GenomeNet

Database: Pfam
Entry: Arylesterase
LinkDB: Arylesterase
Original site: Arylesterase 
#=GF ID   Arylesterase
#=GF AC   PF01731.21
#=GF DE   Arylesterase
#=GF AU   Bashton M;0000-0002-6847-1525
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF AU   Fenech M;0000-0001-7933-4617
#=GF SE   Pfam-B_2101 (release 4.1)
#=GF GA   21.30 21.30;
#=GF TC   21.30 21.30;
#=GF NC   21.20 21.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   9032442
#=GF RT   Purification and characterization of paraoxon hydrolase from rat
#=GF RT   liver. 
#=GF RA   Rodrigo L, Gil F, Hernandez AF, Marina A, Vazquez J, Pla A; 
#=GF RL   Biochem J 1997;321:595-601.
#=GF RN   [2]
#=GF RM   8661009
#=GF RT   The human serum paraoxonase/arylesterase gene (PON1) is one
#=GF RT   member of a multigene family. 
#=GF RA   Primo-Parmo SL, Sorenson RC, Teiber J, La Du BN; 
#=GF RL   Genomics 1996;33:498-507.
#=GF DR   INTERPRO; IPR002640;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of arylesterases (Also known as serum
#=GF CC   paraoxonase) EC:3.1.1.2. These enzymes hydrolyse
#=GF CC   organophosphorus esters such as paraoxon and are found in the
#=GF CC   liver and blood. They confer resistance to organophosphate
#=GF CC   toxicity [1]. Human arylesterase (PON1) Swiss:P27169 is
#=GF CC   associated with HDL and may protect against LDL oxidation [2].
#=GF SQ   881
#=GS A0A3Q0SSS2_AMPCI/168-253    AC A0A3Q0SSS2.1
#=GS A0A2K5SD83_CEBCA/168-253    AC A0A2K5SD83.1
#=GS F6R1T9_HORSE/167-252        AC F6R1T9.1
#=GS A0A0N4ZH65_PARTI/218-304    AC A0A0N4ZH65.1
#=GS A0A2K5RM74_CEBCA/188-273    AC A0A2K5RM74.1
#=GS A0A428TAX3_9HYPO/180-259    AC A0A428TAX3.1
#=GS H0YTL8_TAEGU/180-265        AC H0YTL8.1
#=GS A0A1I7U490_9PELO/177-262    AC A0A1I7U490.1
#=GS G3RXU5_GORGO/188-273        AC G3RXU5.2
#=GS A0A0A1MY91_RHIZD/195-276    AC A0A0A1MY91.1
#=GS G1S0R9_NOMLE/168-253        AC G1S0R9.1
#=GS E3LMY2_CAERE/177-262        AC E3LMY2.1
#=GS R0LPL1_ANAPL/108-193        AC R0LPL1.1
#=GS A0A2Y9RP29_TRIMA/167-252    AC A0A2Y9RP29.1
#=GS E3LJL8_CAERE/164-247        AC E3LJL8.1
#=GS A0A2H5ZHN6_9BACT/159-245    AC A0A2H5ZHN6.1
