GenomeNet

Database: Pfam
Entry: CdiI_2
LinkDB: CdiI_2
Original site: CdiI_2 
#=GF ID   CdiI_2
#=GF AC   PF18593.2
#=GF DE   CdiI immunity protein
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF08174
#=GF GA   26.70 26.70;
#=GF TC   26.70 26.70;
#=GF NC   26.40 26.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   28398546
#=GF RT   The CDI toxin of Yersinia kristensenii is a novel bacterial
#=GF RT   member of the RNase A superfamily.
#=GF RA   Batot G, Michalska K, Ekberg G, Irimpan EM, Joachimiak G,
#=GF RA   Jedrzejczak R, Babnigg G, Hayes CS, Joachimiak A, Goulding CW;
#=GF RL   Nucleic Acids Res. 2017;45:5013-5025.
#=GF DR   INTERPRO; IPR041129;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Contact-dependent growth inhibition (CDI) is an important
#=GF CC   mechanism of inter-bacterial competition found in many
#=GF CC   Gram-negative pathogens. CDI+ cells express cell-surface CdiA
#=GF CC   proteins that bind neighboring bacteria and deliver C-terminal
#=GF CC   toxin domains (CdiA-CT) to inhibit target-cell growth. CDI+
#=GF CC   bacteria also produce CdiI immunity proteins, which specifically
#=GF CC   neutralize cognate CdiA-CT toxins to prevent self-inhibition.
#=GF CC   Structure analysis of CdiI immunity protein from Yersinia
#=GF CC   kristensenii shows that it is composed of eight alpha-helices
#=GF CC   packed together to form a nearly spherical structure with weak
#=GF CC   structural homology to a putative TetR family transcriptional
#=GF CC   repressor. The CdiI protein fits into the curved cavity of the
#=GF CC   CdiA-CTYkris toxin domain where it most likely neutralizes toxin
#=GF CC   activity by blocking access to RNA substrates [1]. This domain
#=GF CC   is mostly found in gammaproteobacteria.
#=GF SQ   243
#=GS A0A1C5ELV0_9ACTN/1-74     AC A0A1C5ELV0.1
#=GS A0A367EZX9_9ACTN/127-216  AC A0A367EZX9.1
#=GS T0QM06_PHOTE/4-94         AC T0QM06.1
#=GS A0A2N0H1P6_9ACTN/127-216  AC A0A2N0H1P6.1
#=GS W1J4V6_9GAMM/2-90         AC W1J4V6.1
#=GS A0A1X7J2J6_9BURK/6-95     AC A0A1X7J2J6.1
#=GS H5WTA4_9BURK/7-96         AC H5WTA4.1
#=GS A0A1K2FGK6_9ACTN/126-215  AC A0A1K2FGK6.1
#=GS A0A0Q5RGV7_9MICO/101-191  AC A0A0Q5RGV7.1
#=GS A0A1Q8IQD4_9BURK/5-94     AC A0A1Q8IQD4.1
#=GS A0A1W6B2S5_9GAMM/3-95     AC A0A1W6B2S5.1
#=GS A0A0S9PYK4_9ACTN/3-92     AC A0A0S9PYK4.1
#=GS A0A2I0FXT6_9GAMM/4-93     AC A0A2I0FXT6.1
#=GS A0A1H7W0R9_9BURK/105-192  AC A0A1H7W0R9.1
#=GS A0A0M0KF35_9BACI/7-92     AC A0A0M0KF35.1
#=GS D8MLC7_ERWBE/3-95         AC D8MLC7.1
#=GS T0QFI5_PHOTE/1-89         AC T0QFI5.1
#=GS A0A401YA29_9ACTN/2-90     AC A0A401YA29.1
#=GS F8JZ28_STREN/141-230      AC F8JZ28.1
#=GS A0A2D3UB74_STRC0/126-215  AC A0A2D3UB74.1
#=GS T0P833_PHOTE/105-152      AC T0P833.1
#=GS A0A2P2GPV6_9ACTN/121-210  AC A0A2P2GPV6.1
#=GS A0A100W1S9_9MYCO/17-105   AC A0A100W1S9.1
#=GS B6VMT9_PHOAA/1-89         AC B6VMT9.1
