#=GF ID ComR_TPR
#=GF AC PF18710.7
#=GF DE ComR tetratricopeptide
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE ECOD:EUF08223
#=GF GA 26.50 26.50;
#=GF TC 26.50 26.50;
#=GF NC 26.40 25.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 81514348 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Repeat
#=GF CL CL0020
#=GF RN [1]
#=GF RM 27907189
#=GF RT Structural Insights into Streptococcal Competence Regulation by
#=GF RT the Cell-to-Cell Communication System ComRS.
#=GF RA Talagas A, Fontaine L, Ledesma-Garcia L, Mignolet J, Li de la
#=GF RA Sierra-Gallay I, Lazar N, Aumont-Nicaise M, Federle MJ, Prehna
#=GF RA G, Hols P, Nessler S;
#=GF RL PLoS Pathog. 2016;12:e1005980.
#=GF RN [2]
#=GF RM 27907154
#=GF RT Pheromone Recognition and Selectivity by ComR Proteins among
#=GF RT Streptococcus Species.
#=GF RA Shanker E, Morrison DA, Talagas A, Nessler S, Federle MJ, Prehna
#=GF RA G;
#=GF RL PLoS Pathog. 2016;12:e1005979.
#=GF DR INTERPRO; IPR040799;
#=GF DR SO; 0001068; polypeptide_repeat;
#=GF CC In Gram-positive bacteria, cell-to-cell communication mainly
#=GF CC relies on extracellular signaling peptides. ComR is a member of
#=GF CC the RNPP family, which positively controls competence for
#=GF CC natural DNA transformation in streptococci. It is directly
#=GF CC activated by the binding of its associated pheromone XIP [1].
#=GF CC The crystal structure analysis of ComR shows that it contains an
#=GF CC N-terminal helix-turn-helix (HTH), DNA binding domain (DBD) and
#=GF CC a C-terminal tetratricopeptide repeat (TPR) domain. The TPR
#=GF CC domain is composed of 11 alpha-helices forming 5 TPR motifs
#=GF CC followed by an additional C-terminal alpha-helix 16 called CAP.
#=GF CC The pheromone XIP binding site is found in the TPR region.
#=GF CC Biochemical and mutational analysis indicate that, if the
#=GF CC interacting XIP is accepted it can then trigger the
#=GF CC conformational change of the TPR domain to open the DBD-TPR
#=GF CC interface to allow dimer formation that is required to bind DNA
#=GF CC [2].
#=GF SQ 64
#=GS A0A4R0QFG6_9STRE/1-207 AC A0A4R0QFG6.1
#=GS A0A380JC45_STRDO/73-292 AC A0A380JC45.1
#=GS A0A172Q9D4_9STRE/76-290 AC A0A172Q9D4.1
#=GS A0A380JC26_STRDO/75-294 AC A0A380JC26.1
#=GS A0A1L8QQ60_9ENTE/1-211 AC A0A1L8QQ60.1
#=GS A8AZW8_STRGC/82-296 AC A8AZW8.1
#=GS A0A242K672_9ENTE/1-112 AC A0A242K672.1
#=GS A0A3P1VDL4_9STRE/75-293 AC A0A3P1VDL4.1
#=GS A0A2X3W5P8_9STRE/73-296 AC A0A2X3W5P8.1
#=GS A0A0H2ZQ34_STRP2/71-140 AC A0A0H2ZQ34.1
#=GS A0A380K3S0_9STRE/1-164 AC A0A380K3S0.1
#=GS A0A139NGW5_9STRE/72-296 AC A0A139NGW5.1
#=GS A0A2X3VIM9_9STRE/75-293 AC A0A2X3VIM9.1
#=GS A0A3L9DNT9_9STRE/73-296 AC A0A3L9DNT9.1
#=GS A0A172Q9J0_9STRE/77-295 AC A0A172Q9J0.1
#=GS G5KFI4_9STRE/1-49 AC G5KFI4.1
#=GS Q8DWI6_STRMU/73-296 AC Q8DWI6.1
#=GS B9DST9_STRU0/72-295 AC B9DST9.1
#=GS A0A8D0F567_STROC/14-110 AC A0A8D0F567.1
#=GS A8AZ57_STRGC/75-293 AC A8AZ57.1
#=GS A0A0H2ZNR1_STRP2/70-291 AC A0A0H2ZNR1.1
#=GS A0A1T4MJM7_9ENTE/73-293 AC A0A1T4MJM7.1
#=GS A0A380K385_9STRE/73-294 AC A0A380K385.1
#=GS G5K5D9_9STRE/73-296 AC G5K5D9.1
#=GS Q8DVT6_STRMU/75-294 AC Q8DVT6.1
#=GS A0A380K563_9STRE/74-293 AC A0A380K563.1
#=GS A0A139NAG1_9STRE/71-295 AC A0A139NAG1.1
