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Database: Pfam
Entry: Apelin
LinkDB: Apelin
Original site: Apelin 
#=GF ID   Apelin
#=GF AC   PF15360.6
#=GF DE   APJ endogenous ligand
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   Jackhmmer:Q9ULZ1
#=GF GA   27.00 27.00;
#=GF TC   77.20 77.00;
#=GF NC   22.10 21.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   11250876
#=GF RT   [(125)I]-(Pyr(1))Apelin-13 is a novel radioligand for localizing
#=GF RT   the APJ orphan receptor in human and rat tissues with evidence
#=GF RT   for a vasoconstrictor role in man.
#=GF RA   Katugampola SD, Maguire JJ, Matthewson SR, Davenport AP;
#=GF RL   Br J Pharmacol. 2001;132:1255-1260.
#=GF RN   [2]
#=GF RM   12963638
#=GF RT   Novel role for the potent endogenous inotrope apelin in human
#=GF RT   cardiac dysfunction.
#=GF RA   Chen MM, Ashley EA, Deng DX, Tsalenko A, Deng A, Tabibiazar R,
#=GF RA   Ben-Dor A, Fenster B, Yang E, King JY, Fowler M, Robbins R,
#=GF RA   Johnson FL, Bruhn L, McDonagh T, Dargie H, Yakhini Z, Tsao PS,
#=GF RA   Quertermous T;
#=GF RL   Circulation. 2003;108:1432-1439.
#=GF RN   [3]
#=GF RM   22842084
#=GF RT   Apelin inhibits adipogenesis and lipolysis through distinct
#=GF RT   molecular pathways.
#=GF RA   Than A, Cheng Y, Foh LC, Leow MK, Lim SC, Chuah YJ, Kang Y, Chen
#=GF RA   P;
#=GF RL   Mol Cell Endocrinol. 2012; [Epub ahead of print]
#=GF RN   [4]
#=GF RM   22895257
#=GF RT   INHIBITION OF APELIN EXPRESSION BY BMP SIGNALING IN ENDOTHELIAL
#=GF RT   CELLS.
#=GF RA   Poirier O, Ciumas M, Eyries M, Montagne K, Nadaud S, Soubrier F;
#=GF RL   Am J Physiol Cell Physiol. 2012; [Epub ahead of print]
#=GF DR   INTERPRO; IPR026155;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Apelin is among the most potent stimulators of cardiac
#=GF CC   contractility known. The apelin-APJ signaling pathway is an
#=GF CC   important novel mediator of cardiovascular control [1]. Apelin
#=GF CC   is an adipokine secreted by adipocytes where it is co-expressed
#=GF CC   with apelin receptor (APJ) in adipocytes.  It suppresses
#=GF CC   adipogenesis through MAPK kinase/ERK dependent pathways and
#=GF CC   prevents lipid droplet fragmentation, thereby inhibiting basal
#=GF CC   lipolysis through AMP kinase dependent enhancement of perilipin
#=GF CC   expression. It also inhibits hormone-stimulated acute lipolysis
#=GF CC   through decreasing perilipin phosphorylation. Apelin induces a
#=GF CC   decrease of free fatty acid release via its dual inhibition on
#=GF CC   adipogenesis and lipolysis [2]. As a vaso-active and vascular
#=GF CC   cell growth-regulating peptide Apelin is a target of the BMP
#=GF CC   pathway, the TGF-beta/bone morphogenic protein (BMP) system - a
#=GF CC   major pathway for angiogenesis [3].
