A0A1G4KAL7_9SACH/56-97    AC A0A1G4KAL7.1
#=GS G0VEK5_NAUCC/54-95        AC G0VEK5.1
#=GS A0A1G4JRS0_9SACH/55-96    AC A0A1G4JRS0.1
#=GS A0A1E4U3E1_PACTA/89-122   AC A0A1E4U3E1.1
#=GS A0A1E3QYW2_9ASCO/62-99    AC A0A1E3QYW2.1
#=GS A0A1D2VH95_9ASCO/149-190  AC A0A1D2VH95.1
#=GS Q6CWP9_KLULA/57-95        AC Q6CWP9.1
#=GS A0A1G4K355_9SACH/55-96    AC A0A1G4K355.1
#=GS K0KX27_WICCF/73-110       AC K0KX27.1
#=GS E7LUD6_YEASV/15-40        AC E7LUD6.2
#=GS S6ECV9_ZYGB2/63-106       AC S6ECV9.1
#=GS G0WFT5_NAUDC/53-94        AC G0WFT5.1
#=GS J7RMR6_KAZNA/56-94        AC J7RMR6.1
#=GS A0A1E3NT41_9ASCO/87-121   AC A0A1E3NT41.1
#=GS C5E2D7_LACTC/55-96        AC C5E2D7.1
#=GS A0A1G4M9A6_LACFM/54-95    AC A0A1G4M9A6.1
#=GS A0A1E5RDM2_9ASCO/68-108   AC A0A1E5RDM2.1
#=GS A0A0C7NAE6_9SACH/55-96    AC A0A0C7NAE6.1
#=GS G8JP42_ERECY/69-107       AC G8JP42.1
#=GS G8ZVX5_TORDC/61-103       AC G8ZVX5.1
#=GS H0GG90_SACCK/59-100       AC H0GG90.1
#=GS G8BYW8_TETPH/70-113       AC G8BYW8.1
#=GS SGF73_YEAST/59-100        AC P53165.1
#=GS SGF73_YEAST/59-100        DR PDB; 4ZUX n; 59-98;
#=GS SGF73_YEAST/59-100        DR PDB; 4ZUX i; 59-98;
#=GS SGF73_YEAST/59-100        DR PDB; 4FJC D; 59-96;
#=GS SGF73_YEAST/59-100        DR PDB; 4FK5 E; 59-95;
#=GS SGF73_YEAST/59-100        DR PDB; 4ZUX Y; 59-98;
#=GS SGF73_YEAST/59-100        DR PDB; 3M99 D; 59-98;
#=GS SGF73_YEAST/59-100        DR PDB; 3MHH E; 59-96;
#=GS SGF73_YEAST/59-100        DR PDB; 2LO3 A; 1-42;
#=GS SGF73_YEAST/59-100        DR PDB; 3MHS E; 59-95;
#=GS SGF73_YEAST/59-100        DR PDB; 4ZUX d; 59-98;
#=GS SGF73_YEAST/59-100        DR PDB; 4FIP D; 59-95;
#=GS SGF73_YEAST/59-100        DR PDB; 4FJC H; 59-95;
#=GS SGF73_YEAST/59-100        DR PDB; 4FIP H; 59-96;
#=GS A7TE81_VANPO/66-109       AC A7TE81.1
#=GS W0TA98_KLUMD/51-92        AC W0TA98.1
#=GS H2B1T6_KAZAF/51-94        AC H2B1T6.1
#=GS Q755C0_ASHGO/70-105       AC Q755C0.1
#=GS M5G5Y7_DACPD/67-101       AC M5G5Y7.1
#=GS A0A1X7R004_9SACH/51-91    AC A0A1X7R004.1
#=GS Q6FJK0_CANGA/52-93        AC Q6FJK0.1
#=GS I2K335_DEKBR/85-118       AC I2K335.2
C5DU26_ZYGRC/63-106                  .........NSNT.RIIEN.PLETSasFQYRVCNSCGKPLALNAIVDHLENHCKG....
J8Q556_SACAR/59-100                  .........KPNA.QLIEN.PLDTP..IQFRVCEKCGKPLALTAIVDHLENHCAG....
A0A167S6B2_9BASI/19-52               .......aa----.-----.PMHDD..LDLRVCKDCGKPVLASAAAAHLEN-CK-k...
I2GZ14_TETBL/70-112                  .........NPNV.RLLEDsPLDLN..LKYRICNKCGKPLSSDSIIDHLEKFCKG....
W1QJ00_OGAPD/65-105                  ..enndlqs----.---KN.PLSRP..VVYRICNHCDRPILEKYLADHLKS----caq.
A0A1G4KAL7_9SACH/56-97               .........NQNG.RLIRD.PIGEP..LNYRLCNNCDRPVSVSAIVQHLESDC--pa..
G0VEK5_NAUCC/54-95                   .......rr--DA.HIIEA.PLESL..SEFRVCKKCGKPIKLTALVDHLENNCS-i...
