GenomeNet

Database: Pfam
Entry: Apis_Csd
LinkDB: Apis_Csd
Original site: Apis_Csd 
#=GF ID   Apis_Csd
#=GF AC   PF11671.9
#=GF DE   Complementary sex determiner protein
#=GF AU   Pollington J;0000-0002-8158-8998
#=GF SE   Pfam-B_4678 (release 23.0)
#=GF GA   25.00 25.00;
#=GF TC   27.30 27.30;
#=GF NC   24.80 24.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   12941271
#=GF RT   The gene csd is the primary signal for sexual development in the
#=GF RT   honeybee and encodes an SR-type protein. 
#=GF RA   Beye M, Hasselmann M, Fondrk MK, Page RE, Omholt SW; 
#=GF RL   Cell. 2003;114:419-429.
#=GF RN   [2]
#=GF RM   15382141
#=GF RT   The dice of fate: the csd gene and how its allelic composition
#=GF RT   regulates sexual development in the honey bee, Apis mellifera. 
#=GF RA   Beye M; 
#=GF RL   Bioessays. 2004;26:1131-1139.
#=GF DR   INTERPRO; IPR021007;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family of proteins represents the complementary sex
#=GF CC   determiner in the honeybee. In the honeybee, the mechanism of
#=GF CC   sex determination depends on the csd gene which produces an
#=GF CC   SR-type protein. Males are homozygous while females are
#=GF CC   homozygous for the csd gene. Heterozygosity generates an active
#=GF CC   protein which initiates female development [2].
#=GF SQ   24
#=GS A0A2A3E9M7_APICC/373-464  AC A0A2A3E9M7.1
#=GS A0A088A6R5_APIME/452-598  AC A0A088A6R5.1
#=GS A0A154P620_DUFNO/343-417  AC A0A154P620.1
#=GS A0A0L7QPI6_9HYME/531-605  AC A0A0L7QPI6.1
#=GS A0A158NJA2_ATTCE/288-435  AC A0A158NJA2.1
#=GS A0A195D3I5_9HYME/291-446  AC A0A195D3I5.1
#=GS A0A195BLF4_9HYME/219-361  AC A0A195BLF4.1
#=GS A0A232EG63_9HYME/321-399  AC A0A232EG63.1
#=GS A0A158NJA0_ATTCE/281-429  AC A0A158NJA0.1
#=GS A0A195BLF4_9HYME/657-802  AC A0A195BLF4.1
#=GS F4WWP5_ACREC/287-435      AC F4WWP5.1
#=GS A0A2A3E9M7_APICC/308-379  AC A0A2A3E9M7.1
#=GS A0A026WXG5_OOCBI/291-427  AC A0A026WXG5.1
#=GS E1ZWU4_CAMFO/191-267      AC E1ZWU4.1
#=GS A0A0L7QPI6_9HYME/352-426  AC A0A0L7QPI6.1
#=GS A0A2A3EB46_APICC/1-36     AC A0A2A3EB46.1
#=GS A0A088A6R3_APIME/225-276  AC A0A088A6R3.1
#=GS E2C628_HARSA/62-139       AC E2C628.1
#=GS E1ZWU2_CAMFO/358-500      AC E1ZWU2.1
#=GS A0A088A6R5_APIME/267-422  AC A0A088A6R5.1
#=GS E2BCX3_HARSA/69-143       AC E2BCX3.1
#=GS B3VN92_NASVI/329-405      AC B3VN92.1
#=GS A0A0N0U378_9HYME/359-430  AC A0A0N0U378.1
#=GS A0A088A6R3_APIME/274-343  AC A0A088A6R3.1
A0A2A3E9M7_APICC/373-464             .............----------------..--....-------.------------.----------------.N.........NNNYNNYNNNYNNYN..NKKLY.YCNINYIEQ..IP..VPVYYG.NFPPNPIMVRPWVP.M.QEQIP....R.F...R.Y...IGPLT.SFPPRFIPP.NMYR-.RP.P.LNPRFRPMY......
A0A088A6R5_APIME/452-598             .............TSRNRYSRSREREQNS..YK....NEREYQK.YRETSKERSRDR.TERERCKEPKIISSLS.N.........NYKYSNYNNYNNNYN.tNYKKLqYYNIINIEQ..IPvpVPIYCG.NFPPRPM--GPWIS.I.QEQVP....R.F...R.Y...IGPPT.PF-PRFIPP.NAYRF.RP.P.LNPRFGPTH......
