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Database: Pfam
Entry: CRA
LinkDB: CRA
Original site: CRA 
#=GF ID   CRA
#=GF AC   PF06589.13
#=GF DE   Circumsporozoite-related antigen (CRA)
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_19386 (release 10.0)
#=GF GA   43.10 43.10;
#=GF TC   45.80 43.60;
#=GF NC   41.00 40.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   8050527
#=GF RT   Plasmodium falciparum: exported protein-1, a blood stage
#=GF RT   antigen, is expressed in liver stage parasites. 
#=GF RA   Sanchez GI, Rogers WO, Mellouk S, Hoffman SL; 
#=GF RL   Exp Parasitol 1994;79:59-62.
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of several circumsporozoite-related antigen
#=GF CC   (CRA) or exported protein-1 (EXP1) sequences found specifically
#=GF CC   in Plasmodium species. The function of this family is unknown.
#=GF SQ   44
#=GS A0A0L1IAR5_PLAFA/2-132    AC A0A0L1IAR5.1
#=GS Q7R7H8_PLAYO/2-130        AC Q7R7H8.1
#=GS A0A1C3KCK0_PLAMA/33-106   AC A0A1C3KCK0.1
#=GS A0A1A8YK68_9APIC/2-154    AC A0A1A8YK68.1
#=GS A0A1J1H574_PLARL/17-104   AC A0A1J1H574.1
#=GS A0A0L7KLW0_PLAFX/18-108   AC A0A0L7KLW0.1
#=GS A0A509AQ14_PLABA/32-104   AC A0A509AQ14.1
#=GS A0A024W8Z7_PLAFA/2-132    AC A0A024W8Z7.1
#=GS A0A509B269_PLABA/80-170   AC A0A509B269.1
#=GS A0A1Y1JLQ1_PLAGO/39-106   AC A0A1Y1JLQ1.1
#=GS A0A1A8YUQ5_9APIC/33-105   AC A0A1A8YUQ5.1
#=GS A0A509AME9_PLABA/2-151    AC A0A509AME9.1
#=GS A0A1A8XGC4_9APIC/26-105   AC A0A1A8XGC4.1
#=GS A0A0L7M8Y9_PLAF4/2-132    AC A0A0L7M8Y9.1
#=GS A5K4M8_PLAVS/1-106        AC A5K4M8.1
#=GS A0A1Y1JD46_PLAGO/2-142    AC A0A1Y1JD46.1
#=GS Q8IBD0_PLAF7/2-132        AC Q8IBD0.1
#=GS W4IU23_PLAFP/18-108       AC W4IU23.1
#=GS A0A024X652_PLAFC/18-108   AC A0A024X652.1
#=GS A0A653H226_9APIC/2-138    AC A0A653H226.1
#=GS A0A0L7KLK4_PLAFX/2-132    AC A0A0L7KLK4.1
#=GS Q8IIF0_PLAF7/18-108       AC Q8IIF0.1
#=GS Q7RLY3_PLAYO/2-123        AC Q7RLY3.1
#=GS A0A1A8WRG8_9APIC/2-152    AC A0A1A8WRG8.1
#=GS K6UDF1_9APIC/1-106        AC K6UDF1.1
#=GS Q7RQT8_PLAYO/2-126        AC Q7RQT8.1
#=GS A0A024WQD4_PLAFA/18-108   AC A0A024WQD4.1
#=GS A0A024X986_PLAFC/2-132    AC A0A024X986.1
#=GS W7JDS7_PLAFA/2-132        AC W7JDS7.1
#=GS A0A024VS38_PLAFA/454-584  AC A0A024VS38.1
#=GS A0A1D3THZ1_9APIC/26-105   AC A0A1D3THZ1.1
#=GS A0A384LP13_PLAKH/38-106   AC A0A384LP13.1
#=GS W7JTD3_PLAFO/18-108       AC W7JTD3.1
#=GS A0A024W4Z2_PLAFA/18-108   AC A0A024W4Z2.1
#=GS A0A0L0CW34_PLAFA/2-132    AC A0A0L0CW34.1
#=GS K6V7K9_9APIC/17-157       AC K6V7K9.1
#=GS Q7RET0_PLAYO/2-151        AC Q7RET0.1
#=GS A5K5F2_PLAVS/2-143        AC A5K5F2.1
#=GS Q7RI01_PLAYO/2-148        AC Q7RI01.1
#=GS A0A1A8WKF7_PLAMA/2-144    AC A0A1A8WKF7.1
#=GS A0A679L6W5_PLAKH/2-150    AC A0A679L6W5.1
#=GS Q7RGC6_PLAYO/41-107       AC Q7RGC6.1
#=GS A0A1D3JCN4_9APIC/2-152    AC A0A1D3JCN4.1
#=GS W7JLS6_PLAFA/18-108       AC W7JLS6.1
A0A0L1IAR5_PLAFA/2-132               ...................KNKLSTLFFItIFLILI.FIDSAKGDE..R----KNFWKSRFT.....AG--.-R.G...NIT....N...K.PTEVNH..P.IK..KEGENFls.............vgK--GDHD...ES..R..VMLLKELYQKDNELNIVRKKHKKYKSITVALASIIGMMLLRNIGSLLYDTVTR-----lnqksn.................................................................................
