#=GF ID CLASP_N
#=GF AC PF12348.9
#=GF DE CLASP N terminal
#=GF AU Mistry J;0000-0003-2479-5322
#=GF AU Wood V;0000-0001-6330-7526
#=GF SE Manual
#=GF GA 27.00 27.00;
#=GF TC 27.00 27.00;
#=GF NC 26.90 26.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 16951255
#=GF RT S. pombe CLASP needs dynein, not EB1 or CLIP170, to induce
#=GF RT microtubule instability and slows polymerization rates at cell
#=GF RT tips in a dynein-dependent manner.
#=GF RA Grallert A, Beuter C, Craven RA, Bagley S, Wilks D, Fleig U,
#=GF RA Hagan IM;
#=GF RL Genes Dev. 2006;20:2421-2436.
#=GF RN [2]
#=GF RM 16914514
#=GF RT Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity
#=GF RT by regulating spindle and kinetochore function.
#=GF RA Pereira AL, Pereira AJ, Maia AR, Drabek K, Sayas CL, Hergert PJ,
#=GF RA Lince-Faria M, Matos I, Duque C, Stepanova T, Rieder CL,
#=GF RA Earnshaw WC, Galjart N, Maiato H;
#=GF RL Mol Biol Cell. 2006;17:4526-4542.
#=GF DR INTERPRO; IPR024395;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This region is found at the N terminal of CLIP-associated
#=GF CC proteins (CLASPs). CLASPs are widely conserved microtubule
#=GF CC plus-end-tracking proteins that regulate the stability of
#=GF CC dynamic microtubules [1][2]. In yeast, Drosophila, and Xenopus,
#=GF CC a single CLASP orthologue is present. In mammals, a second
#=GF CC paralogue (CLASP2) exists which has some functional overlap with
#=GF CC CLASP1 [2].
#=GF SQ 7469
#=GS A0A2I0MNE2_COLLI/1206-1406 AC A0A2I0MNE2.1
#=GS A0A3Q1FL67_9TELE/75-218 AC A0A3Q1FL67.1
#=GS Q5KE09_CRYNJ/346-504 AC Q5KE09.2
#=GS A0A1W4VRU7_DROFC/854-1074 AC A0A1W4VRU7.1
#=GS A0A2J7R1V0_9NEOP/90-304 AC A0A2J7R1V0.1
#=GS A0A498JQB8_MALDO/782-1002 AC A0A498JQB8.1
#=GS A0A2H3E638_ARMGA/890-1077 AC A0A2H3E638.1
#=GS A0A0L0HR38_SPIPD/953-1157 AC A0A0L0HR38.1
#=GS A0A166U936_9HYPO/290-516 AC A0A166U936.1
#=GS A0A2H3E809_ARMGA/369-598 AC A0A2H3E809.1
#=GS A0A2A9NTK1_9AGAR/376-605 AC A0A2A9NTK1.1
#=GS A0A2U4CA49_TURTR/94-311 AC A0A2U4CA49.1