#=GF SQ   32
#=GS F7EWH6_MONDO/151-204    AC F7EWH6.2
#=GS APEL_MOUSE/23-77        AC Q9R0R4.1
#=GS A0A1S3SSH3_SALSA/23-78  AC A0A1S3SSH3.1
#=GS W5PZT6_SHEEP/28-82      AC W5PZT6.1
#=GS G1M9E8_AILME/23-77      AC G1M9E8.1
#=GS W5NDT8_LEPOC/23-77      AC W5NDT8.1
#=GS G3U153_LOXAF/23-77      AC G3U153.1
#=GS APEL_HUMAN/23-77        AC Q9ULZ1.1
#=GS APEL_BOVIN/23-77        AC Q9TUI9.1
#=GS A0A286XKG6_CAVPO/23-75  AC A0A286XKG6.1
#=GS A0A1S3FAK0_DIPOR/23-77  AC A0A1S3FAK0.1
#=GS A0A1U7SBI1_ALLSI/9-63   AC A0A1U7SBI1.1
#=GS G1TTT0_RABIT/23-77      AC G1TTT0.1
#=GS A0A1U7R0D2_MESAU/23-77  AC A0A1U7R0D2.1
#=GS W5JY37_ASTMX/23-77      AC W5JY37.1
#=GS A1XP38_XENLA/23-76      AC A1XP38.1
#=GS M4AGL4_XIPMA/23-75      AC M4AGL4.1
#=GS A0A1U7TII0_TARSY/23-77  AC A0A1U7TII0.1
#=GS A0A0D9R7Q2_CHLSB/23-77  AC A0A0D9R7Q2.1
#=GS A0A2I2Z1U0_GORGO/23-77  AC A0A2I2Z1U0.1
#=GS A0A287A142_PIG/23-77    AC A0A287A142.1
#=GS G1Q652_MYOLU/23-77      AC G1Q652.1
#=GS APEL_RAT/23-77          AC Q9R0R3.1
#=GS A0A2I4AW38_9TELE/23-75  AC A0A2I4AW38.1
#=GS A0A287D3D8_ICTTR/23-75  AC A0A287D3D8.1
#=GS A9ULR5_XENTR/23-76      AC A9ULR5.1
#=GS APEL_DANRE/23-77        AC Q4TTN8.2
#=GS A0A1S3A126_ERIEU/23-77  AC A0A1S3A126.1
#=GS A0A2D0RJ01_ICTPU/23-77  AC A0A2D0RJ01.1
#=GS W5PZT7_SHEEP/22-76      AC W5PZT7.1
#=GS A0A2K5IYX0_COLAP/23-77  AC A0A2K5IYX0.1
#=GS K7GLR4_PIG/22-76        AC K7GLR4.2
F7EWH6_MONDO/151-204               ...GPLVEPSDRKELEE.GNIRTLVQPKGARVG-GPWPGGRRKFRRQRPRLSHKGPMPF
APEL_MOUSE/23-77                   ...VPLMLPPDGTGLEE.GSMRYLVKPRTSRTGPGAWQGGRRKFRRQRPRLSHKGPMPF
A0A1S3SSH3_SALSA/23-78             gpi--MASTEHGKALEEaGAVRRLVQQNPGRGGQSHRPAGWKR-RRPRPRLSHKGPMPF
W5PZT6_SHEEP/28-82                 ...GPLLQTSDGKEMEE.GTIRYLVQPRGARSGPGPWQGGRRKFRRQRPRLSHKGPMPF
G1M9E8_AILME/23-77                 ...GPLLQPSDGTWLEE.GSVHHLMQPKGSRNRPGPWQGGRRKFRRQRPRLSHKSPMPF
W5NDT8_LEPOC/23-77                 ...GPLASTEQSKDMEEgGSVRKLVQHSAARGGQSHRPAGWKR-RRPRPRLSHKGPMPF
G3U153_LOXAF/23-77                 ...GPLMQPSERKGLEE.GNVRHLVQPRGVRNGPGPWQGGRRKFRRQRPRLSHKGPMPF
APEL_HUMAN/23-77                   .gs--LMPLPDGNGLED.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF
APEL_BOVIN/23-77                   ...GPLLQTSDGKEMEE.GTIRYLVQPRGPRSGPGPWQGGRRKFRRQRPRLSHKGPMPF
A0A286XKG6_CAVPO/23-75             ...VPLLQPPDGKGLEE.--VSYLVQPRASRNGPAPWQGGRRKFRRQRPRLSHKGPMPF