#=GS A0A2I0G1G7_9GAMM/3-90     AC A0A2I0G1G7.1
#=GS K9VIF6_9CYAN/4-95         AC K9VIF6.1
#=GS A0A1X7LZR3_9BURK/6-94     AC A0A1X7LZR3.1
#=GS A0A1D8G2B1_9ACTN/126-215  AC A0A1D8G2B1.1
#=GS Q5WJ54_BACSK/7-92         AC Q5WJ54.1
#=GS A0A2U9P1P7_STRAS/126-215  AC A0A2U9P1P7.1
#=GS A0A0K2AWX1_STRA7/126-215  AC A0A0K2AWX1.1
#=GS A0A2T1G5N9_9CYAN/4-95     AC A0A2T1G5N9.1
#=GS YXXE_BACSU/10-93          AC P40738.1
#=GS A0A1H7W0R9_9BURK/7-94     AC A0A1H7W0R9.1
#=GS A0A0Q8PJJ3_9BURK/7-99     AC A0A0Q8PJJ3.1
#=GS A0A0C1XKD4_9ACTN/126-215  AC A0A0C1XKD4.1
#=GS A0A1Q8IMU9_9BURK/6-93     AC A0A1Q8IMU9.1
#=GS A0A372M9T1_9ACTN/110-196  AC A0A372M9T1.1
#=GS A0A2X5A6N4_SERRU/4-95     AC A0A2X5A6N4.1
#=GS A0A2L0WJN1_9RHIZ/3-94     AC A0A2L0WJN1.1
#=GS F2RCJ6_STRVP/126-215      AC F2RCJ6.1
#=GS B5HJM5_STRE2/121-210      AC B5HJM5.1
#=GS A0A1B3W5I6_9GAMM/3-93     AC A0A1B3W5I6.1
#=GS A0A1H9UFC2_9ACTN/126-215  AC A0A1H9UFC2.1
#=GS F7NHZ5_9FIRM/4-89         AC F7NHZ5.1
#=GS D6KBN5_9ACTN/124-214      AC D6KBN5.1
#=GS T0P833_PHOTE/6-95         AC T0P833.1
#=GS A0A2W7FL58_9BURK/5-95     AC A0A2W7FL58.1
#=GS D5ZQQ6_STRV1/21-91        AC D5ZQQ6.1
#=GS A0A221NXM0_9ACTN/71-160   AC A0A221NXM0.1
#=GS A0A2G4F3L5_9CYAN/4-95     AC A0A2G4F3L5.1
#=GS A0A1Q8IYZ5_9BURK/7-63     AC A0A1Q8IYZ5.1
#=GS A0A161Y080_9BACI/10-93    AC A0A161Y080.1
#=GS A0A250V2T4_STROL/124-213  AC A0A250V2T4.1
#=GS A0A369UGB5_9GAMM/5-96     AC A0A369UGB5.1
#=GS A0A096AJQ3_9BURK/3-90     AC A0A096AJQ3.1
#=GS A0A1T4R7X7_9ACTN/1-88     AC A0A1T4R7X7.1
#=GS A0A317JWS6_9ACTN/2-93     AC A0A317JWS6.1
#=GS A0A443IF61_9GAMM/1-74     AC A0A443IF61.1
#=GS A0A240AUK1_SERFI/4-95     AC A0A240AUK1.1
#=GS A0A085JII1_9GAMM/3-95     AC A0A085JII1.1
#=GS A0A384L193_YERPE/2-93     AC A0A384L193.1
#=GS A0A150KL19_9BACI/9-93     AC A0A150KL19.1
#=GS A0A1A1YEP2_9MYCO/7-95     AC A0A1A1YEP2.1
#=GS A0A1Q8IMW5_9BURK/6-94     AC A0A1Q8IMW5.1
#=GS A0A1H8HS99_9BACL/3-88     AC A0A1H8HS99.1
#=GS A0A1C4SNJ4_9ACTN/126-215  AC A0A1C4SNJ4.1
#=GS A0A2T6BV91_9BACL/6-90     AC A0A2T6BV91.1
#=GS A0A2W7HDJ9_9BURK/104-193  AC A0A2W7HDJ9.1
#=GS T0PC91_PHOTE/4-94         AC T0PC91.1
#=GS A0A1Q8IMV5_9BURK/6-94     AC A0A1Q8IMV5.1
#=GS A0A0G3M450_9FLAO/6-94     AC A0A0G3M450.1
#=GS A0A1X7LZP2_9BURK/6-93     AC A0A1X7LZP2.1
#=GS A0A1B6Z5H0_9SPHN/15-105   AC A0A1B6Z5H0.1
#=GS A0A191ZJP2_9GAMM/4-93     AC A0A191ZJP2.1
#=GS A0A090VYC9_ESCVU/4-92     AC A0A090VYC9.1
#=GS B4V6N2_9ACTN/123-212      AC B4V6N2.1
#=GS A0A2W7FL58_9BURK/105-194  AC A0A2W7FL58.1
#=GS A0A1V3IXF7_9PAST/1-90     AC A0A1V3IXF7.1
#=GS E8UFW5_TAYEM/4-83         AC E8UFW5.1
#=GS A0A1V0Q178_9RHOB/3-92     AC A0A1V0Q178.1
#=GS A0A2M8W3M7_9MICO/1-91     AC A0A2M8W3M7.1
#=GS A0A235B1D4_9BACL/9-92     AC A0A235B1D4.1
#=GS A0A090UZY5_ESCVU/5-95     AC A0A090UZY5.1
#=GS D9WMD7_9ACTN/127-216      AC D9WMD7.1
#=GS A0A0F0GH21_9ACTN/126-215  AC A0A0F0GH21.1