#=GS A0A3N4IRH2_ASCIM/252-478 AC A0A3N4IRH2.1
#=GS A0A3P9NSK4_POERE/42-213 AC A0A3P9NSK4.1
#=GS A0A2Y9KVF1_ENHLU/52-215 AC A0A2Y9KVF1.1
#=GS A0A455AET6_PHYMC/321-538 AC A0A455AET6.1
#=GS D8LJI4_ECTSI/27-236 AC D8LJI4.1
#=GS A0A3Q7XWW6_URSAR/856-1075 AC A0A3Q7XWW6.1
#=GS A0A3Q2DVS4_CYPVA/317-534 AC A0A3Q2DVS4.1
#=GS A0A2K6R9C8_RHIRO/327-544 AC A0A2K6R9C8.1
#=GS A0A2K5JR30_COLAP/211-420 AC A0A2K5JR30.1
#=GS A0A2I3N8A6_PAPAN/300-519 AC A0A2I3N8A6.1
#=GS A0A1Z5RQJ4_SORBI/188-406 AC A0A1Z5RQJ4.1
#=GS A0A1I8NBI5_MUSDO/275-475 AC A0A1I8NBI5.1
#=GS A0A2I2YAZ1_GORGO/322-539 AC A0A2I2YAZ1.1
#=GS A0A0G4IWU6_PLABS/62-243 AC A0A0G4IWU6.1
#=GS A0A1B7MMS8_9AGAM/2-142 AC A0A1B7MMS8.1
#=GS A0A074VNH7_9PEZI/1-215 AC A0A074VNH7.1
#=GS A0A484B6F8_DRONA/314-534 AC A0A484B6F8.1
#=GS J4VWJ3_BEAB2/283-490 AC J4VWJ3.1
#=GS A0A2A3EL92_APICC/473-685 AC A0A2A3EL92.1
#=GS A0A087WQ31_MOUSE/320-537 AC A0A087WQ31.1
#=GS A0A2Y9FK20_PHYMC/321-538 AC A0A2Y9FK20.1
#=GS A0A1Y1X413_9FUNG/8-224 AC A0A1Y1X413.1
#=GS A0A3L8Q775_CHLGU/10-84 AC A0A3L8Q775.1
#=GS A0A067K7L4_JATCU/86-274 AC A0A067K7L4.1
#=GS A0A267EM40_9PLAT/73-288 AC A0A267EM40.1
#=GS B5MCN5_HUMAN/1-145 AC B5MCN5.1
#=GS A0A2Y9LWD2_DELLE/88-305 AC A0A2Y9LWD2.1
#=GS A0A0E0PBC4_ORYRU/285-503 AC A0A0E0PBC4.1
#=GS A0A2K6FZH5_PROCO/47-216 AC A0A2K6FZH5.1
#=GS A0A452I0K4_9SAUR/320-537 AC A0A452I0K4.1
#=GS H0VSS1_CAVPO/94-244 AC H0VSS1.2
#=GS A0A2K6V620_SAIBB/297-514 AC A0A2K6V620.1
#=GS A0A2H3DBZ5_ARMGA/12-233 AC A0A2H3DBZ5.1
#=GS A0A1D6E6F7_MAIZE/315-534 AC A0A1D6E6F7.1
#=GS A0A3B4GJ77_9CICH/30-217 AC A0A3B4GJ77.1
#=GS A0A452CNU2_BALAS/329-546 AC A0A452CNU2.1
#=GS H2P7B6_PONAB/320-537 AC H2P7B6.1
#=GS A0A2Z6QQU4_9GLOM/1-223 AC A0A2Z6QQU4.1
#=GS A0A0V0VXY4_9BILA/55-220 AC A0A0V0VXY4.1
#=GS A0A3Q7U2S1_VULVU/321-538 AC A0A3Q7U2S1.1
#=GS A0A2I2Y7V1_GORGO/88-305 AC A0A2I2Y7V1.1
#=GS A0A2Y9LWC7_DELLE/321-538 AC A0A2Y9LWC7.1
#=GS J9JW89_ACYPI/854-1054 AC J9JW89.2
#=GS A0A1S3NZR3_SALSA/48-216 AC A0A1S3NZR3.1
#=GS S4RNG2_PETMA/258-475 AC S4RNG2.1
