GenomeNet

Database: Pfam
Entry: Caskin1-CID
LinkDB: Caskin1-CID
Original site: Caskin1-CID 
#=GF ID   Caskin1-CID
#=GF AC   PF16600.5
#=GF DE   Caskin1 CASK-interaction domain
#=GF PI   CID;
#=GF AU   Punta M;0000-0002-0050-0676
#=GF SE   MobiDB:Q8WXD9
#=GF GA   30.00 30.00;
#=GF TC   31.10 30.80;
#=GF NC   29.40 29.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   12040031
#=GF RT   CASK participates in alternative tripartite complexes in which
#=GF RT   Mint 1 competes for binding with caskin 1, a novel CASK-binding
#=GF RT   protein.
#=GF RA   Tabuchi K, Biederer T, Butz S, Sudhof TC;
#=GF RL   J Neurosci. 2002;22:4264-4273.
#=GF RN   [2]
#=GF RM   21763699
#=GF RT   The molecular basis of the Caskin1 and Mint1 interaction with
#=GF RT   CASK.
#=GF RA   Stafford RL, Ear J, Knight MJ, Bowie JU;
#=GF RL   J Mol Biol. 2011;412:3-13.
#=GF DR   INTERPRO; IPR032232;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   The Caskin1 protein interacts with the CASK protein via this
#=GF CC   region [1].CASK and Caskin1 are synaptic scaffolding proteins.
#=GF CC   The binding motif on human Caskin1 is EEIWVLRK. A similar motif
#=GF CC   is found on protein MINT1 and protein TIAM1, both shown to be
#=GF CC   able to bind to CASK though the motif. MINT1 and TIAM1 are not
#=GF CC   part of this family [2]. This region is predicted to be natively
#=GF CC   unstructured.
#=GF SQ   149
#=GS A0A0P7WSE3_9TELE/374-432  AC A0A0P7WSE3.1
#=GS S9XEX4_CAMFR/270-318      AC S9XEX4.1
#=GS A0A2K5JNB6_COLAP/334-382  AC A0A2K5JNB6.1
#=GS A0A2D0PNN1_ICTPU/423-473  AC A0A2D0PNN1.1
#=GS A0A0R4IGS7_DANRE/367-418  AC A0A0R4IGS7.1
#=GS A0A0R4IIH7_DANRE/287-338  AC A0A0R4IIH7.1
#=GS H2UA09_TAKRU/344-402      AC H2UA09.1
#=GS A0A2D0SZ27_ICTPU/428-480  AC A0A2D0SZ27.1
#=GS F6Z3A3_MONDO/387-424      AC F6Z3A3.2
#=GS I3ITP1_DANRE/381-438      AC I3ITP1.1
#=GS W5MEY2_LEPOC/419-470      AC W5MEY2.1
#=GS H2NPT5_PONAB/353-401      AC H2NPT5.1
#=GS A0A1V4KSY5_PATFA/442-500  AC A0A1V4KSY5.1
#=GS L9L345_TUPCH/392-440      AC L9L345.1
#=GS A0A2D0PQB5_ICTPU/423-472  AC A0A2D0PQB5.1
#=GS A0A1U7T6N7_TARSY/291-339  AC A0A1U7T6N7.1
#=GS I3JHD3_ORENI/325-385      AC I3JHD3.1
#=GS S7PMT8_MYOBR/230-272      AC S7PMT8.1
#=GS A0A2I4B971_9TELE/374-432  AC A0A2I4B971.1
#=GS A0A2D0SZ36_ICTPU/369-421  AC A0A2D0SZ36.1
#=GS CSKI1_MOUSE/373-421       AC Q6P9K8.2
#=GS A0A2G9SMB2_LITCT/24-73    AC A0A2G9SMB2.1
#=GS I3J5L6_ORENI/368-416      AC I3J5L6.1
#=GS A0A2K5JN77_COLAP/334-382  AC A0A2K5JN77.1
#=GS M3W853_FELCA/373-421      AC M3W853.2
#=GS A0A1L8EYF4_XENLA/215-269  AC A0A1L8EYF4.1
#=GS A0A1S3QIF2_SALSA/32-75    AC A0A1S3QIF2.1
#=GS H0XTL5_OTOGA/373-423      AC H0XTL5.1
#=GS A0A1S3QLX6_SALSA/136-174  AC A0A1S3QLX6.1
#=GS A0A1S3SWA6_SALSA/411-467  AC A0A1S3SWA6.1
#=GS A0A151NIX6_ALLMI/12-63    AC A0A151NIX6.1
#=GS A0A2D0Q7K9_ICTPU/487-528  AC A0A2D0Q7K9.1
#=GS W5KH32_ASTMX/103-161      AC W5KH32.1
#=GS A0A2D0S9G0_ICTPU/399-447  AC A0A2D0S9G0.1
#=GS F6PLP7_ORNAN/252-291      AC F6PLP7.1
#=GS A0A2I4D0S3_9TELE/440-487  AC A0A2I4D0S3.1
#=GS G3WW39_SARHA/56-106       AC G3WW39.1
#=GS F1R097_DANRE/381-438      AC F1R097.2
#=GS G3TF78_LOXAF/373-421      AC G3TF78.1
#=GS G3PX04_GASAC/369-417      AC G3PX04.1
