GenomeNet

Database: Pfam
Entry: AviRa
LinkDB: AviRa
Original site: AviRa 
#=GF ID   AviRa
#=GF AC   PF11599.8
#=GF DE   RRNA methyltransferase AviRa
#=GF AU   Pollington J;0000-0002-8158-8998
#=GF SE   pdb_1o9g
#=GF GA   25.70 25.70;
#=GF TC   25.70 25.70;
#=GF NC   25.60 25.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   12742024
#=GF RT   Crystal structure of the avilamycin resistance-conferring
#=GF RT   methyltransferase AviRa from Streptomyces viridochromogenes. 
#=GF RA   Mosbacher TG, Bechthold A, Schulz GE; 
#=GF RL   J Mol Biol. 2003;329:147-157.
#=GF DR   INTERPRO; IPR024268;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family of proteins represents the methyltransferase AviRa
#=GF CC   from Streptomyces viridochromogenes. This protein mediates the
#=GF CC   resistance to the antibiotic avilamycin. AviRa methylates a
#=GF CC   specific guanine base within the peptidyl-transferase loop of
#=GF CC   the 23S ribosomal RNA [1].
#=GF SQ   58
#=GS A0A1Q9TV68_9ACTN/1-229   AC A0A1Q9TV68.1
#=GS G4HLL5_9BACL/1-235       AC G4HLL5.1
#=GS A0A1I1FU39_9FIRM/1-159   AC A0A1I1FU39.1
#=GS A0A1C6UV85_9ACTN/1-236   AC A0A1C6UV85.1
#=GS A0A1I4SM55_9PSEU/1-190   AC A0A1I4SM55.1
#=GS A0A238YKX9_9ACTN/1-234   AC A0A238YKX9.1
#=GS A0A1D8BVI5_9PSEU/1-238   AC A0A1D8BVI5.1
#=GS A0A094JRL9_9BACL/1-230   AC A0A094JRL9.1
#=GS A0A0N7JZF6_9PSEU/1-227   AC A0A0N7JZF6.1
#=GS A0A0M4QLT7_9PSEU/1-189   AC A0A0M4QLT7.1
#=GS A0A0M1NKN1_9BACL/1-235   AC A0A0M1NKN1.1
#=GS A0A1M6NSQ1_9ACTN/1-229   AC A0A1M6NSQ1.1
#=GS A0A0S4IXA1_BODSA/84-307  AC A0A0S4IXA1.1
#=GS A0A136PPG4_9ACTN/1-233   AC A0A136PPG4.1
#=GS A0A269W5I9_9BACL/1-233   AC A0A269W5I9.1
#=GS A0A2A2YZN3_9ACTN/1-234   AC A0A2A2YZN3.1
#=GS A0A060LXB2_9BACI/1-229   AC A0A060LXB2.1
#=GS A0A1I5JKD5_9ACTN/1-233   AC A0A1I5JKD5.1
#=GS A0A1Q4XMS3_9ACTN/1-229   AC A0A1Q4XMS3.1
#=GS M3CC20_STRMB/1-235       AC M3CC20.1
#=GS A0A0M8XW25_9ACTN/1-215   AC A0A0M8XW25.1
#=GS A0A1H9NFQ6_9ACTN/73-184  AC A0A1H9NFQ6.1
#=GS D2AWL7_STRRD/1-234       AC D2AWL7.1
#=GS A0A061P0B3_9BACL/7-236   AC A0A061P0B3.1
#=GS A0A061PHI3_9BACL/1-230   AC A0A061PHI3.1
#=GS R9KK57_9FIRM/2-90        AC R9KK57.1
#=GS A0A1B1ZMM7_9PSEU/1-185   AC A0A1B1ZMM7.1
#=GS D7AX50_NOCDD/1-231       AC D7AX50.1
#=GS A0A1Q3SWS9_9CHLR/12-249  AC A0A1Q3SWS9.1
#=GS A0A0N1NBN1_9ACTN/1-245   AC A0A0N1NBN1.1
#=GS A0A0M4QLW8_9PSEU/1-190   AC A0A0M4QLW8.1
#=GS L0EEW0_THECK/1-237       AC L0EEW0.1
#=GS A9KJB4_LACP7/1-224       AC A9KJB4.1
#=GS A0A223SEA5_9ACTN/1-232   AC A0A223SEA5.1
#=GS V9GBS0_9BACL/1-237       AC V9GBS0.1
#=GS C4RPB1_9ACTN/1-235       AC C4RPB1.1
#=GS A0A1R3UKD8_9ACTN/1-228   AC A0A1R3UKD8.1
#=GS G4L5U2_TETHN/1-235       AC G4L5U2.1
#=GS A0A1R1F2M5_9BACL/1-235   AC A0A1R1F2M5.1
#=GS A0A0J1DJF7_9FIRM/1-235   AC A0A0J1DJF7.1
#=GS D3EHE3_GEOS4/1-237       AC D3EHE3.1
#=GS A0A209DDY7_9BACL/1-229   AC A0A209DDY7.1
#=GS A0A1H3SVU9_9BACI/1-232   AC A0A1H3SVU9.1
#=GS A0A1H2ZGU3_9FIRM/1-225   AC A0A1H2ZGU3.1
#=GS A0A0C2G8J6_9ACTN/1-230   AC A0A0C2G8J6.1
#=GS A0A221W1A9_9PSEU/1-196   AC A0A221W1A9.1
#=GS A0A0S8HBM5_9BACT/12-228  AC A0A0S8HBM5.1
#=GS A0A1L7F5C0_9PSEU/1-196   AC A0A1L7F5C0.1
#=GS A0A1H8M9F5_9BACL/1-234   AC A0A1H8M9F5.1
#=GS A0A124H0X9_9ACTN/1-235   AC A0A124H0X9.1
#=GS A0A1V4EE19_9ACTN/1-234   AC A0A1V4EE19.1
#=GS D1BGB8_SANKS/1-223       AC D1BGB8.1
#=GS A0A1T5LV92_9CLOT/1-232   AC A0A1T5LV92.1
#=GS A0A091CDM9_9ENTE/1-233   AC A0A091CDM9.1
#=GS R9KC37_9FIRM/1-97        AC R9KC37.1
#=GS A0A1T4R189_9ACTN/1-230   AC A0A1T4R189.1
#=GS W2EII2_9ACTN/1-95        AC W2EII2.1
#=GS J7LF16_NOCAA/1-228       AC J7LF16.1
A0A1Q9TV68_9ACTN/1-229              .................................MGYRYAVERADHSALASGQVLRSAPGYPG..FPVRLASELFQR.GL.AHV--...--HD..SPVRLWDPCCGGGYL..L.TV.L..GLLHRDR..VS.HVRASDVDADAV.DLAARNLELLTA.SGLATREAELRRSARDFGRVAF..VERAEAAANLAAGL....AAMGGDL..PHDAAVADVFALGEPVG--.........ADLVVTDVPYGEMTRWSGGv...pGEDPVGALLASL...GRVL-PERAVVVVAARTRRIALPEGVRAL...ERVRVGNR..............................................................