#=GS F6UN40_CALJA/47-216 AC F6UN40.2
#=GS A0A2U3ZJZ5_ODORO/89-306 AC A0A2U3ZJZ5.1
#=GS A0A2Y9FJG9_PHYMC/275-484 AC A0A2Y9FJG9.1
#=GS A0A0K9RTP7_SPIOL/393-613 AC A0A0K9RTP7.1
#=GS A0A0G4L749_9PEZI/6-219 AC A0A0G4L749.1
#=GS K9F9I2_PEND2/1-216 AC K9F9I2.1
#=GS A0A3M0L122_HIRRU/49-216 AC A0A3M0L122.1
#=GS A0A074RUJ3_9AGAM/367-596 AC A0A074RUJ3.1
#=GS K3W4R5_MOUSE/856-1075 AC K3W4R5.1
#=GS F6W5T2_MONDO/1231-1425 AC F6W5T2.1
#=GS A0A1D6N8P1_MAIZE/291-497 AC A0A1D6N8P1.1
#=GS A0A0V0SF51_9BILA/346-577 AC A0A0V0SF51.1
#=GS M2SIU8_COCSN/298-521 AC M2SIU8.1
#=GS A0A168KX73_MUCCL/892-1092 AC A0A168KX73.1
#=GS I1N9Y3_SOYBN/283-501 AC I1N9Y3.1
#=GS A0A3Q0GP12_ALLSI/1-117 AC A0A3Q0GP12.1
#=GS A0A2S4VDV2_9BASI/559-642 AC A0A2S4VDV2.1
#=GS A0A2K6ECT2_MACNE/1231-1425 AC A0A2K6ECT2.1
#=GS A0A445F6X2_GLYSO/290-496 AC A0A445F6X2.1
#=GS A0A2V1CK38_9HELO/283-509 AC A0A2V1CK38.1
#=GS A0A2G3BL45_CAPCH/637-837 AC A0A2G3BL45.1
#=GS A0A3Q7VY75_URSAR/320-537 AC A0A3Q7VY75.1
#=GS A0A3B3TGV4_9TELE/317-534 AC A0A3B3TGV4.1
#=GS A0A2I4B8F9_9TELE/325-542 AC A0A2I4B8F9.1
#=GS A0A1S3Q0N5_SALSA/318-535 AC A0A1S3Q0N5.1
#=GS A0A452I0D8_9SAUR/320-537 AC A0A452I0D8.1
#=GS A0A1S3Q0W0_SALSA/75-218 AC A0A1S3Q0W0.1
#=GS A0A1D1UF54_RAMVA/78-296 AC A0A1D1UF54.1
#=GS A0A1I8P7C8_STOCA/864-1081 AC A0A1I8P7C8.1
#=GS H3C516_TETNG/92-309 AC H3C516.1
#=GS U4UBM7_DENPD/190-408 AC U4UBM7.1
#=GS A0A0Q9X1B7_DROMO/854-1076 AC A0A0Q9X1B7.1
#=GS A0A088A8Y4_APIME/830-1068 AC A0A088A8Y4.1
#=GS A0A3Q0SS83_AMPCI/1156-1355 AC A0A3Q0SS83.1
#=GS A0A3B6PTI5_WHEAT/111-330 AC A0A3B6PTI5.1
#=GS A0A2H3ZPA4_PHODC/796-1016 AC A0A2H3ZPA4.1
#=GS A0A443SDG1_9ACAR/1-140 AC A0A443SDG1.1
#=GS F4Q7M6_CAVFA/774-982 AC F4Q7M6.1
#=GS A0A2K5Z0U5_MANLE/1231-1425 AC A0A2K5Z0U5.1
#=GS A0A194VYP0_9PEZI/6-219 AC A0A194VYP0.1
#=GS F6HZV1_VITVI/605-823 AC F6HZV1.1
#=GS A0A1S3MQZ4_SALSA/319-536 AC A0A1S3MQZ4.1
#=GS A0A2K6N558_RHIBE/98-314 AC A0A2K6N558.1
#=GS L1IE51_GUITC/174-399 AC L1IE51.1
#=GS A0A3B5R1W8_XIPMA/40-216 AC A0A3B5R1W8.1
