GenomeNet

Database: Pfam
Entry: CD4-extracel
LinkDB: CD4-extracel
Original site: CD4-extracel 
#=GF ID   CD4-extracel
#=GF AC   PF09191.12
#=GF DE   CD4, extracellular
#=GF AU   Sammut SJ;0000-0003-4472-904X
#=GF SE   pdb_1cid
#=GF GA   26.00 26.00;
#=GF TC   26.10 26.00;
#=GF NC   25.70 25.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   CD4
#=GF CL   CL0011
#=GF RN   [1]
#=GF RM   8493535
#=GF RT   Crystal structure of domains 3 and 4 of rat CD4: relation to the
#=GF RT   NH2-terminal domains. 
#=GF RA   Brady RL, Dodson EJ, Dodson GG, Lange G, Davis SJ, Williams AF,
#=GF RA   Barclay AN; 
#=GF RL   Science. 1993;260:979-983.
#=GF DR   INTERPRO; IPR015274;
#=GF DR   SCOP; 1cid; fa;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Members of this family adopt an immunoglobulin-like
#=GF CC   beta-sandwich, with seven strands in 2 beta sheets, in a Greek
#=GF CC   key topology. They are predominantly found in the extracellular
#=GF CC   portion of CD4 proteins, where they enable interaction with
#=GF CC   major histocompatibility complex class II antigens [1].
#=GF SQ   148
#=GS F7ILX9_CALJA/205-315      AC F7ILX9.2
#=GS A0A091UGP9_PHORB/139-252  AC A0A091UGP9.1
#=GS A0A091UPT0_NIPNI/139-252  AC A0A091UPT0.1
#=GS A0A0Q3URE4_AMAAE/218-331  AC A0A0Q3URE4.1
#=GS A0A5E4B6T4_MARMO/204-310  AC A0A5E4B6T4.1
#=GS G3ULS8_LOXAF/226-330      AC G3ULS8.1
#=GS A0A1S3FR55_DIPOR/207-313  AC A0A1S3FR55.1
#=GS CD4_HUMAN/206-316         AC P01730.1
#=GS CD4_HUMAN/206-316         DR PDB; 1WIQ A; 181-291;
#=GS CD4_HUMAN/206-316         DR PDB; 5U1F M; 1181-1291;
#=GS CD4_HUMAN/206-316         DR PDB; 1WIQ B; 181-291;
#=GS CD4_HUMAN/206-316         DR PDB; 6MET A; 181-291;
#=GS CD4_HUMAN/206-316         DR PDB; 1WIP A; 181-291;
#=GS CD4_HUMAN/206-316         DR PDB; 1WIP B; 181-291;
#=GS CD4_HUMAN/206-316         DR PDB; 1WIO B; 181-291;
#=GS CD4_HUMAN/206-316         DR PDB; 1WIO A; 181-291;
#=GS CD4_HUMAN/206-316         DR PDB; 3T0E E; 181-291;
#=GS I3L556_PIG/245-352        AC I3L556.2
#=GS G3QL31_GORGO/206-316      AC G3QL31.1
#=GS K7GT07_PIG/208-315        AC K7GT07.1
#=GS M7B2Z9_CHEMY/144-256      AC M7B2Z9.1
#=GS M3W1W4_FELCA/238-344      AC M3W1W4.3
#=GS G3UL65_LOXAF/207-311      AC G3UL65.1
#=GS F6XGD3_MACMU/206-316      AC F6XGD3.3
#=GS G3TZC2_LOXAF/215-319      AC G3TZC2.1
#=GS A0A5N4C6H6_CAMDR/206-315  AC A0A5N4C6H6.1
#=GS CD4_MACMU/206-316         AC P16003.2
#=GS A0A672U131_STRHB/184-297  AC A0A672U131.1
#=GS A0A5E4B698_MARMO/204-310  AC A0A5E4B698.1
#=GS A0A2F0BI26_ESCRO/171-278  AC A0A2F0BI26.1
#=GS G3GUN9_CRIGR/207-313      AC G3GUN9.1
#=GS A0A3Q7W019_URSAR/214-319  AC A0A3Q7W019.1
#=GS A0A452SRG8_URSAM/223-328  AC A0A452SRG8.1
#=GS A0A673U8S3_SURSU/222-328  AC A0A673U8S3.1
#=GS A0A091VVS5_OPIHO/139-252  AC A0A091VVS5.1
#=GS CD4_RAT/209-315           AC P05540.1
#=GS CD4_RAT/209-315           DR PDB; 1CID A; 1-106;
#=GS A0A087RHA1_APTFO/139-252  AC A0A087RHA1.1
#=GS A0A2K6U8E4_SAIBB/205-315  AC A0A2K6U8E4.1
#=GS A0A091PV80_LEPDC/139-252  AC A0A091PV80.1
#=GS I6LI22_MUSPF/214-319      AC I6LI22.1
#=GS G3UBY8_LOXAF/206-310      AC G3UBY8.1
#=GS G5CAQ9_HETGA/193-300      AC G5CAQ9.1
#=GS W5P8J4_SHEEP/206-313      AC W5P8J4.1
#=GS L8Y3X9_TUPCH/229-335      AC L8Y3X9.1
#=GS CD4_RABIT/211-317         AC P46630.1
#=GS A0A093S7H6_PHACA/139-252  AC A0A093S7H6.1
#=GS I3NES8_ICTTR/204-310      AC I3NES8.1
#=GS A0A2Y9KVU3_ENHLU/215-320  AC A0A2Y9KVU3.1
#=GS A0A2Y9KWP3_ENHLU/215-320  AC A0A2Y9KWP3.1
#=GS A0A1S3WTS2_ERIEU/208-314  AC A0A1S3WTS2.1
#=GS A0A2U3WWZ7_ODORO/214-319  AC A0A2U3WWZ7.1
#=GS A0A452SRM0_URSAM/207-312  AC A0A452SRM0.1
#=GS A0A212CD61_CEREH/158-265  AC A0A212CD61.1
#=GS F1MJK4_BOVIN/206-313      AC F1MJK4.3
#=GS A0A663F4F2_AQUCH/197-309  AC A0A663F4F2.1
#=GS A0A093FFP9_GAVST/138-251  AC A0A093FFP9.1
#=GS A0A091J8V4_EGRGA/138-251  AC A0A091J8V4.1
#=GS A0A2Y9NP79_DELLE/206-313  AC A0A2Y9NP79.1
#=GS A0A452E3R1_CAPHI/206-313  AC A0A452E3R1.1
#=GS A0A643CBU4_BALPH/165-272  AC A0A643CBU4.1
#=GS A0A4U1FPN6_MONMO/206-313  AC A0A4U1FPN6.1
#=GS A0A2Y9E6V4_TRIMA/219-324  AC A0A2Y9E6V4.1
#=GS A0A091S3U4_NESNO/139-252  AC A0A091S3U4.1
#=GS L5KFG2_PTEAL/215-241      AC L5KFG2.1
#=GS A0A093CSY3_TAUER/139-252  AC A0A093CSY3.1
#=GS A0A2K5RGR6_CEBCA/205-315  AC A0A2K5RGR6.1
#=GS A0A455BEW1_PHYMC/206-313  AC A0A455BEW1.1
#=GS A0A091RAA2_MERNU/138-252  AC A0A091RAA2.1
#=GS A0A5F4D9E1_CANLF/213-319  AC A0A5F4D9E1.1
#=GS G3UCG3_LOXAF/209-313      AC G3UCG3.1
#=GS A0A091PM83_HALAL/137-249  AC A0A091PM83.1
#=GS A0A2K5YPB8_MANLE/206-316  AC A0A2K5YPB8.1
#=GS A0A2Y9RYS9_TRIMA/219-324  AC A0A2Y9RYS9.1
#=GS A0A093INP9_FULGA/139-252  AC A0A093INP9.1
#=GS A0A485MFW6_LYNPA/221-327  AC A0A485MFW6.1
#=GS A0A099ZZE9_CHAVO/139-252  AC A0A099ZZE9.1
#=GS A0A1U7Q3K5_MESAU/209-313  AC A0A1U7Q3K5.2
