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Database: Pfam
Entry: CLTH
LinkDB: CLTH
Original site: CLTH 
#=GF ID   CLTH
#=GF AC   PF10607.9
#=GF DE   CTLH/CRA C-terminal to LisH motif domain
#=GF PI   RanBPM_CRA;
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_3765 (release 22.0), UPF0559
#=GF GA   25.90 25.90;
#=GF TC   25.90 25.90;
#=GF NC   25.80 25.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   9817760
#=GF RT   When overexpressed, a novel centrosomal protein, RanBPM, causes
#=GF RT   ectopic microtubule nucleation similar to gamma-tubulin. 
#=GF RA   Nakamura M, Masuda H, Horii J, Kuma K, Yokoyama N, Ohba T,
#=GF RA   Nishitani H, Miyata T, Tanaka M, Nishimoto T; 
#=GF RL   J Cell Biol. 1998;143:1041-1052.
#=GF RN   [2]
#=GF RM   16478441
#=GF RT   RanBPM associates with CD39 and modulates ecto-nucleotidase
#=GF RT   activity. 
#=GF RA   Wu Y, Sun X, Kaczmarek E, Dwyer KM, Bianchi E, Usheva A, Robson
#=GF RA   SC; 
#=GF RL   Biochem J. 2006;396:23-30.
#=GF RN   [3]
#=GF RM   14722085
#=GF RT   RanBPM is a phosphoprotein that associates with the plasma
#=GF RT   membrane and interacts with the integrin LFA-1. 
#=GF RA   Denti S, Sirri A, Cheli A, Rogge L, Innamorati G, Putignano S,
#=GF RA   Fabbri M, Pardi R, Bianchi E; 
#=GF RL   J Biol Chem. 2004;279:13027-13034.
#=GF RN   [4]
#=GF RM   18040864
#=GF RT   RanBPM, a scaffolding protein in the immune and nervous systems. 
#=GF RA   Murrin LC, Talbot JN; 
#=GF RL   J Neuroimmune Pharmacol. 2007;2:290-295.
#=GF RN   [5]
#=GF RM   15381419
#=GF RT   The C terminus of fragile X mental retardation protein interacts
#=GF RT   with the multi-domain Ran-binding protein in the
#=GF RT   microtubule-organising centre. 
#=GF RA   Menon RP, Gibson TJ, Pastore A; 
#=GF RL   J Mol Biol. 2004;343:43-53.
#=GF RN   [6]
#=GF RM   11734546
#=GF RT   A new sequence motif linking lissencephaly, Treacher Collins and
#=GF RT   oral-facial-digital type 1 syndromes, microtubule dynamics and
#=GF RT   cell migration.
#=GF RA   Emes RD, Ponting CP;
#=GF RL   Hum Mol Genet. 2001;10:2813-2820.
#=GF DR   INTERPRO; IPR024964;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   RanBPM is a scaffolding protein and is important in regulating
#=GF CC   cellular function in both the immune system and the nervous
#=GF CC   system.  This domain is at the C-terminus of the proteins and is
#=GF CC   the binding domain for the CRA motif (for CT11-RanBPM), which is
#=GF CC   comprised of approximately 100 amino acids at the C terminal of
#=GF CC   RanBPM. It was found to be important for the interaction of
#=GF CC   RanBPM with fragile X mental retardation protein (FMRP), but its
#=GF CC   functional significance has yet to be determined [5]. This
#=GF CC   region contains CTLH and CRA domains annotated by SMART;
#=GF CC   however, these may be a single domain, and it is refereed to as
#=GF CC   a C-terminal to LisH motif [6].
