GenomeNet

Database: Pfam
Entry: Adeno_E3_CR1
LinkDB: Adeno_E3_CR1
Original site: Adeno_E3_CR1 
#=GF ID   Adeno_E3_CR1
#=GF AC   PF02440.15
#=GF DE   Adenovirus E3 region protein CR1
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_1854 (release 5.4)
#=GF GA   26.00 26.00;
#=GF TC   26.00 26.60;
#=GF NC   25.90 24.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   8627757
#=GF RT   Early region 3 of adenovirus type 19 (subgroup D) encodes an
#=GF RT   HLA-binding protein distinct from that of subgroups B and C. 
#=GF RA   Deryckere F, Burgert HG; 
#=GF RL   J Virol 1996;70:2832-2841.
#=GF DR   INTERPRO; IPR003471;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Early region 3 (E3) of human adenoviruses (Ads) codes for
#=GF CC   proteins that appear to control viral interactions with the host
#=GF CC   [1]. This region called CR1 (conserved region 1) [1] is found
#=GF CC   three times in Adenovirus type 19 (a subgroup D virus) 49 Kd
#=GF CC   protein in the E3 region. CR1 is also found in the 20.1 Kd
#=GF CC   protein of subgroup B adenoviruses. The function of this 80
#=GF CC   amino acid region is unknown. This region is probably a
#=GF CC   divergent immunoglobulin domain (A. Bateman pers. observation).
#=GF SQ   38
#=GS I3WF37_9BETA/30-134      AC I3WF37.1
#=GS Q4KSJ0_9ADEN/15-105      AC Q4KSJ0.1
#=GS Q3ZKT4_9ADEN/13-104      AC Q3ZKT4.1
#=GS Q91CK3_ADE16/13-100      AC Q91CK3.1
#=GS C3UZL5_9ADEN/13-104      AC C3UZL5.1
#=GS Q4KSJ0_9ADEN/110-200     AC Q4KSJ0.1
#=GS Q91CK4_ADE16/13-104      AC Q91CK4.1
#=GS G8XT84_SCMVC/25-127      AC G8XT84.1
#=GS Q6QPD0_9ADEN/15-113      AC Q6QPD0.1
#=GS Q4KSJ0_9ADEN/254-339     AC Q4KSJ0.1
#=GS C4P226_9ADEN/17-107      AC C4P226.1
#=GS Q77N38_9ADEN/15-105      AC Q77N38.1
#=GS Q9PX39_ADE07/13-100      AC Q9PX39.1
#=GS C4P226_9ADEN/238-324     AC C4P226.1
#=GS B9A5S3_9ADEN/110-200     AC B9A5S3.1
#=GS Q9PX68_ADE07/13-104      AC Q9PX68.1
#=GS Q8BEL2_ADE04/22-115      AC Q8BEL2.1
#=GS Q7TFV8_RHCM6/30-134      AC Q7TFV8.1
#=GS A0A0K1H002_9BETA/31-137  AC A0A0K1H002.1
#=GS D2DMA7_ADE1A/14-100      AC D2DMA7.1
#=GS B9A5S3_9ADEN/15-105      AC B9A5S3.1
#=GS Q6QPD1_9ADEN/15-112      AC Q6QPD1.1
#=GS Q77N38_9ADEN/110-200     AC Q77N38.1
#=GS Q8UY72_9ADEN/16-114      AC Q8UY72.1
#=GS Q76Y39_ADE35/14-100      AC Q76Y39.1
#=GS A0A0K0PY81_9ADEN/10-98   AC A0A0K0PY81.1
#=GS B9A5S3_9ADEN/246-331     AC B9A5S3.1
#=GS Q6QPC9_9ADEN/21-114      AC Q6QPC9.1
#=GS C4P226_9ADEN/113-202     AC C4P226.1
#=GS Q3ZKT3_9ADEN/13-100      AC Q3ZKT3.1
#=GS A0A1L3INZ2_9ADEN/17-124  AC A0A1L3INZ2.1
#=GS G8XT85_SCMVC/21-123      AC G8XT85.1
#=GS Q77N38_9ADEN/260-345     AC Q77N38.1
#=GS C7SRR3_9ADEN/13-104      AC C7SRR3.1
#=GS G8XT76_SCMVC/110-209     AC G8XT76.1
#=GS I3WEY5_9BETA/38-141      AC I3WEY5.1
#=GS Q76Y40_ADE35/13-104      AC Q76Y40.1
#=GS A0A0K0PY77_9ADEN/68-155  AC A0A0K0PY77.1
I3WF37_9BETA/30-134                 sskkitcip---------VNS.TAGRNVTL....N....PPpfnhHTTY..V.Y......WY.R-QLGK......GKNELC.....Ry..vpNK..QERNARIK......FQC.lSNY.SLLLINVTTSYNGNYTVN----..--....-----------ldlglgttsttcytltvkta
Q4KSJ0_9ADEN/15-105                 ......afg---QAGIHIINA.TWWDNITL....V....GP....SDTP..V.T......WY.----DG......KGLQFC.....D.....GS..TVKNPQIR......HTC..NNQ.NLTLIHVNKTHERTYMGYRHDS..KG....KVDYKVTVIPP....................