#=GS G3RBS0_GORGO/167-252        AC G3RBS0.1
#=GS A0A0P7BPW1_9BACT/154-239    AC A0A0P7BPW1.1
#=GS A0A3Q1C4Y9_AMPOC/167-253    AC A0A3Q1C4Y9.1
#=GS A0A091ILW7_EGRGA/147-232    AC A0A091ILW7.1
#=GS A0A2T4AZ28_9HYPO/198-246    AC A0A2T4AZ28.1
#=GS A0A384BQE6_URSMA/167-252    AC A0A384BQE6.1
#=GS A0A3N4LDB6_9PEZI/199-292    AC A0A3N4LDB6.1
#=GS A0A370T9Z0_9PEZI/196-284    AC A0A370T9Z0.1
#=GS N4U128_FUSC1/180-270        AC N4U128.1
#=GS A0A2K5E920_AOTNA/168-253    AC A0A2K5E920.1
#=GS A0A3B4EI77_PYGNA/145-230    AC A0A3B4EI77.1
#=GS G3SVF4_LOXAF/169-254        AC G3SVF4.1
#=GS A0A384BQS2_URSMA/168-253    AC A0A384BQS2.1
#=GS R7UZD7_CAPTE/158-241        AC R7UZD7.1
#=GS A0A2K6L3D4_RHIBE/181-266    AC A0A2K6L3D4.1
#=GS A0A1S3APH1_ERIEU/167-252    AC A0A1S3APH1.1
#=GS W4Z8K2_STRPU/145-228        AC W4Z8K2.1
#=GS A0A318CPW2_9DELT/160-245    AC A0A318CPW2.1
#=GS A0A0G2HL39_9PEZI/205-293    AC A0A0G2HL39.1
#=GS G5AJS8_HETGA/167-252        AC G5AJS8.1
#=GS A0A2T3ZIE1_9HYPO/199-293    AC A0A2T3ZIE1.1
#=GS A0A452EDU6_CAPHI/170-255    AC A0A452EDU6.1
#=GS A0A3Q3BEF6_KRYMA/123-207    AC A0A3Q3BEF6.1
#=GS A0A3M0K184_HIRRU/167-252    AC A0A3M0K184.1
#=GS A0A368FRW1_ANCCA/143-228    AC A0A368FRW1.1
#=GS G0NWF1_CAEBE/177-236        AC G0NWF1.1
#=GS A0A428TFI1_9HYPO/200-270    AC A0A428TFI1.1
#=GS H3EA06_PRIPA/189-274        AC H3EA06.2
#=GS X0D2T8_FUSOX/180-270        AC X0D2T8.1
#=GS A0A2K6CUR5_MACNE/188-273    AC A0A2K6CUR5.1
#=GS G3QPZ3_GORGO/168-253        AC G3QPZ3.1
#=GS MEC6_CAEEL/178-263          AC O01811.2
#=GS A0A452EDV8_CAPHI/162-247    AC A0A452EDV8.1
#=GS A8XEG4_CAEBR/165-249        AC A8XEG4.1
#=GS A0A2I3SWU0_PANTR/181-266    AC A0A2I3SWU0.1
#=GS A0A2K6S4D3_SAIBB/167-252    AC A0A2K6S4D3.1
#=GS I2EQ92_EMTOG/154-238        AC I2EQ92.1
#=GS A0A3P8XIW4_ESOLU/168-253    AC A0A3P8XIW4.1
#=GS A0A178ZER7_9EURO/201-291    AC A0A178ZER7.1
#=GS A0A367K4U8_9FUNG/195-276    AC A0A367K4U8.1
#=GS A0A1U7RA96_MESAU/168-253    AC A0A1U7RA96.1
#=GS A0A317SBF1_9PEZI/197-291    AC A0A317SBF1.1
#=GS A0A316VKP0_9BASI/201-289    AC A0A316VKP0.1
#=GS A0A3Q1F5V4_9TELE/77-160     AC A0A3Q1F5V4.1
#=GS A0A3P9N3J1_POERE/167-252    AC A0A3P9N3J1.1
