GenomeNet

Database: Pfam
Entry: Apelin
LinkDB: Apelin
Original site: Apelin 
#=GF ID   Apelin
#=GF AC   PF15360.7
#=GF DE   APJ endogenous ligand
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   Jackhmmer:Q9ULZ1
#=GF GA   27.00 27.00;
#=GF TC   32.70 32.40;
#=GF NC   21.90 21.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   11250876
#=GF RT   [(125)I]-(Pyr(1))Apelin-13 is a novel radioligand for localizing
#=GF RT   the APJ orphan receptor in human and rat tissues with evidence
#=GF RT   for a vasoconstrictor role in man.
#=GF RA   Katugampola SD, Maguire JJ, Matthewson SR, Davenport AP;
#=GF RL   Br J Pharmacol. 2001;132:1255-1260.
#=GF RN   [2]
#=GF RM   12963638
#=GF RT   Novel role for the potent endogenous inotrope apelin in human
#=GF RT   cardiac dysfunction.
#=GF RA   Chen MM, Ashley EA, Deng DX, Tsalenko A, Deng A, Tabibiazar R,
#=GF RA   Ben-Dor A, Fenster B, Yang E, King JY, Fowler M, Robbins R,
#=GF RA   Johnson FL, Bruhn L, McDonagh T, Dargie H, Yakhini Z, Tsao PS,
#=GF RA   Quertermous T;
#=GF RL   Circulation. 2003;108:1432-1439.
#=GF RN   [3]
#=GF RM   22842084
#=GF RT   Apelin inhibits adipogenesis and lipolysis through distinct
#=GF RT   molecular pathways.
#=GF RA   Than A, Cheng Y, Foh LC, Leow MK, Lim SC, Chuah YJ, Kang Y, Chen
#=GF RA   P;
#=GF RL   Mol Cell Endocrinol. 2012; [Epub ahead of print]
#=GF RN   [4]
#=GF RM   22895257
#=GF RT   INHIBITION OF APELIN EXPRESSION BY BMP SIGNALING IN ENDOTHELIAL
#=GF RT   CELLS.
#=GF RA   Poirier O, Ciumas M, Eyries M, Montagne K, Nadaud S, Soubrier F;
#=GF RL   Am J Physiol Cell Physiol. 2012; [Epub ahead of print]
#=GF DR   INTERPRO; IPR026155;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Apelin is among the most potent stimulators of cardiac
#=GF CC   contractility known. The apelin-APJ signaling pathway is an
#=GF CC   important novel mediator of cardiovascular control [1]. Apelin
#=GF CC   is an adipokine secreted by adipocytes where it is co-expressed
#=GF CC   with apelin receptor (APJ) in adipocytes.  It suppresses
#=GF CC   adipogenesis through MAPK kinase/ERK dependent pathways and
#=GF CC   prevents lipid droplet fragmentation, thereby inhibiting basal
#=GF CC   lipolysis through AMP kinase dependent enhancement of perilipin
#=GF CC   expression. It also inhibits hormone-stimulated acute lipolysis
#=GF CC   through decreasing perilipin phosphorylation. Apelin induces a
#=GF CC   decrease of free fatty acid release via its dual inhibition on
#=GF CC   adipogenesis and lipolysis [2]. As a vaso-active and vascular
#=GF CC   cell growth-regulating peptide Apelin is a target of the BMP
#=GF CC   pathway, the TGF-beta/bone morphogenic protein (BMP) system - a
#=GF CC   major pathway for angiogenesis [3].
