GenomeNet

Database: Pfam
Entry: Birna_VP2
LinkDB: Birna_VP2
Original site: Birna_VP2 
#=GF ID   Birna_VP2
#=GF AC   PF01766.18
#=GF DE   Birnavirus VP2 protein
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_946 (release 4.2)
#=GF GA   19.70 19.70;
#=GF TC   21.40 355.20;
#=GF NC   19.10 18.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Birnaviridae
#=GF RN   [1]
#=GF RM   2828658
#=GF RT   Birnavirus precursor polyprotein is processed in Escherichia
#=GF RT   coli by its own virus-encoded polypeptide. 
#=GF RA   Jagadish MN, Staton VJ, Hudson PJ, Azad AA; 
#=GF RL   J Virol 1988;62:1084-1087.
#=GF RN   [2]
#=GF RM   8525637
#=GF RT   Strain variability and localization of important epitopes on the
#=GF RT   major structural protein (VP2) of infectious pancreatic necrosis
#=GF RT   virus. 
#=GF RA   Heppell J, Tarrab E, Lecomte J, Berthiaume L, Arella M; 
#=GF RL   Virology 1995;214:40-49.
#=GF DR   INTERPRO; IPR002662;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   VP2 is the major structural protein of birnaviruses [2]. The
#=GF CC   large RNA segment of birnaviruses codes for a polyprotein
#=GF CC   (N-VP2-VP4-VP3-C) [1].
#=GF SQ   10
#=GS A0A1B2FQQ0_IBDV/9-452  AC A0A1B2FQQ0.1
#=GS POLS_IPNVS/5-453       AC Q703G9.1
#=GS POLS_IPNVS/5-453       DR PDB; 3IDE C; 6-428;
#=GS POLS_IPNVS/5-453       DR PDB; 3IDE B; 6-428;
#=GS POLS_IPNVS/5-453       DR PDB; 3IDE A; 6-428;
#=GS POLS_IPNVS/5-453       DR PDB; 3IDE E; 6-428;
#=GS POLS_IPNVS/5-453       DR PDB; 3IDE D; 6-428;
#=GS POLS_BSNV/7-428        AC Q8AZM0.1
#=GS D0U495_9VIRU/1-431     AC D0U495.1
#=GS POLS_IPNVJ/5-453       AC P05844.2
#=GS POLS_DXV96/2-442       AC Q96724.1
#=GS Q2PBR5_9VIRU/11-462    AC Q2PBR5.1
#=GS G9I7F9_9VIRU/2-442     AC G9I7F9.1
#=GS POLS_IBDVU/9-452       AC Q82635.1
#=GS Q9WLE3_9VIRU/5-453     AC Q9WLE3.1
A0A1B2FQQ0_IBDV/9-452             ...QQIVPFIRSLLMPTTGPASIPDDTLEKHTLRSETSTYNLTVGDTGSGLIVFFPGFPGSIVGAHYTLQ-SNGNYKFDQMLLTAQNLPASYNYCRLVSRSLTVRSSTLPGGVYALNGTINAVTFQGSLSELT.DVSYNGLMSATANINDKIGNVLVGEGVTVLSLPTSYDLGYVRLGDPIPAIGLDPKMV-ATCDSSDRPRVYTITaan...dyqfSSQYQAGGVTITLFSANIDAITSLSI..GGELVFQ....TSVQGLILGATIYLIGFDG....TAVITRA-VAADN--GLTAGTDNLM.PFNV---.VIPTSAITQPITSIKLEIVT-SKSGGQAgdqmSWSAS.GSLAVTIHGGNYPGALRPVTLVAYERVATGSVVTVAGVSNFELIPNPELAKNLVTEYGRFDPGAMNYTKLILSERDRLGIKTVWPTREYTDFREYFMEVADLNSPLKI..AGAFGFKDIIRAIR.