#=GS A0A1S3WHU5_ERIEU/290-336  AC A0A1S3WHU5.1
#=GS A0A2I4B8Z7_9TELE/374-432  AC A0A2I4B8Z7.1
#=GS A0A1S3S3M3_SALSA/341-390  AC A0A1S3S3M3.1
#=GS H3D932_TETNG/341-400      AC H3D932.1
#=GS A0A1A6HQS9_NEOLE/355-403  AC A0A1A6HQS9.1
#=GS U3IFU2_ANAPL/271-321      AC U3IFU2.1
#=GS A0A1V4KUA6_PATFA/370-428  AC A0A1V4KUA6.1
#=GS G1MHJ7_AILME/341-389      AC G1MHJ7.1
#=GS A0A1S3S3M2_SALSA/114-164  AC A0A1S3S3M2.1
#=GS A0A0P7XQB2_9TELE/113-171  AC A0A0P7XQB2.1
#=GS U3IFU9_ANAPL/271-321      AC U3IFU9.1
#=GS H0VK50_CAVPO/373-421      AC H0VK50.2
#=GS F7BS58_XENTR/323-380      AC F7BS58.1
#=GS H2TLU6_TAKRU/368-419      AC H2TLU6.1
#=GS U3IFS2_ANAPL/282-320      AC U3IFS2.1
#=GS A0A1U8D9K4_ALLSI/366-417  AC A0A1U8D9K4.1
#=GS A0A2D0S9F9_ICTPU/420-468  AC A0A2D0S9F9.1
#=GS G3RE86_GORGO/336-384      AC G3RE86.2
#=GS A0A1U7R8C0_MESAU/373-421  AC A0A1U7R8C0.1
#=GS W5MEW9_LEPOC/450-507      AC W5MEW9.1
#=GS M4A2P3_XIPMA/374-432      AC M4A2P3.1
#=GS H2QAC6_PANTR/373-421      AC H2QAC6.2
#=GS A0A2D0SYK3_ICTPU/428-480  AC A0A2D0SYK3.1
#=GS H2LXW7_ORYLA/372-425      AC H2LXW7.1
#=GS A0A1S3EQN2_DIPOR/291-339  AC A0A1S3EQN2.1
#=GS U3IFW2_ANAPL/285-327      AC U3IFW2.1
#=GS A0A2I4BGK6_9TELE/417-448  AC A0A2I4BGK6.1
#=GS A0A2D0SA96_ICTPU/420-468  AC A0A2D0SA96.1
#=GS A0A1U8CN26_MESAU/349-397  AC A0A1U8CN26.1
#=GS A0A2D0PM41_ICTPU/312-362  AC A0A2D0PM41.1
#=GS A0A2D0PRD0_ICTPU/423-473  AC A0A2D0PRD0.1
#=GS W5Q8S8_SHEEP/382-430      AC W5Q8S8.1
#=GS H3CLZ0_TETNG/377-428      AC H3CLZ0.1
#=GS A0A1S3QLX6_SALSA/89-133   AC A0A1S3QLX6.1
#=GS F7E8C3_CALJA/56-104       AC F7E8C3.1
#=GS A0A1S3QIF2_SALSA/79-117   AC A0A1S3QIF2.1
#=GS I3LCF2_PIG/373-421        AC I3LCF2.2
#=GS A0A286XKY8_CAVPO/373-421  AC A0A286XKY8.1
#=GS H2UA10_TAKRU/344-402      AC H2UA10.1
#=GS A0A1S3NFU4_SALSA/374-432  AC A0A1S3NFU4.1
#=GS A0A2D0PNQ7_ICTPU/423-473  AC A0A2D0PNQ7.1
#=GS F7IBQ6_CALJA/427-468      AC F7IBQ6.1
#=GS A0A1S3SWA8_SALSA/414-470  AC A0A1S3SWA8.1
#=GS A0A226PQT6_COLVI/299-357  AC A0A226PQT6.1
#=GS G1P245_MYOLU/342-390      AC G1P245.1
#=GS H2TLU5_TAKRU/368-418      AC H2TLU5.1
#=GS A0A1S3S3N4_SALSA/341-391  AC A0A1S3S3N4.1
#=GS F1MB71_BOVIN/343-391      AC F1MB71.2
#=GS A0A0F8C3E1_LARCR/522-569  AC A0A0F8C3E1.1
#=GS A0A0R4IRE4_DANRE/373-425  AC A0A0R4IRE4.1
#=GS H2MQ14_ORYLA/330-388      AC H2MQ14.1
#=GS L5KGS9_PTEAL/362-411      AC L5KGS9.1
#=GS G3HBR4_CRIGR/347-395      AC G3HBR4.1
#=GS A0A1S3RE16_SALSA/292-350  AC A0A1S3RE16.1
#=GS W5KGY2_ASTMX/367-411      AC W5KGY2.1
#=GS A0A1L8EQT3_XENLA/428-485  AC A0A1L8EQT3.1
#=GS A0A1S3NGF0_SALSA/374-432  AC A0A1S3NGF0.1
#=GS G3NQS9_GASAC/344-403      AC G3NQS9.1
#=GS A0A1U7R606_MESAU/373-421  AC A0A1U7R606.1
#=GS M7BMH3_CHEMY/379-429      AC M7BMH3.1
#=GS F6PM80_HORSE/346-394      AC F6PM80.1
#=GS F1Q1A7_CANLF/342-390      AC F1Q1A7.2
#=GS L5LVN5_MYODS/375-421      AC L5LVN5.1
#=GS F6ZWE4_HORSE/344-392      AC F6ZWE4.1
#=GS A0A087X7X2_POEFO/427-479  AC A0A087X7X2.2
#=GS A0A2D0SZ44_ICTPU/344-394  AC A0A2D0SZ44.1
#=GS A0A087YMJ8_POEFO/386-439  AC A0A087YMJ8.2
#=GS A0A2D0SZK3_ICTPU/407-453  AC A0A2D0SZK3.1
#=GS A0A0D9RER6_CHLSB/373-421  AC A0A0D9RER6.1
#=GS A0A2I4BGK6_9TELE/368-414  AC A0A2I4BGK6.1
#=GS F7E897_CALJA/343-391      AC F7E897.1