#=GF SQ   93
#=GS F7EWH6_MONDO/151-204      AC F7EWH6.2
#=GS A0A3Q3GVJ4_9LABR/22-76    AC A0A3Q3GVJ4.1
#=GS A0A1S3SSH3_SALSA/23-78    AC A0A1S3SSH3.1
#=GS A0A2K6B2K3_MACNE/23-77    AC A0A2K6B2K3.1
#=GS A0A3P9BJI6_9CICH/22-76    AC A0A3P9BJI6.1
#=GS A0A452DJT3_BOVIN/136-190  AC A0A452DJT3.1
#=GS A0A3B4TQF3_SERDU/22-76    AC A0A3B4TQF3.1
#=GS W5NDT8_LEPOC/23-77        AC W5NDT8.1
#=GS G3U153_LOXAF/23-77        AC G3U153.1
#=GS A0A2Y9SZ03_PHYMC/23-77    AC A0A2Y9SZ03.1
#=GS APEL_HUMAN/23-77          AC Q9ULZ1.1
#=GS A0A3B4WPT3_SERLL/22-76    AC A0A3B4WPT3.1
#=GS G1TTT0_RABIT/23-77        AC G1TTT0.1
#=GS A1XP38_XENLA/23-76        AC A1XP38.1
#=GS A0A2Y9KMF0_ENHLU/23-77    AC A0A2Y9KMF0.1
#=GS A0A337S4B6_FELCA/23-77    AC A0A337S4B6.1
#=GS A0A2I2Z1U0_GORGO/23-77    AC A0A2I2Z1U0.1
#=GS A0A3Q3N3U9_9TELE/23-77    AC A0A3Q3N3U9.1
#=GS APEL_RAT/23-77            AC Q9R0R3.1
#=GS A0A2U3XUX6_LEPWE/19-73    AC A0A2U3XUX6.1
#=GS A0A3B5KED7_TAKRU/111-165  AC A0A3B5KED7.1
#=GS A0A3Q0S1L3_AMPCI/22-74    AC A0A3Q0S1L3.1
#=GS A0A3P8N9Z3_ASTCA/22-76    AC A0A3P8N9Z3.1
#=GS A0A3B4CSG2_PYGNA/23-77    AC A0A3B4CSG2.1
#=GS A0A3B3Z5S3_9TELE/22-74    AC A0A3B3Z5S3.1
#=GS A0A2D0RJ01_ICTPU/23-77    AC A0A2D0RJ01.1
#=GS A0A3P9AED5_ESOLU/22-77    AC A0A3P9AED5.1
#=GS W5PZT7_SHEEP/22-76        AC W5PZT7.1
#=GS A0A2K5IYX0_COLAP/23-77    AC A0A2K5IYX0.1
#=GS A0A3Q3W1A2_MOLML/22-76    AC A0A3Q3W1A2.1
#=GS A0A2U9CAC4_SCOMX/23-57    AC A0A2U9CAC4.1
#=GS A0A2K6EG20_PROCO/23-77    AC A0A2K6EG20.1
#=GS M4AGL4_XIPMA/22-74        AC M4AGL4.2
#=GS K7GLR4_PIG/22-76          AC K7GLR4.2
#=GS A0A2K6RR72_RHIRO/23-77    AC A0A2K6RR72.1
#=GS A0A3B3VYA3_9TELE/22-74    AC A0A3B3VYA3.1
#=GS A0A4D9DYI7_9SAUR/70-124   AC A0A4D9DYI7.1
#=GS A0A452EV17_CAPHI/12-66    AC A0A452EV17.1
#=GS A0A3Q2ZEC5_KRYMA/22-74    AC A0A3Q2ZEC5.1
#=GS APEL_MOUSE/23-77          AC Q9R0R4.1
#=GS A0A452EUY8_CAPHI/18-72    AC A0A452EUY8.1
#=GS A0A3Q4N6C1_NEOBR/22-76    AC A0A3Q4N6C1.1
#=GS A0A3Q7XFM5_URSAR/23-77    AC A0A3Q7XFM5.1
#=GS W5PZT6_SHEEP/28-82        AC W5PZT6.1
#=GS G1M9E8_AILME/23-77        AC G1M9E8.1
#=GS A0A493T7U4_ANAPP/25-76    AC A0A493T7U4.1
#=GS A0A1L7HA09_CHICK/24-78    AC A0A1L7HA09.1
#=GS APEL_BOVIN/23-77          AC Q9TUI9.1
