GenomeNet

Database: Pfam
Entry: Adeno_E3_CR1
LinkDB: Adeno_E3_CR1
Original site: Adeno_E3_CR1 
#=GF ID   Adeno_E3_CR1
#=GF AC   PF02440.16
#=GF DE   Adenovirus E3 region protein CR1
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_1854 (release 5.4)
#=GF GA   26.00 26.00;
#=GF TC   26.00 26.60;
#=GF NC   25.90 25.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   8627757
#=GF RT   Early region 3 of adenovirus type 19 (subgroup D) encodes an
#=GF RT   HLA-binding protein distinct from that of subgroups B and C. 
#=GF RA   Deryckere F, Burgert HG; 
#=GF RL   J Virol 1996;70:2832-2841.
#=GF DR   INTERPRO; IPR003471;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Early region 3 (E3) of human adenoviruses (Ads) codes for
#=GF CC   proteins that appear to control viral interactions with the host
#=GF CC   [1]. This region called CR1 (conserved region 1) [1] is found
#=GF CC   three times in Adenovirus type 19 (a subgroup D virus) 49 Kd
#=GF CC   protein in the E3 region. CR1 is also found in the 20.1 Kd
#=GF CC   protein of subgroup B adenoviruses. The function of this 80
#=GF CC   amino acid region is unknown. This region is probably a
#=GF CC   divergent immunoglobulin domain (A. Bateman pers. observation).
#=GF SQ   42
#=GS I3WF37_9BETA/30-134      AC I3WF37.1
#=GS Q4KSJ0_9ADEN/15-105      AC Q4KSJ0.1
#=GS Q3ZKT4_9ADEN/13-104      AC Q3ZKT4.1
#=GS K7ZQ33_ADE08/110-200     AC K7ZQ33.1
#=GS Q91CK3_ADE16/13-100      AC Q91CK3.1
#=GS C3UZL5_9ADEN/13-104      AC C3UZL5.1
#=GS Q91CK4_ADE16/13-104      AC Q91CK4.1
#=GS Q4KSJ0_9ADEN/110-200     AC Q4KSJ0.1
#=GS G8XT84_SCMVC/25-127      AC G8XT84.1
#=GS Q4KSJ0_9ADEN/254-339     AC Q4KSJ0.1
#=GS H5T763_9ADEN/253-339     AC H5T763.1
#=GS C4P226_9ADEN/17-107      AC C4P226.1
#=GS E1CIP8_9ADEN/15-105      AC E1CIP8.1
#=GS Q77N38_9ADEN/15-105      AC Q77N38.1
#=GS H5T763_9ADEN/130-219     AC H5T763.1
#=GS Q9PX39_ADE07/13-100      AC Q9PX39.1
#=GS C4P226_9ADEN/238-324     AC C4P226.1
#=GS Q9PX68_ADE07/13-104      AC Q9PX68.1
#=GS Q8BEL2_ADE04/22-115      AC Q8BEL2.1
#=GS Q7TFV8_RHCM6/30-134      AC Q7TFV8.1
#=GS A0A0K1H002_9BETA/31-137  AC A0A0K1H002.1
#=GS Q77N38_9ADEN/110-200     AC Q77N38.1
#=GS Q2Y0G3_ADE03/13-100      AC Q2Y0G3.1
#=GS Q8UY72_9ADEN/16-114      AC Q8UY72.1
#=GS H5T763_9ADEN/33-124      AC H5T763.1
#=GS Q76Y39_ADE35/14-100      AC Q76Y39.1
#=GS A0A0K0PY81_9ADEN/10-98   AC A0A0K0PY81.1
#=GS K7ZQ33_ADE08/15-105      AC K7ZQ33.1
#=GS C4P226_9ADEN/113-202     AC C4P226.1
#=GS Q3ZKT3_9ADEN/13-100      AC Q3ZKT3.1
#=GS E1CIP8_9ADEN/262-345     AC E1CIP8.1
#=GS A0A1L3INZ2_9ADEN/17-124  AC A0A1L3INZ2.1
#=GS G8XT85_SCMVC/21-123      AC G8XT85.1
#=GS K7ZQ33_ADE08/236-321     AC K7ZQ33.1
#=GS Q77N38_9ADEN/260-345     AC Q77N38.1
#=GS C7SRR3_9ADEN/13-104      AC C7SRR3.1
#=GS Q2Y0G4_ADE03/13-104      AC Q2Y0G4.1
#=GS G8XT76_SCMVC/110-209     AC G8XT76.1
#=GS I3WEY5_9BETA/38-141      AC I3WEY5.1
#=GS E1CIP8_9ADEN/110-200     AC E1CIP8.1
#=GS Q76Y40_ADE35/13-104      AC Q76Y40.1
#=GS A0A0K0PY77_9ADEN/68-155  AC A0A0K0PY77.1
I3WF37_9BETA/30-134                 sskkitcip---------VNS.TAGRNVTL....NPPpfnhHTTY..V.Y......WY.R-QLGK......GKNELC.....Ry..vpNK..QERNARIK......FQC.lSNY.SLLLINVTTSYNGNYTVN----..--....-----------ldlglgttsttcytltvkta
Q4KSJ0_9ADEN/15-105                 ......afg---QAGIHIINA.TWWDNITL....VGP....SDTP..V.T......WY.----DG......KGLQFC.....D.....GS..TVKNPQIR......HTC..NNQ.NLTLIHVNKTHERTYMGYRHDS..KG....KVDYKVTVIPP....................
