#=GF ID   CEP1-DNA_bind
#=GF AC   PF09287.11
#=GF DE   CEP-1, DNA binding
#=GF AU   Sammut SJ;0000-0003-4472-904X
#=GF SE   pdb_1t4w
#=GF GA   24.40 24.40;
#=GF TC   25.30 24.40;
#=GF NC   24.30 23.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   15242600
#=GF RT   Structural differences in the DNA binding domains of human p53
#=GF RT   and its C. elegans ortholog Cep-1. 
#=GF RA   Huyen Y, Jeffrey PD, Derry WB, Rothman JH, Pavletich NP,
#=GF RA   Stavridi ES, Halazonetis TD; 
#=GF RL   Structure. 2004;12:1237-1243.
#=GF DR   INTERPRO; IPR015367;
#=GF DR   SCOP; 1t4w; fa;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Members of this family of DNA-binding domains are found the
#=GF CC   transcription factor CEP-1. They adopt a beta sandwich
#=GF CC   structure, with nine strands in two beta-sheets, in a Greek-key
#=GF CC   topology [1].
#=GF SQ   8
#=GS G0NLL7_CAEBE/62-262       AC G0NLL7.1
#=GS A0A2G5VE57_9PELO/237-431  AC A0A2G5VE57.1
#=GS E3LYA3_CAERE/201-398      AC E3LYA3.1
#=GS A0A2H2IAQ3_CAEJA/253-456  AC A0A2H2IAQ3.1
#=GS A0A1I7UL40_9PELO/232-431  AC A0A1I7UL40.1
#=GS CEP1_CAEBR/238-432        AC A8WW61.2
#=GS CEP1_CAEEL/223-418        AC Q20646.2
#=GS CEP1_CAEEL/223-418        DR PDB; 1T4W A; 223-418;
#=GS A0A261BNM3_9PELO/219-416  AC A0A261BNM3.1
G0NLL7_CAEBE/62-262                  ........................................ekfl---MDISVIEARASKKSDLAYKDFGE-NKILWTKPKCKVPVVVQWKSHSLVN..NRDLSLRIRLVNYLKKHEMENAIRDPAANVLKCQNHIDEEL..R.MPRESF....FYVVHSTVPWVcsvenLNYPRGFEYSTR..IKAGINEVNFDIMFMCQKNCMIIEDKRKTMCLAAFLEDENGNEISFSVIEEVHIHGYPQRDCKNFCGK-----lptfh
A0A2G5VE57_9PELO/237-431             ...........................................n-EWLTFEVKKERASKVSDFEFETVVNDGTYLWAKMKCNIPFIVKWNVSSCH-..-KQLFLKVRLANYMSSDNIENAIRVP-SNLTKCHKHSMAEV..K.TPQESF....FYIVNSSENWTp...lINSKKDQCFIAK..LAPGTTEIPFDLIFKCQRSCLDLEERRKRMCLAVFLEDENGNELLHDVIKQLLIVGYPRRDWKNFCEKRGDFK.....
E3LYA3_CAERE/201-398                 .........................................tyg---MEMDVMTERSSKVSNLAYLVTNAGEKHLWSKMQCNVPIELRWNIPSCLA..QKKLWLKIRLVNYDNSTDLQIAIRNPKADVAKCRKHIEEET..R.IPPGAF....FYIANSGHHWQp..hlNGSNGGYTLSTI..INPGTFSIAFDLIFMCQKMCMGIEDKRKSACLAAFLEDELKNEIHHAVIDQVYVVGYPRRDCNNFREK-----lpgf.
A0A2H2IAQ3_CAEJA/253-456             ...........................................g-DFLTMQVNEAKTKKISDFVSKQMPNGDAYLWTRMDVLVPIEVRWKVDKARIgnSSNLALRVRLVHYDRLLPIENAIHKANTDVKKCRDHTMKEA..DgVPAESF....FYILNSGTHWThasvtEKIVKGHSFRTV..VPSGKNGLDFDLRFTCQEKCMELDEKRKTMCLVVFLEDENGRPINHRVLKEVRVVAYPRRDYKNFCLKAD---gey..