#=GS A0A286XKG6_CAVPO/23-75    AC A0A286XKG6.1
#=GS A0A1U7SBI1_ALLSI/9-63     AC A0A1U7SBI1.1
#=GS A0A1S3FAK0_DIPOR/23-77    AC A0A1S3FAK0.1
#=GS A0A2R8MM11_CALJA/23-77    AC A0A2R8MM11.1
#=GS A0A3B3DN15_ORYME/22-76    AC A0A3B3DN15.1
#=GS A0A1U7R0D2_MESAU/23-77    AC A0A1U7R0D2.1
#=GS A0A3P8UVQ3_CYNSE/22-76    AC A0A3P8UVQ3.1
#=GS A0A1U7TII0_TARSY/23-77    AC A0A1U7TII0.1
#=GS A0A3P9P6G2_POERE/22-74    AC A0A3P9P6G2.1
#=GS A0A3Q2FIY1_CYPVA/22-74    AC A0A3Q2FIY1.1
#=GS A0A3B5AG61_9TELE/23-77    AC A0A3B5AG61.1
#=GS A0A2K5Y1Q5_MANLE/23-77    AC A0A2K5Y1Q5.1
#=GS A0A0D9R7Q2_CHLSB/23-77    AC A0A0D9R7Q2.1
#=GS A0A3Q7UL60_VULVU/70-124   AC A0A3Q7UL60.1
#=GS A0A452RG05_URSAM/17-71    AC A0A452RG05.1
#=GS A0A3B3IPB5_ORYLA/22-76    AC A0A3B3IPB5.1
#=GS A0A287A142_PIG/23-77      AC A0A287A142.1
#=GS A0A384CGN6_URSMA/24-78    AC A0A384CGN6.1
#=GS G1Q652_MYOLU/23-77        AC G1Q652.1
#=GS A0A2K5TJI6_MACFA/23-77    AC A0A2K5TJI6.1
#=GS A0A3Q3C5Y7_HAPBU/22-76    AC A0A3Q3C5Y7.1
#=GS A0A3B4AU25_9GOBI/22-76    AC A0A3B4AU25.1
#=GS A0A3P8S8N4_AMPPE/115-169  AC A0A3P8S8N4.1
#=GS A0A2K5QLE1_CEBCA/23-77    AC A0A2K5QLE1.1
#=GS A0A2I4AW38_9TELE/23-75    AC A0A2I4AW38.1
#=GS A0A287D3D8_ICTTR/23-75    AC A0A287D3D8.1
#=GS A9ULR5_XENTR/23-76        AC A9ULR5.1
#=GS A0A2U3VXS2_ODORO/23-77    AC A0A2U3VXS2.1
#=GS A0A452GLA3_9SAUR/24-75    AC A0A452GLA3.1
#=GS A0A3B4FX61_9CICH/22-76    AC A0A3B4FX61.1
#=GS A0A2K6KLP8_RHIBE/23-77    AC A0A2K6KLP8.1
#=GS APEL_DANRE/23-77          AC Q4TTN8.2
#=GS A0A3B3SUF1_9TELE/17-71    AC A0A3B3SUF1.1
#=GS A0A1S3A126_ERIEU/23-77    AC A0A1S3A126.1
#=GS A0A3B3QFA1_9TELE/2-54     AC A0A3B3QFA1.1
#=GS A0A3Q2HT60_HORSE/132-186  AC A0A3Q2HT60.1
#=GS A0A3Q1CW32_AMPOC/23-77    AC A0A3Q1CW32.1
#=GS A0A2Y9M6A9_DELLE/23-77    AC A0A2Y9M6A9.1
#=GS A0A498LPD1_LABRO/23-77    AC A0A498LPD1.1
#=GS A0A3Q1F0Z6_9TELE/22-76    AC A0A3Q1F0Z6.1
#=GS A0A2U4A1K6_TURTR/27-81    AC A0A2U4A1K6.1
#=GS A0A3B1J5L3_ASTMX/277-331  AC A0A3B1J5L3.1
#=GS A0A3Q1J130_ANATE/111-165  AC A0A3Q1J130.1
#=GS A0A3B4WMP6_SERLL/17-68    AC A0A3B4WMP6.1
#=GS A0A2K6TVK2_SAIBB/23-77    AC A0A2K6TVK2.1
F7EWH6_MONDO/151-204                 ......GPLVEPSDRKELEE.GNIRTLVQPKGARVG-GPWPGGRRKFRRQRPRLSHKGPMPF.