G4HLL5_9BACL/1-235                  .................................MEYLYESAPRSFEDFASGRVLYNARGTTS..FPVRLASELAQR.CF.HLLEQ...KGAE..GPYTLYDPCCGGAYL..L.TV.V..GMLHGRR..LG.RIIGSDIQPDVL.PIAGKNLSLLRK.EGLEQRAEQIKSLYEQYGKPSH..RDALESATRLKELI....-AESAIE..EAACFQSDITDPKGGLDRAr.......gTHIVMTDLPYGDLVSWGGG.....SEDPVGRFFEQI...HPILDPARSVVAVISDKGQKLKHDRFRRL...QHMKIGKR..............................................................
A0A1I1FU39_9FIRM/1-159              .................................MNYLY-CPAGNYEDFASGRVIHGAKGIPN..FPVRLIAEIFGR.AM.AVSPK...KDH-..--LVVYDPCCGGAYS..L.AI.I..GFFYGRS..IE.KIYGSDISEDMI.ECARKNLEL---.----------------------..--------------....-------..-------------------.........-------------------.....------------...-----------------------------...--------tlsidgkempvtwednasvnelkeilplkvnmsmyggfeqvgsigqsisrddkqittefgdi
A0A1C6UV85_9ACTN/1-236              .................................MTYRFVAERHDYSDLASGAVLRSAPGHPA..FPVRLASEVFLR.AW.HAL--...-GQS..RPLTVWDPCCGGGYL..L.TV.L..GLLHRDK..IA.AVVASDIADGPL.RLARANLALLSA.EGMRRRTAELEDLARRFGRPSY..RESAEASRRLQALL....AQGGGDL..PYVVGAADALDQQQVSALLta....sppPGLVLTDLPYGEQTSWRGA....pQEAGLSGLLGTL...GSVL-PADAMVALTTRGRRVGLPAGVRAT...ARFKIGTR..............................................................
A0A1I4SM55_9PSEU/1-190              .................................MQYRHAPAADR---SALDAVLASAPGRPT..LPVRLTVELLGR.AR.EHLAS...RGAGnpGPVTVWDPCCGAGVS..L.TV.L..GLLCP-G..IA.TLAGTDADPAPL.DLARRNLALLAP.GGPAARASELDDLATRHGKESY..ADAAAAARELVPRS....RPQWMVA..PADAHDRAATRAALA-GIA.........PDVVLADLPHGRQTSWAGA.....TAAPA-------...-----------------------------...--------tpa...........................................................
A0A238YKX9_9ACTN/1-234              .................................MAYRYAVVRQNHEDLASGGVLHSAPGFPA..FPVRLASEMFQR.AL.ALLRE...DEA-..---TVWDPCCGSGYL..L.TV.L..GLLHHRQ..IT.AVLGTDVDTEAL.RLAAQNLSLLDE.AGLTARAADLDARAERWDKPSY..AAPARAARRLAREL....RTGRGGV..GHAVRPADVFDPEQLRR-Ald....garPGLVITDVPYGEQTDWRGP....gGASGVAGMLRAL...GAVL-PEEAVIAVAVRGRRLRLDDGLRAD...SSFRIGTR..............................................................
A0A1D8BVI5_9PSEU/1-238              .................................MPYRFAVEQTDHADLAGGAVLRSAPGLPA..FPVRLATELFAR.AA.ARLPG...G---..AELTMWDPLCGSGYL..L.TV.L..GLLHRGE..LG.AVLGSDVDERAT.EVATANLALLTS.AGLRARAGRLHEQAAEFDKPAY..ALAAEAAGRLAGLL....LAGGGDL..RAEVRRADALDPDALGGVVeg....fppVDLVLADLPYGEQTRWRGEh..gaAAEPQARLLRAL...RPNL-PDHAVLVLVDRSRKVVLPAGLRPL...ERFRIGTR..............................................................
