GenomeNet

Database: Pfam
Entry: AHSP
LinkDB: AHSP
Original site: AHSP 
#=GF ID   AHSP
#=GF AC   PF09236.10
#=GF DE   Alpha-haemoglobin stabilising protein
#=GF AU   Sammut SJ;0000-0003-4472-904X
#=GF SE   pdb_1w09
#=GF GA   20.50 20.50;
#=GF TC   20.60 22.30;
#=GF NC   20.10 20.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   15178680
#=GF RT   NMR structure of the alpha-hemoglobin stabilizing protein:
#=GF RT   insights into conformational heterogeneity and binding. 
#=GF RA   Santiveri CM, Perez-Canadillas JM, Vadivelu MK, Allen MD,
#=GF RA   Rutherford TJ, Watkins NA, Bycroft M; 
#=GF RL   J Biol Chem. 2004;279:34963-34970.
#=GF DR   INTERPRO; IPR015317;
#=GF DR   SCOP; 1w09; fa;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Alpha-haemoglobin stabilising protein (AHSP) acts a molecular
#=GF CC   chaperone for free alpha-haemoglobin, preventing the harmful
#=GF CC   aggregation of alpha-haemoglobin during normal erythroid cell
#=GF CC   development: it specifically protects free alpha-haemoglobin
#=GF CC   from precipitation. AHSP adopts a helical secondary structure
#=GF CC   consisting of an elongated antiparallel three alpha-helix bundle
#=GF CC   [1].
#=GF SQ   44
#=GS H2NS04_PONAB/5-91        AC H2NS04.1
#=GS W5PJ79_SHEEP/5-91        AC W5PJ79.1
#=GS A0A0D9QZX6_CHLSB/5-91    AC A0A0D9QZX6.1
#=GS G3T391_LOXAF/5-91        AC G3T391.1
#=GS A0A1U7UJ94_TARSY/5-91    AC A0A1U7UJ94.1
#=GS A0A1S3A6A8_ERIEU/5-91    AC A0A1S3A6A8.1
#=GS S7NJK5_MYOBR/5-91        AC S7NJK5.1
#=GS A0A1D5RDT9_MACMU/5-91    AC A0A1D5RDT9.1
#=GS A9UMW3_RAT/5-91          AC A9UMW3.1
#=GS A0A1U8BWH0_MESAU/5-91    AC A0A1U8BWH0.1
#=GS A0A091D6K8_FUKDA/5-91    AC A0A091D6K8.1
#=GS M3YIT3_MUSPF/5-91        AC M3YIT3.1
#=GS M3W8I5_FELCA/5-91        AC M3W8I5.2
#=GS G3RD35_GORGO/5-91        AC G3RD35.1
#=GS T0NQX3_CAMFR/7-93        AC T0NQX3.1
#=GS G3IJS0_CRIGR/5-91        AC G3IJS0.1
#=GS A0A2K5NXR4_CERAT/5-91    AC A0A2K5NXR4.1
#=GS AHSP_BOVIN/5-91          AC Q865F8.1
#=GS E2RSC2_CANLF/5-91        AC E2RSC2.1
#=GS F1MER2_BOVIN/1-67        AC F1MER2.2
#=GS A0A096NI01_PAPAN/5-91    AC A0A096NI01.1
#=GS G1P6I0_MYOLU/5-91        AC G1P6I0.1
#=GS H3BSK6_HUMAN/5-57        AC H3BSK6.1
#=GS A0A1A6GB31_NEOLE/5-91    AC A0A1A6GB31.1
#=GS AHSP_HUMAN/5-91          AC Q9NZD4.1
#=GS AHSP_HUMAN/5-91          DR PDB; 1XZY A; 5-90;
#=GS AHSP_HUMAN/5-91          DR PDB; 1Y01 A; 5-91;
#=GS AHSP_HUMAN/5-91          DR PDB; 3OVU A; 5-91;
#=GS AHSP_HUMAN/5-91          DR PDB; 1W0A A; 5-91;
#=GS AHSP_HUMAN/5-91          DR PDB; 3IA3 C; 5-91;
#=GS AHSP_HUMAN/5-91          DR PDB; 3IA3 A; 5-91;