#=GS Q9A1Y2_STRP1/73-296 AC Q9A1Y2.1
#=GS A0A242K5G9_9ENTE/1-125 AC A0A242K5G9.1
#=GS A0A172Q9H5_9STRE/75-281 AC A0A172Q9H5.1
#=GS A0A172QA32_9STRE/72-295 AC A0A172QA32.1
#=GS A0A242K4G7_9ENTE/75-293 AC A0A242K4G7.1
#=GS Q8E2E0_STRA5/73-296 AC Q8E2E0.1
#=GS A0A139NN13_9STRE/1-218 AC A0A139NN13.1
#=GS A0A0E4CTV3_9STRE/73-296 AC A0A0E4CTV3.1
#=GS A0A242K4G0_9ENTE/75-293 AC A0A242K4G0.1
#=GS A0A6M0L5D2_9LACT/75-295 AC A0A6M0L5D2.1
#=GS A0A0H2URY1_STRPN/70-291 AC A0A0H2URY1.1
#=GS F5X439_STRPX/73-294 AC F5X439.1
#=GS A0A380K4I3_9STRE/72-294 AC A0A380K4I3.1
#=GS K1LYB9_9LACT/75-296 AC K1LYB9.1
#=GS A0A139NGV0_9STRE/15-234 AC A0A139NGV0.1
#=GS A0A139NHK9_9STRE/15-234 AC A0A139NHK9.1
#=GS A0A2L0D265_9STRE/72-295 AC A0A2L0D265.1
#=GS A0A1G6BIT0_9STRE/73-296 AC A0A1G6BIT0.1
#=GS A0A940PCS7_9ENTE/75-293 AC A0A940PCS7.1
#=GS G5KFI5_9STRE/73-240 AC G5KFI5.1
#=GS A0A5C5TCY1_9STRE/75-293 AC A0A5C5TCY1.1
#=GS A0A139NF75_9STRE/74-297 AC A0A139NF75.1
#=GS Q5M612_STRT2/75-294 AC Q5M612.1
#=GS A0A380K4J4_9STRE/76-120 AC A0A380K4J4.1
#=GS A0A242K4M9_9ENTE/75-165 AC A0A242K4M9.1
#=GS A0A3P1V774_9STRE/74-297 AC A0A3P1V774.1
#=GS A0A0H2URW8_STRPN/71-141 AC A0A0H2URW8.1
#=GS A0A0H3MSK4_STRS4/75-296 AC A0A0H3MSK4.1
#=GS A0A917JHK8_9ENTE/73-294 AC A0A917JHK8.1
#=GS A8AZ18_STRGC/75-293 AC A8AZ18.1
#=GS A0A940PDD4_9ENTE/75-293 AC A0A940PDD4.1
#=GS A0A1Q8E8B2_STRAI/73-296 AC A0A1Q8E8B2.1
#=GS A0A2L0D697_9STRE/78-290 AC A0A2L0D697.1
#=GS Q8CY78_STRR6/97-165 AC Q8CY78.1
#=GS A0A917A8I5_9STRE/73-141 AC A0A917A8I5.1
#=GS A0A934UE40_9STRE/72-295 AC A0A934UE40.1
#=GS Q8DND0_STRR6/70-291 AC Q8DND0.1
A0A4R0QFG6_9STRE/1-207 ........................................-------------.----MDQDRIKEREEHFDEIFSEYYDELPEEEQLAIDALQSSFEVYHTGQVDFGVDLIPEYFEQLKKKKRYRMNDLILIDLYLTa...aAISYFDSSIFQKSDFLHFCR...NLLQQRKYLLSEELFFLNRLILT.AVA.MRIYLKDADLVLELLNESNAIMEVTEDFQKKSIYCLLQCEYAIFYKKDKELAKHYYEEALLFAKLFNDKKLQEQLQVEW................................
A0A380JC45_STRDO/73-292 ........................................PDEYFELKNRVVK.FPTYGDKARIDQKMKMIEEIYDNYFEVLPEDELLFLDLTESLLGGIHEKVLPNIEEIYDDAFEQVLKKKVFHYNDYLYIDYFLF.....--KCQKEKYYDKNILKKIER...KILKQSLTFEELYNIELLMSVMN.LIG.VYVSHDDYQDTMPLIEKGYRIIDKAQLHTYKPGLLEVEARYHIRVEGNKEKSKEIYQQALMLGEILGDQVIINDIKKEM................................
A0A172Q9D4_9STRE/76-290 ........................................PKRYLELKNRLIK.SHTYGDKERIAKQEEIFDEIYNNYYDFLPEEEQLLVEALQVQLNVFTSRDIGFALGFLEEYFQQILTKKNYSYNDLLIVYVYFT.....---CCAMGLEDKEYFDELSK...KVLLHVDYSDLEKLYLVERVLLS.ILV.QVD----PTEYLIYTKIFREIMKESNHFQHKPVVYVFEAKYYLDIEQNKNKTIESYDKAIMFAKMLNDEVLARNIEIEK................................
A0A380JC26_STRDO/75-294 ........................................PDTYFELKHRLVK.FPTYGDPERVGQKQAMIEEAYEKYFTVLPEEELLFLDLSEKILNWSQTKKLVAIEEIYEDAFEQLQEKKIYNLNDLMVLGYYLI.....--GIQQQKYYDKKLFNKLKN...RLLEQEPSTDELYNIDLLSILIS.VLG.VYVQHGDYGATLPVFKKVYQLIEETQQPSYRPSVMMVEAKYYLNVEGDKEQAGQLYDQAINFATLLGDQVLADGLREEK................................
A0A1L8QQ60_9ENTE/1-211 ........................................-----------MK.QTMYKDSIRAEKVNLLFDQIYDNFYDQINEEEQLTIDILRATTDIVVFNNVQFESGLLKEYFPQTLLKKELCELDFLLIYLYFF.....YIFGKDKAYKNRNTTKQAIN...KLVKNSDYSNDSNAYLAIKIHII.ALN.FLSELKDYDTYKQLLDISKTISEENQEFQKKPILQMMEAKYLLFHVSDTEKAKVMYRVAAKTAMLLGDNIAHDQIL---lem.............................
