GenomeNet

Database: Pfam
Entry: Apo-CIII
LinkDB: Apo-CIII
Original site: Apo-CIII 
#=GF ID   Apo-CIII
#=GF AC   PF05778.13
#=GF DE   Apolipoprotein CIII (Apo-CIII)
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_7283 (release 8.0)
#=GF GA   34.10 34.10;
#=GF TC   34.70 34.30;
#=GF NC   33.40 34.00;
#=GF BM   hmmbuild --amino HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Apolipoprotein_C3
#=GF RN   [1]
#=GF RM   12082170
#=GF RT   Lipid-interacting properties of the N-terminal domain of human
#=GF RT   apolipoprotein C-III. 
#=GF RA   Lins L, Flore C, Chapelle L, Talmud PJ, Thomas A, Brasseur R; 
#=GF RL   Protein Eng 2002;15:513-520.
#=GF DR   INTERPRO; IPR008403;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of several mammalian apolipoprotein CIII
#=GF CC   (Apo-CIII) sequences. Apolipoprotein C-III is a 79-residue
#=GF CC   glycoprotein. It is synthesised in the intestine and liver as
#=GF CC   part of the very low density lipoprotein (VLDL) and the high
#=GF CC   density lipoprotein (HDL) particles. Owing to its positive
#=GF CC   correlation with plasma triglyceride (Tg) levels, Apo-CIII is
#=GF CC   suggested to play a role in Tg metabolism and is therefore of
#=GF CC   interest regarding atherosclerosis. However, unlike other
#=GF CC   apolipoproteins such as Apo-AI, Apo E or CII for which many
#=GF CC   naturally occurring mutations are known, the structure-function
#=GF CC   relationships of apo C-III remains a subject of debate. One
#=GF CC   possibility is that apo C-III inhibits lipoprotein lipase (LPL)
#=GF CC   activity, as shown by in vitro experiments. Another suggestion,
#=GF CC   is that elevated levels of Apo-CIII displace other
#=GF CC   apolipoproteins at the lipoprotein surface, modifying their
#=GF CC   clearance from plasma [1].
#=GF SQ   83
#=GS D3YXN8_MOUSE/22-53       AC D3YXN8.1
#=GS A0A0R4J1N3_MOUSE/22-90   AC A0A0R4J1N3.1
#=GS A0A096NCP4_PAPAN/40-108  AC A0A096NCP4.2
#=GS A0A2K6U3D9_SAIBB/22-90   AC A0A2K6U3D9.1
#=GS A0A2U3YIH1_LEPWE/22-90   AC A0A2U3YIH1.1
#=GS A0A1A6H7W0_NEOLE/22-90   AC A0A1A6H7W0.1
#=GS APOC3_HUMAN/22-90        AC P02656.1
#=GS APOC3_HUMAN/22-90        DR PDB; 2JQ3 A; 2-70;
#=GS A0A1S3EMA4_DIPOR/17-85   AC A0A1S3EMA4.1
#=GS APOC3_MOUSE/22-90        AC P33622.2
#=GS A0A2R8ZG19_PANPA/22-90   AC A0A2R8ZG19.1
#=GS E9QP56_MOUSE/60-128      AC E9QP56.1
#=GS APOC3_CAVPO/22-90        AC Q9Z2R5.1
#=GS G3QY94_GORGO/22-90       AC G3QY94.1
#=GS A0A2K5P9G2_CEBCA/40-108  AC A0A2K5P9G2.1
#=GS A0A2K5P467_CERAT/22-90   AC A0A2K5P467.1
#=GS A0A2U3X0U6_ODORO/22-90   AC A0A2U3X0U6.1
#=GS A0A2U4BWI3_TURTR/22-63   AC A0A2U4BWI3.1
#=GS APOC3_HETGA/22-96        AC G5BQH4.2
#=GS A0A2K5XUF4_MANLE/40-108  AC A0A2K5XUF4.1
#=GS A0A384C068_URSMA/22-90   AC A0A384C068.1
#=GS F1PDJ0_CANLF/22-90       AC F1PDJ0.1
#=GS L5KKQ2_PTEAL/22-90       AC L5KKQ2.1