#=GS AHSP_HUMAN/5-91          DR PDB; 1Z8U A; 5-91;
#=GS AHSP_HUMAN/5-91          DR PDB; 1Z8U C; 5-91;
#=GS AHSP_HUMAN/5-91          DR PDB; 1W0B A; 5-91;
#=GS AHSP_HUMAN/5-91          DR PDB; 1W09 A; 5-91;
#=GS AHSP_MOUSE/5-91          AC Q9CY02.1
#=GS D2HTC9_AILME/5-91        AC D2HTC9.1
#=GS G1TJ87_RABIT/5-91        AC G1TJ87.1
#=GS F6RED9_MACMU/24-110      AC F6RED9.2
#=GS F7EDV6_ORNAN/5-92        AC F7EDV6.1
#=GS F7B0H6_CALJA/5-91        AC F7B0H6.1
#=GS Q4XCU6_PLACH/38-89       AC Q4XCU6.1
#=GS A0A1U7Q2Z0_MESAU/34-120  AC A0A1U7Q2Z0.1
#=GS G5BYB6_HETGA/5-104       AC G5BYB6.1
#=GS F7DP52_MONDO/4-90        AC F7DP52.1
#=GS A0A2I3HXI8_NOMLE/5-91    AC A0A2I3HXI8.1
#=GS H2QB08_PANTR/5-91        AC H2QB08.1
#=GS H0XCX0_OTOGA/5-91        AC H0XCX0.1
#=GS L9KTP8_TUPCH/5-91        AC L9KTP8.1
#=GS F6RTV5_HORSE/5-91        AC F6RTV5.1
#=GS A0A1S3ERA3_DIPOR/5-91    AC A0A1S3ERA3.1
#=GS G3WLQ8_SARHA/5-89        AC G3WLQ8.1
#=GS A0A287AK38_PIG/5-91      AC A0A287AK38.1
#=GS G7Q110_MACFA/5-91        AC G7Q110.1
H2NS04_PONAB/5-91                   ..KANKDLISAGLKEF....SVLLNQ.........QVFNDPL.ISEEDMVTVVEDWMNFYINYYRQQVTGEPQERDKALQELRQELNTLANPFLAKYRDFLKS..
W5PJ79_SHEEP/5-91                   ..QTNKDLISKGIKEF....NILLNQ.........QVFSDPA.ISEEAMVTVVNDWVSFYINYYKKQLSGEQQEQDRVLQEFRQELDTLSASFLEKYRNFLKS..
A0A0D9QZX6_CHLSB/5-91               ..KANKDLISAGRQEF....SVLLNQ.........QVFNDPL.ISEEDMVTVVEDWMNFYINYYRQQVTGEPQERDRALQELRQELNTLANPFLAKYRDFLKS..
G3T391_LOXAF/5-91                   ..QANKDLISTGMKEF....SILLNQ.........QDMRDNP.IPEEAMVIVVNDWMSFYINYYRQKMTGEQQEQDRALQELQQGLNTLANPFLTKYRDFLKT..
A0A1U7UJ94_TARSY/5-91               ..QANKDLISTGKKEF....NVLLSQ.........QVFGDPL.ISEEAMVIVVNDWINFYINYYKQKITGEQQEQDMALQELQQELNTLASPFLDKYRAFLKS..
A0A1S3A6A8_ERIEU/5-91               ..QTNKDLIAKGIKEF....TALLDQ.........QVFSHPF.VSEEDMVVIVKDWMDLYTNYYTNQLTGECQEKDMALQELREGMLALSEPFLDKYREHIKS..
S7NJK5_MYOBR/5-91                   ..QANKDLISTGMKEF....NALLNQ.........QVFSDPP.VSEEAMVTMVEDWVNFYINYYKQQMTGEQQEQDRALEELRQELNTLSAPFLAKYRAFLKS..
A0A1D5RDT9_MACMU/5-91               ..KANKDLISAGRQEF....GVLLNQ.........QVFNDPL.ISEEDMVTVVEDWMNFYINYYRQQVTGEPQERDRALQELRQELNTLANPFLAKYRDFLKS..
A9UMW3_RAT/5-91                     ..QSNKDLISTGIKEF....NVLLDQ.........QVFDDPL.MPEEDMKTVVNDWVNLYINYYKKHVLGEQQEQDGALKELQQELSTLGSQFLAKYRIILKS..
A0A1U8BWH0_MESAU/5-91               ..QTNEELISTGIKQF....NVLLDQ.........QVFSDPL.IPEEGMVTVVDDWVNLYINYYKPLVLGGQQEQDKTLQELQQELKTLGSQFLTKYRTFLKS..
A0A091D6K8_FUKDA/5-91               ..QANKDLISMGMKEF....SVLLNQ.........QVFNYPL.ITEEDMVIVVDDWVNIYINYYRKRLTGEKQEQDRALQKLRQELKTLANPFLAKYKAFLKS..