#=GS A0A1S3RB65_SALSA/423-473  AC A0A1S3RB65.1
#=GS CSKI1_HUMAN/373-421       AC Q8WXD9.1
#=GS I3L7B5_PIG/373-421        AC I3L7B5.2
#=GS I3KTW6_ORENI/370-424      AC I3KTW6.1
#=GS A0A2I4B945_9TELE/374-432  AC A0A2I4B945.1
#=GS I3J5L5_ORENI/368-416      AC I3J5L5.1
#=GS D3ZE17_RAT/373-421        AC D3ZE17.2
#=GS A0A2D0SYL8_ICTPU/428-480  AC A0A2D0SYL8.1
#=GS K7E7V4_ORNAN/27-85        AC K7E7V4.1
#=GS U3IFT0_ANAPL/286-323      AC U3IFT0.1
#=GS A0A2I4BGM4_9TELE/417-448  AC A0A2I4BGM4.1
#=GS I3JHD2_ORENI/456-514      AC I3JHD2.1
#=GS U3IFX3_ANAPL/56-101       AC U3IFX3.1
#=GS H3CLZ1_TETNG/377-428      AC H3CLZ1.1
#=GS A0A226NM71_CALSU/379-437  AC A0A226NM71.1
#=GS A0A096NL17_PAPAN/373-421  AC A0A096NL17.1
#=GS M4AAX2_XIPMA/376-422      AC M4AAX2.1
#=GS G1RDA4_NOMLE/324-372      AC G1RDA4.2
#=GS A0A2I2U7T5_FELCA/373-421  AC A0A2I2U7T5.1
#=GS G5BY43_HETGA/360-408      AC G5BY43.1
#=GS G1N367_MELGA/344-401      AC G1N367.2
#=GS F6QHA2_MACMU/341-389      AC F6QHA2.2
#=GS A0A2I3TA85_PANTR/373-421  AC A0A2I3TA85.1
#=GS G7Q084_MACFA/349-397      AC G7Q084.1
#=GS A0A2G9SMB7_LITCT/46-103   AC A0A2G9SMB7.1
#=GS A0A2D0SAV2_ICTPU/419-467  AC A0A2D0SAV2.1
#=GS A0A0R4IGS7_DANRE/415-451  AC A0A0R4IGS7.1
#=GS I3N4E2_ICTTR/341-389      AC I3N4E2.2
#=GS A0A2I4BGM4_9TELE/368-414  AC A0A2I4BGM4.1
#=GS H2UA11_TAKRU/366-409      AC H2UA11.1
#=GS A0A2I4CHL0_9TELE/407-460  AC A0A2I4CHL0.1
#=GS G3UHQ2_LOXAF/373-421      AC G3UHQ2.1
#=GS A0A2K5NVJ1_CERAT/373-421  AC A0A2K5NVJ1.1
#=GS A0A218U7Z2_9PASE/376-434  AC A0A218U7Z2.1
#=GS A0A0Q3U620_AMAAE/20-78    AC A0A0Q3U620.1
#=GS H2UA08_TAKRU/344-402      AC H2UA08.1
#=GS CSKI1_RAT/373-421         AC Q8VHK2.1
#=GS A0A0R4IIH7_DANRE/335-371  AC A0A0R4IIH7.1
A0A0P7WSE3_9TELE/374-432             ............EEIWVLRKP.TA.V.GDRSSVGSS....GSVASARSSGSGQSAGs..ssQALHAQAE.GVKLLATVLSQ...............
S9XEX4_CAMFR/270-318                 ............EEIWVLRKP.FA.G.GDRS--GSL....SSVAGGRSSGG-----.....HTLHAGSE.GVKLLATVLSQ...............
A0A2K5JNB6_COLAP/334-382             ............EEIWVLRKP.FA.G.GDRS--GSI....SGVAGSRGSGG-----.....HTLHAGSE.GIKLLATVLSQ...............
A0A2D0PNN1_ICTPU/423-473             ............EDIWVLRNS.CA.A.GDRNSVGST....GSVGSTRSAGSGQSTE.....NT------.-----------ttsngqhstnae...
A0A0R4IGS7_DANRE/367-418             ............EEIWVLRKP.LAaG.GSVGSMGST....GSLS-GRSSASGQSSN.....ANAH----.-----------ltnspvpvptt....
A0A0R4IIH7_DANRE/287-338             ............EEIWVLRKP.LAaG.GSVGSMGST....GSLS-GRSSASGQSSN.....ANAH----.-----------ltnspvpvptt....
H2UA09_TAKRU/344-402                 ............EEIWVLRKP.VA.G.GDRSSLGSS....SSVNSVRSSGSGQSAAs..apHILHAQAE.GVKLLATVLSQ...............
A0A2D0SZ27_ICTPU/428-480             ............EEIWVLRKP.AA.G.GDRSSVSSS....SS---ARSSGSGQSNT.....HILHAHAE.GVKLLATVLSQ...............
F6Z3A3_MONDO/387-424                 ..........lv---------.LA.G.ADRS--SSL....GGVASGRSGGSGS---.....HALHASSE.GVKV-------g..............
I3ITP1_DANRE/381-438                 ............EEIWVLRKP.VA.G.GDRSSVGSS....GSVASARSSGSGQSAGs...tSILHAQAE.GVKLLATVLSQ...............
W5MEY2_LEPOC/419-470                 .........rcg---------.-Q.G.GDRSSVGSS....GSVASARSSGSGQSAGg..svHALHAQAE.GVKLLATVLSQ...............
