#=GF ID CoV_NSP2_N
#=GF AC PF19211.5
#=GF DE Coronavirus replicase NSP2, N-terminal
#=GF PI Corona_NS2_N;
#=GF AU Bateman A;0000-0002-6982-4660
#=GF AU Chuguransky S;0000-0002-0520-0736
#=GF SE Bateman A
#=GF GA 29.70 29.70;
#=GF TC 42.10 35.20;
#=GF NC 26.10 24.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 81514348 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 16227261
#=GF RT The nsp2 replicase proteins of murine hepatitis virus and severe
#=GF RT acute respiratory syndrome coronavirus are dispensable for viral
#=GF RT replication.
#=GF RA Graham RL, Sims AC, Brockway SM, Baric RS, Denison MR;
#=GF RL J Virol. 2005;79:13399-13411.
#=GF RN [2]
#=GF RM 34398430
#=GF RT Structure and Function of N-Terminal Zinc Finger Domain of
#=GF RT SARS-CoV-2 NSP2.
#=GF RA Ma J, Chen Y, Wu W, Chen Z;
#=GF RL Virol Sin. 2021;36:1104-1112.
#=GF RN [3]
#=GF RM 34159380
#=GF RT Nsp2 has the potential to be a drug target revealed by global
#=GF RT identification of SARS-CoV-2 Nsp2-interacting proteins.
#=GF RA Zheng YX, Wang L, Kong WS, Chen H, Wang XN, Meng Q, Zhang HN,
#=GF RA Guo SJ, Jiang HW, Tao SC;
#=GF RL Acta Biochim Biophys Sin (Shanghai). 2021;53:1134-1141.
#=GF DR INTERPRO; IPR043615;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This entry corresponds to the N-terminal region of coronavirus
#=GF CC non-structural protein 2. NSP2 is encoded by ORF1a/1ab and
#=GF CC proteolytically released from the pp1a/1ab polyprotein.
#=GF CC Viral-host protein interaction studies in SARS-CoV and
#=GF CC SARS_CoV-2 found that this protein could interact with several
#=GF CC host proteins including prohibitin 1 (PHB1) and PHB2, which are
#=GF CC implicated in a number of cellular functions, including cellular
#=GF CC migration, differentiation and apoptosis [2,3]. NSP2 structure
#=GF CC from SARS-CoV-2 has been recently solved and revealed that it
#=GF CC has three zinc fingers, covered in this entry, which may be
#=GF CC involved in binding nucleic acids and regulating intracellular
#=GF CC signalling pathways [2].
#=GF SQ 84
#=GS D9J202_9ALPC/111-312 AC D9J202.1
#=GS R1A_SARS2/182-423 AC P0DTC1.1
#=GS A0A096XNJ3_9ALPC/114-207 AC A0A096XNJ3.2
#=GS R1A_BCHK5/196-441 AC P0C6T5.1
#=GS E0ZN35_BCHK9/191-395 AC E0ZN35.1
#=GS A0A023YA54_MERS/196-445 AC A0A023YA54.1
#=GS R1A_CVPPU/110-310 AC P0C6V2.1
#=GS U5LR11_9BETC/201-450 AC U5LR11.1
#=GS C6GHB6_9ALPC/110-310 AC C6GHB6.1
#=GS A0A060A8I5_9ALPC/111-316 AC A0A060A8I5.1
#=GS S5PWH2_MERS/194-443 AC S5PWH2.3
#=GS A0A240FW17_9ALPC/111-292 AC A0A240FW17.1
#=GS E3W5F5_9ALPC/110-310 AC E3W5F5.1
#=GS B0LJQ9_9ALPC/110-310 AC B0LJQ9.1
#=GS B0LJR0_9ALPC/110-310 AC B0LJR0.1
#=GS A0A075Q443_MERS/194-443 AC A0A075Q443.1
#=GS R1A_BCHK4/196-440 AC P0C6T4.1
#=GS A0A1X9JQL5_9ALPC/114-206 AC A0A1X9JQL5.1
#=GS B1PHJ3_9ALPC/111-318 AC B1PHJ3.1
#=GS A0A0U1UZ65_BCHK4/196-440 AC A0A0U1UZ65.1
#=GS R1AB_BC512/111-320 AC P0C6W0.1
#=GS K4KCJ9_9ALPC/111-315 AC K4KCJ9.1
#=GS R1AB_CVPPU/110-310 AC P0C6Y5.1
#=GS G1FEY4_9ALPC/110-310 AC G1FEY4.1
#=GS A3EXF6_BCHK5/196-441 AC A3EXF6.1
#=GS A0A1X9JQL5_9ALPC/194-287 AC A0A1X9JQL5.1
#=GS Q6RD22_SARS/182-423 AC Q6RD22.1
#=GS A0A0U1UZC3_9ALPC/112-317 AC A0A0U1UZC3.1
#=GS D2E219_SARS/182-423 AC D2E219.1
#=GS R9QTH2_SARS/182-423 AC R9QTH2.1
#=GS H9TEX0_9ALPC/110-310 AC H9TEX0.1
#=GS R1AB_MERS1/194-443 AC K9N7C7.1
#=GS G1FEY5_9ALPC/110-310 AC G1FEY5.1
#=GS R1A_MERS1/194-443 AC K9N638.1
#=GS B1PHK0_9ALPC/113-316 AC B1PHK0.1
#=GS R1AB_CVHNL/111-315 AC P0C6X5.1
#=GS A0A172B201_9ALPC/111-312 AC A0A172B201.1
#=GS R1AB_BCHK9/191-395 AC P0C6W5.1
#=GS A0A0U1WHF6_9ALPC/111-315 AC A0A0U1WHF6.1
#=GS A0A1L2KGB4_9ALPC/111-315 AC A0A1L2KGB4.1
#=GS C6GHB5_9ALPC/110-310 AC C6GHB5.1
#=GS R1AB_FIPV/110-310 AC Q98VG9.2
#=GS R1AB_CVH22/112-316 AC P0C6X1.1
#=GS A0A0U1WHG4_9ALPC/111-315 AC A0A0U1WHG4.1
#=GS R1AB_BCHK5/196-441 AC P0C6W4.1
#=GS D9J203_9ALPC/111-312 AC D9J203.1
#=GS B1PHK1_9ALPC/113-316 AC B1PHK1.1
#=GS A0A0U1UZA8_9ALPC/111-318 AC A0A0U1UZA8.1
#=GS A0A023PSX7_SARS/182-423 AC A0A023PSX7.1
#=GS B1PHJ4_9ALPC/111-318 AC B1PHJ4.1
#=GS A0A0U1WHC6_9ALPC/112-316 AC A0A0U1WHC6.1
#=GS A3EXA2_BCHK4/196-440 AC A3EXA2.1
#=GS R1AB_SARS2/182-423 AC P0DTD1.1
#=GS R1AB_SARS2/182-423 DR PDB; 7EXM A; 3-244;
#=GS R1AB_SARS2/182-423 DR PDB; 7EXM C; 3-244;
#=GS R1AB_SARS2/182-423 DR PDB; 7EXM B; 3-244;
#=GS R1AB_SARS2/182-423 DR PDB; 7EXM D; 4-244;
