#=GF ID CAF1A
#=GF AC PF12253.12
#=GF DE Chromatin assembly factor 1 subunit A
#=GF PI CAF1B;
#=GF AU Wood V;0000-0001-6330-7526
#=GF AU Coggill P;0000-0001-5731-1588
#=GF SE manual
#=GF GA 25.00 25.00;
#=GF TC 25.20 25.50;
#=GF NC 24.70 24.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 17065558
#=GF RT Essential role of chromatin assembly factor-1-mediated rapid
#=GF RT nucleosome assembly for DNA replication and cell division in
#=GF RT vertebrate cells.
#=GF RA Takami Y, Ono T, Fukagawa T, Shibahara K, Nakayama T;
#=GF RL Mol Biol Cell. 2007;18:129-141.
#=GF RN [2]
#=GF RM 19172751
#=GF RT The HP1-p150/CAF-1 interaction is required for pericentric
#=GF RT heterochromatin replication and S-phase progression in mouse
#=GF RT cells.
#=GF RA Quivy JP, Gerard A, Cook AJ, Roche D, Almouzni G;
#=GF RL Nat Struct Mol Biol. 2008;15:972-979.
#=GF DR INTERPRO; IPR022043;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC The CAF-1 or chromatin assembly factor-1 consists of three
#=GF CC subunits, and this is the first, or A [1]. The A domain is
#=GF CC uniquely required for the progression of S phase in mouse cells
#=GF CC [2], independent of its ability to promote histone deposition
#=GF CC [1] but dependent on its ability to interact with HP1 -
#=GF CC heterochromatin protein 1-rich heterochromatin domains next to
#=GF CC centromeres that are crucial for chromosome segregation during
#=GF CC mitosis. This HP1-CAF-1 interaction module functions as a
#=GF CC built-in replication control for heterochromatin, which, like a
#=GF CC control barrier, has an impact on S-phase progression in
#=GF CC addition to DNA-based checkpoints [2].
#=GF SQ 2293
#=GS A4HUH0_LEIIN/349-444 AC A4HUH0.1
#=GS A0A6P5MW55_ARADU/172-242 AC A0A6P5MW55.1
#=GS A0A2T9Y975_9FUNG/436-517 AC A0A2T9Y975.1
#=GS A0A1E3HMN2_9TREE/467-544 AC A0A1E3HMN2.1
#=GS A0A850VGT1_FREMA/533-606 AC A0A850VGT1.1
#=GS A0A5N7ABZ6_9EURO/414-490 AC A0A5N7ABZ6.1
#=GS A0A7R7VUA4_ASPCH/393-469 AC A0A7R7VUA4.1
#=GS A0A3Q7NA44_CALUR/643-717 AC A0A3Q7NA44.1
