GenomeNet

Database: Pfam
Entry: AsiA
LinkDB: AsiA
Original site: AsiA 
#=GF ID   AsiA
#=GF AC   PF09010.11
#=GF DE   Anti-Sigma Factor A
#=GF AU   Mistry J;0000-0003-2479-5322
#=GF AU   Sammut SJ;0000-0003-4472-904X
#=GF SE   pdb_1jr5
#=GF GA   25.00 25.00;
#=GF TC   27.10 53.80;
#=GF NC   23.70 19.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   11830637
#=GF RT   Solution structure and stability of the anti-sigma factor AsiA:
#=GF RT   implications for novel functions. 
#=GF RA   Urbauer JL, Simeonov MF, Urbauer RJ, Adelman K, Gilmore JM,
#=GF RA   Brody EN; 
#=GF RL   Proc Natl Acad Sci U S A. 2002;99:1831-1835.
#=GF DR   INTERPRO; IPR015100;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Anti-sigma factor A is a transcriptional inhibitor that inhibits
#=GF CC   sigma 70-directed transcription by weakening its interaction
#=GF CC   with the core of the host's RNA polymerase. It is an all-helical
#=GF CC   protein, composed of six helical segments and intervening loops
#=GF CC   and turns, as well as a helix-turn-helix DNA binding motif,
#=GF CC   although neither free anti-sigma factor nor anti-sigma factor
#=GF CC   bound to sigma-70 has been shown to interact directly with DNA.
#=GF CC   In solution, the protein forms a symmetric dimer of small (10.59
#=GF CC   kDa) protomers, which are composed of helix and coil regions and
#=GF CC   are devoid of beta-strand/sheet secondary structural elements
#=GF CC   [1].
#=GF SQ   63
#=GS E5DRZ5_9CAUD/2-82        AC E5DRZ5.1
#=GS A0A0A0Q3M9_9CAUD/1-81    AC A0A0A0Q3M9.1
#=GS A0A0U4IH54_9CAUD/8-90    AC A0A0U4IH54.1
#=GS E5E4L6_9CAUD/2-80        AC E5E4L6.1
#=GS A0A060AMS7_9CAUD/4-84    AC A0A060AMS7.1
#=GS A0A1Z1LYR6_9CAUD/1-81    AC A0A1Z1LYR6.1
#=GS E1A2L6_9CAUD/2-82        AC E1A2L6.1
#=GS A0A0G2SSC2_9CAUD/1-82    AC A0A0G2SSC2.1
#=GS A8R9N6_9CAUD/1-81        AC A8R9N6.1
#=GS ASIA_BPT4/2-81           AC P32267.1
#=GS ASIA_BPT4/2-81           DR PDB; 6K4Y I; 3-81;
#=GS ASIA_BPT4/2-81           DR PDB; 1JR5 B; 2-81;
#=GS ASIA_BPT4/2-81           DR PDB; 1TKV A; 2-81;
#=GS ASIA_BPT4/2-81           DR PDB; 1TLH A; 2-81;
#=GS ASIA_BPT4/2-81           DR PDB; 1JR5 A; 2-81;
#=GS ASIA_BPT4/2-81           DR PDB; 1TL6 A; 2-81;
#=GS ASIA_BPT4/2-81           DR PDB; 1TKV B; 2-81;
#=GS A0A2R3ZXD5_9CAUD/1-81    AC A0A2R3ZXD5.1
#=GS A0A240F458_9CAUD/2-83    AC A0A240F458.1
#=GS E3SF69_9CAUD/1-81        AC E3SF69.1
#=GS A0A0A0YQI0_9CAUD/1-81    AC A0A0A0YQI0.1