A8AZW8_STRGC/82-296 ........................................PKRYLELKNKLIR.SHTYGDEERISILEEMFDEIYENFYEHLPEEEQLLVEVLQVQLDVFSSRDITYGLSLLEEYFQQILKKKKYSYNDLLIINLYFL.....---CCATGLEDKTYFEELSK...KVLLYIDYSDNDRIYILERILIG.ILI.QVK----TEDYLIYTKVLREITESTNNFQHKPAIYAFEAKYYLKVEESYEKAEQSYNKAIEFANLLNDQVLASNLLKEK................................
A0A242K672_9ENTE/1-112 .....................................mfl-------------.------------------------------------------------------------------------------------.....----------------TLFS...RVTDQIDYSIDIEQFLLIKALIV.SIS.VFLEFGNYDKIIDAVTAANKIMNVNQDFQKKPIIDMHEGKYYLFSQKDVPTAKQKFEEGAKLAELQGDSVISQKILKEW................................
A0A3P1VDL4_9STRE/75-293 ........................................PQRYLDLRYKMQR.LPHYGNPERIMEREAILDEIYESFFDNLPEEEQLAVQIEHALLDIAATRRPEFDQGLVDEYLERSLAKSQLDMNDMNILFLRQL.....---ILAFNGFDKEEFVNLLS...RIIHQRTNTTVEGLRLIQNVVIS.SIG.MLCHFEEYDMLYQLHQVLEELMELIKDYSDKAFVYMTRWKINLYLEHNLEAAKENYSSARQLAQLLSEELLFTNIRNEW................................
A0A2X3W5P8_9STRE/73-296 ........................................PRRYKEIKYLLLH.TPTYGNQAKLEERESLFDDIFNNYYDHLPEDEQLIMDALQSKLDIHFSDNINFGRGILNDYFDQVLLKDYYQLNDLIIIDLYLSc...lTINGLEDSIFRQSAFDRIIE...VLICQGDSLPLDDLFMLNNVLLN.NFE.LFFLLKKHKEIEEIILLSNNIMQKIHDFHKKPVVNILEWKYYLLVKNDVKKAEESYHSAVMLAQLIGNAYLAEKLEEEW................................
A0A0H2ZQ34_STRP2/71-140 .......................................d-KEYLELKYFLMR.TPTYEDETIAQKKESVFDKIFEEYYDRLPEEERFII------------------------------------------------.....--------------------...-----------------------.---.-------------------------------------------------------------------------------pnysylalanytvqklpeklv...........
A0A380K3S0_9STRE/1-164 ........................................-------------.--------------------------------------MQAQLDVFTSRDYQYGLTLLEEYFQQILKKSHYSYNDLLIINLYFF.....---CCALGLEDKSHMEQLAS...RVIEDIDYSDLDRVYATERILVT.LL-.---INAEPEDYLTYTSVLRDIIERTNNFQHKPAVYAFEAKYYLLVKKDKAKAKALYDKAILFANMLNDEALAEEFIRE-s...............................
A0A139NGW5_9STRE/72-296 ........................................PQEYLSLKYDILN.TQVYRHPDLMTQVLKQISDVHERFYADLPQEEAYIFGLLEKMLRAYNLEEDQMPITEIKEHLRPLLNHLYFDLNTLIMIRYVLNre.isYDEKYKKSLFGASYIAMVQE...ELVNLTTTVRREDWFICRDNLIT.ALT.LSLNHADHEKCFLLLKVLKENMARFQDVQKKMIVMMLEWKIFL-LNNQLDEAQETYDKTKAFVQIIGDKHVLMKIMEEW................................
A0A2X3VIM9_9STRE/75-293 ........................................PDEYFTMKYQLFK.FPTYGDKERLAQKAQMIEDIYEKYFDCLPEEELYTLELSDNTLDYISTGKTAAAEDIFEDFFKQLFLKKKYTFNDLLLVSYYAV.....---QCQNKGYEEEVLKSLEA...TVLKQDVSGDEYYNIELLGTLTA.IAG.VYLDHAEYSQLKILADRMHDIIAETQQHSAKPIALIYDAKYYLYAENNVEKAKECYDLATLLAQNFGDNILEANLRDE-r...............................
A0A3L9DNT9_9STRE/73-296 ........................................PKRYKELKYLILR.TPTYLDEERLKVREEQFDEIFEEYYDKLPEAEQVLVDIVQARFEVFNSGNKEFGSSILEDYFEQVKKKKFYGINDMALIDLYLIc...vLVENFDVEFYDEVTYNQFIQ...NLRNQGSYLNVEDLFFLNKIYLI.ICS.VLVKKGDYAQLEDYLDELYHLILKSQDFQRMPLYYMYRWKYSLSYLDDKNSAEEFYAHAILFAEMTSDLYLVKKLKDEW................................
A0A172Q9J0_9STRE/77-295 ........................................PDSYFRMKYRLFK.IPSYSDPQRLDEKIELIETIYDHYFSLLPEEELFTLDLLDNIFDYLRKGQRPAAEDSFAEAFKELLLKPRYSLNDLLLAKFYLI.....---QHHSGAYNKALVQKMET...RALKQEISGDDYYNLELINFFSD.LSA.LYTSHAEYPKLDVPVKRMHDLIRETRQDSMIPLTLMFEAKYYIYVKQCRNKAEELYNAAVWLAESFDDVLLKTKLIHE-r...............................