#=GS A0A2Y9E359_TRIMA/167-252    AC A0A2Y9E359.1
#=GS A0A3Q1CP24_AMPOC/167-253    AC A0A3Q1CP24.1
#=GS A0A0D2B8S7_9EURO/194-293    AC A0A0D2B8S7.1
#=GS G3XAK4_HUMAN/167-217        AC G3XAK4.1
#=GS A0A093HGW6_STRCA/147-232    AC A0A093HGW6.1
#=GS A0A452E7W8_CAPHI/167-252    AC A0A452E7W8.1
#=GS W4YZ77_STRPU/27-111         AC W4YZ77.1
#=GS H0WYI2_OTOGA/168-253        AC H0WYI2.1
#=GS A0A3P9C6L8_9CICH/141-226    AC A0A3P9C6L8.1
#=GS A0A2G8KT43_STIJA/169-253    AC A0A2G8KT43.1
#=GS A0A1M6H4L6_9FLAO/158-243    AC A0A1M6H4L6.1
#=GS A0A2S7T3T0_9FLAO/145-230    AC A0A2S7T3T0.1
#=GS G0NJN5_CAEBE/165-249        AC G0NJN5.1
#=GS A0A2U1VWM8_9PROT/186-268    AC A0A2U1VWM8.1
#=GS A0A2K5IAG9_COLAP/168-253    AC A0A2K5IAG9.1
#=GS A0A3B3VEB4_9TELE/140-224    AC A0A3B3VEB4.1
#=GS A0A3B4UKE3_SERDU/168-253    AC A0A3B4UKE3.1
#=GS A0A2B7Z215_9EURO/197-289    AC A0A2B7Z215.1
#=GS C9JZ99_HUMAN/167-237        AC C9JZ99.1
#=GS A0A3Q3LH51_9LABR/167-253    AC A0A3Q3LH51.1
#=GS A0A397V708_9GLOM/153-241    AC A0A397V708.1
#=GS H3DRJ7_PRIPA/168-253        AC H3DRJ7.2
#=GS A0A016VEY5_9BILA/146-231    AC A0A016VEY5.1
#=GS A0A3Q2CMZ6_CYPVA/167-252    AC A0A3Q2CMZ6.1
#=GS A0A3Q1C2Q0_AMPOC/167-253    AC A0A3Q1C2Q0.1
#=GS A0A3Q2LPL2_HORSE/165-250    AC A0A3Q2LPL2.1
#=GS A0A2I1FUD9_9GLOM/179-263    AC A0A2I1FUD9.1
#=GS K7GHS4_PELSI/147-232        AC K7GHS4.1
#=GS A0A176H4Z2_9GAMM/172-258    AC A0A176H4Z2.1
#=GS A0A493STB0_ANAPP/151-236    AC A0A493STB0.1
#=GS A0A015N968_RHIIW/181-268    AC A0A015N968.1
#=GS A0A433TT17_ELYCH/176-261    AC A0A433TT17.1
#=GS W5MYF0_LEPOC/170-254        AC W5MYF0.1
#=GS A0A2T4H229_FUSCU/156-245    AC A0A2T4H229.1
#=GS A0A210Q2T7_MIZYE/165-247    AC A0A210Q2T7.1
#=GS A0A177WET5_BATDL/178-263    AC A0A177WET5.1
#=GS A0A2I3SMF6_PANTR/167-252    AC A0A2I3SMF6.1
#=GS A0A0N4TFK3_BRUPA/89-142     AC A0A0N4TFK3.1
#=GS PON2_RAT/167-252            AC Q6AXM8.1
#=GS A0A0D1WRI9_EXOME/188-277    AC A0A0D1WRI9.1
#=GS A0A2K5CPT3_AOTNA/167-238    AC A0A2K5CPT3.1
#=GS N1RXC3_FUSC4/180-270        AC N1RXC3.1
#=GS A0A0D2IL32_9EURO/190-279    AC A0A0D2IL32.1
#=GS E3ME28_CAERE/158-243        AC E3ME28.1