Q3ZKT4_9ADEN/13-104                 ........v-TVAHGQTIVHI.TLGHNHTL....VGP...pITSE..V.I......WT.KLGSVD......YFDIIC.....N.....KT..EPIF----......VIC..NRQ.NLTLINVSKIYNGYYYGYDRSS..SQ....YKNYLVRITQP....................
K7ZQ33_ADE08/110-200                .....rkpl----SEPHYVTV.TMDHNITL....VGP....LNLP..V.T......WY.----DG......EGNKFC.....D.....GE..KVEHAEFN......HTC..NIQ.NLTLLFVNLTHNGAYIGYTKDG..SD....RELYEVSVKT-l...................
Q91CK3_ADE16/13-100                 ........a-AVTYGRSHLTV.PVGSTCTL....QGP....QEGH..V.T......WW.RIYDNG......GFARPC.....D.....QP..GTK-----......FSC..NGR.DLTIINITLNEQGFYYGTNYKN..--....SLDYNIIVVP-a...................
C3UZL5_9ADEN/13-104                 ........v-TAAHGQTVVSI.PLGHNYTL....IGP...pITSE..V.I......WT.KLGSVD......YFDIIC.....N.....KT..KPII----......VTC..NIQ.NLTLVNVSKVYSGYYYGYDRYS..SQ....YRNYLVRVTQ-s...................
Q91CK4_ADE16/13-104                 ........v-TVAHGQTIVHI.TLGHNHTL....VGP...pITSE..V.I......WT.KLGSVD......YFDIIC.....N.....KT..KPIF----......VIC..NRQ.NLTLINVSKIYNGYYYGYDRSS..SQ....YKNYLVRITQP....................
Q4KSJ0_9ADEN/110-200                ........v-KPQPDPENVFV.YMGDNVTL....VGP....QGIP..V.S......WY.----YH......NGTQFC.....N.....GD..KIIHPEFN......HTC..DKQ.NLTLLFVNFTHDGGYLGFNYKG..TQ....RIQYEVIVLD-r...................
G8XT84_SCMVC/25-127                 ..rckhtwl---------INA.TVNTNVTL....NGTm.vlNDCS..I.G......WY.--RNYG......AYEPLC.....Q.....YD..ATKSDKMTtykkihYTC..QNS.SLIIFNVNRSASGEYFTYGHYH..--....-----------ydcirekicykliill....
Q4KSJ0_9ADEN/254-339                ........p-TNTPETKQLTV.SIGSNLTL....VGP....-DGK..V.T......WY.----DG......DLKRPC.....E.....EQ..NYRL---P......HQC..SAQ.NLTLINVTKSHEGTYYGTNDKD..-E....SKRYRVKVNT-t...................
H5T763_9ADEN/253-339                ...qktlqt------TIQVMI.PIGTNYTL....VGP....-SPP..V.S......WH.--TTKN......GLTELC.....N.....GN..PILR----......HTC..DGQ.NITLINVNATFEADYYGSNNKS..-E....SKHYRVKVF--ke..................
C4P226_9ADEN/17-107                 .....sqgq----AVHVNLEI.CYGCNGTL....IGP....PKTP..V.E......WY.----DG......RGHKLC.....A.....GT..DTFRKELN......HTC..NLQ.NMTLTFVNLTHKGTYYGFGSDN..KN....SRVYQVTIKP-p...................
E1CIP8_9ADEN/15-105                 ........a-FSQAGFHTINA.TWWANITL....VGP....SDTP..V.T......WY.----DK......QGMQFC.....D.....GN..TVKNPQIR......HEC..NEQ.NLTLIHVNKTHERTYMGYNRQS..TH....KEDYKVIVIPP....................
Q77N38_9ADEN/15-105                 ........a-FSQAGFHTINA.TWWANITL....VGP....PDTP..V.T......WY.----DT......QGLWFC.....N.....GS..RVKNPQIR......HTC..NDQ.NLTLIHVNKTYERTYMGYNRQG..TK....KEDYKVVVIP-p...................