A0A1G4JRS0_9SACH/55-96               .........NDSA.SILEN.PLGQS..LEYRVCESCGKPVSLGAIVEHLQIHCKG....
A0A1E4U3E1_PACTA/89-122              .......cg----.----N.PLGAP..INYRICNHCDRPILETFLADHIKS----cv..
A0A1E3QYW2_9ASCO/62-99               ...pqdelg----.---TN.PLAAP..LNYRVCNHCNRPILASHIAKHIT-----dc..
A0A1D2VH95_9ASCO/149-190             ........k--NP.NLITNnPLSKP..FKYRICNICQRPILESVLIDHLNNC---ikn.
Q6CWP9_KLULA/57-95                   sevlsgvsk----.-----.----E.dIRYRNCTACHQPVLVSAIIDHLENHC--id..
A0A1G4K355_9SACH/55-96               .........NESA.SILEN.PLGQP..LEYRVCEGCGKPVNLGAIVDHLQVHCKG....
K0KX27_WICCF/73-110                  ....knnln----.--LKN.PLNQI..VNYRVCNLCDRPILIDHLTKHIKT----c...
E7LUD6_YEASV/15-40                   .....ieca----.-----.-----..------KKCGKPLALTAIVDHLENHCAG....
S6ECV9_ZYGB2/63-106                  .........NSNT.HIIEN.PLEPSasFQYRVCNSCGKPLALNAIMEHLEDHCKG....
G0WFT5_NAUDC/53-94                   ........s-ENA.TIIED.SLDTL..SEYRVCNQCGKPIKLYALIAHLENGCKS....
J7RMR6_KAZNA/56-94                   ..vaedsyf----.-----.-VDTD..FNFRVCRGCGRPIALRALEAHLASGCA-a...
A0A1E3NT41_9ASCO/87-121              ......ssr----.-----.PLTQP..INYRICNSCGTAILEKNMADHIS-HCS-t...
C5E2D7_LACTC/55-96                   .......rd--SA.SIIKN.PLDKP..LDYRICDGCGKPVSLSAIVEHLQTYCKG....
A0A1G4M9A6_LACFM/54-95               .......nt--SG.TIIDN.PLGQP..LEYRVCNSCGKPISLSVIVEHLKSHCKG....
A0A1E5RDM2_9ASCO/68-108              ........s-SNV.EILPN.PIQNR..INLRVCNNCNKPLTPTAIQKHV-AFCN-n...
A0A0C7NAE6_9SACH/55-96               .........NDPS.SILED.PLGSA..LEYRVCEKCGKPVSLSALVDHLQIHCKG....
G8JP42_ERECY/69-107                  lsntvpvin----.-----.---LP..IEYRTCNDCGRPIAYSALIDHLQNHCRG....
G8ZVX5_TORDC/61-103                  .........NSNA.KIIED.PLEES.aFNYRICNSCGAPLALNSIMDHLENHCKG....
H0GG90_SACCK/59-100                  .........NPNA.QLIED.PLDKP..IQYRVCEKCGKPLALTAIVDHLENHCAG....
G8BYW8_TETPH/70-113                  .........NSNT.HFIDN.GLATNnyTNYRLCNACGKPISIEVIMDHLKTYCSK....
SGF73_YEAST/59-100                   .........NPNA.QLIED.PLDKP..IQYRVCEKCGKPLALTAIVDHLENHCAG....
#=GR SGF73_YEAST/59-100        SS    .........-TTS.---SS.TTSSS..--EEEETTT--EEEGGGHHHHHHHTXTT....
A7TE81_VANPO/66-109                  .........NANT.HLLEN.TVESNssSNYRICNSCGRPISLETIVDHLNNHCNS....
W0TA98_KLUMD/51-92                   .......sr--PS.EILPS.VLKED..IRYRECIACHQPVLVSGIVEHLEKYC--ia..
H2B1T6_KAZAF/51-94                   .........NPNTkRLLVD.NLDFN.sLTFKVCNNCKIPISANAIDDHLRSCCT-s...
Q755C0_ASHGO/70-105                  ......tva----.-----.PLEPP..VDYRVCNDCGRPIAYSALLVHLQEHCR-r...
M5G5Y7_DACPD/67-101                  ......gaa----.-----.PMHDE..LDVRVCKDCGKPVLASAVAAHLEN-CK-k...
A0A1X7R004_9SACH/51-91               .........NPNA.NII--.PTENA.fAGYRICKSCGKPILLNSIIDHIQNHCP-g...
Q6FJK0_CANGA/52-93                   .........EPNT.RIIID.ALDKQ..TNFRVCKGCGKPILLEAIVDHIENHCSN....
I2K335_DEKBR/85-118                  .......sr----.----D.PLEKP..VSYRICNICDNPILESSMADHI------vqcq
#=GC SS_cons                         .........-TTS.---SS.TTSSS..--EEEETTT--EEEGGGHHHHHHHTXTT....
#=GC seq_cons                        ...........ss.pll.s.PLpps..lpYRlCssCG+PltlsAIlDHLcsaCt.....
//
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