GenomeNet

Database: Pfam
Entry: Baculo_LEF-2
LinkDB: Baculo_LEF-2
Original site: Baculo_LEF-2 
#=GF ID   Baculo_LEF-2
#=GF AC   PF03041.16
#=GF DE   lef-2
#=GF PI   lef-2; 
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_1773 (release 6.4)
#=GF GA   25.00 25.00;
#=GF TC   26.10 28.80;
#=GF NC   19.00 18.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0242
#=GF RN   [1]
#=GF RM   8445724
#=GF RT   Three baculovirus genes involved in late and very late gene
#=GF RT   expression: ie-1, ie-n, and lef-2. 
#=GF RA   Passarelli AL, Miller LK; 
#=GF RL   J Virol 1993;67:2149-2158.
#=GF RN   [2]
#=GF RM   7571435
#=GF RT   Replication of Orgyia pseudotsugata baculovirus DNA: lef-2 and
#=GF RT   ie-1 are essential and ie-2, p34, and Op-iap are stimulatory
#=GF RT   genes. 
#=GF RA   Ahrens CH, Rohrmann GF; 
#=GF RL   Virology 1995;212:650-662.
#=GF RN   [3]
#=GF RM   11836407
#=GF RT   Baculovirus replication factor LEF-1 is a DNA primase. 
#=GF RA   Mikhailov VS, Rohrmann GF; 
#=GF RL   J Virol 2002;76:2287-2297.
#=GF DR   INTERPRO; IPR004283;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   The lef-2 gene (for late expression factor 2) from baculovirus
#=GF CC   is required for expression of late genes. This gene has been
#=GF CC   shown to be specifically required for expression from the vp39
#=GF CC   and polh promoters [1].  LEF-1 is a DNA primase and there is
#=GF CC   some evidence to suggest that LEF-2 may bind to both DNA and
#=GF CC   LEF-1 [3].
#=GF SQ   18
#=GS Q8JMD9_9ABAC/9-176      AC Q8JMD9.1
#=GS Q0ZP23_9CBAC/34-161     AC Q0ZP23.1
#=GS B5X0B8_9ABAC/22-189     AC B5X0B8.1
#=GS A0A097DAI1_9BBAC/2-165  AC A0A097DAI1.1
#=GS Q9QPA0_9ABAC/6-169      AC Q9QPA0.1
#=GS Q7T5Q1_GVCL/5-163       AC Q7T5Q1.1
#=GS LEF2_NPVAC/7-171        AC P41418.1
#=GS Q80LJ6_NPVAH/7-173      AC Q80LJ6.1
#=GS A0A068LKM7_9ABAC/6-169  AC A0A068LKM7.1
#=GS Q773J1_NPVR1/7-171      AC Q773J1.1
#=GS A0A109WXD9_9BBAC/3-77   AC A0A109WXD9.1
#=GS F4ZKQ6_9BBAC/4-169      AC F4ZKQ6.1
#=GS Q9QAB3_9CBAC/41-166     AC Q9QAB3.1
#=GS Q91F12_GVCPM/6-164      AC Q91F12.1
#=GS Q5Y4P5_NPVAP/47-208     AC Q5Y4P5.1
#=GS Q6JPB4_NPVNC/28-161     AC Q6JPB4.1
#=GS B7SVP1_9ABAC/6-171      AC B7SVP1.1
#=GS Q0GYL7_9ABAC/7-171      AC Q0GYL7.1
Q8JMD9_9ABAC/9-176                 ..............................swtprni-------NIDTIDKTSDYTVSL......ADI--D.INVTALTPFVDNGL.RVRVSGLRLYYLMKN....KPDIAD......TagatpkrKNaaATLK......Q....KSMK..NVC.FKG--FERD.KIVKVLNQKL.R.MPE..CMVRFMNDFLL--R.PRGDRFRKRFIFNSYVANVLTCTKC.QKQ.CIADAMATLYDHDSKCVQE---fnk............
Q0ZP23_9CBAC/34-161                ........kltplhimdqtrmfvyvdkirqlpafvsk----------------------......------.--------------.---------------....------......V.......SP..EKVE......N....TDQW..TEC.FDQQQGPPL.EIIQKTFKLL.-.-PP..CVSDALNMIDER--.PTSERFHRRFILHTYLKHKYSCKIH.QNKsCLQNLLSKLYQFDKKCVLQM--nk.............