#=GS A0A1J4P5H0_9ACTN/126-215  AC A0A1J4P5H0.1
#=GS A0A157SDL1_9BORD/5-94     AC A0A157SDL1.1
#=GS A0A1G9EEF4_9ACTN/126-215  AC A0A1G9EEF4.1
#=GS A0A1H7V2T5_9BURK/1-67     AC A0A1H7V2T5.1
#=GS A0A2D3U8B6_STRC0/123-203  AC A0A2D3U8B6.1
#=GS A0A085JCW9_9GAMM/4-88     AC A0A085JCW9.1
#=GS A0A2X5A255_SERRU/3-94     AC A0A2X5A255.1
#=GS C7JFE8_ACEP3/1-80         AC C7JFE8.1
#=GS C3BK79_9BACI/7-92         AC C3BK79.1
#=GS A0A1H0C6S3_9ACTN/134-219  AC A0A1H0C6S3.1
#=GS A0A2M8M214_9ACTN/127-215  AC A0A2M8M214.1
#=GS A0A1A5P2I8_9ACTN/126-215  AC A0A1A5P2I8.1
#=GS A0A1Q4ZNE7_9ACTN/127-216  AC A0A1Q4ZNE7.1
#=GS A0A142LJ04_9PROT/20-120   AC A0A142LJ04.1
#=GS A0A1B9ENI4_9ACTN/126-215  AC A0A1B9ENI4.1
#=GS A0A2N0IQT7_9ACTN/126-215  AC A0A2N0IQT7.1
#=GS A0A073KCQ9_9BACI/7-92     AC A0A073KCQ9.1
#=GS E3EIL0_PAEPS/17-86        AC E3EIL0.1
#=GS A0A1Q5N3X1_9ACTN/126-215  AC A0A1Q5N3X1.1
#=GS B7GM37_ANOFW/7-86         AC B7GM37.1
#=GS A0A0M1NUW1_9BACI/9-93     AC A0A0M1NUW1.1
#=GS A0A1A1XIG1_9MYCO/7-95     AC A0A1A1XIG1.1
#=GS A0A240ATD6_SERFI/2-91     AC A0A240ATD6.1
#=GS A0A1W6BB26_9GAMM/1-85     AC A0A1W6BB26.1
#=GS A0A0J7AQR8_9ACTN/90-164   AC A0A0J7AQR8.1
#=GS A0A401UYE9_9CELL/14-103   AC A0A401UYE9.1
#=GS A0A1I1L501_9BURK/5-91     AC A0A1I1L501.1
#=GS A0A384LPR9_YERPE/28-119   AC A0A384LPR9.1
#=GS A0A1M5WPI1_9ACTN/126-215  AC A0A1M5WPI1.1
#=GS A0A1X7M3Q6_9BURK/6-95     AC A0A1X7M3Q6.1
#=GS A0A1G8MN15_9BURK/3-91     AC A0A1G8MN15.1
#=GS A0A384I280_9ACTN/126-215  AC A0A384I280.1
#=GS A0A1M6CJ00_9BACT/1-81     AC A0A1M6CJ00.1
#=GS A0A1Q8IQE1_9BURK/6-95     AC A0A1Q8IQE1.1
#=GS A0A0G4JSP1_9GAMM/3-92     AC A0A0G4JSP1.1
#=GS A0A0Q7BNB1_9ACTN/8-95     AC A0A0Q7BNB1.1
#=GS A0A1I5NKY5_9RHIZ/4-95     AC A0A1I5NKY5.1
#=GS A0A1S2K5G1_9ACTN/126-215  AC A0A1S2K5G1.1
#=GS W0PEP9_9BURK/3-90         AC W0PEP9.1
#=GS A0A0A0M6N8_9GAMM/6-96     AC A0A0A0M6N8.1
#=GS A0A1B1ANU3_9ACTN/126-215  AC A0A1B1ANU3.1
#=GS A0A2M8LS03_9ACTN/121-210  AC A0A2M8LS03.1
#=GS S2XXL9_9ACTN/126-215      AC S2XXL9.1
#=GS E8UFW7_TAYEM/3-80         AC E8UFW7.1
#=GS A0A139VFR0_MYCPH/7-95     AC A0A139VFR0.1
#=GS A0A1B1WGC9_9MYCO/8-95     AC A0A1B1WGC9.1
#=GS A0A2W7G531_9BURK/1-86     AC A0A2W7G531.1
#=GS A0A1X7HBU0_9ACTN/126-215  AC A0A1X7HBU0.1
#=GS A0A1W6B7U8_9GAMM/12-103   AC A0A1W6B7U8.1
#=GS A0A2X5DTF3_SERRU/1-64     AC A0A2X5DTF3.1
#=GS A0A1G6TN17_9PROT/4-92     AC A0A1G6TN17.1
#=GS A0A1N7HB67_9ACTN/1-92     AC A0A1N7HB67.1
#=GS A0A1Q4ZNE4_9ACTN/126-215  AC A0A1Q4ZNE4.1
#=GS A0A1H5F4G2_9ACTN/126-215  AC A0A1H5F4G2.1
#=GS A0A0F5VBJ7_9GAMM/3-87     AC A0A0F5VBJ7.1
#=GS A0A150KKM4_9BACI/10-94    AC A0A150KKM4.1
#=GS A0A096ANB0_9BURK/4-91     AC A0A096ANB0.1
#=GS A0A0C2ARJ0_9ACTN/121-210  AC A0A0C2ARJ0.1
#=GS A0A3N4YRI9_9MICO/1-90     AC A0A3N4YRI9.1
#=GS A0A2M9E8G8_9GAMM/3-93     AC A0A2M9E8G8.1
#=GS A0A250VNG8_STROL/126-215  AC A0A250VNG8.1
#=GS A0A235B1F5_9BACL/1-81     AC A0A235B1F5.1