G5KFI4_9STRE/1-49 ........................................-------------.------------------------------------------------------------------------------------.....--------------------...-----------------------.---.------------------------------MPIICIMEWKYFLNCLLDFKKAKSCHTKAILFANMMGDDYLEEKINEEW................................
Q8DWI6_STRMU/73-296 ........................................PSRYKELKYLLLR.TPTYGDQQRLAEKETYFDEIFSQFYDDLPEEEQLIIDGLQSKLDIHFSDNIDFGVGILNDYFDQILRKTNYQVNDLILIDLYFSc...lTVSGLDSAIFDSRKYNQLLE...TLLKQVDCLPLEDLFVLNNVLLN.NFG.LLLELKKYDFVKQLIAVSNKIMDRTHDFQKKPIVNLLTWKHHLFVEKDYAEAKKSYDAAILFAQLTENINLRENLEKEW................................
B9DST9_STRU0/72-295 ........................................PKRYQELKYLILR.HPTYMNTDSIEERESQFDIIFEDYYADLPEEEQVLIDRLRSRFEVYQSGNSVYGQDLLLEYIDQIKKKKTYDLNDIFFIDLYLTc...gYVSSFKETLFDKGIFECFTS...KLILLEEKLDFKDLFLLNNVLMT.AIA.VGLTLEEYVKIRTLLNVCRRIMTITQDFQRMPIYYMYEWRYTLFHEKDFRKAPYYYQQSLLFARTHGDEYLKTMIVNAW................................
A0A8D0F567_STROC/14-110 .............................segffsvlvqt-------------.------------------------------------------------------------------------------------.....--------------------...------------------VVLMNdLAT.VLDAQGHYDEAYSYVKRAAELAKETQHPEEHMVLNNLAA--ILMHKEDFLQAKQVYKEALEQAQQKGDVASVQHIQEE-l...............................
A8AZ57_STRGC/75-293 ........................................PSGYLELKYRLEK.LYHYGDGERLQQREELIEEIYRKYFDQLPEEEQLYLQIKQAKNDMVLTENIAYDQGLIDEYLDQALAKEKLTEMDLEIIDLRLL.....---ALGLKDFDKKEFTCLLN...KLLVAVADYPTNGLEKIQTRIIF.AAG.VLSHYQEYDRLPEILRVLEELMLRRNDFQDRVFSYALQWKIALFLENNLEKAEDNYQKVKLMLELLPEDVLKENMRLDW................................
A0A0H2ZNR1_STRP2/70-291 ........................................PSAYLELKYQILR.EPIYGKEEEYDKKEACLEEIYKTYFDNLPKEEQLACEVLQACLDTSRTRRPEYAELILEEHMPQIIEKEAYSINDMLLIRLFFY.....QMLIRKDLAKFINQIEKLML...FLLEQKKVTQIENYFIIRDTLIS.GMC.CLEKVGVTDCFNDYLSCLQEIMDKTQDYQKKPLVFMFLWKQALRVERDFSLAESFYQSSKTFAKLIGDGFLVKELTEEW................................
A0A1T4MJM7_9ENTE/73-293 ........................................PKRYLELKNLLFRgIKVYQNEERAETVDEQFDEIYNNYFEDLPRYEQDTIELKQILHDMTLTKTAGSAEEIIAESFDRVYKKDDLDLNDFLIIKLYFN.....--LSILKNEVDTEEVKTLSQ...KVIEKIESAIDLELLVIGSILTS.IAI.ILIEKKNYEELLKIIEIGEKLRKKTLDFRSKPVFCMLKGKCILFHQKDPELAKQHYQEAITSAEMLEDSFLSEKIKEE-l...............................
A0A380K385_9STRE/73-294 .......................................a--DYLELKQKLLR.IPTYGDQARLKEREQYFTSIYERFYDQLPEDEQLIIDCLQSKLDVHFSDNDSFGLGILQDYFEQTFKKSTYTVNDFVFFDLYLVc...fAYKKNQEHFYEEEQYDLVMA...KLLNSNPPLAEE-KFQLNNVLLN.NIK.LAFGLEKWDIIENIVSKSNQLMTEIHDFQKRPILSLIEWKYQLYAKQDTALATQSYQNAILFAKLIGDDYLEKQLSQEW................................
G5K5D9_9STRE/73-296 ........................................PKRFKELKYLILR.TPTYMDGDKLKTREAQFDEIFEDYYDQLPEVEQLVIDCLQSKFDVYQSGDINFGSPLIQEYINQISKNTKYQLNDLLIIDLYLTc...aVVSNFSKYHFDLSLYQEFVN...TILKSEEELLLEDLFMLNNILHT.CLD.VSIRLKDYLKVEQMLLLSQKIMSRIQDFQKIPMYCMYYWKYALYHLNDFAKAKHFYEQSVMFTSLTNDNYLVKKLEKEW................................
Q8DVT6_STRMU/75-294 ........................................PDDYWELKGQIVK.FPTYADKERLQQKQELIEEIYDKYFDILPEDELLFLDLSENILDSFHEKDIPNIEEIYDDAFEQVLKKETFAFNDYLYMSYFLQ.....--KCGKTADYDQTTFKLLEQ...KLLKQELTVDELYNIELLIAVME.ASG.VYALHNDYQNLLPLMKKAQRIIDKAQLHTYKPPLLELEAKYYVKVVKDKKKAKELYQQALVMGEVLGDPVIIADVKMEM................................