#=GS A0A814EQE5_ADIRI/280-358 AC A0A814EQE5.1
#=GS A0A061HH71_BLUGR/309-384 AC A0A061HH71.1
#=GS B8PDJ5_POSPM/237-310 AC B8PDJ5.1
#=GS S7QFV4_GLOTA/478-552 AC S7QFV4.1
#=GS A0A643CAD9_BALPH/393-449 AC A0A643CAD9.1
#=GS A0A8C9HMI6_9PRIM/539-613 AC A0A8C9HMI6.1
#=GS A0A7M5X545_9CNID/432-505 AC A0A7M5X545.1
#=GS A0A1S3T5P8_SALSA/517-593 AC A0A1S3T5P8.1
#=GS A0A8H7BFM2_9PLEO/321-397 AC A0A8H7BFM2.1
#=GS A0A7J7F5I7_DICBM/608-682 AC A0A7J7F5I7.1
#=GS A0A2P4ZIG8_9HYPO/392-470 AC A0A2P4ZIG8.1
#=GS G9MHF1_HYPVG/324-402 AC G9MHF1.1
#=GS E3S621_PYRTT/329-405 AC E3S621.1
#=GS A0A6G0UPY9_9BILA/1029-1103 AC A0A6G0UPY9.1
#=GS A0A7K7SEA7_9PASS/521-594 AC A0A7K7SEA7.1
#=GS K5X560_AGABU/444-518 AC K5X560.1
#=GS A0A444ZR59_ARAHY/503-578 AC A0A444ZR59.1
#=GS R7SE92_TREMS/379-456 AC R7SE92.1
#=GS A0A7K6IAM7_9PASS/532-605 AC A0A7K6IAM7.1
#=GS A0A093P670_PYGAD/533-606 AC A0A093P670.1
#=GS A0A139WAU3_TRICA/353-425 AC A0A139WAU3.1
#=GS B6K6E2_SCHJY/311-386 AC B6K6E2.1
#=GS A0A851LWY1_CORCR/534-607 AC A0A851LWY1.1
#=GS A0A1M2VMP7_TRAPU/500-575 AC A0A1M2VMP7.1
#=GS A0A2X0M5X9_9BASI/685-760 AC A0A2X0M5X9.1
#=GS A0A1X6N955_9APHY/237-310 AC A0A1X6N955.1
#=GS A0A197JJH0_9FUNG/767-843 AC A0A197JJH0.1
#=GS A0A165UQN3_9AGAM/512-585 AC A0A165UQN3.1
#=GS A0A8B8X3G3_BALMU/561-635 AC A0A8B8X3G3.1
#=GS A0A8C8RY14_9SAUR/489-548 AC A0A8C8RY14.1
#=GS A0A7K9WGZ5_9PASS/518-591 AC A0A7K9WGZ5.1
#=GS A0A553P0B6_TIGCA/589-661 AC A0A553P0B6.1
#=GS Q54JS6_DICDI/287-384 AC Q54JS6.1
#=GS A0A8H5MQD6_9HYPO/358-436 AC A0A8H5MQD6.1
#=GS A0A078HPE9_BRANA/461-544 AC A0A078HPE9.1
#=GS A0A0N0VDT9_LEPPY/377-459 AC A0A0N0VDT9.1
#=GS A0A232EIC1_9HYME/577-650 AC A0A232EIC1.1
#=GS A0A5C3EQH8_9BASI/565-640 AC A0A5C3EQH8.1
#=GS U7Q0B6_SPOS1/482-558 AC U7Q0B6.1
#=GS A0A545W823_9HYPO/362-439 AC A0A545W823.1
#=GS K0KJG0_WICCF/308-379 AC K0KJG0.1
#=GS A0A3Q2ZYV0_KRYMA/358-432 AC A0A3Q2ZYV0.1
#=GS A0A6P8RX08_GEOSA/590-664 AC A0A6P8RX08.1
#=GS A0A1Y2HQJ3_9FUNG/118-177 AC A0A1Y2HQJ3.1
#=GS A0A7K5EDZ0_POLCE/527-600 AC A0A7K5EDZ0.1
#=GS A0A3P7PVC8_CYLGO/4-67 AC A0A3P7PVC8.1