Q3ZKT4_9ADEN/13-104                 ........v-TVAHGQTIVHI.TLGHNHTL....V....GP...pITSE..V.I......WT.KLGSVD......YFDIIC.....N.....KT..EPIF----......VIC..NRQ.NLTLINVSKIYNGYYYGYDRSS..SQ....YKNYLVRITQP....................
Q91CK3_ADE16/13-100                 ........a-AVTYGRSHLTV.PVGSTCTL....Q....GP....QEGH..V.T......WW.RIYDNG......GFARPC.....D.....QP..GTK-----......FSC..NGR.DLTIINITLNEQGFYYGTNYKN..--....SLDYNIIVVP-a...................
C3UZL5_9ADEN/13-104                 ........v-TAAHGQTVVSI.PLGHNYTL....I....GP...pITSE..V.I......WT.KLGSVD......YFDIIC.....N.....KT..KPII----......VTC..NIQ.NLTLVNVSKVYSGYYYGYDRYS..SQ....YRNYLVRVTQ-s...................
Q4KSJ0_9ADEN/110-200                ........v-KPQPDPENVFV.YMGDNVTL....V....GP....QGIP..V.S......WY.----YH......NGTQFC.....N.....GD..KIIHPEFN......HTC..DKQ.NLTLLFVNFTHDGGYLGFNYKG..TQ....RIQYEVIVLD-r...................
Q91CK4_ADE16/13-104                 ........v-TVAHGQTIVHI.TLGHNHTL....V....GP...pITSE..V.I......WT.KLGSVD......YFDIIC.....N.....KT..KPIF----......VIC..NRQ.NLTLINVSKIYNGYYYGYDRSS..SQ....YKNYLVRITQP....................
G8XT84_SCMVC/25-127                 ..rckhtwl---------INA.TVNTNVTL....N....GTm.vlNDCS..I.G......WY.--RNYG......AYEPLC.....Q.....YD..ATKSDKMTtykkihYTC..QNS.SLIIFNVNRSASGEYFTYGHYH..--....-----------ydcirekicykliill....
Q6QPD0_9ADEN/15-113                 .......al--CESVDRDVTI.TTGSNYTL....K....GP....PSGM..L.S......WYcYFGTDT......DQTELC.....N.....FQ..KGKTSNSKi...snYQC..NGT.DLILLNVTKAYGGSYYCPGQNT..EE....MIFYKVEVVDP....................
Q4KSJ0_9ADEN/254-339                ........p-TNTPETKQLTV.SIGSNLTL....V....GP....-DGK..V.T......WY.----DG......DLKRPC.....E.....EQ..NYRL---P......HQC..SAQ.NLTLINVTKSHEGTYYGTNDKD..-E....SKRYRVKVNT-t...................
C4P226_9ADEN/17-107                 .....sqgq----AVHVNLEI.CYGCNGTL....I....GP....PKTP..V.E......WY.----DG......RGHKLC.....A.....GT..DTFRKELN......HTC..NLQ.NMTLTFVNLTHKGTYYGFGSDN..KN....SRVYQVTIKP-p...................
Q77N38_9ADEN/15-105                 ........a-FSQAGFHTINA.TWWANITL....V....GP....PDTP..V.T......WY.----DT......QGLWFC.....N.....GS..RVKNPQIR......HTC..NDQ.NLTLIHVNKTYERTYMGYNRQG..TK....KEDYKVVVIP-p...................
Q9PX39_ADE07/13-100                 ........a-AVTYGRSHLTV.PVGSTCTL....Q....GP....QQGY..V.T......WW.RIYDNG......GFARPC.....D.....QP..GTK-----......FSC..NGR.DLTIINITSNEQGFYYGTNYKD..--....SLDYNIIVVP-a...................