#=GS G2I424_KOMMN/15-99        AC G2I424.1
#=GS A0A1I5WHB0_9BURK/2-91     AC A0A1I5WHB0.1
#=GS A0A0A3JE71_9BACI/8-92     AC A0A0A3JE71.1
#=GS A0A240A7N2_SERFI/4-87     AC A0A240A7N2.1
#=GS A0A225D8R4_9BACT/1-90     AC A0A225D8R4.1
#=GS A0A1X7M3Q3_9BURK/5-94     AC A0A1X7M3Q3.1
#=GS A0A0Q8E2T4_9ACTN/5-88     AC A0A0Q8E2T4.1
#=GS A0A384KVM4_YERPE/5-91     AC A0A384KVM4.1
#=GS A0A1A1XID4_9MYCO/7-94     AC A0A1A1XID4.1
#=GS A0A3N0DQS6_9ACTN/1-92     AC A0A3N0DQS6.1
#=GS A0A1H7PR82_9BURK/6-95     AC A0A1H7PR82.1
#=GS A0A1X7JGD2_9BURK/5-94     AC A0A1X7JGD2.1
#=GS A0A0M8QPB1_9ACTN/126-215  AC A0A0M8QPB1.1
#=GS A0A0M2K571_9GAMM/2-71     AC A0A0M2K571.1
#=GS A0A1T4N1L0_ENTAG/3-95     AC A0A1T4N1L0.1
#=GS T0QFH9_PHOTE/1-99         AC T0QFH9.1
#=GS A1SN47_NOCSJ/2-89         AC A1SN47.1
#=GS A0A2P2GSN5_9ACTN/121-210  AC A0A2P2GSN5.1
#=GS A0A095YT31_9BURK/3-90     AC A0A095YT31.1
#=GS A0A095TDW0_9GAMM/12-96    AC A0A095TDW0.1
#=GS A0A095T6M4_9GAMM/3-95     AC A0A095T6M4.1
#=GS A0A3N6FMT9_9ACTN/126-215  AC A0A3N6FMT9.1
#=GS A0A1H7V2T8_9BURK/1-52     AC A0A1H7V2T8.1
#=GS A0A090V3W9_ESCVU/3-91     AC A0A090V3W9.1
#=GS A0A3L8K1B4_9ACTN/5-94     AC A0A3L8K1B4.1
#=GS C8WSS6_ALIAD/5-87         AC C8WSS6.1
#=GS D0LT08_HALO1/7-95         AC D0LT08.1
#=GS A0A1I0VWI4_9ACTN/1-90     AC A0A1I0VWI4.1
#=GS A0A0M2K7Q1_9GAMM/5-95     AC A0A0M2K7Q1.1
#=GS A0A372JQ97_9ACTN/118-205  AC A0A372JQ97.1
#=GS A0A0H1AUJ1_9GAMM/4-94     AC A0A0H1AUJ1.1
#=GS A0A2P6MMF7_9MYCE/188-279  AC A0A2P6MMF7.1
#=GS A0A1H0N4A0_9RHIZ/6-95     AC A0A1H0N4A0.1
#=GS A0A2W7FL58_9BURK/206-293  AC A0A2W7FL58.1
#=GS Q7N7X3_PHOLL/4-94         AC Q7N7X3.1
#=GS A0A401FW53_9DELT/6-95     AC A0A401FW53.1
#=GS A0A347UHP4_9RHOB/4-95     AC A0A347UHP4.1
#=GS A0A071MA46_9ENTR/3-93     AC A0A071MA46.1
#=GS A0A1E5MIE7_9MICO/7-96     AC A0A1E5MIE7.1
#=GS A0A090IV48_9BACI/10-94    AC A0A090IV48.1
#=GS I9C8J4_9SPHN/6-95         AC I9C8J4.1
#=GS E3BHJ9_9VIBR/4-94         AC E3BHJ9.1
#=GS A0A2R4T4B1_9ACTN/127-216  AC A0A2R4T4B1.1
#=GS A0A448HYC7_MYCCI/7-94     AC A0A448HYC7.1
#=GS W9AVF3_9MYCO/11-101       AC W9AVF3.1
#=GS A0A1T4P3B3_ENTAG/5-95     AC A0A1T4P3B3.1
#=GS A0A197SVK1_9ACTN/126-215  AC A0A197SVK1.1
#=GS A0A090V5Y5_ESCVU/3-95     AC A0A090V5Y5.1
#=GS A0A0H4BW89_9ACTN/126-215  AC A0A0H4BW89.1
#=GS A0A117PVW6_9ACTN/126-215  AC A0A117PVW6.1
#=GS A0A290XAK9_9GAMM/3-92     AC A0A290XAK9.1
#=GS A0A235F7G5_9BACI/9-93     AC A0A235F7G5.1
#=GS A0A1A1XIL0_9MYCO/7-95     AC A0A1A1XIL0.1
#=GS T0QM10_PHOTE/4-65         AC T0QM10.1
#=GS A0A1J4Q916_9ACTN/126-215  AC A0A1J4Q916.1
#=GS A0A143PW55_9BACT/8-89     AC A0A143PW55.1
#=GS I8ANQ6_9BACI/7-92         AC I8ANQ6.1
#=GS Q82D76_STRAW/11-92        AC Q82D76.1
#=GS A0A1C0V2T4_9CYAN/5-96     AC A0A1C0V2T4.1
#=GS A0A0H2M7Z4_VARPD/3-91     AC A0A0H2M7Z4.1
#=GS A0A1W6B7U4_9GAMM/12-104   AC A0A1W6B7U4.1
#=GS A0A101UA37_9ACTN/13-93    AC A0A101UA37.1
#=GS A0A427K6X9_9GAMM/4-89     AC A0A427K6X9.1