A0A1S3FAK0_DIPOR/23-77             ...VPLMLPSDGNGMEE.GNLHYLVQPRASRNGPGTWQGGRRKFRRQRPRLSHKGPMPF
A0A1U7SBI1_ALLSI/9-63              ...GPLAEAPDGKDPEE.GNIRNLVYPRGARNGAGHRQNGWRKYRRPRPRLSHKGPMPF
G1TTT0_RABIT/23-77                 ...GPLGQPPQGNGLEE.GNVRYLLQPRAPRNGPGPWQGGRRKFRRQRPRLSHKGPMPF
A0A1U7R0D2_MESAU/23-77             ...VPLMLPSDGKGLEE.GNMRYLVQPRASRTGPGPWQGGRRKFRRQRPRLSHKGPMPF
W5JY37_ASTMX/23-77                 ...GPMTSTEHSKELEEvGSMRTPLRQTQARAGRSQRPSSWRR-RRPRPRLSHKGPMPF
A1XP38_XENLA/23-76                 ...APLAEGSDRNDEEQ.-NIRTLVNPKMVRNSAPQRQANRRKLIRQRPRLSHKGPMPF
M4AGL4_XIPMA/23-75                 ...GPMASTEHGRGLEEaATVRKMAQQNPVRGGQTHRPA--KR-RRPRPRLSHKGPMPF
A0A1U7TII0_TARSY/23-77             ...GPLVQSPDGKGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSYKGPMPF
A0A0D9R7Q2_CHLSB/23-77             ...GPLMQLPYGNGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF
A0A2I2Z1U0_GORGO/23-77             .gs--LMPLPDGNGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF
A0A287A142_PIG/23-77               ...GPLLQTSGGKGMEE.GNVRYLVQPRGPRSGPGPWQGGRRKFRRQRPRLSHKGPMPF
G1Q652_MYOLU/23-77                 ...GPLPQPSAGKGLEE.GNIHHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF
APEL_RAT/23-77                     ...VPLMLPPDGKGLEE.GNMRYLVKPRTSRTGPGAWQGGRRKFRRQRPRLSHKGPMPF
A0A2I4AW38_9TELE/23-75             ...GPMASTEHGRGLEEtATVRKMAQQNPMRGGQTHRPA--KR-RRPRPRLSHKGPMPF
A0A287D3D8_ICTTR/23-75             ...VPLMQPPDGKELEE.GNVRYLVQPRASRNG--PWQGGRRKFRRQRPRLSHKGPMPF
A9ULR5_XENTR/23-76                 ...APLAEGSDRNDEEQ.-NIRTLVNPKMVRNPAPQRQANWRKIRRQRPRLSHKGPMPF
APEL_DANRE/23-77                   ...GPMASTEHSKEIEEvGSMRTPLRQNPARAGRSQRPAGWRR-RRPRPRLSHKGPMPF
A0A1S3A126_ERIEU/23-77             ...GPVLQSGGRKGLQE.GSARHVAKPRGPRSGPGPWQGARKKLRRQRPRLSHKSPMPF
A0A2D0RJ01_ICTPU/23-77             ...GPVTSTEHSKELEEvGSMRTPVRQNPARAGRNQRPSGWRR-RRPRPRLSHKGPMPF
W5PZT7_SHEEP/22-76                 ...GPLLQTSDGKEMEE.GTIRYLVQPRGARSGPGPWQGGRRKFRRQRPRLSHKGPMPF
A0A2K5IYX0_COLAP/23-77             ...GPLMRLPYGNGLEE.GNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF
K7GLR4_PIG/22-76                   ..r-PLLQTSGGKGMEE.GNVRYLVQPRGPRSGPGPWQGGRRKFRRQRPRLSHKGPMPF
#=GC seq_cons                      ...GPLhpsscGKsLEE.GslRaLVQPRuuRsGPGsWQGGRRKFRRQRPRLSHKGPMPF
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