#=GS A0A2U3Y2Q1_LEPWE/214-319  AC A0A2U3Y2Q1.1
#=GS G1QAX4_MYOLU/209-315      AC G1QAX4.1
#=GS A0A6G1B4Q5_CROCR/138-244  AC A0A6G1B4Q5.1
#=GS A0A3L8S9T8_CHLGU/224-337  AC A0A3L8S9T8.1
#=GS A0A2Y9H3X9_NEOSC/214-319  AC A0A2Y9H3X9.1
#=GS F6Q6F6_BOVIN/206-313      AC F6Q6F6.1
#=GS A0A663F3B4_AQUCH/218-330  AC A0A663F3B4.1
#=GS A0A2K5YP95_MANLE/1-43     AC A0A2K5YP95.1
#=GS W5P8J5_SHEEP/206-313      AC W5P8J5.1
#=GS S7N841_MYOBR/214-320      AC S7N841.1
#=GS A0A2R9B4G7_PANPA/206-316  AC A0A2R9B4G7.1
#=GS A0A5F8A870_MACMU/27-137   AC A0A5F8A870.1
#=GS F1SLT4_PIG/208-315        AC F1SLT4.3
#=GS A7YY52_BOVIN/206-313      AC A7YY52.1
#=GS H2NG98_PONAB/162-272      AC H2NG98.1
#=GS A0A4X2JRA7_VOMUR/217-326  AC A0A4X2JRA7.1
#=GS A0A096MWA4_PAPAN/206-316  AC A0A096MWA4.1
#=GS A0A2K6F4V6_PROCO/207-313  AC A0A2K6F4V6.1
#=GS A0A672U0G2_STRHB/181-294  AC A0A672U0G2.1
#=GS A0A091MIH9_9PASS/138-247  AC A0A091MIH9.1
#=GS G1T4B9_RABIT/211-317      AC G1T4B9.1
#=GS A0A672TZQ4_STRHB/209-322  AC A0A672TZQ4.1
#=GS A0A2I0U4I8_LIMLA/217-330  AC A0A2I0U4I8.1
#=GS Q71QE2_TURTR/206-313      AC Q71QE2.1
#=GS K7G8F0_PELSI/203-311      AC K7G8F0.1
#=GS A0A2Y9RUH9_TRIMA/219-324  AC A0A2Y9RUH9.1
#=GS H0VL66_CAVPO/220-329      AC H0VL66.2
#=GS CD4_MACFA/206-316         AC P79185.1
#=GS A0A4W2CPG8_BOBOX/206-313  AC A0A4W2CPG8.1
#=GS A0A5J5N4F1_MUNRE/206-313  AC A0A5J5N4F1.1
#=GS CD4_PANTR/206-316         AC P16004.1
#=GS G3U7C0_LOXAF/209-313      AC G3U7C0.1
#=GS A0A671DTY9_RHIFE/215-320  AC A0A671DTY9.1
#=GS L8HVB0_9CETA/206-313      AC L8HVB0.1
#=GS A0A663F402_AQUCH/206-318  AC A0A663F402.1
#=GS A0A452IQE6_9SAUR/216-328  AC A0A452IQE6.1
#=GS A6MAP0_MONDO/215-322      AC A6MAP0.1
#=GS A0A093N9B7_PYGAD/139-252  AC A0A093N9B7.1
#=GS G7PJN3_MACFA/206-316      AC G7PJN3.1
#=GS G1QXL1_NOMLE/206-316      AC G1QXL1.1
#=GS A0A2K5E3A9_AOTNA/205-315  AC A0A2K5E3A9.1
#=GS CD4_MACNE/206-316         AC Q08340.2
#=GS A0A340Y8J8_LIPVE/205-312  AC A0A340Y8J8.1
#=GS A0A2K5MY49_CERAT/206-316  AC A0A2K5MY49.1
#=GS A0A383Z543_BALAS/206-313  AC A0A383Z543.1
#=GS H0XBR4_OTOGA/127-233      AC H0XBR4.1
#=GS A0A3Q7RWR8_VULVU/213-319  AC A0A3Q7RWR8.1
#=GS A0A0D9RD08_CHLSB/308-418  AC A0A0D9RD08.1
#=GS A0A2K5E3B4_AOTNA/152-262  AC A0A2K5E3B4.1
#=GS A0A5E4B7B3_MARMO/177-283  AC A0A5E4B7B3.1
#=GS A0A2K5K7H1_COLAP/206-316  AC A0A2K5K7H1.1
#=GS A0A091I8Q3_CALAN/138-250  AC A0A091I8Q3.1
#=GS S9XJK8_CAMFR/261-370      AC S9XJK8.1
#=GS A0A091CQ95_FUKDA/597-704  AC A0A091CQ95.1
#=GS A0A151MCU8_ALLMI/287-398  AC A0A151MCU8.1
#=GS A0A2K6NUB6_RHIRO/206-316  AC A0A2K6NUB6.1
#=GS G3TWZ4_LOXAF/209-313      AC G3TWZ4.1
#=GS A0A2K6DWJ0_MACNE/206-316  AC A0A2K6DWJ0.1
#=GS CD4_CERAT/179-289         AC Q08336.1
#=GS A0A3Q7VB55_URSAR/214-319  AC A0A3Q7VB55.1
#=GS A0A1A6HFA7_NEOLE/153-259  AC A0A1A6HFA7.1
#=GS A0A341AHR6_NEOAA/206-313  AC A0A341AHR6.1
#=GS A0A1U8DZG6_ALLSI/227-338  AC A0A1U8DZG6.1
#=GS A0A2K6M3L9_RHIBE/206-316  AC A0A2K6M3L9.1
#=GS F1SLT5_PIG/208-315        AC F1SLT5.2
#=GS A0A384BGT4_URSMA/214-319  AC A0A384BGT4.1
#=GS A0A6J3S3P7_TURTR/206-313  AC A0A6J3S3P7.1
#=GS CD4_CANLF/214-320         AC P33705.1
#=GS A0A5F9CA01_RABIT/211-317  AC A0A5F9CA01.1
#=GS G1Q929_MYOLU/205-311      AC G1Q929.1
#=GS G3WTA4_SARHA/233-343      AC G3WTA4.1
#=GS A0A091SDT1_9GRUI/138-252  AC A0A091SDT1.1
#=GS A0A287ACK9_PIG/245-352    AC A0A287ACK9.2
#=GS A0A0G3FB31_CERAT/206-316  AC A0A0G3FB31.1
#=GS CD4_MOUSE/210-316         AC P06332.1
#=GS CD4_DELLE/206-313         AC Q9XS78.1
#=GS F6Y6X8_HORSE/209-314      AC F6Y6X8.3
#=GS L5M931_MYODS/214-318      AC L5M931.1
#=GS G1M645_AILME/165-270      AC G1M645.1
#=GS A0A091KB69_COLST/139-252  AC A0A091KB69.1
F7ILX9_CALJA/205-315                 ...q-ASSTVYKKEGEQVEFSFPLAFAA....EQLt....gSG.ELCW.Q.AERASSSKSWITFNLTN.Q..EV.C.V.K.LVTQDPKLRM...GK...K..LP...FHLTLPQALPQYAGSGNFTLALKGktG..KLHQEVKLVV.
A0A091UGP9_PHORB/139-252             .dle----RKYATVDSTVTLSWCLNFQN....IKWke..gfAA.QLNW.K.QQKNATTHELLDFNITA.Q..EK.Q.H.KtKKSSRFRFEI...LE...R..GPegiIAVKLPKVHFNHSGQYQCQLVYKG..R..YTQKEIELVV.
A0A091UPT0_NIPNI/139-252             .dfe----RKYATVDSTVILSWRLNFQK....IDWke..gfTG.QLNW.K.QQENANAHELLDFNVTA.R.gKQ.H.E.T.KKSSRFRFEI...PE...S..KPestIEVKLPKVHFNHSGQYQCQLAYNG..R..HVQSKIELVV.
A0A0Q3URE4_AMAAE/218-331             .nle----RKYVTVGSAVILSWLLNFQKikwkEDF......TG.QLNW.K.QQGSATTHELFAFSITA.RgeQQ.E.I.K.K-SSHFGSEI...PE...S..XPdgtIQVKLPKVHFNHSGQYKCELAYKG..R..HVQSRIDLVV.
A0A5E4B6T4_MARMO/204-310             ...e-TLNTVYKKAGEQVELSFPLNIGD....EDL......RG.ELKW.Q.AERSSSSKTWVTFSLKN.K..HF.S.V.Q.KVTQDPKLQV...AE...N..LP...LRFTLSQALPQYAGSGDLTVTLDK..G..NLHKNVKLVV.
G3ULS8_LOXAF/226-330                 ...e-DSTTIYKKDGEQVKFSFPLTFKD....KDL......TG.ELKW.Q.AEGASSPKTWITFSLNN.K..KV.S.T.S.YIQK--RLQM...SE...A..LP...LSFTLPQALPQYAGFGNLTLDLAE..G..KLHQKVSLVV.