#=GS K4R7S7_STRDJ/12-101       AC K4R7S7.1
#=GS A0A085JCW8_9GAMM/3-91     AC A0A085JCW8.1
#=GS A0A1X7J1H3_9BURK/6-95     AC A0A1X7J1H3.1
#=GS A0A090UYU1_ESCVU/7-96     AC A0A090UYU1.1
#=GS A0A1E5MIE4_9MICO/11-101   AC A0A1E5MIE4.1
#=GS A0A1T4R885_9ACTN/1-88     AC A0A1T4R885.1
#=GS A0A2W7HDJ9_9BURK/5-94     AC A0A2W7HDJ9.1
#=GS A0A250KRE4_9GAMM/4-91     AC A0A250KRE4.1
#=GS A0A140NNF7_PROSM/2-90     AC A0A140NNF7.1
#=GS A0A427K4E5_9GAMM/7-96     AC A0A427K4E5.1
#=GS A0A1X7M107_9BURK/6-94     AC A0A1X7M107.1
#=GS B9JU67_AGRVS/1-74         AC B9JU67.1
#=GS A0A2W4CFV7_9RHIZ/6-95     AC A0A2W4CFV7.1
#=GS A0A085JAZ1_9GAMM/7-96     AC A0A085JAZ1.1
#=GS A0A0M8TYF9_9ACTN/108-197  AC A0A0M8TYF9.1
#=GS A0A1K2FKZ4_9ACTN/128-217  AC A0A1K2FKZ4.1
#=GS A0A1W6B7T3_9GAMM/16-104   AC A0A1W6B7T3.1
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A0A0M2K571_9GAMM/2-71                ........i-YSYLDHLMGAYFN.QD.YDL.S.GET......INEVVQCYI..DSEG.P....DKSSGLASDCMN.FLKEVD-..--..-----...........----.------..-.--.-.--------------vegkfgrdadllimm...........................
A0A1T4N1L0_ENTAG/3-95                ........k-FHFPDQLIFGYFN.QD.ADI.I.NDGe...dtIKGIVRLFK..KSVP.D....WMLNDLVEEVDD.FISAYGG..N-..VEEEF...........RKRY.GFDFAP..E.LW.E.TTAHEFLMTVRQ--is........................................
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A0A1I0VWI4_9ACTN/1-90                ........m--EDLRQLMAAYFH.QD.WWA.E.YDG.....lWESAVDDFA..RRE-.P....DRVAGASDQIHA.LLDEDEA..DE.aLGQTL...........-DDL.GNFYDA..G.HA.P.GANRAWLQQVGEQL..........................................
A0A0M2K7Q1_9GAMM/5-95                ......ntf---GLDSLIAVYFG.QD.YDL.F.GSGe....sVSAQIDAWI..ADTP.A....AFREGMLGDIEQ.FCRECDD..--..VDEDF...........EARY.GDDFST..E.LW.D.TTPGDFFELLREK-i.........................................
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A0A0H1AUJ1_9GAMM/4-94                ........a-YPTLENFFAGYFH.QD.WAA.E.HDA......PEAVVAYYR..DSEN.P....DQVSHARAEAEA.LLGEQLD..EA.aLGARI...........-TAL.GCEYDP..T.RD.G.ATWRGWLQRLAQDL..........................................
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A0A1H0N4A0_9RHIZ/6-95                ......dlf---ELDQLIRAYLH.QD.MEL.E.AAS......VPEAIGRYA..RLND.E....RTKASLAAAMDL.FLHRFH-..ND..LHAEF...........ARRY.RYDFMP..D.EL.G.LDVPGFFQMVRAI-l.........................................
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A0A1E5MIE7_9MICO/7-96                .......gv--PSFANLMGGAFN.QD.WRD.E.WDT......AAEVVTSVL..GER-.T....DQLRNLLKDLRR.IVRVRSD..DD..IDSLL...........-FSL.GSGFSP..EtDW.G.MSPKGWVQDLEVRL..........................................
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I9C8J4_9SPHN/6-95                    ........p-FRFLTAMMGHCFH.QD.MDL.E.AET......VPEAVALYV..RGLT.G....EAGRALQTDIEN.FQQQHAD..D-..PDAPF...........LRAF.GDDLDP..R.EV.G.LSVSDFLRMVEA--lv........................................