A0A094JRL9_9BACL/1-230              .................................MKYHYEIEKKDYRDFASGRVLYNVPGSAP..FPVRLASEIFYR.AQ.SFLNE...EKN-..-GFKLYDPCCGSGYL..L.TV.L..GFLHASK..IR.EIAASDDDEKMV.AFARKNLSLLSF.AGLRRREEEIRKYVKEYGKPSH..IEALDSVQVLKAYL....--KKEPI..QITCFQRDITKPDENPVQR.........VQVIITDLPYGNLVSWRGN.....DENPVQSLFENL...WKAMDLNNSVAVIITGQKIKPEHEGFNRV...HHFKVGKR..............................................................
A0A0N7JZF6_9PSEU/1-227              .................................MQYRHAPAAN---HAALDAVLVSAPGRPT..LPVRLTVELAGR.AR.ERL--...--GP..GPVTVWDPCCGAGVS..L.AV.L..GLLCP-G..IA.VLAGTDADPAPL.GLARRNLGLLAP.GGLDDRASTLDGLAARHGKESC..AVAAAAARATIPAS....-----RP..EWRVGVADAGDPEA-VRTAlg....giePDLVLADLPHGRQTSWAGEp..gtGPPPEAGFLVAV...AEPL-HAEAVVVAVGRGRSVPLPPGVRPL...ERIRAGHR..............................................................
A0A0M4QLT7_9PSEU/1-189              .................................MQYRHAPAAN---HAALDAVLASAPGRPT..LPVRLTVELAGR.AR.VHL--...-PAD..APLTVWDPCCGAGAT..L.TV.L..GLLVP-G..LA.RLVGTDADPEPL.DLARRNLALLDP.GGLTARAADLEALAARHDKPSY..AEAATAVRTLVPAS....TPAWSVT..LADARDTAAVRSA--LAGAgpy...gtgPDLVLADLPHGHRTTWAAS.....PTRP--------...-----------------------------...--------gga...........................................................
A0A0M1NKN1_9BACL/1-235              .................................MEYIYESAQRSYEDFASGRVLYNAKGTTS..FPVRLASEIVQR.CF.HILEE...KGVE..GPYTLYDPCCGGGYL..L.TV.T..GLLHGLR..IR.RVVGSDIDAEVL.NIAGKNLSLLRE.EGLEQRAEQLKELLELYHKPSH..EEALQSAVRFRELN....-RQSSVK..EMECFQGDITDPHVSLNSCk.......gTHIVMTDLPYGDLVSWGGE.....SKEPVQALLDAL...HPILDPARSVVAVISDKGQKLKHDQFKRV...QHFKVGKR..............................................................
A0A1M6NSQ1_9ACTN/1-229              .................................MTYRYAVDRADGSVLASGHVLRSAPGFPG..FPVRLASELFQR.AA.VHVG-...---D..TRVRLWDPCCGSGYL..A.AV.L..GLLHRER..IA.SVRATDVDPDAV.ELAGRNLRLLTA.EGLAEREEELRRSARDFGRPAF..VERARDARALARGL....ARDGGDL..PHEAAVADVFSAVEPVA--.........ADLVVTDVPYGEMTRWSGAa...pEADPVGGLLAAL...GRVL-PPGAVIVVAARARRIALPEGVRAL...ERVKVGVR..............................................................
A0A0S4IXA1_BODSA/84-307             ..........emykrfpqeydllmakhdctqln-----------------------------..---RLFGDLMED.VR.QRLRS...AEH-..-GLRMIDLGCGTGRL..L.CAaL..SEAAARRipLS.LLIGYDKEAAML.RIALANMQKQ-Q.QQQQRRESEPDAVDSREATETI..TEALQSIDRAEDWS....SSSSGTT..TTCLRPFDFLHVRQGALHAphp...thhIAVCAWSLSYVMRSCWGGD....rWHQELRDTVDAI...VASVVDGGAVVII----------------...--------etlgngcetptrrnvm..............................................
A0A136PPG4_9ACTN/1-233              .................................MTYRFATERPDYSDLASGAVLRSAPGHPA..FPVRLASEMFLR.AW.HALG-...---R..PRVTVWDPCCGSGYL..L.TV.L..GLLHRER..IA.GIVASDVADGPL.RLARANLGLLSA.DGLQDRAAELDELADRFQRPAH..RTAAEAARRLRAQL....--TPGDP..ATVVGRADALVPEQVADLLaa....sgpPDLVLTDVPYGEQTTWQGA....dPAAGLPGLLDSL...AGAL-PAETMVALATRGRRVPLPAGTRTA...ARFKIGTR..............................................................
A0A269W5I9_9BACL/1-233              .................................MEYIYESAQRSYEDFASGRVLYNARGTTS..FPVRLASEIVQR.CL.RMLED...RGNE..GPYTLFDPCCGGGYL..L.TV.A..GLLHGQR..FK.QVIGSDVNAGVL.ELAGNNLSLLTP.EGMQRREKQIKELIQLYDKPSH..HEALQSVARLEQLL....-DRSAIE..EVRCFQGDITNWQEPFDLK.........ANLVLTDLPYGQIVSWNGD.....SADPVHDFFEHV...YRLLEPGRAVVAVIADKSQKLRHDRFTKI...QGFKVGKR..............................................................
A0A2A2YZN3_9ACTN/1-234              .................................MPYRHATERVDSTDLACGVVLHSAPGYPA..FPVRLAVEIFLR.GL.DHL--...PDD-..GPVTLWDPCCGSGYL..V.TV.L..GLLQRRS..LR.RVIASDVDPEPV.GLARKNLALLTP.EGLAARERERREQSERFAKPSY..LEAADAARRLRERL....TADGGGL..PCTVETADVFDAEALARVVsg.....spPDLVVTDLPYGERTQWAGE....vPGEPVTGMLRSL...ASVL-PPHAVIAVTDRARKIPVAP-VRPL...ERLKIGTR..............................................................
