GenomeNet

Database: Pfam
Entry: APOBEC4
LinkDB: APOBEC4
Original site: APOBEC4 
#=GF ID   APOBEC4
#=GF AC   PF18775.2
#=GF DE   APOBEC4
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF AU   Burroughs AM;0000-0002-2229-8771
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   Iyer LM
#=GF GA   27.20 27.20;
#=GF TC   27.20 27.50;
#=GF NC   26.10 26.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   21890906
#=GF RT   Evolution of the deaminase fold and multiple origins of
#=GF RT   eukaryotic editing and mutagenic nucleic acid deaminases from
#=GF RT   bacterial toxin systems.
#=GF RA   Iyer LM, Zhang D, Rogozin IB, Aravind L;
#=GF RL   Nucleic Acids Res. 2011; [Epub ahead of print]
#=GF RN   [2]
#=GF RM   29555751
#=GF RT   Diversification of AID/APOBEC-like deaminases in metazoa:
#=GF RT   multiplicity of clades  and widespread roles in immunity.
#=GF RA   Krishnan A, Iyer LM, Holland SJ, Boehm T, Aravind L;
#=GF RL   Proc Natl Acad Sci U S A. 2018;115:E3201.
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   A member of the AID/APOBEC family of cytosine deaminases. The
#=GF CC   biological function of APOBEC4 is poorly understood. However, it
#=GF CC   is widely conserved across vertebrates [1].
#=GF SQ   28
#=GS K7G211_PELSI/24-97       AC K7G211.1
#=GS F6SPN1_CIOIN/83-162      AC F6SPN1.2
#=GS A0A091IKM1_CALAN/1-70    AC A0A091IKM1.1
#=GS A0A091G380_9AVES/22-106  AC A0A091G380.1
#=GS A0A091V9F4_NIPNI/1-65    AC A0A091V9F4.1
#=GS H2YIR4_CIOSA/107-194     AC H2YIR4.1
#=GS A0A091UXU5_NIPNI/21-105  AC A0A091UXU5.1
#=GS A0A087QVF4_APTFO/22-106  AC A0A087QVF4.1
#=GS A0A2P8Y320_BLAGE/1-70    AC A0A2P8Y320.1
#=GS A0A2T7P0M1_POMCA/76-175  AC A0A2T7P0M1.1
#=GS A0A091ETZ4_CORBR/1-64    AC A0A091ETZ4.1
#=GS A0A099ZZR5_CHAVO/1-65    AC A0A099ZZR5.1
#=GS A0A091WDY6_OPIHO/1-75    AC A0A091WDY6.1
#=GS A0A091G853_9AVES/1-70    AC A0A091G853.1
#=GS A0A1S3T3Q2_SALSA/94-170  AC A0A1S3T3Q2.1
#=GS W5MW91_LEPOC/15-99       AC W5MW91.1
#=GS K7G211_PELSI/212-285     AC K7G211.1
#=GS A0A087QNJ4_APTFO/1-65    AC A0A087QNJ4.1
#=GS A0A2B4SME3_STYPI/91-177  AC A0A2B4SME3.1
#=GS A0A093HKT8_STRCA/22-106  AC A0A093HKT8.1
#=GS A0A099ZXL0_CHAVO/22-106  AC A0A099ZXL0.1
#=GS A0A1S3ITD1_LINUN/89-180  AC A0A1S3ITD1.1
#=GS A0A093I8Y9_STRCA/1-74    AC A0A093I8Y9.1
#=GS F6S0S9_CIOIN/277-366     AC F6S0S9.2
#=GS A0A1U7S0S1_ALLSI/79-152  AC A0A1U7S0S1.1
#=GS A0A3M6T8U8_9CNID/74-160  AC A0A3M6T8U8.1
#=GS H0ZSB5_TAEGU/2-76        AC H0ZSB5.1
#=GS A0A091WIF8_OPIHO/22-106  AC A0A091WIF8.1
K7G211_PELSI/24-97                  ...................LTWYM..TWSP..CGE....CCKAIRDFL.........KEQP...NV.N.LV...IYVARIYCHE......................EENNRQGLRSLVNIG....VTIRIM.......DL.P...VYSYCWRTFV......................................