B5X0B8_9ABAC/22-189                ...................................ll--WNPSICKSKIDKKAVYLVRF......EDF--E.LNLSPYTQFEQNGL.LVRVYGTQLYHLLDNktnnATTVYD......R.......KP..AIAKn...gmH....KSLR..NVC.FVNTQYKRQ.HIINTLRKAL.K.LPA..CIELILNDILV--R.PRNGRFRKRFVFNCYISNLLTCTKC.NKQ.CIERAMIALYQNDEKCVRE---fqs............
A0A097DAI1_9BBAC/2-165             ....................................e-TFHPRI---PIDATKTYKV--......DKFLMKfQSIGGEHTFLPGGR.YFVMLGKQLKLLVEQ....SMSFED......D.......ET..TECA......I....SNKK..RMCvFCSVLNSRD.TIIAHYKRVLfN.YHS..KPTKSLEAFNNLCIkVRNKRYNNRLTFNYFVVKRLQCIQC.QNK.CVYEALRKFYNMESKCVNQV--dr.............
Q9QPA0_9ABAC/6-169                 .............................swtpsnid----------DIDKNAEYSV--......-LFSDIpLQVTCLTPFIDKGL.RVKINGHRLYYLIKN....KDQYAE......Al....tpKN..NKWS......LnniyKSHK..NVC.FQNVSS-IN.NVVDILKTKL.N.MPD..CMQRFLADFQV--R.PRGKRFRKRFIFNAYIANVITCTKC.NKL.CLVKAMSYIYGFDEKCVQE---fd.............
Q7T5Q1_GVCL/5-163                  ......................tvfhprlpvesdkiy--------------------KV......DIFLMRwANINLNTSFLPGGR.FFLVSGICLKNLINK....SKSFEE......-.......-H..KEMV......Y....DVKK.tNVC.FLTY-TNRE.DIIKIYRKIF.Y.SKS..NAKTEESFKKLCIR.PRTNRYACRLSFNYLVVKRLQCCEC.NNI.CVYDALKLFYLMDSKCVKQV--dn.............
LEF2_NPVAC/7-171                   .....................................NVWSPLIRASCLDKKATYLIDP......DDFIDK.LTLTPYTVFYNGGV.LVKISGLRLYMLLTA....PPTINE......I.......KN..SNFK......K....RSKR..NIC.MKECVEGKK.NVVDMLNNKI.N.MPP..CIKKILNDLKENNV.PRGGMYRKRFILNCYIANVVSCAKC.ENR.CLIKALTHFYNHDSKCVGEVMH...............
Q80LJ6_NPVAH/7-173                 ....................................l-AWNPSIKPSEINKSALYTVSL......EDF-ED.VEVSPYTVFFPPGSmTIKMSGARLYYMLNK....KAEQNH......-.......KK..TLLNpnkkplR....KSLK..NVC.FKSSV-RKQ.QVSDLLSASI.K.MPK..CMLTIFNLLQAN--.PRGGQYYNRFVFNCYIGNVFTCTRC.DKK.CIADALLIFYMNDDKCVREV--nt.............
A0A068LKM7_9ABAC/6-169             ...................................ls--WTPSSCASDIDKDADYAVVP......GEL--P.IDLTPFTPFLDNGL.RLRVSGVRLYYLLKN....RDKFDA......A.......TA..TAEQqr.rpfK....KSLK..NVC.LRQV-QNKQ.GAAKALTAAL.R.MPD..CIARLLAAIEI--Q.PRGNRYRKRFIFNAYVANVLTCTKC.NKR.CIVDAMALLYEHEEKCTL----efd............
Q773J1_NPVR1/7-171                 .....................................NVWSPLISASCLDKKATYLIDP......DDFIDK.LTLTPYTVFYNGGG.LIKISGLRLYMLLTA....PPTINE......I.......KN..SNFK......K....RSKR..NIC.MKECAEGKK.NVVDMLNSKI.N.MPP..CIKKILGDLKENNV.PRGGMYRKRFILNCYIANVVSCAKC.ENR.CLINALTHFYNHDSKCVGEVMH...............