A0A060LXB2_9BACI/1-229              .................................MQFTYETIKRDFSDFSSGRVLYNAPGSTG..FPIRLTSEIFQI.SR.SYLQK...PSQ-..--LNVYDPCCGGAHL..L.TG.I..GFLHGGS..IQ.TLYGSDSNETII.ETGQSNLRLLTY.EGLAQRKRKLEKDYLLFNKSAH..AEALKSVDRLKSYL....-DKTGEV..KGEIFQFNIASKDVPKLEE.........IHIVMTDLPYGELVSWDTN.....VLSPVKQMLQNV...YSVL-AHDGVVAVVSDKFTLIEHPLFRRL...KVLKHGKR..............................................................
A0A1I5JKD5_9ACTN/1-233              .................................MAYRYAVVRENYEDLASGGVLHSAPGFPA..FPVRLASEMFQR.AL.AMRQD...H---..-AAMVWDPCCGSGYM..L.TV.L..GLLHPGQ..IT.AVVGTDIDPAAL.RLAGQNLALLDE.AGLSARAADLDAQAERWDKPSY..AAAAQAARRLARRL....-PSGQGP..APHLHQADVFDPRQLRQALdg.....rrPGLVITDVPYGEQTGWRGP....gGASGTAGMLRAL...GELL-SEDAVIAVAVRGRKLRLDDGPRAD...ATFRIGTR..............................................................
A0A1Q4XMS3_9ACTN/1-229              .................................MSYRYAVERTDHSVLASGHVLRSAPGFPG..FPVRLASELFQR.AM.VHT--...--GR..EAVRLWDPCCGSGYL..A.TV.L..GFLHRDR..LT.HVRASDVDADAV.ALAERNLRLLTG.EGLVEREEELRRSARDFGRVTF..VERAEAARDLAAGL....AAMGGDL..PSETAVADVFSLTEPVD--.........ADLVVTDVPYGEMTRWAGAv...pGEDPMRGFLRSL...GRVL-PERAVAVVTARTRRVALPEGVRAL...ERVRVGNR..............................................................
M3CC20_STRMB/1-235                  ...............................ms-SYRHAVERSDSSDLACGVVLHSAPGYPA..FPVRLATEIFLR.AQ.ARL--...PDD-..GPVTLWDPCCGSGYL..L.TV.L..GLLHRRA..LR.RVIASDVDPAPL.ELAAKNLALLSP.GGLAAREAERREQSERFAKPAY..QESADAARRLRDRL....EADGGAL..PYAVGAADVFDPRSLSAVVag.....aaPDVVLTDLPYGERTHWDGA....vPGQPVTGMLRSL...ASVL-PAHAVIAVTDRSRKIPVAP-VPAL...ERLKIGTR..............................................................
A0A0M8XW25_9ACTN/1-215              .................................--------------MASGNVLRSAPGFPG..FPVRLASELFQR.GL.AHV--...--PR..EPVRMWDPCCGSGYL..V.TV.L..GLLHRDR..IV.HARATDVDPDAV.ALAARNLALLTR.EGLAEREEELRRSALDFGRAEF..VGRAETAGALAAGL....ASMGGDL..PHETGVADVFTLSEPVE--.........ADLVVTDVPYGDLTHWRGEa...pGDDPMAALLASL...GRVL-PPHAVIVVTARTRRVVLPPGVRAL...ERVKVGNR..............................................................
A0A1H9NFQ6_9ACTN/73-184             ...................vrvvvepgvfvprr-----------------------------..-----RTELMVA.TA.VELGA...ARPE..GPLVLLDLCCGSGAV..A.VA.VthGLGRRGR..TV.EVTAADLDDAAV.RCAARNL-----.----------------------..--------------....-------..-------------------.........-------------------.....------------...-----------------------------...--------pgarvlrsdlfadlpvdlqgrvdlltanvpy...............................
D2AWL7_STRRD/1-234                  ................................m--YRHATVRGDYEDLASGAVLHSAPGFPA..FPVRLASEAFQR.AL.ALR--...-GGG..GPATVWDPCCGSGYL..L.TV.I..GLLHRGR..IQ.ALLASDVSDDAL.RLARANLDLLGQ.AGLSARAGVLREKAERFAKPSY..AAAAEAAGRIGRML....AAGGGDV..PHDVRRADVFDPGQLAEAAag.....yaPDIVVTDVPYGEQTTWQGP....gGDSGVPGMLAAL...APVL-TERAVVVVTARGRKVPLGGRIRAR...ESFKVGTR..............................................................
A0A061P0B3_9BACL/7-236              .................................MNYKYETENKDYRDFASGRVLLNAKKTTA..FPIRMASEIMQH.CI.ASLEK...KES-..--LTLYDPCCGGAHL..L.TA.M..GFIHGKA..IK.AIYGSDFDRDVI.EVATTNLSLLTD.DGLIKRENQLSSLFNTYGKESH..KEALESVGRLRSMS....-AQMTSP..IISSFTWDITGGPPPVNEK.........VDIVITDIPYGNTVGWQTT.....SSDPVQDLLGHL...ELIMNKEDSIIAIVSEKKETITHDRFEKV...KTMKHGKR..............................................................