H2NPT5_PONAB/353-401                 ............EEIWVLRKP.FA.G.GDRS--GSI....SGVAGGRGSGG-----.....HALHAGSE.GIKLLATVLSQ...............
A0A1V4KSY5_PATFA/442-500             ............EEIWVLRKP.FA.G.GDRSSLGST....GSVASARSSGSGQSAGs..gaHALHASSE.GVKLLATVLSQ...............
L9L345_TUPCH/392-440                 ............EEIWVLRKP.FT.G.GDRS--GSL....SGVASSRSSGG-----.....HALHAGSE.GVKLLATVLSQ...............
A0A2D0PQB5_ICTPU/423-472             ............EDIWVLRNS.CA.-.GDRNSVGST....GSVGSTRSAGSGQSTE.....NT------.-----------ttsngqhstnae...
A0A1U7T6N7_TARSY/291-339             ............EEIWVLRKP.FA.G.GERS--SSV....SGMAGSRGSGS-----.....HALHAGSE.GVKLLATVLSQ...............
I3JHD3_ORENI/325-385                 ............EEIWVLRKP.VAaG.GDRSSVGSS....GSVTSVRSSGSGQSAGs..aaHILHAQAEkGVKLLATVLSQ...............
S7PMT8_MYOBR/230-272                 .........grk---------.CT.C.GDRS--GSL....SSVAVGRSSGA-----.....HTLHAGSE.GVKLLATVLSQ...............
A0A2I4B971_9TELE/374-432             ............EEIWVLRKP.VA.G.GDRSSVGSS....GSVTSVRSSGSGQSAGs..aaHILHAQAE.GVKLLATVLSQ...............
A0A2D0SZ36_ICTPU/369-421             ............EEIWVLRKP.AA.G.GDRSSVSSS....SS---ARSSGSGQSNT.....HILHAHAE.GVKLLATVLSQ...............
CSKI1_MOUSE/373-421                  ............EEIWVLRKP.FA.G.GDRS--GSL....SNVAGGRSTGG-----.....HALHAGSE.GVKLLATVLSQ...............
A0A2G9SMB2_LITCT/24-73               .........err---------.--.S.GDRSSMGST....GSGASGRSSGSGQSANs...pHAIPASAE.GVKLLATVLSQ...............
I3J5L6_ORENI/368-416                 ............EDIWVLRKP.LA.G.GERS--GSV....GSLGSVRSSSSLR---.....--LHAQAE.GVKLLATVLSQ...............
A0A2K5JN77_COLAP/334-382             ............EEIWVLRKP.FA.G.GDRS--GSI....SGVAGSRGSGG-----.....HTLHAGSE.GIKLLATVLSQ...............
M3W853_FELCA/373-421                 ............EEIWVLRKP.FA.G.GDRS--GSL....GSVAGGRSSGG-----.....HTLHAGSE.GVKVGAA----lash...........
A0A1L8EYF4_XENLA/215-269             ............EEIWVLRKP.FA.G.GDRSSMGST....GS---GRSSGSGQSAGs...aHAIHAGAE.GVKLLATVLSQ...............
A0A1S3QIF2_SALSA/32-75               ............EDVWVLRKP.LA.G.GDHS--SSV....GSLGSVRSLGSVQSSG.....NTQHAS--.-----------nta............
H0XTL5_OTOGA/373-423                 ............EEIWVLRKP.FA.G.GDRSSSSSV....SSVAGGRGSGG-----.....HALHAGSE.GVKLLATVLSQ...............
A0A1S3QLX6_SALSA/136-174             .....atahatn---------.--.-.---------....------TPPGSLNTHGl..naPGLHAQAE.GVKLLATVMSQ...............
A0A1S3SWA6_SALSA/411-467             ............EDIWVLRNS.HT.A.GDRNSVGSAgssaGSVGSSRSAGSGQSSE.....N-------.-----------sfgqngshtrqttat
A0A151NIX6_ALLMI/12-63               ...........f--------P.LA.G.GDRSSLGST....GSVASARSSGSGQSAGs..ggHALHAGSE.GVKLLATVLSQ...............
A0A2D0Q7K9_ICTPU/487-528             sspvpvpttpth---------.--.-.---------....--------STGLNTHGv..nvPGLHAQAE.GVKLLATVLSQ...............
W5KH32_ASTMX/103-161                 ............EEIWVLRKP.VA.G.GDRSSVGSS....GSVASARSSGSGQSAGs..ssHILHAQAE.GVKLLATVLSQ...............
A0A2D0S9G0_ICTPU/399-447             ............EDIWVLRSS.FT.-.GDRNSVGSA....GSVGSSRSAGSGQSTE....gNFTH----.-----------naqhqtst.......
F6PLP7_ORNAN/252-291                 .........isc--------P.FA.A.GDRNSVGSE....GSLGSVRSAGSGQSSE....gN-------.-----------nghvpg.........
A0A2I4D0S3_9TELE/440-487             ............EDIWVLRGS.CH.A.GDRNSVGST....GSVGSTRSAGSGQSTE.....--------.-----------snsatnghqhn....
G3WW39_SARHA/56-106                  ............EEIWVLRKP.FT.G.ADRS--SSL....GGVASGRSGGSGS---.....HALHAGSE.GVKLLATVLSQ...............
F1R097_DANRE/381-438                 ............EEIWVLRKP.VA.G.GDRSSVGSS....GSVASARSSGSGQSAGs...tSILHAQAE.GVKLLATVLSQ...............
G3TF78_LOXAF/373-421                 ............EEIWVLRKP.FA.G.GDRS--SSL....SSVPGGRGSGG-----.....HVLHAGSE.GVKLLATVLSQ...............