#=GS A0A2S1GM14_9CAUD/1-82    AC A0A2S1GM14.1
#=GS A0A3T0IMA2_9CAUD/1-81    AC A0A3T0IMA2.1
#=GS Q19CE8_9CAUD/1-83        AC Q19CE8.1
#=GS A0A2I6PF68_9CAUD/1-83    AC A0A2I6PF68.1
#=GS A0A3Q9R7G8_9CAUD/2-82    AC A0A3Q9R7G8.1
#=GS G0YKD2_9CAUD/2-80        AC G0YKD2.2
#=GS A0A159B7V8_9CAUD/1-81    AC A0A159B7V8.1
#=GS A0A2Z4QD52_9CAUD/2-81    AC A0A2Z4QD52.1
#=GS A0A1B1P9C0_9CAUD/1-81    AC A0A1B1P9C0.1
#=GS A0A0B5A2R8_9CAUD/1-81    AC A0A0B5A2R8.1
#=GS R9TEX8_9CAUD/10-94       AC R9TEX8.1
#=GS A0A249XX03_9CAUD/1-82    AC A0A249XX03.1
#=GS A0A4D6BGZ1_9CAUD/2-83    AC A0A4D6BGZ1.1
#=GS A0A291LE78_9CAUD/3-83    AC A0A291LE78.1
#=GS A0A192YBU6_9CAUD/1-77    AC A0A192YBU6.1
#=GS I6XM06_9CAUD/3-83        AC I6XM06.1
#=GS A0A2K9V665_9CAUD/1-81    AC A0A2K9V665.1
#=GS E5EQ30_9CAUD/1-80        AC E5EQ30.1
#=GS Q56ED8_9CAUD/2-83        AC Q56ED8.1
#=GS E5FJ32_9CAUD/1-81        AC E5FJ32.1
#=GS A0A411BBZ7_9CAUD/3-83    AC A0A411BBZ7.1
#=GS Q7Y4Q5_BPR69/2-81        AC Q7Y4Q5.1
#=GS E5DHZ2_9CAUD/1-81        AC E5DHZ2.1
#=GS Q06E80_BPR32/2-81        AC Q06E80.1
#=GS V9M046_9CAUD/10-94       AC V9M046.1
#=GS K0G7R3_9CAUD/2-81        AC K0G7R3.1
#=GS J7I4K9_9CAUD/1-83        AC J7I4K9.1
#=GS I7J414_9CAUD/1-81        AC I7J414.1
#=GS A0A2U7NLX5_9CAUD/20-101  AC A0A2U7NLX5.1
#=GS J7KLV4_9CAUD/3-84        AC J7KLV4.1
#=GS A0A345AV77_9CAUD/2-82    AC A0A345AV77.1
#=GS A0A2I7QXC0_9CAUD/6-90    AC A0A2I7QXC0.1
#=GS Q6U976_9CAUD/2-83        AC Q6U976.1
#=GS Q6WHK8_BPKVM/10-94       AC Q6WHK8.1
#=GS A0A023W6W7_9CAUD/1-95    AC A0A023W6W7.1
#=GS E5EZ20_9CAUD/2-80        AC E5EZ20.1
#=GS I6YMP8_9CAUD/3-83        AC I6YMP8.1
#=GS D9I6I4_9CAUD/1-80        AC D9I6I4.1
#=GS A0A0U4JUL8_9CAUD/2-81    AC A0A0U4JUL8.1
#=GS E5DQQ2_9CAUD/2-82        AC E5DQQ2.1
#=GS M1EAI1_9CAUD/1-81        AC M1EAI1.1
#=GS A0A2I6UFL0_9CAUD/1-81    AC A0A2I6UFL0.1
#=GS A0A0B6VLD1_9CAUD/1-80    AC A0A0B6VLD1.1
#=GS A0A1B0VW24_9CAUD/1-81    AC A0A1B0VW24.1
#=GS Q76YA4_9CAUD/2-82        AC Q76YA4.1
#=GS A0A411BIC7_9CAUD/3-84    AC A0A411BIC7.1
#=GS A0A2Z5ZCZ7_9CAUD/2-81    AC A0A2Z5ZCZ7.1
#=GS A0A0A7HC73_9CAUD/1-81    AC A0A0A7HC73.1
#=GS A0A2D1GMI4_9CAUD/1-81    AC A0A2D1GMI4.1
E5DRZ5_9CAUD/2-82                   .sn--KIEVLKDIVATASILIKFGR.D.D..............ILDTQ.RGFIDFLSTAGFTTPSGKPLTIQNFRVMV..KSLKPSQIKEIFEEFDAGRI-------ydm.....
A0A0A0Q3M9_9CAUD/1-81               .mt--NFEIVSEIATIVSILIKTDC.E.D..............VMGKR.DEFIAFLNELGIRNEASKELNNVSFNKLF..KDLSENEKLLLIEQFNEGY--------edih....
