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Database: Pfam
Entry: Cloacin
LinkDB: Cloacin
Original site: Cloacin 
#=GF ID   Cloacin
#=GF AC   PF03515.15
#=GF DE   Colicin-like bacteriocin tRNase domain
#=GF AU   Griffiths-Jones SR;0000-0001-6043-807X
#=GF SE   PRINTS
#=GF GA   25.00 25.00;
#=GF TC   52.30 51.70;
#=GF NC   21.60 21.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Colicin
#=GF RN   [1]
#=GF RM   12423786
#=GF RT   The modes of action of colicins E5 and D, and related cytotoxic
#=GF RT   tRNases.
#=GF RA   Masaki H, Ogawa T;
#=GF RL   Biochimie. 2002;84:433-438.
#=GF RN   [2]
#=GF RM   11741540
#=GF RT   Crystal structure of colicin E3: implications for cell entry and
#=GF RT   ribosome inactivation.
#=GF RA   Soelaiman S, Jakes K, Wu N, Li C, Shoham M;
#=GF RL   Mol Cell. 2001;8:1053-1062.
#=GF DR   INTERPRO; IPR016128;
#=GF DR   SCOP; 1jch; fa;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   The C-terminal region of colicin-like bacteriocins is either a
#=GF CC   pore-forming or an endonuclease-like domain. Cloacin and Pyocins
#=GF CC   have similar structures and activities to the colicins from E
#=GF CC   coli and the klebicins from Klebsiella spp. Colicins E5 and D
#=GF CC   cleave the anticodon loops of distinct tRNAs of Escherichia coli
#=GF CC   both in vivo and in vitro [1]. The full-length molecule has an
#=GF CC   N-terminal translocation domain and a middle, double
#=GF CC   alpha-helical region which is receptor-binding [2].
#=GF SQ   7
#=GS D3VLI7_XENNA/2-324      AC D3VLI7.1
#=GS A0A378QE36_KLEPR/1-319  AC A0A378QE36.1
#=GS A0A1X7AS71_9GAMM/1-108  AC A0A1X7AS71.1
#=GS A0A1B7K407_9GAMM/2-297  AC A0A1B7K407.1
#=GS A0A1V0M448_9GAMM/1-345  AC A0A1V0M448.1
#=GS A8ARS8_CITK8/1-223      AC A8ARS8.1
#=GS A0A1X1CU66_9GAMM/1-103  AC A0A1X1CU66.1
D3VLI7_XENNA/2-324                 ..................................cpiyg-------...-DGTDWSSEKGGYYEKPGDDdrh...kndGNKDRND..SGSSSGGSSsv...dlSQYPEAMAIifpyfaAVPSPIFPINGVLGVTINTGFIDTGLINL-----GnfinKAKPmanrlaqqaaanisgiarvgvFANPIVGIGIGSLWPGSIATDQEVRdalekklk..........................enggiikleHGYIVSTLPVDQV..SSVPAKKIRENKKIVAETVVTPVIDEKEQ.KRKAAITKSRTQIPVIKAEPTNRPNVYSASVVPG.MKPMQIKVDNT---NQAVPKNISKAnpipnvEIFTSAPV--...---NDTHHAFIDFGEK--HDLIYISVSKIPTVAEEKEQIEESKKNKQKW-l
A0A378QE36_KLEPR/1-319             msggdgrgpgnsglghnggqasgnvngtsgkggpssggg------Td.pNSGPGWGTTHTPNGDI---HnynpgefghGGNKPGG..NGGNSGNHRgss.ggrQSSATAMAF......GLPALATPGSGGLALAVSGDALSAAVADVLAALKG....---P.....................FRFGLWGIAIYGVLPSEIAKDDPKM...........................................MSKIMTSLPADAV..TETPASTLPLDQATVRVRQRVVDVVKDER.QHIAVVAGRPMSVPVVDAKPTKRPGVFSVSI-PG.LPSLQVSVPKGVPTAKAPPKGIVAE......KG-DSRPAGF...TAGGNSREAVIRFPKETGQKPVYVSVTDVLTPAQVKQRQEEEKRRQQAWD.