A0A380K563_9STRE/74-293 .......................................s-KDYLKLKVEFIR.LSTYDDSDRKAKKEEIIDTIFEKYYDNLPSDEQLTLTILSTEMEMLHSKDTTYGEELFKEVQSKIFNIQRITVNEILWMNFYLV.....-YISGREDLYSKEKINDILA...IIISI-DNDDELFLELEIKLCVT.LCG.VMIWSNTLEKFSKLRPTFKRLILKHSDSKSIPIYHMMNGKYAMLVEGKRREALLHYDRALEEARFLEDDILYQRISEEM................................
A0A139NAG1_9STRE/71-295 ........................................PKRYQELKYFLLH.HPDYGDKELQEQKEEYFDEIFECFYDKLPRDEQVMIDCLQAIDQVRATDNEQYGQGIIEDYIETLKNQSSFSANDFLKLRLYFLc...mGAEYFKQGTLSKKEQADIKRlfeMVCNQVEQVETSELFLVRDTLFA.SLG.CCETMGALELFEIAIEKLKWITEKTRDFQKTPIIFMVEWKYYI--QTDFNLAYQRYQEAIMFAKLFGNEQLIQSLDGEW................................
Q9A1Y2_STRP1/73-296 ........................................PKRYKELKYLILR.TPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQNDLILLELYLAy...lDIEGMDGQYSDKIFYDSLLD...NLSEQFEQFELDELFIVNKIIID.ISS.LSLKNNRLDNLEKAIEMSQKIMAKIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEW................................
A0A242K5G9_9ENTE/1-125 ........................................-------------.----------------------------------------------------------------------------MIIELYFH.....---CIHFKDYDEQLFMTLSD...KVIEQVDYSVDVELFLLIKVLLV.AIS.VFIEYDNYDRLIGAVKVANLIMQTNQDFQKKPAVDVFEGKYWLFSQGDVNRAEQKYL----------------------dgaqsvsythldvykrq...............
A0A172Q9H5_9STRE/75-281 ........................................PQAYFEQKYKLIK.FPSYGDAERLAPKK------------QLPEEELFTLDLLEKSFDRMTVGESGSAEQIYEDFFKQLLSKETYSLNDILLVKYYFI.....---QCQDSVFDRKTFQHLVA...RLLKQEITGDEYYNVELLGALSA.LAG.VYVVSADYSDMKPTLDKMDDVVNQTMQHVYKPILLMLEAKYYLYQGHNFQKAKSCYDLALTLAENFGDTVLINNLKKER................................
A0A172QA32_9STRE/72-295 ........................................PARYEELKYLIMR.TPIYADTNRVELVETYFDEVYEQYYDNLPEEEQLAIDILQSSLDVQITDNIEFGSILLQDYFEQVKAKRIYSINDLLIVGLYFYq...iSSESIYSDDISSETLDMLAG...RLILQTHYIVPSYLFLLRDVLLQ.CGG.MLLLTHSYQHLPAIVQELNTIINKTQDYQKKPLVDMLEWKYYLYVKQNFSRAQQKYQQAVQFSAMIDDAVLKENLEKEW................................
A0A242K4G7_9ENTE/75-293 ........................................PQRYQQLKYKLYR.LVTYNEEDRLLKRKRYFNEIYEHYYADLPEEEQLAIDGQQATMEVHLKEETDFGEGILHDYFSQITNKTEYTNNDLLIIELYFH.....---CIHFKNYDDTLFMTLLD...HVIDQIAHSIDTTLLLLHKLLLL.AAS.VFMEYDNYDRLKSVVNASNDIMKKSQDFQKKPVINLLEGKYWLFAQKDKIKAQQKYEDGAQCAQLFGDFVLSDKIMAEW................................
Q8E2E0_STRA5/73-296 ........................................PKRYKELKYLILR.IPTYADAERLKLRECQFDHIFEEFYDNLPEDECLAIDSLQAKFEVYQTGDINFGVEVLCECFDKVKYKEKYTLNDLIIIDLFLTc...aVVSKFNNRAFTKEVFQTICK...TLISQNHKLTAEDLFWFNHVLLN.CVF.VGLCLNSEECLAEMLEVSRQTMVSTHDFHKMPLYFMYQWKYFITIDNDIKSAENAYQQSIMFSKMIDDKHLIKKLELEW................................
A0A139NN13_9STRE/1-218 ........................................----------MLR.RPTYGNEELLEKKDQVFREIYDDYYDNLPVEEQMAIDAYSSGLDILRTEDAVYGNEIIHRHFYEIYEKEFYTINDLIVIRLFIIwldtsHQQQTNDVSKNMVYLENLAE...KLPKQRDNYDLEEVFVLRDLLIN.LIIqMGRFQLKLEKLPELFDVVEDIMEESHDLQKKPVLLQLKWTYYLKVKDNYEEAYRCYQDALQLTQLLGDAHLKALLESV-w...............................
A0A0E4CTV3_9STRE/73-296 ........................................PEDYLNLKYDILR.TPTYGENKKIDWRDQILTEIYDNYYDDLPEEEQLAVDTIQSFFDVHDTSEAIYGKEILEEYFFQISHKDAYSINELLMIRLFLEh...aRMTELSKFPKENAVFQHLLK...TLPCQVNVVRPKDLFILRDVLFV.MVG.VAGSKEQNDCIPAFIQTIEQIMNRTQDYQKLPILKMISWKYKLYVDKNKKDAEQLYEAAKLSAGMIGDPNLLEKIENEW................................