Q7R7H8_PLAYO/2-130                   ...................NKKLYSLFFL.IYLIVL.YCATVQGNK..DDNGKNDRHGKNII.....KK--.-N.Y...NKN....N...K.QMKGTN..E.DH.tEDNEEF.................DENYEDN...KE..S..MRLINKKEKKESEANKLSKIKKAY---AFGITTVIALNILFLLKNYINNNLADPNGHI.......................................................................................
A0A1C3KCK0_PLAMA/33-106              ............pkkkspk----------.------.---------..--------------.....----.--.-...---....-...-.------..-.--..------.................-KTPDPL...ID..V..HEIINDMVKKEEEIVNLSKKKSAYKTATTALASTLGLVSALLLGGIGLVLYNNERGRH.......................................................................................
A0A1A8YK68_9APIC/2-154               ...................KNRLSSLFVI.SFFLLVvFSNVIKGDN..NINKKKDMWISRFF.....LGKR.DQ.K...TDNdvseE...E.HKAKIE..K.AK..IEKEKIekekke.....keeiltSNNKEDV...ND..VrsMLLLKEIYEKDNQLSIISRKKKKYKTATFTLGTLLTLIAVRALANLAVNGL-------tklvqre................................................................................
A0A1J1H574_PLARL/17-104              ...................----------.------.---------..--------------.....----.--.-...---....N...K.SIEGKV..T.SV..ENNKTI.................PKKKSKQkldID..V..SEILSDMIKKDEELVKVSKSRSKYKVITGALASTLAILAAAVASGVGLVLYNTSHNRH.......................................................................................
A0A0L7KLW0_PLAFX/18-108              keslaektnkgtgsgvssk----------.------.---------..--------------.....----.--.-...---....-...-.------..-.--..KKNK--.................KGSGEPL...ID..V..HDLISDMIKKEEELVEVNKRKSKYKLATSVLAGLLGVVSTVLLGGVGLVLYNTEKGRH.......................................................................................
A0A509AQ14_PLABA/32-104              ................skn----------.------.---------..--------------.....----.--.-...---....-...-.------..-.--..----VI.................KKPAEPV...ID..V..QELISDMVKKEEEIVKLAKNKKSLRKANVALATALSVVSALLLGGAGLVMYNTEKGRH.......................................................................................
A0A024W8Z7_PLAFA/2-132               ...................KNKLSTLFFItIFLILI.FIDSAKGDE..R----KNFWKSRFT.....AG--.-R.G...NIT....N...K.PTEVNH..P.IK..KEGENFls.............vgK--GDHD...ES..R..VMLLKELYQKDNELNIVRKKHKKYKSITVALASIIGMMLLRNIGSLLYDTVTR-----lnqksn.................................................................................
A0A509B269_PLABA/80-170              ...................NTKLYSLFVF.IYLIIV.YCATVHGNK..NDNGKNNGNGLSFI.....KKIYqND.N...NKD....N...K.HVQRTG..E.D-..------.................-------...--..-..----------------------------------------------------------gigtfdikylykcfcyvyiqviqncvntkvc........................................................
A0A1Y1JLQ1_PLAGO/39-106              ..................k----------.------.---------..--------------.....----.--.-...---....-...-.------..-.--..------.................-KAPEPL...ID..V..HELISEMVRKEEELVTVTKQKSKYKMVATVLASLLGIVSGVLAGGAGLVLHNTSKGR-p......................................................................................
A0A1A8YUQ5_9APIC/33-105              .............kkkvqk----------.------.---------..--------------.....----.--.-...---....-...-.------..-.--..------.................-RAPEPL...ID..V..HELIGDMVKKEEELVKLSKKKSTYKTATTILATALGVVSALLLGGTGLVLYNTERGRH.......................................................................................