A0A154P620_DUFNO/343-417             ...........pp----------------..--....-------.------------.----------------.-.........---------------..-----.----HYIEQ..IP..VPIYYG.NFPPRPILMGPLIP.I.RGQMPl..rG.G...R.HpsmMAPIR.PFPPRFISS.DVYRL.RP.P.SNPRFGPMF......
A0A0L7QPI6_9HYME/531-605             ..........pap----------------..--....-------.------------.----------------.-.........---------------..-----.-----YIEQ..IP..VPIYYG.NFAPGPVMVGPLVP.I.RGQVPl..gG.N...R.HpsmMGPLR.LFPPRFISP.DMYRL.PP.P.LNPRFGPRY......
A0A158NJA2_ATTCE/288-435             ......ankhdnn-----RSRSRERNSYSrpFI....EERSYRDrYRERSNERSYER.RDRDRERNRE----RD.R.........NRD-----RTKTRDR..SRERR.DIAPHYIES.pIP..VPIYYG.SFPPRPIVVSPMVP.L.RGQIPp.mgR.G...R.HptlMAQVR.PFPPRF-PP.DMYRLgHP.P.PNPRYGP--f.....
A0A195D3I5_9HYME/291-446             ..........ntn--RSRSRESRNSHSRP..FI....EERSYRDrYRERSNERSYER.RDRDRGRDRDRDRDRErD.........RERDRNRDRTKDRNR..SRERR.DIAPHYIES.pIP..VPIYYG.SFPPRPIVVSPMVP.L.RGQIPp.mgR.G...R.HptlMAPVR.PFPPRF-PP.DIYRLgHP.P.PNPIMNPI-r.....
A0A195BLF4_9HYME/219-361             dktekcdtrkddg---------------P..FI....EERSYRDrYRERSNERSYER.RDRDRERNRE----RD.R.........NRD-----RTKTRDR..SRERR.DIAPHYIES.pIP..VPIYYG.SFPPRPIVVSPMVP.L.RGQIPp.mgR.G...R.HptlMAQVR.PFPPRF-PP.DMYRLgHP.P.PNPTMNPM-r.....
A0A232EG63_9HYME/321-399             .........rlpp----------------..--....-------.------------.----------------.-.........---------------..-----.---VQYVEQ..VP..YPVYYSaGFAPRPMLVGPAIPpL.RGPLA....GrG...RpL...MAPIRpPFPPRFIGPqDMFRA.VL.P.SDPRFGRMF......
A0A158NJA0_ATTCE/281-429             ......ankhdnn-----RSRSRERNSHSrpFI....EERSYRDrYREKSNECSYER.RDRERERNRERGRN--.-.........-RDRTK-----TRDR..SRERR.NIASRYIES.pIS..VPICYG.SFPPRPIVVNPMVP.L.RGQIS....S.MgrgR.HptlMVPVR.PFPPRF-PP.NMYSLgHS.S.PNP------ivslif
A0A195BLF4_9HYME/657-802             .....gankhdnn-----RSRSRERNSHSrpFI....EERSYRDrYREKSNERSYER.RDRERERNRERGRN--.-.........-RDRTK-----TRDR..SRERR.NIASRYIES.pIS..VPICYG.SFPPRPIVVNPMVP.L.RGQIS....S.MgrgR.HptlMVPVR.PFPPRF-PP.NMYSLgHP.S.PNP------sk....
F4WWP5_ACREC/287-435                 ....gankhdnnr----SHSRERNSHSRP..FI....EERSYRDrYRERSNERSYER.RDRDRERNRER-----.-.........---DRNRERTKTRDR..SRERR.DITPRYIES.pIP..VPIYYG.SFPPRPIVVGPMVP.L.RGQIPp.mgR.G...R.HptlMAQVR.PFPPRF-PP.DIYRLgHP.P.PNPRYGP--f.....
A0A2A3E9M7_APICC/308-379             .............TSRKRYSRSREREQKS..YK....NENSYRE.YRETSRERSRDR.REREKSREHKITSSLS.N.........NYNYNNYNNNYNNNN..-YN--.---------..--..------.--------------.-.-----....-.-...-.-...-----.---------.-----.--.-.---------n.....