#=GS R1AB_SARS2/182-423 DR PDB; 7MSW A; 4-243;
#=GS R1AB_SARS2/182-423 DR PDB; 7MSX A; 4-243;
#=GS A0A172B3C8_9ALPC/111-312 AC A0A172B3C8.1
#=GS A0A1L2KGB5_9ALPC/111-315 AC A0A1L2KGB5.1
#=GS A0A0U1WHD1_9ALPC/112-316 AC A0A0U1WHD1.1
#=GS A0A0U1WHB2_9ALPC/111-318 AC A0A0U1WHB2.1
#=GS A0A096XNJ3_9ALPC/192-290 AC A0A096XNJ3.2
#=GS A3EXI9_BCHK9/191-395 AC A3EXI9.1
#=GS R1A_BC512/111-320 AC P0C6F6.1
#=GS E0ZN43_BCHK9/191-395 AC E0ZN43.1
#=GS H9TEW9_9ALPC/110-310 AC H9TEW9.1
#=GS Q6RD21_SARS/182-423 AC Q6RD21.1
#=GS A8JNZ0_9ALPC/111-315 AC A8JNZ0.1
#=GS R9QTB2_SARS/182-423 AC R9QTB2.1
#=GS A8JNZ1_9ALPC/111-315 AC A8JNZ1.1
#=GS A0A088DIE1_9BETC/176-416 AC A0A088DIE1.1
#=GS S5YAF0_9ALPC/111-314 AC S5YAF0.1
#=GS R1AB_BCHK4/196-440 AC P0C6W3.1
#=GS A0A1B3Q5W8_9BETC/191-395 AC A0A1B3Q5W8.1
#=GS A0A0U1UZ30_9ALPC/99-303 AC A0A0U1UZ30.1
#=GS A0A0U1WHG1_9ALPC/109-313 AC A0A0U1WHG1.1
#=GS S5Z1D1_9ALPC/111-314 AC S5Z1D1.1
#=GS E3W5I8_9ALPC/110-310 AC E3W5I8.1
#=GS E3W5I9_9ALPC/110-310 AC E3W5I9.1
#=GS R1AB_SARS/182-423 AC P0C6X7.1
#=GS R1AB_SARS/182-423 DR PDB; 7FAC A; 4-132;
#=GS R1AB_SARS/182-423 DR PDB; 7FA1 A; 3-244;
#=GS R1A_BCHK9/191-395 AC P0C6T6.1
#=GS A0A2Z4EVM4_9NIDO/190-394 AC A0A2Z4EVM4.1
#=GS R1A_CVHNL/111-315 AC P0C6U6.1
#=GS R1A_SARS/182-423 AC P0C6U8.1
#=GS U5KNA9_9BETC/201-450 AC U5KNA9.1
#=GS E3W5F6_9ALPC/110-310 AC E3W5F6.1
#=GS D2E220_SARS/182-423 AC D2E220.1
#=GS R1A_CVH22/112-316 AC P0C6U2.1
D9J202_9ALPC/111-312 ....t-VVHVDQFLCGADGKPVRQG---DMKD...YFGDLEE..................IVI.DGITYQHA.......WDVVRDvEVPHAKQTALNVQSIMYL....MDVDHKL..VNGATRQRAAPVKISSKVCLTEPYNSLYKHFGSPYMQNGGNLNECFAKLNFIVANVKCK.CGGESSGVGDWT.GFKSA.CCGTPG..KVIGV...SIGDASVGEA...........................V.ITSKGCGT....GTKF...YAGAVLKYV......GDAEGVSVW........
R1A_SARS2/182-423 ....y-TRYVDNNFCGPDGYPLE-----CIKD...LLARAGKasctlseqldfidtkrgvYCC.REHEHEIA.......WYTERS.EKSYELQTPFEIKLAKKFdtfnGECPNFVfpLNSIIKTIQPRVEKKKLDGFMGRIRSVYPVASPNEC-----------NQMCLSTLMKCDhCGETSWQTGDFV.KATCE.FCGTENltKEGAT...TCGYLPQNAVvkiycpachnsevgpehslaeyhnesgL.KTILRK--....GGRTi.aFGGCVFSYV......GCHNKCAYW........
A0A096XNJ3_9ALPC/114-207 ....n-PIYVDQYLCGPDGTPVKKG--LEFKD...YFMNGGD..................IYVePGKTYVRV.......WDVERK.QDDL---TLDGILSIKYL....SDKPHKL..RDGAIQGVADAVSE---------------------------------------------.------------.-----.------..-----...----------...........................-.--------....----...---------......---------lndtnqmv
R1A_BCHK5/196-441 ....d-FTPIDQYMCGKNGKPIAEFAALMASEgitKLADVEAevksr.......tdsdryIVF.KNKLYRIV.......WNVQRK.DVAYSKQSAFTMNSIVQLd.tmEDVPRHSftIGSEIQVIAPSTAVQANGHLNLKQRLLYAFYGKQAVSE--------PNYIYHSAYVDCTsCGKGSWLTGNAVqGFACD.CGAHYC.aNDVDL..qSSGLVRKNAVllttcpcnkdg....eckhtlpqlvsmM.TDKCDVEV...vGKTFiltYGGVIYAYM......GCSGGTMHF........
E0ZN35_BCHK9/191-395 ....l-VKPVLELLGGIKPDLTLEKLTLALSE...YRNSDG-..................YDL.PGGFVRVA.......VSVIRK.PVPVVKQTIFTVQGVVEQhvegFYYPYS-..TMSVVKHTKPRSDKPLGKTVESIMLSLYGTSG--------------YSPATPVVRLRCSyCDFYGWVPPRDMgTVVCS.CGAEFQ.lTSACVdaeSAGAIKPGCV..........................mL.LDRSPGMRl.ipGNRIyvaFGGAIWSPI......GTVNGVSVW........
A0A023YA54_MERS/196-445 ....d-FIPIDQFMCGKDGAPVPDYATLAASEnliSLADVATdvsar.......adsdgyIDF.KSKLYRIV.......WHVERK.NVPYAKQTIFTINSVVQCdgiqDVPPHTF.tLGGKVDLIVPRNKWTGKTALNLKQKILYTFYGKDALDN--------HSYIYHSAYADCTsCGKGSWLTGNAVqGFACD.CGAQYS.aNDVEL..qSSGVVNPNAIfcatcpfakgdscsssckhtlaqmvsqL.SEKCDVAP...dGKSFtlaFGGVVYAYL......GCLEGTMYF........
R1A_CVPPU/110-310 ....g-AIYVDQYMCGADGKPVIEG---DFKD...YFGDEDI..................IEF.EGEEYHCA.......WTTVRD.EKPLNQQTLFTIQEIQYN....LDIPHKL..PNCATRHVAPPVKKNSKIVLSEDYKKLYDIFGSPFMGNGDCLSKCFDTLHFIAATLRCP.CGSESSGVGDWT.GFKTA.CCGLSG..KVKGV...TLGDIKPGDA...........................V.VTSMSAGK....GVKF...FANCVLQYA......GDVEGVSIW........
U5LR11_9BETC/201-450 .....DVIPVDQYMCGFDGSPIKPYLDLANKE...GLTKLADveadvcs....rvdkqgfLIF.KGTTYRVV.......WFTERK.DVDYSKQTLFTVICVMQRn.gvHDIPAHPftLGSKVEQLKPHVAKGNLVGLTLKAKILYTMYGEDAVEE--------PSYIYHSAFVDCVkCNEGKWCTGNAVaGFACE.CGAAYT.aKQVLL..qSSGLVKSNALfcatcpfaqgdrcsldckhtvpqvvsyL.SEKCVVFP...sGKSFvlaFGGALYTYM......GCAEGTMYF........
C6GHB6_9ALPC/110-310 ....g-AIYVDQYMCGADGKPVIEG---EFKD...YFGDEDV..................IIY.EGEEYHCA.......WLTVRD.EKPLCQQTLLTIREIQYN....LDIPHKL..PNCAIRQVAPPVKKNSKVVLSEEYRKLYDIFGSPFMGNGDSLNKCFDSLHFIAATLKCP.CGAESSGVGDWT.GFKTA.CCGLRG..RVKGV...TLGSVKPGDA...........................V.VTSMSAGK....GVKF...FANSVLQYA......GDVENVSVW........