A0A3Q3GVJ4_9LABR/22-76               ......APMASTEHGRELEDaPIVRKMVQQNPARGGQTHRPAGWKR-RRPRPRLSNKGPMPF.
A0A1S3SSH3_SALSA/23-78               ...gpi--MASTEHGKALEEaGAVRRLVQQNPGRGGQSHRPAGWKR-RRPRPRLSHKGPMPF.
A0A2K6B2K3_MACNE/23-77               ......GPLMQLPYGNGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF.
A0A3P9BJI6_9CICH/22-76               ......APMASTVHGRELQDaSMVRKMVQQNSARGGQTHRPTSSKR-RRPRPRLSHKGPMPF.
A0A452DJT3_BOVIN/136-190             ......GPLLQTSDGKEMEE.GTIRYLVQPRGPRSGPGPWQGGRRKFRRQRPRLSHKGPMPF.
A0A3B4TQF3_SERDU/22-76               ......APMASMEHGRELEEaSTVRKMVQQSPARGGQTHRPAGWKR-RRPRPRLSHKGPMPF.
W5NDT8_LEPOC/23-77                   ......GPLASTEQSKDMEEgGSVRKLVQHSAARGGQSHRPAGWKR-RRPRPRLSHKGPMPF.
G3U153_LOXAF/23-77                   ......GPLMQPSERKGLEE.GNVRHLVQPRGVRNGPGPWQGGRRKFRRQRPRLSHKGPMPF.
A0A2Y9SZ03_PHYMC/23-77               ......GPLLQTSDGKGMEE.GTIRHLVQPRGPRSGPGPWQGGRRKFRRQRPRLSHKGPMPF.
APEL_HUMAN/23-77                     ....gs--LMPLPDGNGLED.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF.
A0A3B4WPT3_SERLL/22-76               ......APMASMEHGRELEEaSTVRKMVQQSPARGGQTHRPAGWKR-RRPRPRLSHKGPMPF.
G1TTT0_RABIT/23-77                   ......GPLGQPPQGNGLEE.GNVRYLLQPRAPRNGPGPWQGGRRKFRRQRPRLSHKGPMPF.
A1XP38_XENLA/23-76                   ......APLAEGSDRNDEEQ.-NIRTLVNPKMVRNSAPQRQANRRKLIRQRPRLSHKGPMPF.
A0A2Y9KMF0_ENHLU/23-77               ......GPLLQPADGKGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF.
A0A337S4B6_FELCA/23-77               ......GPLLQPSDGNGLEE.SNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF.
A0A2I2Z1U0_GORGO/23-77               ....gs--LMPLPDGNGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF.
A0A3Q3N3U9_9TELE/23-77               ......GPMASTEHGKELEEaATMRKMVQQNPARGGQTHRPAGFKR-RRPRPRLSHKGPMPF.
APEL_RAT/23-77                       ......VPLMLPPDGKGLEE.GNMRYLVKPRTSRTGPGAWQGGRRKFRRQRPRLSHKGPMPF.
A0A2U3XUX6_LEPWE/19-73               .....w-PLLQPSDGKGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF.
A0A3B5KED7_TAKRU/111-165             ......GPMASTEHGKELEEaATVRKMVQQNPARGGQTHRPAGWKR-RRPRPRLSHKGPMPF.
A0A3Q0S1L3_AMPCI/22-74               ......APMASTVHGRELQE.-TSRKMAQQNSARGGQTHRPSGLKR-RRPRPRLSHKGPMPF.
A0A3P8N9Z3_ASTCA/22-76               ......APMASTVHGRELQDaSMVRKMVQQNSARGGQTHRPTSSKR-RRPRPRLSHKGPMPF.
A0A3B4CSG2_PYGNA/23-77               ......GPMASTEHSKELEEvGSMRTPVRQNPARAGRSQRPSGWRR-RRPRPRLSHKGPMPF.