C4P226_9ADEN/238-324                ..hehrdvv-------KEVSF.RTGTNQTL....V....GP....PGSN..V.D......WL.KIGNGG......TFSELC.....K.....GD..DKH-----......YSC..NSQ.NLTIINVTRSDEGSYYGSNDDS..--....-AHYRVSVYDP....................
B9A5S3_9ADEN/110-200                .....rkpl----SEPHYVTV.SMGDNITL....V....GP....SDLP..V.T......WY.----DG......EGNKFC.....D.....GE..KVEHAEFN......HTC..NIQ.NLTLLFVNLTHNGAYIGYNKDG..SD....RELYEVSVKT-l...................
Q9PX68_ADE07/13-104                 ........v-TVAHGQTIIHI.TLGHNHTL....V....GP...pITSE..V.I......WT.KLGSVD......YFDIIC.....N.....KT..KPIF----......VIC..NRQ.NLTLINVSKIYNGYYYGYDRSS..SQ....YKNYLVRITQP....................
Q8BEL2_ADE04/22-115                 ...prvsfi-------KPVNV.TEGSNVTL....V....GV...eGAKN..T.T......WT.KYHLNG......W-KDIC.....N.....WS..VTV-----......YTC..EGV.NLTIVNATSAQNGRIQGQSVSD..SE....-----------gyytqhtfiydikvip....
Q7TFV8_RHCM6/30-134                 sskkitcip---------VNS.TAGRNVTL....N....PPpfnhHTTY..V.Y......WY.R-QLGK......GKNELC.....Ry..vpNK..QERNARIK......FQC.lSNY.SLLLINVTTSYNGNYTVN----..--....-----------ldlglgttsttcytltvkta
A0A0K1H002_9BETA/31-137             ...hkcskt-------ETRTG.TVGTNITL....V....TSpppnNKGL..L.Y......WY.KPNC-T......SNDRLC.....DysgftGN..NAVSNKTKl....kFSCmnNST.KLTLINVTAHYSGQYCSRTITS..NG....S----------vdicfnvtihl.........
D2DMA7_ADE1A/14-100                 .......at--LTSARSHLTV.TIGSNCTL....K....GP....QGGH..V.F......WW.RIYDNG......WFTKPC.....D.....QP..GR------......FFC..NGR.DLTIINVTANDKGFYYGTDYKS..--....SLDYNIIVLP-s...................
B9A5S3_9ADEN/15-105                 .......ac--SQAGIINLNV.SWGMNLTL....V....GP....SDLP..V.T......WY.----DG......KGVQFC.....D.....GN..TIKNPQIK......HSC..DQQ.NLTLLNADKSHERTYLGYRHDS..KG....KVDYKVTVIPP....................
Q6QPD1_9ADEN/15-112                 .......ya--SGYANIQKTL.YVGSDGTL....E....GT...qSQAK..V.A......WY.FYRTNT......DPVKLC.....K.....GE..LPRTHKTPl....tFSC..SNN.NLTLFSITKQYTGTYYSTNFHT..GQ....DKYYTVKVENP....................
Q77N38_9ADEN/110-200                ........v-KPQPEPEYVFV.YMGENKTL....E....GP....PGTP..V.T......WF.----NQ......DGKKFC.....E.....GE..KVLHPEFN......HTC..DKQ.NLILLFVNFTHDGAYLGYNHQG..TQ....RTHYEVTVLD-l...................
Q8UY72_9ADEN/16-114                 ........v-IHGMSNEKITI.YTGTNHTL....K....GP...eKATE..V.S......WYcYFNESD......VSTELC.....G.....NN..NKKNESITl...ikFQC..-GS.DLTLINITRDYVGMYYGTTAGI..SD....MEFYQVSVSEP....................
Q76Y39_ADE35/14-100                 .......at--LTSARSHLTV.TIGSNCTL....K....GP....QGGH..V.F......WW.RIYDNG......WFTKPC.....D.....QP..GR------......FFC..NGR.DLTIINVTANDKGFYYGTDYKS..--....SLDYNIIVLP-s...................
A0A0K0PY81_9ADEN/10-98              ..igivqgq--------DITIgYVGNNITL....L....GP....STGT..IpT......WY.KIYERG......WWIRPC.....D.....QG..GSK-----......YIC..-TR.DLTITNLNTNDNGYYFCNNYGG..-G....KKSYTVEVRDP....................