A0A060A8I5_9ALPC/111-316 ....n-IVPVDQYMCGADGKPVLQESEWEYTD...FFADSEDg................qLNI.AGITYVKA.......WIVERS.DVSYASQNLTSIKSITYC....STYEHTF..PDGTAMKVARTPKIKKTVVLSEPLATIYREIGSPFVDNGSDARSIIKRPVFLHAFVKCK.CGSYHWTVGDWT.SYVST.CCGFKC..KPVLV...ASCSATPGSV...........................V.VTRAGAGT....GVKY...YNNMFLRHV......ADIDGLAFW........
S5PWH2_MERS/194-443 ....d-VTPVDQYMCGVDGKPISTYASLIAKEgitKLADVEAdvasr.......vddegfIML.KNKLYRLV.......WHVERR.DVPYSKQSIFTINSVVQKdsveDTPPHYF.tLGGKIDILTPRNKWSGIAKMPLKQRILYTFYGKESLQD--------PSYIYHSAFTDCGgCGNGSWLTGNAIqGFACG.CGASYT.aNDVEV..qSSGLIKPNALfcatcpfakgdscsssckhsvaqlvsyL.SERCNVIA...dSKSFtlvFGGVAYAYF......GCAEGTMYF........
A0A240FW17_9ALPC/111-292 ....k-VVYVDNYLCGNNGKPVVPKDKWKILS...K-GQQG-..................LLA.DNVYYKVV.......WDVKRD.DVPYEKQNMSSIVSIRYL....IDIPHFL..ADGAVREKKRPPQDYTTMLV----------KGFPFLMA--------YDWKFVNHAVKCGkCDNHVVEAGAFE.SVITS.CCRDEI..VHQGV...VT--AKAGEL...........................V.LTPLSNKK....-LIL...VGSTVLRNI......GTAHNLSIW........
E3W5F5_9ALPC/110-310 ....g-AIYVDQYMCGADGKPVIEG---EFKD...YFGDEDV..................IFY.EGEEYHCA.......WLTVRD.EKPLCQQTLLTIREIQYN....LDIPHKL..PNCAIREVAPPVKKNSKVVLSEEYRRLYDIFGSPFMRNGDSLNKCFDSLHFIAATLKCP.CGAESSGVGDWT.GFKTA.CCGLHG..KVKGV...TLGSVKPGDA...........................V.VTSMSAGK....GVKF...FANSVLQYA......GDVENVSVW........
B0LJQ9_9ALPC/110-310 ....g-AIYVDQYMCGADGKPVIDG---EFRD...YFGDEDV..................IIY.EGEEYHCA.......WLTVRD.EKPLCQQTLLTIREIQYN....LDIPHKL..PNCAIREVAPPVKKNSKVVLSEEYRKLYDIFGSPFMGNGDSLNKCFDSLHFIAATLKCP.CGAESSGVGDWT.GFKTA.CCGLLG..KVKGV...TLGAVKPGDA...........................V.VTSMSAGK....GVKF...FANSVLQYA......GDVENVSVW........
B0LJR0_9ALPC/110-310 ....g-AIYVDQYMCGADGKPVIDG---EFRD...YFGDEDV..................IIY.EGEEYHCA.......WLTVRD.EKPLCQQTLLTIREIQYN....LDIPHKL..PNCAIREVAPPVKKNSKVVLSEEYRKLYDIFGSPFMGNGDSLNKCFDSLHFIAATLKCP.CGAESSGVGDWT.GFKTA.CCGLLG..KVKGV...TLGAVKPGDA...........................V.VTSMSAGK....GVKF...FANSVLQYA......GDVENVSVW........
A0A075Q443_MERS/194-443 ....d-VTPVDQYMCGVDGKPISTYASLIAKEgitKLADVEAdvasr.......vddegfIML.KNKLYRLV.......WHVERR.DVPYSKQSIFTINSVVQKdsveDTPPHYF.tLGGKIDILTPRNKWSGIAKMPLKQRILYTFYGKESLQD--------PSYIYHSAFTDCGgCGNGSWLTGNAIqGFACG.CGASYT.aNDVEV..qSSGLIKPNALfcatcpfakgdscsssckhsvaqlvsyL.SERCNVIA...dSKSFtlvFGGVAYAYF......GCAEGTMYF........
R1A_BCHK4/196-440 .....DCIPIDQYMCGKNGKPIADYAKIVAKEgltTLADIEVdvksr.......mdsdrfIVL.NKKLYRVV.......WNVTRR.NVPYPKQTAFTIVSVVQCd.dkDSVPEHTftIGSQILMV-SPLKATNNKNFNLKQRLLYTFYGKDAVQQ--------PGYIYHSAYVDCNaCGRGTWCTGNAIqGFACD.CGANYS.aNDVDL..qSSGLVPRNALflancpcanng....acshsaaqvyniL.DGKACVEV...gGKSFtltFGGVVYAYM......GCCDGTMYF........
A0A1X9JQL5_9ALPC/114-206 ....n-PIFVDQYLCGADGTPVKR--DVEFKN...YFTDGDT..................YVE.PGKTYKLV.......WNVERK.PGDL---TLSGILSIKYL....SDKPHKL..RDGVVQEVADAVSE---------------------------------------------.------------.-----.------..-----...----------...........................-.--------....----...---------......---------lndtkqlv
B1PHJ3_9ALPC/111-318 ....t-SIPVDNYMCGANGKPVLPEDMWCFCD...YFGDDGD.................nITV.NGQAYHKA.......WNVTRG.DVPYQFQNASTILSIEYL....ADEKHVL..PDGAVAKSAKPPKFSKNIVLSEKYKALYDACGNPFVTNGTNVLEVVTNPIFAHGFVQCK.CGSKHWTTGDWA.GFKSV.CCGIPG..RVLCT...VFGGVAPGSV...........................L.LTSTRVDAs.pgATRY...YHGLTLKHI......CNVDGVACW........
A0A0U1UZ65_BCHK4/196-440 .....DCIPVDQYMCGKNGKPIADYAKIVAKEgltTLADIEVdvksr.......mdldrfIVL.NKKLYRVV.......WNVTRR.NVPYSKQTAFTVVSVVQCd.dkESVPEHT.fTIGSQILMVSPLKATNNKNFNLKQRLLHTFYGKEAVQQ--------PGYIYHSAYVDCNaCGRGTWCTGNAIqGFACD.CGANYS.aNDVDL..qSSGLVPKNALflancpcanng....scshsaaqvysiL.DGKACVEF...gGKSFtltFGGVVYAYM......GCCDGTMYF........
R1AB_BC512/111-320 ....t-TIPVDQFMCGADGAPVIQEGDWTFMD...YFQDSNQ..................FTL.NGITYVKA.......WDVDRK.PNDYAKQNVTCIRRITYI....TDHRHVL..ADGTTMKTARHPKVNKSVVLDSPFDQIYKEVGSPFMGNGSTFVEMLKDPAFFHALITCE.CGRSEWTVGDWK.GYNSL.CCNIKC..KPITI...VTPKAVPGAV...........................V.ITKAGIGA....GLKC...YNNVFLKHIidlvvpGTNLGWGVW........
K4KCJ9_9ALPC/111-315 ....t-TVFVDNFLCGANGLPACSEQEWEFKD...HFGELDE..................VTI.NGTTFVKA.......WNVDRT.PGPYSTQNLLSINSISWC....GEIPHSL..ADGSIRRVAKVVKKSKSVLLGKQFQQLYDSVGSPFVTNGKNLSDVLVKPIYCHALVKCQ.CGKTSWTVGDWS.CYKSM.CCGFNC..KPLAI...VNGEVVPGDV...........................L.VTSDKVSA...sGTKY...YNGMVLKFV......DKIDNACLW........
