#=GF ID   CagD
#=GF AC   PF16567.6
#=GF DE   Pathogenicity island component CagD
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   pdb_3cwx
#=GF GA   25.00 25.00;
#=GF TC   462.50 462.30;
#=GF NC   23.10 21.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   19109970
#=GF RT   The Helicobacter pylori CagD (HP0545, Cag24) protein is
#=GF RT   essential for CagA translocation and maximal induction of
#=GF RT   interleukin-8 secretion.
#=GF RA   Cendron L, Couturier M, Angelini A, Barison N, Stein M, Zanotti
#=GF RA   G;
#=GF RL   J Mol Biol. 2009;386:204-217.
#=GF DR   INTERPRO; IPR032336;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   CagD is a tightly conserved family of proteins found in the
#=GF CC   pathogenic strains of Helicobacter species. It is one of some 30
#=GF CC   proteins, produced from the genomic insert termed the
#=GF CC   pathogenicity island, required for the type IV secretion system
#=GF CC   - T4SS - that delivers CagA oncoprotein toxin into the host
#=GF CC   cell. CagD is a covalent dimer in which each monomer folds as a
#=GF CC   single domain composed of five beta-strands and three
#=GF CC   alpha-helices.  CagD partially associates with the inner
#=GF CC   membrane, where it may be exposed to the periplasmic space; this
#=GF CC   may indicate that CagD is released into the supernatant during
#=GF CC   host cell infection in order then to bind to the host cell
#=GF CC   surface, or to be incorporated into the pilus structure [1].
#=GF SQ   1
#=GS O25277_HELPY/3-207  AC O25277.1
O25277_HELPY/3-207             NNNSNKKLRGFFVKVLLSLVVFSSYGLANDDKEAKKEVLEKEKNTPNGLVYTNLDFDSFKATIKNLKDKKVTFKEVNPDIIKDEVFDFVIVNRVLKKIKDLKHYDPVIEKIFDEKGKEMGLNVELQINPEVKDFFTFKSISTTNKQRCFLSLRGETREILCDDKLYNVLLAVFNSYDPNDLLKHISTVESLKKIFYTITCEAVYL
#=GC seq_cons                  NNNSNKKLRGFFVKVLLSLVVFSSYGLANDDKEAKKEVLEKEKNTPNGLVYTNLDFDSFKATIKNLKDKKVTFKEVNPDIIKDEVFDFVIVNRVLKKIKDLKHYDPVIEKIFDEKGKEMGLNVELQINPEVKDFFTFKSISTTNKQRCFLSLRGETREILCDDKLYNVLLAVFNSYDPNDLLKHISTVESLKKIFYTITCEAVYL
//