GenomeNet

Database: Pfam
Entry: CHASE8
LinkDB: CHASE8
Original site: CHASE8 
#=GF ID   CHASE8
#=GF AC   PF17152.4
#=GF DE   Periplasmic sensor domain
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   Phmmer:P46139
#=GF GA   27.00 27.00;
#=GF TC   27.20 27.00;
#=GF NC   26.90 26.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   19543378
#=GF RT   Connecting quorum sensing, c-di-GMP, pel polysaccharide, and
#=GF RT   biofilm formation in Pseudomonas aeruginosa through tyrosine
#=GF RT   phosphatase TpbA (PA3885).
#=GF RA   Ueda A, Wood TK;
#=GF RL   PLoS Pathog. 2009;5:e1000483.
#=GF RN   [2]
#=GF RM   26148715
#=GF RT   Systematic Nomenclature for GGDEF and EAL Domain-Containing
#=GF RT   Cyclic Di-GMP Turnover Proteins of Escherichia coli.
#=GF RA   Hengge R, Galperin MY, Ghigo JM, Gomelsky M, Green J, Hughes KT,
#=GF RA   Jenal U, Landini P;
#=GF RL   J Bacteriol. 2015;198:7-11.
#=GF RN   [3]
#=GF RM   21181144
#=GF RT   GGDEF proteins YeaI, YedQ, and YfiN reduce early biofilm
#=GF RT   formation and swimming motility in Escherichia coli.
#=GF RA   Sanchez-Torres V, Hu H, Wood TK;
#=GF RL   Appl Microbiol Biotechnol. 2011;90:651-658.
#=GF RN   [4]
#=GF RM   21552365
#=GF RT   Tyrosine Phosphatase TpbA of Pseudomonas aeruginosa Controls
#=GF RT   Extracellular DNA via Cyclic Diguanylic Acid Concentrations.
#=GF RA   Ueda A, Wood TK;
#=GF RL   Environ Microbiol. 2010;2:449-455.
#=GF DR   INTERPRO; IPR033417;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   CHASE8 is a conserved periplasmic sensor domain found in
#=GF CC   histidine kinases, diguanylate cyclases/phosphodiesterases and
#=GF CC   methyl-accepting chemotaxis proteins, including the diguanylate
#=GF CC   cyclase DgcN (YfiN) that regulates biofilm formation and
#=GF CC   motility in Escherichia coli [1, 2]. In Pseudomonas aeruginosa,
#=GF CC   CHASE8 is the sensor domain in the diguanylate cyclase TpbB that
#=GF CC   regulates biofilm formation [3] by controlling the levels of
#=GF CC   extracellular DNA [4].
#=GF SQ   842
#=GS A0A1S9AAJ4_9BURK/38-142   AC A0A1S9AAJ4.1
#=GS A0A1M6Y597_9BURK/43-145   AC A0A1M6Y597.1