A0A242K4G0_9ENTE/75-293 ........................................PKGYLQLKRRLYK.FYTYKEQERKAKKNQLFKEIYETYYDDLPEEEQLSIDVQSATNVLAMTDNVEFGEGILGDYFSQVMQRQEFSVNDLLIIELYLF.....---YIHLREYDEVVFLSLFN...KLVKQIDCSLDVDQFLLIRVLIV.SIS.VFIEYGNYDKIIDAVTAADRVMKSNQDFQKKPILDMYEGKYYLFSQKDSTSAKQKFEEGAKLAELQGDSVISQKILKEW................................
A0A6M0L5D2_9LACT/75-295 ........................................PEEYYDLKKRIIQ.LHTLQHKEKTQEKEYLFKQIYTHFFDSLTTEEQLSIDILQKEMQIVTTKDFSVGKAILEEHFDHVKRKRTYSFNDLLIIDIFFL....sILAEVNDFHIYKYYINKFKQ...NLLNHECYYHSEYY-IIQKCFFA.LLG.IITQYDDFSDFYLCLNKLKEILTYTHDIEKKPIINMLEAKYFI-YKKDFKLAKNFYTSAIKGAQYLNDTPLEEKILLE-m...............................
A0A0H2URY1_STRPN/70-291 ........................................PSAYLELKYQILR.EPIYGKEEEYDKKEACLEEIYKTYFDNLPKEEQLACEVLQACLDTSRTRRPEYAELILEEHMPQIIEKEAYSINDMLLIRLFFY.....QMLIRKDLAKFINQIEKLML...FLLEQKKVTQIENYFIIRDTLIS.GMC.CLEKVGVTDCFNDYLSCLQEIMDKTQDYQKKPLVFMFLWKQALREERDFSLAESFYQSSKTFAQLIGDEFLVKKLTEEW................................
F5X439_STRPX/73-294 .......................................t--RYKELKYLLLR.TPTYGDEERLKRQTSYFDEISEKYYEVIPEEERLIIDCLQSKLDVHFSDDVNFGEGILNDYFDQVIRKKNFQINDLVLIDLYFAc...lASAKSFVGIYSLDLYDKLME...CLLDQENLSP-ETSLILNNVLLN.NVD.LVLRFHRESFMKRIIIKSDTIMTSVHDFQRRPVLSLVEWKYYLQFKKDFLAAQKSYSNAILFANLIGDTYLENKLIEEW................................
A0A380K4I3_9STRE/72-294 ........................................PKRYNELKYLILR.IPTYSDKERLKEREQQFEEIFEDYYDNLPEEEQLIIDGLQSKFEVYQSGNIHFGTDMIAEYFHQVKKKKSYTLNDLAIIDLYLLi...aAISQFDEQHFQKEDFKIICD...TLLIQGEELAVEDRFLLNNLLLN.CVN.IALNLKLAANIQPMLELSHKTMVLIQDFQKMPIYNMYRWKYAL-LQDNQTEAEDYYNQSVMFSKMLNDEHLIQQLDDEW................................
K1LYB9_9LACT/75-296 ........................................PFEYYQIKDRLMN.FASYGLKDKIQEKDDLYEIVFQKYYDYLPEEEQIAIDIMHATSDVVNEHIDLYGQAIIDDYFDQVKLKSSYTLNDLLIIRLYLS.....QVDFTNEQYFDDNLIDTMLS...KVLNQVDFIHYNMVNFGISFYID.SIT.TLFHYKNFNRIEEILTCLDTLIHIDKKAEDLIICTMLKAKWYLYAKNSIPMTKYFYQQAIDYANLFNEVFLADKLTDE-l...............................
A0A139NGV0_9STRE/15-234 ........................................PDSYYEKKNRLIK.FPTYGDSGRIAQKLQLIAEVHEEYDELLPEDELLTLDILESVMNFSLLEKGPKTEEIFEDVFLQAQKKKTFLLNDLLVIHYYFL.....--EIHRNKYIDEKLLGQLER...KLLVQEISSEEVYDILLITTLMD.IAT.IHMLKDDYKPILQFVNRVLQIADEAQLHTYKPIATTMKAKYFNHYEHNMEKAEQYYDEAMAFAKLLGDDVLAQGIKQEK................................
A0A139NHK9_9STRE/15-234 ........................................PDSYYEKKNRLIK.FPTYGDSGRIAQKLQLIAEVHEEYDELLPEDELLTLDIFESVMNFSLLEKGPKTEEIFEDVFLQAQKKKKLSTNDLLVIHYYFL.....--ENHDKKYLDKKILEMLCR...KLLNQEISADETHNITLIVVLMS.CAA.VYLMLEEFKTILPIANRLLQFVDEAQLQTYKPGALALKAKYYSRYLGDSERANRYYDKALSFARLLNDDALVRGIKQEK................................
A0A2L0D265_9STRE/72-295 ........................................PFRYKELKYLIMR.TPTYRQEQQIKQITQYFDEIYLDFFEKLPEDEKIAIEVLQTSMDIHLDEDVNFGGDLVRESFQQIQLKKRYELNDLLIIRLYFFy...iYFANFQDTLFDLSIVKKLCG...YLKKQAQFTHPSDLFLLRDILLQ.AIT.ILIKLEEFQDASDLIEQTRDIISTTQDYQKQPILDMMEWKLILAQHNNRGAAEAKYNEALLFSRIVGNQYLEEQLIIEW................................