A0A3B3Z5S3_9TELE/22-74               ......APMASTEHGRGLEEaATVRKMAQQNPVRGGQTHRPA--KR-RRPRPRLSHKGPMPF.
A0A2D0RJ01_ICTPU/23-77               ......GPVTSTEHSKELEEvGSMRTPVRQNPARAGRNQRPSGWRR-RRPRPRLSHKGPMPF.
A0A3P9AED5_ESOLU/22-77               ...api--MASTEHGAVLEEaGGVRRVAQQNPGRGGQSHRPAGWKR-RRPRPRLSHKGPMPF.
W5PZT7_SHEEP/22-76                   ......GPLLQTSDGKEMEE.GTIRYLVQPRGARSGPGPWQGGRRKFRRQRPRLSHKGPMPF.
A0A2K5IYX0_COLAP/23-77               ......GPLMRLPYGNGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF.
A0A3Q3W1A2_MOLML/22-76               ......APMASTEHGRELEEvAPVRKMVQQNPARGGQTHRQAGWKR-RRPRPRLSHKGPMPF.
A0A2U9CAC4_SCOMX/23-57               ......GPMASVEHGRELEEaSAVRKMVQQSPARGGCCDR----------------------g
A0A2K6EG20_PROCO/23-77               ......GPLMQPPEGKGLEE.GKVRHLVQPRASRNGPGPWQGGRRKFRRQRPRLSHKGPMPF.
M4AGL4_XIPMA/22-74                   ......APMASTEHGRGLEEaATVRKMAQQNPVRGGQTHRPA--KR-RRPRPRLSHKGPMPF.
K7GLR4_PIG/22-76                     .....r-PLLQTSGGKGMEE.GNVRYLVQPRGPRSGPGPWQGGRRKFRRQRPRLSHKGPMPF.
A0A2K6RR72_RHIRO/23-77               ......GPLMQLPYGNGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF.
A0A3B3VYA3_9TELE/22-74               ......APMASTEHGRGLEEaATVRKMAQQNPVRGGQTHRPA--KR-RRPRPRLSHKGPMPF.
A0A4D9DYI7_9SAUR/70-124              ......APLAEAPDGRDLEK.GNIRNLVHPKGVRNGAGNRQNGWRKSRRPRPRLSHKGPMPF.
A0A452EV17_CAPHI/12-66               ......GPLLQTSDGKEMEE.GTIRYLVQPRGARSGPGPWQGGRRKFRRQRPRLSHKGPMPF.
A0A3Q2ZEC5_KRYMA/22-74               ......APMASTEHGRGLEEtATVRKMAQQNPVRGGQTHRPA--KR-RRPRPRLSHKGPMPF.
APEL_MOUSE/23-77                     ......VPLMLPPDGTGLEE.GSMRYLVKPRTSRTGPGAWQGGRRKFRRQRPRLSHKGPMPF.
A0A452EUY8_CAPHI/18-72               ......GPLLQTSDGKEMEE.GTIRYLVQPRGARSGPGPWQGGRRKFRRQRPRLSHKGPMPF.
A0A3Q4N6C1_NEOBR/22-76               ......APMASTVHGRELQDaSMVRKMVQQNSARGGQTHRPTSSKR-RRPRPRLSHKGPMPF.
A0A3Q7XFM5_URSAR/23-77               ......GPLLQPSDGKGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF.
W5PZT6_SHEEP/28-82                   ......GPLLQTSDGKEMEE.GTIRYLVQPRGARSGPGPWQGGRRKFRRQRPRLSHKGPMPF.
G1M9E8_AILME/23-77                   ......GPLLQPSDGTWLEE.GSVHHLMQPKGSRNRPGPWQGGRRKFRRQRPRLSHKSPMPF.
A0A493T7U4_ANAPP/25-76               ..gplp-------DGTGPQR.GRIRVLVRPRGARRGAGQRAGGWRRLRRPRPRLSHKGPMPF.