A0A1X7AS71_9GAMM/1-108             .......................................-------...--------------------.........-------..---------.......---------......-----------------------------------....----.....................-------------------------...........................................-------------..-----------------------------.----------MSVPVVDAKPTERPGVFTASI-PG.APVLNISVNNSTPAVQTLSPGVTNN......TDKDVRPAGF...TQGGNTRDAVIRFPKDSGHNAVYVSVSDVLSPDQVKQRQDEENRRQQEWD.
A0A1B7K407_9GAMM/2-297             ........................vngdsndsmtvsgss-------...--------DNGGR-GTGPE-.........GNGDSGGsyGGRARAVNF.......SKTPEKQTFvnpyllTIPANLAIIEGTWGVTINTTTLTSPLGRL-ASLLE....SSLP.....................MAGRLVGIA-GALLPTRIEPDTIDPafrehqrqla.......................nlvtnqklhsQTYALTALPVSIV..TDIPAKDIS-RQKTVSVKIAVEQVVSPEKnKVTQAIIKSPQTINVVKAKKTERTGVYSVDIAPG.KPALQIGLSDKKP-SKSFKTPSYDN......VKPESVIS--...STTSETYQGIVDFGDD--HAPIYISISKSLTVEEEKKAIEDAKQKEQEY-l
A0A1V0M448_9GAMM/1-345             ..........msggdgighnssssgginggptgfggdgr---NNGNaaySDHSGWSSENNGW-SNGNWG.........-GSSGPD.gSNSGNSGGSgrwggkqAANSSRYAV......ADLRLVKPGYPVAAFSIGGTINATVCTKV------....PDNP.....................FN--NWGDYIDNVKPYAAHLARATRntpvgkvasllmsledgrkeyaaklqqqmldearkeaakvnvsDLFHVTTLPVAEIlaASISMERIRELGKVLTKVVTQPVVDTKNQ.QRQIAITRQPTEVRVVKAEKTSKPNVYSAQVIAG.MKPMQITVDNSSSLSQ-----LNKT......QVNTAPEVGIfspTAADDTHHAILDFDGK--HDPIYISVSKVPTEAEEKAQLEATKKREQEW-l
A8ARS8_CITK8/1-223                 .......................................-------...--------------------.........-------..---------.......------MAF......GLPALATPGAEGLALSVSGDALSAAVADVLAALKG....---P.....................FKFGLWGIAIYGVLPSEIAKDDPKM...........................................MSKIVTSLPADTV..TETPVSSLPLDQATVSVTKRVADIVKDER.QHIAVVTGRPMSVPVVDAKPTKRPGVFSVSI-PG.LPSLQVSVPKGVPAAKAPPKGIIAE......KG-DSRPAGF...TAGGNSREAVIRFPKESGQKPVYVSVTDVLTPAQVKQRLEEEKRRQQAWD.
A0A1X1CU66_9GAMM/1-103             ......................................m-------...--------------------.........-------..---------.......---------......-----------------------------------....----.....................-------------------------...........................................-------------..-----------------------------.-----------------AKATKADGNWDAGWQPGsLGFLELTVVNK--PHQHPFEGRLGN.....lAELPLRPAGS...TVGAMTNDFVLWFPMGSNLEPLYVAFTTILPAGPLKNRADQQAAAQTKI-d
#=GC seq_cons                      ..............................................................................................................sh......s..t.hh.h..shuhslsssh.ssshhpl.............P.....................ht...hG.h..slhP.tht.sp................................................hhhosLPss.l..sphshppl...tthlt.h.h...lsp.pp.ph..slhtp.hplsVVcAKsTcRPGVaSsul.PG.hssLQloVsss.s.sps..pslhss......pt.sutPuG....TsuusT+cAllcFscc..pcPlYlSVoclLTsup.KpphE-pK++pQcW..
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