E3BHJ9_9VIBR/4-94                    .........NFNCIRYFISGYFH.QD.WDI.Y.GST......DKDVIAYFV..NKEP.L....DQVNTLISELEN.LLELDMD..NE..TADII...........LKES.GCGYYF..Q.AD.G.LNAMDWFSRIEG--ll........................................
A0A2R4T4B1_9ACTN/127-216             .........RFPELGQFLGGWFS.QD.MPD.E.FGD......HDSAVRDYG..STAD.R....TLVARLVGEVRE.LLALGLE..EV..DYALA...........VSEL.GMEVDP..P.-T.P.HTPGAWLALVADRI..........................................
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A0A1T4P3B3_ENTAG/5-95                .......ki--AGLDSLIAIYFG.QD.YDL.F.GSGe....sVDAQINAWI..ADST.P....ASRHGLIGDIEQ.FMRETD-..-N..LEQDF...........ESCY.GAEFST..D.LW.E.TTPAEFLKLLKQK-v.........................................
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A0A090V5Y5_ESCVU/3-95                .........NFHFLDQLIFGYFN.QD.ADI.I.NDGe...dtIEGIVRLFK..KSSP.G....WMLKDLIEEIDD.FISAYGD..D-..VEGEF...........KNRY.DFDFSP..D.LW.E.TTAYQFLMTVRQ--ic........................................
A0A0H4BW89_9ACTN/126-215             .........RFPELGQFLGGWFS.QD.MPD.E.FGG......HDAAVDDYA..ATTD.R....QLVAQLVGEVRG.LLALGLQ..ES..EYAVG...........AAEL.GMEVEP..P.-D.R.LTVSGWLALVAARL..........................................
A0A117PVW6_9ACTN/126-215             .........RFPELGQFLGGWFS.QD.MPD.E.FTD......HDAAVDDYR..ATTD.P....QLVARLAGELHE.LLVLDLD..ES..DYALA...........VAEL.GMEVDA..P.-A.P.YSPSGWLARVAEQL..........................................
A0A290XAK9_9GAMM/3-92                ........d-YPTLENFFAAYFH.QD.WAV.E.HGS......ADEVIAYYR..SSES.P....DQVARARGEAQA.LLDDGLD..DA.aLGARI...........-MAL.GSEYDP..T.RD.G.ATWRSLLQRLAA--a.........................................
A0A235F7G5_9BACI/9-93                .....npvf------QFLAGTFH.QD.I--.-.-DS......PEEALLELL..QDES.N....EYLEEAIVFLTD.FINSEYT..IV..EKNKF...........IEEC.AEGIYF..P.AL.G.LEPLQWLKNVVQE-i.........................................
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T0QM10_PHOTE/4-65                    .........QYPFLDILIYAYFN.QD.CTI.I.YGS.....eLDDVIDAFF..SNTS.S....KMKREVIKEINS.FIHNSED..--..VE---...........----.------..-.--.-.--------------kki.......................................
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A0A143PW55_9BACT/8-89                .........RWPHLASLFGGYLH.QD.FTA.E.YGS......APRAVQAAL..TAVE.A....DKGREVSAEWRR.FLNLTQG..MD..LQAR-...........----.------..-.--.-.--------------arllrelaggswapgderef......................
I8ANQ6_9BACI/7-92                    .......yl--EELEDFLGGTFH.QD.I--.-.-RS......PEEALDEFL..NEAS.L....ECFISTIKGCEM.FLNSHLT..KQ..KKEHI...........IQNN.VEVYFP..A.-I.A.LNPLEWLNKLVEK-m.........................................
Q82D76_STRAW/11-92                   .....aswv---------MSFFH.QD.WTY.D.GPT......AADVVAKHL..SESA.D....ELALAVRRDART.LLDNLPS..ET..LEVL-...........-WNA.GAQYMA..S.FE.G.TSGSEWTR------tvig......................................
A0A1C0V2T4_9CYAN/5-96                .........QFPALAQFCSAYFH.QD.WDL.E.APD......ALGIIRNYL..KDES.I....SQVQQTIKEIEQ.LLSLNLE..TE.kLKNFL...........ESDL.KCYYNP..R.VY.N.ISHSDWLLWVQ---isl.......................................
A0A0H2M7Z4_VARPD/3-91                .........RYELIENLTEVYFG.QD.YDY.F.GET......GAEIMAEYR..KACT.P....AELEALRVEIVD.FMRSHPD..--..LETDF...........PRRF.ERPAQP..E.DF.G.STIREFLESVLAA-l.........................................
A0A1W6B7U4_9GAMM/12-104              .........KYSSLGSMIRVFFSpQD.CDS.F.GET......IEVITQSYQ..EVFPgK....EAQQALKTQIKE.MLETTDD..VD..LSKRM...........SLIT.EEEFNP..V.KW.G.ETWRSFLLRVL---avl.......................................
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A0A427K6X9_9GAMM/4-89                ........s-YPRLKKLMMTYIN.MD.AEE.I.TGEd....tLEGMLSYYA..TRVS.G....KAIRELLAEVSV.FRQAYQD..D-..LDTAF...........LRRF.DYGAD-..-.--.-.--------------ipdvasffqplsk.............................