#=GS A0A2K6RCA4_RHIRO/22-90   AC A0A2K6RCA4.1
#=GS A0A2K6FT92_PROCO/39-107  AC A0A2K6FT92.1
#=GS A0A1S3EL15_DIPOR/22-90   AC A0A1S3EL15.1
#=GS A0A452S109_URSAM/22-90   AC A0A452S109.1
#=GS A0A2Y9F8Y7_PHYMC/22-90   AC A0A2Y9F8Y7.1
#=GS F7FXR5_CALJA/40-108      AC F7FXR5.2
#=GS A0A0D9S396_CHLSB/22-90   AC A0A0D9S396.1
#=GS APOC3_MACFA/22-90        AC P18659.2
#=GS A0A452EAP5_CAPHI/25-83   AC A0A452EAP5.1
#=GS G1LPY8_AILME/22-90       AC G1LPY8.1
#=GS A0A091DKU6_FUKDA/22-94   AC A0A091DKU6.1
#=GS APOC3_BOVIN/22-90        AC P19035.2
#=GS A0A3Q7W9E7_URSAR/22-90   AC A0A3Q7W9E7.1
#=GS A0A1U7TCH1_TARSY/22-84   AC A0A1U7TCH1.1
#=GS A0A340XP38_LIPVE/22-90   AC A0A340XP38.1
#=GS G1R6X4_NOMLE/22-90       AC G1R6X4.3
#=GS A0A2K6U3D7_SAIBB/40-108  AC A0A2K6U3D7.1
#=GS A0A3Q7S6U0_VULVU/22-90   AC A0A3Q7S6U0.1
#=GS G3UIL9_LOXAF/26-99       AC G3UIL9.1
#=GS A0A3L8S109_CHLGU/24-92   AC A0A3L8S109.1
#=GS H0X1N8_OTOGA/22-90       AC H0X1N8.1
#=GS G1QA13_MYOLU/22-87       AC G1QA13.1
#=GS W5NWX6_SHEEP/36-104      AC W5NWX6.1
#=GS I3NEQ1_ICTTR/52-120      AC I3NEQ1.2
#=GS A0A2Y9K660_ENHLU/22-90   AC A0A2Y9K660.1
#=GS A0A1D5PK48_CHICK/24-92   AC A0A1D5PK48.1
#=GS C9J2Q0_HUMAN/22-55       AC C9J2Q0.1
#=GS A0A0G2K8Q1_RAT/22-90     AC A0A0G2K8Q1.1
#=GS APOC3_RAT/22-91          AC P06759.2
#=GS F7FQN1_MACMU/40-108      AC F7FQN1.2
#=GS A0A2K5HQ06_COLAP/40-108  AC A0A2K5HQ06.1
#=GS F6TE12_MONDO/21-89       AC F6TE12.1
#=GS G3WJF0_SARHA/24-92       AC G3WJF0.1
#=GS A0A3Q2I0V8_HORSE/21-89   AC A0A3Q2I0V8.1
#=GS A0A1U7S774_ALLSI/23-83   AC A0A1U7S774.1
#=GS B0YIW2_HUMAN/40-108      AC B0YIW2.1
#=GS A0A2K6JP04_RHIBE/22-90   AC A0A2K6JP04.1
#=GS G3I7Q2_CRIGR/22-70       AC G3I7Q2.1
#=GS A0A2Y9LYW0_DELLE/22-90   AC A0A2Y9LYW0.1
#=GS A0A218UQL8_9PASE/24-92   AC A0A218UQL8.1
#=GS H2R4Y3_PANTR/22-90       AC H2R4Y3.2
#=GS M3WSC8_FELCA/22-90       AC M3WSC8.1
#=GS A0A452HG41_9SAUR/64-132  AC A0A452HG41.1
#=GS A0A1U7QK70_MESAU/22-90   AC A0A1U7QK70.1
#=GS A0A2K6E8F3_MACNE/22-90   AC A0A2K6E8F3.1
#=GS M3XYL6_MUSPF/22-90       AC M3XYL6.1
#=GS APOC3_HORSE/20-88        AC P0DN28.1
#=GS A0A452EM11_CAPHI/22-90   AC A0A452EM11.1
#=GS A0A0Q3T1Q2_AMAAE/25-92   AC A0A0Q3T1Q2.1
#=GS APOC3_PIG/22-90          AC P27917.2
#=GS A0A3M0ITH7_HIRRU/24-92   AC A0A3M0ITH7.1
#=GS G1U2V8_RABIT/25-95       AC G1U2V8.1
#=GS A0A1S2ZQQ3_ERIEU/25-93   AC A0A1S2ZQQ3.1
#=GS APOC3_CANLF/22-90        AC P12279.1
#=GS A0A287CXI9_ICTTR/22-90   AC A0A287CXI9.1
#=GS A0A493T822_ANAPP/22-89   AC A0A493T822.1
#=GS A0A2Y9E3I8_TRIMA/26-94   AC A0A2Y9E3I8.1
#=GS L9KV54_TUPCH/22-90       AC L9KV54.1
#=GS A0A2K5EEI1_AOTNA/40-108  AC A0A2K5EEI1.1
#=GS H2NFD8_PONAB/22-90       AC H2NFD8.1
#=GS A0A384BAB1_BALAS/22-90   AC A0A384BAB1.1
D3YXN8_MOUSE/22-53                  ..........EVEGSLLLG....SVQ....GYMEQASKTVQDALS.SVQES------.....-----------------------..--------........