#=GF SQ   5043
#=GS W9R6N0_9ROSA/60-202         AC W9R6N0.1
#=GS A0A022PS97_ERYGU/215-358    AC A0A022PS97.1
#=GS A0A0F8XAZ5_9EURO/164-309    AC A0A0F8XAZ5.1
#=GS A0A146FNI6_9EURO/106-259    AC A0A146FNI6.1
#=GS A0A1Y2FUM3_9ASCO/140-281    AC A0A1Y2FUM3.1
#=GS A0A1E4TEM4_9ASCO/262-447    AC A0A1E4TEM4.1
#=GS A0A0D2UN76_CAPO3/310-461    AC A0A0D2UN76.1
#=GS A0A017SDR5_9EURO/501-706    AC A0A017SDR5.1
#=GS A0A0V0V2C4_9BILA/263-572    AC A0A0V0V2C4.1
#=GS A0A197KGG6_9FUNG/556-768    AC A0A197KGG6.1
#=GS A0A0L0VEY6_9BASI/164-390    AC A0A0L0VEY6.1
#=GS C7Z8N8_NECH7/63-213         AC C7Z8N8.1
#=GS A0A225AUA3_9EURO/164-286    AC A0A225AUA3.1
#=GS A0A1X7QXZ1_9SACH/729-886    AC A0A1X7QXZ1.1
#=GS A0A1V8TKP4_9PEZI/472-704    AC A0A1V8TKP4.1
#=GS A0A2C9JVC9_BIOGL/104-245    AC A0A2C9JVC9.1
#=GS A0A0A1MHC7_9FUNG/15-173     AC A0A0A1MHC7.1
#=GS A0A1Y2BEL1_9FUNG/82-226     AC A0A1Y2BEL1.1
#=GS A0A183IP87_9BILA/151-293    AC A0A183IP87.1
#=GS A0A0A1NVU4_9FUNG/277-510    AC A0A0A1NVU4.1
#=GS Q0CWT9_ASPTN/478-683        AC Q0CWT9.1
#=GS A0A091IEM1_CALAN/159-339    AC A0A091IEM1.1
#=GS A5DNE9_PICGU/226-419        AC A5DNE9.2
#=GS A0A1J8QIW6_9HOMO/536-768    AC A0A1J8QIW6.1
#=GS A0A165QV22_9APHY/161-302    AC A0A165QV22.1
#=GS A0A1S3V5V7_VIGRR/632-774    AC A0A1S3V5V7.1
#=GS A0A0K9QT05_SPIOL/149-291    AC A0A0K9QT05.1
#=GS A0A091SHD5_9AVES/106-250    AC A0A091SHD5.1
#=GS A0A2C5Y648_9HYPO/163-306    AC A0A2C5Y648.1
#=GS A0A182EAM9_ONCOC/3-342      AC A0A182EAM9.1
#=GS A0A1W2TH60_ROSNE/163-312    AC A0A1W2TH60.1
#=GS V9E1F4_PHYPR/211-345        AC V9E1F4.1
#=GS A0A0G2E0S8_9PEZI/66-217     AC A0A0G2E0S8.1
#=GS A0A1C7NGI6_9FUNG/151-290    AC A0A1C7NGI6.1
#=GS A0A1E3PDG9_9ASCO/251-435    AC A0A1E3PDG9.1
#=GS A0DGB4_PARTE/62-200         AC A0DGB4.1
#=GS A0A091FSE7_9AVES/138-319    AC A0A091FSE7.1
#=GS A0A016SQN0_9BILA/315-620    AC A0A016SQN0.1
#=GS A0A0D2WQV5_CAPO3/179-320    AC A0A0D2WQV5.1
#=GS A0A183R1F3_9TREM/264-469    AC A0A183R1F3.1
#=GS F7CLX0_XENTR/64-208         AC F7CLX0.1
#=GS D7G2A7_ECTSI/60-204         AC D7G2A7.1
#=GS A0A080WLV5_TRIRC/63-213     AC A0A080WLV5.1
#=GS A0A0C9X0C0_9AGAR/60-205     AC A0A0C9X0C0.1