H5T763_9ADEN/130-219                ....atwap------PQDITI.KYGSNRTL....QGP....SVTP..V.S......WY.----DG......EGNRFC.....D.....GD..KIDHTEIN......HTC..NAQ.NLTLLFVNETHERTYYGISGDW..KQ....RNEYDVTVTK-t...................
Q9PX39_ADE07/13-100                 ........a-AVTYGRSHLTV.PVGSTCTL....QGP....QQGY..V.T......WW.RIYDNG......GFARPC.....D.....QP..GTK-----......FSC..NGR.DLTIINITSNEQGFYYGTNYKD..--....SLDYNIIVVP-a...................
C4P226_9ADEN/238-324                ..hehrdvv-------KEVSF.RTGTNQTL....VGP....PGSN..V.D......WL.KIGNGG......TFSELC.....K.....GD..DKH-----......YSC..NSQ.NLTIINVTRSDEGSYYGSNDDS..--....-AHYRVSVYDP....................
Q9PX68_ADE07/13-104                 ........v-TVAHGQTIIHI.TLGHNHTL....VGP...pITSE..V.I......WT.KLGSVD......YFDIIC.....N.....KT..KPIF----......VIC..NRQ.NLTLINVSKIYNGYYYGYDRSS..SQ....YKNYLVRITQP....................
Q8BEL2_ADE04/22-115                 ...prvsfi-------KPVNV.TEGSNVTL....VGV...eGAKN..T.T......WT.KYHLNG......W-KDIC.....N.....WS..VTV-----......YTC..EGV.NLTIVNATSAQNGRIQGQSVSD..SE....-----------gyytqhtfiydikvip....
Q7TFV8_RHCM6/30-134                 sskkitcip---------VNS.TAGRNVTL....NPPpfnhHTTY..V.Y......WY.R-QLGK......GKNELC.....Ry..vpNK..QERNARIK......FQC.lSNY.SLLLINVTTSYNGNYTVN----..--....-----------ldlglgttsttcytltvkta
A0A0K1H002_9BETA/31-137             ...hkcskt-------ETRTG.TVGTNITL....VTSpppnNKGL..L.Y......WY.KPNC-T......SNDRLC.....DysgftGN..NAVSNKTKl....kFSCmnNST.KLTLINVTAHYSGQYCSRTITS..NG....S----------vdicfnvtihl.........
Q77N38_9ADEN/110-200                ........v-KPQPEPEYVFV.YMGENKTL....EGP....PGTP..V.T......WF.----NQ......DGKKFC.....E.....GE..KVLHPEFN......HTC..DKQ.NLILLFVNFTHDGAYLGYNHQG..TQ....RTHYEVTVLD-l...................
Q2Y0G3_ADE03/13-100                 ........a-AVTYGRSHLTV.PVGSTCTL....QGP....QEGY..V.T......WW.RIYDNG......GFARPC.....D.....QP..GTK-----......FSC..NGR.DLTIINITSNEQGFYYGTNYKN..--....SLDYNIIVVP-a...................
Q8UY72_9ADEN/16-114                 ........v-IHGMSNEKITI.YTGTNHTL....KGP...eKATE..V.S......WYcYFNESD......VSTELC.....G.....NN..NKKNESITl...ikFQC..-GS.DLTLINITRDYVGMYYGTTAGI..SD....MEFYQVSVSEP....................
H5T763_9ADEN/33-124                 .....snge----AETVVVNV.KSGTNHTL....EGP....RKTP..V.Q......WY.---GGA......NFDMFC.....N.....GS..KIHHKELN......HTC..SIQ.NITLTFINRTHHGTYYGFGYDN..QN....SKVYHVRV---dve.................
Q76Y39_ADE35/14-100                 .......at--LTSARSHLTV.TIGSNCTL....KGP....QGGH..V.F......WW.RIYDNG......WFTKPC.....D.....QP..GR------......FFC..NGR.DLTIINVTANDKGFYYGTDYKS..--....SLDYNIIVLP-s...................
A0A0K0PY81_9ADEN/10-98              ..igivqgq--------DITIgYVGNNITL....LGP....STGT..IpT......WY.KIYERG......WWIRPC.....D.....QG..GSK-----......YIC..-TR.DLTITNLNTNDNGYYFCNNYGG..-G....KKSYTVEVRDP....................
K7ZQ33_ADE08/15-105                 ........a-FSQAGIINLNV.LWGINLTL....VGP....LDLP..V.T......WY.----DK......KGMQFC.....I.....GN..TIKNPQIK......HSC..DQQ.NLTLLNADKSHERTYLGYRHDS..KG....KVDYKVTVIPP....................
C4P226_9ADEN/113-202                .....rpll-----KPEDVVI.TKGNNKTL....VGP....PDTP..V.D......WY.----DG......SGHKLC.....K.....GK..EVHYPELN......HTC..NEQ.NLTLIFVNATFKGTYYGFRKDG..TD....KKEYRVTIDD-l...................