A0A0R4J1N3_MOUSE/22-90              ..........EVEGSLLLG....SVQ....GYMEQASKTVQDALS.SVQESDIAVVA.....RGWMDNHFRSLKGYWSKFTDKFT..GFWDSNPE........
A0A096NCP4_PAPAN/40-108             ..........EAEDTSLLG....FMQ....GYMQHATKTAKDALT.SVQESQVAQQA.....RGWVTDGFSSLKDYWSTVKDKLS..GFWDLNPE........
A0A2K6U3D9_SAIBB/22-90              ..........EAEDTSLLS....FMQ....DYMQHATETAKDALT.KVQESQVAQQA.....RDWVTDGFSSLKDYWSTIKGKFS..GFWDSNPE........
A0A2U3YIH1_LEPWE/22-90              ..........EAEDPSLLG....LMQ....GYMQHATKTAQDTLT.SVQESQVAQRA.....RDWMTDGFSSLKDYWSTFKGKFS..GFWDSASE........
A0A1A6H7W0_NEOLE/22-90              .........e-GEGSLLLG....SVQ....GYMEHAAKKVQDALT.SVQKSEMAVQA.....RGWMDGGFSSLKGYWSKFTDKFS..SLWDSTP-k.......
APOC3_HUMAN/22-90                   ..........EAEDASLLS....FMQ....GYMKHATKTAKDALS.SVQESQVAQQA.....RGWVTDGFSSLKDYWSTVKDKFS..EFWDLDPE........
#=GR APOC3_HUMAN/22-90        SS    ..........--TTS-THH....HHH....HHHHHHGGGHHHHHH.GGGGGGGHHHH.....HHHTTTTTTHHHHHHHHHHHHTT..GGGS-SS-........
A0A1S3EMA4_DIPOR/17-85              .........s-AQSASLLD....FMQ....GYVHHATKTAQDALT.SMKEYPMAEQA.....RGWMNGGLSSLKDYWSTFAGKFS..GFWDSTPE........
APOC3_MOUSE/22-90                   ..........EVEGSLLLG....SVQ....GYMEQASKTVQDALS.SVQESDIAVVA.....RGWMDNHFRFLKGYWSKFTDKFT..GFWDSNPE........
A0A2R8ZG19_PANPA/22-90              ..........EAEDTSLLS....FMQ....GYMKHATKTAKDALS.SVQESQVAQQA.....RGWVTDGFSSLKDYWSTVKDKFS..EFWDSDPE........
E9QP56_MOUSE/60-128                 ..........EVEGSLLLG....SVQ....GYMEQASKTVQDALS.SVQESDIAVVA.....RGWMDNHFRSLKGYWSKFTDKFT..GFWDSNPE........
APOC3_CAVPO/22-90                   ..........EIQESSLLG....VMK....DYMQQASKTANEMLT.KVQESQVAENA.....REWMTESLDSMKGYWTSLIGRLS..GFLDSTP-s.......
G3QY94_GORGO/22-90                  ..........EAEDTSLLS....FMQ....GYMKHATKTAKDALS.SVQESQVAQQA.....RGWVTDGFSSLKDYWSTVKDKFS..EFWDLDPE........