#=GS L8GWD1_ACACA/180-326        AC L8GWD1.1
#=GS M7XDX2_RHOT1/70-265         AC M7XDX2.1
#=GS A0A0V0QEA5_PSEPJ/19-150     AC A0A0V0QEA5.1
#=GS I1M875_SOYBN/53-197         AC I1M875.2
#=GS A0A0D2MPS8_9CHLO/65-209     AC A0A0D2MPS8.1
#=GS A0A2I4DRL8_9ROSI/77-221     AC A0A2I4DRL8.1
#=GS G4NIR9_MAGO7/120-268        AC G4NIR9.1
#=GS S3CBD4_OPHP1/526-727        AC S3CBD4.1
#=GS A0A0N5CK99_THECL/165-307    AC A0A0N5CK99.1
#=GS E7QEF9_YEASZ/765-926        AC E7QEF9.1
#=GS G1XUN7_ARTOA/161-302        AC G1XUN7.1
#=GS S2JAY6_MUCC1/416-626        AC S2JAY6.1
#=GS G3SZF8_LOXAF/314-625        AC G3SZF8.1
#=GS B4KN46_DROMO/634-927        AC B4KN46.2
#=GS D8LQC3_ECTSI/32-116         AC D8LQC3.1
#=GS A0A0G2EKV1_9EURO/131-286    AC A0A0G2EKV1.1
#=GS A0A0D0BR69_9AGAR/70-271     AC A0A0D0BR69.1
#=GS A0A093XEQ8_TALMA/164-309    AC A0A093XEQ8.1
#=GS A0A2H3E1U9_ARMGA/16-148     AC A0A2H3E1U9.1
#=GS A0A226F5I8_FOLCA/412-724    AC A0A226F5I8.1
#=GS W2K5I9_PHYPR/214-357        AC W2K5I9.1
#=GS F9X8A1_ZYMTI/342-552        AC F9X8A1.1
#=GS W4XUP8_STRPU/1-65           AC W4XUP8.1
#=GS A0A1S4CPJ8_TOBAC/35-179     AC A0A1S4CPJ8.1
#=GS M2SJY1_COCSN/162-337        AC M2SJY1.1
#=GS A0A158R5R7_9BILA/320-681    AC A0A158R5R7.1
#=GS A0A1J9PMB5_9EURO/619-881    AC A0A1J9PMB5.1
#=GS H2L3G6_ORYLA/159-301        AC H2L3G6.1
#=GS A0A1S3RV52_SALSA/159-301    AC A0A1S3RV52.1
#=GS F6ZQB2_CALJA/62-370         AC F6ZQB2.1
#=GS M4BBS9_HYAAE/528-735        AC M4BBS9.1
#=GS H3CRD6_TETNG/260-581        AC H3CRD6.1
#=GS F1R5A8_DANRE/152-294        AC F1R5A8.1
#=GS A0A0K9P1K1_ZOSMR/57-201     AC A0A0K9P1K1.1
#=GS A0A074XP50_AURPU/64-219     AC A0A074XP50.1
#=GS L8Y8N3_TUPCH/35-158         AC L8Y8N3.1
#=GS I2G4C6_USTH4/230-483        AC I2G4C6.1
#=GS A0A1S3LUQ8_SALSA/285-596    AC A0A1S3LUQ8.1
#=GS G8ZUA2_TORDC/667-825        AC G8ZUA2.1
#=GS A0A067MYQ4_9HOMO/816-1081   AC A0A067MYQ4.1
#=GS D5G8B2_TUBMM/169-320        AC D5G8B2.1
#=GS W7J7Q5_PLAFA/67-134         AC W7J7Q5.1
#=GS F6HW62_VITVI/160-302        AC F6HW62.1
#=GS A0A120E7L2_9BASI/170-325    AC A0A120E7L2.1
#=GS A0A2B7ZQT8_9EURO/63-214     AC A0A2B7ZQT8.1