#=GS X5M752_9RHIZ/171-256        AC X5M752.1
#=GS A0A1S3GQY0_DIPOR/168-253    AC A0A1S3GQY0.1
#=GS A0A2K5LGU8_CERAT/188-273    AC A0A2K5LGU8.1
#=GS G5ANL3_HETGA/163-248        AC G5ANL3.1
#=GS A0A340WUJ2_LIPVE/190-275    AC A0A340WUJ2.1
#=GS G7P1C3_MACFA/167-252        AC G7P1C3.1
#=GS A0A226NIE7_CALSU/167-252    AC A0A226NIE7.1
#=GS A0A0B4HMC9_METMF/201-249    AC A0A0B4HMC9.1
#=GS I3MXR0_ICTTR/167-252        AC I3MXR0.1
#=GS A0A2Y9JH35_ENHLU/177-262    AC A0A2Y9JH35.1
#=GS PON2_BOVIN/167-252          AC Q58DS7.1
#=GS A0A2G8LDX8_STIJA/199-284    AC A0A2G8LDX8.1
#=GS A0A2I3LIR7_PAPAN/151-236    AC A0A2I3LIR7.1
#=GS A0A340WMG0_LIPVE/167-252    AC A0A340WMG0.1
#=GS A0A2H3TMJ9_FUSOX/206-301    AC A0A2H3TMJ9.1
#=GS M3WNF1_FELCA/168-253        AC M3WNF1.2
#=GS A0A395MFC4_9HYPO/180-269    AC A0A395MFC4.1
#=GS F1SFA1_PIG/168-253          AC F1SFA1.3
#=GS F1SFA2_PIG/167-252          AC F1SFA2.2
#=GS T1F1D8_HELRO/121-201        AC T1F1D8.1
#=GS A0A0D9RKI9_CHLSB/167-252    AC A0A0D9RKI9.1
#=GS A0A3D8Y6A2_9BACT/213-276    AC A0A3D8Y6A2.1
#=GS PON2_CHICK/167-252          AC Q90952.1
#=GS A0A2R9A5Z1_PANPA/168-253    AC A0A2R9A5Z1.1
#=GS A0A0H2RQV6_9AGAM/190-279    AC A0A0H2RQV6.1
#=GS A0A0K0FUX7_STRVS/215-300    AC A0A0K0FUX7.1
#=GS A3UFZ6_9RHOB/162-247        AC A3UFZ6.1
#=GS A0A423WJC9_9PEZI/205-293    AC A0A423WJC9.1
#=GS A0A074S820_9AGAM/150-248    AC A0A074S820.1
#=GS A0A3P8NAR0_ASTCA/167-253    AC A0A3P8NAR0.1
#=GS A0A3P8NAR3_ASTCA/144-229    AC A0A3P8NAR3.1
#=GS G3VTD9_SARHA/138-223        AC G3VTD9.1
#=GS A0A0B2WKS6_METAS/203-302    AC A0A0B2WKS6.1
#=GS A0A2I2ZNK6_GORGO/130-197    AC A0A2I2ZNK6.1
#=GS A0A3B3CKD3_ORYME/167-252    AC A0A3B3CKD3.1
#=GS PON1_RAT/168-253            AC P55159.3
#=GS A0A091W911_OPIHO/143-228    AC A0A091W911.1
#=GS T1G9J6_HELRO/132-219        AC T1G9J6.1
#=GS A0A493TNQ8_ANAPP/218-303    AC A0A493TNQ8.1
#=GS A0A418WG47_9PROT/155-236    AC A0A418WG47.1
#=GS A0A3B3U1E4_9TELE/138-223    AC A0A3B3U1E4.1
#=GS A0A3Q7VLG1_URSAR/167-252    AC A0A3Q7VLG1.1
#=GS W9H8I9_9PROT/153-233        AC W9H8I9.1
#=GS A0A0Q3X6G9_AMAAE/167-252    AC A0A0Q3X6G9.1
#=GS J3QT77_HUMAN/155-240        AC J3QT77.1