A0A026WXG5_OOCBI/291-427             ............a-SKRNINRSRSRERDS..HSrqcmEEKPYRDrYYDRSSERSHER.RERERDRNRN------.-.........---KRE---SRS---..-RERR.DLTPHYIEP..VH..VPIYYS.NFP-RPIVVSPMVP.V.RGQIPp.mgR.G...R.H..lMAPVR.PFSPRFVPP.DMYRF.GP.P.PNPRYGPMF......
E1ZWU4_CAMFO/191-267                 ..........vas----------------..--....-------.------------.----------------.-.........---------------..-----.----HYIEP.pIH..VPIYY-.NLPPRPIVVSPMVP.F.RGQVPp.maR.G...R.HsalMAPVR.PFPPRFIPP.DMYRL.GPpP.PNPRYGP--f.....
A0A0L7QPI6_9HYME/352-426             ..........ppa----------------..--....-------.------------.----------------.-.........---------------..-----.----HYIEP..IP..VPIYYG.NFPPRPIMVGPLVP.I.RGQVPlggnR.H...P.M...MGPLR.PFPPRFISP.DMYRL.RA.P.PNPS-----iyehl.
A0A2A3EB46_APICC/1-36                .............----------------..--....-------.------------.----------------.-.........---------------..-----.---------..--..------.--------------.M.RGQVP....G.Y...R.H...IGP--.SFPPQFITR.NR---.NP.P.PNPRFRPIF......
A0A088A6R3_APIME/225-276             .............TSRRRYSRSREREQKS..YK....NEREYRE.YRETSRERSRDR.RERGRSREHRIIPS--.-.........---------------..-----.---------..--..------.--------------.-.-----....-.-...-.-...-----.---------.-----.--.-.---------h.....
E2C628_HARSA/62-139                  ..qhhimlntyqc----------------..--....-------.------------.----------------.-.........---------------..-----.---------..--..--LFIM.NFPPRPYMVSPMVT.IpRGQVPp.lgR.G...R.HpplMGPVR.PFPPRFVPP.DIYRM.GP.PaPNPRYGPMF......
E1ZWU2_CAMFO/358-500                 ..........dsd--------------RS..RK....RRRDKDR.DRDKSRERRRDRdRDRDRSRERKDVAPHY.V.........EPPIHVPDRDRDRDK..SKERK.DVAPHYVES.pIH..VPIYY-.NLPPSPIVVSPMVP.F.RGQVPp.maR.G...R.HsalMAPVR.PFPPWFIPP.DMYRL.RP.PpPNP------skyryy
A0A088A6R5_APIME/267-422             .............TSRKRYSRSREREQKS..YK....NENSYRK.YRETSKERSRDR.TERERSKEPKIISSLS.NktihnnnkyNYNKYNYNNNYNNNNynNYKKL.YYNINYIEQipIP..VPVYYG.NFPPRPM--GPWIS.I.QEQIP....R.F...R.H...IGPST.PF-PRFIPP.NAYRF.RP.P.LNPSM----ersc..
E2BCX3_HARSA/69-143                  .eiqchimlnmhq----------------..--....-------.------------.----------------.-.........---------------..-----.---------..--..-CLFIM.NLPPGPIMISPMVT.IpRRQVPp.lgR.S...Q.HpplMGLTR.PFPPRFIAP.DMYRI.RS.P.A--------pnss..
B3VN92_NASVI/329-405                 ...........pp----------------..--....-------.------------.----------------.-.........---------------..-----.---VQYIEQ..VP..FPIYYSaGFAPRPMLVGPAIPpI.RGPLA....GrG...RpL...MAPIRpPFPPRFIGPqDMYRA.GL.P.SDPRFGQMY......
A0A0N0U378_9HYME/359-430             ...........ss----------------..--....-------.------------.----------------.-.........---------------..-----.----HYIEQ..IT..VPFYYG.DFPARPIMVGPLVP.I.RGQVP...lG.P...R.H..mMGPLR.PFPPRFIPP.DMYRL.RP.P.LNPRFGPMY......
A0A088A6R3_APIME/274-343             ...........ps----------------..--....-------.------------.----------------.-.........---------------..-----.----HYIEQ..IP..VPVYYG.NFPPRPIMVRPWVP.M.RGQVP....G.S...R.H...IGPLT.PFPPRFIPP.DMYRL.RP.P.PNPRFGPMY......
#=GC seq_cons                        ...........ss...................................................................................................pYIEp..Is..VPlYYu.sFPPRPIhVuPhVP.l.RGQlP....p.s...R.H...MuPlR.PFPPRFlPP.DMYRh.+P.P.sNPpht.........
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