R1AB_CVPPU/110-310 ....g-AIYVDQYMCGADGKPVIEG---DFKD...YFGDEDI..................IEF.EGEEYHCA.......WTTVRD.EKPLNQQTLFTIQEIQYN....LDIPHKL..PNCATRHVAPPVKKNSKIVLSEDYKKLYDIFGSPFMGNGDCLSKCFDTLHFIAATLRCP.CGSESSGVGDWT.GFKTA.CCGLSG..KVKGV...TLGDIKPGDA...........................V.VTSMSAGK....GVKF...FANCVLQYA......GDVEGVSIW........
G1FEY4_9ALPC/110-310 ....g-AIYVDQYMCGADGKPVIEG---EFKD...YFGDEDV..................IIY.EGEEYHCA.......WITVRD.EKPLCQQTLLTIREIQYN....LDIPHKL..PNCAIREVAPPVKKNSKVVLSEEYRKLYDIFGSPFMGNGDSLNKCFDSLHFIAATLKCP.CGAESSGVGDWT.GFKTA.CCGLHG..KVKGV...TLGAVKPGDA...........................V.VTSMSAGK....GVKF...FANSVLQYA......GDVENVSVW........
A3EXF6_BCHK5/196-441 ....d-FTPIDQYMCGKNGKPIAEFAALMASEgitKLADVEAevksr.......tdsdryIVL.KNKLYRIV.......WNVQRK.DVAYSKQSAFTMNSIVQLd.tmEDVPRHSftIGSEIQVIAPSTAVQANGHLNLKQRLLYAFYGKQAVSE--------PNYIYHSAYVDCTsCGKGSWLTGNAVqGFACD.CGAHYC.aNDVDL..qSSGLVRKNAVllttcpcnkdg....eckhtlpqlvsmM.TDKCDVEV...vGKTFiltYGGVIYAYM......GCSGGTMHF........
A0A1X9JQL5_9ALPC/194-287 davse---------------------------...-------..................---.--------.......------.------------------....-------..-----------------------------------------LNDTKQLVRFIHGFVSCP.CGKSAFTVGGWN.GFATV.CCGVTV.kSPICV..kFSGKAGSIFA...........................L.PLGSRVFG....TKRI...YAGAEFQYC......CDLSGVEIW........
Q6RD22_SARS/182-423 ...vt--RYVDNNFCGPDGYPLD-----CIKD...FLARAGKsmctlseqldyieskrgvYCC.RDHEHEIA.......WFTERS.DKSYEHQTPFEIKSAKKFdtfkGECPKFVfpLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQECNN-----------MHLSTLMKCNhCDEVSWQTCDFL.KATCE.HCGTEN..LVIEGp.tTCGYLPTNAVvkmpcpacqdpeigpehsvadyhnhsnI.ETRLRKGG....RTRC...FGGCVFAYV......GCYNKRAYW........
A0A0U1UZC3_9ALPC/112-317 ...pp--IYVDNYLCGADGTPVVQESMWSYTD...HFGEDCD.................eITL.CGITYVHA.......WNVQRA.DVPYEQQNVTSIFSIEYL....LDVDHAL..QNGAVLNVASGVKYKKSVVLSEGFKKLYDACGVPAVQNGNTLVDILTKPAFFHAIVSCS.CGLSSYTVGDWKiGFRSL.CCGKRL..EPITV...VVGDVKPGDI...........................V.VTSANAGD....GVRY...FNGLTLQYV......GDWEGVSCW........
D2E219_SARS/182-423 ...vt--RYVDNNFCGPDGYPLD-----CIKD...FLARAGKsmctlseqldyieskrgvYCC.RDHEHEIA.......WFTERS.DKSYEHQTPFEIKSAKKFdtfkGECPKFVfpLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQECNN-----------MHLSTLMKCNhCDEVSWQTCDFL.KATCE.HCGTEN..LVIEGp.tTCGYLPTNAVvkmpcpacqdpeigpehsvadyhnhsnI.ETRLRKGG....RTRC...FGGCVFAYV......GCYNKRAYW........
R9QTH2_SARS/182-423 ...vt--RYVDNNFCGPDGYPLE-----CIKD...LLARAGKsmctlseqldfieskrgvYCC.REHEHEIA.......WFTERS.EKSYEHQTPFEIKSAKKFdtfkGECPKFVfpLNSRVKVIQPRVEKKKTEGFMGRIRSVYPVAS-PG----D------CNDMHLSTLMKCNhCDEVSWQTCDFL.KATCEqCGTENS.vREGPT...TCGYLPTNAVlkmpcpacqdpeigpehsvadyhnhsnI.ETRLRKGG....RIKC...FGGCVFAYV......GCYNKRAYW........
H9TEX0_9ALPC/110-310 ....g-AIYVDQYMCGADGKPVIEG---DFKD...YFGDEDV..................IEF.EGEDYHCA.......WTVVRD.EKPLNQQTLFTIQEIQYN....LDIPHKL..PNCATRHVAPPVKKNSKIVLSEDYRKLYDIFGSPFMGNGDCLSKCFDTLHFIAATLRCP.CGSESSGVGDWT.GFKTA.CCGLSG..KVKGV...TLGDVKPGDA...........................V.VTSMSAGK....GVKF...FANCVLQHA......GDVENVSIW........
R1AB_MERS1/194-443 ....d-VTPVDQYMCGVDGKPISAYAFLMAKDgitKLADVEAdvaar.......addegfITL.KNNLYRLV.......WHVERK.DVPYPKQSIFTINSVVQKdgveNTPPHYF.tLGCKILTLTPRNKWSGVSDLSLKQKLLYTFYGKESLEN--------PTYIYHSAFIECGsCGNDSWLTGNAIqGFACG.CGASYT.aNDVEV..qSSGMIKPNALlcatcpfakgdscssnckhsvaqlvsyL.SERCNVIA...dSKSFtliFGGVAYAYF......GCEEGTMYF........
G1FEY5_9ALPC/110-310 ....g-AIYVDQYMCGADGKPVIEG---EFKD...YFGDEDV..................IIY.EGEEYHCA.......WITVRD.EKPLCQQTLLTIREIQYN....LDIPHKL..PNCAIREVAPPVKKNSKVVLSEEYRKLYDIFGSPFMGNGDSLNKCFDSLHFIAATLKCP.CGAESSGVGDWT.GFKTA.CCGLHG..KVKGV...TLGAVKPGDA...........................V.VTSMSAGK....GVKF...FANSVLQYA......GDVENVSVW........
R1A_MERS1/194-443 ....d-VTPVDQYMCGVDGKPISAYAFLMAKDgitKLADVEAdvaar.......addegfITL.KNNLYRLV.......WHVERK.DVPYPKQSIFTINSVVQKdgveNTPPHYF.tLGCKILTLTPRNKWSGVSDLSLKQKLLYTFYGKESLEN--------PTYIYHSAFIECGsCGNDSWLTGNAIqGFACG.CGASYT.aNDVEV..qSSGMIKPNALlcatcpfakgdscssnckhsvaqlvsyL.SERCNVIA...dSKSFtliFGGVAYAYF......GCEEGTMYF........
B1PHK0_9ALPC/113-316 ...sp--VYVDNYMCGANGKPVLPADVWVYQD...YFGEETE..................LIV.NGVKHVKV.......WHVTRT.DIPYQFQSLGAIESIEWL....TDIPHTL..RNGSRLSAARAVKHSKNVVLSEPLKTLYQACGSPFVTNGSTLREAVPKPVFAHAYVACK.CGRKAWSVGDWS.GYKST.CCGVFG..KPQCV...VFGEVVPGDV...........................F.ITTSSVGS....GTRY...YNGLTVKHV......VTVDGLACW........
R1AB_CVHNL/111-315 ....s-VVFVDKYMCGFDGKPVLPKNMWEFRD...YFNNNTD.................sIVI.GGVTYQLA.......WDVIRK.DLSYEQQNVLAIESIHYL....GTTGHTL..KSGCKLTNAKPPKYSSKVVLSGEWNAVYRAFGSPFITNGMSLLDIIVKPVFFNAFVKCN.CGSESWSVGAWD.GYLSS.CCGTPA..KKLCV...VPGNVVPGDV...........................I.ITSTSAGC....GVKY...YAGLVVKHI......TNITGVSLW........