A0A1G6BIT0_9STRE/73-296 ........................................PKRYTELKYLILR.TPTYMDAERLRIREEQFDEIYEKFYEELPEDEQLTITFIQSKFEVYQTGDTEFGTDVIEDYFKQVQKKKLYTLNDIVLIDLFLTc...sIVSNFTSHLFDNAIYELLSS...NLIKQSEYLPIEDLPLLNSVLLV.CAD.ASVRLEKFNLLSNLLSASHSLMTKIQDFQKMPIYNMLMWEYYLFGENNYVQAENHYNQSILFAKMMNDIHLAEKLEKEW................................
A0A940PCS7_9ENTE/75-293 ........................................PHRYIEIKNSIIK.TSIYGERDRIQSLEASFDELFSDYYDNLPEDEQLFVDLQQAKMDIHFNADDLFWRSIIEDYIAQLFVKKLYNENDLILIEVYLH.....--YRFDKEYLPEKIY-PLIE...TAIEQINFYLDSDALLLLRILIC.AMS.LFETHKDYTLFEICLRTANFIMTKHQDYKKKPIVLMLEGKFILFSKKDSEAGIKMYQSGSTFARMIDDEFLAKKIEEE-l...............................
G5KFI5_9STRE/73-240 ........................................PKRYKELKYLILR.TPVFTDVSKINLREQQLDEIYEIYYDELPEIEKLAIDCIQATLDTSLTKDVNFGIGILNDYLIQTKKKKKYQINDLILINLYLAc...lDITKKKGNLYDSHFYKTIFE...IIQQNVQNYHIEEKFIVQQILIQ.YFL.LSLYYEEFDYLCDIVKLTKQIL---------------------------------------------------------d...............................
A0A5C5TCY1_9STRE/75-293 ........................................PESYFEKKYLLFK.SSSYGNTERIAEKHRIIEEIYQEYFDLLPDEELLTLDLIERLLDWRLHSEGERADSLFADYFEQVLIKDVYVLNDLLLLQYYAV.....---QCQDVTYESEKFGICFE...KVRKQAIQGNEFYNVALLGVLSA.FAG.SYLVSQDYEKMLQTVERMDEIIQQTLQQVYRPVTLCFRAKYAVYQSRDKQKAQQAYDMAILLAKDIGDDILWTNLTKEK................................
A0A139NF75_9STRE/74-297 ........................................PEDYLKLKYQLIR.TTSYGDKDVLSELDEAVDAIFARYFDDLPEEEQFIIEVLQSKLYTYEMEGERFGKPILEENLSKLRDKKQYTINDLLIVDLYQTh...lDDEDLLSKSFDIDCFNAIVR...TTLDSIEGLGREYLFKARDVLLY.VPY.AEFIRKDFRYSKEVLECLNTIMTMTQDYQQKPLVKMMEWQYLLGYKQDVDGAKECYQEAVSLAKLFGNEFLAEKLTEEW................................
Q5M612_STRT2/75-294 ........................................PDEYYEMKNRLIK.FPTYRNPDRIKSKLTLIEEVYEKFFDILPEEELLTLDILENILSFTSWEESPKVEEIYEDLFEQVKRKRKFSTNDLLVIDYYFF.....--HLYGRKQYDKKLFERIIK...RVLNQEIWTDDVYNIVLFNDLMA.IAA.LKIFHNSFSDFLTVVDKALAVIEKSQLYSYKPSVFVLKAKYELLHKENKKEAAENYDKAIMFASVLEDSVLEESIKA--gk..............................
A0A380K4J4_9STRE/76-120 ........................................PKRYLELKNRLTK.THTYGDPKRIKELEGFLDEIYEHYYDSLPEEE----------------------------------------------------.....--------------------...-----------------------.---.-------------------------------------------------------------------------------................................
A0A242K4M9_9ENTE/75-165 ........................................PKRYLQLKQRLYK.LYTYKEEERIAKKEQTFDEIYENYYDQLPEEEQLSIDVQQASMDVHLAENADFGDGILHDYLYQILQKKEYSINDLLI------.....--------------------...-----------------------.---.-------------------------------------------------------------------------------................................
A0A3P1V774_9STRE/74-297 ........................................PRRYKELKYQILR.APTYLDEVRLQEREAQFDEIFTDYYDQLPEEECLMVDCIQATMDVALSQNIDFGIGIIQDYFEQVKRKKHLLENDLILLELYFIc...lIISNFDAKIYNSQNFDNLVE...NLLEQEKYGDIDNLFLVNKALIK.AFG.ASVRLKKYKKLEEIAVTCRRIMTTTGDFQKMPILNLIEWKYYLYSLNDLPSAEACFENAIKFSQIISDDYLEENLNSEW................................
A0A0H2URW8_STRPN/71-141 .......................................d-KEYLELKYFLMR.TPTYEDETIAQKKESVFDKIFEEYYDRLPEEERFII------------------------------------------------.....--------------------...-----------------------.---.-------------------------------------------------------------------------------pnysylaltnytvqklpeklve..........
A0A0H3MSK4_STRS4/75-296 ........................................PERYSKLKFDVLR.TPTYGNEDLAEKRDAMMTEIYDDYYDELPEEEKIAIDAIQSRIDTLESGTAGFGKEILEDYFEQIFRKRKYELNDLLIVRLHLE.....YVRLSSCDSEIFRQFLKIIE...HLHEQINIINSNDLFVLRDTLLS.CVN.ILGSKKYYEPIPKIFDSVDKIIQSTQDFQKKPIVSVLKWKYALFVDKDRDEAEKHYLDAVLFAKLIENRELEQKIEEDW................................