#=GS A0A8B9CZ78_9AVES/533-606 AC A0A8B9CZ78.1
#=GS A0A5J9VTS7_9POAL/375-446 AC A0A5J9VTS7.1
#=GS A0A167E9S3_9ASCO/529-568 AC A0A167E9S3.1
#=GS A0A2P6R4Z5_ROSCH/484-566 AC A0A2P6R4Z5.1
#=GS A0A8J5YBS9_9ROSI/515-595 AC A0A8J5YBS9.1
#=GS A0A673J2C0_9TELE/401-475 AC A0A673J2C0.1
#=GS A0A7K9XYH6_9GRUI/528-601 AC A0A7K9XYH6.1
#=GS A0A7K4YUR1_BUCAB/534-607 AC A0A7K4YUR1.1
#=GS A0A7L4CXB8_9AVES/533-606 AC A0A7L4CXB8.1
#=GS S3D8I4_GLAL2/402-477 AC S3D8I4.1
#=GS A0A1E3P5A8_WICAA/310-379 AC A0A1E3P5A8.1
#=GS A0A662WI23_9STRA/736-811 AC A0A662WI23.1
#=GS A0A8H7GP59_9ASCO/401-481 AC A0A8H7GP59.1
#=GS A0A4U1FA69_MONMO/566-640 AC A0A4U1FA69.1
#=GS A0A1Y2WVH8_9PEZI/402-476 AC A0A1Y2WVH8.1
#=GS L8X6S8_THACA/662-734 AC L8X6S8.1
#=GS A0A6J0PMF6_ELAGV/509-590 AC A0A6J0PMF6.1
#=GS A0A2T3B9B2_AMORE/384-459 AC A0A2T3B9B2.1
#=GS A0A2I0WXE6_9ASPA/518-596 AC A0A2I0WXE6.1
#=GS A0A507C3I0_9FUNG/598-668 AC A0A507C3I0.1
#=GS A0A672PH71_SINGR/359-433 AC A0A672PH71.1
#=GS A0A8J5V1Y9_9ASCO/372-452 AC A0A8J5V1Y9.1
#=GS A0A836JWQ0_9HYME/519-562 AC A0A836JWQ0.1
#=GS A0A1B9I5R8_9TREE/497-574 AC A0A1B9I5R8.1
#=GS A0A8J6ACI8_GALPY/714-788 AC A0A8J6ACI8.1
#=GS A0A8C3V9B2_CATUS/473-546 AC A0A8C3V9B2.1
#=GS A0A7J7IHP0_9RHOD/144-220 AC A0A7J7IHP0.1
#=GS A0A162RQW9_MUCCL/313-387 AC A0A162RQW9.1
#=GS A0A3P8YI29_ESOLU/334-409 AC A0A3P8YI29.2
#=GS A0A7J7MMF1_9MAGN/494-564 AC A0A7J7MMF1.1
#=GS Q5KL37_CRYNJ/501-581 AC Q5KL37.2
#=GS A0A2V1BUC7_9HELO/398-475 AC A0A2V1BUC7.1
#=GS A0A2H3IWP9_9EURO/366-443 AC A0A2H3IWP9.1
#=GS A0A166F7G8_9AGAM/467-542 AC A0A166F7G8.1
#=GS A0A0E0LJ86_ORYPU/441-514 AC A0A0E0LJ86.1
#=GS A0A0B7F2Y6_THACB/385-456 AC A0A0B7F2Y6.1
#=GS A0A836GDU1_9HYME/491-562 AC A0A836GDU1.1
#=GS A0A7K6UA40_9AVES/531-604 AC A0A7K6UA40.1
#=GS D7KRW0_ARALL/480-561 AC D7KRW0.1
#=GS M3J8A7_CANMX/286-367 AC M3J8A7.1
#=GS W9VXT8_9EURO/332-410 AC W9VXT8.1
#=GS F7C253_HORSE/542-613 AC F7C253.3
#=GS A0A507QH81_MONPU/168-244 AC A0A507QH81.1
#=GS A0A3M7NVU4_9EURO/353-422 AC A0A3M7NVU4.1
#=GS A0A8C0G182_CHEAB/426-506 AC A0A8C0G182.1