A0A109WXD9_9BBAC/3-77              ...............................iyremm------------------PIDPnttykvDSFIKR.WQINAHMAFLPGGR.YFMVTGNTLIKMKES....AIEFDE......Y.......AA..----......-....----..---.---------.----------.-.---..--------------.-------------------------.---.----------------------ataaaaaasqnhplq
F4ZKQ6_9BBAC/4-169                 .....................................EVYHP---RRPVDRTKTYKV--......DVFMRRwVTVGPDVTFIQGGR.YFVLSGKNLDVLVKK....SPTFDEe...vsV.......YG..TSSS......T....SNKR..DVC.FLGCLGDRQ.ALIDKYNKLF.Y.SRTtgGLKSETAFKKLCVR.PRRNRYANRLTFNYLIVKRLKCDAC.SNV.CVYDALKMFYNMDDKCVAQV--dd.............
Q9QAB3_9CBAC/41-166                ..................tldktrlyvfvknvndpnl----------------------......------.--------------.--------------K....PKNVND......I.......KS..PSKN......H....SYKRqrYPC.FNTISGS--.-TIHKICNVM.K.PPP..CVRHALKLIDE--R.PMKHRFQQRFVVQTYMSRKYLCESCtDNE.CLNQILSELYHNEKKCMTQLK-h..............
Q91F12_GVCPM/6-164                 ....................................e-TYHP--------RRA---IDPtklykvDMFLRHwVNVNGNTAFLPGGR.YFLVVGRCLLNLVEK....SKSFEE......-.......-H..TKVE......E....NAKK.vKVC.FEDCGGNRE.AIIAKFRKLF.Y.SRP..NAKTEPSFNKLCVR.PRRQRYACRLSFNFLVVKRLQCCRC.DNK.CVYDALKRFYKMDSKCVSQV--d..............
Q5Y4P5_NPVAP/47-208                ....................................r-AWNPAAGAASLRKNESYLIDP......ADFVGV.LTLSPTTVFEPG-L.LVRMSGLRLLSLLSA....PKPVAA......-.......-K..RPLP......V....RSRR..NVC.LKACADGSQ.SLPKVLAARI.N.MPL..CMAKIMAELSGAVS.PRGGMYCKRFAFNCYLGNVVTCTKC.KSA.CLIGALLHFYRMDPKCVGEVTH...............
Q6JPB4_NPVNC/28-161                ytlfpdkltplhimdptrmfvyvdkirqlpipvskvl----------------------......------.--------------.---------------....------......-.......--..---P......E....KIEK..TIQ.WMDCCDQQQgTPLEIIRRNF.KfLPP..CISKALDMIDERTT.--SERFHRRFIFHTYLIHKYSCKIH.KNKsCLQNLLSKLYESNKKCVLQM--hk.............
B7SVP1_9ABAC/6-171                 ...........................swtpsniddv---------ESIDKNADYSVSL......---CDMpLQVTCLTPFLDNGL.RVKINGHRLYYLIKN....REALVEaeakksI.......MT..TTTK......Y....KSHK..NVC.FQN-ASSKD.TVIEMLKTKL.N.LPD..CMQRFLLDFQV--R.PRGKRFRKRFIFNAYIANVLTCTKC.NKL.CLVKAMSYIYNFDDKCIQE---fd.............
Q0GYL7_9ABAC/7-171                 .....................................NVWSPLIRASCLDKKATYLIDP......DDFIDK.LTLTPYTVFYNGGV.LVKISGLRLYMLLTA....PPTINE......I.......KN..SNFK......K....RSKR..NIC.MKECVEGKK.NVVDMLNNKI.N.MPP..CIKKILGDLKENNV.PRGGMYRKRFILNCYIANVVSCAKC.ENR.CLIKALTHFYNHDSKCVGEVMH...............
#=GC seq_cons                      ................................................lc+pt.Y.lp.......s.F..c.lslsshTsFhssGh.hhhlsGhpLhhLlpp....s.shs-......h.......ps..sphp......p....+u++..NlC.Fpss.ts+p.sllchlpptl.p.hPs..Chp+hLs.hp...p.PRupRap+RFlFNsYluphloCs+C.psp.ClhcALpthYphDsKCVtph...p.............
//
DBGET integrated database retrieval system