#=GS A0A445LE02_GLYSO/787-1008 AC A0A445LE02.1
#=GS S2JRN0_MUCC1/277-465 AC S2JRN0.1
#=GS A0A0E0DFX9_9ORYZ/301-519 AC A0A0E0DFX9.1
#=GS A0A1Y2BWD4_9FUNG/303-473 AC A0A1Y2BWD4.1
#=GS B4QXQ9_DROSI/274-487 AC B4QXQ9.1
#=GS A0A2I3H4Q8_NOMLE/52-215 AC A0A2I3H4Q8.1
#=GS A0A2I4B0B9_9TELE/74-218 AC A0A2I4B0B9.1
#=GS H3A875_LATCH/90-307 AC H3A875.1
#=GS A0A1Y2F798_9BASI/1336-1510 AC A0A1Y2F798.1
#=GS A0A439D7N6_9PEZI/6-196 AC A0A439D7N6.1
#=GS A0A2K5E358_AOTNA/794-1013 AC A0A2K5E358.1
#=GS A0A1S3PNA0_SALSA/320-537 AC A0A1S3PNA0.1
#=GS A0A452SSL3_URSAM/11-141 AC A0A452SSL3.1
#=GS A0A2K5VI88_MACFA/320-537 AC A0A2K5VI88.1
#=GS A0A2H3IPR8_9EURO/323-549 AC A0A2H3IPR8.1
#=GS G5ATC5_HETGA/275-484 AC G5ATC5.1
#=GS A0A2K1QP31_9PEZI/283-509 AC A0A2K1QP31.1
#=GS H2L708_ORYLA/47-216 AC H2L708.2
#=GS A0A1S3AL64_ERIEU/53-216 AC A0A1S3AL64.1
#=GS A0A2H3ZG16_PHODC/771-991 AC A0A2H3ZG16.1
#=GS A0A2I2Z4N5_GORGO/98-315 AC A0A2I2Z4N5.1
#=GS A0A072VLE8_MEDTR/792-1012 AC A0A072VLE8.1
#=GS A0A3Q1GUU1_9TELE/318-535 AC A0A3Q1GUU1.1
#=GS A0A1D6E6E1_MAIZE/623-841 AC A0A1D6E6E1.1
#=GS G3VT83_SARHA/1321-1524 AC G3VT83.1
#=GS A0A2Y9IMG3_ENHLU/492-702 AC A0A2Y9IMG3.1
#=GS D3BUD1_POLPP/53-275 AC D3BUD1.1
#=GS A0A0V1L7S0_9BILA/47-280 AC A0A0V1L7S0.1
#=GS A0A2S4L1B1_9HYPO/7-227 AC A0A2S4L1B1.1
#=GS A0A2D0R4G0_ICTPU/578-766 AC A0A2D0R4G0.1
#=GS A0A0S7E824_9EURO/428-654 AC A0A0S7E824.1
#=GS A0A1S3AX30_CUCME/87-281 AC A0A1S3AX30.1
#=GS A0A3M7TBG6_BRAPC/10-197 AC A0A3M7TBG6.1
#=GS V7AZ30_PHAVU/96-299 AC V7AZ30.1
#=GS A0A3Q1HL03_9TELE/206-417 AC A0A3Q1HL03.1
#=GS A0A3Q3RY72_9TELE/285-502 AC A0A3Q3RY72.1
#=GS A0A2J6LWY1_LACSA/291-497 AC A0A2J6LWY1.1
#=GS A0A1B7MNB4_9AGAM/1-141 AC A0A1B7MNB4.1
#=GS A0A124SID2_CYNCS/414-633 AC A0A124SID2.1
#=GS I1C8N7_RHIO9/288-481 AC I1C8N7.1
#=GS A0A059B4I0_EUCGR/95-273 AC A0A059B4I0.1
#=GS A0A2K6ECT0_MACNE/856-1075 AC A0A2K6ECT0.1
#=GS U9SUT7_RHIID/1-223 AC U9SUT7.1
#=GS A0A3Q7SG59_VULVU/275-484 AC A0A3Q7SG59.1
#=GS A0A2I4B8I1_9TELE/325-542 AC A0A2I4B8I1.1
#=GS A0A195BPY8_9HYME/55-210 AC A0A195BPY8.1