A0A1S3FR55_DIPOR/207-313             ..qm--VDTVYKAEGEPVQLSFPFNMND....ESL......NG.ELRW.R.AEGTSGSQPWLTFSLRS.G..KL.L.N.I.TVPQDPKLQV...PE...S..LP...IRVKLAKAQPKYAGSGNLTVKLAR..R..TLSQPLNLVV.
CD4_HUMAN/206-316                    ....KASSIVYKKEGEQVEFSFPLAFTV....EKLt....gSG.ELWW.Q.AERASSSKSWITFDLKN.K..EV.S.V.K.RVTQDPKLQM...GK...K..LP...LHLTLPQALPQYAGSGNLTLALEAktG..KLHQEVNLVV.
#=GR CD4_HUMAN/206-316         SS    ....-SEEEEEEETCS-EEEEE------....-SS-....EEE.EEEE.E.ESSSSS---EEEEEEBS.S..BE.E.E.E.EEETSST-BE...-S...S..SS...EEEEESSB-GGG-EEEEEEEEBTTTTE..EEEEEEEEEE.
I3L556_PIG/245-352                   ...k-VPSTVYVKEGDQVVLSFPLTFEA....ESL......SG.ELMWrQ.TKGASSPQSWITFSLKD.R..KV.T.V.Q.KSLQNLKLRM...AE...K..LP...LQITLLQALPQYAGSGNLTLVLPE..G..RLHREVNLVV.
G3QL31_GORGO/206-316                 ....KASSIVYKKEGEQVEFSFPLAFTV....EKLt....gSG.ELWW.Q.AERASSSKSWITFDLKN.K..EV.S.V.K.RVTQDPKLQM...GK...K..LP...LHLTLPQALPQYAGSGNLTLALEAktG..KLHQEVNLVV.
K7GT07_PIG/208-315                   ...k-VPSTVYVKEGDQVVLSFPLTFEA....ESL......SG.ELMWrQ.TKGASSPQSWITFSLKD.R..KV.T.V.Q.KSLQNLKLRM...AE...K..LP...LQITLLQALPQYAGSGNLTLVLPE..G..RLHREVNLVV.
M7B2Z9_CHEMY/144-256                 ..ln--QETLYKAVNSTVSFSYSLSTDL....QKIrkleyiTG.GLEW.K.SMADNKYREKFNFSVTS.K..EL.P.L.F.KQIANMQFTW...KL...I..NH...LEVKLPKVQFKDAGWYQCQLRVSR..G..RVEKAIHLVV.
M3W1W4_FELCA/238-344                 ....KVSNTVYAKEGEQVEFSFPLNFED....ENL......MG.NLRW.K.AEGAPSSLLWISFTLKN.K..QL.S.V.K.EVDPYSKLQM...MD...S..LP...LRFTLPNVLSRYAGSGNLTLVLDK..G..QLQQEVKLVV.
G3UL65_LOXAF/207-311                 ...e-DSTTIYKKDGEQVKFSFPLTFKD....KDL......TG.ELKW.Q.AEGASSPKTWITFSLNN.K..KV.S.T.S.YIQK--RLQM...SE...A..LP...LSFTLPQALPQYAGFGNLTLDLAE..G..KLHQKVSLVV.
F6XGD3_MACMU/206-316                 ....KASSTVYKKEGEQVEFSFPLAFTL....EKLt....gSG.ELWW.Q.AERASSSKSWITFDLKN.K..EV.S.V.K.RVTQDPKLQM...GK...K..LP...LHLTLPQALPQYAGSGNLTLALEAktG..KLHQEVNLVV.
G3TZC2_LOXAF/215-319                 ...e-DSTTIYKKDGEQVKFSFPLTFKD....KDL......TG.ELKW.Q.AEGASSPKTWITFSLNN.K..KV.S.T.S.YIQK--RLQM...SE...A..LP...LSFTLPQALPQYAGFGNLTLDLAE..G..KLHQKVSLVV.
A0A5N4C6H6_CAMDR/206-315             ....KVSSTVYAKEREQAVFSFPLTFED....ESL......SG.ELTWwP.AKRASSSESWITFSLKN.M..KV.S.V.E.TVRKDLKLQM...RE...K..LP...LHLTLPQALPQCAGSGKLTLVLTQ..GnrKLHQEVNLVV.
CD4_MACMU/206-316                    ....KASSTVYKKEGEQVEFSFPLAFTL....EKLt....gSG.ELWW.Q.AERASSSKSWITFDLKN.K..EV.S.V.K.RVTQDPKLQM...GK...K..LP...LHLTLPQALPQYAGSGNLTLALEAktG..KLHQEVNLVV.
A0A672U131_STRHB/184-297             .nle----RKYATVDSTVILSWLLNFQKikwkEDF......TG.QLNW.K.QQESATAHELLDFSVTA.R..GE.QhE.T.KKSSHFRFET...PE...S..KPegtIKVELPKVHFNHSGQYKCELAYKG..R..YVQSMIELVV.
A0A5E4B698_MARMO/204-310             ...e-TLNTVYKKAGEQVELSFPLNIGD....EDL......RG.ELKW.Q.AERSSSSKTWVTFSLKN.K..HF.S.V.Q.KVTQDPKLQV...AE...N..LP...LRFTLSQALPQYAGSGDLTVTLDK..G..NLHKNVKLVV.
A0A2F0BI26_ESCRO/171-278             ...e-VSSTVYAKEGEQMNFSFPLTFED....ENL......SG.ELCWlQ.AKGNSSPQSWITFTLKN.R..KV.T.V.E.KARKDLKLLM...SK...E..LP...LHLTLPRALPQYAGSGNLTLDLTK..G..KLYQEVNLVV.
G3GUN9_CRIGR/207-313                 ...n-SSTIVYKKEGEPAEFSFPLTFQD....ENL......QG.ELMW.R.AEKASSPGPWVTFSLEN.K..KV.A.V.L.KSWGTAKLQM...KE...E..LP...LHLKIHQVSLDNAGSGNLTLTLAK..G..KLRQEVNLVV.
A0A3Q7W019_URSAR/214-319             ....KVSNTVYTKEGDQVEFSFPLSFED....ENL......SG.ELRW.Q.AEGAPSSLLWSSFVLEN.R..KL.S.V.K.ELHV-PKLQL...KE...S..LP...LSFVLSQASSRYAGSGTLTLSLAK..G..TLQREVNLVV.
A0A452SRG8_URSAM/223-328             ....KVSNTVYTKEGDQVEFSFPLSFED....ENL......SG.ELRW.Q.AEGAPSSLLWSSFVLEN.R..KL.S.V.K.ELHV-PKLQL...KE...S..LP...LSFVLSQASSRYAGSGTLTLSLAK..G..TLQREVNLVV.
A0A673U8S3_SURSU/222-328             ....KVPNTIYSKEGEQVEFSFPINFED....ENL......MG.FLRW.E.AEEAPSSLLWVSFTLKN.K..KV.S.V.T.EVTHYPKLQM...KD...S..LP...LRFTLPNVSSGYAGSGNLTLTLDK..G..QLQQEVKLVV.
A0A091VVS5_OPIHO/139-252             .dfe----RQYAAVDSTVTLSWHLNFQK....IKWke..yfTG.QLNW.K.QQETAAAHELLDFNITE.R..EG.Q.H.EtKKSSHFRFEI...PE...S..KPkstIAVKLHKIHLNHSGQYQCQLVYNR..R..SVTSKIELVV.
CD4_RAT/209-315                      ...s-TSITAYKSEGESAEFSFPLNLGE....ESL......QG.ELRW.K.AEKAPSSQSWITFSLKN.Q..KV.S.V.Q.KSTSNPKFQL...SE...T..LP...LTLQIPQVSLQFAGSGNLTLTLDR..G..ILYQEVNLVV.
#=GR CD4_RAT/209-315           SS    ...X----EEEEETTS-EEEE-----SS....--E......EE.EEEE.E.ESS---S--EEEEEEET.T..EE.E.E.E.S---SS--EE...-S...B..TT...-EEEE-S--GGG-EEEEEEEE-SS..S..EEEEEEEEEE.
A0A087RHA1_APTFO/139-252             .dfe----RKYATVDSTVVLSWHLNFQK....IKWke..gfTG.QLNW.K.QHESAVAHELLDFNVTAgG..KQ.H.E.T.KKSSHFQFEIpgsKP...K..ST...IEVKLPKVHFNHSGQYQCQLAYNR..R..YVQSKIELVV.
A0A2K6U8E4_SAIBB/205-315             ...q-ASSTVYKKEGEQVEFSFPLAFAA....ETLt....gSG.ELCW.Q.AERASSSKSWITFNLTK.Q..EV.Y.V.K.LVTQDPKLRM...GK...K..LP...LHLTLAQALPQYAGSGNFTLALKGktG..KLHQEVNLVV.
