GenomeNet

Database: Pfam
Entry: AfaD
LinkDB: AfaD
Original site: AfaD 
#=GF ID   AfaD
#=GF AC   PF05775.12
#=GF DE   Enterobacteria AfaD invasin protein
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_7107 (release 8.0)
#=GF GA   21.50 21.50;
#=GF TC   23.50 27.10;
#=GF NC   20.40 18.40;
#=GF BM   hmmbuild --amino HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   10981717
#=GF RT   Characterization of the AfaD-like family of invasins encoded by
#=GF RT   pathogenic Escherichia coli associated with intestinal and
#=GF RT   extra-intestinal infections. 
#=GF RA   Garcia MI, Jouve M, Nataro JP, Gounon P, Le Bouguenec C; 
#=GF RL   FEBS Lett 2000;479:111-117.
#=GF DR   INTERPRO; IPR008394;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of several AfaD and related proteins from
#=GF CC   Escherichia coli and Salmonella bacteria. The afa gene clusters
#=GF CC   encode an afimbrial adhesive sheath produced by Escherichia
#=GF CC   coli. The adhesive sheath is composed of two proteins, AfaD and
#=GF CC   AfaE, which are independently exposed at the bacterial cell
#=GF CC   surface.  AfaE is required for bacterial adhesion to HeLa cells
#=GF CC   and AfaD for the uptake of adherent bacteria into these cells
#=GF CC   [1]. 
#=GF SQ   8
#=GS A0A1H3WNY9_9GAMM/40-145  AC A0A1H3WNY9.1
#=GS A0A1S8YIS0_9ENTR/40-144  AC A0A1S8YIS0.1
#=GS L0MML6_9GAMM/38-139      AC L0MML6.1
#=GS A0A198FUH2_9GAMM/5-107   AC A0A198FUH2.1
#=GS A0A1S8YQ95_9ENTR/22-125  AC A0A1S8YQ95.1
#=GS A0A085U7D4_YERRU/40-144  AC A0A085U7D4.1
#=GS A0A1S8YKI4_9ENTR/40-144  AC A0A1S8YKI4.1
#=GS Q7CR56_SALTY/44-148      AC Q7CR56.1
#=GS Q7CR56_SALTY/44-148      DR PDB; 5Y9H B; 35-139;
#=GS Q7CR56_SALTY/44-148      DR PDB; 5Y9G A; 43-147;
#=GS Q7CR56_SALTY/44-148      DR PDB; 5Y9H A; 35-139;
#=GS Q7CR56_SALTY/44-148      DR PDB; 5Y9G B; 43-147;
#=GS Q7CR56_SALTY/44-148      DR PDB; 5Y9H C; 35-139;
A0A1H3WNY9_9GAMM/40-145             ...lq--AHVVKDGMRLGQGTLVSHEAHAGFRLWSEVQTSSFPT.GHFVLSGKQNDAHKLRIRLVPRGLTAEGSPGSSeMVLNTKD.D.RVVFDVIADGEQRVEADHYRLDI--sg..
A0A1S8YIS0_9ENTR/40-144             qdnrl------RDGGLIGSIRVTYREPHTEFQVWLEAEKSATAA.DRYVLTGKNDARNNLKIRLTGEGWTANANDGQS.GLTRQTT.DeQVSVNIVVDGNQETAPDEYVI----tana
L0MML6_9GAMM/38-139                 .nerq-----LSDGQIIGSGQVTYPGEHRGFQVWLTAEKQNGAA.ERYILRGSNNNAHRMFVRLERPEWHPDDIGKQG.IILYTGE.A.RADFNIVIDGDQAVAADNYA-----vpa.
A0A198FUH2_9GAMM/5-107              ...ml--AGTIFDNTLIGSGNILYAGDHDGFYLLSNKEMNKNISdGKWYLIGRNG--NFLKVKISGKEWLYDD--NQS.ALISTDKsK.IKEFFLYVDGKQNVVPDTYTIEL--ng..
A0A1S8YQ95_9ENTR/22-125             ...qm--AGTVKDGAILAKGRVFNADGAEGFTLWMEAASPAGAP.GYIIQ-SETDPTKKIRVRLAGRDWQVNPLNKNS.MISIRPA.P.SAAFLIVADGQQNIPAGSWRL----lvsa
A0A085U7D4_YERRU/40-144             ...ll--SGHVNGERRIGQGRIQYYGNHLGFQVWSDANKSGAQP.NSYVLLGKNNSSNKLRVRIEKKDWQPDHEGGKG.IILHYGG.E.TATFDVVIDGDQTVVADHYSLALN-a...
A0A1S8YKI4_9ENTR/40-144             ...mv--SGYLHDGTRIVLGRVISHLSHTAFHLWGDAQHSDTRP.TAYFLTGSQDSRHQLRVRLESDNGYADDKSGGG.LILPTIN.D.EASFYLVIDGDQNVIADSYSFGFAA....
Q7CR56_SALTY/44-148                 .....FRAGHVPDGMVLAQGWVTYHGSHSGFRVWSDEQKAGNTP.TVLLLSGQQDPRHHIQVRLEGEGWQPDTVSGRG.AILRTAA.D.NASFSVVVDGNQEVPADTWTLDFKA....
#=GR Q7CR56_SALTY/44-148      SS    .....EBSEEE-TT-EEEEEEEE--SS-SEEEEEESTBSCTSCT.TEEEEEBSSSTT-EEEEEEE-TT-EE-TTTSSS.EEEE---.S.EEEEEEEE-SSEEE-SEEEEEEEEE....
#=GC SS_cons                        .....EBSEEE-TT-EEEEEEEE--SS-SEEEEEESTBSCTSCT.TEEEEEBSSSTT-EEEEEEE-TT-EE-TTTSSS.EEEE---.S.EEEEEEEE-SSEEE-SEEEEEEEEE....
#=GC seq_cons                       ...hh..uGhlpDGtlIGpGpVhYtssHsGFplWu-Ap+uusss.spalLpGcsssp++L+VRLpucsWpsDs.sGpu.hILpTss.-.pAsFslVlDGcQsVsADsYslth..ss..
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