A0A061PHI3_9BACL/1-230              .................................MQFLYETEAGDYRDFASGRVLRNAPGTTA..FPVRLTSEILFR.CR.ALIGK...KTE-..--LTIYDPCCGGAHM..L.TA.A..GFLHGRS..IT.TIVGSDVNSSVV.PIAKSNVSLLTR.EGLEDRKQQLQAFFDEFQKSAH..REALESIERLEQLQ....QKAGPFH..SLQAFDHDITT-SPPSVEG.........VNIIIADLPYGNTVDWQTT.....EDEPLHQMLQNI...YETLDPDQSVVALISDKKQQTEHRYYERV...KALKHGKR..............................................................
R9KK57_9FIRM/2-90                   ..............................fsh-----------------------------..------------.--.-----...----..---------------..-.--.-..-------..--.------------.------------.----------------------..--------------....-----DV..SAEIFEADCTKALPQVF--.........PDIIITDVPYGNLVEWDSG.....ELIAIDLMLEQL...WTIS-HENTILAICMNKKQKINCSKWKRL...EKQSIGKR..............................................................
A0A1B1ZMM7_9PSEU/1-185              .................................MQYRHAPAAN---HAALDAALASAPGRPT..LPVRLTVELFGR.AR.EHV--...PGAR..GTLTVWDPCCGAGGT..L.AV.L..GLLCA-G..VH.RLAGSDADPRPL.DLARRNLGLLGP.GGLATRADELEELAARHGKDAY..AGAAAAVRALVPRS....-----RP..EWSVGVADAGDPA--AVRAalg...gavPDMVLADLPHDRQTTWSGL.....------------...-----------------------------...--------ppapgag.......................................................
D7AX50_NOCDD/1-231                  .................................MGYRYAVERTDHSALAGGHVLRSAPGFPG..FPVRLASELFQR.AM.VHT--...--GG..EPVRLWDPCCGSGYL..A.TV.L..GLLHRDL..LT.GVRATDVDADAV.ALAARNLRLLTA.EGLAEREEELRRSARDFGRVAF..VERAEAARDLAAGL....AAQGGDL..PHEAAVADVFSLEEGVE--.........ADLVVTDVPYGEMTRWEGNvp.ggAGEPMRGLLASL...GRVL-PEHAVVVVTARTRRVSLPEGVRAL...ERVKVGNR..............................................................
A0A1Q3SWS9_9CHLR/12-249             ..............................ser-------NRLDFSILASGQVIYSAPGRTA..FPVRLAVDIFQK.VV.HYRTK...KGGS..TSFTLYDPCCGSGYL..L.VT.L..AFLNWKY..IT.KIIGSDIDPNAL.QIAQHNFSLLTP.DGINLRIEQLSQLVSSYGKSSH..SETLENARLFSEKV....NNFQGEHnfDGYLFQADATKSEDLIKNLeg.....qkVNLVITDIPYGNRTSWMGEt..peNLPSIELMLSSL...LPIL-SKDGIVALVSPKRQSFNYSGYKRL...TKYLIGKR..............................................................
A0A0N1NBN1_9ACTN/1-245              .................................MPYRHATERSDGSDFASGFVLHSAPNHPA..FPVRLATELFLR.AL.EHLPTptgPGSG..PGVTLWDPCCGSGHL..A.TV.L..GWCHRRT..IG.RVVASDVDGETL.SLARKNLRLLSP.EGLLDRERERLELSVRFDKPAY..AEAARAAHRLAGRL....AEDGGAL..PWSAGRADVFDPASLSALLasaglrgaaPDVVVMDVPYGERTHWGGQ....aPERPVPALLRSL...AAVL-PPHAVIAVADRARKIPVAP-LRPL...ERLRIGTR..............................................................
A0A0M4QLW8_9PSEU/1-190              .................................MQYRHAPAAN---HAALDAVLASAPGRPT..LPVRLTVELAGR.AR.AHL--...-SAD..APLTVWDPCCGAGVT..L.TV.L..GLLEV-G..IT.RLVGTDADPEPL.DLARRNLALLDP.GGLTARAADLDALAARHDKPSY..ADAATAARTLVPAStpawSVAVADA..RDTAAVRGVLAVASPDDTG.........PDLVLADLPHGIRTTWAAS.....PTRP--------...-----------------------------...--------gaad..........................................................
L0EEW0_THECK/1-237                  .................................MEYRFATDEPR-GHFASGRVLYNAKGAAP..FPVRLADEIVQR.CF.HYLEE...RGHS..GPYAIYDPCCGSGYL..L.TV.I..GLLHGAQ..IR.AVFASDIDESML.ETARRNLSLLTA.EGMRARIEQLRELYEQYGKPSH..AEALESAAMLDGYR....-ACGTVE..SIEMFPADITVGSPEAVRDsg....fcpVNIVIADLPYGHLTGWQSG.....SADPAARMLDSL...FPLLRPGASVIALISDKSHKLRHERYRRI...ALLKAGKR..............................................................
A9KJB4_LACP7/1-224                  .................................MEYKY-TKNDNYEDFASGRVLYHVGGEPT..FPVRLALEIYER.CL.QYSIK...KAE-..--ISLYDCCCGGAYM..L.SI.L..GLLKSNT..IA.NLYGSDINSESI.QLANDNLGLLTK.SGINKRRDELKALYQTYKKASH..IDALHSIDRIEELL....---TREI..KTYLFKGNVLEVCDLPFT-.........PDIIITDVPYGNMVEWEEG.....SG-GINQMMNAL...SAVC-GSDTIICVCMDKKQKIHNDIFQRL...ERQLVGKR..............................................................