A0A091PV80_LEPDC/139-252             .dle----RKYATVDSPVILSWHLNFQK....IKWke..gfTG.QLTW.K.QQENATSHELLDFNVTA.R..GE.Q.HeT.KKSRRFQFEI...PE...S..KPestIEVKLPKVYFNHSGQYQCQLVYNG..R..HMQSKIELVV.
I6LI22_MUSPF/214-319                 ....KVSNTVYSREGEQVKFSFPLNFEI....EKL......SG.ELRW.R.TEGAPSSLLWSSFTLEN.K..KL.F.V.K.EVHH-PRLQL...KE...T..LP...LSFILPQASSQYAGSGTLTLSLAK..G..TLQQEVNLVV.
G3UBY8_LOXAF/206-310                 ...e-DSTTIYKKDGEQVKFSFPLTFKD....KDL......TG.ELKW.Q.AEGASSPKTWITFSLNN.K..KV.S.T.S.YIQK--RLQM...SE...A..LP...LSFTLPQALPQYAGFGNLTLDLAE..G..KLHQKVSLVV.
G5CAQ9_HETGA/193-300                 ...k-SPRTAYKKEGEALELSFPLTFDD....EAH......LG.ELSW.R.ADRASSSQVWISFSVEN.R..KV.S.V.Q.MAALDPQLQM...AE...K..TP...LRLILSEALLQHAGSGNLTLTLAG..D.lKLHQEVNLVV.
W5P8J4_SHEEP/206-313                 ...k-APETVYVKEGEQAEFSFPLTFED....ENL......SG.ELTWqQ.ANKDSSSQSWVTFTLRN.R..EV.K.V.N.KTHKDVKLHM...GE...R..LP...LRLTLQRTLPQYAGSGTLTLDLTK..G..KLHQKVNLVV.
L8Y3X9_TUPCH/229-335                 ....KASMTLYKKEGERVDLSFPLTFED....EHL......RG.ELRW.Q.AERPPSSESWVSFSVQA.K..EV.T.V.Q.GSLPDLKLQM...AK...S..LP...LSITLPQAHLRHAGSGKLTLTLGK..G..QLQQDVNLVV.
CD4_RABIT/211-317                    ....KASATVYKKEGEQVEFSFPLNFED....ESL......SG.ELMW.Q.VDGASSAQSWVSFSLED.R..KV.S.V.Q.KILPDLKIQM...SK...G..LP...LSLTLPQALHRYAGSGNLSLTLDK..G..KLHQQVSLVM.
A0A093S7H6_PHACA/139-252             .dfe----RKYATVDSSVILSWHLNIQK....IKWek..glTG.QLYW.K.KQENETIHELLDFNVTA.Q.gQL.H.G.T.KKSSHFQFEI...PE...S..KPgstIEVKLPTVHFDHAGQYQCQLAYKG..R..NTQRKIELVV.
I3NES8_ICTTR/204-310                 ...e-TLNTVYKKVGEQVELSFPLNIGD....EDL......RG.ELKW.Q.AERSSSSKTWFTFSLKN.K..QF.S.V.Q.KVIQDPKLQV...AE...N..LP...LRFTLSHALPQYAGSGELTLTLDK..G..KLQKNVKLVL.
A0A2Y9KVU3_ENHLU/215-320             ....KVSNTVYTKEGEQVKFSFPLSFEI....ENL......SG.ELRW.R.AEGTPSSLLWSSFTLEN.K..KV.F.V.K.EVHH-PSLQL...KE...T..LP...LSFILPQASSQWAGSGTLTLSLAK..G..TLQQEVNLVV.
A0A2Y9KWP3_ENHLU/215-320             ....KVSNTVYTKEGEQVKFSFPLSFEI....ENL......SG.ELRW.R.AEGTPSSLLWSSFTLEN.K..KV.F.V.K.EVHH-PSLQL...KE...T..LP...LSFILPQASSQWAGSGTLTLSLAK..G..TLQQEVNLVV.
A0A1S3WTS2_ERIEU/208-314             ..da--TTIIYGRAQEKVLFHFPLNLEV....RSL......KG.MLSW.Q.PERPSSPKACVRFSLED.K..KV.T.V.T.NASLQPKFLV...EE...N..LP...LRVTLPLAKPEHAGSGKLFLNLTW..G..VLLKEVKLVV.
A0A2U3WWZ7_ODORO/214-319             ....KVSNTVYTKEGEQVEFSFPLNFED....ENL......SG.ELRW.Q.AEGTPSSRLWISFVLEN.G..KL.S.L.K.DT-HHARLQM...KG...F..PP...LSFILPQALSQYAGSGNLTLSLAK..G..TLQREVNLVV.
A0A452SRM0_URSAM/207-312             ....KVSNTVYTKEGDQVEFSFPLSFED....ENL......SG.ELRW.Q.AEGAPSSLLWSSFVLEN.R..KL.S.V.K.ELHV-PKLQL...KE...S..LP...LSFVLSQASSRYAGSGTLTLSLAK..G..TLQREVNLVV.
A0A212CD61_CEREH/158-265             ...k-APKTVYVKEGEQAEFSFPLTFED....ENL......HG.ELRWqQ.ANGDSSSQSWVTFTLTN.R..EV.K.V.L.KTAKDLRLLV...GE...R..LP...LRFTLLRTLPQYAGSGTLTLDLTK..G..KLQQEVKLVV.
F1MJK4_BOVIN/206-313                 ...k-APETVYVKEGEQAEFSFPLTFEY....ENL......SG.ELTW.QlANGDSSSQSWVTFTVKN.R..EV.K.V.N.KIHNDPKLLV...GE...K..LP...LRLTLPRTLPQHAGSGTLTLDLTK..G..KLQQKVKLVV.
A0A663F4F2_AQUCH/197-309             .tdl---ERKYATAGSTVILSWHLNFQK....IKWke..gfTG.QLNW.K.QQESATAHELLDFNVTA.R..GE.Q.H.EtKKSSRFQCEI...RK..pE..ST...IELKLPKVHFNHSGQYQCQLAYNR..R..YVQSKIELVV.
A0A093FFP9_GAVST/138-251             .dle----RKYAAVDSTVILSWSLNFQK....IKWke..gfTG.QLSW.K.QQENATTHELLDFNVTA.R..GEqH.R.T.KKGSHFRFEI...LE...N..KPestIEVKLPKVHFNHSGQYQCQLAYNG..R..SVQSKIELVV.
A0A091J8V4_EGRGA/138-251             .dle----RKYATVGSTVILSWHLNFQK....IKWke..gfTG.QLNW.K.QQESATPHELLDFNVTA.R..GE.K.HeT.KKSSHFWFEI...PE...S..KPksaIEVKLPKVHFNHSGQYQCQLAYNR..R..SVQSKIELVV.
A0A2Y9NP79_DELLE/206-313             ...e-VSSTVYAKEGEQMNFSFPLTFGD....ENL......SG.ELSWlQ.AKGNSSPESWITFKLNN.G..KV.T.V.G.KARKDLKLRM...SK...A..LP...LHLTLPQALPQYAGSGNLTLNLTK..G..KLYQEVNLVV.
A0A452E3R1_CAPHI/206-313             ...k-APETVYVKEGEQAEFSFPLTFED....ENL......SG.ELTWqQ.ANKDSSSQSWVTFTLRN.R..EV.K.V.N.KTHKDLKLRV...EE...R..LP...LRLTLLRTLPQYAGSGTLTLDLSK..G..KLHQKVNLVV.
A0A643CBU4_BALPH/165-272             ...e-VSSTVYAKEGEQMNFSFPLTFED....ENL......SG.ELCWlQ.AKGNSSPQSWITFTLKN.R..KV.T.V.E.KARKDLKLLM...SK...D..LP...LHLTLPRALPQYAGSGNLTLDLTK..G..KLYQEVNLVV.
A0A4U1FPN6_MONMO/206-313             ...e-VSSTVYAKEGEQMNFSFPLTFGD....ENL......SG.ELSWlQ.AKGNSSPESWITFKLNN.G..KV.T.V.G.KARKDLKLRM...SK...A..LP...LHLTLPQALPQYAGSGNLTLNLTK..G..KLYQEVNLVV.
A0A2Y9E6V4_TRIMA/219-324             ...k-DSNTIYKKNGEQVEFAFPLTFTN....EDL......TG.ELKW.Q.AEGASSPQTWITFSLKD.K..KV.S.P.T.SVIL-DKLKM...NK...T..LP...LCFTLPQALPQYAGFGNLTLDLAK..G..KLHQNVSLVV.