M3YIT3_MUSPF/5-91                   ..QANKDLISTGMKEF....NVLLNQ.........QVFPNPP.LPEEAMVTMVDDWVNFYINYYRKQMVGEQQEQERALQELEQELRTLSAPFLTKYRAFLKS..
M3W8I5_FELCA/5-91                   ..QANKDLISKGMKEF....NILLDQ.........QVFPNPS.IPEEAMVTIVDDWVNFYINYYRTQVVGEQQEQERALQELRQELNTLSAPFLAKYRAFLKS..
G3RD35_GORGO/5-91                   ..KANKDLISAGLKEF....SVLLNQ.........QVFNDPL.ISEEDMVTVVEDWMNFYINYYRQQVTGEPQERDKALQELRQELNTLANPFLAKYRDFLKS..
T0NQX3_CAMFR/7-93                   ..QTNKDLISAGIKEF....KTLLNQ.........QVFSDPV.ISEEAMETVANDWVNFYINYYRQQMVGEQQEQDRALQELRQELTTLAASFLDKYRNFLKS..
G3IJS0_CRIGR/5-91                   ..QTNKELISEGIKQF....NVLLGQ.........QVFDDPL.IPEENMVTVVNDWVNLYINYYKPLVFGKQQEQDKALQELQQELNTLGSQFLTKYRTILKS..
A0A2K5NXR4_CERAT/5-91               ..KANKDLISAGRQEF....SVLLNQ.........QVFNDPL.ISEEDMVIVVEDWMNFYINYYRQQVTGEPQERDRALQEFRQELNTLANPFLAKYRDFLKS..
AHSP_BOVIN/5-91                     ..QTNKDLISKGIKEF....NILLNQ.........QVFSDPA.ISEEAMVTVVNDWVSFYINYYKKQLSGEQDEQDKALQEFRQELNTLSASFLDKYRNFLKS..
E2RSC2_CANLF/5-91                   ..QANKDLISTGIKEF....NVLLNQ.........QVFPNPP.IPEEAMVTMVNDWVNFYINYYRQKMVGEQQEQEKALQELQQELNTLSAPFLEKYRAFLK-h.
F1MER2_BOVIN/1-67                   ..--------------....------.........QVFSDPA.ISEEAMVTVVNDWVSFYINYYKKQLSGEQDEQDKALQEFRQELNTLSASFLDKYRNFLKS..
A0A096NI01_PAPAN/5-91               ..KANKDLISAGRQEF....SVLLNQ.........QVFNDPL.ISEEDMVTVVEDWMNFYINYYRQQVTGEPQERDRALQEFRQELNTLANPFLAKYRDFLKS..
G1P6I0_MYOLU/5-91                   .p-ANKDLISTGMKEF....NALLNQ.........QVFSDPP.VSEEAMVTMVNDWVNFYINYYKQQMTGEEQEQDRALEELRQELNTLSVPFLAKYRAFLKS..
H3BSK6_HUMAN/5-57                   ..KANKDLISAGLKEF....SVLLNQ.........QVFNDPL.VSEEDMVTVVEDWMNFYINYYRQQVT----------------------------------..
A0A1A6GB31_NEOLE/5-91               ..QTNKELVSTGIKEF....NVLLNQ.........QVFNDLL.IPEESMVTVVDDWVNLYINYYKKQVLGEQQEQDKALQELRQELNTLGSQFLTKYRTFLKS..
AHSP_HUMAN/5-91                     ..KANKDLISAGLKEF....SVLLNQ.........QVFNDPL.VSEEDMVTVVEDWMNFYINYYRQQVTGEPQERDKALQELRQELNTLANPFLAKYRDFLKS..
#=GR AHSP_HUMAN/5-91          SS    ..HHHHHHHHHHHHHH....HHHHHT.........S-CCSS-.S-HHHHHHHHHHHHHHHHHHHHTT--SSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH..
AHSP_MOUSE/5-91                     ..QSNKDLISTGIKEF....NVLLDQ.........QVFDDPL.ISEEDMVIVVHDWVNLYTNYYKKLVHGEQEEQDRAMTEFQQELSTLGSQFLAKYRTFLKS..
D2HTC9_AILME/5-91                   ..QANKDLISTGMKEF....NVLLNQ.........QVFPNPP.VPEEAMVTMVEDWVNFYINYYRTQMVGEQQEQESALRELQQELNALSAPFLVKYRAFLKS..
G1TJ87_RABIT/5-91                   .p-TNKDLISMGLKEF....NVLLNQ.........QVFSDPL.LSQEAMQTVLDDWVNLYVNYYRQQMTGEQQELDKALEELRLELNGLAKPFLNKYSVFLKS..