POLS_IPNVS/5-453                  ...KATATYLKSIMLPETGPASIPDDITERHILKQETSSYNLEVSESGSGVLVCFPGAPGSRIGAHYRWNANQTGLEFDQWLETSQDLKKAFNYGRLISRKYDIQSSTLPAGLYALNGTLNAATFEGSLSEVE.SLTYNSLMSLTTNPQDKVNNQLVTKGVTVLNLPTGFDKPYVRLEDETPQGLQSMNGAKMRCTAAIAPRRYEIDlp.....sqrLPPVPATGTLTTLYEGNADIVNSTTV..TGDINFSl.aeQPADETKFDFQLDFMGLDNdvpvVTVVSSVLATNDNYRGVSA------.----KMTqSIPTENITKPITRVKLSYKINQQTAIGNvatlGTMGP.ASVSFSSGNGNVPGVLRPITLVAYEKMTPLSILTVAGVSNYELIPNPELLKNMVTRYGKYDPEGLNYAKMILSHREELDIRTVWRTEEYKERTRVFNEITDFSSDLPT..SKAWGWRDIVRGIR.
#=GR POLS_IPNVS/5-453       SS    ...X--THHHHHHH-GGG------SS----BEEEEEEEEEEEE--TT--EEEEE-TT-SSSEEEEEEEE-TTSSSEEEEEEEE-SS-GGGTEEEEEEEEEEEEEEE------------EEEEEEESS-GGG-S.---TTGGGGS---GGGEEEEEETTT-EEEE---S-SS---EE--EE----TTS-TT---EE---SS-EEEEEEE-.....SSB----SSTT--EEEEEEEEEE-S-EEE..EEEEEEEE.SS--SS-EEEEEEEEEE-SSTT--SEEEEEEEEE-TTTTTSEEE------.----EE--EE-GGG--S-EEEEEEEEE-S-GGGTTS-EESGGGS-.EEEEEEETTTTSTTTSS-EEEEEEES--TT-EEEEEEEEEEEEEE-HHHHTT---B-----TTHHHHHHHHHHTTTTTT--SEEEHHHHHHTTGGG-XXXXXXXXXXX..XXXXXXXXXXXXXX.
POLS_BSNV/7-428                   ...NTQIRYLNSLLVPETGSTSIPDDTLDRHCLKTETTTENLVAALGGSGLIVLFPNSPSGLLGAHYTKT-PQGSLIFDKAITTSQDLKKAYNYARLVSRIVQVRSSTLPAGVYALNGTFNGVTYIGSLSEIK.DLDYNSLLSATANINDKVGNVLVGDGVAVLSLPAGSDLPYVRLGDEVPSSAGV-----ARCSPSDRPRHYNAN..........NKQVQVGTTDTKTNGFNIDATTPTEV..TVDMQIA....QIAAGKTLTVTVKLMGLTG....AKVASRSETVSGN--GGT-------.-FHFSTTaVFGETEITQPVVGVQVL----AKTNGD-....PIVVD.SYVGVTVHGGNMPGTLRPVTIIAYESVATGSVLTLSGISNYELIPNPELAKNIQTSYGKLNPAEMTYTKVVLSHRDELGLRSIWSIPQYRDMMSYFREVSDRSSPLKI..AGAFGWGDLLSGIR.
D0U495_9VIRU/1-431                .ms---NEYLRSILMPERGPSSIPDDNVRRHCVRQETITANIVVGSSGKGAFVLFPNNPSSLIGAHFKYDDQGKSYKYTQSLVVAQRLNESYNYGRKSAGVIYIRSSTLPSGVYNISGTINAATYEGPPSEVG.LPEYNKILSITSNPMDKLGNVGVLEGVAVLTLPASYDIDYTRLADLSPSSAKNGCVVNDSGQSLIYTQYDEIN..........Y----TGSQEKQLLSFNIDSNILVTT..TATLDFY....TTASDAQVTIKIKYLGIDG....LVVSENEIISRIDSLERTVSIDAFY.PFPQ---.VI-KEGGQEPVAAVELYLTSDKSTSITG....TI---.-RSITTAHSAARPGITSPTTIVAYEGVQSGASITVAGVSNYELIPNPELARNMETRYARTDPYGMIYTKYVLANRDRLGIRSVWPTNDYKARFPLFEELGLMQSDASIteAMAFGIHDVISWIR.