A0A917JHK8_9ENTE/73-294 ........................................PKEYLLLKNKIMK.QTMYKDPTRIERVNLLFDQMYDKFYDRISEEEQLTIDILRATTDILVFNNIQFESGLLKEYFPQMLLKKELRELDFLLIYLYLL.....YTYGKSTSYKLTSTTNEVLQ...KIINNSNNSNDSNAYLAIRVHIF.ALH.FLSKLKDYETYKQLLDISKTISEENQEFQKKPILQMMEGKYLLFHMGDIKKAKEMYRIAAKTARLLGDNIAHDHI----llem............................
A8AZ18_STRGC/75-293 ........................................PPEYIDLKYQLQT.LYHYGDPERLRLLEKIIDEIYENYFENLPEEEQLSIQIAQATVDMVSAKDPSFDQGLLDEYLEQAMKKKELSFNDVEIIQLRLL.....---SLALGDFNQEEFVDLLG...KVILAADYFPLSDLEKVQNTIVS.AAG.VLAHYGIYDILPDIVNVLNDIMTKRRDFQDNIFVHALNWKVALFVEDNLEKAKNDYQKVCMMADLLSEDLVKRNMQEEW................................
A0A940PDD4_9ENTE/75-293 ........................................PKKYLELKYSICK.IPTYDEAEQIKRKERSFDEIYEVYYPNLPEEEQLAIDVLQTSLDVHMSQNITFGQGIIDDYLLQIKLKEEYSINDLLIIELYFG.....---CIYYQGYEKEIFNKILY...RVIEQANFIIDTDLFYIRKVLFA.AAS.ITLVQNEYHELKKVIQVLKLIMKHTQDFQQKPILSMIEGKYYLFAENNSELAKEKYDDALVCAGIFENDLLVRRIEAEW................................
A0A1Q8E8B2_STRAI/73-296 ........................................PDQYVKLKYDILR.TPTYDQLDLIEKRNEKLLEIYEHFYDMLPDIERLAIDTIQSTIDVLETQSDVFGKEIIKTHIPQIEWKPKYDVNDLLIIHLFIEh...aYLSTMAKSSASRKVFLRLVL...GLPEQVVMMEPEDLFVLRNVIFA.AIR.VLGSKGIYDPIPALFQGLDQIMQITQDFQKYPIFSMLRWKYELLVHRDVQRAYIYCKEAMIFAQLMGNRHLMGRLHDQW................................
A0A2L0D697_9STRE/78-290 ........................................PQSYVSLKRRIVQ.FKSYEDPERLNYLDGLMDEL-QTYYDSVPEEEQMAIEVLQADLDVFVTHKTAFAEQLIEEYFEQVLLKKAYNWNDYLLISLYLF.....---LCAVGIEDSRYFDYFIP...SIFSKGDLSDPDIAYQMEEVVLA.VLA.QE----NVAYYPDCIDTLDRVIKVTKHYQNKPILEMFKAKLAL-FQGDIEQMESSYQTAFLIAESLDEPILLNRLKME-y...............................
Q8CY78_STRR6/97-165 .......................................d-KEYLELKYFLMR.TPTYEDETIAQKKESVFDKIFEEYYDRLPEEERFII------------------------------------------------.....--------------------...-----------------------.---.-------------------------------------------------------------------------------pnysylalanytvqklpekl............
A0A917A8I5_9STRE/73-141 ........................................PQDYLNLKYRVLR.MAGFGDEKYLQLKDSYLEKIYECY------------------------------------------------------------.....--------------------...-----------------------.---.-------------------------------------------------------------------------------lvtpfdsmreelfnshiwsrflyvyigkydyl
A0A934UE40_9STRE/72-295 ........................................PERYQTLKYLLLR.TQTYSETKRLLNREAYLDEIYIDYYEQLPEEEQLVIDCLQSKLDVHMSENINFGITILNDYFEQLLLKKQYTINDLILIELYFIc...iSTDRFSKRLYHEESYHLLMA...NIFSQINHLPVENLYVLNNVLLN.NFG.VALKLGHQNHIEAILETSYEIMMTIQDFQKMPILKMLQWKYYLDYYNDHSKAEKAYQEALSFSDLINDKHLKEKIKKEW................................
Q8DND0_STRR6/70-291 ........................................PSAYLELKYQILR.EPIYGKEEEYDKKEACLEEIYKTYFDNLPKEEQLACEVLQACLDTSRTRRPEYAELILEEHMPQIIEKEAYSINDMLLIRLFFY.....QMLIRKDLAKFINQIEKLML...FLLEQKKVTQIENYFIIRDTLIS.GMC.CLEKVGVTDCFNDYLSCLQEIMDKTQDYQKKPLVFMFLWKQALRVERDFSLAESFYQSSKTFAKLIGDGFLVKELTEEW................................
#=GC seq_cons ........................................PccYh-LKhhlh+.hsoYs-pc+lpp+-phh-EIa-pYaDpLPEEEpLhl-hlpuph-hh.spphtauptllp-ahpQlhtKcpashNDlllIcLYhh........thppthhspphhpplhp...pllpQ.p.ht.pthhhl.phLls.hhs.hhhthtpapph.thlphhpplhppsp-apc+Pll.hhchKYhLhhppshppAcphYppAhhhAphhsDphLhpplppEh................................
//