A0A223SEA5_9ACTN/1-232              .................................MTYRYATERADRSDLATGHVLRSAPGHPG..FPVRLADELFQR.AA.SHL--...--GS..DPLRLWDPCCGSGYL..A.TV.L..GLLHRDR..LA.HILATDVDPDAL.GIAARNLDLLTV.DGLAARERELRAGAAEFGKPSF..LERADAARRLADGL....AGLGGDL..PHTVRPGDAFVPDPPEH-P.........VDLVVTDVPYGDLTHWSGDvp.apGTDPLPALLHSL...ASVL-PDHAVLAVTARARKIPLPDGVRAL...ERVRVGNR..............................................................
V9GBS0_9BACL/1-237                  .................................MEYLYESVQRSYEDYASGRVLYNAHGTTS..FPVRLASEIAQR.CF.HILEQ...KGAG..GPYSLYDPCCGGAYL..L.TV.L..GLMHGQR..FS.SVIGSDVNPEVL.AIANKNLSLLTH.QGLDHRIGQLQELFERYHKPSH..QEALQSAARLKVLL....-DRSRLE..DASCYPADITDSQSQAALNrp.....agIHMVITDLPYGDIVSWHGG.....SGEPVREFFEQI...HPMLDPGHSVVAVIADKGQKLRHDRFKRL...QQFKAGKR..............................................................
C4RPB1_9ACTN/1-235                  .................................MTYRHETVRGAYGDLASGAVLRSAPGFPA..FPVRLASEVLQT.AL.ELR--...P-TS..APATVWDPCCGSGYL..L.TV.L..ALLHRPS..LA.GLLASDVDEAAL.DLARANLGLLTG.AGLDTRARELAQRAEAFDKPHY..AEAAAAAHRLRARL....DAAGGPL..PYAVRRADVFDRVALTEAVag.....mtPDLVVTDLPYGEQTSWQGE....rAGEGLPGMLTRV...ASVL-PPTGVLAVVLRGRKVPPVGEVRPR...RRLRVGTR..............................................................
A0A1R3UKD8_9ACTN/1-228              .................................MSYRYATERTDHSALASGQVLRSAPGFPG..FPVRLASELLQR.AM.VHLGE...DRA-..---RLWDPCCGSGYL..V.TV.L..GLLHRDL..LT.HVRASDVDADAV.AIATRNLELLTA.EGLAERERELRRSALDFGRVTY..VERAEAARDLAAGL....AATGGDL..PHESAVADVFTLTEPVD--.........ADLVVTDVPYGEMTRWEGE....tPQDPVPGLLSSM...GRVL-PERSVVVMTARTRRVQLPEGVRAL...ERVKVGNR..............................................................
G4L5U2_TETHN/1-235                  .................................MKFKFEPIKKDYSDFSSDKLLVNAPRTPA..FPVRVASEIMAR.SL.SFLNS...ADG-..--LTLYDPCCGGGHL..L.TV.L..GFCYSKN..LK.NIYGSDIDTKAL.EYAQKNLNLLTP.EGLSKKKKDLQYNDEKQDEKTQ..LEALNSANRLEKQL...fHTTYPKK..DIQCFHWDITRKKPPHLKN.........VNIVITDLPYGKMSDWQGEg..ttQNNPNKQMLNNI...YQTLDLNNSIVTIICNKQEKINHQKFEQV...KRLKHGKR..............................................................
A0A1R1F2M5_9BACL/1-235              .................................MEYLYETKADSYEDYASGRVLYNAPGVTS..FPVRLGSEIVQR.CF.GILED...RGIS..GPYTLYDPCCGGAYL..L.TI.T..GLLHGTK..VR.RMYASDVDPNAL.SVAGKNLALLTK.QGLTERELQLRELYGNYGKPSH..KEALESLARLESAV....-SGLTLD..ASVVFQDNITEPHHLDHVDq.......pIHLVLTDLPYGDLVSWESG.....DADPVSALFEHI...YPLLSSEGAVVAMIADKSQKLGHARYKRL...QHFKVGKR..............................................................
A0A0J1DJF7_9FIRM/1-235              .................................MKYRFEIEAKNYEDFASGRVLYNRKGATA..FPVRLGSEIIQR.CL.ERVRK...ARGK..VPLTIYDPCCGGAYL..L.TT.I..ALLHGRE..FS.KLYASDVDGEIL.ELAKANLALLTP.AGMARRIAELEELFALYGKDSH..REALASASRLGELV....-EHTAHL..EIHCMEIDVLRPGLAGKIAp......qsIDIVITDVPYGSIASWSQD.....ITDPIGVMLSNL...RPAV-RDQGVVALVTTKQQKVQAQGFKRL...EGFKIGKR..............................................................
D3EHE3_GEOS4/1-237                  .................................MEYIYESAQRSYEDFASGRVLYNAQGTTS..FPVRLASEIAQR.CF.HILEE...KGVQ..GPYTLYDPCCGGAYL..L.TV.V..GLLHGRR..IR.RVIGSDINAEVL.GIAGKNLSLLRE.EGLEQRTEQLKELLALYHKPSH..QDALESADRLRELI....-RMSRLE..ETFCFQADITQPQPEESLAsc.....kgTQIVMTDLPYGDMVSWSGG.....SQEPVEDFFNGI...HAILDPVRSVVAVISDKGQKLKHDRFKRI...QHLKIGKR..............................................................