A0A172B201_9ALPC/111-312 ....m-TVYVDQYMCGADGRPVISG---EMRD...YFGDLDD..................IVI.DGIIYSHA.......WDVERDlDVTHDKQTFLNIKSIMYL....QDKDHKL..PNGAIRVRAAPVKLSSKVVLSQPFADMYKHFGSPYMQNGDNLHGCFTKLNFIVANVKCK.CGGESSGVGDWT.GFKSA.CCGLPG..KVIGV...SLGNAAVGEA...........................V.VTSKGCGN....GTKF...YANAVLKHV......GDADDVSIW........
R1AB_BCHK9/191-395 ....l-VEPVMKLLGVIKSDFTLEQLLAALGK...YRTEDG-..................YDL.PDGYVKVA.......IKVGRK.AVPVLKQSIFTVVGVTEQlvpgYYYPFS-..TSSVVEHTKPTRGGPVGKTVEAVMLSLYGTNN--------------YNPATPVARLKCSyCDYYGWTPLKDIgTVNCL.CGAEFQ.lTSSCVdaeSAGVIKPGCV..........................mL.LDKSPGMRl.ipGNRTyvsFGGAIWSPI......GKVNGVTVW........
A0A0U1WHF6_9ALPC/111-315 .....NVVFVDNYMCGADGKPAVPREQWSFEE...HFDDDTE.................dIII.NGVTYRHA.......WNTIRA.DDPYEKQGLLSIKSIEYV....STIPHKL..PNGSVLSVAGPPKKRKAVVLDEKYNKIYNACGVPFVTNGKSISEVVTKPLFLHALVKCK.CGNESWTVGDWT.GFKTT.CCGATG..KVTTF...AVGDVTPGDI...........................V.FTTTGAGT....GTKF...FCGLVLTHV......DTLEGVSAW........
A0A1L2KGB4_9ALPC/111-315 ....d-VVFVDNYMCGFDGKPVLPETIWEFKD...YFGDDVD.................nITI.NGVSYQLA.......WDVTRK.PLSYKQQNVLAIESIRYL....GSKEHTL..RAGCKLFNAKQPKYSAKVVLSDEWIEVYKAFGSPFVTNGSSLLEILTKPVFFNAFVECN.CGNKGWSVGAWD.GYLSP.CCGTPA..KKICV...VPGNVVPGDV...........................L.VTSTNAGT....GTKY...YAGLVVKHV......VNVSGVSLW........
C6GHB5_9ALPC/110-310 ....g-AIYVDQYMCGADGKPVIEG---EFKD...YFGDEDV..................IIY.EGEEYHCA.......WLTVRD.EKPLCQQTLLTIREIQYN....LDIPHKL..PNCAIRQVAPPVKKNSKVVLSEEYRKLYDIFGSPFMGNGDSLNKCFDSLHFIAATLKCP.CGAESSGVGDWT.GFKTA.CCGLRG..RVKGV...TLGSVKPGDA...........................V.VTSMSAGK....GVKF...FANSVLQYA......GDVENVSVW........
R1AB_FIPV/110-310 ....g-AIYVDQYMCGADGKPVIEG---EFKD...YFGDEDV..................IIY.EGEEYHCA.......WLTVRD.EKPLWQQTLLTIREIQYN....LDIPHKL..PNCAIREVAPPVKKNSKVVLSEEYRKLYDIFGSPFMGNGDSLNTCFDSLHFIAATLKCP.CGAESSGVGDWT.GFKTA.CCGLHG..KVKGV...TLGAVKPGDA...........................I.VTSMSAGK....GVKF...FANSVLQYA......GDVENVSVW........
R1AB_CVH22/112-316 .....NVTYTDQYLCGADGKPVMSEDLWQFVD...HFGENEE..................III.NGHTYVCA.......WLTKRK.PLDYKRQNNLAIEEIEYV...hGDALHTL..RNGSVLEMAKEVKTSSKVVLSDALDKLYKVFGSPVMTNGSNILEAFTKPVFISALVQCT.CGTKSWSVGDWT.GFKSS.CCNVIS..NKLCV...VPGNVKPGDA...........................V.ITTQQAGA....GIKY...FCGMTLKFV......ANIEGVSVW........
A0A0U1WHG4_9ALPC/111-315 .....NTVYVDNYMCGSNGVPVLPEDQWEFVD...YFGELTE..................VSI.GDTTYIKA.......WNVDRV.EGPYKSQTLLSINAISYC....GEVIHAL..ADGSTMSYATAVKKNSKTVVNKTYQKLYDNIGVPFVTNGKVLTEIIPKPVFNHGLVKCH.CGKVSWTVGDWS.CYKST.CCGTVC..KPIAI...VNGDVNPGDV...........................V.ITSKQVAT...nGVKY...YNGMVLKYV......DTIEDVHLW........
R1AB_BCHK5/196-441 ....d-FTPIDQYMCGKNGKPIAEFAALMASEgitKLADVEAevksr.......tdsdryIVF.KNKLYRIV.......WNVQRK.DVAYSKQSAFTMNSIVQLd.tmEDVPRHSftIGSEIQVIAPSTAVQANGHLNLKQRLLYAFYGKQAVSE--------PNYIYHSAYVDCTsCGKGSWLTGNAVqGFACD.CGAHYC.aNDVDL..qSSGLVRKNAVllttcpcnkdg....eckhtlpqlvsmM.TDKCDVEV...vGKTFiltYGGVIYAYM......GCSGGTMHF........
D9J203_9ALPC/111-312 ....t-VVHVDQFLCGADGKPVRQG---DMKD...YFGDLEE..................IVI.DGITYQHA.......WDVVRDvEVPHAKQTALNVQSIMYL....MDVDHKL..VNGATRQRAAPVKISSKVCLTEPYNSLYKHFGSPYMQNGGNLNECFAKLNFIVANVKCK.CGGESSGVGDWT.GFKSA.CCGTPG..KVIGV...SIGDASVGEA...........................V.ITSKGCGT....GTKF...YAGAVLKYV......GDAEGVSVW........
B1PHK1_9ALPC/113-316 ...sp--VYVDNYMCGANGKPVLPADVWVYQD...YFGEETE..................LIV.NGVKHVKV.......WHVTRT.DIPYQFQSLGAIESIEWL....TDIPHTL..RNGSRLSAARAVKHSKNVVLSEPLKTLYQACGSPFVTNGSTLREAVPKPVFAHAYVACK.CGRKAWSVGDWS.GYKST.CCGVFG..KPQCV...VFGEVVPGDV...........................F.ITTSSVGS....GTRY...YNGLTVKHV......VTVDGLACW........
A0A0U1UZA8_9ALPC/111-318 ....t-SIPVDNYMCGANGKPVLPEDMWCFCD...YFGDDGD.................nITV.NGQAYHKA.......WNVTRS.DVPYQFQNASTILSIEYL....ADEKHVL..PDGAVAKTAKPPKFSKNIVLSEKYKALYDACGSPFVTNGTNVLEVVTNPIFAHGFVQCK.CGSKHWTTGDWA.GFKSV.CCGIPG..RVLCT...VFGGVAPGSV...........................L.LTSTRVDAs.pgAARY...YHGLTLKHI......CNVDGVACW........
A0A023PSX7_SARS/182-423 ...vt--RYVDNNFCGPDGYPLE-----CIKD...LLARAGKsmctlseqldfieskrgvYCC.REHEHEIA.......WFTERS.EKSYEHQTPFDIKSAKKFdtfkGECPKFVfpLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQEC-----------NDMHLSTLMKCNhCDEVSWQTCDFL.KATCE.QCGTEN..LVCEGp.tTCGYLPTNAVlkmpcpacqdpeigpehsvadyhnhsnI.ETRLRKGG....RTKC...FGGCVFAYV......GCYNKRAYW........