B9A5S3_9ADEN/246-331                ........s-TNNLQPTQLYV.RPFTNVSL....T....GP....PNGK..V.T......WY.----DG......ELNDPC.....E.....QK..YKLR----......TFC..NQQ.NLTLINVTSTYDGIYYGTDEKD..-K....ANRYRIKVNT-t...................
Q6QPC9_9ADEN/21-114                 ..itrvsfi-------KHVNV.TEGDNITL....A....GV...eGAQN..T.T......WT.KYHL-G......W-RDIC.....T.....WN..VT------......YYC..IGV.NLTIVNANQSQNGLIKGQSVSV..TS....DGYY-------tqhsfnynitvip.......
C4P226_9ADEN/113-202                .....rpll-----KPEDVVI.TKGNNKTL....V....GP....PDTP..V.D......WY.----DG......SGHKLC.....K.....GK..EVHYPELN......HTC..NEQ.NLTLIFVNATFKGTYYGFRKDG..TD....KKEYRVTIDD-l...................
Q3ZKT3_9ADEN/13-100                 ........a-AVTYGRSHLTV.PVGSTCTL....Q....GP....QEGY..V.T......WW.RIYDNG......GFARPC.....D.....QP..GTK-----......FSC..NGR.DLTIINITLNEQGFYYGTNYKN..--....SLDYNIIVVP-a...................
A0A1L3INZ2_9ADEN/17-124             ....sfnlp------TINITA.EYGSNLTLyafkQ....GEp..nNTDD..I.K......WF.KENTETisdslfTGRALC.....M.....KR..ISFSSHLH......FEC..DGY.NLRLLWLYYDYSGIYNVQKTVNntIH....NTYYNVTVVK-i...................
G8XT85_SCMVC/21-123                 .....hcsn----PGDIPISL.KLGDNVTL....N....GT...lQSNH..S.T......RY.WYHNET......VLCKCT.....S.....GNpeTASGKKIT......FQC..HRNcSLTLINATVSHAGNYCVMNDFK..DEnptlQLCYNVTI---lss.................
Q77N38_9ADEN/260-345                ......pat----IEAMLVTV.TAGSNLTL....V....GP...kAEGK..V.T......WF.----DG......DLKRPC.....E.....PN..YRLR----......HEC..NNQ.NLTLINVTKDYEGTYYGTNDKD..-E....GKRYRVKVNT-t...................
C7SRR3_9ADEN/13-104                 ........v-TAAHGQTVVSI.PLGHNYTL....I....GP...pITSE..V.I......WT.KLGSVD......YFDIIC.....N.....KT..KPII----......VTC..NIQ.NLTLINVSKVYSGYYYGYDRYS..SQ....YRNYLVRVTQ-s...................
G8XT76_SCMVC/110-209                ...ndcycg--------SLTV.PVGANFTL....N....GT....QDIDntI.S.....qW-.-FYANT......TRDLLCafwndN.....TN..YTM----Nhe.yvnYTC..TIE.HLLLLNLSTKNTGVYYNVKESV..PE....HTNYTFI----cynl................
I3WEY5_9BETA/38-141                 ...faynvt--------HVSG.YEHSNVTL....H....TS...iSHSN..I.ShmnvgyWI.RYNYPV......NSYTIC.....T.....VS..GNNVASTKhn.gwfFEC..NGT.SLTLHNLNADHTGSYLFKNLLG..-L....MEHYTVTVLP-i...................
Q76Y40_ADE35/13-104                 ........v-TAAHGQTVVSI.PLGHNYTL....I....GP...pITSE..V.I......WT.KLGSVD......YFDIIC.....N.....KT..KPII----......VTC..NIQ.NLTLINVSKVYSGYYYGYDRYS..SQ....YRNYLVRVTQ-l...................
A0A0K0PY77_9ADEN/68-155             .....imvi----HGQTLINV.HPGTNHTL....V....VP...kNYSN..I.E......WQ.WFTNNE......W-NEPC.....E.....HY..NL------......FIC..-NH.NLTLINVSTLHKGYYYRYDNHS..ID....PTIYLVRVNT-k...................
#=GC seq_cons                       ........s.....t.p.lsl.shGsNhTL....h....GP....tssp..V.s......Wa.h...ss......thschC.....s.....ts..psh...........apC..ssp.NLTLINVopsasGhYaGhspps...p....ttpYpVpVh......................
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