#=GS A0A1S4EMF3_DIACI/56-188 AC A0A1S4EMF3.1
#=GS A0A0R3RZL0_9BILA/17-206 AC A0A0R3RZL0.2
#=GS A0A2P5E494_PARAD/97-283 AC A0A2P5E494.1
#=GS A0A2U4CA57_TURTR/94-311 AC A0A2U4CA57.1
#=GS A0A0D3F7N3_9ORYZ/58-167 AC A0A0D3F7N3.1
#=GS A0A1S4CQ38_TOBAC/307-525 AC A0A1S4CQ38.1
#=GS A0A0C3MEM4_9AGAM/1-161 AC A0A0C3MEM4.1
#=GS A0A2S6BQR9_9PEZI/1-218 AC A0A2S6BQR9.1
#=GS A0A2P6NDP9_9MYCE/269-468 AC A0A2P6NDP9.1
#=GS A0A0D2SBJ2_GOSRA/99-284 AC A0A0D2SBJ2.1
#=GS A0A059AHK2_EUCGR/118-322 AC A0A059AHK2.1
#=GS A0A090MY49_STRRB/109-314 AC A0A090MY49.1
#=GS A0A3Q7WDH7_URSAR/322-539 AC A0A3Q7WDH7.1
#=GS A7UUS1_ANOGA/736-950 AC A7UUS1.1
#=GS W5M252_LEPOC/321-538 AC W5M252.1
#=GS A0A2G8LR72_STIJA/1006-1219 AC A0A2G8LR72.1
#=GS A0A1V6TBR5_9EURO/317-543 AC A0A1V6TBR5.1
#=GS A0A2Y9KSY0_ENHLU/52-215 AC A0A2Y9KSY0.1
#=GS A0A3B4U7V4_SERDU/995-1189 AC A0A3B4U7V4.1
#=GS A0A2K5JF52_COLAP/323-540 AC A0A2K5JF52.1
#=GS A0A060WZH3_ONCMY/77-268 AC A0A060WZH3.1
#=GS A0A2K6P8J4_RHIRO/94-311 AC A0A2K6P8J4.1
#=GS A0A1V4K5U0_PATFA/48-216 AC A0A1V4K5U0.1
#=GS A0A2D0PVJ7_ICTPU/107-324 AC A0A2D0PVJ7.1
#=GS A0A453FSV8_AEGTS/291-497 AC A0A453FSV8.1
#=GS A0A3Q7TX03_VULVU/1231-1425 AC A0A3Q7TX03.1
#=GS A0A3M0JWF9_HIRRU/115-250 AC A0A3M0JWF9.1
#=GS A0A162MVB7_CORDF/330-529 AC A0A162MVB7.1
#=GS A0A2Y9JKJ5_ENHLU/47-216 AC A0A2Y9JKJ5.1
#=GS STU1_COCIM/1-216 AC Q1DS65.2
#=GS A0A1U8BZM0_MESAU/47-216 AC A0A1U8BZM0.1
#=GS A0A158R7Y1_TAEAS/604-770 AC A0A158R7Y1.1
#=GS A0A287AEM4_PIG/43-215 AC A0A287AEM4.1
#=GS A0A2D0PY36_ICTPU/70-218 AC A0A2D0PY36.1
#=GS A0A2K5JR37_COLAP/1167-1361 AC A0A2K5JR37.1
#=GS A0A3Q1MHN2_BOVIN/1354-1559 AC A0A3Q1MHN2.1
#=GS A0A3P8QVH6_ASTCA/31-217 AC A0A3P8QVH6.1
#=GS CLAP2_DANRE/89-306 AC Q6NYW6.1
#=GS A0A077S4T4_WHEAT/291-497 AC A0A077S4T4.1
#=GS G7L959_MEDTR/296-498 AC G7L959.2
#=GS A0A091DFJ5_FUKDA/320-537 AC A0A091DFJ5.1
#=GS A0A2K6FZI4_PROCO/316-533 AC A0A2K6FZI4.1
#=GS A0A0V1PCM3_9BILA/115-320 AC A0A0V1PCM3.1
#=GS A0A3B1J7L3_ASTMX/44-214 AC A0A3B1J7L3.1
#=GS A0A0V1KPS1_9BILA/55-220 AC A0A0V1KPS1.1