#=GS A0A0C9T811_PLICR/159-300    AC A0A0C9T811.1
#=GS A0A0W0FZR8_9AGAR/160-302    AC A0A0W0FZR8.1
#=GS C7YIK3_NECH7/188-343        AC C7YIK3.1
#=GS A0A0L0S437_ALLMA/161-304    AC A0A0L0S437.1
#=GS L1IYH3_GUITH/52-214         AC L1IYH3.1
#=GS A0A093BUP7_TAUER/105-249    AC A0A093BUP7.1
#=GS A0A0L0VGV3_9BASI/77-232     AC A0A0L0VGV3.1
#=GS A0A0D1YUK3_9EURO/164-315    AC A0A0D1YUK3.1
#=GS A0A2B7XWI7_9EURO/167-320    AC A0A2B7XWI7.1
#=GS A0A183HZY6_9BILA/75-218     AC A0A183HZY6.1
#=GS A0A1D6A8F3_WHEAT/286-435    AC A0A1D6A8F3.1
#=GS F6XS96_XENTR/154-298        AC F6XS96.1
#=GS Q6BRY0_DEBHA/194-405        AC Q6BRY0.2
#=GS G0T006_RHOT2/456-640        AC G0T006.1
#=GS A0A1X2IR92_9FUNG/81-260     AC A0A1X2IR92.1
#=GS A0A0E0JPE6_ORYPU/53-189     AC A0A0E0JPE6.1
#=GS A7ESS6_SCLS1/73-143         AC A7ESS6.1
#=GS N1J6R4_BLUG1/70-221         AC N1J6R4.1
#=GS A0A2B7WY57_9EURO/63-214     AC A0A2B7WY57.1
#=GS A0A0L0SSA4_ALLMA/38-183     AC A0A0L0SSA4.1
#=GS M7TTR1_BOTF1/163-308        AC M7TTR1.1
#=GS A0A0D2NNS8_GOSRA/78-213     AC A0A0D2NNS8.1
#=GS H0X9X1_OTOGA/63-207         AC H0X9X1.1
#=GS A0A1G4JK47_9SACH/197-402    AC A0A1G4JK47.1
#=GS A0A287B9U8_PIG/108-252      AC A0A287B9U8.1
#=GS A0A024WKH6_PLAFA/67-212     AC A0A024WKH6.1
#=GS A0A0V0UIN9_9BILA/319-637    AC A0A0V0UIN9.1
#=GS A0A232F0Z1_9HYME/279-567    AC A0A232F0Z1.1
#=GS A0A2C5YA24_9HYPO/60-210     AC A0A2C5YA24.1
#=GS A0A093EPS4_TYTAL/106-250    AC A0A093EPS4.1
#=GS R7SNR7_DICSQ/159-300        AC R7SNR7.1
#=GS A0A0A0A6G0_CHAVO/215-523    AC A0A0A0A6G0.1
#=GS A0A091H1M2_BUCRH/136-316    AC A0A091H1M2.1
#=GS A0A151W6J0_HYPMA/105-312    AC A0A151W6J0.1
#=GS K4BFL0_SOLLC/312-459        AC K4BFL0.1
#=GS A0A1C7NLT1_9FUNG/372-565    AC A0A1C7NLT1.1
#=GS H0VJV5_CAVPO/250-557        AC H0VJV5.2
#=GS A0A0B0MI55_GOSAR/51-193     AC A0A0B0MI55.1
#=GS A0A182H9B8_AEDAL/161-306    AC A0A182H9B8.1
#=GS A0A2I4APG7_9TELE/111-253    AC A0A2I4APG7.1
#=GS A0A2A2J622_9BILA/275-421    AC A0A2A2J622.1
#=GS A0A0V1CLF6_TRIBR/52-193     AC A0A0V1CLF6.1
#=GS R0L9I2_ANAPL/63-207         AC R0L9I2.1
#=GS W5MXW9_LEPOC/197-341        AC W5MXW9.1
#=GS E9ETS3_METRA/163-309        AC E9ETS3.1