F6SPN1_CIOIN/83-162                 ..................v-TVELmsSRSP..SNA....GAEQLQGFLe......ycKKHS..iKV.N.IN...FSFVQPFSWD......................NKFNREGLHNLYEKG....VKLKIL.......SF.Q...QVINCMMGD-l.....................................
A0A091IKM1_CALAN/1-70               ...................ITWYL..SWSP..CAC....CCCKIQDFL.........KMNS...YV.N.TD...IDVAQLYGNY......................QEQNCQGLKNLKSLA...rVTIAVM.......RI.E...DKISC-----......................................
A0A091G380_9AVES/22-106             ...................IILYS..SYSP..CNEvphcCVSKIYNFS.........LKYP...EI.T.LC...IYFSQLYHTQag.................cpsAAWNREALRSLWSLWp..rVTLQRP.......PG.E...LWPSLLCPFV......................................
A0A091V9F4_NIPNI/1-65               ...................ITWYL..SRSP..CAK....CCYEILDFL.........NKHS...NV.N.ID...IYIAQLYKIK......................NEENCQGLRNLVSLA...kVTIAVM.......EI.-...----------e.....................................
H2YIR4_CIOSA/107-194                ...............vdiv----M..SSSP..IHQ....CSETLLKLVqlektflrhR--NfdgQL.N.VT...IRFAHSYGWDvkd................daiRERVHDGLRNLFREG....VNLEVM.......SA.D...----------iildeirv..............................
A0A091UXU5_NIPNI/21-105             ...................IILYS..NYSP..CNEayhcCISKIYNFL.........LKYP...EI.T.LC...IYFSQLYHTEdg.................fptAAWNREALRSLSSLWp..rVTLQRL.......PG.G...TWRYLLCNFV......................................
A0A087QVF4_APTFO/22-106             ...................IILYS..TYSP..CNEayhcCISKIYNFL.........LKYP...EI.T.LC...IYFSQLYHTEdg.................sptAAWNREALRSLSSLWp..rVTLQRL.......PA.G...AQRYLLCNFV......................................
A0A2P8Y320_BLAGE/1-70               ...................----M..SYSP..CGT....CTDAIIPFT.........EKRP...NC.N.VC...IAFSCLYRHK.....................kEEVHRDGLRQLNAEP...rISIKVF.......TK.I...EWKTL-----aqa...................................
A0A2T7P0M1_POMCA/76-175             .................ik--IYI..SFSP..CHQ....CSQKLIALLdh.....akLNYN..iDL.K.VE...IVFAGLYRIFrpscisnftncvshlsrfpfkhNGKNVQGMMNLHSKG....VHLRTF.......DD.Q...DWLDLLK---gl....................................
A0A091ETZ4_CORBR/1-64               ...................ITWYL..SWSP..CMT....CCYIIRNFL.........VRHP...NV.N.IE...IHVARLYNTR......................WAGTRRGLRELARLRg..rVTIDVM.......--.-...----------e.....................................
A0A099ZZR5_CHAVO/1-65               ...................ITWYL..SWSP..CAE....CCLKILNFL.........EENS...NV.N.ID...IHIARLYRIQ......................DERNRQGLRELVSSE...eVTIAVM.......GI.-...----------e.....................................
A0A091WDY6_OPIHO/1-75               ...................ITWYL..SWSP..CAN....CCRKILNFL.........KKHS...YV.N.ID...IRVARLYYIQ......................VERNLQGLKKLESLA...nVTIGVM.......KI.K...DYTDCWKIFI......................................
A0A091G853_9AVES/1-70               ...................ITWFL..SWSP..CAD....CCRKIMDFL.........MKHS...YV.N.ID...IRVARLYFIE......................DPKIRQGLKNLVSLA...gVNIAVM.......EI.K...----------gkvfc.................................
A0A1S3T3Q2_SALSA/94-170             ..................e-VLYS..NYMP..CQE....CSQTLISFL.........LRYP...WV.R.LD...LLFSQLYHTAps.................qthSLDNQTGLRSLAV--....LTLSPN.......SG.A...AWGHLLRCFV......................................