A0A0U4IH54_9CAUD/8-90               ..n-TKIDLIMDMIAALSILIKFDMaD.E..............ILENQ.HNVVAFLDELGFKTLSGQKLTVMNFRYII..SSLRPNDKNKVINEFKMAF--------espki...
E5E4L6_9CAUD/2-80                   .lf----NTLAEIIAVASILIKFGF.D.D..............ILENH.NLFIAYLNELEI-TIQGKKVTSANLYMLT..QEITTSQKKQLIEEFNMGHEP------iyr.....
A0A060AMS7_9CAUD/4-84               .te--STELCRDIVATASILIKFEM.C.H..............IMDSQ.SSFVEFLNAAGFRTVRGKEFSKMSFRKMW..ERLSPSEIKDILSEFDSR---------nfdil...
A0A1Z1LYR6_9CAUD/1-81               ..m-SKIEIVREIVTVASILIKTSC.E.D..............ILEKR.ENFIAFLNELGLRNEHGRELNLANFKKMI..DGLNDDERSSLVEEFNEGF----EDI-y.......
E1A2L6_9CAUD/2-82                   ..n-AKLELVKDIIATVSLLIKLEV.EgE..............ILDTQ.QNLIDFLNEAGFRTVRGLEFTKMSFRQMV..GRLTDEERAEVLTEFSA----------qehye...
A0A0G2SSC2_9CAUD/1-82               .mn--KLETLSEIFAVISILIKFES.E.D..............IIEDE.NLFIAFINELGI-RNNGKLFNKSNLKSLV..KSLSDEEKTKLIEEFNTGH--------kstysl..
A8R9N6_9CAUD/1-81                   mtk---FEIVSEIVTITSILIKTDR.E.D..............ITMKR.DVFIAFLNELGLRNENGNELNNVSFNKLF..KSLSEDEIEQIIEQFNEGF--------edih....
ASIA_BPT4/2-81                      ...NKNIDTVREIITVASILIKFSR.E.D..............IVENR.ANFIAFLNEIGV-THEGRKLNQNSFRKIV..SELTQEDKKTLIDEFNEGF----EGVY........
#=GR ASIA_BPT4/2-81           SS    ...-SHHHHHHHHHHHHHHHHHTTT.H.H..............HHTSH.HHHHHHHHHHT--ESSSSE--HHHHHHHH..HSS-HHHHHHHHHHSHHHH----HHHH........
A0A2R3ZXD5_9CAUD/1-81               ..m-SKIEIVREIVTVASVLIKFGS.E.H..............ILEKR.EHFIAFLNEIGINNDLGRPLNQSNFRKMI..EEMTAEEKQQLVEEFNEGF----ESVY........
A0A240F458_9CAUD/2-83               nys----ENIKDIIATASLLIKFGC.E.D..............ILNKQ.ETFVSFLNELGFRSPTGEEFTRAGFRQMM..KRLPIEQREELIEMFNQGH--------rdvnhq..
E3SF69_9CAUD/1-81                   mtk---FEIVSEIVTVTSILIKTDR.E.D..............ITMKR.DVFIAFLNELGLRNENGNELNNVSFNKLF..KSLSEDEIEQIIEQFNEGF--------edih....
A0A0A0YQI0_9CAUD/1-81               .mt--NFEIVREVVTIASILIKFGR.D.D..............IVEKR.DHFIAFINETHVDDKDWRRLNQGSFRKLI..SELTVDEKKLLVEEFNEGY----EDI-y.......
A0A2S1GM14_9CAUD/1-82               ..m-SKLETVREIITVASILIKFGA.E.D..............ILQGKsDEFVAFLNEIGI-RNEGRELNVASFKKMI..KELSLEDKEILVEEFNEGY--------advyr...
A0A3T0IMA2_9CAUD/1-81               .mt--KIEIVSEIATIVSILIKTDC.E.D..............IMQRR.DEFIAFLNELGIRNEHGKELNGLSYNKLF..KSLTEDERDTLIEQFNEGY--------edih....
Q19CE8_9CAUD/1-83                   msy---NETIKEIISIASVLIKFGC.E.D..............ILNNQ.ELFVSFLNELGLKSPSGEDFTRAGFRQMM..KRLPADQREELVEMFNQGH--------rdinhq..