#=GS A0A428P9D6_9HYPO/180-268    AC A0A428P9D6.1
#=GS A0A1S3HXP2_LINUN/177-259    AC A0A1S3HXP2.1
#=GS A7HUX8_PARL1/170-254        AC A7HUX8.1
#=GS A0A3B4D6L4_PYGNA/160-245    AC A0A3B4D6L4.1
#=GS A0A423XG26_9PEZI/185-274    AC A0A423XG26.1
#=GS A0A0D1Z2L9_EXOME/188-285    AC A0A0D1Z2L9.1
#=GS C6H335_AJECH/153-243        AC C6H335.1
#=GS G1S0T5_NOMLE/167-252        AC G1S0T5.1
#=GS A0A096MWI7_PAPAN/167-237    AC A0A096MWI7.2
#=GS A0A2Y9PHL0_DELLE/167-252    AC A0A2Y9PHL0.1
#=GS A0A2I4B8V0_9TELE/169-254    AC A0A2I4B8V0.1
#=GS A0A210QPJ7_MIZYE/160-242    AC A0A210QPJ7.1
#=GS I3J3S7_ORENI/165-250        AC I3J3S7.1
#=GS A0A2K5JUX3_COLAP/167-237    AC A0A2K5JUX3.1
#=GS Q966L1_CAEEL/166-250        AC Q966L1.1
#=GS A0A3Q4HN60_NEOBR/170-255    AC A0A3Q4HN60.1
#=GS F6KQD9_PIG/167-252          AC F6KQD9.1
#=GS A0A2G8KT38_STIJA/168-252    AC A0A2G8KT38.1
#=GS F7D0R7_CALJA/188-273        AC F7D0R7.2
#=GS A0A158P868_ANGCA/152-232    AC A0A158P868.1
#=GS A0A3P9N348_POERE/169-252    AC A0A3P9N348.1
#=GS A0A3P6SKQ6_LITSI/110-195    AC A0A3P6SKQ6.1
#=GS F9FCJ8_FUSOF/560-650        AC F9FCJ8.1
#=GS E2RPW3_CANLF/168-253        AC E2RPW3.2
#=GS A0A364MY76_9PLEO/127-207    AC A0A364MY76.1
#=GS A0A395HFT0_9EURO/188-281    AC A0A395HFT0.1
#=GS A0A2K5QUA3_CEBCA/167-238    AC A0A2K5QUA3.1
#=GS A0A3Q1G1D2_9TELE/69-126     AC A0A3Q1G1D2.1
#=GS A0A197KA70_9FUNG/265-350    AC A0A197KA70.1
#=GS D5GAR4_TUBMM/179-274        AC D5GAR4.1
#=GS A0A3P8NAV1_ASTCA/168-253    AC A0A3P8NAV1.1
#=GS C3Z2J1_BRAFL/141-226        AC C3Z2J1.1
#=GS A0A428Q9A8_9HYPO/180-269    AC A0A428Q9A8.1
#=GS A0A2V5H270_9EURO/187-274    AC A0A2V5H270.1
#=GS PON1_HUMAN/168-253          AC P27169.3
#=GS A0A2G5B5I3_COERN/195-277    AC A0A2G5B5I3.1
#=GS A0A2K6PQP3_RHIRO/167-237    AC A0A2K6PQP3.1
#=GS A0A2T7PVD3_POMCA/478-563    AC A0A2T7PVD3.1
#=GS A0A2K6DIG5_MACNE/167-237    AC A0A2K6DIG5.1
#=GS A0A3P8T5R3_AMPPE/167-253    AC A0A3P8T5R3.1
#=GS A0A2Y9JDB0_ENHLU/167-252    AC A0A2Y9JDB0.1
#=GS A0A0D2M9M6_9AGAR/191-276    AC A0A0D2M9M6.1
#=GS A0A2L2T7R7_9HYPO/177-266    AC A0A2L2T7R7.1
#=GS V5G7L8_BYSSN/183-275        AC V5G7L8.1
#=GS H3DM82_TETNG/166-252        AC H3DM82.1