A0A509AME9_PLABA/2-151               ...................KHKLHTFFVI.ICLVVVlYCGGIEGKQ..NNNIKKDMWISRFF.....THKN.GK.Y...ARN....E...K.TVENAE..G.GN..KNNEILddlynedidevvknilkSENVDIQ...T-..-..LKIIKELDKKKNEVIIANKQKNLYKSGAFGMSVIFLSFALRELAELLVNYYLDKHHNT.......................................................................................
A0A1A8XGC4_9APIC/26-105              .......gggnsgpkkkvq----------.------.---------..--------------.....----.--.-...---....-...-.------..-.--..------.................KRSPEPL...ID..V..HELIGDMVKKEEELVKLSKKKSTYKTATTILATALGVVSALLLGGTGLVLYNTERGRH.......................................................................................
A0A0L7M8Y9_PLAF4/2-132               ...................KNKLSTLFFItIFLILI.FIDSAKGDE..R----KNFWKSRFT.....AG--.-R.G...NIT....N...K.PTEVNH..P.IK..KEGENFls.............vgK--GDHD...ES..R..VMLLKELYQKDNELNIVRKKHKKYKSITVALASIIGMMLLRNIGSLLYDTVTR-----lnqksn.................................................................................
A5K4M8_PLAVS/1-106                   ..................m--KLLAAVFL.-LFCAI.LCNHALGDN..VN-GLGAGNPKKKS.....PK--.--.-...---....-...-.------..-.--..------.................SKSPEPL...ID..V..HELISEIVRKEEELVNMTKKKSNYKLATTVLASALGVVSAVLLGGAGLVFYNAGNGRH.......................................................................................
A0A1Y1JD46_PLAGO/2-142               ...................KSKLSILFVI.NLLLLItVSDVIKGDN..SINKNKDIWKSRFT.....VGK-.GT.P...KKN....E...D.ISEKNK..KkDN.kKEKDDIq..............tgINNRDDM...NDsrS..IMLLREIYEKDNQLSIVNRKKKKYKTATFTLGTLLTIIALRTIADIAVKGI-------sklfqke................................................................................
Q8IBD0_PLAF7/2-132                   ...................KNKLSTLFFItIFLILI.FIDSAKGDE..R----KNFWKSRFT.....AG--.-R.G...NIT....N...K.PTEVNH..P.IK..KEGENFls.............vgK--GDHD...ES..R..VMLLKELYQKDNELNIVRKKHKKYKSITVALASIIGMMLLRNIGSLLYDTVTR-----lnqksn.................................................................................
W4IU23_PLAFP/18-108                  keslaektnkgtgsgvssk----------.------.---------..--------------.....----.--.-...---....-...-.------..-.--..KKNK--.................KGSGEPL...ID..V..HDLISDMIKKEEELVEVNKRKSKYKLATSVLAGLLGVVSTVLLGGVGLVLYNTEKGRH.......................................................................................
A0A024X652_PLAFC/18-108              keslaektnkgtgsgvssk----------.------.---------..--------------.....----.--.-...---....-...-.------..-.--..KKNK--.................KGSGEPL...ID..V..HDLISDMIKKEEELVEVNKRKSKYKLATSVLAGLLGVVSTVLLGGVGLVLYNTEKGRH.......................................................................................
A0A653H226_9APIC/2-138               ..................a-NKLLSLFVI.TIFFLVnFSYVITGHK..NENSKNNMWISRFN.....MGKD.GNkI...NKD...aD...R.HLHETY..K.KD..TDNLLN.................SNKKDVF...TDerS..ALLLKEIYTKDKELSIIKRKKKMYKNATITLGTLIAVIAIRLIKKYIENYLL------klvd...................................................................................
A0A0L7KLK4_PLAFX/2-132               ...................KNKLSTLFFItIFLILI.FIDSAKGDE..R----KNFWKSRFT.....AG--.-R.G...NIT....N...K.PTEVNH..P.IK..KEGENFls.............vgK--GDHD...ES..R..VMLLKELYQKDNELNIVRKKHKKYKSITVALASIIGMMLLRNIGSLLYDTVTR-----lnqksn.................................................................................
Q8IIF0_PLAF7/18-108                  keslaektnkgtgsgvssk----------.------.---------..--------------.....----.--.-...---....-...-.------..-.--..KKNK--.................KGSGEPL...ID..V..HDLISDMIKKEEELVEVNKRKSKYKLATSVLAGLLGVVSTVLLGGVGLVLYNTEKGRH.......................................................................................
Q7RLY3_PLAYO/2-123                   ...................NTKLYSLFVF.ICLIIV.YCATVQGSK..-DNGKNGVYELKMI.....KKKH.KK.N...NKD....N...K.HVQRAG..E.--..------.................DEDEDDN...ID..Y..TNLVKEEEKRNEEVKRLSKMHKAY---TLGMSTIIFLSTLFLIRDCVLESISRPDSY-i......................................................................................