A0A2I6PF68_9CAUD/1-83               .mn--KLETLSEIFAVISILIKFES.E.D..............IIEDE.NLFIAFINELGI-RNNGKLFNRSNLKSLI..KSLTEDEKKQLIEEFNMGH--------kstysii.
A0A3Q9R7G8_9CAUD/2-82               .vf----ETLAEIAAVVSILIKFGH.D.D..............IIEDK.NLFIAFLNELGI-TINGKKVTAGNLFNLT..QDITNRQKEQLIAEFNIGHAP------iykkl...
G0YKD2_9CAUD/2-80                   .lf----ETLQEIIAVASILIKFGH.D.D..............ILENK.ALFIAFLNELGI-TIGNKKVTATSLWNLT..QDITNRQKEALIEEFLSGHEP------iyr.....
A0A159B7V8_9CAUD/1-81               mtk---FEIVQEIVTVASILTKFNA.E.H..............IMEKR.DEFIAFLNEIGIKNEQGRQLNQSNFRKMV..SELTDEEKRILVEEYNEGF----ESIY........
A0A2Z4QD52_9CAUD/2-81               ...NKDIEIVREIITVASILIKFSR.E.D..............IVEDR.ANFIGFLNEIGI-KKDGRQLNQNSFRKLI..TNLTAEEKKTLISEFNEGF----ENIY........
A0A1B1P9C0_9CAUD/1-81               mtk---FEIVQEIVTVASILTKFNA.E.H..............IMEKR.DEFIAFLNEIGIKNEQGRQLNQSNFRKMV..SELTDEEKRILVEEYNEGF----ESIY........
A0A0B5A2R8_9CAUD/1-81               mtk---LEIIREIVTIVSILIKTDC.D.D..............ILTSR.DGFIAFLNEAGIRNEFGRTLNGANFKKLA..DGLSVEEKEMLIEEFNTGY----EDI-y.......
R9TEX8_9CAUD/10-94                  ...KSTPELALDIAAYASLLVKLGY.E.D..............CVTNQ.KLFVEMCNEAGFRTTTGKEFTQMSFRQMF..ARLPQGTKREVRESFSWGNIPTSESIL........
A0A249XX03_9CAUD/1-82               .mn--KLETLSEIFAVISILIKFES.E.D..............IIEDE.NLFIAFINELGI-RNNGKLFNKSNLKSLV..KSLSDDEKAKLIEEFNTGH--------kstysl..
A0A4D6BGZ1_9CAUD/2-83               .yq----ETIKDIIATASILIKMDR.D.D..............ILDDQ.DLFVEFLNELGYKSPSGEYFTKAGFRQMM..KRIPDDQKTKLVEMFNRGH--------rateqqm.
A0A291LE78_9CAUD/3-83               .it--KVELMKDIVATASILAKYGC.D.D..............ILDTQ.SGFVDFLNELGFTTVRGKPLTIFNFRVMV..SSLTPYQKKEIIKEFDAGRI-------dhl.....
A0A192YBU6_9CAUD/1-77               ..m----NLAEEIVTIVSILIKFEC.D.D..............ILDNQ.ELFVEFLNELGL-RNNGRSLSKVNMATLF..ERMTAAERKRIIENFNIGH--------qsly....
I6XM06_9CAUD/3-83                   .it--KVELMKDIVATASILAKYGC.D.D..............ILDTQ.SGFVDFLNELGFTTVRGKPLTIFNFRVMV..SSLTQYQKKEIIKEFDAGRI-------dhl.....
A0A2K9V665_9CAUD/1-81               mtk---FEIVQEIVTVASILTKFNA.E.H..............IMEKR.DEFIAFLNEIGIKNEQGRQLNQSNFRKMV..SELTDEEKRILVEEYNEGF----ESIY........
E5EQ30_9CAUD/1-80                   .ma---FETLCEIVAVASILIKFGH.D.D..............ILEHR.PLFIAFLNELGI-TVNARKVTSASLFELT..QDITNRQREQLISDFLVGHE-------piyr....
Q56ED8_9CAUD/2-83                   nys----ENIKDIIATASLLIKFGC.E.D..............ILNKQ.ETFVSFLNELGFRSPTGEEFTRAGFRQMM..KRLPIEQREELIEMFNQGH--------rdvnhq..