#=GS A0A194VA96_9PEZI/620-697 AC A0A194VA96.1
#=GS A0A1V6YZ30_PENNA/394-470 AC A0A1V6YZ30.1
#=GS A0A194S5Z3_RHOGW/656-730 AC A0A194S5Z3.1
#=GS A0A7K7WJX6_9AVES/534-607 AC A0A7K7WJX6.1
#=GS J3L6P6_ORYBR/597-672 AC J3L6P6.1
#=GS A0A2I4FMG8_JUGRE/454-535 AC A0A2I4FMG8.1
#=GS E5AEN5_LEPMJ/338-414 AC E5AEN5.1
#=GS A0A165HW57_9BASI/477-552 AC A0A165HW57.1
#=GS A0A850YDM8_AEGCA/523-596 AC A0A850YDM8.1
#=GS A0A5M3N0N9_CONPW/452-526 AC A0A5M3N0N9.1
#=GS A0A7N0TBR1_KALFE/475-557 AC A0A7N0TBR1.1
#=GS A0A6P4J9V0_DROKI/656-730 AC A0A6P4J9V0.1
#=GS A0A1J8QP30_9AGAM/320-391 AC A0A1J8QP30.1
#=GS A0A5Q4BAW3_9PEZI/371-450 AC A0A5Q4BAW3.1
#=GS A0A5N6D1R0_ASPPA/360-436 AC A0A5N6D1R0.1
#=GS A0A5J5B859_9ASTE/489-570 AC A0A5J5B859.1
#=GS I1RQ05_GIBZE/355-433 AC I1RQ05.1
#=GS A0A6J0XMN8_ODOVR/545-619 AC A0A6J0XMN8.1
#=GS A0A8V1A7W0_CHICK/526-599 AC A0A8V1A7W0.1
#=GS A0A444XNV8_ARAHY/172-242 AC A0A444XNV8.1
#=GS A7TT85_VANPO/331-406 AC A7TT85.1
#=GS W9XGY4_9EURO/326-404 AC W9XGY4.1
#=GS A0A0E0LJ87_ORYPU/441-514 AC A0A0E0LJ87.1
#=GS M7TRC4_BOTF1/415-490 AC M7TRC4.1
#=GS A0A1X7U6K2_AMPQE/276-349 AC A0A1X7U6K2.1
#=GS A0A0W8D4T7_PHYNI/584-656 AC A0A0W8D4T7.1
#=GS A0A814DBY8_9BILA/282-361 AC A0A814DBY8.1
#=GS A0A815FIT0_9BILA/184-263 AC A0A815FIT0.1
#=GS A0A8A3PFX7_9HELO/400-475 AC A0A8A3PFX7.1
#=GS A0A1U7ZXG0_NELNU/490-564 AC A0A1U7ZXG0.1
#=GS A0A1R3IIX7_9ROSI/463-539 AC A0A1R3IIX7.1
#=GS A0A167BFZ5_METRR/361-438 AC A0A167BFZ5.1
#=GS Q6CSC8_KLULA/335-410 AC Q6CSC8.1
#=GS A0A8R1EJB1_CAEJA/26-100 AC A0A8R1EJB1.1
#=GS A0A4U0W5K6_9PEZI/348-424 AC A0A4U0W5K6.1
#=GS A0A2G7FKW6_9EURO/414-490 AC A0A2G7FKW6.1
#=GS A0A3Q7TD09_VULVU/561-635 AC A0A3Q7TD09.1
#=GS A0A8J6D5X2_9ROSI/475-550 AC A0A8J6D5X2.1
#=GS A0A091JRE8_EGRGA/514-587 AC A0A091JRE8.1
#=GS J7RNN1_KAZNA/346-426 AC J7RNN1.1
#=GS G0NXP3_CAEBE/309-381 AC G0NXP3.1
#=GS D3BH73_POLPP/289-363 AC D3BH73.1
#=GS A0A8B7C2Y2_PHODC/608-688 AC A0A8B7C2Y2.1
#=GS RLF2_SCHPO/301-377 AC Q1MTN9.2
#=GS A0A0L0NIJ6_TOLOC/384-461 AC A0A0L0NIJ6.1
#=GS A0A1G4B8Q4_9PEZI/347-426 AC A0A1G4B8Q4.1