G3PX04_GASAC/369-417                 ............EDIWVLRKP.LA.V.AERS--GSV....GSIGSVRSTSSL----.....-GLHAQAE.GVKLLATVLAQ...............
A0A1S3WHU5_ERIEU/290-336             ............EEIWVLRKP.FA.G.GDRS--GSL....SS--AGRSGGG-----.....HALHAGAE.GVKLLATVLSQ...............
A0A2I4B8Z7_9TELE/374-432             ............EEIWVLRKP.VA.G.GDRSSVGSS....GSVTSVRSSGSGQSAGs..aaHILHAQAE.GVKLLATVLSQ...............
A0A1S3S3M3_SALSA/341-390             ............EDIWVLRNS.HT.A.GDRNSVGST....GSVGSTRSAGSGQSTEsntapN-------.-----------gqhqqtt........
H3D932_TETNG/341-400                 ............EEIWVLRKPvFA.G.GDRSSLGSS....SSVNSVRSSGSGQSAGs..apHILHAQAE.GVKLLATVLSQ...............
A0A1A6HQS9_NEOLE/355-403             ............EEIWVLRKP.FA.G.GDRS--GSL....SNVAGGRSGGG-----.....HALHAGSE.GVKLLATVLSQ...............
U3IFU2_ANAPL/271-321                 ............EEIWVLRKP.FA.G.GDRSSLGST....SG--SGQSAGSGA---.....HALHASSE.GVKMLSPVL--la.............
A0A1V4KUA6_PATFA/370-428             ............EEIWVLRKP.FA.G.GDRSSLGST....GSVASARSSGSGQSAGs..gaHALHASSE.GVKLLATVLSQ...............
G1MHJ7_AILME/341-389                 ............EEIWVLRKP.FA.G.GDRG--GSL....SAVAGARGSGG-----.....HTLHAGSE.GVKLLATVLSQ...............
A0A1S3S3M2_SALSA/114-164             ............EDIWVLRNS.HTaA.GDRNSVGST....GSVGSTRSAGSGQSTEsntapN-------.-----------gqhqqtt........
A0A0P7XQB2_9TELE/113-171             ............EEIWVLRKP.FA.G.ADRSSAGSS....GSVTSARSSGSGQSAGs..nvHTLHAQAE.GVKLLATVLSQ...............
U3IFU9_ANAPL/271-321                 ............EEIWVLRKP.FA.G.GDRSSLGST....SG--SGQSAGSGA---.....HALHASSE.GVKMLSPVL--la.............
H0VK50_CAVPO/373-421                 ............EEIWVLRKP.FA.G.GDRS--GSL....SSVAGGRSGGG-----.....HTLHAGSE.GVKLLATVLSQ...............
F7BS58_XENTR/323-380                 ............EEIWVLRKP.LA.G.GDRSSMGST....GSATSGRSSGSGQSAGs...aHAIHAGAE.GVKLLATVLSQ...............
H2TLU6_TAKRU/368-419                 ............EDIWVLRKP.LA.G.GERS-----....GSVAN--TPGGVNTHGl..naPGLHAQAE.GVKLLATVLSQ...............
U3IFS2_ANAPL/282-320                 .........pva---------.QA.G.GDRSSLGST....GS---GQSAGSGA---.....HALHASSE.GVKV-------rl.............
A0A1U8D9K4_ALLSI/366-417             ............EEIWVLRKP.FA.G.GDRSSLGST....GSVASARSSGSGQSAGs..ggHALHAGSE.GVK--------r..............
A0A2D0S9F9_ICTPU/420-468             ............EDIWVLRSS.FT.-.GDRNSVGSA....GSVGSSRSAGSGQSTE....gNFTH----.-----------naqhqtst.......
G3RE86_GORGO/336-384                 ............EEIWVLRKP.FA.G.GDRS--GSI....SGMAGGRGSGG-----.....HALHAGSE.GVKLLATVLSQ...............
A0A1U7R8C0_MESAU/373-421             ............EEIWVLRKP.FA.G.GDRS--GSL....SNVAGGRSGGG-----.....HALHAGSE.GVKLLATVLSQ...............
W5MEW9_LEPOC/450-507                 .........war----VYKKT.PA.G.GDRSSVGSS....GSVASARSSGSGQSAGg..svHALHAQAE.GVKLLATVLSQ...............
M4A2P3_XIPMA/374-432                 ............EEIWVLRKP.VA.G.GDRSSVGSS....GSVTSVRSSGSGQSATn..aaHILHAQAE.GVKLLATVLSQ...............
H2QAC6_PANTR/373-421                 ............EEIWVLRKP.FA.G.GDRS--GSI....SGMAGGRGSGG-----.....HALHAGSE.GVKLLATVLSQ...............
A0A2D0SYK3_ICTPU/428-480             ............EEIWVLRKP.AA.G.GDRSSVSSS....SS---ARSSGSGQSNT.....HILHAHAE.GVKLLATVLSQ...............
H2LXW7_ORYLA/372-425                 ............EDIWVLRKP.LA.G.GERS--GST....GSLGSVRSSSSLQSSG.....NTLHAQSE.GVKLLATVLSQ...............
A0A1S3EQN2_DIPOR/291-339             ............EEIWVLRKP.FA.G.GERS--GSL....SSGTGGRSGGG-----.....HTLHAGSE.GVKLLATVLSQ...............
U3IFW2_ANAPL/285-327                 ........rcpr---------.GT.G.GDRSSLGST....GSSGSGQSAGSGA---.....HALHASSE.GVKV-------rl.............
A0A2I4BGK6_9TELE/417-448             ........aptp---------.--.-.---------....----------GVNTHGl..naPGLHAQAE.GVKLLATVLSQ...............