E5FJ32_9CAUD/1-81                   mtk---FEIVSEIVTVTSILIKTDR.E.D..............ITMKR.DVFIAFLNELGLRNENGNELNNVSFNKLF..KSLSEDEIEQIIEQFNEGF--------edih....
A0A411BBZ7_9CAUD/3-83               .it--KVELMKDIVATASILAKYGC.D.D..............ILDTQ.SGFVDFLNELGFTTVRGKPLTIFNFRVMV..SSLTPYQKKEIIKEFDAGRI-------dhl.....
Q7Y4Q5_BPR69/2-81                   ...NKDIEIVREIITIASILIKFSR.E.D..............IVEDR.ANFIGFLNEIGI-KKDGRQLNQNSFRKLI..TNLTAEEKKTLISEFNEGF----ENIY........
E5DHZ2_9CAUD/1-81                   ..m-SKLEIVREIVTVASVLIKFGS.E.H..............ILEKR.EHFIAFLNEIGIKNDLGRPLNQSNFRKMI..EEMTAEEKQQLVEEFNEGF----ESVY........
Q06E80_BPR32/2-81                   ...NKNIDTVREIITVASILIKFSR.E.D..............IVENR.ANFIAFLNEIGV-THEGRKLNQNSFRKIV..SELTQEDKKTLIDEFNEGF----EGVY........
V9M046_9CAUD/10-94                  ...KSTTQLALDIAAYASLLVKMGF.D.E..............CVTNQ.KLFVEMCNEAGFRTTTGKEFTQMSFRQMF..ARLPHGTKREVRETFSWGNIPQGESIL........
K0G7R3_9CAUD/2-81                   ...NKDIEIVREIITIASILIKFSR.E.D..............IVEDR.ASFIGFLNEIGI-KKDGRQLNQNSFRKLI..TNLTAEEKKTLISEFNEGF----ENIY........
J7I4K9_9CAUD/1-83                   msy---NETIKEIISIASVLIKFGC.E.D..............ILNNQ.ELFVSFLNELGLKSPSGEEFTRAGFRQMM..KRLPADQREELVEMFNQGH--------rdvnhq..
I7J414_9CAUD/1-81                   mte---LEIIREIVTIVSILIKTDC.D.D..............ILTSR.DGFIAFLNEAGIRNEFGRTLNGANFKKLA..DGLSVEEKEMLIEEFNTGY----EDI-y.......
A0A2U7NLX5_9CAUD/20-101             .sf--NKESIMDIIATMSILIKFDA.D.D..............ILDNI.NLFAEYLNELGFRTVEGFELNKYRLKRMFfnSGLSREDMTGLFDE-------------hferlnrk
J7KLV4_9CAUD/3-84                   .yn----ETIKEIISIASVLIKFGC.E.D..............ILNNQ.ELFVSFLNELGLKSPSGEEFTRAGFRQMM..KRLPADQREELVEMFNQGH--------rdvnhqm.
A0A345AV77_9CAUD/2-82               .vy----ETLAEIIAVVSILIKFGH.D.D..............ILEDK.NLFIAFLNELGI-TINSKKVTAGNLFNLT..QDITTRQKEKLINEFNVGHAP------iykkl...
A0A2I7QXC0_9CAUD/6-90               ...NTTNEIALEIAAFASLLVKLGF.D.E..............CVENQ.KLFVEMCNETGIRTSTGKEFTQMSFRQMF..ARLPAKTAREVREIFSWGVDHQNESIL........
Q6U976_9CAUD/2-83                   nys----ENIKDIIATASLLIKFGC.E.D..............ILNKQ.ETFVSFLNELGFRSPTGEEFTRAGFRQMM..KRLPIEQREELIEMFNQGH--------rdvnhq..
Q6WHK8_BPKVM/10-94                  ...KSTPELALDIAAYASLLVKMGY.D.E..............CVTNQ.KLFVEMCNEAGFRTTTGKEFTQMSFRQMF..ARLPQGTKREVRESFSWGNVPQGESIL........
A0A023W6W7_9CAUD/1-95               ..m-NNVEFVREVMTVVSIVIKFGC.E.EpsqeamridpsyrgVIAKH.RHFVPFLVELGMKHPSGRELTVGNFRQVM..TELTIDEKEELIEEFNQGF--------rhiy....