#=GS A0A1L0BF85_9ASCO/492-573 AC A0A1L0BF85.1
#=GS A0A7K5ZYI0_ONYCO/529-602 AC A0A7K5ZYI0.1
#=GS A0A376B8Y4_9ASCO/388-466 AC A0A376B8Y4.1
#=GS A0A179H822_PURLI/368-445 AC A0A179H822.1
#=GS A0A151TAX6_CAJCA/497-560 AC A0A151TAX6.1
#=GS A0A8P4GKK7_DICLA/502-576 AC A0A8P4GKK7.1
#=GS A0A1E4RIN4_9ASCO/349-422 AC A0A1E4RIN4.1
#=GS A0A0N0BHQ6_9HYME/472-511 AC A0A0N0BHQ6.1
#=GS A0A8H5BWW7_9AGAR/479-551 AC A0A8H5BWW7.1
#=GS E0VJD4_PEDHC/294-366 AC E0VJD4.1
#=GS A0A7K9VCI7_ANSSE/531-604 AC A0A7K9VCI7.1
#=GS A0A7L1PYS4_ORIOR/532-605 AC A0A7L1PYS4.1
#=GS A0A7K8UM23_OCEOC/534-607 AC A0A7K8UM23.1
#=GS A0A0M9F305_FUSLA/355-434 AC A0A0M9F305.1
#=GS A0A8B9ZBX5_9AVES/535-596 AC A0A8B9ZBX5.1
#=GS A0A7L0ZTX5_9PASS/529-602 AC A0A7L0ZTX5.1
#=GS A0A2A9PGX7_9HYPO/337-414 AC A0A2A9PGX7.1
#=GS A0A8H4QPN3_9AGAR/485-557 AC A0A8H4QPN3.1
#=GS A0A7K7UA63_9CHAR/532-605 AC A0A7K7UA63.1
#=GS B9RM13_RICCO/481-560 AC B9RM13.1
#=GS A0A395MPM5_9HYPO/369-447 AC A0A395MPM5.1
#=GS A0A0L0C4L2_LUCCU/726-799 AC A0A0L0C4L2.1
#=GS A0A4T0J2U9_WALIC/424-502 AC A0A4T0J2U9.1
#=GS A0A7K9HC71_9AVES/527-600 AC A0A7K9HC71.1
#=GS A0A166Y7C5_9PEZI/359-438 AC A0A166Y7C5.1
#=GS A0A5N5H587_9ROSA/492-563 AC A0A5N5H587.1
#=GS A0A7K8EMC4_LEURO/522-595 AC A0A7K8EMC4.1
#=GS A0A5C6MR20_9TELE/474-548 AC A0A5C6MR20.1
#=GS A0A8C5MAY1_9ANUR/350-412 AC A0A8C5MAY1.1
#=GS A0A8D0KT07_STROC/545-622 AC A0A8D0KT07.1
#=GS F9WJC0_TRYCI/384-472 AC F9WJC0.1
#=GS I3J2Y4_ORENI/339-414 AC I3J2Y4.2
#=GS A0A6J0TQY5_9SAUR/502-575 AC A0A6J0TQY5.1
#=GS A0A6A6Z4B3_9PEZI/308-384 AC A0A6A6Z4B3.1
#=GS A0A8J5W4J6_ZIZPA/588-664 AC A0A8J5W4J6.1
#=GS A0A0G4J018_PLABS/315-388 AC A0A0G4J018.1
#=GS A0A1S3PC47_SALSA/513-588 AC A0A1S3PC47.1
#=GS A0A803L429_CHEQI/482-551 AC A0A803L429.1
#=GS A0A4C1UKZ5_EUMVA/657-733 AC A0A4C1UKZ5.1
#=GS A0A5N7ARQ8_9EURO/431-507 AC A0A5N7ARQ8.1
#=GS A0A093XBX7_9PEZI/362-438 AC A0A093XBX7.1
#=GS A0A0A2JMX2_PENEN/388-464 AC A0A0A2JMX2.1
#=GS A0A7K7CCK7_APHCE/532-605 AC A0A7K7CCK7.1
#=GS A0A7J7KB54_BUGNE/435-507 AC A0A7J7KB54.1
#=GS A0A445DCG7_ARAHY/410-485 AC A0A445DCG7.1