A0A209DDY7_9BACL/1-229              .................................MMYQFETEKKDYRDFASGRVLHHAPNTTA..FPVRLGKEIMSR.CL.AQLDS...KQN-..--LKIYDPCCGGAYL..L.TM.L..GFNYGDQ..IS.EIYGSDIDEGVL.EHARRNLSLLTE.EGLTLRELDLQRDFEQYGKDSH..REALESVERLRMLN....--RALIR..TTEVFSLDISGDVRPPLTN.........LNVVIADLPYGQMTSWGGQ.....QADPVRSMLHNI...YPILNRKNAIVAIICDKKQRAEHEQFERR...GTLNHGKR..............................................................
A0A1H3SVU9_9BACI/1-232              .................................MKFKYEVEKKDHRDFSSGRVLINAPQTPA..FPVRIASEIMSR.CL.SYINS...NDC-..--ISIYDPCCGGAHL..L.TV.I..GFLYREK..IE.RVYGTEIDIKAV.GYAKRNLNLLTS.NGLFQRKKNILQNYNKFGKVSH..LEALQSVKRLISTT....LDSNHIK..DIQCLDWDITSSKPPVFRN.........INIVITDLPYGNMAIWKGT....kNMNPIEQMLKNV...YYTLDLNNAVVSIICDKNQKVEHEWFEQV...KRLKHGKR..............................................................
A0A1H2ZGU3_9FIRM/1-225              .................................MEYRY-GKNINYEDFSSGRVLYHISGMTN..FPVRLAQEIYGR.CI.EYSRK...KNN-..--ICLYDCCCGGGYL..V.TV.L..GFLNQNT..IS.RIIGSDIDLELL.EVAKKNLSLLSE.EGMDNRIKEIDNMIVNYNKESH..AMAKESAIILRSMI....---KTPI..QYEVFQADAL-KEIKLEIK.........PDIIITDVPYDQLVDWKGS.....GEGLVNRLLDVL...YGAC-TSDTIIGLSMNKKQKVKNDKFIKL...ERQKIGKR..............................................................
A0A0C2G8J6_9ACTN/1-230              .................................MAYRYATERRDHSDLASGNVLRSAPGHPG..FPVRLADELFQR.AA.AHL--...--PA..APVSLWDPCCGSGHL..A.TA.V..GLLHRAR..LC.RLLATDTDPAAL.SIAERNLALLTL.SGLAERESGLRDDAAAFGKPAL..LERADTAARLAERL....RKSGGDL..DRTVRAGDAFDPVAPEH-R.........VDLVLTDVPYGGLTAFAGAv...pAGEPVPALMRAL...AAVV-PAHAVLAVTARTRKVPLPEGARAL...ERIRVGNR..............................................................
A0A221W1A9_9PSEU/1-196              .................................MSYRFAVERTDHADLAGGAVLRSAPGFPG..FPVRLAVELFAR.AR.AWLPD...RSE-..--LTLWDPLCGSGYL..L.TV.L..GLLHRHE..LG.AVLASDVDPRAC.ALAAENLGLLGE.AGLRARSAHLRDLAERFDKPSH..AEAAEAADRLTGLL....RAGGGDL..PAVVRRADATNPTETRAATag....lppVDLVITDLPYGEQTAWQGQ.....AG----------...-----------------------------...--------aataaap.......................................................
A0A0S8HBM5_9BACT/12-228             ............................fspql--------------FAHGRVLYRYPGSDAcrFSPRLSYSLIEH.IP.TS---...PSAE..RPSVLWDPFCGTGMI..V.SI.A..CLFFPKK..FQ.TIIASDIAPEAV.ECAGKNLSLVSSvEAANKRLKYIRGLRGMHAKACRrwGEVAEYLEALMPLI...eQTQRRAP..TLRAFTASAFALRPGIEGD.........LHF-VGDVPYGRTSHVGGG.....RQ--LTALLDRI...AEAY-PNA---------------------...--------tmrfvmprdageavlretttva........................................
A0A1L7F5C0_9PSEU/1-196              .................................MSYRFAVERTDHADLASGSVLRSAPGFPA..FPVRPAVELFAR.AR.AWLPD...RRE-..--LTLWDPLCGSGYL..L.TV.L..GLLYRRE..LG.TVLASDIDPRAC.ELATENLAMLST.AGLRARATRLRELAGQFDKPSY..AEAAEAAGRLDGLL....RVGGGDL..PALIRRTDATDPAETQAAVag....lppVDLVITDLPYGEQTDWQGRa...eATD---------...-----------------------------...--------ptaa..........................................................
A0A1H8M9F5_9BACL/1-234              .................................MEYKYERNKENYEDFASGRVLYNAQGTTA..FPVRLASEIVQR.CF.QVLEA...KGSK..GPYSIYDPCCGGAYL..L.TV.I..GLLHNDR..IQ.RIYASDINADVL.GIAEKNLSLLTV.TGINKRKEQIKEYIRLYNKASH..ISALESAERLSSCI....-AGSNME..SVTAFQSDVTASDNKVIHN........rVNIVITDLPYGDIVTWRSD.....SSDPLVDFFDSV...YDLLEPTHSVLAVIADKSQKLKHEKFRRI...EFVKIGKR..............................................................
A0A124H0X9_9ACTN/1-235              ...............................ms-AYRHAVERIDSSDLACGVVLHSAPGYPA..FPVRLATEIFQR.AV.ARL--...P-GD..GPVTLWDPCCGSGYL..L.TV.L..GLLHRRS..LR.QVIASDVDPAPL.ELAAKNLALLSP.AGLTARELERREQSERFGKPSY..LEAAQAARRLRERL....TAEGGAL..PCAIRTADVFDPRALS--Avia...gsaPDVVLTDLPYGERTHWEGQ....vPGQPVAGLLRSL...ASAL-PAHAVIAVTDRSRKIPVAP-VRAL...ERLKIGTR..............................................................