A0A091S3U4_NESNO/139-252             .nle----RKYATVDSTVILSWLLNFQKikwkEDF......TG.QLNW.K.QHESATAHELLDFSVTA.R..GE.QhE.T.KKSSHFLFEI...PE...S..KPegtIKVKLPKVHFNHSGQYKCELAYKG..R..YVQSTIELVV.
L5KFG2_PTEAL/215-241                 ....KVSNTVYAKEGEKVELSFPLTFED....ENL......--.----.-.-----------------.-..--.-.-.-.----------...--...-..--...------------------------..-..----------.
A0A093CSY3_TAUER/139-252             .dle----RKYATADSTVILSWHLNFQK....IKWka..gfTG.QLNW.K.QQESATAHELLDFNVTS.R..GE.QhE.T.KKSSRFRFEI...PE...R..KPdstIAVKLPKVHFNHSGQYQCQLAYHQ..R..HAQSKIELVV.
A0A2K5RGR6_CEBCA/205-315             ...q-ASSTVYKKEGEQVEFSFPLAFAA....ETLt....gSG.ELRW.Q.AERASSSKSWITFNLTN.K..EV.F.V.K.LVTQDPKLRM...GK...K..LP...LHLTLLQALPQYAGSGNLTLALKGktG..KLHQEVNLVV.
A0A455BEW1_PHYMC/206-313             ...e-VSSTVYAKDGEHMNFSFPLTFED....ENL......SG.ELRWlQ.AEGSSSPESWITFTSKN.K..VV.T.V.Q.NARKDLKLHL...NE...R..LP...LHLTLPRALPQYAGSGNLTLNLTK..G..KLSQEVNLVV.
A0A091RAA2_MERNU/138-252             ..pd--SERKYAAVDSTVVLSWDLNFQE....IKWkk..gfTG.QLSW.K.QQESATAHELLDFNVTE.Q..RK.Q.HeM.KKSSRFWFEI...PE...S..KPkstIQVKLPKVHFNHSGQYQCQLEYDR..A..YTQNKIELV-a
A0A5F4D9E1_CANLF/213-319             ....KVSNTFYAREGDQVEFSFPLSFED....ENL......VG.ELRW.Q.AQGASSSLLWISFTLEN.R..KL.S.M.K.EAHAPLKLQM...KE...S..LP...LRFTLPQVLSRYAGSGILTLNLAK..G..TLYQEVNLVV.
G3UCG3_LOXAF/209-313                 ...e-DSTTIYKKDGEQVKFSFPLTFKD....KDL......TG.ELKW.Q.AEGASSPKTWITFSLNN.K..KV.S.T.S.YIQK--RLQM...SE...A..LP...LSFTLPQALPQYAGFGNLTLDLAE..G..KLHQKVSLVV.
A0A091PM83_HALAL/137-249             tdle----RKYATADSTVILSWHLNFRK....IKWke..gfTG.QLNW.K.QQESATAHELLDFNVTA.R..GE.Q.H.EtKKSSRFQYEI...RK..pE..ST...IELKLPKVHFNHSGQYQCQLAYNR..R..YVQSKIELVV.
A0A2K5YPB8_MANLE/206-316             ....KASSTVYKKEGEQVEFSFPLAFTL....EKLt....gSG.ELWW.Q.AERASSSKSWITFDLKN.K..EV.S.V.K.WVTQDPKLQM...GK...K..LP...LHLTLPQALPQYAGSGNLTLALEAktG..KLHQEVNLVV.
A0A2Y9RYS9_TRIMA/219-324             ...k-DSNTIYKKNGEQVEFAFPLTFTN....EDL......TG.ELKW.Q.AEGASSPQTWITFSLKD.K..KV.S.P.T.SVIL-DKLKM...NK...T..LP...LCFTLPQALPQYAGFGNLTLDLAK..G..KLHQNVSLVV.
A0A093INP9_FULGA/139-252             .dle----RKYATVDSTVILSWNLNFQK....IKWke..gfTG.QLNW.K.QQEGATAHELLDFNVTA.R..GE.Q.Y.EsKKSSHFRFEI...PE...S..KPesiIEVKLPKVHFNHSGQYQCQLAYNR..R..YSQSKIELVV.
A0A485MFW6_LYNPA/221-327             ....KVSNTVYAKEGEQVEFSFPLNFED....ENL......MG.KLRW.K.AEGAPSSLLWISFTLEN.K..KL.S.V.K.EVDQYSKLQM...MD...S..LP...LRFTLPNVLSRYAGSGNLTLVLDK..G..QLQQEVKLVV.
A0A099ZZE9_CHAVO/139-252             .gle----RKYATVDSTVILSWHLNFQK....IKWkk..gfTG.QLKW.K.QQESTTTHELLDFNVTA.R..GE.K.HeT.KKSSHFRFEI...PE...S..KPentINVKLPKVHFNHSGQYQCQLAYNG..R..DTHSRIELVV.
A0A1U7Q3K5_MESAU/209-313             ....KTSTTVYTRDGESAEFSFPLNFGD....ENL......QG.ELKW.R.TEKDPSPSPWVTFSLEN.R..KV.T.M.A.KDT--RKLQM...AE...E..LP...LRLKILQVSLENAGSGNLTLTLAK..G..TLHQEVTLVV.
A0A2U3Y2Q1_LEPWE/214-319             ....KVSNTVYTKEGEQVEFSFPLNFKD....ENL......SG.ELRW.R.AEGAPSSLLWISFTLEN.E..KL.S.V.N.EVHH-PKLQM...KT...F..LP...LSFILPQALSQYAGSGTLTLSLAK..G..TLQQEVNLVV.
G1QAX4_MYOLU/209-315                 ...d-VSDTVYTKVGEPVEFSFPLTFED....ENL......VG.ELRW.Q.EEGTSSPQPWITFSLEN.R..KV.T.V.K.KVRKDRKIQL...KE...T..LP...LTFSLPQASLQDVGSGHLTLNLSQ..G..QLHQKVNLAV.
A0A6G1B4Q5_CROCR/138-244             ....KVSNTIYTKEGEQVEFSFPLNFEA....EDL......MG.NLSW.K.AEGAPSSQLWISFTLNN.K..KL.S.V.I.EANHNPKLQM...KD...S..LP...LCFTLPRVSSGYAGSGNLTLAVGN..G..QLQQEVKLVV.
A0A3L8S9T8_CHLGU/224-337             .dle----RKYATVDSTVILSWHLNSQN....IKLke..gfTG.QLNW.K.QQESAKSHKLLDFSVTA.Q.gQL.H.E.T.EKSNTFLFEI...PE...R..KPegtIEVKLPKVHFNHSGQYQCQLEYQG..R..HTQSKIELVV.
A0A2Y9H3X9_NEOSC/214-319             ....KVSNTVYTKEGEQVEFSFPLNFKD....ENL......SG.ELRW.R.AEGAPSSLLWISFTLEN.K..KL.S.V.K.EVHH-PKLQM...KT...F..LP...LSFILPQALSQYAGSGTLTLSLAK..G..TLQQEVNLVV.
F6Q6F6_BOVIN/206-313                 ...k-APETVYVKEGEQAEFSFPLTFEY....ENL......SG.ELTW.QlANGDSSSQSWVTFTVKN.R..EV.K.V.N.KIHNDPKLLV...GE...K..LP...LRLTLPRTLPQHAGSGTLTLDLTK..G..KLQQKVKLVV.
A0A663F3B4_AQUCH/218-330             .tdl---ERKYATAGSTVILSWHLNFQK....IKWke..gfTG.QLNW.K.QQESATAHELLDFNVTA.R..GE.Q.H.EtKKSSRFQCEI...RK..pE..ST...IELKLPKVHFNHSGQYQCQLAYNR..R..YVQSKIELVV.
A0A2K5YP95_MANLE/1-43                ....------------------------....---......--.----.-.-----------------.-..--.-.-.-.---------M...GK...K..LP...LHLTLPQALPQYAGSGNLTLALEAktG..KLHQEVNLVV.
W5P8J5_SHEEP/206-313                 ...k-APETVYVKEGEQAEFSFPLTFED....ENL......SG.ELTWqQ.ANKDSSSQSWVTFTLRN.R..EV.K.V.N.KTHKDVKLHM...GE...R..LP...LRLTLQRTLPQYAGSGTLTLDLTK..G..KLHQKVNLVV.
S7N841_MYOBR/214-320                 ...n-VSDTVYTKVGEPVEFSFPLTFED....ENL......VG.ELRW.R.EEGTSSLQSWITFSLEN.R..KV.T.V.K.KVRKDRKIQL...KE...T..LP...LTFSLPQASIQDVGSGHLTLNLSR..G..QLHQKVNLAV.