#=GS A0A178F4G5_TRIRU/351-428 AC A0A178F4G5.1
#=GS A0A8B8LEA8_ABRPR/505-577 AC A0A8B8LEA8.1
#=GS A0A5C3PLJ7_9APHY/506-580 AC A0A5C3PLJ7.1
#=GS E3JVA1_PUCGT/500-574 AC E3JVA1.2
#=GS A0A7L3T5X2_RISTR/532-605 AC A0A7L3T5X2.1
#=GS V2XJH1_MONRO/450-526 AC V2XJH1.1
#=GS L8FV80_PSED2/367-443 AC L8FV80.1
#=GS A0A2T4BJW5_9HYPO/340-418 AC A0A2T4BJW5.1
#=GS A0A8J7NKS2_ATRSP/449-523 AC A0A8J7NKS2.1
#=GS A0A067THJ0_GALM3/477-549 AC A0A067THJ0.1
#=GS A0A8C7JLI2_ONCKI/428-489 AC A0A8C7JLI2.1
#=GS A0A176VXA5_MARPO/593-670 AC A0A176VXA5.1
#=GS A0A1C7N610_9FUNG/446-519 AC A0A1C7N610.1
#=GS A0A1V8TUS7_9PEZI/381-458 AC A0A1V8TUS7.1
#=GS F4PVY1_CAVFA/294-367 AC F4PVY1.1
#=GS A0A3Q1JMS7_ANATE/318-400 AC A0A3Q1JMS7.2
#=GS A0A4S3JG53_9EURO/303-379 AC A0A4S3JG53.1
#=GS A0A2T4ALN6_TRIHA/356-434 AC A0A2T4ALN6.1
#=GS A0A820RGB8_9BILA/292-370 AC A0A820RGB8.1
#=GS A0A485K8A5_9STRA/646-718 AC A0A485K8A5.1
#=GS A0A4S4LSQ2_9AGAM/475-551 AC A0A4S4LSQ2.1
#=GS A0A7L1TIC0_PHANI/543-616 AC A0A7L1TIC0.1
#=GS A0A383UT21_BLUHO/304-379 AC A0A383UT21.1
#=GS A0A4S2KLB6_9HYME/528-601 AC A0A4S2KLB6.1
#=GS A0A0D0CB17_9AGAR/443-518 AC A0A0D0CB17.1
#=GS A0A1L9SMN3_9EURO/350-426 AC A0A1L9SMN3.1
#=GS A0A8J2WH74_9CRUS/317-389 AC A0A8J2WH74.1
#=GS A0A7H8R4C1_9EURO/385-461 AC A0A7H8R4C1.1
#=GS A0A316W7Q2_9BASI/598-675 AC A0A316W7Q2.1
#=GS A0A8H2VRY5_9HELO/322-398 AC A0A8H2VRY5.1
#=GS A0A8H7MCZ3_9PLEO/339-415 AC A0A8H7MCZ3.1
#=GS R0JSS6_SETT2/336-412 AC R0JSS6.1
#=GS A0A3M0JJM1_HIRRU/531-604 AC A0A3M0JJM1.1
#=GS A0A8R1EGV0_CAEJA/4-78 AC A0A8R1EGV0.1
#=GS A0A1R1PNI6_ZANCU/200-280 AC A0A1R1PNI6.1
#=GS A0A6J3R9N6_TURTR/543-617 AC A0A6J3R9N6.1
#=GS A0A397ITI4_9GLOM/291-364 AC A0A397ITI4.1
#=GS A0A7R8UU51_HERIL/751-823 AC A0A7R8UU51.1
#=GS A0A6P3GI39_BISBI/542-616 AC A0A6P3GI39.1
#=GS A0A2K6JWR3_RHIBE/527-595 AC A0A2K6JWR3.1
#=GS A0A8H5MEV7_9AGAR/445-521 AC A0A8H5MEV7.1
#=GS I1I756_BRADI/603-680 AC I1I756.1
#=GS B7G639_PHATC/959-1033 AC B7G639.1
#=GS A0A815LWM7_9BILA/286-363 AC A0A815LWM7.1
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