F6RED9_MACMU/24-110                 ..KANKDLISAGRQEF....GVLLNQ.........QVFNDPL.ISEEDMVTVVEDWMNFYINYYRQQVTGEPQERDRALQELRQELNTLANPFLAKYRDFLKS..
F7EDV6_ORNAN/5-92                   .h-SNQDVINSAMAAF....QALLNQ.........QVFSPQIpIPMEAMKIIVRDWIEFYISYFAPKLRGDRQERERAQEDLWETLQAIARPFLDKYRDFLNA..
F7B0H6_CALJA/5-91                   ..KANKDLISAGLKEF....NVLLNQ.........QVFNDPL.ISEEDMVIVVEDWMNFYINYYRQQVTGDPQERDKALQELRQELNTLINPFLAKYRDFLKS..
Q4XCU6_PLACH/38-89                  si--DKDIVLLQLENF....SKKVDE.........DIFDEKV.FRAQKLIDHVKKYVEYYINYFKK-------------------------------------in
A0A1U7Q2Z0_MESAU/34-120             ..QTNEELISTGIKQF....NVLLDQ.........QVFSDPL.IPEEGMVTVVDDWVNLYINYYKPLVLGGQQEQDKTLQELQQELKTLGSQFLTKYRTFLKS..
G5BYB6_HETGA/5-104                  ..QANKDLIALGMKEFpadySDMLEShslspashpQVFNYPL.ITEEDMVVVVDDWVNIYINYYRKRLTGEKQDQDRALQELRQELKTLASPFLAKYRACLES..
F7DP52_MONDO/4-90                   ..QSNQDVISSAMQEF....NKLLNQ.........QDFTYAV.ISEKDMVTIVDDWMNYYLSFFSQKMSGDQQEQERAMQKLQEELRSSANPFLDKYRAFLKS..
A0A2I3HXI8_NOMLE/5-91               ..KANTDLISAGLKEF....SVLLNQ.........QVFNDPL.ISEEDMVTVVEDWMNFYINYYRRQVTGEPQERDKALQELRQELNTLANHFLAKYRDFLKS..
H2QB08_PANTR/5-91                   ..KANKDLISAGLKEF....SVLLNQ.........QVFNDPL.VSEEDMVTVVEDWMNFYINYYRQQVTGEPQERDKALQELRQELNTLANPFLAKYRDFLKS..
H0XCX0_OTOGA/5-91                   ..QANEDLISAGVKEF....NILLNQ.........QVFNEPF.VSEEAMETVVNDWVNFYMNYYKKQMTGEQGEQEKALQELKQKLNSLANPFLAKYRAFLKS..
L9KTP8_TUPCH/5-91                   ..QVNKDIIATGMKKF....SVLLDQ.........QVFSEPP.ISEEAMVVVVNDWVNFYVNYYGQQVTGEQQEQDRALNELRQELTTMASPFLAKYRAFLKS..
F6RTV5_HORSE/5-91                   ..QANRDLISTAIKEF....NVLLNQ.........QVFSDPP.VSEEAMVTVVNDWVNFYINYYRRQVVGEQQEKDRALQELRQELNILSAPFLAKYRAFLKS..
A0A1S3ERA3_DIPOR/5-91               .p-ANKDLISKGVKEF....SVLLNQ.........QVFEDPL.VSEDDMEKVVNDWMNIYINYYSKHVVGEPQEQDTALKELQQELKSLSSPFLDKYKTFLKS..
G3WLQ8_SARHA/5-89                   ..QSNQDVISSAMQEF....SKLLDQ.........QEFTKPA.FSETDMVTIVDDWIKFYLSYYSKKMTGNEQEQERAMQKLQEELRTSASPFLDKSQS----in
A0A287AK38_PIG/5-91                 .p-TNQDLISAGIKEF....NILLNQ.........QVFSEPA.IPEEAMVTVVNDWMDLYLNYYKKKMVGEQEEQDKALQELRQELNTLSASFLDKYRNFLKS..
G7Q110_MACFA/5-91                   ..KANKDLISAGRQEF....GVLLNQ.........QVFNDPL.ISEEDMVTVVEDWMNFYINYYRQQVTGEPQERDRALQELRQELNTLANPFLAKYRDFLKS..
#=GC SS_cons                        ..HHHHHHHHHHHHHH....HHHHHT.........S-CCSS-.S-HHHHHHHHHHHHHHHHHHHHTT--SSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH..
#=GC seq_cons                       ..puNKDLISsGhKEF....sVLLNQ.........QVFsDPl.ISEEsMVTVVcDWhNFYINYY+pQloGEpQEpD+ALQELRQELNTLusPFLsKYRsFLKS..
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