A0A1V4EE19_9ACTN/1-234              .................................MTYRHATVRGDYADLASGAVLHSAPGFPA..FPVRLASEMFQR.AM.ELR--...--GG..GLATVWDPCCGSGYL..L.TV.I..GLLHRTR..IS.AVLASDIDPAAV.GIAERNLGLLTR.TGLAARAAHLTEQAERWGRASY..TAAAEAAHRIATGL....SSDGGDL..PHAVHQADVFDADRLRQVLgg.....rrPDVVVTDVPYGEQTSWHGP....dGADGAVGMLNTL...GTVL-GENALIAVAVRGRKAPRADRLRTC...ATFKIGTR..............................................................
D1BGB8_SANKS/1-223                  .................................MKFEHAP-QASYEDVGGGQVLHSAPGFPG..FPARLAVELFER.AR.VLVGR...----..ERVGLWDPMCGAGGI..L.TS.V..ALLRPDA..LT.RVLASDVDEGAL.ELARKNLLLTTV.PGLEARRAELVE------RGAA..AGRVASADRLLARV....-AGLPAP..PASLARADVTDPSSVAGLDl......dgVDVVMADLPYGTQTDWAST.....STTPTAQALEVL...RDAL-PDGAVVVLSTTEREHLR-GLPDAT...RSFKHGHR..............................................................
A0A1T5LV92_9CLOT/1-232              .................................MKYKFETNKRDYSDFSSGRVLYYAANTTA..FPVRLASEVIQR.SF.DILEK...KGAH..GPFKIYDPCCGGGFL..L.TT.I..GFLYHDL..IS.ELIATDYDDKVL.EIAKKNLSLLSK.KGLDRRKEEIKGYIKAFGKESH..MQALKSVDYLETLI....--KKEAI..KIVCMQRDIADLSDFPIKG.........VNIIITDIPYGIIVDWRGG.....RKDPIQNLFENS...YNALDKKRSVLVIIADKKSKLKHKSFERT...QYFKLGKR..............................................................
A0A091CDM9_9ENTE/1-233              .................................MKFKFETLKKDYSDFSSDKVLVNAPRTPA..FPVRIASEIMAR.CL.SFLKS...TDH-..--LTIYDPCCGGAHL..L.TV.L..GFIYSTN..LT.KIYGTDIDKSAL.TYAQKNLNLLTD.ETLNQKIKTLQSVNKSQEEQTQ.sAEVLHSAKRLAALL...lDTKAPQK..EVQCFPWDIT-EGPPFFKK.........VNIVITDLPYGNMAHWQGD....iREQPAKLLLDHI...YQTLDLNNSVVAIICNKNERIAHQNFIQV...NRLKHGKR..............................................................
R9KC37_9FIRM/1-97                   .................................MEYFY-CPKDNFKDFASGQVLYGGGGIPN..FPIRLLIELYCR.AK.SYLPK...SKD-..--ITIYDPCCGGGYA..L.TV.L..GFFHNHD..IK.KMYGSDINPNMV.SHAKKML-----.----------------------..--------------....-------..-------------------.........-------------------.....------------...-----------------------------...--------hy............................................................
A0A1T4R189_9ACTN/1-230              .................................MAYRHVTERADFTDLASGQVLRSAPGFPG..FPVRLASELLQR.AL.AHL--...--PQ..RPVSLWDPCCGSGYL..A.TV.L..GLSHRDR..LS.HVRVGDVDSDAV.ALAARNLELLTV.EGLAARERELRAHAEEYGRPSF..LERARAAARLADGL....VALGGDL..PHAVEVADVFAPRRPRP-A.........VDVVVTDVPYGDLTHWAGDr...pAGEPVTGLLRTL...AGVL-EDHAVLVVTARTRKIALPEGVRPL...ERVRVGNR..............................................................
W2EII2_9ACTN/1-95                   ..............................lpa-----------------------------..------------.--.-----...----..---------------..-.--.-..-------..--.------------.------------.----------------------..--------------....-------..--EARRADVFDAGGLREVLgg.....rrPGVVVTDVPYGEQTSWLGP....dGESGAAGMLRTL...GAVL-PEGAVIAVAVRGRRPPRADGADGLvprGSFKIGTR..............................................................
J7LF16_NOCAA/1-228                  .................................MSYRYATERADHSALASGQVLRSAPGYPG..FPVRLADELLQR.AM.VHV--...--EG..DRVRLWDPCCGSGYL..V.TV.L..GLLHRDL..LT.HVRASDVSSDAV.GIAARNLELLTA.EGLAERERELRRSARDFGRVAF..VERAEAARDLAAGL....AAMGGDL..PHESAVADVFSLTEPVD--.........ADLVITDVPYGEMTHWDGE....aPEDPVRGLLASM...GRVL-PRNSVVVVTARTRRVRLPEGVRAL...ERVKVGNR..............................................................
#=GC seq_cons                       .................................MpY+atstppsapDhASGpVLhsAPGhPu..FPVRLAoElhpR.uh.shL......ts...tslolaDPCCGuGYL..L.TV.L..GLLHtpp..ls.plhuSDlDsssl.plAp+NLuLLo..pGLstRtpcLcp.hppasKsoa..tEAhcuAcRLtshl.....stsssh..shpshpuDlhsspt.hthh.........sclVlTDlPYGchosWpGs.....stpPltshLpsl...htsL.stpuVlslhsctpph.h.tthctl...pph+lGpR..............................................................
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