B1PHJ4_9ALPC/111-318 ....t-SIPVDNYMCGANGKPVLPEDMWCFCD...YFGDDGD.................nITV.NGQAYHKA.......WNVTRG.DVPYQFQNASTILSIEYL....ADEKHVL..PDGAVAKSAKPPKFSKNIVLSEKYKALYDACGNPFVTNGTNVLEVVTNPIFAHGFVQCK.CGSKHWTTGDWA.GFKSV.CCGIPG..RVLCT...VFGGVAPGSV...........................L.LTSTRVDAs.pgATRY...YHGLTLKHI......CNVDGVACW........
A0A0U1WHC6_9ALPC/112-316 ..vep--VYVDNYMCGANGKPALPADVWCFQD...YFGDETE..................LVV.NGVRHVKA.......WDVVRT.NLPYQFQSTGAIESITWL....SDVSHVL..RNGSKLSVCKAPKFSKNVKLSEPLNTLYQACGSPFVSNGTDLAGAVGKPVFAHSYVACK.CGNKCWSVGDWS.GYKST.CCGTFG..KVLCT...VFGDVVPGDV...........................L.MTSAAVGS....GTRY...YNGLTIKHV......VTVQNIACW........
A3EXA2_BCHK4/196-440 .....DCIPIDQYMCGKNGKPIADYAKIVAKEgltTLADIEVdvksr.......mdsdrfIVL.NKKLYRVV.......WNVTRR.NVPYPKQTAFTIVSVVQCd.dkDSVPEHTftIGSQILMV-SPLKATNNKNFNLKQRLLYTFYGKDAVQQ--------PGYIYHSAYVDCNaCGRGTWCTGNAIqGFACD.CGANYS.aNDVDL..qSSGLVPRNALflancpcanng....acshsaaqvyniL.DGKACVEV...gGKSFtltFGGVVYAYM......GCCDGTMYF........
R1AB_SARS2/182-423 ....y-TRYVDNNFCGPDGYPLE-----CIKD...LLARAGKasctlseqldfidtkrgvYCC.REHEHEIA.......WYTERS.EKSYELQTPFEIKLAKKFdtfnGECPNFVfpLNSIIKTIQPRVEKKKLDGFMGRIRSVYPVASPNEC-----------NQMCLSTLMKCDhCGETSWQTGDFV.KATCE.FCGTENltKEGAT...TCGYLPQNAVvkiycpachnsevgpehslaeyhnesgL.KTILRK--....GGRTi.aFGGCVFSYV......GCHNKCAYW........
#=GR R1AB_SARS2/182-423 SS ....X-XSEEETTSB-TTSSB-H-----HHHH...HHHHTT-TTS-HHHHHHHHHHTTGGGSS.SSS--EEE.......EEEEE-.SS-GGG--GGGEEEEEE-TT--S-----SS-TTEEEEE------SS--SHHHHHHTTTS--SSGGGS-----------EE--EEEEEE-TTT--EEEEEE-SS.EEE-T.TT--EEE--SS-E...EE-B--TTEEEEEE-HHHHSTTT-TT--HHHHHHHH--.--EEET--....TEEEE.EETTEEEEEE......EEETTEEEE........
A0A172B3C8_9ALPC/111-312 ....m-TVYVDQYMCGADGRPVISG---EMRD...YFGDLDD..................IVI.DGIIYSHA.......WDVERDlDVTHDKQTFLNIKSIMYL....QDKDHKL..PNGAIRVRAAPVKLSSKVVLSQPFADMYKHFGSPYMQNGDNLHGCFTKLNFIVANVKCK.CGGESSGVGDWT.GFKSA.CCGLPG..KVIGV...SLGNAAVGEA...........................V.VTSKGCGN....GTKF...YANAVLKHV......GDADDVSIW........
A0A1L2KGB5_9ALPC/111-315 ....d-VVFVDNYMCGFDGKPVLPETIWEFKD...YFGDDVD.................nITI.NGVSYQLA.......WDVTRK.PLSYKQQNVLAIESIRYL....GSKEHTL..RAGCKLFNAKQPKYSAKVVLSDEWIEVYKAFGSPFVTNGSSLLEILTKPVFFNAFVECN.CGNKGWSVGAWD.GYLSP.CCGTPA..KKICV...VPGNVVPGDV...........................L.VTSTNAGT....GTKY...YAGLVVKHV......VNVSGVSLW........
A0A0U1WHD1_9ALPC/112-316 ..vep--VYVDNYMCGANGKPVLPADVWCFQD...YFGDETE..................LVV.NGVRHVKA.......WDVVRT.NLPYQFQSTGAIESIIWL....SDVPHVL..RNGSKLSVCKAPKFSKNVKLSEPLNTLYQACGSPFVSNGTDLAGAVGKPVFAHSYVACK.CGSKCWSVGDWS.GYKST.CCGTFG..KVLCT...VFGDVVPGDV...........................L.MTSAAVGS....GTRY...YNGLTIKHV......VTVQNIACW........
A0A0U1WHB2_9ALPC/111-318 ....t-SIPVDNYMCGANGKPVLPEDMWCFCD...YFGDEGD.................nITV.NGQAYHKA.......WNVTRS.DVPYQFQNASTILSIEYL....ADEKHVL..PDGAVAKTAKPPKFSKNIVLSEKYKALYDACGSPFVTNGTNVLEVVTNPIFAHGFVQCK.CGSKHWTTGDWA.GFKSV.CCGIPG..RVLCT...VFGGVAPGSV...........................L.LTSTRVDAs.pgAARY...YHGLTLKHI......CNVDGVACW........
A0A096XNJ3_9ALPC/192-290 gvada---------------------------...-------..................---.--------.......------.------------------....-------..-----------------------------------VS---ELNDTNQMVRFIHAFVSCP.CGKSAFTVGSWM.GFATV.CCGKIV.kTPMCV..kFSGEA--GSIfa.......................lpV.GSRGFSAN....GKRS...YAGAEFQFC......CELSGVEIW........
A3EXI9_BCHK9/191-395 ....l-VKPVQDLLGDIRPDFTLEELTLCLSD...YRTDDG-..................YDL.LGGYVKVA.......VKVVRK.PVPVVKQTIFTVQGVIEQcvegYYYPFP-..PMSAVKHTKPRSDKPLGKTVDSIMLSLYGTSG--------------YNPATPVVRLRCShCDFYGWVPLKDMgTVSCS.CSAVHQ.lTSSCIdaeSAGAIKPGCV..........................mL.LDKSPGMRv.ipGNRTyvaFGGAIWSPI......GKVGDVTVW........
R1A_BC512/111-320 ....t-TIPVDQFMCGADGAPVIQEGDWTFMD...YFQDSNQ..................FTL.NGITYVKA.......WDVDRK.PNDYAKQNVTCIRRITYI....TDHRHVL..ADGTTMKTARHPKVNKSVVLDSPFDQIYKEVGSPFMGNGSTFVEMLKDPAFFHALITCE.CGRSEWTVGDWK.GYNSL.CCNIKC..KPITI...VTPKAVPGAV...........................V.ITKAGIGA....GLKC...YNNVFLKHIidlvvpGTNLGWGVW........
E0ZN43_BCHK9/191-395 ....l-VKPVQDLLGDIKPDLTLEKLTLALSD...YRKDDG-..................YDL.PGGFVKIA.......VTVIRK.PVAVVKQTIFTVQGVVEQhvegYYYPYA-..PLGVVKQTKPAAGGPIGKTVEAIMLSLYGTSG--------------YKPATPVARLKCSyCDHFGWTPLKDMgTVVCL.CGAEYQ.lTSSCVdaeSAGLIKPGCV..........................mL.LDKSPGMRv.ipGNRTyvaFGGAIWSPI......GKVNDVTVW........