W5MW91_LEPOC/15-99                  ...................VTLYS..NYTP..CEEppgrCASALTHFL.........QAHP...AL.R.LD...LLFSQLYHTEdw.................hpyGSANRQALRALGALWp..rLTLSPI.......SG.G...WWLSLLRKFV......................................
K7G211_PELSI/212-285                ...................VTWFL..SWSP..CWK....CSQSVVEFR.........KAYP...KV.N.LE...IYVARLFRHE......................EECNRQGLRDLVMNG....VTIRVM.......NL.S...AYNYCWRTFV......................................
A0A087QNJ4_APTFO/1-65               ...................ITWYL..SWSP..CAD....CCRKILNFL.........KKNS...NV.N.ID...IYVARLYYTE......................DEKIRQGLQNLVSLA...eVTIAVM.......ET.-...----------e.....................................
A0A2B4SME3_STYPI/91-177             .........ltgflhdfql---LS..NFSP..CGE....CSEKICEWL.........AQNE...SV.S.VS...IRFAHLHNIHvrv................qkvAEDNAIGLRKLVEKG....VQLKAL.......SD.Y...DWLQLLMI--dr....................................
A0A093HKT8_STRCA/22-106             ...................IILYS..NYSP..CNEadhcCISKIYNFL.........IKHP...EV.T.LC...IYFSQLYHTEds.................fptAMWNREALRSLSSLWp..hVTLYPL.......SG.G...IRHYLLCNFV......................................
A0A099ZXL0_CHAVO/22-106             ...................IIVYS..NYSP..CNEayhcCVSKIYNFL.........LRYP...EI.T.LC...IYFSKLYHTEdr.................fptSVWNREALRSLSSLWp..qVTLQRL.......PG.G...AWHYLLCNFV......................................
A0A1S3ITD1_LINUN/89-180             .................ir--FYL..NWSP..CAR....CSSLFLNFSrm.....itEKKL...SI.D.LE...IVFRGLYEISrpsckgl........pcdcavrKPEHVQKLHALWRCE...hVTVRTF.......IE.E...DWKTLV----qll...................................
A0A093I8Y9_STRCA/1-74               ...................ITLYL..SWSP..CRN....CCYEMQYFL.........KKHP...NV.N.IC...IYLARLYYTE......................DEEICKALKDLSEKK....VIISVM.......KI.E...DYIYCWKTFV......................................
F6S0S9_CIOIN/277-366                ...............vdiv----M..SSSP..IHQ....CSETLLNLVqle..ktflKHRNfdgQL.N.VT...IRFAHSYGWDvkd................dviRERVHTGLRNLFKEG....VNLEIM.......SA.D...IILD------elrvdd................................
A0A1U7S0S1_ALLSI/79-152             ...................VTWYL..SWSP..CAD....CASKIVKFL.........KKYP...YL.K.LT...IYVAQLYYHT......................EEENRKGLRLLRSKK....VIIRVM.......DI.A...DYNYCWKVFV......................................
A0A3M6T8U8_9CNID/74-160             .........ftgflhdlql---LS..NFSP..CGE....CSEKICGWL.........AQND...SV.S.VS...IRFAHLHNIHvrv................qkvAEDNAIGLRKLVEKG....VQLKAL.......SD.Y...DWLQLLMI--dr....................................
H0ZSB5_TAEGU/2-76                   ...................MTWYL..SWSP..CGE....CCDIIQDFL.........EEQP...NV.N.IN...IRVARLYYTD......................RASNRKGLRELASSP...gVTLEIM.......DA.E...DYNYCWETFI......................................
A0A091WIF8_OPIHO/22-106             ...................IILYA..NYSP..CNEayhcCISKIYNFL.........LKYP...EI.T.LC...IYFSRLYHTEdg.................fptATWNQEALRSLSSLWp..rVTLQRL.......PA.G...TQHYLLLNFV......................................
#=GC seq_cons                       ...................lhhYh..SaSP..Csc....CspcIhsFL.........t+as...pl.s.ls...IhhApLYppc......................sppN+pGLRsLsuht...tVTlpsh.......st.t...thh.hhh.........................................
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