A0A2K5P9G2_CEBCA/40-108             ..........EAEDTSLLS....FMQ....DYMQHATKTAKDTLT.KVQETQVAQQA.....RDWVTDGFSSLTDYWSTIKGKFS..RFWDSNPE........
A0A2K5P467_CERAT/22-90              ..........EAEDTSLLG....FMQ....GYMQHATKTAKDALT.SVQESQVAQQA.....RGWVTDGFSSLKDYWSTVKDKLS..GFWDLNPE........
A0A2U3X0U6_ODORO/22-90              ..........EEEDPSLLG....LMQ....GYMQHATKTAQDTLT.SVQESQVAQRA.....RGWMTDGFSSLKDYWSTFKGKFS..GFWDSASE........
A0A2U4BWI3_TURTR/22-63              ..........EADDASLLG....KMQ....DYMKQATKTATDTLT.SMQESQVAQQA.....R----------------------..--------fal.....
APOC3_HETGA/22-96                   ..........ETEDASLLGymqdYMQ....GYMEHASKTAQDALT.RVQDSQMAQQA.....RGWMSDSLSSLQDYWSSFKGKWSgfGFWDATPE........
A0A2K5XUF4_MANLE/40-108             .........d-AEDTSLLG....FMQ....GYMQHATKTAKDALT.SVQESQVAQQA.....RGWVTDGFSSLKDYWSTVKDKLS..GFWDLNPE........
A0A384C068_URSMA/22-90              ..........EAEDPSLLG....LMQ....GYVQHATKTAQDTLT.SVQESQVAQRA.....RDWMTDGISSLKDYWSTFKDKFS..GLWDLASE........
F1PDJ0_CANLF/22-90                  ..........EEEDPSLLG....LMQ....GYMQHATKTAQDTLT.SVQESQVAQRA.....RGWMTDSFSSLKDYWSTFKGKFT..GFWDSASE........
L5KKQ2_PTEAL/22-90                  ..........EAEDASLLG....FMQ....DYVQQASKTAQAALT.SIQESQVAQQA.....RGWMTDGFSSLKDYWSTLKDKFS..EFWDSTPE........
A0A2K6RCA4_RHIRO/22-90              ..........EAEDTSLLS....FMQ....GYMQHATKTAKDALT.SVQESQMAQQA.....RGWVTDGFSSLKDYWSTVKDKFS..EFWDLNPE........
A0A2K6FT92_PROCO/39-107             ..........EAGEASLLG....VMQ....GYVQRATKTAQEALT.SVQESHMAQQA.....RGWMTGGLSSLKEYWSTMKDKFS..GFWDSIPE........
A0A1S3EL15_DIPOR/22-90              ..........EAESASLLD....FMQ....GYVHHATKTAQDALT.SMKEYPMAEQA.....RGWMNGGLSSLKDYWSTFAGKFS..GFWDSTPE........
A0A452S109_URSAM/22-90              ..........EAEDPSLLG....LMQ....GYVQHATKTAQDTLT.SVQESQVAQRA.....RDWMTDGISSLKDYWSTFKDKFS..GLWDLASE........
A0A2Y9F8Y7_PHYMC/22-90              ..........EAEDASLLG....KMQ....DYMKQATKTAKDALT.SMQESQVAQQA.....RGWVTDSFSSLKDYWSTFKGKFS..EFWDSAP-s.......
F7FXR5_CALJA/40-108                 ..........EAEDTSLVS....FMQ....DYMQHATKTAKDALS.KVQESQVAQQA.....RDWVTDGFSSLKDYWSTIKGKFS..EFWDSSPE........
A0A0D9S396_CHLSB/22-90              ..........EAEDTSLLG....FMQ....GYVQHATKTAKDALT.SVQESQVAQQA.....RGWVTDGFSSLKDYWSTVKDKLS..GFWDLNPE........
APOC3_MACFA/22-90                   ..........EAEDTSLLG....FMQ....GYMQHATKTAKDALT.SVQESQVAQQA.....RGWVTDGFSSLKDYWSTVKDKLS..GFWDLNPE........
A0A452EAP5_CAPHI/25-83              .........k-AEEGSLLD....KMK....GYVKEATTTAKDV--.-VQKTRYALTS.....PDWMTESFSSLKDYWSS------..--------diresas.