K4R7S7_STRDJ/12-101                  .........RFLALSQLLGAYFC.QD.FPD.W.YGS......WEEAIDDYL..GDMD.G....EEAGRAAEEITQ.ILAIVTS..DQ.eLKQAT...........-HIL.GLELLP..P.-R.G.MTLRRWLEGMRHR-i.........................................
A0A085JCW8_9GAMM/3-91                ........s-TTHIDIMIEGSLN.QD.FDY.I.TGTe....tIDDAIDIYT..KGLA.T....QDHQDLKKEVLA.FLCSDDS..T-..IKSEF...........KTRY.FNYFSP..E.-E.-.--------------gkglllrvlegle.............................
A0A1X7J1H3_9BURK/6-95                ........l-YPNLNFLIHGYFN.ED.FDL.W.GNN......VQEIVSCFK..KESD.K....TLHKLVMDEIDR.FKCDCSA..N-..LDEHF...........EEMY.GFYVDP..E.AW.G.YTAASFLDEVKRL-l.........................................
A0A090UYU1_ESCVU/7-96                .........KTCELDNLVTIYFG.QD.CDI.F.DENc....dFDNLLNEYL..STSS.A....FSLRMLLANLIE.LNAQDD-..--..RCEVL...........LARY.NGEFAP..E.RW.D.MSAQDWLDIVNSRL..........................................
A0A1E5MIE4_9MICO/11-101              .........EYPLVRNLLGAIFN.QD.WRE.D.HDC......VEEVYEDLL..DGEP.R....HARLARAEQIEA.FVANRSE..DE..VDDVF...........-RAS.GTGLRP..R.SDlG.VSSREWLLAVVQRL..........................................
A0A1T4R885_9ACTN/1-88                ........m-YEYLRKFFAGGMH.QD.WDL.D.GDS......LEEIFRKRH..VN-A.L....DESRRILQEIEM.MLSSDLS..EE.eIDHLV...........TIQW.RSGYEP..D.ED.T.ETWRGVL-------rdmi......................................
A0A2W7HDJ9_9BURK/5-94                .........RYPRMYQFFGAYFN.QD.FDM.W.GNT......IPEIVSCYA..SNCP.W....ASHIELINEIDA.FVREHPT..D-..LDAAF...........AKDY.GAGFDP..K.LW.G.HTVRSFLEELKG--ll........................................
A0A250KRE4_9GAMM/4-91                ........s-FPHLDSFIHIYFG.QD.FDL.I.ADN......MEDLVADFA..RSSS.P....DDIRALRADIAR.FFQQAD-..--..VESAF...........KQVY.ENDIDP..H.AW.H.HTADSFLRRVD---fll.......................................
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A0A427K4E5_9GAMM/7-96                .........KTCELDNLVIIYFG.QD.CDI.F.DEEc....dFDNLLNEYL..NTSS.E....FSLRMLLANLIE.LNAQND-..--..RCEVL...........LSRY.NGEFAP..D.RW.E.MTAQEWLDIVNRRL..........................................
A0A1X7M107_9BURK/6-94                ........l-YPEMDHIFAIYFG.QD.FDL.F.GET......VPEIVACYK..KDS-.P....YHYEKLLRELGA.FRQEHPN..D-..LDSAF...........EKDY.GRDFDP..K.LW.G.YTTASFFDELKRL-l.........................................
B9JU67_AGRVS/1-74                    .........--------------.--.MDL.E.YQS......VPEAIAGYA..RLTE.D....IRKQQLVQEMHE.FLHRYHN..D-..VEGEF...........SKRY.WFDFSP..Q.TL.G.QTVPEFFDMVRD--iv........................................
A0A2W4CFV7_9RHIZ/6-95                ........t-FPALADMMGSCFH.QD.MDL.E.AET......VPEAVALYA..RGLS.A....DAGKALQAEIDS.FRQQHPA..D-..LDEAF...........LQAF.GDDLDP..S.DA.G.FGTEEFLRMVD---avv.......................................
A0A085JAZ1_9GAMM/7-96                .......ks--CEMDNLVVAYYG.QD.CDI.F.DPGc....nFDNLLNEYM..ATSS.P....FHLRMLLANIQE.FEQEPM-..--..GLKVF...........TVRY.SVDFAP..D.RW.N.MTAAEWLSAVKMR-v.........................................
A0A0M8TYF9_9ACTN/108-197             .........RFPELGQFLGGWFS.QD.MPD.E.FDD......HDAAVGDYR..TSTD.P....HVVARLIGELHE.LLALDLD..ES..DYALA...........VAEL.GMEVDP..P.-A.P.YSPGGWLALVADRL..........................................
A0A1K2FKZ4_9ACTN/128-217             .........QFPELRHLLAAYFH.QD.FSR.F.YQS......HAEALDDYF..SGTS.P....EDIAQAAGEIES.LLALVDS..EE..ELDRV...........TEIL.GLQVYP..P.-D.G.VPLRQWLADIREI-v.........................................
A0A1W6B7T3_9GAMM/16-104              ........r-YAFTGILLQAYFF.DD.FDI.Y.GDT......VEEIVASYR..ECY-.K....DNYNLLRAEVEE.LLLLPDS..E-..LAERM...........ALLA.ENQFDP..E.LW.G.ETWRSFLLRVLA--al........................................