A0A2R9B4G7_PANPA/206-316             ....KASSIVYKKEGEQVEFSFPLAFTV....EKLt....gSG.ELWW.Q.AERASSSKSWITFDLKN.K..EV.S.V.K.RVTQDPKLQM...GK...K..LP...LHLTLPQALPQYAGSGNLTLALEAktG..KLHQEVNLVV.
A0A5F8A870_MACMU/27-137              ....KASSTVYKKEGEQVEFSFPLAFTL....EKLt....gSG.ELWW.Q.AERASSSKSWITFDLKN.K..EV.S.V.K.RVTQDPKLQM...GK...K..LP...LHLTLPQALPQYAGSGNLTLALEAktG..KLHQEVNLVV.
F1SLT4_PIG/208-315                   ...k-VPSTVYVKEGDQVVLSFPLTFEA....ESL......SG.ELMWrQ.TKGASSPQSWITFSLKD.R..KV.T.V.Q.KSLQNLKLRM...AE...K..LP...LQITLLQALPQYAGSGNLTLVLPE..G..RLHREVNLVV.
A7YY52_BOVIN/206-313                 ...k-APETVYVKEGEQAEFSFPLTFEY....ENL......SG.ELTW.QlANGDSSSQSWVTFTVKN.R..EV.K.V.N.KIHNDPKLLV...GE...K..LP...LRLTLPRTLPQHAGSGTLTLDLTK..G..KLQQKVKLVV.
H2NG98_PONAB/162-272                 ....KASSIVYKKEGEKVEFSFPLTFTV....ERLm....gSG.ELWW.Q.AERASSSKSWITFDLKN.K..EV.S.V.K.QVTQDPKLQM...GK...K..LP...LHLTLPQALPQYAGSGNLTLALEAktG..KLRQEVNLVV.
A0A4X2JRA7_VOMUR/217-326             ...s-SSQTFYLMKGKAAKFSFPLNLNE....QDLnr.eqpNG.ELRW.Q.VEGVASPPQSAKFSWKS.G..SL.I.L.E.NGAPN--FNR...DP...K..FP...LTITLSPVLPQHAGSGVFLLKFSS..G..TLEQKVNLVV.
A0A096MWA4_PAPAN/206-316             ....KASSTVYKKEGEQVEFSFPLAFTL....EKLt....gSG.ELWW.Q.AERASSSKSWITFDLKN.K..EV.S.V.K.WVTQDPKLQM...GK...K..LP...LHLTLPQALPQYAGSGNLTLALEAktG..KLHQEVNLVV.
A0A2K6F4V6_PROCO/207-313             ...k-APSTIYKKEGEQAEFSFPLTFEE....ENL......DG.ELRW.Q.AEGASSPKSWITFSLKN.K..KV.T.L.Q.GVTQDPKLQM...GE...T..FP...LRITLPQALPWYAGSGNLTLVLAE..G..QLHQEVKLVV.
A0A672U0G2_STRHB/181-294             .nle----RKYATVDSTVILSWLLNFQKikwkEDF......TG.QLNW.K.QQESATAHELLDFSVTA.R..GE.QhE.T.KKSSHFRFET...PE...S..KPegtIKVELPKVHFNHSGQYKCELAYKG..R..YVQSMIELVV.
A0A091MIH9_9PASS/138-247             .dle----RKYAAVDSTIILSWHLNFQK....IKWke..afTG.QLKW.K.EQKSTNTHELLDFNMTA.R..GQ.K.Q.E.TKKSSHILFE...TP...E..ST...IGVKLPKVHFNHSGQYQCQLAYKG..R..HVQSKIELVV.
G1T4B9_RABIT/211-317                 ....KASATVYKKEGEQVEFSFPLNFED....ESL......SG.ELMW.Q.ADGASSAQSWVSFSLED.R..KV.S.V.Q.KILPDLKIQM...SK...G..LP...LSLTLPQALHRYAGSGNLSLTLDK..G..KLHQQVSLVM.
A0A672TZQ4_STRHB/209-322             .nle----RKYATVDSTVILSWLLNFQKikwkEDF......TG.QLNW.K.QQESATAHELLDFSVTA.R..GE.QhE.T.KKSSHFRFET...PE...S..KPegtIKVELPKVHFNHSGQYKCELAYKG..R..YVQSMIELVV.
A0A2I0U4I8_LIMLA/217-330             ..dl---ERMYATVDSTVILSWRLNFQK....IKWke..gfTG.QLKW.T.QQENAIPHELLDFNVTA.R..GE.K.H.EtQKSSHFRFKI...PE...G..KPesnIEVKLPKVSFNHSGQYQCQLAYDR..R..HTQSKIELVV.
Q71QE2_TURTR/206-313                 ...e-VSSTVYAKEGEQMNFSFPLTFGD....ENL......SG.ELSWlQ.AKGNSSPESWITFTLNN.G..KV.T.V.G.KARKDLKLRM...SK...E..LP...LHLTLPQALPQYAGSGNLTLNLTK..G..KLYQEVKLVV.
K7G8F0_PELSI/203-311                 ..ln--QETVYTAVNSSANFSYQMNNIL....QEMtklkniRG.ALMW.K.SEGESEYREKFNFNFSS.G..SL.R.L.P.KQMANLQF--...--...T..AN...LQVKMPKVQFQDAGWYRCQLTLKQ..G..SVKKDIHLVV.
A0A2Y9RUH9_TRIMA/219-324             ...k-DSNTIYKKNGEQVEFAFPLTFTN....EDL......TG.ELKW.Q.AEGASSPQTWITFSLKD.K..KV.S.P.T.SVIL-DKLKM...NK...T..LP...LCFTLPQALPQYAGFGNLTLDLAK..G..KLHQNVSLVV.
H0VL66_CAVPO/220-329                 ..qi--PNPFYKKEKESLEMCFPLTFNN....EDLp....fTG.ELIW.R.ADKASSSHSWITFSVAN.Q..RV.S.V.Q.NDNQDPKLQM...AE...K..TP...LCLTLSSVLLQHAGSGNLTLTLDG..G.qRLSQEVKLVV.
CD4_MACFA/206-316                    ....KASSTVYKKEGEQVEFSFPPAFTL....EKLt....gSG.ELWW.Q.AERASSSKSWITFDLKN.K..EV.S.V.K.RVTQDPKLQM...GK...K..LP...LHLTLPQALPQYAGSGNLTLALEAktG..KLHQEVNLVV.
A0A4W2CPG8_BOBOX/206-313             ...k-APETVYVKEGEQAEFSFPLTFEY....ENL......SG.ELTW.QlANGDSSSQSWVTFTVKN.R..EV.K.V.N.KIHNDPKLLV...GE...K..LP...LRLTLPRTLPQHAGSGTLTLDLTK..G..KLQQKVKLVV.
A0A5J5N4F1_MUNRE/206-313             ...k-APKTVYVKEGEQAEFSFPLTFED....ENL......SG.ELSWeQ.ANGDSSSQSWVTFTLTN.R..EV.K.V.L.KTHKDLKFLV...GE...R..LP...LHFTLLRTLPQYAGSGILTLDLTK..G..TLRQEVKLVV.
CD4_PANTR/206-316                    ....KASSIVYKKEGEQVEFSFPLAFTV....EKLt....gSG.ELWW.Q.AERASSSKSWITFDLKN.K..EV.S.V.K.RVTQDPKLQM...GK...K..LP...LHLTLPQALPQYAGSGNLTLALEAktG..KLHQEVNLVV.
G3U7C0_LOXAF/209-313                 ...e-DSTTIYKKDGEQVKFSFPLTFKD....KDL......TG.ELKW.Q.AEGASSPKTWITFSLNN.K..KV.S.T.S.YIQK--RLQM...SE...A..LP...LSFTLPQALPQYAGFGNLTLDLAE..G..KLHQKVSLVV.
A0A671DTY9_RHIFE/215-320             ....KVSDTVYAKEGEQVEFSLGLTCEN....INL......KG.ELKW.Q.KEGASSPKSCISFSLEN.K..KV.S.V.N.V-HQDCKFQM...KE...T..LP...FYISLPQASHQDAGSGNLTLLLSK..R..QLHQEVKLVM.
L8HVB0_9CETA/206-313                 ...k-APETVYVKEGEQAEFSFPLTFEY....ENL......SG.ELTW.QlANGDSSSQSWVTFTVKN.R..EV.K.V.N.KIHKDLKLLV...GE...K..LP...LHLTLPRTLPQHAGSGTLTLDLTK..G..KLQQKVNLVV.