POLS_IPNVJ/5-453                  ...KATATYLRSIMLPENGPASIPDDITERHILKQETSSYNLEVSESGSGLLVCFPGAPGSRVGAHYRWNLNQTALEFDQWLETSQDLKKAFNYGRLISRKYDIQSSTLPAGLYALNGTLNAATFEGSLSEVE.SLTYNSLMSLTTNPQDKVNNQLVTKGITVLNLPTGFDKPYVRLEDETPQGPQSMNGARMRCTAAIAPRRYEIDlp.....serLPTVAATGTPTTIYEGNADIVNSTAV..TGDITFQl.eaEPVNETRFDFILQFLGLDNdvpvVTVTSSTLVTADNYRGASA------.----KFTqSIPTEMITKPITRVKLAYQLNQQTAIANaatlGAKGP.ASVSFSSGNGNVPGVLRPITLVAYEKMTPQSILTVAGVSNYELIPNPDLLKNMVTKYGKYDPEGLNYAKMILSHREELDIRTVWRTEEYKERTRAFKEITDFTSDLPT..SKAWGWRDLVRGIR.
POLS_DXV96/2-442                  ...NTTNEYLKTLLNPAQFISDIPDDIMIRHVNSAQTITYNLKSGASGTGLIVVYPNTPSSISGFHYIWDSATSNWVFDQYIYTAQELKDSYDYGRLISGSLSIKSSTLPAGVYALNGTFNAVWFQGTLSEVS.DYSYDRILSITSNPLDKVGNVLVGDGIEVLSLPQGFNNPYVRLGDKSPSTLSSPTHITNTSQNLATGGAYMIP..........VTTVPGQGFHNKEFSINVDSVGPVDIlwSGQMTMQ....---DEWTVTANYQPLNISG....TLIANSQRTLTWSNTGVSNGSHYMN.MNNLNVS.LFHENPPPEPVAAIKININYGNNTNGDS....SFSVD.SSFTINVIGGATIGVNSPTVGVGYQGVAEGTAITISGINNYELVPNPDLQKNLPMTYGTCDPHDLTYIKYILSNREQLGLRSVMTLADYNRMKMYMHVLTNYHVDERE..ASSFDFWQLLKQIK.
Q2PBR5_9VIRU/11-462               trk---SPYIKSLLLPETGPASIPDDKIRRHVKRSESTTTNLTS-TTGKGMLIVYNNHPKNLVGSHYTYA-SDGKLRFDRNLYTAQDLSKNFNYGRKVSQLVTIKSTQLPAGVYAMQGTMNGVCIDGAPSEVEtALKYETILSASTNALDKVAGVLVNDGVGVLSLPTTFDNDYIRMGDPAPSSFTP--GSAQLSKPTHNPGLNSIVtagttgltsgTKTISTTKTIISTDVINVDSTEGLLL..DLNIQLMrwgvPSGKTATVTVDVKTVDLAG....AETDAEQREIKIS--GTNTGRDNVItLSGLMMG.LSGKKPLVAPTAAVVIEVSAISSESMTL....THSGHiNNYSLTSLCAGTPGTTNPITIIIYTDLTPGGIMTVTAVSNFELIPNAELRKNIPTDFGNSDPSEMDFIKRILGQRETLELRTIWDMGMYDARRDVLSEFAHLD-DNSL..AMAWEWSDVLWWI-k
G9I7F9_9VIRU/2-442                ...NTSNEYLKTLLDPAQFIADIPDDIMIRHINRAETITYNLKTGASGTGLIVFYPNTPSSVAGFHYRWDAENSVWAFDQYIYTAQELKKSYDYGRLISGAVSVKSSSIPSGVYALTGTFNAVWFQGTLSEVS.NLNYDRILSITSNPLDKVGNVLVGDGLAVLSLPQGFNNPYVRLGDESPSSLTSVTHITNTSQNLGYGGAFAVP..........QTTVAGQGTFFKEFNINVDSVGPIDVtwSGLMTMQ....---DEWTVTANYQPLNLSG....TLIQGSMRTIIWSNVGVSNGTHYMN.LNEINVS.FFHENPPPEPVAAIKVHITFGNNTNGES....SMNVD.GSFTFHVVGGATIGVNSPTVMIGYQGVASGSTITLSGVNNYELVPNPALQKNLPMSYGTCDPTDLNYVKYILSNREKLGIRSVMTLAQYAKMKMQMNIMTDYHVGDRE..ASSFDFWHLLKQIK.