G1LPY8_AILME/22-90                  ..........EAEDPSLLG....LMQ....GYVQHATKTAQDTLT.SVQESQVAQRA.....RDWMTDGISSLKDYWSTFKGKFS..GLWDLASE........
A0A091DKU6_FUKDA/22-94              ..........ETEDASLLG....YMQdyvqGYVQHASKTAQDALT.KMQDFEMAQQA.....RGWMSDSLSSLQDYWSSFKGKWS..GFWDATHE........
APOC3_BOVIN/22-90                   .........k-AEEGSLLD....KMQ....GYVKEATKTAKDALS.SVQESQVAQQA.....RDWMTESFSSLKDYWSSFKGKFT..DFWESAT-s.......
A0A3Q7W9E7_URSAR/22-90              ..........EAEDPSLLG....LMQ....GYVQHATKTAQDTLT.SVQESQVAQRA.....RDWMTDGISSLKDYWSTFKDKFS..GLWDLASE........
A0A1U7TCH1_TARSY/22-84              ..........EAEDSSLLG....FMQ....GYMQHATKTAQGALT.SVQ------QA.....RGWVSDGFSSLKDYWSTVKGKFS..EFWDSTSE........
A0A340XP38_LIPVE/22-90              ..........EAEDASLLG....KMQ....DYMKQATRTAKDALT.SVQESQVAQQA.....RGWVTDSFSSLKDYWSTFKGKFS..EFWDSAP-n.......
G1R6X4_NOMLE/22-90                  ..........EAEDASLLS....FMQ....GYMKHATKTAKDALT.SVQESQMAQQA.....RGWVTDGFSSLKDYWSTVKDKFS..GFWDSNPE........
A0A2K6U3D7_SAIBB/40-108             ..........EAEDTSLLS....FMQ....DYMQHATETAKDALT.KVQESQVAQQA.....RDWVTDGFSSLKDYWSTIKGKFS..GFWDSNPE........
A0A3Q7S6U0_VULVU/22-90              ..........EEEDPSLLG....LMQ....GYMQHATKTAQDTLT.SVQESQVAQRA.....RGWMTDSFSSLKDYWSTFKGKFT..GFWDSASE........
G3UIL9_LOXAF/26-99                  .........q-SEDASLLD....VMQ....GYVHHAAKTAQDALT.SVQESQMAQHAndlipRDWVTGGFTSLQDYWSTFKGKLS..RLWESTPE........
A0A3L8S109_CHLGU/24-92              ........pe--EPKALVQ....KVQ....ELAQKATDMAKDAFS.RVRESEAAKQA.....RQWLSDNAELAKQRLAWLKEQLA..ELLKKTP-s.......
H0X1N8_OTOGA/22-90                  ..........EAEDASLLG....FMQ....GYMHQATKTAQDALT.RVKEFEMAQQA.....RGWVTDRFSSLKDYWSSVTGKFS..DFWDSSPE........
G1QA13_MYOLU/22-87                  ..........EADEDSLLK....LMQ....DYVQQA----QEALTsSVKDLSMAQEA.....SKWMSNGFNSLKDYWSSLTVPLS..NLWPLAP-g.......
W5NWX6_SHEEP/36-104                 .........k-AEEGSLLD....KMQ....GYVKEATKTAKDALS.SVQESQVAQQA.....RDWMTESFSSLKDYWSSFKGKFT..DFWESAS-n.......
I3NEQ1_ICTTR/52-120                 ..........EAEDASLLS....FMQ....GYMDRATRTAQDALT.KVQDSEMAQRA.....RGWMNGGINSLKDYWSSFTDKFS..GFWESTPD........
A0A2Y9K660_ENHLU/22-90              ..........EAEDPSLLG....LMQ....GYMQHATKTAQDTLT.SVQESQVAQRA.....RGWMTDSFSSLKDYWSTFKGKFS..GFWDSASE........
A0A1D5PK48_CHICK/24-92              ......pdkt----EVVVK....KVQ....EYVKQATEAVKTAFT.TVHESEAAQQA.....RKWLSDNADLVKQQLAKLKEQLA..ELWKLTP-t.......
C9J2Q0_HUMAN/22-55                  ..........EAEDASLLS....FMQ....GYMKHATKTAKDALS.SVQESQV----.....-----------------------..--------........
