#=GF ID   BLI1
#=GF AC   PF17324.3
#=GF DE   BLOC-1 interactor 1
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   PRODOM:PD073250
#=GF GA   26.90 26.90;
#=GF TC   27.20 33.40;
#=GF NC   26.50 26.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   23547030
#=GF RT   The BLOC-1 complex promotes endosomal maturation by recruiting
#=GF RT   the Rab5 GTPase-activating protein Msb3.
#=GF RA   John Peter AT, Lachmann J, Rana M, Bunge M, Cabrera M, Ungermann
#=GF RA   C;
#=GF RL   J Cell Biol. 2013;201:97-111.
#=GF DR   INTERPRO; IPR020491;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   In yeast BLOC-1 consists of six subunits localised to the
#=GF CC   endosomes. In the absence of BLOC-1 subunits, the balance
#=GF CC   between recycling and degradation of selected cargoes is
#=GF CC   impaired. This family contains BLI1 (BlOC-1 interactor 1)
#=GF CC   protein, a subunit of the BLOC-1 complex which mediates
#=GF CC   endosomal maturation [1].
#=GF SQ   25
#=GS A0A0C7MZ07_9SACH/1-108  AC A0A0C7MZ07.1
#=GS G0VJC9_NAUCC/7-117      AC G0VJC9.1
#=GS BLI1_ASHGO/1-108        AC Q75DG4.1
#=GS BLI1_VANPO/1-111        AC A7TLL0.1
#=GS G0W7G6_NAUDC/10-106     AC G0W7G6.1
#=GS S6EXP5_ZYGB2/1-111      AC S6EXP5.1
#=GS A0A1G4J6F1_9SACH/1-110  AC A0A1G4J6F1.1
#=GS A0A1G4JVM3_9SACH/1-108  AC A0A1G4JVM3.1
#=GS BLI1_ZYGRC/1-111        AC C5E4I6.1
#=GS A0A120K1R2_9SACH/1-108  AC A0A120K1R2.1
#=GS G8JS86_ERECY/1-107      AC G8JS86.1
#=GS G8ZQ95_TORDC/1-111      AC G8ZQ95.1
#=GS J8TYM2_SACK1/1-110      AC J8TYM2.1
#=GS A0A1G4MKZ9_LACFM/1-108  AC A0A1G4MKZ9.1
#=GS H2B003_KAZAF/1-107      AC H2B003.1
#=GS BLI1_KLULA/1-103        AC Q6CP44.1
#=GS BLI1_LACTC/6-113        AC C5DGT3.1
#=GS A0A1X7QWE1_9SACH/8-115  AC A0A1X7QWE1.1
#=GS G8BXX4_TETPH/1-111      AC G8BXX4.1
#=GS J7RFQ3_KAZNA/91-165     AC J7RFQ3.1
#=GS BLI1_YEAST/1-110        AC P35727.1
#=GS I2H839_TETBL/1-108      AC I2H839.1
#=GS W0T9V8_KLUMD/1-101      AC W0T9V8.1
#=GS BLI1_CANGA/1-103        AC Q6FLQ1.1
#=GS A0A1G4JFU8_9SACH/1-108  AC A0A1G4JFU8.1
A0A0C7MZ07_9SACH/1-108             ...........mk----ETQIRKYVEHCNNSLQEIVDLQSAQAIKEFQTKTEENFQRLDDAKSRFK.T-DTQSIEE..FKALKSEFSTKIDDLEKSIDYYEKLADEIQEFLVECEVKEKLAMKRLS-q...............
G0VJC9_NAUCC/7-117                 ............g-TNNARSMQQNVENCMKQVQEFVDTETTKSISLFSAKTRANEVWLQEITEKYS.TIPDDELKK..LDALKKDYLEKLGELTKKVEYFEQMCDELEEFQNELEIKTKVNTNRQSR................
BLI1_ASHGO/1-108                   ............m---NEKQLRQQLDRCLDHVQEHVDMLSARAISKLSGDAVANHEWLSELSGRYP.TRSAEELQQ..FRELKDGYVKKLDTLETEVKYLEDLGQELAEFQNELSVKLQ--------rirrnsy.........
BLI1_VANPO/1-111                   .............MREQERKLSNGIEHCLSKTQEYVDMESAKAISIFSSKVNSNGRWLAEISGKYE.LKESGELEA..FRLLKEDHVKMLDQLEGKIEYYEKLLDELTEFTSEIEIKRKIEKNRRSR................
G0W7G6_NAUDC/10-106                ..........sgg---KNKFLQTKVEACVNSLQELLDTEAARSISTFAGKTGSNKVWLEELSAEYK.LKPDRKLDA..IGELYAQQLKQLDDLEEKS------------------------------fimkiyvmklksfkkn
S6EXP5_ZYGB2/1-111                 .............MREQESTLHQDVEHCVEALQDYLNTELAKAVSVFSKKAGENETWLEEIRTKFQ.LKDEDELQA..IKTLKEQSLTRLEVLEKKVDYYEELCDELEEFQNELEVKTKLEQNRRSR................
A0A1G4J6F1_9SACH/1-110             ............m---NEKALKKELEACIVQLQEIANVESAEAISGFEGTIERNYKKLEELKTKFI.LKNGDEDRDraMDVLD-QFDEKLSALETVVEYHEKLADEIDEVLREFKVKKELAENRLSR................
A0A1G4JVM3_9SACH/1-108             ...........mk----EGQLKRQVESCTNQLQGNVDLQSAQAITTFQMKSEDNFRRLDDLKDKFQ.TN-YQAIED..YKLVKTQFRTKIEDFEKSLEYHEKLADEIEEFLAESNVKKKVAIKRQSR................