#=GS A0A2T6ZX15_TUBBO/291-517 AC A0A2T6ZX15.1
#=GS H0XCH2_OTOGA/275-492 AC H0XCH2.1
#=GS A0A2U3XFN5_LEPWE/856-1075 AC A0A2U3XFN5.1
#=GS A0A2D0PY41_ICTPU/321-538 AC A0A2D0PY41.1
#=GS A0A1S3PNC6_SALSA/320-537 AC A0A1S3PNC6.1
#=GS A0A068TTL1_COFCA/292-496 AC A0A068TTL1.1
#=GS A0A1U8HR80_GOSHI/744-954 AC A0A1U8HR80.1
#=GS A0A093PZX9_9PASS/858-1075 AC A0A093PZX9.1
#=GS A0A2C5Y9Y4_9HYPO/275-501 AC A0A2C5Y9Y4.1
#=GS F1M949_RAT/896-1091 AC F1M949.3
#=GS A0A1S3MQY9_SALSA/49-217 AC A0A1S3MQY9.1
#=GS A0A2D0RVD0_ICTPU/81-298 AC A0A2D0RVD0.1
#=GS A0A1S3WTE1_ERIEU/53-216 AC A0A1S3WTE1.1
#=GS A0A1S3PH08_SALSA/1-159 AC A0A1S3PH08.1
#=GS A0A164QR09_9AGAM/907-1092 AC A0A164QR09.1
#=GS S0DR33_GIBF5/7-220 AC S0DR33.1
#=GS A0A316V506_9BASI/338-565 AC A0A316V506.1
#=GS A0A087WP42_MOUSE/320-537 AC A0A087WP42.2
#=GS A0A199W0P4_ANACO/759-981 AC A0A199W0P4.1
#=GS A0A2I4CNF7_9TELE/41-216 AC A0A2I4CNF7.1
#=GS A0A182GZY0_AEDAL/1249-1426 AC A0A182GZY0.1
#=GS A0A1D6G9C7_MAIZE/291-497 AC A0A1D6G9C7.1
#=GS A0A287LVT9_HORVV/291-497 AC A0A287LVT9.1
#=GS A0A2P6PUL5_ROSCH/279-497 AC A0A2P6PUL5.1
#=GS A0A2K6AK38_MANLE/303-520 AC A0A2K6AK38.1
#=GS A0A2Y9KVF5_ENHLU/52-215 AC A0A2Y9KVF5.1
#=GS A0A0C3AY80_9AGAM/12-234 AC A0A0C3AY80.1
#=GS G1NH95_MELGA/48-216 AC G1NH95.2
#=GS A0A0F0IGF3_ASPPU/82-297 AC A0A0F0IGF3.1
#=GS A0A2K6ECT4_MACNE/856-1075 AC A0A2K6ECT4.1
#=GS A0A3M2RY03_9HYPO/33-246 AC A0A3M2RY03.1
#=GS I1NSP5_ORYGL/291-497 AC I1NSP5.1
#=GS A0A0N5E3X3_TRIMR/403-619 AC A0A0N5E3X3.1
#=GS A0A384AWC7_BALAS/329-546 AC A0A384AWC7.1
#=GS W4K4G0_9AGAM/1-169 AC W4K4G0.1
#=GS I1IBL5_BRADI/283-501 AC I1IBL5.1
#=GS A0A2Y9PKN7_DELLE/88-305 AC A0A2Y9PKN7.1
#=GS A0A2I4B889_9TELE/325-542 AC A0A2I4B889.1
#=GS Q5KG26_CRYNJ/18-241 AC Q5KG26.2
#=GS A0A0L0S7H9_ALLM3/9-225 AC A0A0L0S7H9.1
#=GS E7ERI8_HUMAN/321-538 AC E7ERI8.1
#=GS A0A2P7YW73_9PEZI/283-509 AC A0A2P7YW73.1
#=GS A0A0V1KPS1_9BILA/330-547 AC A0A0V1KPS1.1
#=GS A0A179FTL7_METCM/6-235 AC A0A179FTL7.1
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