A0A0G2K8Q1_RAT/22-90                .........e-GEGSLLLG....SMQ....GYMEQASKTVQDALS.SMQESDIAVVA.....RGWMDNRFKSLKGYWSKFTDKFT..GLWESGPE........
APOC3_RAT/22-91                     .........e-GEGSLLLG....SMQ....GYMEQASKTVQDALS.SMQESDIAVVA....sRGWMDNRFKSLKGYWSKFTDKFT..GLWESGPE........
F7FQN1_MACMU/40-108                 ..........EAEDTSLLG....FMQ....DYMQHATKTAKDALT.SVQESQVAQQA.....RGWVTDGFSSLKDYWSTVKDKLS..GFWDLNPE........
A0A2K5HQ06_COLAP/40-108             ..........EAEDTSLLS....FMQ....GYMQHATKTAKDALT.SVQESQMAQQA.....RGWVTDGFSSLKDYWSTVKDKFS..GFWDLNPE........
F6TE12_MONDO/21-89                  .........q-VTEETLLN....RVQ....DYMQQAARQAQEALN.NVQEYDVTKQA.....KDWVTDGISSLHDYWSTWTGKFS..GLWEKAEE........
G3WJF0_SARHA/24-92                  ..........EEEEETILN....RVH....DYMQQAARQAQEALT.TVQESQMAQQA.....KGWMADSFSSLHEYWSTWADKLS..VLWDTAE-k.......
A0A3Q2I0V8_HORSE/21-89              ..........EDKDASLLD....VVQ....GYMQQASKTAKDTLT.SMQESQVAQQA.....RDWVNDGLSSLKDYWGKLKGKFS..SFWDST--fe......
A0A1U7S774_ALLSI/23-83              eepedtnlak---------....--E....NYMQQVTQKIKDTLA.SLDMSGLAQQG.....RQWASEHLDAIQRYVEELKRTF-..--------mp......
B0YIW2_HUMAN/40-108                 ..........EAEDASLLS....FMQ....GYMKHATKTAKDALS.SVQESQVAQQA.....RGWVTDGFSSLKDYWSTVKDKFS..EFWDLDPE........
A0A2K6JP04_RHIBE/22-90              ..........EAEDTSLLS....FMQ....GYMQHATKTAKDALT.SVQESQMAQQA.....RGWVTDGFSSLKDYWSTVKDKFS..EFWDLNPE........
G3I7Q2_CRIGR/22-70                  ..........EAEGSLLLG....SVQ....GYMEHAAKKVQDALT.SVQESEMAVQA.....RCH--------------------..--------lnklhlik
A0A2Y9LYW0_DELLE/22-90              ..........EAEDASLLG....KMQ....DYMKQATKTAKDALT.SVQESQVAQQA.....RGWVTDSFSSLKDYWSTFKGKFS..EFWDSAP-n.......
A0A218UQL8_9PASE/24-92              ........pe--EPKALVQ....KVQ....ELTQKATAMAKDAFS.RVRESEAAKQA.....RQWLSDNAELAKQRLAWLKEQLA..ELLKKTP-a.......
H2R4Y3_PANTR/22-90                  ..........EAEDTSLLS....FMQ....GYMKHATKTAKDALS.SVQESQVAQQA.....RGWVTDGFSSLKDYWSTVKDKFS..EFWDSDPE........
M3WSC8_FELCA/22-90                  ..........EGEDPSLLG....LMQ....GYVQHATKTAQDTLT.TVREFPVAQQA.....RAWVTGRFTSLKDYWSTLTGKFS..GFWDST--fa......
A0A452HG41_9SAUR/64-132             ........pr--EEETIVK....KVQ....DYVHQVAQTAKDALT.KVQESEVAQQA.....RDWVNMRAEDIHQFWDVLKDKFS..TLWEQQP-p.......
A0A1U7QK70_MESAU/22-90              ..........EVEGSLLLG....SVQ....GYMEQATKKVQDALT.SMQKSEVAVRA.....RDWMDGGFTSLKSYWSTFTDTVS..SLWDSSP-k.......
A0A2K6E8F3_MACNE/22-90              ..........EAEDTSLLG....FMQ....GYMQHATKTAKDALT.SVQESQVAQQA.....RGWVTDGFSSLKDYWSTVKDKLS..GFWDLNPE........