A0A1I7UL40_9PELO/232-431             ............................................EEFMRITVLHDKASRQSDLAYMETGNNKKHLWAKMNCKVPIALKWKIDSRRV..DKKLWLRVRLVNYQNN-DVSRSLRDPTTDVLKCLHHINEER..L.DPPESY....FYVINSNLPWKcrvsdLRNGKGRHFIVQ..VDPNTTEATFDVMFMCQKNCMVVEDKRKPMSLAVLLEDRIGQAVMYAAIEDVQIVGYPSRDYRNFCSKLKE--fh...
CEP1_CAEBR/238-432                   ............................................EEWLTFEVKKERASKVSDFEFETVVNDGIYLWAKMKCNIPFIVKWNVSSCH-..-KQLFLKVRLVNYMASDNIENSIRVP-SNLAKCHNHRMTEE..K.TPRESF....FYVVKSGEHWTp...qINSKKDQCFVAK..LAPGTTQVLFDLIFKCQRSCLDLAERRKRMCLAVFLEDENGNELLHDVIKQLLIVGYPRRDWKNFCEKRGDFK.....
CEP1_CAEEL/223-418                   ............................................EKWMEIDVLKQKVAKSSDMAFAISSEHEKYLWTKMGCLVPIQVKWKLDKRHF..NSNLSLRIRFVKYDKKENVEYAIRNPRSDVMKCRSHTEREQ..H.FPFDSF....FYIRNSEHEFS.....YSAEKGSTFTLI..MYPGAVQANFDIIFMCQEKCLDLDDRRKTMCLAVFLDDENGNEILHAYIKQVRIVAYPRRDWKNFCEREDAKQ.....
#=GR CEP1_CAEEL/223-418        SS    ............................................--EEEEEE-HHHHTT-SSEEEEE-TT--EEEEE-TT--EEEEEEEE--TTTT..T---EEEEEEEEE-SSS-HHHHTT-TT-B----HHHHHT--..S.SSTT-S....EEEES-SSEEE.....EE-TTSSEEEEE..--TT--EEEEEEEESS-GGGS-HHHHTSEEEEEEEEE-TTS-EEEEEEEEEEEE-S-HHHHHHHHHHHHHH--.....
A0A261BNM3_9PELO/219-416             .........................................tyg---MEMDVMTERSSKMSNLAYFVTKTGEKHLWSKMQCNVPIELKWSIPYGVA..QKKLWLKIRLVNYDNSADLQVAIRNPKADVAKCRKHIEEET..R.TPPEAF....FYIANSGQRWQa..qlNGSHGGYTLSTI..INPGTFSISFDLIFMCQKMCMGIEDKRKAACLVAFLEDELKNEIHHAVIDQVYVVGYPRRDCNNFREK-----llgf.
#=GC SS_cons                         ............................................--EEEEEE-HHHHTT-SSEEEEE-TT--EEEEE-TT--EEEEEEEE--TTTT..T---EEEEEEEEE-SSS-HHHHTT-TT-B----HHHHHT--..S.SSTT-S....EEEES-SSEEE.....EE-TTSSEEEEE..--TT--EEEEEEEESS-GGGS-HHHHTSEEEEEEEEE-TTS-EEEEEEEEEEEE-S-HHHHHHHHHHHHHH--.....
#=GC seq_cons                        .............................................caMch-Vhc-RuSKhSDhAatssssscKaLWoKMpCpVPItVKWplsSs+h..pKpLaL+lRLVNYpsspslEsAIRsPpoDVtKC+cHhpcEp..+.sP.ESF....FYIlNSupcWss....hsupKGpsFssh..lsPGTsplsFDLIFMCQ+pCMslEDKRKsMCLAVFLEDENGNEIhHuVIcQVhIVGYPRRDaKNFCEK.t...h....
//