A0A2D0SA96_ICTPU/420-468             ............EDIWVLRSS.FT.-.GDRNSVGSA....GSVGSSRSAGSGQSTE....gNFTH----.-----------naqhqtst.......
A0A1U8CN26_MESAU/349-397             ............EEIWVLRKP.FA.G.GDRS--GSL....SNVAGGRSGGG-----.....HALHAGSE.GVKLLATVLSQ...............
A0A2D0PM41_ICTPU/312-362             ............EDIWVLRNS.CA.A.GDRNSVGST....GSVGSTRSAGSGQSTE.....NT------.-----------ttsngqhstnae...
A0A2D0PRD0_ICTPU/423-473             ............EDIWVLRNS.CA.A.GDRNSVGST....GSVGSTRSAGSGQSTE.....NT------.-----------ttsngqhstnae...
W5Q8S8_SHEEP/382-430                 ............EEIWVLRKP.FA.G.GDRS--GSL....SSAAGGRSSGG-----.....HALHAGSE.GVKLLATVLSQ...............
H3CLZ0_TETNG/377-428                 ............EEIWVLRKS.GApA.GDRSSVGST....GSVGSTRSAGSGQSS-.....----TGGD.GPRVWSTCIRS...............
A0A1S3QLX6_SALSA/89-133              ............EDVWVLRKP.LA.G.GDRS--SSV....GSLGSVRPLGSVQSSV.....NTQHAS--.-----------ntap...........
F7E8C3_CALJA/56-104                  ............EEIWVLRKP.FA.G.GERS--GSV....SGVAGGRGSGG-----.....QALHAGSE.GVKLLATVLSQ...............
A0A1S3QIF2_SALSA/79-117              .....atahatn---------.--.-.---------....------TPPGSLNTHGl..naPGLHAQAE.GVKLLATVMSQ...............
I3LCF2_PIG/373-421                   ............EEIWVLRKP.FA.G.GDRS--GSL....SGVAGGRSSGG-----.....HTLHAGAE.GVKLLATVLSQ...............
A0A286XKY8_CAVPO/373-421             ............EEIWVLRKP.FA.G.GDRS--GSL....SSVAGGRSGGG-----.....HTLHAGSE.GVKLLATVLSQ...............
H2UA10_TAKRU/344-402                 ............EEIWVLRKP.VA.G.GDRSSLGSS....SSVNSVRSSGSGQSAAs..apHILHAQAE.GVKLLATVLSQ...............
A0A1S3NFU4_SALSA/374-432             ............EEIWVLRKP.GP.G.GDRSSVGSS....GSVTSVRSSGSGQSAGs..stHIIHAQAE.GVKLLATVLSQ...............
A0A2D0PNQ7_ICTPU/423-473             ............EDIWVLRNS.CA.A.GDRNSVGST....GSVGSTRSAGSGQSTE.....NT------.-----------ttsngqhstnae...
F7IBQ6_CALJA/427-468                 .........wll--------P.PT.A.GDRNSVGSE....GSVGSIRSAGSGQSSE.....--------.-----------gtnghgpgll.....
A0A1S3SWA8_SALSA/414-470             ............EDIWVLRNS.HT.A.GDRNSVGSAgssaGSVGSSRSAGSGQSSE.....N-------.-----------sfgqngshtrqttat
A0A226PQT6_COLVI/299-357             ............EEIWVLRKP.FT.G.GDRSSLGST....GSVASARSSGSGQSTGs..gaHALHAGSE.GVKLLATVLSQ...............
G1P245_MYOLU/342-390                 ............EEIWVLRKP.FA.G.GDRS--GSL....SSVAVGRSSGA-----.....HTLHAGSE.GVKLLATVLSQ...............
H2TLU5_TAKRU/368-418                 ............EDIWVLRKP.LA.G.GERS-----....GS-AN--TPGGVNTHGl..naPGLHAQAE.GVKLLATVLSQ...............
A0A1S3S3N4_SALSA/341-391             ............EDIWVLRNS.HTaA.GDRNSVGST....GSVGSTRSAGSGQSTEsntapN-------.-----------gqhqqtt........
F1MB71_BOVIN/343-391                 ............EEIWVLRKP.FA.G.GDRS--GSL....SSAAGGRSVGG-----.....HTLHAGSE.GVKLLATVLSQ...............
A0A0F8C3E1_LARCR/522-569             ............EDIWVLRDS.CH.A.GDRNSVGST....GSVGSTRSAGSGQSTE.....--------.-----------snnapnglqhn....
A0A0R4IRE4_DANRE/373-425             ............EEIWVLRKP.LAaG.GSVGSMGST....GSLS-GRSSASGQSR-.....--LHAQAE.GVKLLATVLSQ...............
H2MQ14_ORYLA/330-388                 ............EEIWVLRKP.VA.G.GDRSSVGSS....GSVTSLRSSGSGQSAGs..apHILHAQAE.GVKLLATVLSQ...............
L5KGS9_PTEAL/362-411                 ............EEIWVLRKP.FAaG.GDRS--GSL....SSVAGGRSSGA-----.....HTLHAGSE.GVKLLATVLSQ...............
G3HBR4_CRIGR/347-395                 ............EEIWVLRKP.FA.G.GDRS--GSL....SNVAGGRSGGG-----.....HALHAGSE.GVKLLATVLSQ...............
A0A1S3RE16_SALSA/292-350             ............EEIWVLRKP.GP.G.GDRSSVGSS....GSVTSVRSSGSGQSAGs..stHIIHAQAE.GVKLLATVLSQ...............