A0A663F402_AQUCH/206-318             .tdl---ERKYATAGSTVILSWHLNFQK....IKWke..gfTG.QLNW.K.QQESATAHELLDFNVTA.R..GE.Q.H.EtKKSSRFQCEI...RK..pE..ST...IELKLPKVHFNHSGQYQCQLAYNR..R..YVQSKIELVV.
A0A452IQE6_9SAUR/216-328             ..ln--QETLYKAVNSTVSFSYSLSTHL....LQIre.leyVGvGLEW.K.PMIDSKYQEKFKFNVTS.K..EL.L.L.S.KQMANMQVTW...KP...S..NP...LEVKLPKVQFEDAGWYQCQLTVSR..G..RVEKAIHLVV.
A6MAP0_MONDO/215-322                 ...h-PYQRYYKIAGKDAEFNFPLNLGE....QDLnr.mvpNG.ELTW.H.GEGAAS-QRLAKFSWKD.D..SL.T.L.E.D---KFKFKL...SK...G..RP...ITLSLSPVLLHHAGSGVFSLMLPS..G..TVKQKVDLVV.
A0A093N9B7_PYGAD/139-252             .dfe----RKYATVDSTVVLSWHLNFQK....ITWke..gfTG.QLNW.K.QQESAIARELLDFNVTAgG..KQ.H.E.T.KKSSHFQFEI...SG...S..KPestIAVKLPKVHFNHSGQYQCQLAYNR..R..YVQSKIELVV.
G7PJN3_MACFA/206-316                 ....KASSTVYKKEGEQVEFSFPLAFTL....EKLt....gSG.ELWW.Q.AERASSSKSWITFDLKN.K..EV.S.V.K.RVTQDPKLQM...GK...K..LP...LHLTLPQALPQYAGSGNLTLALEAktG..KLHQEVNLVV.
G1QXL1_NOMLE/206-316                 ....KASSTVYKKEGEQVEFSFPLAFTV....EKLt....gSG.ELCW.Q.AERASSSKSWITFDLKN.K..EV.S.V.K.RVTQDPKLQM...DK...K..LP...LHLTLPQALPQYAGSGNLTLDLEAktG..KLRQEVNLVV.
A0A2K5E3A9_AOTNA/205-315             ...q-ASSTVYKKEGEQVEFSFPLAFAA....EKLt....gSG.ELCW.Q.AEKASSSKSWISFNLTS.Q..EV.C.V.K.VVTQDPKLRM...GK...K..LP...LHLTLPQALPQYAGSGNFTLALKGktG..KLHQKVNLVV.
CD4_MACNE/206-316                    ....KASSTVYKKEGEQVEFSFPLAFTL....EKLt....gSG.ELWW.Q.AERASSSKSWITFDLKN.K..EV.S.V.K.RVTQDPKLQM...GK...K..LP...LHLTLPQALPQYAGSGNLTLALDAktG..KLHQEVNLVV.
A0A340Y8J8_LIPVE/205-312             ...e-VSSTVYAKEGEQMNFSFPLTFED....ENL......SG.ELSWlQ.ANGNSSPQSWITFRLNK.K..TV.T.V.G.KTRKDLKLRM...SK...G..LP...LHLTLPQALPQYAGSGNLTLNLTK..G..KLYQEVNLVV.
A0A2K5MY49_CERAT/206-316             ....KASSTVYKKEGEQVEFSFPLAFTL....EELt....gSG.ELWW.Q.AERASSSKSWITFDLKN.K..EV.S.V.K.RVTQDPKLQM...GK...K..LP...LHLTLPQALPQYAGSGNLTLALEA..KteKLHQEVNLVV.
A0A383Z543_BALAS/206-313             ...e-VSSTVYAKEGEQMNFSFPLTFED....ENL......SG.ELCWlQ.AEGNSSPQSWITFTLKN.R..KV.T.V.E.KARKDLKLLM...SQ...Q..LP...LHLTLPRALPQYAGSGNLTLHLTK..G..KLYQEVNLVV.
H0XBR4_OTOGA/127-233                 ...g-ASSAIYKKEGEQVEFSFPLTFKE....ERL......EG.ELRW.Q.AEKASSSKPWVTFFLEN.N..KV.S.V.K.WITQDPKLQM...EE...T..LP...LRFTLPQALPQYAGSGNLTLVITS..R..KLQQEVKLVV.
A0A3Q7RWR8_VULVU/213-319             ....KVSNTFYAREGDQVEFSFPLSFED....ENL......VG.ELRW.Q.AQGASSSLLWISFTLEN.K..KL.S.M.K.EAHAPLKLQM...KE...S..LP...LRFTLPHALSRYAGSGTLTLNLAK..G..TLYQKVNLVV.
A0A0D9RD08_CHLSB/308-418             ....KASSTVYKKEGEQVEFSFPLAFTL....EKLt....gSG.ELWW.Q.AERASSSKSWITFDLKN.K..EV.S.V.K.QVTQDPKLQM...GK...K..LP...LNLTLPQALPQYAGSGNLTLALEAktG..KLHQEVNLVV.
A0A2K5E3B4_AOTNA/152-262             ...q-ASSTVYKKEGEQVEFSFPLAFAA....EKLt....gSG.ELCW.Q.AEKASSSKSWISFNLTS.Q..EV.C.V.K.VVTQDPKLRM...GK...K..LP...LHLTLPQALPQYAGSGNFTLALKGktG..KLHQKVNLVV.
A0A5E4B7B3_MARMO/177-283             ...e-TLNTVYKKAGEQVELSFPLNIGD....EDL......RG.ELKW.Q.AERSSSSKTWVTFSLKN.K..HF.S.V.Q.KVTQDPKLQV...AE...N..LP...LRFTLSQALPQYAGSGDLTVTLDK..G..NLHKNVKLVV.
A0A2K5K7H1_COLAP/206-316             ....KVSSTVYKKEGEQVEFSFPLTFTV....EKLt....gSG.ELRW.R.AEKASSSKSWITFDLKN.K..EV.S.V.K.RVTQDPKLQM...GK...N..LP...LYLTLPQALPQYAGSGNLTLALEAktG..KLHQEVNLVV.
A0A091I8Q3_CALAN/138-250             dlvr-----KYATVDSSVTLSWCLNFQK....IKWke..gfTG.KLNL.K.QEENASAYELLDFNVTA.Q..KQ.H.E.T.KKSRHFQFEI...PE...R..KPestIEVKLPKVHFNHSGQYECQLAYNG..R..YTQSNIELVV.
S9XJK8_CAMFR/261-370                 ....KVSSTVYAKEREQAVFSFPLTFED....ESL......SG.ELTWwP.AKRASSSESWITFSLKN.M..KV.S.V.E.TVRKDLKLQM...RE...K..LP...LHLTLPQALPQCAGSGKLTLVLTQ..GnrKLHQEVNLVV.
A0A091CQ95_FUKDA/597-704             ....KSSSTAYRKEGEALELSFPLTFED....EAL......VG.ELSW.R.ADRALSSQVWVSFSVEN.R..KV.T.V.Q.AAAQDPKLQV...AE...K..TP...LCLTLSKALLQHAGSGNLTLTLAG..G.lKLCQEVHLVV.
A0A151MCU8_ALLMI/287-398             ...e--SEIQYAAVNTTASFSYSLNLQE....VRWtg..sfKG.RLDW.K.AKTNDKYQEIMNFNFTN.Q..RL.T.L.P.KQIKHFGFKG...DE...KsfSK...LDVELSKVLFEDAGWYQCRVTFDF..G..HVETAIHLVV.
A0A2K6NUB6_RHIRO/206-316             ....KVSSTVYKKEGEQVEFSFPLTFTV....EKLm....gSG.ELWW.Q.AEKASSSKSWITFDLKN.K..EV.S.V.K.RVTQDPKLQM...GK...N..LP...LYLTLPQALPQYAGSGNLTLALEAktG..KLHQEVNLVV.
G3TWZ4_LOXAF/209-313                 ...e-DSTTIYKKDGEQVKFSFPLTFKD....KDL......TG.ELKW.Q.AEGASSPKTWITFSLNN.K..KV.S.T.S.YIQK--RLQM...SE...A..LP...LSFTLPQALPQYAGFGNLTLDLAE..G..KLHQKVSLVV.
A0A2K6DWJ0_MACNE/206-316             ....KASSTVYKKEGEQVEFSFPLAFTL....EKLt....gSG.ELWW.Q.AERASSSKSWITFDLKN.K..EV.S.V.K.RVTQDPKLQM...GK...K..LP...LHLTLPQALPQYAGSGNLTLALEAktG..KLHQEVNLVV.