H9TEW9_9ALPC/110-310 ....g-AIYVDQYMCGADGKPVIEG---DFKD...YFGDEDV..................IEF.EGEDYHCA.......WTVVRD.EKPLNQQTLFTIQEIQYN....LDIPHKL..PNCATRHVAPPVKKNSKIVLSEDYRKLYDIFGSPFMGNGDCLSKCFDTLHFIAATLRCP.CGSESSGVGDWT.GFKTA.CCGLSG..KVKGV...TLGDVKPGDA...........................V.VTSMSAGK....GVKF...FANCVLQHA......GDVENVSIW........
Q6RD21_SARS/182-423 ...vt--RYVDNNFCGPDGYPLD-----CIKD...FLARAGKsmctlseqldyieskrgvYCC.RDHEHEIA.......WFTERS.DKSYEHQTPFEIKSAKKFdtfkGECPKFVfpLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQECNN-----------MHLSTLMKCNhCDEVSWQTCDFL.KATCE.HCGTEN..LVIEGp.tTCGYLPTNAVvkmpcpacqdpeigpehsvadyhnhsnI.ETRLRKGG....RTRC...FGGCVFAYV......GCYNKRAYW........
A8JNZ0_9ALPC/111-315 .....DVVPVDNYMCGADGKPAVPSEQWSFVE...HFDDDTD.................eITV.NGVTFRHA.......WNTVRA.DDPYEKQGLLSIKFIEYI....SNVPHKL..PNGSVLGVAGTPKKRKAVVLDEKYSKLYDACGVPFVTNGKSISEVVTKPLFLHALVECK.CGNESWTVGDWT.GFKTT.CCGVTG..KVITL...AVGDVTPGDI...........................V.FTTPGAGK....GTKF...FCGLVLTFV......DTLEGVSAW........
R9QTB2_SARS/182-423 ...vt--RYVDNNFCGPDGYPLE-----CIKD...LLARAGKsmctlseqldyieskrgvYCC.REHEHEIV.......WFTERS.DKSYEHQTPFEIKSAKKFdtfkGECPKFVfpLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVATPQEC-----------NDMHLSTLMKCNhCDEVSWQTCDFI.KATCE.QCGTE-..NPVCEgptTCGYLPTNAVvkmpcpacqdpevgpehsvadyhnhsnI.ETRLRKGG....RTKC...FGGCVFSYV......GCYNKRAYW........
A8JNZ1_9ALPC/111-315 .....DVVPVDNYMCGADGKPAVPSEQWSFVE...HFDDDTD.................eITV.NGVTFRHA.......WNTVRA.DDPYEKQGLLSIKFIEYI....SNVPHKL..PNGSVLGVAGTPKKRKAVVLDEKYSKLYDACGVPFVTNGKSISEVVTKPLFLHALVECK.CGNESWTVGDWT.GFKTT.CCGVTG..KVITL...AVGDVTPGDI...........................V.FTTPGAGK....GTKF...FCGLVLTFV......DTLEGVSAW........
A0A088DIE1_9BETC/176-416 ..dfh--RYVDNYYCTGDGKPLP-----CIVT...LLEKAGHankpld......damdylRGL.NRMGQPCRdhdhervWEVERD.NAPYPEQSLFSISAIKTL....GEIPHCVfaPDCAVKVMKPRKVKRGADGFMTKLRRVYNINGFDEV-----------KPMALCALHYCEdCGMEMWCHSNFE.EAYCP.CGKIYT..NTPCTl.tSAGYVVEGSVvampcdacksdsd.hsngtfydsckylA.EDKAEPGN....RENFv.yFGGCCFAYV......GCRNGNAIW........
S5YAF0_9ALPC/111-314 .....NTIYVDQYLCGADGKPVVPEEFWDFKD...YFVDDDQ..................VVV.NGTTYIKA.......WVVERA.NVAYEAQNVTAINGITYC....AKIPHTL..PDGSVVRVARKPKIKKSIVLSDVYKPLLEGLGAPFVKNGDTLASILTEPVFLHALVKCT.CGKTMWTVGDWS.CYKSL.CCGVVC..KPLCN...VAGIVNPGSA...........................V.VTRTGLGS....GIKY...YCGMFLRHI......LDVDGVSVW........
R1AB_BCHK4/196-440 .....DCIPIDQYMCGKNGKPIADYAKIVAKEgltTLADIEVdvksr.......mdsdrfIVL.NKKLYRVV.......WNVTRR.NVPYPKQTAFTIVSVVQCd.dkDSVPEHTftIGSQILMV-SPLKATNNKNFNLKQRLLYTFYGKDAVQQ--------PGYIYHSAYVDCNaCGRGTWCTGNAIqGFACD.CGANYS.aNDVDL..qSSGLVPRNALflancpcanng....acshsaaqvyniL.DGKACVEV...gGKSFtltFGGVVYAYM......GCCDGTMYF........
A0A1B3Q5W8_9BETC/191-395 ...la--APIKEVLGGKGAGMSLVELTKFLGK...YRTADG-..................YEL.PSGIVKVA.......VKVVRK.NLPVSKQSIFTVLGVTERvvdgFYYPYS-..TNSVVSYTKPRAGATVGNTVQSVMLSMYGTEA--------------YNPVTPVVRLRCSsCDFYGWVPVKDLgCVTCS.CAAVHQ.iTSSCIdaeSAGLIKQGAV..........................mL.VDRSPSMRv.vpGNRLyvaFGGAIWSPI......GKVNGVQVW........
A0A0U1UZ30_9ALPC/99-303 .....NTVYVDNYMCGSNGVPVLPEDQWEFVD...YFGELTE..................VSI.GDTTYIKA.......WNVDRV.EGPYKSQTLLSINAISYC....GEVIHAL..ADGSTMSYATAVKKNSKTVVNKTFQKLYDNIGVPFVTNGKVLTEIIPKPVFNHGLVKCH.CGKVSWTVGDWS.CYKST.CCGIVC..KPIAI...VNGDVNPGDV...........................V.ITSKQVAT...nGVKY...YNGMVLKYV......DTIEDVHLW........
A0A0U1WHG1_9ALPC/109-313 ...ae--VYVDNYMCDQTGKPVLAADVWTFKD...YFGESDT..................IVI.DGVVYRKA.......WEVVRL.DVPYKAQSVSAISSIEWL....CGVQHVL..PSGTVLDVAKSVSKSKVVLLSDPYADIYDQVGSPFMTNGKNLLEIVVKPCFLHGYVKCN.CGNTHWAVGDWRaGYKSV.CCGLNC..NPICV...AAGYVEPGDV...........................L.FTSKGAGT....GLKY...YKGLTLKFV......GEVENVAVW........
S5Z1D1_9ALPC/111-314 .....NTIYVDQYLCGADGKPVVPEEFWDFKD...YFVDDDQ..................VVV.NGTTYIKA.......WVVERA.NVAYEAQNVTAINGITYC....AKIPHTL..PDGSVVRVARKPKIKKSIVLSDVYKPLLEGLGAPFVKNGDTLASILTEPVFLHALVKCT.CGKTMWTVGDWS.CYKSL.CCGVVC..KPLCN...VAGIVNPGSA...........................V.VTRTGLGS....GIKY...YCGMFLRHI......LDVDGVSVW........
E3W5I8_9ALPC/110-310 ...ga--VYVDQYMCGADGKPVIEG---EFKD...YFGDEDV..................IFY.EGEEYHCA.......WLTVRD.EKPLCQQTLLTIREIQYN....RDIPHKL..PNCAIREVAPPVKKNSKVVLSEEYRRLYDIFGSPFMRNGDSLNKCFDSLHFIAATLKCP.CGAESSGVGDWT.GFKTA.CCGLHG..KVKGV...TLGSVKPGDA...........................V.VTSMSAGK....GVKF...FANSVLQYA......GDVENVSVW........