Q3ZKT3_9ADEN/13-100                 ........a-AVTYGRSHLTV.PVGSTCTL....QGP....QEGY..V.T......WW.RIYDNG......GFARPC.....D.....QP..GTK-----......FSC..NGR.DLTIINITLNEQGFYYGTNYKN..--....SLDYNIIVVP-a...................
E1CIP8_9ADEN/262-345                .......ph---TPEAKLITV.SSGSNLTL....LGP....-DGK..V.T......WY.----DD......DLKRPC.....E.....PG..YKLN----......CKC..DNQ.NLTLINVTKLYEGVYYGTNDGG..-N....GKRYRVKVNT-t...................
A0A1L3INZ2_9ADEN/17-124             ....sfnlp------TINITA.EYGSNLTLyafkQGEp..nNTDD..I.K......WF.KENTETisdslfTGRALC.....M.....KR..ISFSSHLH......FEC..DGY.NLRLLWLYYDYSGIYNVQKTVNntIH....NTYYNVTVVK-i...................
G8XT85_SCMVC/21-123                 .....hcsn----PGDIPISL.KLGDNVTL....NGT...lQSNH..S.T......RY.WYHNET......VLCKCT.....S.....GNpeTASGKKIT......FQC..HRNcSLTLINATVSHAGNYCVMNDFK..DEnptlQLCYNVTI---lss.................
K7ZQ33_ADE08/236-321                ........s-TNNLQPTQLYV.RPFTNVSL....TGP....PNGK..V.I......WY.----DG......ELNDPC.....E.....QK..YKLR----......TFC..NQQ.NLTLINVTSTYDGIYYGTDEKD..-K....ANRYRIKVNT-t...................
Q77N38_9ADEN/260-345                ......pat----IEAMLVTV.TAGSNLTL....VGP...kAEGK..V.T......WF.----DG......DLKRPC.....E.....PN..YRLR----......HEC..NNQ.NLTLINVTKDYEGTYYGTNDKD..-E....GKRYRVKVNT-t...................
C7SRR3_9ADEN/13-104                 ........v-TAAHGQTVVSI.PLGHNYTL....IGP...pITSE..V.I......WT.KLGSVD......YFDIIC.....N.....KT..KPII----......VTC..NIQ.NLTLINVSKVYSGYYYGYDRYS..SQ....YRNYLVRVTQ-s...................
Q2Y0G4_ADE03/13-104                 ........v-TVAHGQTIVHI.TLGHNHTL....VGP...pITSE..V.I......WT.KLGSVD......YFDIIC.....N.....KT..KPIF----......VIC..NRQ.NLTLINVSKIYNGYYYGYDRSS..SQ....YKNYLVRITQP....................
G8XT76_SCMVC/110-209                ...ndcycg--------SLTV.PVGANFTL....NGT....QDIDntI.S.....qW-.-FYANT......TRDLLCafwndN.....TN..YTM----Nhe.yvnYTC..TIE.HLLLLNLSTKNTGVYYNVKESV..PE....HTNYTFI----cynl................
I3WEY5_9BETA/38-141                 ...faynvt--------HVSG.YEHSNVTL....HTS...iSHSN..I.ShmnvgyWI.RYNYPV......NSYTIC.....T.....VS..GNNVASTKhn.gwfFEC..NGT.SLTLHNLNADHTGSYLFKNLLG..-L....MEHYTVTVLP-i...................
E1CIP8_9ADEN/110-200                ........v-KPQSGPEYVYV.NMGENKTL....VGP....PGIP..V.T......WY.----DG......EGNKFC.....D.....GK..KVEHAEFN......HTC..DVQ.NLTLLFINLTHDGAYLGYNHQG..TK....RTWYEVVVTD-g...................
Q76Y40_ADE35/13-104                 ........v-TAAHGQTVVSI.PLGHNYTL....IGP...pITSE..V.I......WT.KLGSVD......YFDIIC.....N.....KT..KPII----......VTC..NIQ.NLTLINVSKVYSGYYYGYDRYS..SQ....YRNYLVRVTQ-l...................
A0A0K0PY77_9ADEN/68-155             .....imvi----HGQTLINV.HPGTNHTL....VVP...kNYSN..I.E......WQ.WFTNNE......W-NEPC.....E.....HY..NL------......FIC..-NH.NLTLINVSTLHKGYYYRYDNHS..ID....PTIYLVRVNT-k...................
#=GC seq_cons                       ........s.....t.p.lsl.shGsNhTL....hGP.....ss...V.s......Wa.....ss......thsphC.....s.....ts..psh...........apC..stp.NLTLINVspsapGhYaGhspps...p....tppYpVpVh..h...................
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