#=GS A0A261GFQ3_9GAMM/39-142   AC A0A261GFQ3.1
#=GS Q1IT59_KORVE/38-146       AC Q1IT59.1
#=GS A0A099PEF8_9GAMM/41-141   AC A0A099PEF8.1
#=GS A0A2A4G0C3_9SPHN/38-139   AC A0A2A4G0C3.1
#=GS A0A2A2RAU5_9BACT/87-189   AC A0A2A2RAU5.1
#=GS A0A245ZDL3_9SPHN/47-145   AC A0A245ZDL3.1
#=GS A0A098U563_9BURK/44-148   AC A0A098U563.1
#=GS Q8XRL8_RALSO/43-149       AC Q8XRL8.1
#=GS A0A139SJ52_9GAMM/46-139   AC A0A139SJ52.1
#=GS A0A1W1H5X2_9DELT/42-111   AC A0A1W1H5X2.1
#=GS Q12RH2_SHEDO/48-151       AC Q12RH2.1
#=GS W4M6D9_9BACT/24-139       AC W4M6D9.1
#=GS J0KH24_9BURK/50-157       AC J0KH24.1
#=GS A0A0S3EUP5_9SPHN/43-143   AC A0A0S3EUP5.1
#=GS E8MAJ7_9VIBR/40-149       AC E8MAJ7.1
#=GS A0A063Y418_9GAMM/49-148   AC A0A063Y418.1
#=GS M5DZ43_9GAMM/8-111        AC M5DZ43.1
#=GS A0A1M7H9S0_9BURK/46-156   AC A0A1M7H9S0.1
#=GS A0A077FKL4_9PSED/44-145   AC A0A077FKL4.1
#=GS A0A0G4JXZ6_9GAMM/48-149   AC A0A0G4JXZ6.1
#=GS A0A0A7PC36_9SPHN/50-147   AC A0A0A7PC36.1
#=GS B4EGX2_BURCJ/49-150       AC B4EGX2.1
#=GS A0A0D2UNZ6_9PROT/42-175   AC A0A0D2UNZ6.1
#=GS G7F868_9GAMM/41-135       AC G7F868.1
#=GS N6XY79_9RHOO/35-138       AC N6XY79.1
#=GS A0A133XL05_9RHOO/49-154   AC A0A133XL05.1
#=GS A0A177NT26_9GAMM/41-143   AC A0A177NT26.1
#=GS A0A1W9JQ61_9PROT/44-151   AC A0A1W9JQ61.1
#=GS G8Q662_PSEFL/43-144       AC G8Q662.1
#=GS A0A0Q0HAW7_9GAMM/41-138   AC A0A0Q0HAW7.1
#=GS A0A1W9K1J9_9PROT/42-152   AC A0A1W9K1J9.1
#=GS B1ZVH0_OPITP/39-143       AC B1ZVH0.1
#=GS A0A1G1JIV8_9BACT/40-145   AC A0A1G1JIV8.1
#=GS A0A1L8CQA8_9PROT/40-147   AC A0A1L8CQA8.1
#=GS A5GE93_GEOUR/38-135       AC A5GE93.1
#=GS A0A1G7T010_9PROT/44-147   AC A0A1G7T010.1
#=GS K9DFJ9_9BURK/38-143       AC K9DFJ9.1
#=GS D8F0T4_9DELT/39-145       AC D8F0T4.1
#=GS C0QF75_DESAH/41-150       AC C0QF75.1
#=GS A0A172U9G9_9GAMM/42-152   AC A0A172U9G9.1
#=GS A0A1H7X240_STIAU/46-147   AC A0A1H7X240.1
#=GS A0A172U946_9GAMM/41-191   AC A0A172U946.1
#=GS A0A1N6MVS5_9GAMM/57-158   AC A0A1N6MVS5.1
#=GS B5JQ89_9BACT/52-156       AC B5JQ89.1
#=GS A0A2D0LHI4_9GAMM/45-146   AC A0A2D0LHI4.1
#=GS A0A011PNS6_9PROT/39-146   AC A0A011PNS6.1