#=GS A0A0D2HBX3_9EURO/154-245    AC A0A0D2HBX3.1
#=GS A0A1R3RVP9_ASPC5/188-285    AC A0A1R3RVP9.1
#=GS A0A2K6CUR2_MACNE/181-266    AC A0A2K6CUR2.1
#=GS A0A2U9AYQ5_SCOMX/167-253    AC A0A2U9AYQ5.1
#=GS A0A2T7PVD5_POMCA/124-209    AC A0A2T7PVD5.1
#=GS A0A1Q5TRR2_9EURO/195-293    AC A0A1Q5TRR2.1
#=GS A0A0M9EU64_FUSLA/177-266    AC A0A0M9EU64.1
#=GS A0A176H982_9GAMM/166-252    AC A0A176H982.1
#=GS A0A0C9MB16_9FUNG/210-290    AC A0A0C9MB16.1
#=GS A0A2R9BCI1_PANPA/168-253    AC A0A2R9BCI1.1
#=GS L5KMI8_PTEAL/164-249        AC L5KMI8.1
#=GS A0A2S5BE87_9BASI/262-348    AC A0A2S5BE87.1
#=GS A0A3P9C752_9CICH/144-229    AC A0A3P9C752.1
#=GS A0A2K5U8C4_MACFA/181-266    AC A0A2K5U8C4.1
#=GS A0A2Z6QPH8_9GLOM/180-265    AC A0A2Z6QPH8.1
#=GS A8XGE3_CAEBR/177-262        AC A8XGE3.1
#=GS X0D4B6_FUSOX/206-303        AC X0D4B6.1
#=GS A0A368GTE4_ANCCA/183-268    AC A0A368GTE4.1
#=GS A0A1L8FVS2_XENLA/169-254    AC A0A1L8FVS2.1
#=GS U9SSG7_RHIID/179-263        AC U9SSG7.1
#=GS A0A0A1P0A3_RHIZD/195-276    AC A0A0A1P0A3.1
#=GS A0A2H3GHE9_FUSOX/206-303    AC A0A2H3GHE9.1
#=GS A0A2I1FU59_9GLOM/179-265    AC A0A2I1FU59.1
#=GS A0A452QPU4_URSAM/167-252    AC A0A452QPU4.1
#=GS A0A1G7BGP4_9PROT/164-244    AC A0A1G7BGP4.1
#=GS C3Z8V1_BRAFL/130-215        AC C3Z8V1.1
#=GS A0A2I4B8P1_9TELE/167-252    AC A0A2I4B8P1.1
#=GS A0A3Q1AM30_AMPOC/167-253    AC A0A3Q1AM30.1
#=GS A0A2Y9JD64_ENHLU/167-252    AC A0A2Y9JD64.1
#=GS A0A3Q1C4W2_AMPOC/167-253    AC A0A3Q1C4W2.1
#=GS H2QUY6_PANTR/188-273        AC H2QUY6.1
#=GS PON2_MELGA/167-252          AC Q91090.1
#=GS F7FN35_CALJA/167-238        AC F7FN35.2
#=GS Q21427_CAEEL/158-243        AC Q21427.2
#=GS A0A2U3XGV9_LEPWE/167-252    AC A0A2U3XGV9.1
#=GS A0A0K6G6Y6_9AGAM/206-306    AC A0A0K6G6Y6.1
#=GS A0A372RL36_9GLOM/180-265    AC A0A372RL36.1
#=GS A0A2U4AQF1_TURTR/167-252    AC A0A2U4AQF1.1
#=GS A0A2R9A2N6_PANPA/181-266    AC A0A2R9A2N6.1
#=GS A0A2A2L035_9BILA/166-251    AC A0A2A2L035.1
#=GS A0A2Y9PHL9_DELLE/153-238    AC A0A2Y9PHL9.1
#=GS A0A1Q6A6Q0_9SPHI/21-64      AC A0A1Q6A6Q0.1
#=GS A0A1S2ZPI7_ERIEU/168-253    AC A0A1S2ZPI7.1
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