E3W5I9_9ALPC/110-310 ...ga--VYVDQYMCGADGKPVIEG---EFKD...YFGDEDV..................IFY.EGEEYHCA.......WLTVRD.EKPLCQQTLLTIREIQYN....RDIPHKL..PNCAIREVAPPVKKNSKVVLSEEYRRLYDIFGSPFMRNGDSLNKCFDSLHFIAATLKCP.CGAESSGVGDWT.GFKTA.CCGLHG..KVKGV...TLGSVKPGDA...........................V.VTSMSAGK....GVKF...FANSVLQYA......GDVENVSVW........
R1AB_SARS/182-423 ...vt--RYVDNNFCGPDGYPLD-----CIKD...FLARAGKsmctlseqldyieskrgvYCC.RDHEHEIA.......WFTERS.DKSYEHQTPFEIKSAKKFdtfkGECPKFVfpLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQECNN-----------MHLSTLMKCNhCDEVSWQTCDFL.KATCE.HCGTEN..LVIEGp.tTCGYLPTNAVvkmpcpacqdpeigpehsvadyhnhsnI.ETRLRKGG....RTRC...FGGCVFAYV......GCYNKRAYW........
#=GR R1AB_SARS/182-423 SS ...-----EEETTSB-TTSSB-H-----HHHH...HHHHTT-TTS-HHHHHHHHHHTTGGGTT.SSS--EEE.......EEEEE-.SS-GGG--GGGEEEEEE-TT--S-----SS-SSEEEEE------SS---HHHHHHHCCSS-SSGGGSEE-------------EEEEEE-TTT--EEEEEE-SS.EEE-T.TT--EE..E--SS-.EE--B--TTEEEEEE-HHHHSTTT-TT--HHHHHHHC--.--EEETTE....EEEE...ETTEEEEEE......EEETTEEEE........
R1A_BCHK9/191-395 ....l-VEPVMKLLGVIKSDFTLEQLLAALGK...YRTEDG-..................YDL.PDGYVKVA.......IKVGRK.AVPVLKQSIFTVVGVTEQlvpgYYYPFS-..TSSVVEHTKPTRGGPVGKTVEAVMLSLYGTNN--------------YNPATPVARLKCSyCDYYGWTPLKDIgTVNCL.CGAEFQ.lTSSCVdaeSAGVIKPGCV..........................mL.LDKSPGMRl.ipGNRTyvsFGGAIWSPI......GKVNGVTVW........
A0A2Z4EVM4_9NIDO/190-394 ....l-VKPIMDLLGPLKSGYTLANLLDDLAP...YKCDDG-..................YEL.PTGTVCVA.......FEVVRK.NVPAAKQNIFTVQGVLNQlvpgIYYPYS-..SGSKVVTTKPARDSPAAKTVSSIMLSLYGTAQ--------------YAPVTPVARIACPtCGFLGWLPLKDAgTVVCG.CNATYN.mTSTAVqaeSSGFIRQGAV...........................LcLEKGEAMRlipgGRTYl.aFGGAIWSPI......GKDKDVTVW........
R1A_CVHNL/111-315 ....s-VVFVDKYMCGFDGKPVLPKNMWEFRD...YFNNNTD.................sIVI.GGVTYQLA.......WDVIRK.DLSYEQQNVLAIESIHYL....GTTGHTL..KSGCKLTNAKPPKYSSKVVLSGEWNAVYRAFGSPFITNGMSLLDIIVKPVFFNAFVKCN.CGSESWSVGAWD.GYLSS.CCGTPA..KKLCV...VPGNVVPGDV...........................I.ITSTSAGC....GVKY...YAGLVVKHI......TNITGVSLW........
R1A_SARS/182-423 ...vt--RYVDNNFCGPDGYPLD-----CIKD...FLARAGKsmctlseqldyieskrgvYCC.RDHEHEIA.......WFTERS.DKSYEHQTPFEIKSAKKFdtfkGECPKFVfpLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQECNN-----------MHLSTLMKCNhCDEVSWQTCDFL.KATCE.HCGTEN..LVIEGp.tTCGYLPTNAVvkmpcpacqdpeigpehsvadyhnhsnI.ETRLRKGG....RTRC...FGGCVFAYV......GCYNKRAYW........
U5KNA9_9BETC/201-450 .....DVIPVDQYMCGFDGSPIKPYLDLANKE...GLTKLADveadvcs....rvdkqgfLIF.KGTTYRVV.......WFTERK.DVDYSKQTLFTVICVMQRn.gvHDIPAHPftLGSKVEQLKPHVAKGNLVGLTLKAKILYTMYGEDAVEE--------PSYIYHSAFVDCVkCNEGKWCTGNAVaGFACE.CGAAYT.aKQVLL..qSSGLVKSNALfcatcpfaqgdrcsldckhtvpqvvsyL.SEKCVVFP...sGKSFvlaFGGALYTYM......GCAEGTMYF........
E3W5F6_9ALPC/110-310 ....g-AIYVDQYMCGADGKPVIEG---EFKD...YFGDEDV..................IFY.EGEEYHCA.......WLTVRD.EKPLCQQTLLTIREIQYN....LDIPHKL..PNCAIREVAPPVKKNSKVVLSEEYRRLYDIFGSPFMRNGDSLNKCFDSLHFIAATLKCP.CGAESSGVGDWT.GFKTA.CCGLHG..KVKGV...TLGSVKPGDA...........................V.VTSMSAGK....GVKF...FANSVLQYA......GDVENVSVW........
D2E220_SARS/182-423 ...vt--RYVDNNFCGPDGYPLD-----CIKD...FLARAGKsmctlseqldyieskrgvYCC.RDHEHEIA.......WFTERS.DKSYEHQTPFEIKSAKKFdtfkGECPKFVfpLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQECNN-----------MHLSTLMKCNhCDEVSWQTCDFL.KATCE.HCGTEN..LVIEGp.tTCGYLPTNAVvkmpcpacqdpeigpehsvadyhnhsnI.ETRLRKGG....RTRC...FGGCVFAYV......GCYNKRAYW........
R1A_CVH22/112-316 .....NVTYTDQYLCGADGKPVMSEDLWQFVD...HFGENEE..................III.NGHTYVCA.......WLTKRK.PLDYKRQNNLAIEEIEYV...hGDALHTL..RNGSVLEMAKEVKTSSKVVLSDALDKLYKVFGSPVMTNGSNILEAFTKPVFISALVQCT.CGTKSWSVGDWT.GFKSS.CCNVIS..NKLCV...VPGNVKPGDA...........................V.ITTQQAGA....GIKY...FCGMTLKFV......ANIEGVSVW........
#=GC SS_cons ...----SEEETTSB-TTSSB-H-----HHHH...HHHHTT-TTS-HHHHHHHHHHTTGGGTT.SSS--EEE.......EEEEE-.SS-GGG--GGGEEEEEE-TT--S-----SS-TTEEEEE------SS--SHHHHHHCCCSS-SSGGGSEE---------EE--EEEEEE-TTT--EEEEEE-SS.EEE-T.TT--EEE.ESSSC-.EEE-B--TTEEEEEE-HHHHSTTT-TT--HHHHHHHC--.--EEETTE....CEEEE.EETTEEEEEE......EEETTEEEE........
#=GC seq_cons ....s.slaVDpYMCGsDGKPlh.t...phcD...ahuDtst..................lsh.pGppYchA.......WpVtRc.-hsYppQolhsIpuIphh....t-hPHpl...susltplssssKtspphsLstchcpLYshhGsshhpN........sp.hahsAhlcCs.CGppoWssGDas.Gapss.CCGhhs..pshsl...osG.ltPGsl...........................l.hTptssus....Gs+a...FuGslhpal......GsscsluhW........
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