#=GS A0A1I4UV07_9GAMM/55-169   AC A0A1I4UV07.1
#=GS A6EVW8_9ALTE/41-144       AC A6EVW8.1
#=GS A0A1S1XYY2_9GAMM/42-141   AC A0A1S1XYY2.1
#=GS A0A1M5LWG5_9BURK/44-150   AC A0A1M5LWG5.1
#=GS A0A0S2K9I1_9GAMM/39-145   AC A0A0S2K9I1.1
#=GS A0A0S9MYJ7_9BURK/51-156   AC A0A0S9MYJ7.1
#=GS A0A1V2YX41_9ENTR/44-145   AC A0A1V2YX41.1
#=GS A0A0V9JTE7_9ENTR/44-145   AC A0A0V9JTE7.1
#=GS A0A0Q7RZ45_9BURK/39-144   AC A0A0Q7RZ45.1
#=GS E8RDK6_DESPD/41-151       AC E8RDK6.1
#=GS A0A0A7JG41_9PSED/44-145   AC A0A0A7JG41.1
#=GS K4KK48_SIMAS/44-150       AC K4KK48.1
#=GS A0A1T2KZ80_9GAMM/40-143   AC A0A1T2KZ80.1
#=GS N9BY15_9GAMM/42-142       AC N9BY15.1
#=GS D3NYR0_AZOS1/70-172       AC D3NYR0.1
#=GS A0A1I6KAC0_9BURK/37-133   AC A0A1I6KAC0.1
#=GS A0A1I3J0E5_9GAMM/45-146   AC A0A1I3J0E5.1
#=GS E0TGV1_PARBH/47-148       AC E0TGV1.1
#=GS D5VM36_CAUST/43-145       AC D5VM36.1
#=GS U3BL64_VIBPR/40-145       AC U3BL64.1
#=GS A0A0J1DH89_9BURK/38-142   AC A0A0J1DH89.1
#=GS A0A1Q5U8F1_9GAMM/45-146   AC A0A1Q5U8F1.1
#=GS A0A2C6L9G0_9VIBR/32-143   AC A0A2C6L9G0.1
#=GS A0A1H8LJR6_9BURK/42-147   AC A0A1H8LJR6.1
#=GS A0A095BZS3_9SPHN/50-147   AC A0A095BZS3.1
#=GS A0A0T9LAC6_9GAMM/48-149   AC A0A0T9LAC6.1
#=GS A0A0F6A1G1_9GAMM/42-143   AC A0A0F6A1G1.1
#=GS A0A1G9CT98_9PROT/41-141   AC A0A1G9CT98.1
#=GS M1P6G2_DESSD/41-151       AC M1P6G2.1
#=GS F0KPJ0_ACICP/1-101        AC F0KPJ0.1
#=GS A0A0J1JLQ3_9GAMM/41-150   AC A0A0J1JLQ3.1
#=GS G9ZZL7_9PROT/43-144       AC G9ZZL7.1
#=GS A0A257FUD8_9BURK/48-159   AC A0A257FUD8.1
#=GS A0A1F2VD33_9BACT/43-147   AC A0A1F2VD33.1
#=GS Q7CG65_YERPE/47-148       AC Q7CG65.1
#=GS Q15WC9_PSEA6/42-146       AC Q15WC9.1
#=GS A3WQM5_9GAMM/37-149       AC A3WQM5.1
#=GS A0A1Y0FWL5_9GAMM/40-146   AC A0A1Y0FWL5.1
#=GS B7RXE0_9GAMM/43-147       AC B7RXE0.1
#=GS A0A1Q6DM57_9DELT/40-161   AC A0A1Q6DM57.1
#=GS A0A1I1P4N6_9PSED/48-147   AC A0A1I1P4N6.1
#=GS A0A1M5QAW3_9BURK/40-157   AC A0A1M5QAW3.1
#=GS A0A1V1PCM1_9DELT/40-144   AC A0A1V1PCM1.1
#=GS A1K864_AZOSB/47-131       AC A1K864.1
#=GS A8T4E1_9VIBR/43-143       AC A8T4E1.1
#=GS D3VJ33_XENNA/45-146       AC D3VJ33.1