POLS_IBDVU/9-452                  ...QQIVPFIRSLLMPTTGPASIPDDTLEKHTLRSETSTYNLTVGDTGSGLIVFFPGFPGSIVGAHYTLQ-SNGNYKFDQMLLTAQNLPASYNYCRLVSRSLTVRSSTLPGGVYALNGTINAVTFQGSLSELT.DVSYNGLMSATANINDKIGNVLVGEGVTVLSLPTSYDLGYVRLGDPIPAIGLDPKMV-ATCDSSDRPRVYTITaad...dyqfSSQYQAGGVTITLFSANIDAITSLSI..GGELVFQ....TSVQGLILGATIYLIGFDG....TAVITRA-VAADN--GLTAGTDNLM.PFNI---.VIPTSEITQPITSIKLEIVT-SKSGGQAgdqmSWSAS.GSLAVTIHGGNYPGALRPVTLVAYERVATGSVVTVAGVSNFELIPNPELAKNLVTEYGRFDPGAMNYTKLILSERDRLGIKTVWPTREYTDFREYFMEVADLNSPLKI..AGAFGFKDIIRALR.
Q9WLE3_9VIRU/5-453                ...KATATYLRSIMLPENGPASIPDDITERHILKQETSSYNLEVSDSGSGLLVCFPGAPGSRVGAHYRWNLNQTELEFDQWLETSQDLKKAFNYGRLISRKYDIQSSTLPAGLYALNGTLNAATFEGSLSEVE.SLTYNSLMSLTTNPQDKVNNQLVTKGITVLNLPTGFDKPYVRLEDETPQGPQSMNGARMRCTAAIAPRRYEIDlp.....serLPTVAATGTPTTIYEGNADIVNSTTV..TGDVTFQl.aaEPVNETRFDFILQFLGLDNdvpvVSVTSSTLVTADNYRGASA------.----KFTqSIPTELITKPITRVKLAYQLNQQTAIGNaatlGAKGP.PSVSFSSGNGNVPGVLRPITLVAYEKMTPQSILTVAGVSNYELIPNPDLLKNMVTKYGKYDPEGLNYAKMILSHREELDIRTVWRTEEYKERTRAFNEITDFTSDLPT..SKAWGWRDLVRGIR.
#=GC SS_cons                      ...X--THHHHHHH-GGG------SS----BEEEEEEEEEEEE--TT--EEEEE-TT-SSSEEEEEEEE-TTSSSEEEEEEEE-SS-GGGTEEEEEEEEEEEEEEE------------EEEEEEESS-GGG-S.---TTGGGGS---GGGEEEEEETTT-EEEE---S-SS---EE--EE----TTS-TT---EE---SS-EEEEEEE-.....SSB----SSTT--EEEEEEEEEE-S-EEE..EEEEEEEE.SS--SS-EEEEEEEEEE-SSTT--SEEEEEEEEE-TTTTTSEEE------.----EE--EE-GGG--S-EEEEEEEEE-S-GGGTTS-EESGGGS-.EEEEEEETTTTSTTTSS-EEEEEEES--TT-EEEEEEEEEEEEEE-HHHHTT---B-----TTHHHHHHHHHHTTTTTT--SEEEHHHHHHTTGGG-XXXXXXXXXXX..XXXXXXXXXXXXXX.
#=GC seq_cons                     ...pspssYL+SLLhPEsGPASIPDDhh-RHlL+sEToTYNLpVusSGSGLlVhFPssPuSllGAHYpas.ssushcFDQhLhTAQ-LKKuYNYGRLlSRplsI+SSTLPAGVYALNGTlNAVTFpGSLSEVp.sLoYNuLhSlToNPpDKVGNVLVs-GVsVLSLPTGFDpPYVRLGDcoPuusps.stspspCsuuttPRtYpIshs......phhssVsusGThpolashNlDulsulsl..oG-lsFQ....psss-tplssslphlGLDG....ssVsosshssssN.hGsosu.c.h....thpho.lIsppsITcPlsuVKLplshsspTuhss....ohsus.uSlohostuGNsPGlLRPlTlVAYEcVssGSllTVAGVSNYELIPNPELtKNlsTcYG+hDPpuhNYsKhILScREcLGIRTVWsTp-Yc-hpchFpEloDhsSDLph..AtAFGa+Dll+uIR.
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