A0A1L7HA09_CHICK/24-78               ......GPLGAGLDGMDPED.GLIRTLVRPRGARRGNVRRPGGWRRLRRPRPRLSHKGPMPF.
APEL_BOVIN/23-77                     ......GPLLQTSDGKEMEE.GTIRYLVQPRGPRSGPGPWQGGRRKFRRQRPRLSHKGPMPF.
A0A286XKG6_CAVPO/23-75               ......VPLLQPPDGKGLEE.--VSYLVQPRASRNGPAPWQGGRRKFRRQRPRLSHKGPMPF.
A0A1U7SBI1_ALLSI/9-63                ......GPLAEAPDGKDPEE.GNIRNLVYPRGARNGAGHRQNGWRKYRRPRPRLSHKGPMPF.
A0A1S3FAK0_DIPOR/23-77               ......VPLMLPSDGNGMEE.GNLHYLVQPRASRNGPGTWQGGRRKFRRQRPRLSHKGPMPF.
A0A2R8MM11_CALJA/23-77               ......GPLMPLPDGNGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF.
A0A3B3DN15_ORYME/22-76               ......APMASTEHGKDLGEtATVRKMVQQNPPRGGQPQRPAGWKR-RRPRPRLSHKGPMPF.
A0A1U7R0D2_MESAU/23-77               ......VPLMLPSDGKGLEE.GNMRYLVQPRASRTGPGPWQGGRRKFRRQRPRLSHKGPMPF.
A0A3P8UVQ3_CYNSE/22-76               ......APMASVEHGREVEEaPTVRKMVQQSPARGGQPHRPAGWKR-RRPRPRLSHKVPMPF.
A0A1U7TII0_TARSY/23-77               ......GPLVQSPDGKGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSYKGPMPF.
A0A3P9P6G2_POERE/22-74               ......APMASTEHGRGLEEaATVRKMAQQNPVRGGQTHRPA--KR-RRPRPRLSHKGPMPF.
A0A3Q2FIY1_CYPVA/22-74               ......APMASTEHGRGLEGaNTVRKMAQQTPVRGGQTHRPS--KR-RRPRPRLSHKGPMPF.
A0A3B5AG61_9TELE/23-77               ......GPMASTEHGRELEEaATVRKMVQQNPARGGQTHRPAGWKR-RRPRPRLSHKGPMPF.
A0A2K5Y1Q5_MANLE/23-77               ......GPLMQLPYGNGLEE.GNVRHLVQPRGTRNGPGPWQGGRRKFRRQRPRLSHKGPMPF.
A0A0D9R7Q2_CHLSB/23-77               ......GPLMQLPYGNGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF.
A0A3Q7UL60_VULVU/70-124              .....w-PLLQPPDGKGLEE.GNIRHLVQPRGSRNGLGPWQGGRKKFRRQRPRLSHKGPMPF.
A0A452RG05_URSAM/17-71               ......GPLLQPSDGKGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF.
A0A3B3IPB5_ORYLA/22-76               ......APMASTEHGKDLGEtATVKKMVQQNPARGGQPQRPAGWKR-RRPRPRLSHKGPMPF.
A0A287A142_PIG/23-77                 ......GPLLQTSGGKGMEE.GNVRYLVQPRGPRSGPGPWQGGRRKFRRQRPRLSHKGPMPF.
A0A384CGN6_URSMA/24-78               .....r-PLLQPSDGKGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF.
G1Q652_MYOLU/23-77                   ......GPLPQPSAGKGLEE.GNIHHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF.
A0A2K5TJI6_MACFA/23-77               ......GPLMQLPYGNGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF.
A0A3Q3C5Y7_HAPBU/22-76               ......APMASTVHGRELQDaSMVRKMVQQNSARGGQTHRPTSSKR-RRPRPRLSHKGPMPF.
A0A3B4AU25_9GOBI/22-76               ......APMASTEHGRELEEtATVRKLVPPNPVRTGQSHRPAGWKR-RRPRPRLSHKGPMPF.
A0A3P8S8N4_AMPPE/115-169             ......GPMASTEHGRELEEaATVRKMVQQNPARGGQTHRPAGWKR-RRPRPRLSHKGPMPF.