CD4_CERAT/179-289                    ....KASSTVYKKEGEQVEFSFPLAFTL....EELt....gSG.ELWW.Q.AERASSSKSWITFDLKN.K..EV.S.V.K.RVTQDPKLQM...GK...K..LP...LHLTLPQALPQYAGSGNLTLALEA..KteKLHQEVNLVV.
A0A3Q7VB55_URSAR/214-319             ....KVSNTVYTKEGDQVEFSFPLSFED....ENL......SG.ELRW.Q.AEGAPSSLLWSSFVLEN.R..KL.S.V.K.ELHV-PKLQL...KE...S..LP...LSFVLSQASSRYAGSGTLTLSLAK..G..TLQREVNLVV.
A0A1A6HFA7_NEOLE/153-259             ....KTSTTVYKNEGESVEFSFPLNFGE....ESL......KG.ELRW.R.AEKAPAPQPWVTFSLEN.K..KV.S.V.G.KTRDNLKLKM...EE...S..LP...LRLKIAQVSLESAGSGNLTLTLAK..G..TLHQEVNLVV.
A0A341AHR6_NEOAA/206-313             ...e-VSSTVYAKEGEQMNFSFPLTFGD....ENL......SG.ELSWlQ.AKGNCSPESWITFKLNN.G..KV.T.V.G.KARKDLKLHM...SK...G..LP...LRLTLPQALPQYAGSGNLTLNLTK..G..KLYQEVNLVV.
A0A1U8DZG6_ALLSI/227-338             ..es---EIRYAAVNTTASFSYSLNLQE....VRWtg..sfKG.HLDW.K.AKTNDKYQEIMNFNFTN.Q..KL.T.L.P.KQIKRFGFKG...DE...KsfSS...LDVELSKVLFEDAGWYQCRITFDF..G..HVETAIHLVV.
A0A2K6M3L9_RHIBE/206-316             ....KVSSTVYKKEGEQVEFSFPLTFTV....EKLm....gSG.ELWW.Q.AEKASSSKSWITFDLKN.K..EV.S.V.K.RVTQDPKLQM...GK...N..LP...LYLTLPQALPQYAGSGNLTLALEAktG..KLHQEVNLVV.
F1SLT5_PIG/208-315                   ...k-VPSTVYVKEGDQVVLSFPLTFEA....ESL......SG.ELMWrQ.TKGASSPQSWITFSLKD.R..KV.T.V.Q.KSLQNLKLRM...AE...K..LP...LQITLLQALPQYAGSGNLTLVLPE..G..RLHREVNLVV.
A0A384BGT4_URSMA/214-319             ....KVSNTVYTKEGDQVEFSFPLSFED....ENL......SG.ELRW.Q.AEGAPSSLLWSSFVLEN.R..KL.S.V.K.ELHV-PKLQL...KE...S..LP...LSFVLSQASSRYAGSGTLTLSLAK..G..TLQREVNLVV.
A0A6J3S3P7_TURTR/206-313             ...e-VSSTVYAKEGEQMNFSFPLTFGD....ENL......SG.ELSWlQ.AKGNSSPESWITFTLNN.G..KV.T.V.G.KARKDLKLRM...SK...E..LP...LHLTLPQALPQYAGSGNLTLNLTK..G..KLYQEVKLVV.
CD4_CANLF/214-320                    ....KVSNTFYAREGDQVEFSFPLSFED....ENL......VG.ELRW.Q.AQGASSSLLWISFTLEN.R..KL.S.M.K.EAHAPLKLQM...KE...S..LP...LRFTLPQVLSRYAGSGILTLNLAK..G..TLYQEVNLVV.
A0A5F9CA01_RABIT/211-317             ....KASATVYKKEGEQVEFSFPLNFED....ESL......SG.ELMW.Q.ADGASSAQSWVSFSLED.R..KV.S.V.Q.KILPDLKIQM...SK...G..LP...LSLTLPQALHRYAGSGNLSLTLDK..G..KLHQQVSLVM.
G1Q929_MYOLU/205-311                 ...d-VSDTVYTKVGEPVEFSFPLTFED....ENL......VG.ELRW.Q.EEGTSSPQPWITFSLEN.R..KV.T.V.K.KVRKDRKIQL...KE...T..LP...LTFSLPQASLQDVGSGHLTLNLSQ..G..QLHQKVNLAV.
G3WTA4_SARHA/233-343                 ...s-PSQTIYGMTGKTVQFSFPLNLNE....QELnk.enpKG.EFTW.Q.VEGVASPQQPAKYSWKD.N..NL.T.P.K.NGIPNFKAE-...KS...N..FA...ITFTLSPVLPQHAGSGVFLLKFSS..G..DLKQKVKLVV.
A0A091SDT1_9GRUI/138-252             ..pd--SERKYATVGSTVILSWHLNFQK....IKWer..gfTG.QLNW.K.QQANATTHKLLDFNVTA.Q..RE.Q.H.KtKKRSHFWFEI...LEskpE..SP...IEVKLPKVHFNSSGQYQCQLAYDT..R..STQSEIELVV.
A0A287ACK9_PIG/245-352               ...k-VPSTVYVKEGDQVVLSFPLTFEA....ESL......SG.ELMWrQ.TKGASSPQSWITFSLKD.R..KV.T.V.Q.KSLQNLKLRM...AE...K..LP...LQITLLQALPQYAGSGNLTLVLPE..G..RLHREVNLVV.
A0A0G3FB31_CERAT/206-316             ....KASSTVYKKEGEQVEFSFPLAFTL....EELt....gSG.ELWW.Q.AERASSSKSWITFDLKN.K..EV.S.V.K.RVTQDPKLQM...GK...K..LP...LHLTLPQALPQYAGSGNLTLALEA..KteKLHQEVNLVV.
CD4_MOUSE/210-316                    ..st--AITAYKSEGESAEFSFPLNFAE....ENG......WG.ELMW.K.AEKDSFFQPWISFSIKN.K..EV.S.V.Q.KSTKDLKLQL...KE...T..LP...LTLKIPQVSLQFAGSGNLTLTLDK..G..TLHQEVNLVV.
CD4_DELLE/206-313                    ...e-VSSTVYAKEGEQMNFSFPLTFGD....ENL......SG.ELSWlQ.AKGNSSPESWITFKLNN.G..KV.T.V.G.KARKDLKLRM...SK...A..LP...LHLTLPQALPQYAGSGNLTLNLTK..G..KLYQEVNLVV.
F6Y6X8_HORSE/209-314                 ....KVSRTVYAKEGTQAEFSFPLTFAD....ENL......SG.ELQW.Q.AEGASSQQKWISFSSDN.R..KV.S.V.T.GVSSHLKLQV...EE...M..LP...LRFKLLQALPKHAGSGKLRLFLE-..G..ELQQEVNLVV.
L5M931_MYODS/214-318                 ...n-ISDTVYTKVGEPVEFSFPLTFDD....ENL......VG.ELRW.Q.EEGTSSPRPWITFSLEN.R..KV.T.V.K.KFQK--KIQL...KE...T..LP...LTFSLPQASLQDVGSGLLTLNLSQ..G..QLHQKVNLAV.
G1M645_AILME/165-270                 ....KVSNTVYTKEGDQVEFSFPLSFED....ENL......SG.ELRW.Q.AEGAPSSLLWSSFVLEN.R..KL.S.V.K.ELHV-PKLQL...KE...S..LP...LSFILSQASSRYAGSGTLTLSLAK..G..TLQREVNLVV.
A0A091KB69_COLST/139-252             ..dl---ETKYATVDSPVILSWHLNFQE....IKWkg..gfTG.KLIW.K.QQESATFQELLHFSITA.Q.gEL.N.E.T.KKSSRFNFEI...PQ...N..KPkstIEIKLLKVHFSQSGQYQCELAYNG..R..QVQSKIELVV.
#=GC SS_cons                         ...X-SEEEEEEETCS-EEEEE----SS....-SC.....EEE.EEEE.E.ESSSSSS--EEEEEEET.T..EE.E.E.E.CEETSST-EE...-S...C..TT...EEEEESSB-GGG-EEEEEEEEBTTTTC..EEEEEEEEEE.
#=GC seq_cons                        .....sSsTlYtKEGEQVcFSFPLsFpc....EsL......oG.ELpW.Q.ActuSSupsWloFsLcN.+..cV.o.V.p.+hppc.KLph...sc...p..LP...LcloLPpALsQaAGSGsLTLsLsp..G..pLpQcVsLVV.
//
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