#=GS A0A158IHQ8_9BURK/49-150   AC A0A158IHQ8.1
#=GS A9F7N6_SORC5/56-159       AC A9F7N6.1
#=GS A0A143PWR7_9BACT/37-140   AC A0A143PWR7.1
#=GS A0A0A8WVZ3_9DELT/47-152   AC A0A0A8WVZ3.1
#=GS A0A1I4TZE0_9PROT/44-146   AC A0A1I4TZE0.1
#=GS A0A1I4NC25_9GAMM/41-159   AC A0A1I4NC25.1
#=GS A0A0K1K302_9BURK/38-142   AC A0A0K1K302.1
#=GS A0A1T4VDZ5_9GAMM/42-143   AC A0A1T4VDZ5.1
#=GS A0A0K1JXL2_9BURK/41-154   AC A0A0K1JXL2.1
#=GS A0A178K2B2_9GAMM/40-156   AC A0A178K2B2.1
#=GS A0A255HE17_9BURK/40-159   AC A0A255HE17.1
#=GS A0A1I4Q2C4_9GAMM/47-148   AC A0A1I4Q2C4.1
#=GS S3JNY1_9ENTR/44-145       AC S3JNY1.1
#=GS F4GC68_ALIDK/38-139       AC F4GC68.1
#=GS A0A255HJZ6_9BURK/44-130   AC A0A255HJZ6.1
#=GS A0A2A2WB70_9PLAN/40-145   AC A0A2A2WB70.1
#=GS R9ARV8_9GAMM/41-141       AC R9ARV8.1
#=GS F9ZVZ9_METMM/38-130       AC F9ZVZ9.1
#=GS A0A090UWU5_9ENTR/44-145   AC A0A090UWU5.1
#=GS A0A0Q0XWG5_9PSED/44-145   AC A0A0Q0XWG5.1
#=GS A0A081K6H3_9GAMM/40-146   AC A0A081K6H3.1
#=GS A0A0G3BI09_9BURK/36-132   AC A0A0G3BI09.1
#=GS Q8X9D9_ECO57/45-146       AC Q8X9D9.1
#=GS Q46Z48_CUPNJ/47-148       AC Q46Z48.1
#=GS V9R567_9PSED/41-142       AC V9R567.1
#=GS A0A172UCL3_9GAMM/44-151   AC A0A172UCL3.1
#=GS W1S8Q0_9SPHN/47-148       AC W1S8Q0.1
#=GS A0A0Q8R552_9SPHN/43-145   AC A0A0Q8R552.1
#=GS I3I491_9GAMM/37-144       AC I3I491.1
#=GS U3TTF2_9ENTR/44-144       AC U3TTF2.1
#=GS A0A257CK57_9BURK/43-148   AC A0A257CK57.1
#=GS A1SRM4_PSYIN/43-149       AC A1SRM4.1
#=GS A0A250B029_9ENTR/47-148   AC A0A250B029.1
#=GS A0A0J8VBG2_9GAMM/42-147   AC A0A0J8VBG2.1
#=GS A0A1G5FLT7_9DELT/46-167   AC A0A1G5FLT7.1
#=GS B1Y5B2_LEPCP/71-178       AC B1Y5B2.1
#=GS A0A1N6GCX9_9GAMM/43-159   AC A0A1N6GCX9.1
#=GS A0A1H9ECI9_9GAMM/40-141   AC A0A1H9ECI9.1
#=GS B7RWU5_9GAMM/18-139       AC B7RWU5.1
#=GS W1DM27_KLEPN/44-145       AC W1DM27.1
#=GS A0A1H6G8U4_9SPHN/50-147   AC A0A1H6G8U4.1
#=GS A0A1Y0FXI5_9GAMM/40-145   AC A0A1Y0FXI5.1
#=GS A0A0S4KG22_9BURK/37-141   AC A0A0S4KG22.1
#=GS A0A167ICI7_9BURK/40-143   AC A0A167ICI7.1
#=GS A0A1H4CAX9_9DELT/41-150   AC A0A1H4CAX9.1
#=GS E8WI48_GEOS8/38-134       AC E8WI48.1