E5EZ20_9CAUD/2-80                   .yn-----ILADIIATASILIKFGH.D.D..............ILENQ.RTFVAFLNELGFKTVEGRPITLTNLFNMT..QDITTREKDKLIEEFNIGHEP------iyr.....
I6YMP8_9CAUD/3-83                   .yn----ETIKEIISIASVLIKFGC.E.D..............ILNNQ.ELFVSFLNELGLKSPSGEEFTRAGFRQMM..KRLPADQREELVEMFNQGH--------rdinhq..
D9I6I4_9CAUD/1-80                   .my----EVLAEVIAVASILIKFGY.D.E..............ILENK.VLFVAFLNELKIKSHTGAPITVHTLTTMS..ENITTREQRQLIDEFNIGHEP------lyr.....
A0A0U4JUL8_9CAUD/2-81               ...NKNIDTVREIITVASILIKFSR.E.D..............IVENR.ANFIAFLNEIGV-THEGRKLNQNSFRKIV..SELTQEDKKTLIDEFNEGF----EGVY........
E5DQQ2_9CAUD/2-82                   ..n-AKLELIKDIIATVSLIIKLEV.DgE..............ILDSQ.QNLIDFLNEAGFRTVRGLEFTKMSFRQMI..GRMTDKERNEVLKEFSA----------qehye...
M1EAI1_9CAUD/1-81                   mtk---FEVAREVVTIASLLIKFGR.D.D..............IVDKR.DNFIAFINETMSADKNWKQLNQSSFRKII..SDLTAEEKGMLVEEFNEGF----EDI-y.......
A0A2I6UFL0_9CAUD/1-81               .ms--KFEIVSEIITMASLLIKFQR.E.D..............ILENR.EGFIAFLNECGIRNEFGRELNSANFRKMV..AELSDDEKKQLIQEFNVGH----ESVY........
A0A0B6VLD1_9CAUD/1-80               mtk---FEIISEIVTIASILIKTDC.D.D..............IMWKR.DHFIAFLNEAGIRNESGKELNGVSFNKLF..-DLTEDEREKLIEQFNEGY--------edvh....
A0A1B0VW24_9CAUD/1-81               mtk---FEVAREVVTIASLLIKFGR.D.D..............IVDKR.DNFIAFINETMSADKNWKQLNQSSFRKII..SDLTAEEKGMLVEEFNEGF----EDI-y.......
Q76YA4_9CAUD/2-82                   ..n-AKLELIKDIVATVSLIIKLEV.DgE..............ILDTQ.QNLIDFLNEAGFRTVRGLEFTKMSFRQMI..GRLTPAERIEILSEFSA----------qehye...
A0A411BIC7_9CAUD/3-84               ..n-TKVEILKDIVATASILVKYDC.E.D..............ILDTQ.TGFIDFLNELGFTTIRGKPLTQHNFKIML..KSMTDYQIKEALKEFDAGKI-------sdmi....
A0A2Z5ZCZ7_9CAUD/2-81               .lk---IEIVREIITVASILIKTSC.E.D..............ILEKR.ETFIAFLNELGLRNEHGRELNLANFKKMI..DGLTDEERLSLVEEFNEGF----EDI-y.......
A0A0A7HC73_9CAUD/1-81               mtk---FEIVSEIVTVTSILIKTDR.E.D..............ITMKR.DVFIAFLNELGLRNENGNELNNVSFNKLF..KSLSEDEIEQIIEQFNEGF--------edih....
A0A2D1GMI4_9CAUD/1-81               mtk---FEVAREVVTIASLLIKFGR.D.D..............IVDKR.DNFIAFINETMSADKNWKQLNQSSFRKII..SDLTAEEKGMLVEEFNEGF----EDI-y.......
#=GC SS_cons                        ...-SHHHHHHHHHHHHHHHHHTTT.H.H..............HHTSH.HHHHHHHHHHT--ESSSSE--HHHHHHHH..HSS-HHHHHHHHHHSHHHH----HHHH........
#=GC seq_cons                       .hp...hEllpEIlslASILIKFup.-.D..............Il-sc.ctFIuFLNElGlcs.pG+clspssFRphh..pcLos--+cpLlEEFNpGa................
//
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