A0A1A8WRG8_9APIC/2-152               ...................KNKLSSLFVI.SFFLLVvFSNVIKGDN..NINKKRDMWISRFF.....LGKR.DQ.K...TDNdvseEehkA.KIEKAKieK.EK.kEKEEIL................tSNNKEDM...ND..VrsMLLLKEIYEKDNQLSIISRKKKKYKTATFTLGTLLTLIAVRALANLAVNGL-------tklvqkeena.............................................................................
K6UDF1_9APIC/1-106                   ..................m--KLLTAVFL.-LFCAI.LCDPALGDN..VN-GLGGPPSKKKT.....PK--.--.-...---....-...-.------..-.--..------.................SKSPEPL...ID..V..HELIGEMVRKEEELINANKKKSKYKLATTILASALGVVSAVLLGGAGLVFYNAGNGRH.......................................................................................
Q7RQT8_PLAYO/2-126                   ...................NTKLYSLFVF.IYLIVV.YCATVQGNK..--NGKNDVHEPNGI.....NK--.KS.N...KKD....N...K.HVQKTD..G.-I..EDYENF.................DKNCEPN...KE..S..MNSVKEED-IESEAIRASKKKEAY---IVGISSLATVLTLSMLRGCALAVVVNSN---syn....................................................................................
A0A024WQD4_PLAFA/18-108              keslaektnkgtgsgvssk----------.------.---------..--------------.....----.--.-...---....-...-.------..-.--..KKNK--.................KGSGEPL...ID..V..HDLISDMIKKEEELVEVNKRKSKYKLATSVLAGLLGVVSTVLLGGVGLVLYNTEKGRH.......................................................................................
A0A024X986_PLAFC/2-132               ...................KNKLSTLFFItIFLILI.FIDSAKGDE..R----KNFWKSRFT.....AG--.-R.G...NIT....N...K.PTEVNH..P.IK..KEGENFls.............vgK--GDHD...ES..R..VMLLKELYQKDNELNIVRKKHKKYKSITVALASIIGMMLLRNIGSLLYDTVTR-----lnqksn.................................................................................
W7JDS7_PLAFA/2-132                   ...................KNKLSTLFFItIFLILI.FIDSAKGDE..R----KNFWKSRFT.....AG--.-R.G...NIT....N...K.PTEVNH..P.IK..KEGENFls.............vgK--GDHD...ES..R..VMLLKELYQKDNELNIVRKKHKKYKSITVALASIIGMMLLRNIGSLLYDTVTR-----lnqksn.................................................................................
A0A024VS38_PLAFA/454-584             ...................KNKLSTLFFItIFLILI.FIDSAKGDE..R----KNFWKSRFT.....AG--.-R.G...NIT....N...K.PTEVNH..P.IK..KEGENFls.............vgK--GDHD...ES..R..VMLLKELYQKDNELNIVRKKHKKYKSITVALASIIGMMLLRNIGSLLYDTVTR-----lnqksn.................................................................................
A0A1D3THZ1_9APIC/26-105              .......gggnsgpkkkvq----------.------.---------..--------------.....----.--.-...---....-...-.------..-.--..------.................KRSPEPL...ID..V..HELIGDMVKKEEELVKLSKKKSTYKTATTILATALGVVSALLLGGTGLVLYNTERGRH.......................................................................................
A0A384LP13_PLAKH/38-106              ..................k----------.------.---------..--------------.....----.--.-...---....-...-.------..-.--..------.................SKAPEPL...ID..V..HELIGEMVRKEEELINVTKKKSKYKLATTVLASALGLVSAVLLGGAGLVFYNAGNGRH.......................................................................................
W7JTD3_PLAFO/18-108                  keslaektnkgtgsgvssk----------.------.---------..--------------.....----.--.-...---....-...-.------..-.--..KKNK--.................KGSGEPL...ID..V..HDLISDMIKKEEELVEVNKRKSKYKLATSVLAGLLGVVSTVLLGGVGLVLYNTEKGRH.......................................................................................
A0A024W4Z2_PLAFA/18-108              keslaektnkgtgsgvssk----------.------.---------..--------------.....----.--.-...---....-...-.------..-.--..KKNK--.................KGSGEPL...ID..V..HDLISDMIKKEEELVEVNKRKSKYKLATSVLAGLLGVVSTVLLGGVGLVLYNTEKGRH.......................................................................................