#=GS A0A1W6BAZ1_9GAMM/50-151   AC A0A1W6BAZ1.1
#=GS W7QWQ8_9ALTE/39-146       AC W7QWQ8.1
#=GS G8TDJ1_NIAKG/40-139       AC G8TDJ1.1
#=GS J3H960_9PSED/43-144       AC J3H960.1
#=GS W1I0Y1_KLEPN/44-145       AC W1I0Y1.1
#=GS C4SDD5_YERMO/18-119       AC C4SDD5.1
#=GS Q08V63_STIAD/44-163       AC Q08V63.1
#=GS A0A0Q7A2S2_9BURK/38-142   AC A0A0Q7A2S2.1
#=GS D3RN99_ALLVD/42-163       AC D3RN99.1
#=GS L8JQJ0_9BACT/39-143       AC L8JQJ0.1
#=GS A0A0Q5H5S2_9BURK/40-156   AC A0A0Q5H5S2.1
#=GS A0A1L6I936_9BURK/37-138   AC A0A1L6I936.1
#=GS B9TLI9_RICCO/39-115       AC B9TLI9.1
#=GS A0A1W9JST5_9PROT/41-143   AC A0A1W9JST5.1
#=GS A0A1Y6BAJ2_9PROT/37-137   AC A0A1Y6BAJ2.1
#=GS A0A1P8FFD5_9PROT/41-145   AC A0A1P8FFD5.1
#=GS I3CDF2_9GAMM/40-144       AC I3CDF2.1
#=GS A0A1S1Y5B1_9GAMM/41-189   AC A0A1S1Y5B1.1
#=GS A0A0P8D1A4_9ALTE/46-128   AC A0A0P8D1A4.1
#=GS A0A0Q6BSD0_9PROT/42-148   AC A0A0Q6BSD0.1
#=GS H8GN69_METAL/40-142       AC H8GN69.1
#=GS A0A1S1Y7Q8_9GAMM/44-149   AC A0A1S1Y7Q8.1
#=GS A0A1G8G8U7_9RHOO/37-148   AC A0A1G8G8U7.1
#=GS A0A0Q5HAP0_9BURK/43-151   AC A0A0Q5HAP0.1
#=GS A0A172U3H8_9GAMM/42-141   AC A0A172U3H8.1
#=GS A0A1Y1R207_9GAMM/24-130   AC A0A1Y1R207.1
#=GS G8QFT7_DECSP/42-142       AC G8QFT7.1
#=GS A0A1I4LCI5_9GAMM/46-151   AC A0A1I4LCI5.1
#=GS A0A126T6S0_9GAMM/41-143   AC A0A126T6S0.1
#=GS K9D8L6_9BURK/40-155       AC K9D8L6.1
#=GS A0A0C4Y985_9BURK/47-147   AC A0A0C4Y985.1
#=GS I9W635_9RALS/29-130       AC I9W635.1
#=GS A0A2G2DQN1_9DELT/43-156   AC A0A2G2DQN1.1
#=GS A0A1F5AL53_9BACT/44-148   AC A0A1F5AL53.1
#=GS A0A165JJ79_9BURK/53-144   AC A0A165JJ79.1
#=GS A0A172U682_9GAMM/41-143   AC A0A172U682.1
#=GS B3PKJ3_CELJU/42-131       AC B3PKJ3.1
#=GS A0A1E2ZIN4_9GAMM/40-144   AC A0A1E2ZIN4.1
#=GS A0A1I1UZ92_9BURK/37-140   AC A0A1I1UZ92.1
#=GS F9TBY2_9VIBR/40-149       AC F9TBY2.1
#=GS A6DMH6_9BACT/37-141       AC A6DMH6.1
#=GS A0A1U9NH72_9BACT/39-144   AC A0A1U9NH72.1
#=GS A0A0C2F328_9PSED/44-145   AC A0A0C2F328.1
#=GS H1XPB0_9BACT/36-141       AC H1XPB0.1
#=GS R4YJU5_OLEAN/40-143       AC R4YJU5.1
#=GS A0A1N7NLS9_9GAMM/41-164   AC A0A1N7NLS9.1
#=GS A0A1H8DHR7_9PROT/44-146   AC A0A1H8DHR7.1