#=GS A0A226PFK6_COLVI/63-207     AC A0A226PFK6.1
#=GS A0A0D2KU07_9CHLO/9-134      AC A0A0D2KU07.1
#=GS D2VEK9_NAEGR/71-215         AC D2VEK9.1
#=GS E0VSI8_PEDHC/153-298        AC E0VSI8.1
#=GS I1CJP8_RHIO9/59-171         AC I1CJP8.1
#=GS A0A0D8XK82_DICVI/247-533    AC A0A0D8XK82.1
#=GS A0A0K9QHL0_SPIOL/186-328    AC A0A0K9QHL0.1
#=GS A0A2K5HEV4_COLAP/111-253    AC A0A2K5HEV4.1
#=GS V8NJT8_OPHHA/174-444        AC V8NJT8.1
#=GS A0A2G3D8G3_CAPCH/149-291    AC A0A2G3D8G3.1
#=GS A0A1U8K8B9_GOSHI/51-193     AC A0A1U8K8B9.1
#=GS A0A183KW60_9TREM/158-237    AC A0A183KW60.1
#=GS A0A0B7N8C9_9FUNG/417-642    AC A0A0B7N8C9.1
#=GS A0A2H2JAE8_CAEJA/40-142     AC A0A2H2JAE8.1
#=GS A0A1U7KXI5_9APHY/279-423    AC A0A1U7KXI5.1
#=GS A0A095CCP5_SCHHA/94-174     AC A0A095CCP5.1
#=GS A0A0D2GG24_9EURO/164-315    AC A0A0D2GG24.1
#=GS A0A0J8U2A3_COCIT/41-192     AC A0A0J8U2A3.1
#=GS A0A066XNW4_COLSU/63-214     AC A0A066XNW4.1
#=GS J4C8R5_THEOR/178-349        AC J4C8R5.1
#=GS F7W7R2_SORMK/72-220         AC F7W7R2.1
#=GS A0A1L0DN59_9ASCO/126-283    AC A0A1L0DN59.1
#=GS A0A1B0FK71_GLOMM/215-360    AC A0A1B0FK71.1
#=GS A0A0D2DE95_9EURO/57-227     AC A0A0D2DE95.1
#=GS A0A0S4T6Q4_HYMMI/168-312    AC A0A0S4T6Q4.1
#=GS A0A091MHN3_CARIC/175-483    AC A0A091MHN3.1
#=GS B6QGU0_TALMQ/164-309        AC B6QGU0.1
#=GS A0A165H8R4_9APHY/146-285    AC A0A165H8R4.1
#=GS A0A182P295_9DIPT/63-117     AC A0A182P295.1
#=GS A0A194V3K9_9PEZI/344-540    AC A0A194V3K9.1
#=GS A0A225X2F0_9STRA/87-231     AC A0A225X2F0.1
#=GS G0R0Q6_ICHMG/150-293        AC G0R0Q6.1
#=GS K7FK92_PELSI/163-447        AC K7FK92.1
#=GS A0A091W3E6_OPIHO/226-542    AC A0A091W3E6.1
#=GS A0A094LC95_9AVES/9-189      AC A0A094LC95.1
#=GS A0A093VBC8_TALMA/55-197     AC A0A093VBC8.1
#=GS A0A1V8U056_9PEZI/155-298    AC A0A1V8U056.1
#=GS F8QEL1_SERL3/69-276         AC F8QEL1.1
#=GS A0A1I8J7L4_9PLAT/264-447    AC A0A1I8J7L4.1
#=GS Q0CRE2_ASPTN/410-564        AC Q0CRE2.1
#=GS V7BQG8_PHAVU/77-221         AC V7BQG8.1
#=GS A0A1U7Q4T6_MESAU/159-219    AC A0A1U7Q4T6.1
#=GS G8YN14_PICSO/196-374        AC G8YN14.1
#=GS A0A0F9XSX5_TRIHA/62-210     AC A0A0F9XSX5.1