A0A2K5QLE1_CEBCA/23-77               ......GPLMPLPDGNGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF.
A0A2I4AW38_9TELE/23-75               ......GPMASTEHGRGLEEtATVRKMAQQNPMRGGQTHRPA--KR-RRPRPRLSHKGPMPF.
A0A287D3D8_ICTTR/23-75               ......VPLMQPPDGKELEE.GNVRYLVQPRASRNG--PWQGGRRKFRRQRPRLSHKGPMPF.
A9ULR5_XENTR/23-76                   ......APLAEGSDRNDEEQ.-NIRTLVNPKMVRNPAPQRQANWRKIRRQRPRLSHKGPMPF.
A0A2U3VXS2_ODORO/23-77               ......GPLLRPSDGRGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF.
A0A452GLA3_9SAUR/24-75               ...hpa------PDGRDLEK.GNIRNLVHPKGVRNGAGHRQNGWRKSRRPRPRLSHKGPMPF.
A0A3B4FX61_9CICH/22-76               ......APMASTVHGRELQDaSMVRKMVQQNSARGGQTHRPTSSKR-RRPRPRLSHKGPMPF.
A0A2K6KLP8_RHIBE/23-77               ......GPLMRLPYGNGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF.
APEL_DANRE/23-77                     ......GPMASTEHSKEIEEvGSMRTPLRQNPARAGRSQRPAGWRR-RRPRPRLSHKGPMPF.
A0A3B3SUF1_9TELE/17-71               ......GPMATTDRAKELEKeGTVRKAGQQSPSRSSPSHRAGTWKR-RRTRPRLSHKGPMPF.
A0A1S3A126_ERIEU/23-77               ......GPVLQSGGRKGLQE.GSARHVAKPRGPRSGPGPWQGARKKLRRQRPRLSHKSPMPF.
A0A3B3QFA1_9TELE/2-54                ..lctk-----YEQGKGVDV.GNLRRLVQQSPARSAQSHRAAGWRR-RRPRPRLSHKGPMPF.
A0A3Q2HT60_HORSE/132-186             ......GPLLQPPDGQGLEE.GDVRYLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF.
A0A3Q1CW32_AMPOC/23-77               ......GPMASTEHGRELEEaATVRKMVQQNPARGGQTHRPAGWKR-RRPRPRLSHKGPMPF.
A0A2Y9M6A9_DELLE/23-77               ......GPLLQTSDGKGMEE.GTIRHLVQPRGPRSGPGPWQGGRRKFRRQRPRLSHKGPMPF.
A0A498LPD1_LABRO/23-77               ......GPMASTEHSKELEEvGSMRTPLRQNSARAGRSQRPSGWRR-RRPRPRLSHKGPMPF.
A0A3Q1F0Z6_9TELE/22-76               ......APMASTEHGRELEEgATVRKMVQQNPARGSQTHRPAGWKR-RRPRPRLSHKGPMPF.
A0A2U4A1K6_TURTR/27-81               ......GPLLQTSDGKGMEE.GTIRHLVQPRGPRSGPGPWQGGRRKFRRQRPRLSHKGPMPF.
A0A3B1J5L3_ASTMX/277-331             ......GPMASTEHSKELEEvGSMRTPLRQTQARAGRSQRPSSWRR-RRPRPRLSHKGPMPF.
A0A3Q1J130_ANATE/111-165             ......GPMASTEHGRELEEaTSVRKMVQQNTARGGQTHRPAGWKR-RRPRPRLSHKGPMPF.
A0A3B4WMP6_SERLL/17-68               llhifh---------NQLEEaSTVRKMVQQSPARGGQTHRPAGWKR-RRPRPRLSHKGPMPF.
A0A2K6TVK2_SAIBB/23-77               ......GPLMPLPDGNGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF.
#=GC seq_cons                        ......uPhhpsscG+sLEE.GsVR+LVQ.puuRsG.u.h.uGhR+.RR.RPRLSHKGPMPF.
//
DBGET integrated database retrieval system