#=GS C6CBF5_DICP7/51-152       AC C6CBF5.1
#=GS A0A1G6IZ36_9BURK/59-160   AC A0A1G6IZ36.1
#=GS A0A1S1Y7J5_9GAMM/42-152   AC A0A1S1Y7J5.1
#=GS A0A091BD93_9GAMM/40-143   AC A0A091BD93.1
#=GS Q39V26_GEOMG/40-144       AC Q39V26.1
#=GS A0A0H3KNB4_BURM1/49-150   AC A0A0H3KNB4.1
#=GS F9ZZB9_METMM/41-143       AC F9ZZB9.1
#=GS A0A172UE54_9GAMM/43-164   AC A0A172UE54.1
#=GS A0A2A5BQJ8_9GAMM/40-144   AC A0A2A5BQJ8.1
#=GS A0A1R4HGZ0_9GAMM/43-138   AC A0A1R4HGZ0.1
#=GS A0A143B5Q0_9DELT/41-158   AC A0A143B5Q0.1
#=GS A0A085UBK8_YERRU/14-115   AC A0A085UBK8.1
#=GS A0A0K1JUQ7_9BURK/42-153   AC A0A0K1JUQ7.1
#=GS A0A2A5DMG2_9BACT/40-134   AC A0A2A5DMG2.1
#=GS D7DM83_METV0/39-139       AC D7DM83.1
#=GS A0A1Y6EFE8_9GAMM/39-151   AC A0A1Y6EFE8.1
#=GS J2HPI2_9CAUL/44-147       AC J2HPI2.1
#=GS B1ZYC1_OPITP/38-142       AC B1ZYC1.1
#=GS A0A1E8CM91_9GAMM/36-143   AC A0A1E8CM91.1
#=GS A0A172U5G6_9GAMM/38-127   AC A0A172U5G6.1
#=GS A0A0B1XTU2_9RALS/43-149   AC A0A0B1XTU2.1
#=GS D4DXF2_SEROD/47-148       AC D4DXF2.1
#=GS A0A0Q4N9M8_9GAMM/42-145   AC A0A0Q4N9M8.1
#=GS A0A0U2MIN0_9BURK/70-171   AC A0A0U2MIN0.1
#=GS A0A1U9NES5_9GAMM/37-144   AC A0A1U9NES5.1
#=GS A0A0X1T5M6_PSEAA/44-145   AC A0A0X1T5M6.1
#=GS Q7ME90_VIBVY/39-142       AC Q7ME90.1
#=GS A0A1D9H0X4_9BURK/44-144   AC A0A1D9H0X4.1
#=GS A0A147G2M9_9GAMM/44-144   AC A0A147G2M9.1
#=GS A0A1H8AGW2_9PROT/49-150   AC A0A1H8AGW2.1
#=GS Q21DZ3_SACD2/40-132       AC Q21DZ3.1
#=GS A0A1X1E4D0_9GAMM/45-146   AC A0A1X1E4D0.1
#=GS A0A1P8FN64_9PROT/48-153   AC A0A1P8FN64.1
#=GS Q1H2G8_METFK/41-147       AC Q1H2G8.1
#=GS A0A1F4JMA6_9BURK/43-147   AC A0A1F4JMA6.1
#=GS A0A098LCK1_9BACT/42-149   AC A0A098LCK1.1
#=GS A0YB25_9GAMM/52-160       AC A0YB25.1
#=GS Q0K8R5_CUPNH/47-148       AC Q0K8R5.1
#=GS E1VJA3_9GAMM/38-160       AC E1VJA3.1
#=GS F9ZEB6_9PROT/43-145       AC F9ZEB6.1
#=GS Q4KIQ2_PSEF5/43-144       AC Q4KIQ2.1
#=GS Q88DZ8_PSEPK/44-145       AC Q88DZ8.1
#=GS E0TCA4_PARBH/44-149       AC E0TCA4.1
#=GS A0A090VF38_9FLAO/15-120   AC A0A090VF38.1
#=GS A0A2G3JDE5_9NEIS/43-149   AC A0A2G3JDE5.1
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