W5KGY2_ASTMX/367-411                 .........lfl--------P.PV.A.GDRNSVGST....GSVGSTRSAGSGQSTEsnnapNGLHQ---.-----------htt............
A0A1L8EQT3_XENLA/428-485             ............EEIWVLRKP.FA.G.GDRSSMGST....GSATSGRSSGSGQSAGs...aHAIHAGAE.GVKLLATLLSQ...............
A0A1S3NGF0_SALSA/374-432             ............EEIWVLRKP.GP.G.GDRSSVGSS....GSVTSVRSSGSGQSAGs..stHIIHAQAE.GVKLLATVLSQ...............
G3NQS9_GASAC/344-403                 ............EEIWVLRKS.VAaG.GDRSSLGSS....GSVTSVRSSGSGQSAGs..tgHVLHAQAE.GVKLLATVLSQ...............
A0A1U7R606_MESAU/373-421             ............EEIWVLRKP.FA.G.GDRS--GSL....SNVAGGRSGGG-----.....HALHAGSE.GVKLLATVLSQ...............
M7BMH3_CHEMY/379-429                 ..........wq---------.-A.G.GDRSSLGST....GSVASARSSGRGQSTGs..gsHALHAGSE.GVKLLATVLSQ...............
F6PM80_HORSE/346-394                 ............EEIWVLRKP.FA.G.GDRS--GSL....SSVAGGRSSGG-----.....HTLHAGSE.GVKLLATVLSQ...............
F1Q1A7_CANLF/342-390                 ............EEIWVLRKP.FA.G.GDRS--GSL....SGAAGARSGGG-----.....HALHAGSE.GVKLLATVLSQ...............
L5LVN5_MYODS/375-421                 .......vkrag-------KS.YP.G.GDRS--GSL....SSVAVGRSSGA-----.....HSLHAGSE.GVKLLATVLSQ...............
F6ZWE4_HORSE/344-392                 ............EEIWVLRKP.FA.G.GDRS--GSL....SSVAGGRSSGG-----.....HTLHAGSE.GVKLLATVLSQ...............
A0A087X7X2_POEFO/427-479             ...........t--------P.TApG.GDRSSVGSS....GSVTSVRSSGSGQSATs..aaHILHAQAE.GVKLLATVLSQ...............
A0A2D0SZ44_ICTPU/344-394             .........vis------KRP.GAtG.GDRSSVSSS....SS---ARSSGSGQSNT.....HILHAHAE.GVKLLATVLSQ...............
A0A087YMJ8_POEFO/386-439             ...........q-DIWVLRSS.PT.-.GDRNSVGST....GSVGSSRSAGSGQSSEsgrkqN-------.-----------gthirhhadagk...
A0A2D0SZK3_ICTPU/407-453             ........pisq---------.-K.G.GDRSSVSSS....SS---ARSSGSGQSNT.....HILHAHAE.GVKLLATVLSQ...............
A0A0D9RER6_CHLSB/373-421             ............EEIWVLRKP.FA.G.GDRS--GSI....SGVAGSRGSGG-----.....HTLHAGSE.GIKLLATVLSQ...............
A0A2I4BGK6_9TELE/368-414             ............EDIWVLRKP.MA.G.GERS--GSV....GSLGSXRSSSSLQSSGn...tHVLTT---.-----------papsp..........
F7E897_CALJA/343-391                 ............EEIWVLRKP.FA.G.GERS--GSV....SGVAGGRGSGG-----.....QALHAGSE.GVKLLATVLSQ...............
A0A1S3RB65_SALSA/423-473             ............EDIWVLRNS.HTaA.GDRNSVGST....GSVGSTRSAGSGQSTEsntapN-------.-----------gqhqqtt........
CSKI1_HUMAN/373-421                  ............EEIWVLRKP.FA.G.GDRS--GSI....SGMAGGRGSGG-----.....HALHAGSE.GVKLLATVLSQ...............
I3L7B5_PIG/373-421                   ............EEIWVLRKP.FA.G.GDRS--GSL....SGVAGGRSSGG-----.....HTLHAGAE.GVKLLATVLSQ...............
I3KTW6_ORENI/370-424                 ...........q-EIWVLRSS.PT.GkSDRNSVGSA....GSVGSSRSAGSGQSSEsghkqN-------.-----------gihcchnadag....
A0A2I4B945_9TELE/374-432             ............EEIWVLRKP.VA.G.GDRSSVGSS....GSVTSVRSSGSGQSAGs..aaHILHAQAE.GVKLLATVLSQ...............
I3J5L5_ORENI/368-416                 ............EDIWVLRKP.LA.G.GERS--GSV....GSLGSVRSSSSLR---.....--LHAQAE.GVKLLATVLSQ...............
D3ZE17_RAT/373-421                   ............EEIWVLRKP.FA.G.GDRS--GSL....SNVAGGRSTGG-----.....HALHAGAE.GVKLLATVLSQ...............
A0A2D0SYL8_ICTPU/428-480             ............EEIWVLRKP.AA.G.GDRSSVSSS....SS---ARSSGSGQSNT.....HILHAHAE.GVKLLATVLSQ...............
K7E7V4_ORNAN/27-85                   ............EDIWVLRKP.FA.G.GDRSSLGST....GSVASARSSGSGQSGGs..gvHTLHPGSE.GVKLLATVLSQ...............
U3IFT0_ANAPL/286-323                 ..........pr--------T.CA.G.GDRSSLGST....GS---GQSAGSGA---.....HALHASSE.GVK--------qc.............
A0A2I4BGM4_9TELE/417-448             ........aptp---------.--.-.---------....----------GVNTHGl..naPGLHAQAE.GVKLLATVLSQ...............