BLI1_ZYGRC/1-111                   .............MRDQERTLNQDVERCINVLQDFLDTGSAKAISVFSNKTSENEDWLEEIRVKYR.IKDNDELQA..IKMLKQKRLDQLEALESKVDYYEKLCDELEEFQDEMEVKAKLEQNRRSR................
A0A120K1R2_9SACH/1-108             ............m---KEKQLRRHLDKCVDDMQIHVDLMSARAISKFTADTNANYEWLNQIKQRHS.TRHKEELRN..YFLLKAEYEKKVEVLDSKVTYLEQLAEELCEFQNELAVKVQ--------rvkraak.........
G8JS86_ERECY/1-107                 ............m---KEKILRHHLDKCVDYTQEHVDLESARAISSFGVDTNANYEWLYELNSRYP.TRKIEEIRT..YQLLKTDYMKKLDNLDGRITYFENLAKELDEFQNEVNIKMQ--------rikrst..........
G8ZQ95_TORDC/1-111                 .............MREHERVLHQDIERCVEILQESVDAEAAKAISVFSKKTSDNEEWLKDLKTKFK.LKDKVELEQ..LLSLKNKQLDQIEGIEKKIDYYERLCDELEEFQDEIEVKMKLEQSRRSR................
J8TYM2_SACK1/1-110                 ...........mg---EQNNLCYDVEKLVNSLQEAFDLDCAQGVSLFTSKSRSNEAWLEELERRFK.LKDDVELDE..VENLKTEINIKLGILEDKVSYFERLCKEFEEFQNEMKIKTVVNNRRQS-q...............
A0A1G4MKZ9_LACFM/1-108             ............m---KEKVLKQEIERCAEHVQEIVDLESAKAISEFQSKADENYQWLEELKTRYS.MRNDNE-ND..IRQLRSRHKEKIDALEEDVNYFEKLLDEMEEFVTELDVKRKLANKRQSR................
H2B003_KAZAF/1-107                 ............m------KLNQDINNYINELQTYIDTESVKTISLFNKKSQETEEWLNRLSSEFEnLKDEEELTK..LKELHESYEQNLDELESKIEYLEKLCDEIDEVYDELGVKTKVNDRRKSR................
BLI1_KLULA/1-103                   ..........mrg-----KALKSKLEELVDGIQQRIDFVTATGVSSFEQETEQNYGKLEYLQSK--.IKKDDGISD..WVDEKQRLSGRLNKLEKQVQELEELADEWENYLQLL-------------adtklrkdn.......
BLI1_LACTC/6-113                   ...........gm---KERVLRQHIEGCIDQVQEYVDLESAQAISSFESKAVDHFRCLDGLKAQYN.TRE-DKISE..FKRLQSEYATKVDGLEKSIEHFEKLSEEIEEFLVELEVKTKLASKRQS-................
A0A1X7QWE1_9SACH/8-115             ............e-RANRRQLQRDIETCVHVLQEGVDTEAAEAISVFSNKTTSNEKWATTLAGTYQ.IKTDEEFKS..FETDKRLYIEKIDKLEEEVEYFEKLCIEMEEFSKELEVKTKVERSR---................
G8BXX4_TETPH/1-111                 .............MKGEDRVVYQSIEGLVDKTQEFIDTELAKAISFFSSKSEDNKKWLNEISSTYK.LENEGTMKD..FEELKKAHIKKVDELEQKVVYFEDLYKEINELVEELAVKTKIQKKRQSR................
J7RFQ3_KAZNA/91-165                hvqradrvqrvva---------------------------------------------REITSSVQ.LKDSAELER..VQMLKEQYSQRIGELELQLDSMERLCGEMEEFLEELNLKRQ--------qrkp............
BLI1_YEAST/1-110                   ...........mg---EQNKLYYDVEKLVNSLQESFDLDCAQSVSLFTSKSRSNEAWLEELENKFK.LKDDVELDD..VENLRAEIDMKLNMLEDKVSYYERLYKELEEFQNEIKIKTVVNNRRQSR................
I2H839_TETBL/1-108                 .............MGDKYRSMNQDIDLLIQAIQDKVNVDSAKSMSTFEEKSSKKVQMLKDLTNKYN.LLNQAKLNN..ISEIKTIQLKQLDEIENKLTYLEKLCDEFDEFQNELAIKKS--------tksss...........
W0T9V8_KLUMD/1-101                 ............m---KEKALRTKIDELVATLQQRIDIVTATAVSQFEQETENNYAKLDYLKAHFK.--KDDSIND..WLNDKQEFTEKLDKLESQITELSDLADEWEIFIKELL------------ltdakl..........
BLI1_CANGA/1-103                   ............m-------IKQDVQKCVDALQDFVDKEIGESVNLFSCKSRANNELLLNIDEKFQ.LKDKDELHQ..LGEQKIENQNKLQEIRNKVEYYEKLLTELEEAQKELEVRYKLVS-----ksk.............
A0A1G4JFU8_9SACH/1-108             ............m---KERILRQHVESCTDQLQGIVDFQSAQAISAFQTKTEDNFRCLDELKDKYR.TND-ETINE..FRDLKADFNDQISKLEESIDYYENLAEEILEFLAENDVKKKLALKRQT-h...............
#=GC seq_cons                      ............h...p-+tLppclEpClsplQ-hlDh-oAcAIShFssKopsNhpWLc-Lps+ap.l+cpcElcs..hcpLKpcahcKL-pLEpclcYaE+Ls-El-EF.sElpVKpclt.pR.o.................
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