#=GS A0A1S8VW00_9FUNG/161-283    AC A0A1S8VW00.1
#=GS A0A1L8HKM3_XENLA/159-301    AC A0A1L8HKM3.1
#=GS A0A022RZZ8_ERYGU/149-291    AC A0A022RZZ8.1
#=GS A0A0D9ZUK0_9ORYZ/173-315    AC A0A0D9ZUK0.1
#=GS U6GUS5_EIMAC/284-409        AC U6GUS5.1
#=GS A0A2G8K5B2_STIJA/139-280    AC A0A2G8K5B2.1
#=GS A0A0E0PHV8_ORYRU/170-312    AC A0A0E0PHV8.1
#=GS A0A1Y2EB07_9PEZI/479-680    AC A0A1Y2EB07.1
#=GS B3SBV8_TRIAD/168-310        AC B3SBV8.1
#=GS M2WU54_GALSU/140-282        AC M2WU54.1
#=GS A0A0C3H668_9PEZI/163-317    AC A0A0C3H668.1
#=GS A0A182P3H3_9DIPT/158-300    AC A0A182P3H3.1
#=GS A0A2G9HGA4_9LAMI/149-291    AC A0A2G9HGA4.1
#=GS A0A093QTV8_PHACA/106-250    AC A0A093QTV8.1
#=GS E9DYW8_METAQ/163-309        AC E9DYW8.1
#=GS A0A1S2YSD7_CICAR/47-197     AC A0A1S2YSD7.1
#=GS A0A2G2ZM68_CAPAN/312-460    AC A0A2G2ZM68.1
#=GS A0A1M2VIP2_TRAPU/160-301    AC A0A1M2VIP2.1
#=GS A0A2H3ISS5_WOLCO/606-828    AC A0A2H3ISS5.1
#=GS A0A1C1C968_9EURO/57-227     AC A0A1C1C968.1
#=GS K1Q8U6_CRAGI/13-157         AC K1Q8U6.1
#=GS H1UXM9_COLHI/473-651        AC H1UXM9.1
#=GS B4L3B5_DROMO/63-205         AC B4L3B5.1
#=GS A0A284QQ99_9AGAR/130-271    AC A0A284QQ99.1
#=GS D5GAC8_TUBMM/161-303        AC D5GAC8.1
#=GS A0A1J9S1R9_9PEZI/165-308    AC A0A1J9S1R9.1
#=GS G3HK85_CRIGR/111-253        AC G3HK85.1
#=GS K7MNY2_SOYBN/53-197         AC K7MNY2.1
#=GS A0A1Y2DD82_9FUNG/328-505    AC A0A1Y2DD82.1
#=GS FYV10_ASPFU/164-314         AC Q4WTQ4.2
#=GS M3XG65_FELCA/155-299        AC M3XG65.1
#=GS Q28X32_DROPS/198-343        AC Q28X32.1
#=GS A0A0E0N372_ORYRU/54-197     AC A0A0E0N372.1
#=GS A0A0A2KD12_PENIT/68-217     AC A0A0A2KD12.1
#=GS A0A2G9HH59_9LAMI/143-283    AC A0A2G9HH59.1
#=GS I1I3M9_BRADI/76-219         AC I1I3M9.1
#=GS R4FQB3_RHOPR/152-298        AC R4FQB3.1
#=GS A0A0K0FVU1_9BILA/101-243    AC A0A0K0FVU1.1
#=GS I2G4F4_USTH4/59-214         AC I2G4F4.1
#=GS A0A287DG86_ICTTR/319-630    AC A0A287DG86.1
#=GS A0A091PUG7_LEPDC/9-189      AC A0A091PUG7.1
#=GS A0A094DCG6_9PEZI/45-194     AC A0A094DCG6.1
#=GS A0A1X2ICZ7_9FUNG/317-592    AC A0A1X2ICZ7.1
#=GS X0CZI2_FUSOX/184-339        AC X0CZI2.1
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