I3JHD2_ORENI/456-514                 ............EEIWVLRKP.VA.G.GDRSSVGSS....GSVTSVRSSGSGQSAGs..aaHILHAQAE.GVKLLATVLSQ...............
U3IFX3_ANAPL/56-101                  ............EEIWVLRKP.FA.G.GDRSSLGST....SG--SGQSAGSGA---.....HALHASSE.GVKV-------rl.............
H3CLZ1_TETNG/377-428                 ............EEIWVLRKS.GApA.GDRSSVGST....GSVGSTRSAGSGQSS-.....----TGGD.GPRVWSTCIRS...............
A0A226NM71_CALSU/379-437             ............EEIWVLRKP.FT.G.GDRSSLGST....GSVASARSSGSGQSTGs..gaHALHAGSE.GVKLLATVLSQ...............
A0A096NL17_PAPAN/373-421             ............EEIWVLRKP.FA.G.GDRS--GSI....SGVAGSRGSGG-----.....HTLHPGSE.GIKLLATVLSQ...............
M4AAX2_XIPMA/376-422                 ...........q-DIWVLRSS.PT.-.GDRNSVGST....GSVGSSRSAGSGQSS-.....---ESGPE.GAK--------hirl...........
G1RDA4_NOMLE/324-372                 ............EEIWVLRKP.FA.V.GDRS--GSI....SGMAGGRGSGG-----.....HALHAGSE.GVKLLATVLSQ...............
A0A2I2U7T5_FELCA/373-421             ............EEIWVLRKP.FA.G.GDRS--GSL....GSVAGGRSSGG-----.....HTLHAGSE.GVKVGAA----lash...........
G5BY43_HETGA/360-408                 ............EEIWVLRKP.FA.G.GDRS--GSL....SSVAGGRSGGG-----.....HTLHAGSE.GVKLLATVLSQ...............
G1N367_MELGA/344-401                 ............EEIWVLRKP.FT.G.GDRSSLGST....GSVASARSSGSGQSTGs..gaHALHAGSE.GVKL-------gdslla.........
F6QHA2_MACMU/341-389                 ............EEIWVLRKP.FT.G.GDRS--GSI....SGVAGSRGSGG-----.....HTLHAGSE.GIKLLATVLSQ...............
A0A2I3TA85_PANTR/373-421             ............EEIWVLRKP.FA.G.GDRS--GSI....SGMAGGRGSGG-----.....HALHAGSE.GVKLLATVLSQ...............
G7Q084_MACFA/349-397                 ............EEIWVLRKP.FA.G.GDRS--GSI....SGVAGSRGSGG-----.....HTLHAGSE.GIKLLATVLSQ...............
A0A2G9SMB7_LITCT/46-103              ............EEIWVLRKP.FA.G.GDRSSMGST....GSGASGRSSGSGQSANs...pHAIPASAE.GVKLLATVLSQ...............
A0A2D0SAV2_ICTPU/419-467             ............EDIWVLRSS.FT.-.GDRNSVGSA....GSVGSSRSAGSGQSTE....gNFTH----.-----------naqhqtst.......
A0A0R4IGS7_DANRE/415-451             .....vpttpth---------.--.-.---------....--------SPGVNTHGl..nvPGLHAQAE.GVKLLATVLSQ...............
I3N4E2_ICTTR/341-389                 ............EEIWVLRKP.SA.G.GDRS--GNL....SSVAGSRSSGA-----.....HALHAGSE.GVKLLATVLSQ...............
A0A2I4BGM4_9TELE/368-414             ............EDIWVLRKP.MA.G.GERS--GSV....GSLGSXRSSSSLQSSGn...tHVLTT---.-----------papsp..........
H2UA11_TAKRU/366-409                 .......sfdsm---------.--.G.GDRSSLGSS....SSVNSVRSSGSGQSAAs..apHILHAQ--.-----------ekpl...........
A0A2I4CHL0_9TELE/407-460             ...........q-DIWVLRSS.PT.-.GDRNSVGST....GSAGSSRSAGSGQSSE.....-SGHK---.-----------qngthnrhhhdtvk.
G3UHQ2_LOXAF/373-421                 ............EEIWVLRKP.FA.G.GDRS--SSL....SSVPGGRGSGG-----.....HVLHAGSE.GVKLLATVLSQ...............
A0A2K5NVJ1_CERAT/373-421             ............EEIWVLRKP.FA.G.GDRS--GSI....SGMAGSRGSGG-----.....HTLHPGSE.GIKLLATVLSQ...............
A0A218U7Z2_9PASE/376-434             ............EEIWVLRKP.FA.G.GDRSSLGST....GSVASARSSGSGQSAGs..gaHALHAGSE.GVKLLATVLSQ...............
A0A0Q3U620_AMAAE/20-78               ............EEIWVLRKP.FT.G.GDRSSLGST....GSVASARSSGSGQSAGs..gaHALHAGSE.GVKLLATVLSQ...............
H2UA08_TAKRU/344-402                 ............EEIWVLRKP.VA.G.GDRSSLGSS....SSVNSVRSSGSGQSAAs..apHILHAQAE.GVKLLATVLSQ...............
CSKI1_RAT/373-421                    ............EEIWVLRKP.FA.G.GDRS--GSL....SNVAGGRSTGG-----.....HALHAGAE.GVKLLATVLSQ...............
A0A0R4IIH7_DANRE/335-371             .....vpttpth---------.--.-.---------....--------SPGVNTHGl..nvPGLHAQAE.GVKLLATVLSQ...............
#=GC seq_cons                        ............EEIWVLRKP.hA.G.GDRS..GSs....uSVuuuRSSGSsp........HsLHAtuE.GVKLLATVLSQ...............
//
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