A0A0L0CW34_PLAFA/2-132               ...................KNKLSTLFFItIFLILI.FIDSAKGDE..R----KNFWKSRFT.....AG--.-R.G...NIT....N...K.PTEVNH..P.IK..KEGENFls.............vgK--GDHD...ES..R..VMLLKELYQKDNELNIVRKKHKKYKSITVALASIIGMMLLRNIGSLLYDTVTR-----lnqksn.................................................................................
K6V7K9_9APIC/17-157                  ..................r-HKLPILLVI.NLFLLItFGDVVKGDN..IINKKKDIWKSRFT.....VGK-.GT.P...KKN....E...DfNDKNKD..K.DN.kKDKDDFl..............tsGNNKDDM...NDarS..IMLLREIYEKDNQLSIINRKKKKYKTATFTLGTLITIIALRALADLAVNGIA------kifkke.................................................................................
Q7RET0_PLAYO/2-151                   ...................KQKLHTFFVI.ICLVVVlYCGGIDGKQ..NNNIKRDMWMSRFF.....NHKN.GK.Y...MKN....E...K.KVEKSE..G.AN..KNNEILddihsddideivknvlkSENVDNQ...T-..-..LKIIKELDKKKNEIIIANKKKNLYKSSAFSMGVIFVGLALRELTALLVGLYLDKHPNT.......................................................................................
A5K5F2_PLAVS/2-143                   ..................r-HKLPILLVI.NLFLLItFGDVVKGDN..IINKKKDIWKYRFTvgkgtPKKN.ED.F...NDK....N...K.DKDKDN..K.KD..KDD--Fl..............tsGNHKDDM...ND..SrsIMLLREIYEKDNQLSIINRKKKKYKTATFTLGTLITIIALRAIADLAVKGI-------sklfqk.................................................................................
Q7RI01_PLAYO/2-148                   ...................NTKLYSLFFF.IYLIIV.YCATVQGNK..NSNGKADGHGLSFI.....KKVY.QN.S...NNK....D...K.HMLRTD..E.DG..------.................-------...--..-..----------------------------------------------------------igtfnikylykcvyytyiqiiqncssyfillheivlciinnfcfinpsgdvvidilkkeyvdphiiklvdivnkkeiinffnvlknr
A0A1A8WKF7_PLAMA/2-144               .................ky--KVSVLYVI.TVFLLIaFSDVIKGDNsnNDNKKKDMWKSRFS.....LGKG.TQ.KtdgDAN....E...K.NDKNHD..K.EK..KEKEFLmnn...........lkgADMNDPR...S-..-..VMLLKEIYDKDNQLSIISRKKKKYKTATFTLGTLLTIIAIRTLTEFAVKSIA------kffqk..................................................................................
A0A679L6W5_PLAKH/2-150               ...................KHKLPILLVI.NLFLLItFGDVIKGDN..ITNKKKDIWKSRFT.....AG-K.GT.P...KKN....E...N.SIDKNK..E.KDkgKDKDIKknkddf.....ltslinKEDMNDS...R-..N..IMLLREIYEKDNELSIIRRKKKKYKTATFTLGTLITIIALRAIADLAVKGI-------sklfeqeqs..............................................................................
Q7RGC6_PLAYO/41-107                  ...................----------.------.---------..--------------.....----.--.-...---....-...-.------..-.--..------.................-KHGEPV...IN..V..QDLISDMVRKEEEIVKLTKNKKSLRKINVALATALSVVSAILLGGAGLVMYNTEKGR-r......................................................................................
A0A1D3JCN4_9APIC/2-152               ...................KNKLSSLFVI.SFFLLVvFSNVIKGDN..NINKKRDMWISRFF.....LGKR.DQ.K...TDNdvseEehkA.KIEKAKieK.EK.kEKEEIL................tSNNKEDM...ND..VrsMLLLKEIYEKDNQLSIISRKKKKYKTATFTLGTLLTLIAVRALANLAVNGL-------tklvqkeena.............................................................................
W7JLS6_PLAFA/18-108                  keslaektnkgtgsgvssk----------.------.---------..--------------.....----.--.-...---....-...-.------..-.--..KKNK--.................KGSGEPL...ID..V..HDLISDMIKKEEELVEVNKRKSKYKLATSVLAGLLGVVSTVLLGGVGLVLYNTEKGRH.......................................................................................
#=GC seq_cons                        .....................+l..hhhh..hhhhl.h...h.Gpp.......ts....ph.......t.....................................cctc...................ptss-s.....-..s..h.Llp-hhcK-pELshlsKKKpKYKhuTssLAollulluhhhlGululshhsp............................................................................................
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