T0P0I9_PHOTE/4-94                    .........QYPFLDILMYAYFN.QD.FDV.I.SGP.....eLDDVINDFL..NDAS.Q....GMKKGLIEEIND.LIDSSED..--..VENTF...........DYYYhDADVLP..E.GW.G.MTALEFLTHVSNK-s.........................................
A0A2W7HDJ9_9BURK/205-292             .........RYPEMGLAFGVYFG.QD.CHL.F.GDT......IPEIVTSYK..NDC-.-....PEYCNLPRELDA.FAAEHPD..D-..LDAAF...........EEDF.GSGFDP..Q.FW.G.YTTASFFEEIKRL-l.........................................
A0A1X7E7J1_9BACI/8-92                ........l--EELEDFLAGTFH.QD.I--.-.-SS......PEEALDEFI..EEAS.K....ECLLFTIKYCEE.FLSSELT..EQ..EKENI...........IQNN.ADIYFP..A.-I.E.LTPLQWLNQLVKK-i.........................................
A0A0K9XAF0_9ACTN/126-215             .........RFPELGQLLGGWFS.QD.MPD.E.FGD......HDAALADYA..GSTE.A....ALVARLVGEVHE.LLALRLA..ES..DTVLA...........VAEL.GMEVEP..P.-A.P.YSVSEWLAAVAERL..........................................
A0A160NZK7_STRLU/41-131              .........RFPETAQLLGGWFS.QD.IVD.E.FPD......HDAAVSDYA..TTTH.P....QLVARLVGELHE.LLALPCL..DE.gDYALA...........AAEL.GMEVGP..P.-E.P.FSHGAWFQSVATAL..........................................
A0A0N0XKM8_9NEIS/5-96                ........n-IEALGQLLGCYFH.QD.WTD.E.FDS......DEAAFQVIV..DSEP.K....ERLLAGVKEIDA.LLAASLP..ED.eLRSLM...........AESA.GCYFDP..G.SE.G.LTYEQWLKRARQK-f.........................................
C5ABE2_BURGB/6-95                    .........RYPELSNFIKNYFG.ED.FDL.W.GNT......IEEIFALYK..SEND.I....SARSQLGRDIDA.FRCDNSS..D-..LDASF...........KALY.GLFFNP..V.SW.N.HTTASFLDELKRL-l.........................................
A0A495NXT1_9ACTN/1-83                .........--------MSAYFH.QD.FKD.E.FDG.....rWESNVDDFI..RRS-.P....DQVADAADQALD.LLRECGT..DD.gLVTAL...........-DRL.GNYRHA..G.DQ.P.DAYASWLRQVVARL..........................................
A0A2M9JUV3_9ACTN/126-215             .........RFPEAAQFLGGWFS.QD.MPD.E.FED......HDAATRDYI..TTTD.L....HLKARLAGELHE.LLALPLD..ES.dYAQGL...........-TEL.GMEVDP..E.-T.P.YSPSGWLARVAEQM..........................................
A0A0Q4JFS4_9SPHN/15-105              .........RWPLLSNLMVCYFN.ED.FDL.L.YGS......LDGAVAASA..KDGS.L....DHRQAILKEWRD.WNSSVSA..AS.dLRPEL...........KKCF.SIAV--..-.--.-.--------------rfrnpidarhlmdsihdsl.......................
A0A1V1YPP7_9ACTN/126-215             .........RFPELGQFLGGWFS.QD.MPD.E.FND......HDAAIDDYR..TSTD.P....HLVARLVGELHE.LLTLDLD..ES..DYALA...........VAEL.GMEVDP..P.-A.P.YSPRGWLALVADRL..........................................
A0A0N1GPL6_9ACTN/126-215             .........RFPELGQFLGGWFS.QD.MPD.E.FDD......HDAAVDDYR..TTTD.R....HLVARLVGELRE.LLALSLD..ES..DYAVA...........VAEL.GMEVDP..P.-T.P.YSPSGWLALTAERL..........................................
A0A0Q5R595_9ACTN/44-135              .......av--NYLEQLVKGYLH.ED.FDL.Y.GDE......-WGALAVFV..SEYGgT....VAVENLVSDIDD.LLSAAGG..DD.gKIADQ...........LRAW.GIGIVP..S.PE.E.ETYRGWLGEVRKR-a.........................................
A0A1V1W324_9ACTN/4-90                .......es---ALEHLIGAYLN.QD.QSL.V.YPD......LMAGVDDFA..RDE-.P....DLAAALPSEIDD.VLASHMS..EA.dLVALM...........-RRL.GAGFMP..G.--.E.GGYRGRLTEIAD--rv........................................
Q5WJ62_BACSK/9-93                    .....epvf------QFLAGTFH.QD.I--.-.-DS......PEEALQELL..TEES.K....EYLEFAIIFLTD.FIESEYS..DI..EKNEY...........IQSC.ADGVYF..P.AT.G.LEPLQWLYQVIEQ-i.........................................
#=GC seq_cons                        ..........astLtphluuaFp.QD.hsh...hss......hcpslssYh..psss.s....phltpLhpElcp.hlstphs..-t..hptth............pph.uhphsP..t..h.s.hostpaLtpltp..h.........................................
//
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