M3XYL6_MUSPF/22-90                  ..........EAEDPSLLG....LMQ....GYVQHATKTAQDTLT.SVQESQVAQRA.....RGWMTDSFTSLKDYWSTFKGKFS..GFWDSASE........
APOC3_HORSE/20-88                   ..........EDKDASLLD....VVQ....GYMQQASKTAKDTLT.SMQESQVAQQA.....RDWVNDGLSSLKDYWGKLKGKFS..SFWDST--fe......
A0A452EM11_CAPHI/22-90              .........k-AEEGSLLD....KMQ....GYVKEATKTAKDALS.SVQESQVAQQA.....RDWMTESFSSLKDYWSSFKGKFT..DFWESAS-n.......
A0A0Q3T1Q2_AMAAE/25-92              .......gep----EVLVR....KVQ....EYAQKASAMAKSALS.RVQESEVAQQA.....RQWLSDNVELAKQRLVRFKEQLV..QLWKGT--aa......
APOC3_PIG/22-90                     ..........EAEDTSLLD....KMQ....DYVKQATRTAQDALT.SVKESEVAQQA.....RGWVTDSISSLKDYWSTFKGKFT..DFWDYTP-k.......
A0A3M0ITH7_HIRRU/24-92              ........pe--EQKALVQ....KVQ....ELAQKASAMAKDAYS.RVRESEAAQQA.....RQWLLDNAELAKQRLVWLKEKLA..ELWKKTP-t.......
G1U2V8_RABIT/25-95                  ........dp--KDASLLS....VMQ....GYVQHATKTAHDALS.SMQESQMAQQAs...pRGWVDAGISSLKGYLSTFADKFS..GFWDLSPE........
A0A1S2ZQQ3_ERIEU/25-93              .........v-SEEPSILD....VMQ....DYVHQATKTAQDALT.SVQKFQVAEQA.....RGWMSTHFSTLHDYWSTIASTVT..GFWEPS--ak......
APOC3_CANLF/22-90                   ..........EEEDPSLLG....LMQ....GYMQHATKTAQDTLT.SVQESQVAQRA.....RGWMTDSFSSLKDYCSTFKGKFT..GFWDSASE........
A0A287CXI9_ICTTR/22-90              ..........EAEDASLLS....FMQ....GYMDRATRTAQDALT.KVQDSEMAQRA.....RGWMNGGINSLKDYWSSFTDKFS..GFWESTPD........
A0A493T822_ANAPP/22-89              .......ddt----DTVVR....KVQ....EYVKQATDVVKSVFT.TVQESEAAQQA.....RKWLSDNADVVKQQLARLKEQLS..EFWKLTP-g.......
A0A2Y9E3I8_TRIMA/26-94              .........e-PKDASLLD....VMQ....GYVHHATKTAQDAMT.RVQESHMAQQA.....RDWVTDGVSSLKDYWSTFKSKLS..QFWDLFP-s.......
L9KV54_TUPCH/22-90                  ..........EAEDPTLFG....FMQ....GYMQQASKTAQDALT.NMQKSQVAQQA.....RGWLTDGIDSLKDYWSTFKDKFS..EFWDLTPE........
A0A2K5EEI1_AOTNA/40-108             ..........EAEDTSLLS....FMQ....DYVQHATKTAKDALA.KVQESQVAQQA.....RDWVTDGFSSLKDYWSTIKGRFS..GFWDSNP-q.......
H2NFD8_PONAB/22-90                  ..........EAEDTSLLS....FMQ....GYMKHATKTAKDALT.SVQESQVAQQA.....RGWVTDGFSSLKDYWSTVKDKFS..GFWDLDPE........
A0A384BAB1_BALAS/22-90              ..........EADDASLLG....KMQ....DYMNQATKTAKDALT.SVQESQVAQQA.....RGWVTDSFSSLKDYWSSFKGKFS..EFWDSAP-n.......
#=GC SS_cons                        ..........--TTS-THH....HHH....HHHHHHGGGHHHHHH.GGGGGGGHHHH.....HHHTTTTTTHHHHHHHHHHHHTT..GGGS-SS-........
#=GC seq_cons                       ..........EAEDsSLLu....hMQ....GYMp+ATKTApDALT.SVQESQVAQQA.....RsWhTDuFSSLKDYWSThKsKFS..sFWDtsP-........
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